Patent application title: DIAGNOSTIC KIT FOR SOLID CANCER AND MEDICAMENT FOR SOLID CANCER THERAPY
Inventors:
Hideki Shimada (Ichikawa-Shi, JP)
Takeshi Tomonaga (Chiba-Shi, JP)
Takaki Hiwasa (Chiba-Shi, JP)
Kazuyuki Matsushita (Chiba-Shi, JP)
Takenori Ochiai (Chiba-Shi, JP)
Fumio Nomura (Chiba-Shi, JP)
Masaki Takiguchi (Funabashi-Shi, JP)
Assignees:
MEDICAL & BIOLOGICAL LABORATORIES CO., LTD.
HIDEAKI SHIMADA
IPC8 Class: AC12Q168FI
USPC Class:
435 6
Class name: Chemistry: molecular biology and microbiology measuring or testing process involving enzymes or micro-organisms; composition or test strip therefore; processes of forming such composition or test strip involving nucleic acid
Publication date: 2010-12-30
Patent application number: 20100330554
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Patent application title: DIAGNOSTIC KIT FOR SOLID CANCER AND MEDICAMENT FOR SOLID CANCER THERAPY
Inventors:
HIDEKI SHIMADA
TAKESHI TOMONAGA
TAKAKI HIWASA
KAZUYUKI MATSUSHITA
TAKENORI OCHIAI
FUMIO NOMURA
MASAKI TAKIGUCHI
Agents:
BIRCH STEWART KOLASCH & BIRCH
Assignees:
Origin: FALLS CHURCH, VA US
IPC8 Class: AC12Q168FI
USPC Class:
Publication date: 12/30/2010
Patent application number: 20100330554
Abstract:
The present invention provides novel solid cancer antigenic proteins, and
diagnostic kits for solid cancer and therapeutic agents for solid cancer
based on the antigenic proteins. Specifically, the present invention
provides a human solid cancer antigenic polypeptide having an amino acid
sequence selected from the group consisting of SEQ ID NOS: 2, 4, 6, 8,
10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44,
48, 50, 52, 54, 56, 59, 61, 63, 65, 67, 69, 71, 73, and 75.Claims:
1. A polynucleotide having a nucleotide sequence selected from the group
consisting of SEQ ID NOS: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25,
27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 46, 47, 49, 51, 53, 55, 57, 58,
60, 62, 64, 66, 68, 70, 72, and 74.
2. A method for diagnosing primary esophageal cancer comprising detecting the expression of at least one human esophageal cancer antigenic polypeptide in a sample, characterized in that the human esophageal cancer antigenic polypeptide has an amino acid sequence selected from the group consisting of SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 48, 50, 52, 54, 56, 59, 61, 63, 65, 67, 69, 71, 73, and 75.
3. A method for diagnosing primary esophageal cancer comprising detecting the expression of at least one human esophageal cancer antigenic polypeptide in a sample, characterized in that the human esophageal cancer antigenic polypeptide is encoded by a polynucleotide having a nucleotide sequence selected from the group consisting of SEQ ID NOS: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 46, 47, 49, 51, 53, 55, 57, 58, 60, 62, 64, 66, 68, 70, 72, and 74.
4. The method for diagnosing primary esophageal cancer according to claim 2, wherein the detection of expression of the human esophageal cancer antigenic polypeptide is determined by detecting an antibody against the esophageal cancer antigenic polypeptide in the sample using the esophageal cancer antigenic polypeptide.
5. The method for diagnosing primary esophageal cancer according to claim 2, wherein the detection of expression of the human esophageal cancer antigenic polypeptide is determined by detecting the esophageal cancer antigenic polypeptide in the sample using an antibody against the esophageal cancer antigenic polypeptide.
6. The diagnostic kit for solid cancer according to claim 2, wherein the means of detecting the expression of the human solid cancer antigenic polypeptide is a primer or probe comprising a polynucleotide consisting of the entire or a partial sequence of a polynucleotide encoding the solid cancer antigenic polypeptide or a complementary sequence thereof.
7. The method for diagnosing primary esophageal cancer according to claim 4, wherein the esophageal cancer antigenic polypeptide or the antibody is immobilized on a solid phase.
8. The method for diagnosing primary esophageal cancer according to claim 4, wherein the esophageal cancer antigenic polypeptide or the antibody is labeled.
9. The method for diagnosing primary esophageal cancer according to claim 2, wherein the sample is selected from the group consisting of serum and blood.
10. A medicament for preventing or treating solid cancer comprising a gene encoding a prophylactic or therapeutic agent for solid cancer and a means of targeting to human solid cancer.
11. The medicament according to claim 10, wherein the means of targeting to human solid cancer is an antibody against a solid cancer antigenic polypeptide.
12. The medicament according to claim 10, wherein the means of targeting to human solid cancer is a nucleotide sequence of an expression control region of a polynucleotide encoding a solid cancer antigenic polypeptide.
13. The method for diagnosing primary esophageal cancer according to claim 5, wherein the esophageal cancer antigenic polypeptide or the antibody is immobilized on a solid phase.
14. The method for diagnosing primary esophageal cancer according to claim 5, wherein the esophageal cancer antigenic polypeptide or the antibody is labeled.
Description:
PRIORITY INFORMATION
[0001]This application is a Divisional of co-pending application Ser. No. 10/594,771 filed on Sep. 29, 2006, and for which priority is claimed under 35 U.S.C. §120; application Ser. No. 10/594,771 is the National Stage Application of PCT International Application No. PCT/JP2005/006222 filed on Mar. 24, 2005, which claims the benefit of priority of Application No. 2004-095732 filed in Japan on Mar. 29, 2004 under 35 U.S.C. §119; the entire contents of all are hereby incorporated by reference.
TECHNICAL FIELD
[0002]The present invention relates to diagnostic kits for solid cancer and medicaments for preventing or treating solid cancer.
BACKGROUND ART
[0003]All solid cancers are characterized by the presence of malignant tumors. Examples thereof include esophageal cancer, gastric cancer, lung cancer, kidney cancer, thyroid cancer, parotid gland cancer, head and neck cancer, soft tissue and bone sarcoma, urinary tract cancer, bladder cancer, uterine cancer, liver cancer, breast cancer, ovarian cancer, and fallopian tube cancer. Thus, in particular, treatment of progressive solid cancer is difficult, resulting in death in many cases. Therefore, early tumor detection is the most important objective of therapeutic measures against solid cancer.
[0004]Hitherto, tumor markers such as CEA and CA19-9 have been reported and used for diagnosis of the solid cancers listed above and for the prognosis thereof. However, with any tumor marker, the percentage of positive results is as low as 20% to 30%. In particular, during the early stage of cancer, negative results are obtained when using most such markers. In addition, since poor therapeutic outcomes are obtained in the case of the progressive solid cancers listed above, early detection of cancer is the most effective. Thus, novel and effective tumor markers have been expected to be discovered.
[0005]In addition, molecular biological diagnostic methods using antigenic protein markers are disclosed in JP Patent Publication No. 7-51065 A (1995), WO00/060073, and JP Patent Publication No. 2000-511536 A, for example. In addition, a SEREX method (serological identification of antigens by recombinant expression cloning) whereby proteins produced using mRNA of tumor cells obtained from a cancer patient are subjected to screening with the patient's autoserum has been reported (Proc. Natl. Acad. Sci. USA 92: 11810-11813, 1995 and U.S. Pat. No. 5,698,396). Further, it has been reported that the aforementioned SEREX method was used to isolate cancer antigens recognized by IgG antibodies in the cases of malignant melanoma, kidney cancer, esophageal cancer, colorectal cancer, and lung cancer, for example (Int. J. Cancer 72: 965-971, 1997; Cancer Res. 58: 1034-1041, 1998; Int. J. Cancer 29: 652-658, 1998; Int. J. Oncol. 14: 703-708, 1999; Cancer Res. 56: 4766-4772, 1996; Hum. Mol. Genet 6: 33-39, 1997). Further, JP Patent Publication No. 2001-333782 A discloses malignant melanoma antigenic proteins identified by the SEREX method, DNA sequences encoding the proteins, and a method for diagnosing malignant melanoma using such proteins and DNA sequences. However, in order to improve diagnostic accuracy with regard to solid cancer, it is essential to prepare as many protein markers having high antigenicity as possible so as to use them in combination.
[0006]Meanwhile, as therapeutic methods for solid cancer, surgical extraction of cancer tissue, systemic administration of anticancer drugs, and the like have been carried out. However, as described above, in the case of progressive solid cancer, such therapeutic methods have had few effects. Even when solid cancer is found during the early stage, these therapeutic methods impose heavy physical burdens on patients, which has been problematic.
DISCLOSURE OF THE INVENTION
[0007]As described above, it has been pointed out that the molecular biological diagnostic method using cancer tissue-specific antigenic protein markers is effective as a method for early diagnosis of solid cancer. Thus, several new antigenic protein markers have been suggested. However, in order to improve diagnostic accuracy with regard to solid cancer, it is essential to prepare as many protein markers having high antigenicity as possible so as to use them in combination.
[0008]In addition, since such antigenic protein markers are dominantly expressed in solid cancer tissue, the markers are expected to be applied to therapeutic methods of selectively targeting cancer tissue.
[0009]Thus, it is an objective of the present invention to provide novel solid cancer antigenic proteins, diagnostic kits for solid cancer, and therapeutic agents for solid cancer based on the antigenic proteins.
[0010]As a result of intensive studies to attain above objectives, the present inventors have found novel antigenic polypeptides that are specific to human solid cancer, and have found that solid cancer can be diagnosed and that solid cancer can be prevented or treated with the use of the expression of such antigenic polypeptides. Thus, this has led to the completion of the present invention.
[0011]That is, the present invention relates to a human solid cancer antigenic polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 48, 50, 52, 54, 56, 59, 61, 63, 65, 67, 69, 71, 73, and 75.
[0012]The present invention also relates to a polynucleotide encoding the human solid cancer antigenic polypeptide.
[0013]Also, the present invention relates to a polynucleotide having a nucleotide sequence selected from the group consisting of SEQ ID NOS: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 46, 47, 49, 51, 53, 55, 57, 58, 60, 62, 64, 66, 68, 70, 72, and 74.
[0014]The present invention further relates to a diagnostic kit for solid cancer comprising a means of detecting the expression of at least one human solid cancer antigenic polypeptide in a sample derived from a subject, characterized in that the human solid cancer antigenic polypeptide has an amino acid sequence selected from the group consisting of SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 48, 50, 52, 54, 56, 59, 61, 63, 65, 67, 69, 71, 73, and 75.
[0015]The present invention also relates to a diagnostic kit for solid cancer comprising a means of detecting the expression of at least one human solid cancer antigenic polypeptide in a sample derived from a subject, characterized in that the human solid cancer antigenic polypeptide is encoded by a polynucleotide having a nucleotide sequence selected from the group consisting of SEQ ID NOS: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 46, 47, 49, 51, 53, 55, 57, 58, 60, 62, 64, 66, 68, 70, 72, and 74.
[0016]Examples of the means of detecting the expression of the human solid cancer antigenic polypeptide(s) include the solid cancer antigenic polypeptide or a partial peptide thereof, an antibody against the solid cancer antigenic polypeptide, and a primer or probe comprising polynucleotide consisting of the entire or a partial sequence of a polynucleotide encoding the solid cancer antigenic polypeptide or a complementary sequence thereof.
[0017]In addition, the means of detecting the expression of the human solid cancer antigenic polypeptide(s) may be immobilized on a solid phase and/or labeled.
[0018]Examples of the solid cancer include colorectal cancer, esophageal cancer, gastric cancer, and breast cancer.
[0019]Examples of the sample include serum, blood, hemocytes, and tissue.
[0020]The present invention also relates to a medicament for preventing or treating solid cancer comprising a means of inhibiting the functions or expression of at least one human solid cancer antigenic polypeptide, characterized in that the human solid cancer antigenic polypeptide has an amino acid sequence selected from the group consisting of SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 48, 50, 52, 54, 56, 59, 61, 63, 65, 67, 69, 71, 73, and 75.
[0021]The present invention further relates to a medicament for preventing or treating solid cancer comprising a means of inhibiting the functions or expression of at least one human solid cancer antigenic polypeptide, characterized in that the human solid cancer antigenic polypeptide is encoded by a polynucleotide having a nucleotide sequence selected from the group consisting of SEQ ID NOS: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 46, 47, 49, 51, 53, 55, 57, 58, 60, 62, 64, 66, 68, 70, 72, and 74.
[0022]Examples of the means of inhibiting the functions or expression of the human solid cancer antigenic polypeptide(s) include an antibody against the solid cancer antigenic polypeptide, a means capable of inhibiting transcription of a gene encoding the solid cancer antigenic polypeptide, and a means capable of inhibiting translation of a gene encoding the solid cancer antigenic polypeptide.
[0023]Further, the present invention relates to a medicament for preventing or treating solid cancer comprising a gene encoding a prophylactic or therapeutic agent for solid cancer and a means of targeting to human solid cancer.
[0024]Examples of the means of targeting to human solid cancer include an antibody against a solid cancer antigenic polypeptide and a nucleotide sequence of an expression control region of a polynucleotide encoding a solid cancer antigenic polypeptide.
BRIEF DESCRIPTION OF THE DRAWINGS
[0025]FIG. 1A shows results of a comparison in terms of the specific expression of an antigenic protein between cancer tissue and normal tissue of a colorectal cancer patient.
[0026]FIG. 1B shows results of a comparison in terms of the specific expression of an antigenic protein between cancer tissue and normal tissue of a colorectal cancer patient.
[0027]FIG. 2 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 41 and an antibody in the serum of a patient.
[0028]FIG. 3 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 43 and an antibody in the serum of a patient.
[0029]FIG. 4 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 45 and an antibody in the serum of a patient.
[0030]FIG. 5 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 46 and an antibody in the serum of a patient.
[0031]FIG. 6 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 47 and an antibody in the serum of a patient.
[0032]FIG. 7 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 49 and an antibody in the serum of a patient.
[0033]FIG. 8 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 51 and an antibody in the serum of a patient.
[0034]FIG. 9 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 53 and an antibody in the serum of a patient.
[0035]FIG. 10 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 55 and an antibody in the serum of a patient.
[0036]FIG. 11 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 57 and an antibody in the serum of a patient.
[0037]FIG. 12 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 58 and an antibody in the serum of a patient.
[0038]FIG. 13 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 60 and an antibody in the serum of a patient.
[0039]FIG. 14 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 62 and an antibody in the serum of a patient.
[0040]FIG. 15 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 64 and an antibody in the serum of a patient.
[0041]FIG. 16 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 66 and an antibody in the serum of a patient.
[0042]FIG. 17 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 68 and an antibody in the serum of a patient.
[0043]FIG. 18 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 70 and an antibody in the serum of a patient.
[0044]FIG. 19 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 72 and an antibody in the serum of a patient.
[0045]FIG. 20 shows results of Western blotting analysis showing reactivity of an antigenic polypeptide expressed by a polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 74 and an antibody in the serum of a patient.
BEST MODE FOR CARRYING OUT THE INVENTION
[0046]Hereafter, the present invention will be described in detail. The present application claims a priority from Japanese Patent Application No. 2004-95732 filed on Mar. 29, 2004, and the entire contents disclosed in the specification and/or drawings thereof are hereby incorporated.
1. Novel Human Solid Cancer Antigenic Polypeptides
[0047]The present invention is based on novel antigenic polypeptides that are specific to human solid cancer. With the consent of colorectal cancer patients, the present inventors extracted proteins from normal tissue and cancer tissue of surgical samples taken from the patients, followed by analysis via two-dimensional electrophoresis (e.g., Electrophoresis 22: 3019-3025, 2001). Thus, we have found 20 types of antigenic polypeptides (set forth in numbers 1 to 20 in table 1) that are specifically expressed in solid cancer cells and that have not been known to have the function as tumor markers (see Example 1). In addition, serum obtained from esophageal cancer, gastric cancer, colorectal cancer, and breast cancer patients with their consent was analyzed by a SEREX method (Proc. Natl. Acad. Sci. USA 92: 11810-11813, 1995; U.S. Pat. No. 5,698,396). Accordingly, we have also found antigenic polypeptides (set forth in numbers 21 to 39 in table 1) against 19 types of specific antibodies that exist exclusively in serum of esophageal cancer, gastric cancer, colorectal cancer, and breast cancer patients (see Example 2). These solid cancer antigenic polypeptides are shown in table 1.
TABLE-US-00001 TABLE 1 Registered Nucleotide Amino acid No. Name number sequence sequence Clone name 1 Malate dehydrogenase 2 NP_005909, 1 2 NM_005918 2 Tropomyosin 4 NP_003281, 3 4 NM_003290 3 FK506 binding protein 4 NP_002005, 5 6 NM_002014 4 Chaperonin-containing TCP1, subunit 6A NP_001753, 7 8 NM_001762 5 Serine protease inhibitor, clade H, NP_001226, 9 10 collagen binding protein 1 NM_001235 6 Sulfide dehydrogenase-like NP_067022, 11 12 NM_021199 7 Hydroxysteroid(17-β)dehydrogenase 4 NP_000405, 13 14 NM_000414 8 Stress-induced-phosphoprotein 1 NP_006810, 15 16 NM_006819 9 Heterogeneous nuclear ribonucleoprotein L NP_001524, 17 18 NM_001533 10 Heterogeneous nuclear ribonucleoprotein U NP_004492, 19 20 NM_004501 11 Matrine 3 NP_061322, 21 22 NM_018834 12 Annexin A3 NP_005130, 23 24 NM_005139 13 PTK9L protein tyrosine kinase 9-like NP_009215, 25 26 NM_007284 14 splicing factor, arginine/serine-rich 1 NP_008855, 27 28 NM_006924 15 Thiosulfate sulphurtransferase NP_003303, 29 30 NM_003312 16 S-adenosylhomocysteine hydrolase NP_000678, 31 32 NM_000687 17 GDP-mannose 4,6-dehydratase NP_001491, 33 34 NM_001500 18 Hydroxyacyl dehydrogenase, NP_000173, 35 36 subunit A NM_000182 19 Prolyl-4-hydroxylase β subunit NP_000909, 37 38 NM_000918 20 Peroxyredoxin 5 NP_036226, 39 40 NM_012094 21 Progesterone receptor membrane component 2 NM_006320 41 42 K35-1-1 22 MAP kinase interacting serine/threonine NM_199054 43 44 K30-1-1 kinase 2 23 EST: 601191782F1 BE264462 45 12N3-1 24 EST: 602301679F1 BG032310 46 12O1-1 25 Additional sex combs-like 1 NM_015338 47 48 14A1-1-1 26 Forkhead box A1 NM_004496 49 50 18G3-1 27 Retinoic acid induced 16 NM_022749 51 52 19C1-1 28 RIKEN cDNA 5730528L13-like gene NM_080655 53 54 19F1-1 29 Lysine tRNA synthase BC004132 55 56 19F1-2 30 EST: AGENCOURT_15657942 CF597227 57 6BD3-1 31 KDEL endoplasmic reticulum protein NM_006801 58 59 14H1-2-1 retention receptor 1 32 Lysosomal associated protein transmembrane NM_018407 60 61 18B2-1 4 beta 33 Protein phosphatase 1, NM_002708 62 63 18G1-1 catalytic subunit, α isoform 34 Peroxyredoxin 3 NM_006793 64 65 20J4-1 35 Aldo-keto reductase family 1, member C3 NM_003739 66 67 19M2 36 Ubiquitin-conjugating enzyme E2I BC000744 68 69 10Q3-1 37 Phosphatidic acid phosphatase, Type 2C NM_003712 70 71 14A1-1-2 38 Beta-catenin interacting protein 1 NM_020248 72 73 14B1-2-1 39 Sorting nexin 15 NM_147777 74 75 14H2-1-1
[0048]Note that, in accordance with the present invention, the term "polypeptide(s)" means molecules such as proteins and peptides, which are composed of a plurality of amino acid residues that are bound to one another via an amide bond (peptide bond). Also, the term "polynucleotide" means a molecule in which a plurality of phosphate esters of nucleosides each having a purine or pyrimidine that is bind to a sugar via a β-N-glycoside bond (ATPs, GTPs, CTPs, or UTPs; or dATPs, dGTPs, dCTPs, or dTTPs) are bound to each other.
[0049]In addition, the present invention encompasses nucleotide sequences derived from the nucleotide sequences listed in table 1 by addition, deletion, or substitution of one to several nucleotides. In addition, based on such nucleotide variation, the present invention also encompasses amino acid sequences derived from the amino acid sequences listed in table 1 by addition, deletion, or substitution of one to several amino acid residues.
[0050]Further, the term "serum antibody" means an IgG antibody that exists in the serum of a solid cancer patient and that binds to a solid cancer antigenic polypeptide. Moreover, the term "antibody" means a polyclonal or monoclonal antibody prepared by using a solid cancer antigenic polypeptide or a partial fragment thereof as an immunogen.
[0051]Other terms and concepts used in the present invention will be defined in more detail in the following embodiments and Examples. In addition, based on known literature and the like, persons skilled in the art would be readily and reliably able to use various techniques so as to carry out the present invention, except for techniques that are clearly described herein with references. For instance, preparation of pharmaceuticals for the preparation of the medicaments of the present invention is described in Remington's Pharmaceutical Sciences, 18th Edition, ed. A. Gennaro, Mack Publishing Co., Easton, Pa., 1990. Also, genetic engineering techniques and molecular biological techniques used in the present invention are described in, for example, Sambrook and Maniatis, Molecular Cloning-A Laboratory Manual, Cold Spring Harbor Laboratory Press, New York, 1989 and Ausubel, F. M. et al., Current Protocols in Molecular Biology, John Wiley & Sons, New York, N.Y, 1995.
[0052]The term "solid cancer antigenic polypeptide" refers to a polypeptide expressed by any of the 39 genes or ESTs (Expressed Sequence Tags) shown in table 1. These gene products are known to have various functions; however, their specific expression in solid cancer has not been known. Herein, in accordance with the present invention, an expression product of an EST is defined as a "polypeptide encoded by a polynucleotide comprising the nucleotide sequence set forth in SEQ ID NO: 45, 46, or 57."
[0053]Moreover, as described in Examples below, genes and peptides set forth in SEQ ID NOS: 1 to 40 are identified via two-dimensional electrophoresis, and genes, ESTs, and peptides set forth in SEQ ID NOS: 41 to 75 are identified via the SEREX method.
2. Diagnostic Kits for Solid Cancer
[0054]As described above, solid cancer antigenic polypeptides shown in table 1 are specifically expressed in human solid cancer. Thus, it becomes possible to diagnose a subject as having human solid cancer by detecting the expression of such a solid cancer antigenic polypeptide in a sample derived from the subject.
[0055]A diagnostic kit for solid cancer of the present invention (hereafter sometimes referred to as "the present diagnostic kit for solid cancer") includes a means of detecting the expression of at least one human solid cancer antigenic polypeptide in a sample derived from a subject.
[0056]The present diagnostic kit for solid cancer is a reagent kit used to make a diagnosis of solid cancer. A variety of such kits are commercially available in accordance with types of test components. Also, the present diagnostic kit for solid cancer may comprise components used in publicly known kits, except that a means of detecting the expression of a human solid cancer antigenic polypeptide is used (e.g., solid cancer antigenic polypeptides, antibodies, primers, and probes).
[0057]Further, with the use of the present diagnostic kit for solid cancer, it is possible to diagnose a subject as having solid cancer. Examples of solid cancer include, but are not limited to, colorectal cancer, esophageal cancer, gastric cancer, lung cancer, kidney cancer, thyroid cancer, parotid gland cancer, head and neck cancer, soft tissue and bone sarcoma, urinary tract cancer, bladder cancer, uterine cancer, liver cancer, breast cancer, ovarian cancer, and fallopian tube cancer. Preferably, the kit can be used for diagnosis of colorectal cancer, esophageal cancer, gastric cancer, or breast cancer.
[0058]Herein, examples of a means of detecting the expression of a solid cancer antigenic polypeptide, the protein expression thereof, the antibody expression thereof, and the gene expression thereof include: [0059](1) an antibody against the solid cancer antigenic polypeptide; [0060](2) a solid cancer antigenic polypeptide; and [0061](3) a probe or primer designed based on a polynucleotide encoding the solid cancer antigenic polypeptide.Hereafter, these means will be described in detail.
(1) Antibody Against a Solid Cancer Antigenic Polypeptide
[0062]An antibody against a solid cancer antigenic polypeptide is able to bind to a solid cancer antigenic polypeptide expressed in cancer. Thus, by detecting the reaction between the antibody and a solid cancer antigenic polypeptide in a sample, it is possible to diagnose whether or not the sample is derived from a cancer patient or a subject at high risk of developing solid cancer.
[0063]An antibody against a solid cancer antigenic polypeptide can be a polyclonal or monoclonal antibody. Examples thereof include an entire molecule and Fab, F(ab')2, and Fv fragments that can bind to the epitope of a solid cancer antigenic polypeptide. For instance, in the case of a polyclonal antibody, such antibody can be obtained by immunizing an animal with an immunogen such as an antigenic polypeptide or a partial fragment thereof and recovering from the serum of the animal. Alternatively, such antibody can be prepared by administering the expression vector for eukaryotic cells described above into the muscle or skin of an animal via injection or a gene gun, and collecting the serum. Examples of such animal include mice, rats, rabbits, goats, and chickens.
[0064]Further, the monoclonal antibody can be produced in accordance with a known method for producing monoclonal antibodies ("Monoclonal Antibody (Tan-Clone Kotai)," cowritten by Hideaki Nagamune and Hiroshi Terada, Hirokawa Shoten, 1990; "Monoclonal Antibody" James W. Goding, third edition, Academic Press, 1996).
[0065]Furthermore, an antibody against a solid cancer antigenic polypeptide can be an antibody labeled with a labeling substance. The details of such labeled antibody are described above.
[0066]When the expression of a solid cancer antigenic polypeptide in a sample derived from a subject is detected using an antibody against a solid cancer antigenic polypeptide and diagnosis of human solid cancer is carried out, the sample derived from the subject is examined for the presence or absence of an antibody against a solid cancer antigenic polypeptide or an antigenic polypeptide that binds to a labeled antibody thereof. If the antigenic polypeptide is detected in the sample, the subject is determined to be a solid cancer patient or a subject at high risk of developing solid cancer. That is, the antibody or labeled antibody used herein specifically binds to an antigenic polypeptide expressed in a solid cancer cell. Thus, a sample comprising an antigenic polypeptide that is bound to an antibody can be determined as a sample of a solid cancer patient or a subject at high risk of developing solid cancer. In such case, preferably 2 or more, more preferably 5 or more, even more preferably 10 or more, most preferably 15 to 39 antibodies are examined in terms of binding with antigenic polypeptides in a sample. Such sample to be used is not particularly limited as long as a solid cancer antigenic polypeptide is expressed therein. Examples thereof include blood, hemocytes (e.g., mononuclear cells), and tissue.
[0067]In another embodiment, a method wherein an antibody and an antigenic polypeptide are allowed to bind to each other in a liquid phase system is used. For instance, a labeled antibody is allowed to come into contact with a sample such that the labeled antibody and an antigenic polypeptide bind to each other. Then, such conjugate is separated such that a signal from the label is detected in a manner similar to that described above.
[0068]In another method of diagnosis in a liquid phase system, an antibody (primary antibody) against a solid cancer antigenic polypeptide is allowed to come into contact with a sample such that a primary antibody and the antigenic polypeptide bind to each other. Then, a labeled antibody (secondary antibody) is allowed to bind to the thus obtained conjugate such that the signal from the label of the conjugate comprising the three components is detected. Alternatively, in order to intensify the signal, an unlabeled secondary antibody is allowed to bind to a conjugate of an antibody and an antigenic polypeptide such that a labeling substance may be allowed to bind to the secondary antibody. For instance, such binding of a labeling substance to a secondary antibody can be carried out in a manner such that a secondary antibody and a labeling substance are preliminarily biotinylated and avidinylated, respectively. Also, an antibody (tertiary antibody) that recognizes a partial region of a secondary antibody (e.g., Fc region) is used for labeling so that the tertiary antibody is allowed to bind to the secondary antibody. In addition, as a primary antibody and a secondary antibody, a monoclonal antibody can be used. Alternatively, either the primary antibody or the secondary antibody may be a polyclonal antibody. Separation of such conjugate from a liquid phase and signal detection can be carried out in a manner similar to that described above.
[0069]In another embodiment, a method for examining binding between an antibody and an antigenic polypeptide in a solid phase system is used. The method involving a solid phase system is preferable in terms of detection of minute amounts of antigenic polypeptides and facilitation of operations. That is, in accordance with the method involving a solid phase system, antibodies (primary antibodies) against solid cancer antigenic polypeptides are immobilized on a solid phase (e.g., a resin plate, a membrane, or beads), antigenic polypeptides are allowed to bind to the thus immobilized antibodies, unbound peptides are removed by washing, labeled antibodies (secondary antibodies) are allowed to bind to conjugates of the antibody and the antigenic polypeptide remaining on the plate, for example, and signals of the secondary antibodies are detected. This method is a so-called "sandwich method." Such method is widely used as "ELISA (enzyme linked immunosorbent assay)" using an enzyme as a marker. In the method, the both primary antibody and the secondary antibody may be monoclonal antibodies. Alternatively, either the primary antibody or the secondary antibody may be a polyclonal antibody. Signal detection can be carried out in a manner similar to that described above.
(2) Solid Cancer Antigenic Polypeptide
[0070]Since solid cancer antigenic polypeptides are expressed by cancer cells, the serum of a patient having cancer contains an antibody (serum antibody) against an expressed solid cancer antigenic polypeptide. Thus, by examining the reaction between a solid cancer antigenic polypeptide and a serum antibody, the expression of a solid cancer antigenic polypeptide in a subject can be detected. Examples of such solid cancer antigenic polypeptide that can be used include the antigenic polypeptides shown in table 1 and partial peptides thereof. Herein, the term "antigenic polypeptide" means the antigenic polypeptides shown in table 1, and also partial peptides of the antigenic polypeptides that comprise at least 6 amino acids, preferably 6 to 500 amino acids, and more preferably 8 to 50 amino acids.
[0071]These antigenic polypeptides can be prepared by preparing RNA via in vitro transcription from a recombinant expression vector comprising a polynucleotide having a nucleotide sequence listed in table 1, for example, carrying out in vitro translation using the RNA as a template, and expressing an antigenic peptide in vitro. Alternatively, when a recombinant expression vector is introduced into a prokaryotic cell such as E coli. or Bacillus subtilis, or a eukaryotic cell such as yeast, an insect cell, or a mammalian cell such that a transformed cell is produced, it is possible to allow such transformed cell to express an antigenic polypeptide.
[0072]When an antigenic polypeptide is expressed via in vitro translation, a polynucleotide encoding an antigenic polypeptide is inserted into a vector comprising an RNA polymerase promoter to construct a recombinant expression vector. Then, the obtained vector is added to an in vitro translation system such as a rabbit reticulocyte lysate or a wheat germ extract that contains an RNA polymerase corresponding to the promoter. Thus, an antigenic polypeptide can be produced in vitro. Examples of an RNA polymerase promoter include T7, T3, and SP6. Examples of a vector comprising such RNA polymerase promoter include pKA1, pCDM8, pT3/T7 18, pT7/3 19, and pBluescript II.
[0073]When an antigenic polypeptide is allowed to be expressed in an organism such as E coli, an expression vector is produced by ligating a polynucleotide to a vector having a replication origin that is replicable in a microorganism, a promoter, a ribosome binding site, a DNA cloning site, and a terminator. A host cell is then transformed with the expression vector, and the thus obtained transformant is subjected to culture. Thus, an antigenic polypeptide encoded by the polynucleotide can be expressed using microorganisms. In such case, it is also possible to express an antigenic polypeptide as a fusion protein with another protein. Examples of an E coli. expression vector include pUC, pBluescript II, a pET expression system, and a pGEX expression system.
[0074]When an antigenic polypeptide is allowed to be expressed in a eukaryotic cell, a recombinant vector is produced by inserting a polynucleotide encoding an antigenic polypeptide into a eukaryotic cell expression vector having a promoter, a splicing region, a poly(A) addition site, and the like. Then, the recombinant vector is introduced into a eukaryotic cell. Accordingly, the antigenic polypeptide can be expressed in the transformed eukaryotic cell. Examples of such expression vector include pKA1, pCDM8, pSVK3, pMSG, pSVL, pBK-CMV, pBK-RSV, EBV vector, pRS, pcDNA3, pMSG, and pYES2. In addition, when pIND/V5-His, pFLAG-CMV-2, pEGFP-N1, pEGFP-C1, and the like are used as expression vectors, it is also possible to express an antigenic polypeptide as a fusion protein to which various types of tags such as a His tag, a FLAG tag, a myc tag, an HA tag, and GFP have been added. Examples of such eukaryotic cell that is generally used include cultured mammalian cells such as monkey kidney cells COST and Chinese hamster ovary (CHO) cells, budding yeast, fission yeast, silkworm cells, and Xenopus oocytes. In addition, any eukaryotic cell may be used as long as it can express an antigenic polypeptide. When an expression vector is introduced into a eukaryotic cell, known methods such as an electroporation method, a calcium phosphate method, a liposome method, and a DEAE-dextran method may be used.
[0075]When isolation and purification of an antigenic polypeptide of interest from a culture product is carried out following expression of the antigenic polypeptide using prokaryotic cells or eukaryotic cells, known separation techniques can be used in combination. Examples thereof include treatment using a denaturing agent such as urea or a surfactant, ultrasonication, enzymatic digestion, salting-out or solvent precipitation, dialysis, centrifugation, ultrafiltration, gel filtration, SDS-PAGE, isoelectric focusing, ion exchange chromatography, hydrophobic chromatography, affinity chromatography, and reversed phase chromatography.
[0076]In addition, recombinant antigenic polypeptides obtained via the methods described above include a fusion protein of such polypeptide and any other protein. For instance, such fusion protein comprises glutathione S-transferase (GST) or green-fluorescent protein (GFP). Further, peptides expressed in transformed cells are sometimes subjected to various forms of post-translational modification in the cells. Thus, modified peptides can be used as antigenic polypeptides. Examples of such post-translational modification include removal of N-terminal methionine, N-terminal acetylation, glycosylation, partial hydrolysis due to intracellular protease, myristoylation, isoprenylation, and phosphorylation.
[0077]In order to detect the expression of a solid cancer antigenic polypeptide in a sample derived from a subject using solid cancer antigenic polypeptides, the presence or absence of at least one serum antibody in a sample of a subject that binds to a solid cancer antigenic polypeptide is examined. If the serum antibody is found in the serum of the subject, the subject is determined to be a solid cancer patient or a subject at high risk of developing solid cancer. Specifically, solid cancer antigenic polypeptides bind to serum antibodies (IgG) derived from a solid cancer patient. Thus, when such polypeptides are allowed to react with the serum of a subject, the serum sample is found to contain serum antibodies that are bound to the polypeptides, the sample can be determined to be derived from a solid cancer patient or a subject at high risk of developing solid cancer. In such case, 2 or more, preferably 5 or more, more preferably 10 or more, and most preferably 15 to 39 antigenic polypeptides are examined in terms of binding with antibodies. Further, other known solid cancer markers (e.g., CEA, Cyfra, and SCC-Ag) can be used in combination. Moreover, the sample may be a serum antibody-containing sample, which in turn indicates serum.
[0078]Specifically, diagnosis using the present diagnostic kit for solid cancer is carried out by allowing serum of a subject to come into contact with, for example, solid cancer antigenic polypeptides in the diagnostic kit for solid cancer so as to allow the solid cancer antigenic polypeptides to react with IgG antibodies in the serum of the subject in a liquid phase. Further, labeled IgG antibodies that specifically bind to serum IgG antibodies are subjected to reaction such that signals of the labeled IgG antibodies can be detected. Examples of labels used in labeled antibodies include enzymes, radioisotopes, and fluorescent dyes. Such enzymes are not particularly limited as long as they satisfy conditions such as a large turnover number, stability even while being bound to antibodies, and capacity to cause color development specifically to a substrate. Examples of the enzymes that can be used include enzymes used in usual enzyme immunoassay (EIA) such as peroxidase, β-galactosidase, alkaline phosphatase, glucose oxidase, acetylcholine esterase, glucose-6-phosphodehydrogenase, and malate dehydrogenase. Also, enzyme inhibitors, coenzymes, and the like can be used. Binding between these enzymes and antibodies can be carried out by known methods using crosslinkers such as maleimide compounds. As the substrate, known substances can be used depending on the type of enzyme used. For instance, when peroxidase is used as the enzyme, 3,3',5,5'-tetramethylbenzene can be used, and when alkaline phosphatase is used as the enzyme, paranitrophenol or the like can be used.
[0079]When such enzyme is used, enzyme activity is determined by adding a substrate that causes color development as a result of degradation via enzymatic action so as to optically measure the amount of the substrate degraded. Then, the obtained enzyme activity is converted into an amount of binding antibody such that the amount of antibody is calculated based on comparison with a standard.
[0080]Examples of radioisotopes that can be used include 125I and 3H, which are used in general radioimmunoassay (RIA). When such a radioisotope is used, the radiation dose of the radioisotope is measured using a scintillation counter or the like.
[0081]Examples of fluorescent dyes that can be used include fluorescein isothiocyanate (FITC) and tetramethylrhodamine isothiocyanate (TRITC), which are used in general fluorescent antibody methods. When such a fluorescent dye is used, the fluorescence level may be measured using a measuring apparatus equipped with a fluorescence microscope.
[0082]Further, examples of labeled antibodies include antibodies to which metals such as manganese and iron are bound. By carrying out in vivo administration of such antibodies to which metals are bound so as to measure the metals via MRI or the like, the presence of serum antibodies, or the expression of solid cancer antigenic polypeptides, can be detected.
[0083]Signal detection can be carried out by employing Western blotting analysis, for example. Alternatively, a conjugate of an antigenic polypeptide, a serum antibody, and a labeled IgG antibody is separated by a known separation means (e.g., chromatography, a salting out, an alcohol precipitation, an enzymatic method, or a solid phase method) such that signals of the labeled IgG antibody may be detected.
[0084]In addition, at least one antigenic polypeptide is immobilized on a solid phase (e.g., plates, membranes, and beads) such that binding between serum antibodies of a subject and the antigenic polypeptides can be examined on the solid phase. By immobilizing antigenic polypeptides on a solid phase, it becomes possible to readily remove unbound labeled binding molecules. In particular, in accordance with a protein array method wherein a membrane on which several tens of different types of antigenic polypeptides are immobilized is used, different types of a plurality of antibodies can be analyzed in terms of expression in a short time using about 0.01 ml of the serum of a subject.
(3) Primers or Probes
[0085]The present diagnostic kit for solid cancer may comprise a primer or probe that comprises polynucleotide consisting of the entire or a partial sequence of a polynucleotide encoding a solid cancer antigenic polypeptide shown in table 1 or a complementary sequence thereof. The primer or probe specifically binds to mRNA of the antigenic polypeptide expressed in the sample of a subject or cDNA synthesized from the mRNA. Thus, it is possible to detect the expression of a gene encoding an antigenic polypeptide in a sample, which in turn indicates the expression of the antigenic polypeptide.
[0086]Such primer and probe can be designed in accordance with techniques known by persons skilled in the art based on nucleotide sequences of polynucleotides encoding antigenic polypeptides, which are set forth in SEQ ID NOS:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 46, 47, 49, 51, 53, 55, 57, 58, 60, 62, 64, 66, 68, 70, 72, and 74. The following remarks relate to the designing of such primer and probe.
[0087]The length of the primer that substantially have its function is preferably 10 or more nucleotides, more preferably 16 to 50 nucleotides, and even more preferably 20 to 30 nucleotides. In addition, the length of the probe that substantially have its function is preferably 10 or more nucleotides, more preferably 16 to 50 nucleotides, and even more preferably 20 to 30 nucleotides.
[0088]Upon design, it is preferable to confirm the melting temperature of a primer or probe (Tm). The "Tm" means the temperature at which 50% of an arbitrary polynucleotide chain forms a hybrid with the complementary strand thereof. When template DNA or RNA and a primer or probe anneal or hybridize by forming a duplex, the temperature for annealing or hybridization must be optimized. Meanwhile, when the temperature is excessively decreased, nonspecific reaction takes place. Thus, the temperature is preferably as high as possible. Therefore, the Tm of the primer or probe to be designed is an important factor when carrying out amplification reaction or hybridization. The Tm can be confirmed with the use of known software for designing a primer or probe. Examples of such software that can be used in the present invention include Oligo® (National Bioscience Inc., (U.S.A.)) and GENETYX (Software Development Co., Ltd. (Japan)). In addition, the Tm can be confirmed by manual calculation without using such software. In such case, calculating formulae based on the nearest neighbor base pair model (nearest neighbor method), the Wallace method, the GC % method, and the like can be used. In accordance with the present invention, the average Tm is preferably about 45° C. to 55° C.
[0089]Another example of conditions under which a primer or probe can be specifically anneals or hybridizes involves GC content or the like. Such condition has been known by persons skilled in the art.
[0090]The primer and the probe designed as described above can be prepared in accordance with methods known by persons skilled in the art. Further, as known by persons skilled in the art, such primer or probe may contain a sequence such as an additional sequence known as a tag sequence in addition to the sequence for annealing or hybridization. Also, the aforementioned primer or probe to which such additional sequence has been added is within the scope of the present invention.
[0091]When expression of solid cancer antigenic polypeptides in a sample derived from a subject is detected, the aforementioned primer and/or probe are used in an amplification reaction or a hybridization reaction, such that the amplification product or hybridization product thereof is detected.
[0092]Examples of such sample of interest include feces, blood, and hemocytes (e.g., mononuclear cells). In addition, when carrying out an amplification reaction or a hybridization reaction, a nucleic acid to be tested is prepared from a sample derived from a subject, in general. The test nucleic acid may be DNA or RNA, as long as it is nucleic acid. DNA or RNA can be extracted using methods known in the art according to need. For instance, upon DNA extraction, a method of carrying out phenol extraction and ethanol precipitation and a method using glass beads can be used. Also, upon RNA extraction, a guanidine-cesium chloride ultracentrifugation method, a hot phenol method, an acid guanidinium thiocyanate-phenol-chloroform (AGPC) method, or the like can be used. With the use of a sample or test nucleic acid prepared as described above, an amplification reaction and/or a hybridization reaction described below is carried out.
[0093]Expression of a solid cancer antigenic polypeptide in a sample can be detected by carrying out amplification with the use of a primer and test nucleic acid as a template and detecting the specific amplification reaction.
[0094]Amplification methods are not particularly limited. However, examples thereof include known methods utilizing principles of polymerase chain reaction (PCR) methods such as PCR, LAMP (loop-mediated isothermal amplification), ICAN (isothermal and chimeric primer-initiated amplification of nucleic acids), RCA (rolling circle amplification), LCR (ligase chain reaction), and SDA (strand displacement amplification). Amplification is carried out until an amplification product can be detected.
[0095]For instance, upon PCR, a nucleotide sequence between a pair of primers is synthesized based on a template, DNA to be tested, using DNA polymerase. Upon PCR, amplified fragments can be exponentially amplified with the repetition of a cycle consisting of denaturation, annealing, and synthesis. Optimal conditions for PCR can readily be determined by persons skilled in the art.
[0096]In addition, upon RT-PCR, cDNA is produced via reverse transcriptase reaction using RNA to be tested as a template, followed by PCR using a pair of primers and the thus prepared cDNA that serves as a template.
[0097]In addition, with the use of amplification techniques such as quantitative PCR including competitive PCR and real-time PCR, quantitative detection can be achieved.
[0098]In order to detect whether or not the aforementioned amplification reaction is a specific amplification reaction, known methods whereby amplification products obtained via an amplification reaction can be specifically recognized can be used. For instance, a specific amplification reaction can be detected using agarose gel electrophoresis whereby amplification of amplified fragments in given sizes is confirmed.
[0099]Alternatively, labels such as radioisotopes, fluorescent substances, or luminescent substances are allowed to act on dNTP that is incorporated during an amplification reaction such that such label can be detected. Examples of radioisotopes that can be used include 32P, 125I, and 35S. Examples of fluorescent substances that can be used include fluorescein (FITC), sulforhodamine (SR), and tetramethylrhodamine (TRITC). In addition, examples of luminescent substances that can be used include luciferin.
[0100]For instance, the label type and the method for introducing a label are not particularly limited. Thus, conventionally known methods can be used. Examples of the method for introducing a label include a random prime method using a radioisotope.
[0101]As a method for observing an amplification product into which labeled dNTP has been incorporated, any methods for detecting aforementioned labels known in the art can be used. For instance, when a radioisotope is used as a label, the radioactivity can be measured using a liquid scintillation counter, a γ-counter, or the like. When fluorescence is used as a label, the fluorescence can be detected using a fluorescence microscope, a fluorescent plate reader, or the like.
[0102]When a specific amplification reaction is detected as described above, a gene encoding a solid cancer antigenic polypeptide is expressed in a sample, which in turn indicates the expression of a solid cancer antigenic polypeptide. Thus, a subject whose sample shows antigenic polypeptide expression is determined to be a solid cancer patient or subject at high risk of developing solid cancer.
[0103]In addition, a sample or test nucleic acid is subjected to a hybridization reaction using a probe, followed by detection of the specific binding (hybrid). Thus, the expression of solid cancer antigenic polypeptides can be detected.
[0104]The hybridization reaction must be carried out under stringent conditions that allow a probe to specifically bind to a polynucleotide derived from a solid cancer antigenic polypeptide. Such stringent conditions have been known in the art and thus are not particularly limited. The stringent conditions include a sodium concentration of 10 to 300 mM and preferably 20 to 100 mM and a temperature of 25° C. to 70° C. and preferably 42° C. to 55° C.
[0105]When carrying out hybridization, it is possible to add appropriate labels such as fluorescence labels (e.g., fluorescein and rhodamine), radioactive labels (e.g., 32P), enzyme labels (e.g., alkaline phosphatase and horseradish peroxidase), and biotin labels to a probe. Thus, the present diagnostic kit for solid cancer comprises probes to which labels as described above have been attached.
[0106]Detection using labeled probes includes allowing a sample or test nucleic acid that has been prepared from the sample to come into contact with a probe so as to achieve hybridization. The expression "so as to achieve hybridization" indicates that detection is carried out in an environment (temperature and salt concentration) in which specific binding occurs under the stringent conditions described above. Specifically, a sample or test nucleic acid is immobilized on an adequate solid phase such as a slide glass, a membrane, or a microtiter. Then, labeled probes are added thereto. Thus, a sample or test nucleic acid is allowed to come into contact with the probes such that hybridization reaction is carried out, followed by removal of the nonhybridized probes. Accordingly, the label of the probe that has hybridized with the sample or test nucleic acid is detected. Detection of the label indicates that solid cancer antigenic polypeptides are expressed in the sample. Therefore, a subject whose sample shows expression of an antigenic polypeptide is diagnosed as being a solid cancer patient or a subject at high risk of developing solid cancer.
[0107]In addition, when the concentration of the label is determined to be an index, it is also possible to carry out quantitative detection. Examples of a detection method using labeled probes include Southern hybridization, Northern hybridization, and. FISH (fluorescent in situ hybridization).
[0108]Further, when the present diagnostic kit for solid cancer is used to make a diagnosis, the expression level of solid cancer antigenic polypeptides in a sample derived from a subject is measured. If the expression level of at least one solid cancer antigenic polypeptide is higher than that of a healthy individual, the subject is determined to be a solid cancer patient or subject at high risk of developing solid cancer. In terms of specific criteria for the expression level of a solid cancer antigenic polypeptide, the expression level of a subject is 10% or more, preferably 30% or more, more preferably 70% or more, and most preferably 100% or more higher than the expression level of a healthy individual.
3. Medicament for Preventing or Treating Solid Cancer
3.1. Inhibition of Functions or Expression of Solid Cancer Antigenic Polypeptide
[0109]Solid cancer antigenic polypeptides are specifically expressed in solid cancer. Thus, such expression very probably causes malignant cell transformation. Therefore, it is expected that therapeutic effects against malignant cell transformation or progress in such transformation can be obtained by inhibiting the functions or the expression of a solid cancer antigenic polypeptide.
[0110]Accordingly, a means of inhibiting the functions and the expression of at least one human solid cancer antigenic polypeptides described above is effective as a medicament for preventing and/or treating solid cancer.
[0111]Examples of such means of inhibiting the functions or the expression of a human solid cancer antigenic polypeptide include: [0112](1) an antibody against the solid cancer antigenic polypeptide; [0113](2) a means capable of inhibiting transcription of a gene encoding the solid cancer antigenic polypeptide; and [0114](3) a means capable of inhibiting translation of a gene encoding the solid cancer antigenic polypeptide.
(1) Antibodies Against Solid Cancer Antigenic Polypeptides
[0115]Antibodies against solid cancer antigenic polypeptides can inhibit activities of the antigenic polypeptides by specifically binding to solid cancer antigenic polypeptides in a subject. Thus, medicaments comprising antibodies against solid cancer antigenic polypeptides are effective for prevention or therapy of solid cancer.
(2) Means Capable of Inhibiting Transcription of a Gene Encoding a Solid Cancer Antigenic Polypeptide
[0116]Examples of a means of inhibiting transcription of a gene encoding a solid cancer antigenic polypeptide include expression vectors that can be used for substitution of transcriptional promoter regions of the genes in a subject with transcriptional repression-type promoters. In addition, as a means of inhibiting transcription of a gene encoding a solid cancer antigenic polypeptide, expression vectors may be used, with which a nucleotide sequence having transcriptional repression activity is inserted into a region involving translation of the gene. Design and preparation of such expression vectors have been known to persons skilled in the art.
(3) Means Capable of Inhibiting Translation of a Gene Encoding a Solid Cancer Antigenic Polypeptide
[0117]In addition, examples of a means of inhibiting translation of a gene encoding a solid cancer antigenic polypeptide include a method using a so-called antisense RNA. Specifically, a nucleic acid transcribing antisense RNA corresponding to mRNA of a gene is introduced as a plasmid or incorporated into a genome of a subject such that the antisense RNA is allowed to be overexpressed, resulting in inhibition of translation of mRNA of a gene encoding a solid cancer antigenic polypeptide. Techniques related to antisense RNA have been known to be used in cases where mammals and the like are used as hosts (Han et al. (1991) Proc. Natl. Acad. Sci. USA, 88, 4313-4317; Hackett et al. (2000) Plant Physiol., 124, 1079-86).
[0118]Further, it is also possible to utilize RNA interference so as to inhibit translation of a gene encoding a solid cancer antigenic polypeptide. Specifically, double-stranded RNA complementary to a nucleotide sequence of a gene encoding a target solid cancer antigenic polypeptide is introduced into a cell such that mRNA of an endogenous gene encoding a solid cancer antigenic polypeptide is degraded, resulting in specific inhibition of gene expression in the cell. Such technique has been found available in the cases of mammalian cells and the like (Hannon, G J., Nature (2002) 418, 244-251 (review); JP Patent Publication No. 2002-516062 A; JP Patent Publication No. 8-506734 A (1996)).
3.2. Targeting to Solid Cancer
[0119]Since solid cancer antigenic polypeptides are specifically expressed in solid cancer, it becomes possible to allow therapeutic agents for solid cancer to act on cancer lesions with the use of a means of targeting to solid cancer based on such specific expression.
[0120]Thus, the means of targeting to solid cancer described above is also effective as a medicament for preventing and/or treating solid cancer. The medicament for preventing and/or treating solid cancer of the present invention includes a gene encoding a prophylactic or therapeutic agent for solid cancer and a means of targeting to human solid cancer.
[0121]Examples of such means of targeting to human solid cancer include: [0122](1) an antibody against a solid cancer antigenic polypeptide; and [0123](2) a nucleotide sequence of an expression control region of a polynucleotide encoding a solid cancer antigenic polypeptide.
(1) Antibodies Against Solid Cancer Antigenic Polypeptides
[0124]Antibodies against solid cancer antigenic polypeptides bind to the antigenic polypeptides that are specifically expressed in cancer cells. Thus, when known agents for solid cancer therapy (e.g., anticancer drugs or immunopotentiating agents) are linked to such antibodies so as to be administered to patients, it is possible to allow the agents for solid cancer therapy to specifically act on cancer cells.
(2) Nucleotide Sequences of Expression Control Regions of Polynucleotides Encoding Solid Cancer Antigenic Polypeptides
[0125]Expression control regions of polynucleotides encoding solid cancer antigenic polypeptides (hereafter to be referred to as "promoter sequence(s)") are expression control regions of genes that are specifically expressed in solid cancer cells. Thus, when therapeutic genes are produced by ligating polynucleotides encoding agents for solid cancer therapy to a promoter sequence and are administered in vivo, it becomes possible to allow such therapeutic genes to be expressed in a cancer cell-specific manner. Examples of polynucleotides encoding substances having an anticancer effect or precursors thereof that can be used include DNA and cDNA of genes encoding p53, herpes simplex virus thymidine kinase, interleukin-2,-12,-17,-18, cytosine deaminase, uracil phosphoribosyltransferase, and the like. Moreover, such promoter sequences can be used in a therapeutic method wherein adenovirus and herpes virus are proliferated in a cancer-cell-specific manner such that cancer cells are degraded. That is, by inserting promoter sequence before the adenovirus E1A region, such adenovirus is allowed to specifically proliferate exclusively in cancer cells such that cancer cells are degraded.
3.3. Application and Administration of Medicament
[0126]Examples of solid cancer to which the medicament of the present invention is applied include, but are not limited to, colorectal cancer, esophageal cancer, gastric cancer, lung cancer, kidney cancer, thyroid cancer, parotid gland cancer, head and neck cancer, soft tissue and bone sarcoma, urinary tract cancer, bladder cancer, uterine cancer, liver cancer, breast cancer, ovarian cancer, and fallopian tube cancer. More specifically, such solid cancer is colorectal cancer, esophageal cancer, gastric cancer, or breast cancer.
[0127]It is possible to administer the medicament of the present invention for the purpose of preventing development of the solid cancer described above or preventing deterioration in terms of symptoms or alleviating symptoms of a patient having solid cancer or a patient who has been diagnosed as being at high risk of developing solid cancer.
[0128]When the aforementioned means is used as a medicament for treating or preventing solid cancer, it can be mixed with pharmaceutically acceptable carriers so as to be used as a pharmaceutical composition. In such case, an active ingredient of such medicament may be adequately adjusted so as to account for 1% to 90% of the carrier content.
[0129]Examples of administration routes of the medicament of the present invention include systemic administration such as intravenous or intra-arterial administration, in general. Further, it is preferable to carry out local administration such as local injection to primary cancer lesions or metastatic lesions that can be predicted based on the cancer type.
[0130]The dose of the medicament of the present invention varies depending on age, sex, symptoms, administration routes, administration frequencies, and formulations. These may be adequately adjusted by persons skilled in the art or physicians.
[0131]The present invention will be hereafter described in detail with reference to the following examples, although the scope of the present invention is not limited thereto.
Example 1
Identification of Colorectal Cancer Antigenic Polypeptides via Two-Dimensional Electrophoresis
[1] Material and Methods
[0132]With the consent of patients (6 cases), frozen specimens of cancer tissue and non-cancer tissue of each patient were separately collected immediately after colorectal cancer extraction. These frozen specimens were kept at -80° C. An adequate amount of each frozen specimen was homogenized with a solution containing 9.5 M Urea, 2% CHAPS, 1% DTT, and complete protease inhibitor cocktail tablets (Roche). The resultant was centrifuged using an ultracentrifuge (Hitachi) at 100,000 g, followed by extraction of the supernatant (protein solution) thereof. Then, protein concentration was determined based on absorbance.
[0133]Proteins obtained from cancer tissue and non-cancer tissue (400 μg each) were subjected to two-dimensional electrophoresis for separation. The first-dimensional electrophoresis and the second-dimensional electrophoresis were carried out via agarose isoelectric focusing electrophoresis and 12% or 6% to 10% Tris/Glycine SDS polyacrylamide gel electrophoresis, respectively. The thus separated proteins were stained with Coomassie Brilliant Blue R250, followed by detection of spots indicating an increased protein expression level in cancer tissue compared with that in non-cancer tissue. Then, gel containing the spots was excised, followed by digestion of proteins contained in the gel sections using trypsin (Roche). The thus obtained peptides were collected and subjected to amino acid sequence determination using an ion-trap mass spectrometer (LCQ DECA XP, ThermoQuest).
[2] Results
[0134]The results are shown in FIGS. 1A and 1B. The comparison between cancer tissue (Tumor) and normal tissue (Normal) of colorectal cancer patients (6 cases) confirmed specific expression of proteins in the cancer tissue in 4 to 6 cases. The expressed proteins had amino acid sequences set forth in SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, and 40. In FIGS. 1A and 1B, numbers assigned to encircled proteins correspond to antigenic polypeptides denoted by the numbers of 1 to 20 in table 1.
[0135]Nucleotide sequences encoding these proteins are set forth in SEQ ID NOS: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, and 39, respectively. The respective genes are shown in table 1.
Example 2
Identification of Solid Cancer Antigenic Polypeptides by a SEREX Method
[0136][1] Construction of cDNA Library
[0137]A human esophageal-cancer-derived cell line T.Tn was cultured in DMEM medium containing a 10% fetal bovine-serum supplemented with kanamycin (100 μg/ml). Then, total RNA (250 μg) was isolated from these cultured cells via a guanidinium thiocyanate-phenol-chloroform extraction method, followed by 2 repetitions of poly(A) selection using oligo-dT (Oligotex-dT30 super, TAKARA). Thus, mRNA was purified. With the use of the thus obtained mRNA (5.7 μg), a cDNA library of each cell was constructed. Single-stranded cDNA was synthesized using a XhoI linker primer and 5-methyl dCTP. Double-stranded cDNA having blunt ends was synthesized using T4 DNA polymerase based on the single-stranded cDNA. To both ends of the double-stranded cDNA, a linker containing restriction enzyme sites (EcoRI/λZAPII) was added. The obtained cDNA fragment was inserted into a bacteriophage (Stratagene). Then, a cDNA library of each cancer cell comprising about 1.8×106 clones was constructed.
[2] Screening of cDNA Library
[0138]Phage vectors of the above-prepared cDNA libraries of cancer cells were allowed to infect E coli. XL1-Blue. Then, plaque was formed on an NZY agarose plate. Each infected E coli. cell was treated with 10 mM IPTG, resulting in expression induction. Thus, peptides encoded by the various cDNAs were expressed. These peptides were transferred to a nitrocellulose filter (NitroBind, Osmonics). The filter was washed with TBS (0.5% Tween20-containing TBS (10 mM Tris-HCl, 150 mM NaCl; pH 7.5)) such that bacteriophages that had adsorbed thereto were removed. Thereafter, nonspecific reaction was suppressed using TBS-Tween containing 1% albumin. The filter was subjected to reaction with serum of patients with esophageal cancer, gastric cancer, colorectal cancer, and breast cancer at room temperature for 2 hours.
[0139]The serum isolated from each patient was kept at -80° C. and diluted 500-fold immediately before use with a TBS-Tween solution (TBS-Tween containing 0.5% polyoxyethylene sorbitan monolaurate) that contained 1% by weight albumin. The thus diluted serum was mixed with an E coli. lysate at a ratio of 1:5. The resultant was allowed to stand at 4° C. for 8 hours, followed by centrifugation at 15,000 g for 20 minutes. Then, the supernatant thereof was recovered and used. In addition, untreated serum was diluted 2000-fold and used according to need.
[0140]Each serum was subjected to reaction with the aforementioned nitrocellulose filter on which expressed peptides had been blotted at room temperature for 10 to 20 hours. Thus, polypeptides with which serum antibodies had reacted were identified. Specifically, alkaline-phosphatase-labeled anti human IgG-F (ab')2 goat antibodies (Jachson) were diluted 5000-fold and used as secondary antibodies during the reaction. Label signals were detected via enzymatic chromogenic reaction using nitroblue tetrazolium (Wako) and 5-bromo-4-chloro-3-indolyl phosphate (Wako). Colonies corresponding to chromogenic-reaction-positive were collected from the agarose plate and dissolved in SM buffer (100 mM NaCl, 10 mM MgSO4, and 50 mM Tris-HCl; pH 7.5). Until chromogenic-reaction-positive colonies became united, secondary screening and tertiary screening were repeated as described above. Thus, phage clones that reacted with serum IgG of 5 patients were subjected to screening such that positive clones were isolated.
[3] Identification of Novel Antigens
[0141]With the use of the obtained positive clones, insert DNA was replicated by PCR. The resulting product was subjected to sequencing using a Big Dye DNA Sequencing Kit (ABI) and ABI Prism (Perkin Elmer). As a result of searching based on existing databases, in addition to antigenic polypeptides that were expression products of known cancer-related genes, 19 types of novel antigenic polypeptides that reacted with serum antibodies of a plurality of patients were identified. Table 2 shows antibody prevalences among cancer patients to these novel antigenic polypeptides.
TABLE-US-00002 TABLE 2 Antibody prevalence (%) Early Esophageal esophageal Colorectal Gastric Breast Clone Registered cancer cancer cancer cancer cancer Healthy No. name Name number patient patient patient patient patient individual 1 K35-1-1 Progesterone receptor NM_006320 10 13 0 20 0 10 membrane component 2 2 K30-1-1 MAP kinase interacting NM_199054 0 13 10 20 20 5 serine/threonine kinase 2 3 12N3-1 EST: 601191782F1 BE264462 5 0 0 0 0 0 4 12O1-1 EST: 602301679F1 BG032310 15 0 10 30 0 0 5 14A1-1-1 Additional sex NM_015338 15 13 10 10 0 6 combs-like 1 6 18G3-1 Forkhead box A1 NM_004496 10 0 0 0 20 0 7 19C1-1 Retinoic acid induced 16 NM_022749 5 0 0 0 10 0 8 19F1-1 RIKEN cDNA NM_080655 5 0 40 10 10 5 5730528L13-like gene 9 19F1-2 Lysine tRNA synthase BC004132 0 13 20 20 20 0 10 6BD3-1 EST: CF597227 14 0 AGENCOURT_15657942 11 14H1-2-1 KDEL endoplasmic NM_006801 10 0 reticulum protein retention receptor 1 12 18B2-1 Lysosomal associated NM_018407 10 0 protein transmembrane 4 beta 13 18G1-1 Protein phosphatase NM_002708 10 0 1, catalytic subunit, α isoform 14 20J4-1 Peroxyredoxin 3 NM_006793 14 0 15 19M2 Aldo-keto reductase NM_003739 38 0 family 1, member C3 16 10Q3-1 Ubiquitin-conjugating BC000744 33 0 enzyme E2I 17 14A1-1-2 Phosphatidic acid NM_003712 40 21 phosphatase, Type 2C 18 14B1-2-1 Beta-catenin interacting NM_020248 33 17 protein 1 19 14H2-1-1 Sorting nexin 15 NM_147777 11 4
[0142]Polynucleotide (cDNA) sequences that encode amino acids of these 19 types of novel antigenic polypeptides have nucleotide sequences set forth in SEQ ID NOS: 41, 43, 45, 46, 47, 49, 51, 53, 55, 57, 58, 60, 62, 64, 66, 68, 70, 72, and 74, respectively. In addition, nucleotide sequences set forth in SEQ ID NOS: 41, 43, 47, 49, 51, 53, 55, 58, 60, 62, 64, 66, 68, 70, 72, and 74 have amino acid sequences set forth in SEQ ID NOS: 42, 44, 48, 50, 52, 54, 56, 59, 61, 63, 65, 67, 69, 71, 73, and 75, respectively.
[0143]FIGS. 2 to 20 show the results of Western blotting analysis that was carried out to examine binding reactions involving these 19 types of novel antigenic polypeptides and serum antibodies of the patients. In FIGS. 2 to 20, arrows indicate polypeptides that underwent specific reaction with the serum antibodies of the patients. The polypeptides were detected in the IPTG-treated E coli. extract; however, they were not detected in the untreated E coli. extract. Thus, the polypeptides were confirmed to be derived from cDNA that had been introduced thereinto.
[0144]All publications, patents, and patent applications cited herein are incorporated herein by reference in their entirety.
INDUSTRIAL APPLICABILITY
[0145]According to the diagnostic kit for solid cancer of the present invention, solid cancer can be diagnosed with high accuracy and it is useful for early diagnosis of solid cancer. In addition, with the use of the medicament for preventing or treating solid cancer of the present invention, it becomes possible to carry out a therapy whereby selective targeting of solid cancer is carried out.
Sequence CWU
1
7511321DNAHomo sapiensCDS(87)..(1103) 1ggcgctgggc agtgtggagg tcgttggagt
cacttccgcg tcaccagctc ctgtgcctgc 60cagtcggtgc ccctcccgct ccagcc atg
ctc tcc gcc ctc gcc cgg cct gcc 113 Met
Leu Ser Ala Leu Ala Arg Pro Ala 1
5agc gct gct ctc cgc cgc agc ttc agc acc tcg gcc cag aac aat gct
161Ser Ala Ala Leu Arg Arg Ser Phe Ser Thr Ser Ala Gln Asn Asn Ala10
15 20 25aaa gta gct gtg cta
ggg gcc tct gga ggc atc ggg cag cca ctt tca 209Lys Val Ala Val Leu
Gly Ala Ser Gly Gly Ile Gly Gln Pro Leu Ser 30
35 40ctt ctc ctg aag aac agc ccc ttg gtg agc cgc
ctg acc ctc tat gat 257Leu Leu Leu Lys Asn Ser Pro Leu Val Ser Arg
Leu Thr Leu Tyr Asp 45 50
55atc gcg cac aca ccc gga gtg gcc gca gat ctg agc cac atc gag acc
305Ile Ala His Thr Pro Gly Val Ala Ala Asp Leu Ser His Ile Glu Thr
60 65 70aaa gcc gct gtg aaa ggc tac ctc
gga cct gaa cag ctg cct gac tgc 353Lys Ala Ala Val Lys Gly Tyr Leu
Gly Pro Glu Gln Leu Pro Asp Cys 75 80
85ctg aaa ggt tgt gat gtg gta gtt att ccg gct gga gtc ccc aga aag
401Leu Lys Gly Cys Asp Val Val Val Ile Pro Ala Gly Val Pro Arg Lys90
95 100 105cca ggc atg acc
cgg gac gac ctg ttc aac acc aat gcc acg att gtg 449Pro Gly Met Thr
Arg Asp Asp Leu Phe Asn Thr Asn Ala Thr Ile Val 110
115 120gcc acc ctg acc gct gcc tgt gcc cag cac
tgc ccg gaa gcc atg atc 497Ala Thr Leu Thr Ala Ala Cys Ala Gln His
Cys Pro Glu Ala Met Ile 125 130
135tgc gtc att gcc aat ccg gtt aat tcc acc atc ccc atc aca gca gaa
545Cys Val Ile Ala Asn Pro Val Asn Ser Thr Ile Pro Ile Thr Ala Glu
140 145 150gtt ttc aag aag cat gga gtg
tac aac ccc aac aaa atc ttc ggc gtg 593Val Phe Lys Lys His Gly Val
Tyr Asn Pro Asn Lys Ile Phe Gly Val 155 160
165acg acc ctg gac atc gtc aga gcc aac acc ttt gtt gca gag ctg aag
641Thr Thr Leu Asp Ile Val Arg Ala Asn Thr Phe Val Ala Glu Leu Lys170
175 180 185ggt ttg gat cca
gct cga gtc aac gtc cct gtc att ggt ggc cat gct 689Gly Leu Asp Pro
Ala Arg Val Asn Val Pro Val Ile Gly Gly His Ala 190
195 200ggg aag acc atc atc ccc ctg atc tct cag
tgc acc ccc aag gtg gac 737Gly Lys Thr Ile Ile Pro Leu Ile Ser Gln
Cys Thr Pro Lys Val Asp 205 210
215ttt ccc cag gac cag ctg aca gca ctc act ggg cgg atc cag gag gcc
785Phe Pro Gln Asp Gln Leu Thr Ala Leu Thr Gly Arg Ile Gln Glu Ala
220 225 230ggc acg gag gtg gtc aag gct
aaa gcc gga gca ggc tct gcc acc ctc 833Gly Thr Glu Val Val Lys Ala
Lys Ala Gly Ala Gly Ser Ala Thr Leu 235 240
245tcc atg gcg tat gcc ggc gcc cgc ttt gtc ttc tcc ctt gtg gat gca
881Ser Met Ala Tyr Ala Gly Ala Arg Phe Val Phe Ser Leu Val Asp Ala250
255 260 265atg aat gga aag
gaa ggt gtt gtg gaa tgt tcc ttc gtt aag tca cag 929Met Asn Gly Lys
Glu Gly Val Val Glu Cys Ser Phe Val Lys Ser Gln 270
275 280gaa acg gaa tgt acc tac ttc tcc aca ccg
ctg ctg ctt ggg aaa aag 977Glu Thr Glu Cys Thr Tyr Phe Ser Thr Pro
Leu Leu Leu Gly Lys Lys 285 290
295ggc atc gag aag aac ctg ggc atc ggc aaa gtc tcc tct ttt gag gag
1025Gly Ile Glu Lys Asn Leu Gly Ile Gly Lys Val Ser Ser Phe Glu Glu
300 305 310aag atg atc tcg gat gcc atc
ccc gag ctg aag gcc tcc atc aag aag 1073Lys Met Ile Ser Asp Ala Ile
Pro Glu Leu Lys Ala Ser Ile Lys Lys 315 320
325ggg gaa gat ttc gtg aag acc ctg aag tga gccgctgtga cgggtggcca
1123Gly Glu Asp Phe Val Lys Thr Leu Lys330
335gtttccttaa tttatgaagg catcatgtca ctgcaaagcc gttgcagata aactttgtat
1183tttaatttgc tttggtgatg attactgtat tgacatcatc atgccttcca aattgtgggt
1243ggctctgtgg gcgcatcaat aaaagccgtc cttgatttta tttttcaagg tcccttctgt
1303aaaaaaaaaa aaaaaaaa
13212338PRTHomo sapiens 2Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala
Leu Arg Arg Ser1 5 10
15Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala
20 25 30Ser Gly Gly Ile Gly Gln Pro
Leu Ser Leu Leu Leu Lys Asn Ser Pro 35 40
45Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly
Val 50 55 60Ala Ala Asp Leu Ser His
Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr65 70
75 80Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys
Gly Cys Asp Val Val 85 90
95Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp
100 105 110Leu Phe Asn Thr Asn Ala
Thr Ile Val Ala Thr Leu Thr Ala Ala Cys 115 120
125Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn
Pro Val 130 135 140Asn Ser Thr Ile Pro
Ile Thr Ala Glu Val Phe Lys Lys His Gly Val145 150
155 160Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr
Thr Leu Asp Ile Val Arg 165 170
175Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val
180 185 190Asn Val Pro Val Ile
Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu 195
200 205Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln
Asp Gln Leu Thr 210 215 220Ala Leu Thr
Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala225
230 235 240Lys Ala Gly Ala Gly Ser Ala
Thr Leu Ser Met Ala Tyr Ala Gly Ala 245
250 255Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly
Lys Glu Gly Val 260 265 270Val
Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe 275
280 285Ser Thr Pro Leu Leu Leu Gly Lys Lys
Gly Ile Glu Lys Asn Leu Gly 290 295
300Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile305
310 315 320Pro Glu Leu Lys
Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr 325
330 335Leu Lys32049DNAHomo sapiensCDS(51)..(797)
3gagcccagcc gagcgtccgc cgctgcccgt gcgcctctgc gctccgcgcc atg gcc 56
Met Ala
1ggc ctc aac tcc ctg gag gcg
gtg aaa cgc aag atc cag gcc ctg cag 104Gly Leu Asn Ser Leu Glu Ala
Val Lys Arg Lys Ile Gln Ala Leu Gln 5 10
15cag cag gcg gac gag gcg gaa gac cgc gcg cag ggc ctg cag cgg
gag 152Gln Gln Ala Asp Glu Ala Glu Asp Arg Ala Gln Gly Leu Gln Arg
Glu 20 25 30ctg gac ggc gag cgc gag
cgg cgc gag aaa gct gaa ggt gat gtg gcc 200Leu Asp Gly Glu Arg Glu
Arg Arg Glu Lys Ala Glu Gly Asp Val Ala35 40
45 50gcc ctc aac cga cgc atc cag ctc gtt gag gag
gag ttg gac agg gct 248Ala Leu Asn Arg Arg Ile Gln Leu Val Glu Glu
Glu Leu Asp Arg Ala 55 60
65cag gaa cga ctg gcc acg gcc ctg cag aag ctg gag gag gca gaa aaa
296Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala Glu Lys
70 75 80gct gca gat gag agt gag aga
gga atg aag gtg ata gaa aac cgg gcc 344Ala Ala Asp Glu Ser Glu Arg
Gly Met Lys Val Ile Glu Asn Arg Ala 85 90
95atg aag gat gag gag aag atg gag att cag gag atg cag ctc aaa
gag 392Met Lys Asp Glu Glu Lys Met Glu Ile Gln Glu Met Gln Leu Lys
Glu 100 105 110gcc aag cac att gcg gaa
gag gct gac cgc aaa tac gag gag gta gct 440Ala Lys His Ile Ala Glu
Glu Ala Asp Arg Lys Tyr Glu Glu Val Ala115 120
125 130cgt aag ctg gtc atc ctg gag ggt gag ctg gag
agg gca gag gag cgt 488Arg Lys Leu Val Ile Leu Glu Gly Glu Leu Glu
Arg Ala Glu Glu Arg 135 140
145gcg gag gtg tct gaa cta aaa tgt ggt gac ctg gaa gaa gaa ctc aag
536Ala Glu Val Ser Glu Leu Lys Cys Gly Asp Leu Glu Glu Glu Leu Lys
150 155 160aat gtt act aac aat ctg
aaa tct ctg gag gct gca tct gaa aag tat 584Asn Val Thr Asn Asn Leu
Lys Ser Leu Glu Ala Ala Ser Glu Lys Tyr 165 170
175tct gaa aag gag gac aaa tat gaa gaa gaa att aaa ctt ctg
tct gac 632Ser Glu Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Leu Leu
Ser Asp 180 185 190aaa ctg aaa gag gct
gag acc cgt gct gaa ttt gca gag aga acg gtt 680Lys Leu Lys Glu Ala
Glu Thr Arg Ala Glu Phe Ala Glu Arg Thr Val195 200
205 210gca aaa ctg gaa aag aca att gat gac ctg
gaa gag aaa ctt gcc cag 728Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu
Glu Glu Lys Leu Ala Gln 215 220
225gcc aaa gaa gag aac gtg ggc tta cat cag aca ctg gat cag aca cta
776Ala Lys Glu Glu Asn Val Gly Leu His Gln Thr Leu Asp Gln Thr Leu
230 235 240aac gaa ctt aac tgt ata
taa gcaaaacaga agagtcttgt tccaacagaa 827Asn Glu Leu Asn Cys Ile
245actctggagc tccgtgggtc tttctcttct cttgtaagaa gttccttttg ttattgccat
887cttcgctttg ctggaaatgt caagcaaatt atgaatacat gaccaaatat tttgtatcgg
947agaagctttg agcaccagtt aaatctcatt ccttcccttt ttttttcaaa tggcaccagc
1007tttttcagct ctcttatttt ttccttaagt agcatttatt cctaaggtag gcagggtatt
1067tcctagtaag catactttct taagacggag gccatttggt tcctgggaga ataggcagcc
1127ccacactttg aagaatacag accccagtat ctagtcgtgg atataattaa aacgctgaag
1187accataacct tttgggtcaa ctgttggtca aactatagga gagaccaggg accatcacat
1247gggtagggat tttccatcca gagccaataa aaggactggt gggggccggg ggtggctatt
1307gtgggaagtc ataacccaca gatagatcaa cctaagaatc ctggcccttc tccactctcc
1367accatgcagg acaaacatct tctcaagcag tcaacgtaga atgcttggga aatagtcata
1427attacccaca tatagtaatt aatagatggt aattaattga tccttgatgt gatgttcttt
1487tgcatatttc cttcattcta aagttgttcc ctggccggga gcgtttgctt tcgcctgtaa
1547tcccaacact ttgggaggcc aggacagatc acttgaggtc aggagttcga gaccagccca
1607gccaacatgg cgaaaccatg tctctactaa aaatacaaaa attatggtga cgcctgcctg
1667tagtcccagc tactcgggag gctgaggcag gaggatcgct tgaacccagg aagtggagac
1727tgcagtgagc cgatatcgca ccacagcgct ccagcctggt cgacagagtg agactccatc
1787tcaagaaaaa ataaaaataa agttgttctc tgaagagcaa atgtctcatt ccagtaatga
1847cccactcagc aggaatatgg tggagttcag tccaattcag gtcagccata tccaaaagac
1907cacaagtcat tactaagttg agcaaaagag tttttatcta ttagcagaaa gggcctctct
1967ggcagcagag attaaaaact ggcccaactt catttccata cttcagggaa cagcaaattg
2027aggatttact tatctaggac tt
20494248PRTHomo sapiens 4Met Ala Gly Leu Asn Ser Leu Glu Ala Val Lys Arg
Lys Ile Gln Ala1 5 10
15Leu Gln Gln Gln Ala Asp Glu Ala Glu Asp Arg Ala Gln Gly Leu Gln
20 25 30Arg Glu Leu Asp Gly Glu Arg
Glu Arg Arg Glu Lys Ala Glu Gly Asp 35 40
45Val Ala Ala Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu
Asp 50 55 60Arg Ala Gln Glu Arg Leu
Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala65 70
75 80Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met
Lys Val Ile Glu Asn 85 90
95Arg Ala Met Lys Asp Glu Glu Lys Met Glu Ile Gln Glu Met Gln Leu
100 105 110Lys Glu Ala Lys His Ile
Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 115 120
125Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu Glu Arg
Ala Glu 130 135 140Glu Arg Ala Glu Val
Ser Glu Leu Lys Cys Gly Asp Leu Glu Glu Glu145 150
155 160Leu Lys Asn Val Thr Asn Asn Leu Lys Ser
Leu Glu Ala Ala Ser Glu 165 170
175Lys Tyr Ser Glu Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Leu Leu
180 185 190Ser Asp Lys Leu Lys
Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 195
200 205Thr Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu
Glu Glu Lys Leu 210 215 220Ala Gln Ala
Lys Glu Glu Asn Val Gly Leu His Gln Thr Leu Asp Gln225
230 235 240Thr Leu Asn Glu Leu Asn Cys
Ile 24552251DNAHomo sapiensCDS(154)..(1533) 5gccgcgtgca
gaggtgctca agcctcctcg cggtccgcag tcagtgccgc cgcgcccggc 60ctcccgcacg
ccccgcaggt agcgcccccg cccgcggccc agagtgcgct cgcgccggca 120ccagctcccg
gataaacggc gcgccgcgcg gag atg aca gcc gag gag atg aag 174
Met Thr Ala Glu Glu Met Lys
1 5gcg acc gag agc ggg gcg cag tcg gcg ccg
ctg ccc atg gag gga gtg 222Ala Thr Glu Ser Gly Ala Gln Ser Ala Pro
Leu Pro Met Glu Gly Val 10 15
20gac atc agc ccc aaa cag gac gaa ggc gtg ctg aag gtc atc aag aga
270Asp Ile Ser Pro Lys Gln Asp Glu Gly Val Leu Lys Val Ile Lys Arg 25
30 35gag ggc aca ggt aca gag atg ccc atg
att ggg gac cga gtc ttt gtc 318Glu Gly Thr Gly Thr Glu Met Pro Met
Ile Gly Asp Arg Val Phe Val40 45 50
55cac tac act ggc tgg cta tta gat ggc aca aag ttt gac tcc
agt ctg 366His Tyr Thr Gly Trp Leu Leu Asp Gly Thr Lys Phe Asp Ser
Ser Leu 60 65 70gat cgc
aag gac aaa ttc tcc ttt gac ctg gga aaa ggg gag gtc atc 414Asp Arg
Lys Asp Lys Phe Ser Phe Asp Leu Gly Lys Gly Glu Val Ile 75
80 85aag gct tgg gac att gcc ata gcc acc
atg aag gtg ggg gag gtg tgc 462Lys Ala Trp Asp Ile Ala Ile Ala Thr
Met Lys Val Gly Glu Val Cys 90 95
100cac atc acc tgc aaa cca gaa tat gcc tac ggt tca gca ggc agt cct
510His Ile Thr Cys Lys Pro Glu Tyr Ala Tyr Gly Ser Ala Gly Ser Pro 105
110 115cca aag att ccc ccc aat gcc acg
ctt gta ttt gag gtg gag ttg ttt 558Pro Lys Ile Pro Pro Asn Ala Thr
Leu Val Phe Glu Val Glu Leu Phe120 125
130 135gag ttt aag gga gaa gat ctg acg gaa gag gaa gat
ggc gga atc att 606Glu Phe Lys Gly Glu Asp Leu Thr Glu Glu Glu Asp
Gly Gly Ile Ile 140 145
150cgc aga ata cag act cgc ggt gaa ggc tat gct aag ccc aat gag ggt
654Arg Arg Ile Gln Thr Arg Gly Glu Gly Tyr Ala Lys Pro Asn Glu Gly
155 160 165gct atc gtg gag gtt gca
ctg gaa ggg tac tac aag gac aag ctc ttt 702Ala Ile Val Glu Val Ala
Leu Glu Gly Tyr Tyr Lys Asp Lys Leu Phe 170 175
180gac cag cgg gag ctc cgc ttt gag att ggc gag ggg gag aac
ctg gat 750Asp Gln Arg Glu Leu Arg Phe Glu Ile Gly Glu Gly Glu Asn
Leu Asp 185 190 195ctg cct tat ggt ctg
gag agg gcc att cag cgc atg gag aaa gga gaa 798Leu Pro Tyr Gly Leu
Glu Arg Ala Ile Gln Arg Met Glu Lys Gly Glu200 205
210 215cat tcc atc gtg tac ctc aag ccc agc tat
gct ttt ggc agt gtt ggg 846His Ser Ile Val Tyr Leu Lys Pro Ser Tyr
Ala Phe Gly Ser Val Gly 220 225
230aag gaa aag ttc caa atc cca cca aat gct gag ctg aaa tat gaa tta
894Lys Glu Lys Phe Gln Ile Pro Pro Asn Ala Glu Leu Lys Tyr Glu Leu
235 240 245cac ctc aag agt ttt gaa
aag gcc aag gag tct tgg gag atg aat tca 942His Leu Lys Ser Phe Glu
Lys Ala Lys Glu Ser Trp Glu Met Asn Ser 250 255
260gaa gag aag ctg gaa cag agc acc ata gtg aaa gag cgg ggc
act gtg 990Glu Glu Lys Leu Glu Gln Ser Thr Ile Val Lys Glu Arg Gly
Thr Val 265 270 275tac ttc aag gaa ggt
aaa tac aag caa gct tta cta cag tat aag aag 1038Tyr Phe Lys Glu Gly
Lys Tyr Lys Gln Ala Leu Leu Gln Tyr Lys Lys280 285
290 295atc gtg tct tgg ctg gaa tat gag tct agt
ttt tcc aat gag gaa gca 1086Ile Val Ser Trp Leu Glu Tyr Glu Ser Ser
Phe Ser Asn Glu Glu Ala 300 305
310cag aaa gca cag gcc ctt cga ctg gcc tct cac ctc aac ctg gcc atg
1134Gln Lys Ala Gln Ala Leu Arg Leu Ala Ser His Leu Asn Leu Ala Met
315 320 325tgt cat ctg aaa cta cag
gcc ttc tct gct gcc att gaa agc tgt aac 1182Cys His Leu Lys Leu Gln
Ala Phe Ser Ala Ala Ile Glu Ser Cys Asn 330 335
340aag gcc cta gaa ctg gac agc aac aac gag aag ggc ctc ttc
cgc cgg 1230Lys Ala Leu Glu Leu Asp Ser Asn Asn Glu Lys Gly Leu Phe
Arg Arg 345 350 355gga gag gcc cac ctg
gcc gtg aat gac ttt gaa ctg gca cgg gct gat 1278Gly Glu Ala His Leu
Ala Val Asn Asp Phe Glu Leu Ala Arg Ala Asp360 365
370 375ttc cag aag gtc ctg cag ctc tac ccc aac
aac aaa gcc gcc aag acc 1326Phe Gln Lys Val Leu Gln Leu Tyr Pro Asn
Asn Lys Ala Ala Lys Thr 380 385
390cag ctg gct gtg tgc cag cag cgg atc cga agg cag ctt gcc cgg gag
1374Gln Leu Ala Val Cys Gln Gln Arg Ile Arg Arg Gln Leu Ala Arg Glu
395 400 405aag aag ctc tat gcc aat
atg ttt gag agg ctg gct gag gag gag aac 1422Lys Lys Leu Tyr Ala Asn
Met Phe Glu Arg Leu Ala Glu Glu Glu Asn 410 415
420aag gcc aag gca gag gct tcc tca gga gac cat ccc act gac
aca gag 1470Lys Ala Lys Ala Glu Ala Ser Ser Gly Asp His Pro Thr Asp
Thr Glu 425 430 435atg aag gag gag cag
aag agc aac acg gca ggg agc cag tct cag gtg 1518Met Lys Glu Glu Gln
Lys Ser Asn Thr Ala Gly Ser Gln Ser Gln Val440 445
450 455gag aca gaa gca tag cccctctcca ccagccctac
tcctgcggct gcctgccccc 1573Glu Thr Glu Alacagtctcccc actccaccct
gttagttttg taaaaactga agaattttga gtgaattaga 1633cctttatttt tctatctggt
tggatggtgg ctttagggga agggggaaag gtgtaggctg 1693ggggattgag gtggggaatc
attttagctg gtgtcagccc ctcttccctt cctccattgc 1753acatgaacat atgtccatcc
atatatattc atcagaatgt taatttattt tgctccctct 1813gttaggtcca ttttctaagg
gtagaagagg caagtggtag ggatgaggtc tgataagaac 1873ccagggtgga gagggagact
cctgggcagc cgttttcctc atcctttccc tctcccagtc 1933catttccaaa tgtggcctcc
atgtgggtgc tagggacatg ggaaaaacca ctgctatgcc 1993atttcttctc tctgttccct
tcctcacccc cgacggtgtg gctgatgatg tcttctggtg 2053tcatggtgac caccccctgt
tccctgttct ggtatttccc ctgtcagttt cccctctcgg 2113ccaggttgtg tcccaaaatc
ccctcagcct cttctctgca cgttgctgaa ggtccaggct 2173tgcctcaagt tccatgcttg
agcaataaag tggaaacaat aaaacctggg tgtcagacaa 2233aaaaaaaaaa aaaaaaaa
22516459PRTHomo sapiens 6Met
Thr Ala Glu Glu Met Lys Ala Thr Glu Ser Gly Ala Gln Ser Ala1
5 10 15Pro Leu Pro Met Glu Gly Val
Asp Ile Ser Pro Lys Gln Asp Glu Gly 20 25
30Val Leu Lys Val Ile Lys Arg Glu Gly Thr Gly Thr Glu Met
Pro Met 35 40 45Ile Gly Asp Arg
Val Phe Val His Tyr Thr Gly Trp Leu Leu Asp Gly 50 55
60Thr Lys Phe Asp Ser Ser Leu Asp Arg Lys Asp Lys Phe
Ser Phe Asp65 70 75
80Leu Gly Lys Gly Glu Val Ile Lys Ala Trp Asp Ile Ala Ile Ala Thr
85 90 95Met Lys Val Gly Glu Val
Cys His Ile Thr Cys Lys Pro Glu Tyr Ala 100
105 110Tyr Gly Ser Ala Gly Ser Pro Pro Lys Ile Pro Pro
Asn Ala Thr Leu 115 120 125Val Phe
Glu Val Glu Leu Phe Glu Phe Lys Gly Glu Asp Leu Thr Glu 130
135 140Glu Glu Asp Gly Gly Ile Ile Arg Arg Ile Gln
Thr Arg Gly Glu Gly145 150 155
160Tyr Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly
165 170 175Tyr Tyr Lys Asp
Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile 180
185 190Gly Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly
Leu Glu Arg Ala Ile 195 200 205Gln
Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser 210
215 220Tyr Ala Phe Gly Ser Val Gly Lys Glu Lys
Phe Gln Ile Pro Pro Asn225 230 235
240Ala Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala
Lys 245 250 255Glu Ser Trp
Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile 260
265 270Val Lys Glu Arg Gly Thr Val Tyr Phe Lys
Glu Gly Lys Tyr Lys Gln 275 280
285Ala Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser 290
295 300Ser Phe Ser Asn Glu Glu Ala Gln
Lys Ala Gln Ala Leu Arg Leu Ala305 310
315 320Ser His Leu Asn Leu Ala Met Cys His Leu Lys Leu
Gln Ala Phe Ser 325 330
335Ala Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn
340 345 350Glu Lys Gly Leu Phe Arg
Arg Gly Glu Ala His Leu Ala Val Asn Asp 355 360
365Phe Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu
Tyr Pro 370 375 380Asn Asn Lys Ala Ala
Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile385 390
395 400Arg Arg Gln Leu Ala Arg Glu Lys Lys Leu
Tyr Ala Asn Met Phe Glu 405 410
415Arg Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly
420 425 430Asp His Pro Thr Asp
Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr 435
440 445Ala Gly Ser Gln Ser Gln Val Glu Thr Glu Ala 450
45572562DNAHomo sapiensCDS(56)..(1651) 7gccgcgccgg
ctctgggcac tcagcatcgt ttccttttcc tccgctggag cagct atg 58
Met
1gcg gcg gtg aag acc ctg aac ccc
aag gcc gag gtg gcc cga gcg cag 106Ala Ala Val Lys Thr Leu Asn Pro
Lys Ala Glu Val Ala Arg Ala Gln 5 10
15gcg gcg ctg gcg gtc aac atc agc gca gcg cgg ggt ctg cag gac
gtg 154Ala Ala Leu Ala Val Asn Ile Ser Ala Ala Arg Gly Leu Gln Asp
Val 20 25 30cta agg acc aac ctg
ggg ccc aag ggc acc atg aag atg ctc gtt tct 202Leu Arg Thr Asn Leu
Gly Pro Lys Gly Thr Met Lys Met Leu Val Ser 35 40
45ggc gct gga gac atc aaa ctt act aaa gac ggc aat gtg ctg
ctt cac 250Gly Ala Gly Asp Ile Lys Leu Thr Lys Asp Gly Asn Val Leu
Leu His50 55 60 65gaa
atg caa att caa cac cca aca gct tcc tta ata gca aag gta gca 298Glu
Met Gln Ile Gln His Pro Thr Ala Ser Leu Ile Ala Lys Val Ala
70 75 80aca gcc cag gat gat ata act
ggt gat ggt acg act tct aat gtc cta 346Thr Ala Gln Asp Asp Ile Thr
Gly Asp Gly Thr Thr Ser Asn Val Leu 85 90
95atc att gga gag ctg ctg aaa cag gcg gat ctc tac att tct
gaa ggc 394Ile Ile Gly Glu Leu Leu Lys Gln Ala Asp Leu Tyr Ile Ser
Glu Gly 100 105 110ctt cat cct aga
ata atc act gaa gga ttt gaa gct gca aag gaa aag 442Leu His Pro Arg
Ile Ile Thr Glu Gly Phe Glu Ala Ala Lys Glu Lys 115
120 125gcc ctt cag ttt ttg gaa gaa gtc aaa gta agc aga
gag atg gac agg 490Ala Leu Gln Phe Leu Glu Glu Val Lys Val Ser Arg
Glu Met Asp Arg130 135 140
145gaa aca ctt ata gat gtg gcc aga aca tct ctt cgt act aaa gtt cat
538Glu Thr Leu Ile Asp Val Ala Arg Thr Ser Leu Arg Thr Lys Val His
150 155 160gct gaa ctt gca gat
gtc tta aca gag gct gta gtg gac tcc att ttg 586Ala Glu Leu Ala Asp
Val Leu Thr Glu Ala Val Val Asp Ser Ile Leu 165
170 175gcc att aaa aag caa gat gaa cct att gat ctc ttc
atg att gag atc 634Ala Ile Lys Lys Gln Asp Glu Pro Ile Asp Leu Phe
Met Ile Glu Ile 180 185 190atg gag
atg aaa cat aaa tct gaa act gat aca agc tta atc aga ggg 682Met Glu
Met Lys His Lys Ser Glu Thr Asp Thr Ser Leu Ile Arg Gly 195
200 205ctt gtt ttg gac cac gga gca cgg cat cct gat
atg aag aaa agg gtg 730Leu Val Leu Asp His Gly Ala Arg His Pro Asp
Met Lys Lys Arg Val210 215 220
225gag gat gca tac atc ctc act tgt aac gtg tca tta gag tat gag aaa
778Glu Asp Ala Tyr Ile Leu Thr Cys Asn Val Ser Leu Glu Tyr Glu Lys
230 235 240aca gaa gtg aat tct
ggc ttt ttt tac aag agt gca gaa gag aga gaa 826Thr Glu Val Asn Ser
Gly Phe Phe Tyr Lys Ser Ala Glu Glu Arg Glu 245
250 255aaa ctc gtg aaa gct gaa aga aaa ttc att gaa gat
agg gtt aaa aaa 874Lys Leu Val Lys Ala Glu Arg Lys Phe Ile Glu Asp
Arg Val Lys Lys 260 265 270ata ata
gaa ctg aaa agg aaa gtc tgt ggc gat tca gat aaa gga ttt 922Ile Ile
Glu Leu Lys Arg Lys Val Cys Gly Asp Ser Asp Lys Gly Phe 275
280 285gtt gtt att aat caa aag gga att gac ccc ttt
tcc tta gat gct ctt 970Val Val Ile Asn Gln Lys Gly Ile Asp Pro Phe
Ser Leu Asp Ala Leu290 295 300
305tca aaa gaa ggc ata gtc gct ctg cgc aga gct aaa agg aga aat atg
1018Ser Lys Glu Gly Ile Val Ala Leu Arg Arg Ala Lys Arg Arg Asn Met
310 315 320gag agg ctg act ctt
gct tgt ggt ggg gta gcc ctg aat tct ttt gac 1066Glu Arg Leu Thr Leu
Ala Cys Gly Gly Val Ala Leu Asn Ser Phe Asp 325
330 335gac cta agt cct gac tgc ttg gga cat gca gga ctt
gta tat gag tat 1114Asp Leu Ser Pro Asp Cys Leu Gly His Ala Gly Leu
Val Tyr Glu Tyr 340 345 350aca ttg
gga gaa gag aag ttt acc ttt att gag aaa tgt aac aac cct 1162Thr Leu
Gly Glu Glu Lys Phe Thr Phe Ile Glu Lys Cys Asn Asn Pro 355
360 365cgt tct gtc aca tta ttg atc aaa gga cca aat
aag cac aca ctc act 1210Arg Ser Val Thr Leu Leu Ile Lys Gly Pro Asn
Lys His Thr Leu Thr370 375 380
385cag atc aaa gat gca gtg agg gac ggc ttg agg gct gtc aaa aat gct
1258Gln Ile Lys Asp Ala Val Arg Asp Gly Leu Arg Ala Val Lys Asn Ala
390 395 400att gat gat ggc tgt
gtg gtt cca ggt gct ggt gcc gtg gaa gtg gca 1306Ile Asp Asp Gly Cys
Val Val Pro Gly Ala Gly Ala Val Glu Val Ala 405
410 415atg gca gaa gcc ctg att aaa cat aag ccc agt gta
aag ggc agg gca 1354Met Ala Glu Ala Leu Ile Lys His Lys Pro Ser Val
Lys Gly Arg Ala 420 425 430cag ctt
gga gtc caa gca ttt gct gat gca ttg ctc att att ccc aag 1402Gln Leu
Gly Val Gln Ala Phe Ala Asp Ala Leu Leu Ile Ile Pro Lys 435
440 445gtt ctt gct cag aac tct ggt ttt gac ctt cag
gaa aca tta gtt aaa 1450Val Leu Ala Gln Asn Ser Gly Phe Asp Leu Gln
Glu Thr Leu Val Lys450 455 460
465att caa gca gaa cat tca gaa tca ggt cag ctt gtg ggt gtg gac ctg
1498Ile Gln Ala Glu His Ser Glu Ser Gly Gln Leu Val Gly Val Asp Leu
470 475 480aac aca ggt gag cca
atg gtg gca gca gaa gta ggc gta tgg gat aac 1546Asn Thr Gly Glu Pro
Met Val Ala Ala Glu Val Gly Val Trp Asp Asn 485
490 495tat tgt gta aag aaa cag ctt ctt cac tcc tgc act
gtg att gcc acc 1594Tyr Cys Val Lys Lys Gln Leu Leu His Ser Cys Thr
Val Ile Ala Thr 500 505 510aac att
ctc ttg gtt gat gag atc atg cga gct gga atg tct tct ctg 1642Asn Ile
Leu Leu Val Asp Glu Ile Met Arg Ala Gly Met Ser Ser Leu 515
520 525aaa ggt tga attgaagctt cctctgtatc tgaatcttga
agactgcaaa 1691Lys Gly530gtgatcctga ggattacagc tgtggaattt
ttgtccaagc ttcaaataat tttgaaagaa 1751attttcccat atgaaaaaag gagagaacac
tggcatctgt tgaaatttgg aagttctgaa 1811attatagtat ttttaaaaat tgcactgaag
tgtatacaca taaagcaggt cttttatcca 1871gtgaacagga tgttttgctt tagcagcagt
gacataaaat tccatgttag ataagcatat 1931gttacttacc ttgttattaa atatttcttg
aaaagcaaat tttaatggtt aattttatgt 1991ggacgtatgt taaattatcc aaactaccct
attgttaagc atttggtttt aaaattttta 2051tgctaatata aatgctcaag taatttaaaa
tattgaaagc atccctgttg gtataaattt 2111ctgagtaaat gcattggatc agttggactt
tgaacgccct ttgaaatggc tttgctaaaa 2171tgctcccgcc acaaagttgt aggaaatggg
aagaggagtc aactagaggc aagggagttg 2231agagagctgc aactgtaaag ggcaagaaca
ggcagaggta aaaagatgat ggaaggtgtg 2291gtgactaagg gccacggtta ttgggtgaaa
tttgagatgt aggccaactg tattttcaag 2351cttctgaact taaggcaaaa tattcatcgc
aaagtctcta gcgtcatatt tttctcaccc 2411aaattacgtt tccacgagtt attatatata
gttggtctat ctctgcagtc cttgaaggtg 2471aagttgtgtg ttactaggct gtgttttggg
atgtcagcag tggcctgaag tgagttgtgc 2531aataaatgtt aagttgaaac ctcaaaaaaa a
25628531PRTHomo sapiens 8Met Ala Ala Val
Lys Thr Leu Asn Pro Lys Ala Glu Val Ala Arg Ala1 5
10 15Gln Ala Ala Leu Ala Val Asn Ile Ser Ala
Ala Arg Gly Leu Gln Asp 20 25
30Val Leu Arg Thr Asn Leu Gly Pro Lys Gly Thr Met Lys Met Leu Val
35 40 45Ser Gly Ala Gly Asp Ile Lys Leu
Thr Lys Asp Gly Asn Val Leu Leu 50 55
60His Glu Met Gln Ile Gln His Pro Thr Ala Ser Leu Ile Ala Lys Val65
70 75 80Ala Thr Ala Gln Asp
Asp Ile Thr Gly Asp Gly Thr Thr Ser Asn Val 85
90 95Leu Ile Ile Gly Glu Leu Leu Lys Gln Ala Asp
Leu Tyr Ile Ser Glu 100 105
110Gly Leu His Pro Arg Ile Ile Thr Glu Gly Phe Glu Ala Ala Lys Glu
115 120 125Lys Ala Leu Gln Phe Leu Glu
Glu Val Lys Val Ser Arg Glu Met Asp 130 135
140Arg Glu Thr Leu Ile Asp Val Ala Arg Thr Ser Leu Arg Thr Lys
Val145 150 155 160His Ala
Glu Leu Ala Asp Val Leu Thr Glu Ala Val Val Asp Ser Ile
165 170 175Leu Ala Ile Lys Lys Gln Asp
Glu Pro Ile Asp Leu Phe Met Ile Glu 180 185
190Ile Met Glu Met Lys His Lys Ser Glu Thr Asp Thr Ser Leu
Ile Arg 195 200 205Gly Leu Val Leu
Asp His Gly Ala Arg His Pro Asp Met Lys Lys Arg 210
215 220Val Glu Asp Ala Tyr Ile Leu Thr Cys Asn Val Ser
Leu Glu Tyr Glu225 230 235
240Lys Thr Glu Val Asn Ser Gly Phe Phe Tyr Lys Ser Ala Glu Glu Arg
245 250 255Glu Lys Leu Val Lys
Ala Glu Arg Lys Phe Ile Glu Asp Arg Val Lys 260
265 270Lys Ile Ile Glu Leu Lys Arg Lys Val Cys Gly Asp
Ser Asp Lys Gly 275 280 285Phe Val
Val Ile Asn Gln Lys Gly Ile Asp Pro Phe Ser Leu Asp Ala 290
295 300Leu Ser Lys Glu Gly Ile Val Ala Leu Arg Arg
Ala Lys Arg Arg Asn305 310 315
320Met Glu Arg Leu Thr Leu Ala Cys Gly Gly Val Ala Leu Asn Ser Phe
325 330 335Asp Asp Leu Ser
Pro Asp Cys Leu Gly His Ala Gly Leu Val Tyr Glu 340
345 350Tyr Thr Leu Gly Glu Glu Lys Phe Thr Phe Ile
Glu Lys Cys Asn Asn 355 360 365Pro
Arg Ser Val Thr Leu Leu Ile Lys Gly Pro Asn Lys His Thr Leu 370
375 380Thr Gln Ile Lys Asp Ala Val Arg Asp Gly
Leu Arg Ala Val Lys Asn385 390 395
400Ala Ile Asp Asp Gly Cys Val Val Pro Gly Ala Gly Ala Val Glu
Val 405 410 415Ala Met Ala
Glu Ala Leu Ile Lys His Lys Pro Ser Val Lys Gly Arg 420
425 430Ala Gln Leu Gly Val Gln Ala Phe Ala Asp
Ala Leu Leu Ile Ile Pro 435 440
445Lys Val Leu Ala Gln Asn Ser Gly Phe Asp Leu Gln Glu Thr Leu Val 450
455 460Lys Ile Gln Ala Glu His Ser Glu
Ser Gly Gln Leu Val Gly Val Asp465 470
475 480Leu Asn Thr Gly Glu Pro Met Val Ala Ala Glu Val
Gly Val Trp Asp 485 490
495Asn Tyr Cys Val Lys Lys Gln Leu Leu His Ser Cys Thr Val Ile Ala
500 505 510Thr Asn Ile Leu Leu Val
Asp Glu Ile Met Arg Ala Gly Met Ser Ser 515 520
525Leu Lys Gly 53092208DNAHomo sapiensCDS(230)..(1486)
9tctttggctt tttttggcgg agctggggcg ccctccggaa gcgtttccaa ctttccagaa
60gtttctcggg acgggcagga gggggtgggg actgccatat atagatcccg ggagcagggg
120agcgggctaa gagtagaatc gtgtcgcggc tcgagagcga gagtcacgtc ccggcgctag
180cccagcccga cccaggccca ccgtggtgca cgcaaaccac ttcctggcc atg cgc tcc
238 Met Arg Ser
1ctc ctg ctt ctc agc gcc
ttc tgc ctc ctg gag gcg gcc ctg gcc gcc 286Leu Leu Leu Leu Ser Ala
Phe Cys Leu Leu Glu Ala Ala Leu Ala Ala 5 10
15gag gtg aag aaa cct gca gcc gca gca gct cct ggc act gcg gag
aag 334Glu Val Lys Lys Pro Ala Ala Ala Ala Ala Pro Gly Thr Ala Glu
Lys20 25 30 35ttg agc
ccc aag gcg gcc acg ctt gcc gag cgc agc gcc ggc ctg gcc 382Leu Ser
Pro Lys Ala Ala Thr Leu Ala Glu Arg Ser Ala Gly Leu Ala 40
45 50ttc agc ttg tac cag gcc atg gcc
aag gac cag gca gtg gag aac atc 430Phe Ser Leu Tyr Gln Ala Met Ala
Lys Asp Gln Ala Val Glu Asn Ile 55 60
65ctg gtg tca ccc gtg gtg gtg gcc tcg tcg cta ggg ctc gtg tcg
ctg 478Leu Val Ser Pro Val Val Val Ala Ser Ser Leu Gly Leu Val Ser
Leu 70 75 80ggc ggc aag gcg acc
acg gcg tcg cag gcc aag gca gtg ctg agc gcc 526Gly Gly Lys Ala Thr
Thr Ala Ser Gln Ala Lys Ala Val Leu Ser Ala 85 90
95gag cag ctg cgc gac gag gag gtg cac gcc ggc ctg ggc gag
ctg ctg 574Glu Gln Leu Arg Asp Glu Glu Val His Ala Gly Leu Gly Glu
Leu Leu100 105 110 115cgc
tca ctc agc aac tcc acg gcg cgc aac gtg acc tgg aag ctg ggc 622Arg
Ser Leu Ser Asn Ser Thr Ala Arg Asn Val Thr Trp Lys Leu Gly
120 125 130agc cga ctg tac gga ccc agc
tca gtg agc ttc gct gat gac ttc gtg 670Ser Arg Leu Tyr Gly Pro Ser
Ser Val Ser Phe Ala Asp Asp Phe Val 135 140
145cgc agc agc aag cag cac tac aac tgc gag cac tcc aag atc
aac ttc 718Arg Ser Ser Lys Gln His Tyr Asn Cys Glu His Ser Lys Ile
Asn Phe 150 155 160cgc gac aag cgc
agc gcg ctg cag tcc atc aac gag tgg gcc gcg cag 766Arg Asp Lys Arg
Ser Ala Leu Gln Ser Ile Asn Glu Trp Ala Ala Gln 165
170 175acc acc gac ggc aag ctg ccc gag gtc acc aag gac
gtg gag cgc acg 814Thr Thr Asp Gly Lys Leu Pro Glu Val Thr Lys Asp
Val Glu Arg Thr180 185 190
195gac ggc gcc ctg cta gtc aac gcc atg ttc ttc aag cca cac tgg gat
862Asp Gly Ala Leu Leu Val Asn Ala Met Phe Phe Lys Pro His Trp Asp
200 205 210gag aaa ttc cac cac
aag atg gtg gac aac cgt ggc ttc atg gtg act 910Glu Lys Phe His His
Lys Met Val Asp Asn Arg Gly Phe Met Val Thr 215
220 225cgg tcc tat acc gtg ggt gtc atg atg atg cac cgg
aca ggc ctc tac 958Arg Ser Tyr Thr Val Gly Val Met Met Met His Arg
Thr Gly Leu Tyr 230 235 240aac tac
tac gac gac gag aag gaa aag ctg caa atc gtg gag atg ccc 1006Asn Tyr
Tyr Asp Asp Glu Lys Glu Lys Leu Gln Ile Val Glu Met Pro 245
250 255ctg gcc cac aag ctc tcc agc ctc atc atc ctc
atg ccc cat cac gtg 1054Leu Ala His Lys Leu Ser Ser Leu Ile Ile Leu
Met Pro His His Val260 265 270
275gag cct ctc gag cgc ctt gaa aag ctg cta acc aaa gag cag ctg aag
1102Glu Pro Leu Glu Arg Leu Glu Lys Leu Leu Thr Lys Glu Gln Leu Lys
280 285 290atc tgg atg ggg aag
atg cag aag aag gct gtt gcc atc tcc ttg ccc 1150Ile Trp Met Gly Lys
Met Gln Lys Lys Ala Val Ala Ile Ser Leu Pro 295
300 305aag ggt gtg gtg gag gtg acc cat gac ctg cag aaa
cac ctg gct ggg 1198Lys Gly Val Val Glu Val Thr His Asp Leu Gln Lys
His Leu Ala Gly 310 315 320ctg ggc
ctg act gag gcc att gac aag aac aag gcc gac ttg tca cgc 1246Leu Gly
Leu Thr Glu Ala Ile Asp Lys Asn Lys Ala Asp Leu Ser Arg 325
330 335atg tca ggc aag aag gac ctg tac ctg gcc agc
gtg ttc cac gcc acc 1294Met Ser Gly Lys Lys Asp Leu Tyr Leu Ala Ser
Val Phe His Ala Thr340 345 350
355gcc ttt gag ttg gac aca gat ggc aac ccc ttt gac cag gac atc tac
1342Ala Phe Glu Leu Asp Thr Asp Gly Asn Pro Phe Asp Gln Asp Ile Tyr
360 365 370ggg cgc gag gag ctg
cgc agc ccc aag ctg ttc tac gcc gac cac ccc 1390Gly Arg Glu Glu Leu
Arg Ser Pro Lys Leu Phe Tyr Ala Asp His Pro 375
380 385ttc atc ttc cta gtg cgg gac acc caa agc ggc tcc
ctg cta ttc att 1438Phe Ile Phe Leu Val Arg Asp Thr Gln Ser Gly Ser
Leu Leu Phe Ile 390 395 400ggg cgc
ctg gtc cgg cct aag ggt gac aag atg cga gac gag tta tag 1486Gly Arg
Leu Val Arg Pro Lys Gly Asp Lys Met Arg Asp Glu Leu 405
410 415ggcctcaggg tgcacacagg atggcaggag gcatccaaag
gctcctgaga cacatgggtg 1546ctattggggt tgggggggag gtgaggtacc agccttggat
actccatggg gtgggggtgg 1606aaaaacagac cggggttccc gtgtgcctga gcggaccttc
ccagctagaa ttcactccac 1666ttggacatgg gccccagata ccatgatgct gagcccggaa
actccacatc ctgtgggacc 1726tgggccatag tcattctgcc tgccctgaaa gtcccagatc
aagcctgcct caatcagtat 1786tcatatttat agccaggtac cttctcacct gtgagaccaa
attgagctag gggggtcagc 1846cagccctctt ctgacactaa aacacctcag ctgcctcccc
agctctatcc caacctctcc 1906caactataaa actaggtgct gcagcccctg ggaccaggca
cccccagaat gacctggccg 1966cagtgaggcg gattgagaag gagctcccag gaggggcttc
tgggcagact ctggtcaaga 2026agcatcgtgt ctggcgttgt ggggatgaac tttttgtttt
gtttcttcct tttttagttc 2086ttcaaagata gggagggaag ggggaacatg agcctttgtt
gctatcaatc caagaactta 2146tttgtacatt ttttttttca ataaaacttt tccaatgaca
ttttgttgga gcgtggaaaa 2206aa
220810418PRTHomo sapiens 10Met Arg Ser Leu Leu Leu
Leu Ser Ala Phe Cys Leu Leu Glu Ala Ala1 5
10 15Leu Ala Ala Glu Val Lys Lys Pro Ala Ala Ala Ala
Ala Pro Gly Thr 20 25 30Ala
Glu Lys Leu Ser Pro Lys Ala Ala Thr Leu Ala Glu Arg Ser Ala 35
40 45Gly Leu Ala Phe Ser Leu Tyr Gln Ala
Met Ala Lys Asp Gln Ala Val 50 55
60Glu Asn Ile Leu Val Ser Pro Val Val Val Ala Ser Ser Leu Gly Leu65
70 75 80Val Ser Leu Gly Gly
Lys Ala Thr Thr Ala Ser Gln Ala Lys Ala Val 85
90 95Leu Ser Ala Glu Gln Leu Arg Asp Glu Glu Val
His Ala Gly Leu Gly 100 105
110Glu Leu Leu Arg Ser Leu Ser Asn Ser Thr Ala Arg Asn Val Thr Trp
115 120 125Lys Leu Gly Ser Arg Leu Tyr
Gly Pro Ser Ser Val Ser Phe Ala Asp 130 135
140Asp Phe Val Arg Ser Ser Lys Gln His Tyr Asn Cys Glu His Ser
Lys145 150 155 160Ile Asn
Phe Arg Asp Lys Arg Ser Ala Leu Gln Ser Ile Asn Glu Trp
165 170 175Ala Ala Gln Thr Thr Asp Gly
Lys Leu Pro Glu Val Thr Lys Asp Val 180 185
190Glu Arg Thr Asp Gly Ala Leu Leu Val Asn Ala Met Phe Phe
Lys Pro 195 200 205His Trp Asp Glu
Lys Phe His His Lys Met Val Asp Asn Arg Gly Phe 210
215 220Met Val Thr Arg Ser Tyr Thr Val Gly Val Met Met
Met His Arg Thr225 230 235
240Gly Leu Tyr Asn Tyr Tyr Asp Asp Glu Lys Glu Lys Leu Gln Ile Val
245 250 255Glu Met Pro Leu Ala
His Lys Leu Ser Ser Leu Ile Ile Leu Met Pro 260
265 270His His Val Glu Pro Leu Glu Arg Leu Glu Lys Leu
Leu Thr Lys Glu 275 280 285Gln Leu
Lys Ile Trp Met Gly Lys Met Gln Lys Lys Ala Val Ala Ile 290
295 300Ser Leu Pro Lys Gly Val Val Glu Val Thr His
Asp Leu Gln Lys His305 310 315
320Leu Ala Gly Leu Gly Leu Thr Glu Ala Ile Asp Lys Asn Lys Ala Asp
325 330 335Leu Ser Arg Met
Ser Gly Lys Lys Asp Leu Tyr Leu Ala Ser Val Phe 340
345 350His Ala Thr Ala Phe Glu Leu Asp Thr Asp Gly
Asn Pro Phe Asp Gln 355 360 365Asp
Ile Tyr Gly Arg Glu Glu Leu Arg Ser Pro Lys Leu Phe Tyr Ala 370
375 380Asp His Pro Phe Ile Phe Leu Val Arg Asp
Thr Gln Ser Gly Ser Leu385 390 395
400Leu Phe Ile Gly Arg Leu Val Arg Pro Lys Gly Asp Lys Met Arg
Asp 405 410 415Glu
Leu111690DNAHomo sapiensCDS(77)..(1429) 11ggcacgagga aggtttttgc
tgcgccaacg cagtgaccga aggctccgct cacgcccggc 60ctgatcctgc ctgaag atg
gtg cca ctg gtg gct gtg gta tca ggg ccc cgt 112 Met
Val Pro Leu Val Ala Val Val Ser Gly Pro Arg 1
5 10gcc cag ctc ttt gcc tgc ctg ctc agg ctg ggc act
cag cag gtc ggc 160Ala Gln Leu Phe Ala Cys Leu Leu Arg Leu Gly Thr
Gln Gln Val Gly 15 20 25ccc ctt
cag ctg cac acc ggg gcc agc cat gcg gcc agg aac cat tat 208Pro Leu
Gln Leu His Thr Gly Ala Ser His Ala Ala Arg Asn His Tyr 30
35 40gag gtg ctg gtg ctg ggt ggg ggc agt ggc gga
atc acc atg gct gcc 256Glu Val Leu Val Leu Gly Gly Gly Ser Gly Gly
Ile Thr Met Ala Ala45 50 55
60cgc atg aag agg aaa gtg ggt gca gag aat gtg gcc att gtt gag ccc
304Arg Met Lys Arg Lys Val Gly Ala Glu Asn Val Ala Ile Val Glu Pro
65 70 75agt gag aga cat ttc
tac cag cca atc tgg aca ctg gtg ggt gct ggt 352Ser Glu Arg His Phe
Tyr Gln Pro Ile Trp Thr Leu Val Gly Ala Gly 80
85 90gcc aaa caa ttg tcc tca tct ggt cgt ccc acg gca
agt gtg att cca 400Ala Lys Gln Leu Ser Ser Ser Gly Arg Pro Thr Ala
Ser Val Ile Pro 95 100 105tct ggt
gta gaa tgg atc aaa gct aga gtg act gag ttg aac cca gac 448Ser Gly
Val Glu Trp Ile Lys Ala Arg Val Thr Glu Leu Asn Pro Asp 110
115 120aag aac tgc att cac aca gat gac gac gag aag
atc tcc tac cga tat 496Lys Asn Cys Ile His Thr Asp Asp Asp Glu Lys
Ile Ser Tyr Arg Tyr125 130 135
140ctt att att gct ctc gga atc cag ctg gac tat gag aag att aaa ggc
544Leu Ile Ile Ala Leu Gly Ile Gln Leu Asp Tyr Glu Lys Ile Lys Gly
145 150 155cta cct gaa ggt ttc
gct cat ccc aaa ata ggg tcg aat tat tca gtt 592Leu Pro Glu Gly Phe
Ala His Pro Lys Ile Gly Ser Asn Tyr Ser Val 160
165 170aag act gta gag aag aca tgg aaa gct ctg cag gac
ttc aaa gag ggc 640Lys Thr Val Glu Lys Thr Trp Lys Ala Leu Gln Asp
Phe Lys Glu Gly 175 180 185aat gcc
atc ttc acc ttc cca aat act cca gtg aag tgt gct gga gcc 688Asn Ala
Ile Phe Thr Phe Pro Asn Thr Pro Val Lys Cys Ala Gly Ala 190
195 200cct cag aag atc atg tac tta tca gaa gcc tac
ttc agg aag aca ggg 736Pro Gln Lys Ile Met Tyr Leu Ser Glu Ala Tyr
Phe Arg Lys Thr Gly205 210 215
220aag cga tcc aag gcc aat atc att ttc aac act tct ctt gga gcc att
784Lys Arg Ser Lys Ala Asn Ile Ile Phe Asn Thr Ser Leu Gly Ala Ile
225 230 235ttc ggg gtt aag aag
tat gca gat gcc ctg cag gag atc atc cag gag 832Phe Gly Val Lys Lys
Tyr Ala Asp Ala Leu Gln Glu Ile Ile Gln Glu 240
245 250cgg aac ctc act gtt aac tac aag aaa aac ctc att
gaa gtc cga gcc 880Arg Asn Leu Thr Val Asn Tyr Lys Lys Asn Leu Ile
Glu Val Arg Ala 255 260 265gat aaa
caa gag gct gta ttt gag aac ctg gac aaa cca gga gag acc 928Asp Lys
Gln Glu Ala Val Phe Glu Asn Leu Asp Lys Pro Gly Glu Thr 270
275 280caa gtg att tca tat gaa atg ctt cat gtc aca
cct cca atg agc cca 976Gln Val Ile Ser Tyr Glu Met Leu His Val Thr
Pro Pro Met Ser Pro285 290 295
300cca gat gtc ctc aag acc agt cct gtg gct gat gct gct ggt tgg gtg
1024Pro Asp Val Leu Lys Thr Ser Pro Val Ala Asp Ala Ala Gly Trp Val
305 310 315gat gtg gat aaa gaa
act ctg caa cac agg agg tac cca aat gtg ttt 1072Asp Val Asp Lys Glu
Thr Leu Gln His Arg Arg Tyr Pro Asn Val Phe 320
325 330ggg att ggg gac tgc acc aac ctt cct acg tca aag
acc gct gct gca 1120Gly Ile Gly Asp Cys Thr Asn Leu Pro Thr Ser Lys
Thr Ala Ala Ala 335 340 345gta gct
gcc cag tca gga ata ctt gat agg aca att tct gta att atg 1168Val Ala
Ala Gln Ser Gly Ile Leu Asp Arg Thr Ile Ser Val Ile Met 350
355 360aag aat caa aca cca aca aag aag tat gat ggc
tac aca tca tgt cca 1216Lys Asn Gln Thr Pro Thr Lys Lys Tyr Asp Gly
Tyr Thr Ser Cys Pro365 370 375
380ctg gtg acc ggc tac aac cgt gtg att ctt gct gag ttt gac tac aaa
1264Leu Val Thr Gly Tyr Asn Arg Val Ile Leu Ala Glu Phe Asp Tyr Lys
385 390 395gca gag ccg cta gaa
acc ttc ccc ttt gat caa agc aaa gag cgc ctt 1312Ala Glu Pro Leu Glu
Thr Phe Pro Phe Asp Gln Ser Lys Glu Arg Leu 400
405 410tcc atg tat ctc atg aaa gct gac ctg atg cct ttc
ctg tat tgg aat 1360Ser Met Tyr Leu Met Lys Ala Asp Leu Met Pro Phe
Leu Tyr Trp Asn 415 420 425atg atg
cta agg ggt tac tgg gga gga cca gcg ttt ctg cgc aag ttg 1408Met Met
Leu Arg Gly Tyr Trp Gly Gly Pro Ala Phe Leu Arg Lys Leu 430
435 440ttt cat cta ggt atg agt taa ggatggctca
gcacttgctc atcttggatg 1459Phe His Leu Gly Met Ser445
450gcttctgggc caaaactgca gtcactgaat gaccaagagc agcacgaagg acttggaacc
1519tatccttgta aagagttcct tgatgggtaa tggtgaccaa atgcctccct tttcagtacc
1579tttgaacagc aaccatgtgg gctactcatg atgggcttga ttctttggga ataataaaat
1639gaaataatac ttttattttc tgaataaaag tttgtcactg aaaaaaaaaa a
169012450PRTHomo sapiens 12Met Val Pro Leu Val Ala Val Val Ser Gly Pro
Arg Ala Gln Leu Phe1 5 10
15Ala Cys Leu Leu Arg Leu Gly Thr Gln Gln Val Gly Pro Leu Gln Leu
20 25 30His Thr Gly Ala Ser His Ala
Ala Arg Asn His Tyr Glu Val Leu Val 35 40
45Leu Gly Gly Gly Ser Gly Gly Ile Thr Met Ala Ala Arg Met Lys
Arg 50 55 60Lys Val Gly Ala Glu Asn
Val Ala Ile Val Glu Pro Ser Glu Arg His65 70
75 80Phe Tyr Gln Pro Ile Trp Thr Leu Val Gly Ala
Gly Ala Lys Gln Leu 85 90
95Ser Ser Ser Gly Arg Pro Thr Ala Ser Val Ile Pro Ser Gly Val Glu
100 105 110Trp Ile Lys Ala Arg Val
Thr Glu Leu Asn Pro Asp Lys Asn Cys Ile 115 120
125His Thr Asp Asp Asp Glu Lys Ile Ser Tyr Arg Tyr Leu Ile
Ile Ala 130 135 140Leu Gly Ile Gln Leu
Asp Tyr Glu Lys Ile Lys Gly Leu Pro Glu Gly145 150
155 160Phe Ala His Pro Lys Ile Gly Ser Asn Tyr
Ser Val Lys Thr Val Glu 165 170
175Lys Thr Trp Lys Ala Leu Gln Asp Phe Lys Glu Gly Asn Ala Ile Phe
180 185 190Thr Phe Pro Asn Thr
Pro Val Lys Cys Ala Gly Ala Pro Gln Lys Ile 195
200 205Met Tyr Leu Ser Glu Ala Tyr Phe Arg Lys Thr Gly
Lys Arg Ser Lys 210 215 220Ala Asn Ile
Ile Phe Asn Thr Ser Leu Gly Ala Ile Phe Gly Val Lys225
230 235 240Lys Tyr Ala Asp Ala Leu Gln
Glu Ile Ile Gln Glu Arg Asn Leu Thr 245
250 255Val Asn Tyr Lys Lys Asn Leu Ile Glu Val Arg Ala
Asp Lys Gln Glu 260 265 270Ala
Val Phe Glu Asn Leu Asp Lys Pro Gly Glu Thr Gln Val Ile Ser 275
280 285Tyr Glu Met Leu His Val Thr Pro Pro
Met Ser Pro Pro Asp Val Leu 290 295
300Lys Thr Ser Pro Val Ala Asp Ala Ala Gly Trp Val Asp Val Asp Lys305
310 315 320Glu Thr Leu Gln
His Arg Arg Tyr Pro Asn Val Phe Gly Ile Gly Asp 325
330 335Cys Thr Asn Leu Pro Thr Ser Lys Thr Ala
Ala Ala Val Ala Ala Gln 340 345
350Ser Gly Ile Leu Asp Arg Thr Ile Ser Val Ile Met Lys Asn Gln Thr
355 360 365Pro Thr Lys Lys Tyr Asp Gly
Tyr Thr Ser Cys Pro Leu Val Thr Gly 370 375
380Tyr Asn Arg Val Ile Leu Ala Glu Phe Asp Tyr Lys Ala Glu Pro
Leu385 390 395 400Glu Thr
Phe Pro Phe Asp Gln Ser Lys Glu Arg Leu Ser Met Tyr Leu
405 410 415Met Lys Ala Asp Leu Met Pro
Phe Leu Tyr Trp Asn Met Met Leu Arg 420 425
430Gly Tyr Trp Gly Gly Pro Ala Phe Leu Arg Lys Leu Phe His
Leu Gly 435 440 445Met Ser
450132593DNAHomo sapiensCDS(49)..(2259) 13ggccagcgcg tctgcttgtt
cgtgtgtgtg tcgttgcagg ccttattc atg ggc tca 57
Met Gly Ser
1ccg ctg agg ttc gac ggg cgg gtg gta ctg gtc acc ggc
gcg ggg gca 105Pro Leu Arg Phe Asp Gly Arg Val Val Leu Val Thr Gly
Ala Gly Ala 5 10 15gga ttg ggc cga
gcc tat gcc ctg gct ttt gca gaa aga gga gcg tta 153Gly Leu Gly Arg
Ala Tyr Ala Leu Ala Phe Ala Glu Arg Gly Ala Leu20 25
30 35gtt gtt gtg aat gat ttg gga ggg gac
ttc aaa gga gtt ggt aaa ggc 201Val Val Val Asn Asp Leu Gly Gly Asp
Phe Lys Gly Val Gly Lys Gly 40 45
50tcc tta gct gct gat aag gtt gtt gaa gaa ata aga agg aga ggt
gga 249Ser Leu Ala Ala Asp Lys Val Val Glu Glu Ile Arg Arg Arg Gly
Gly 55 60 65aaa gca gtg gcc
aac tat gat tca gtg gaa gaa gga gag aag gtt gtg 297Lys Ala Val Ala
Asn Tyr Asp Ser Val Glu Glu Gly Glu Lys Val Val 70
75 80aag aca gcc ctg gat gct ttt gga aga ata gat gtt
gtg gtc aac aat 345Lys Thr Ala Leu Asp Ala Phe Gly Arg Ile Asp Val
Val Val Asn Asn 85 90 95gct gga att
ctg agg gat cgt tcc ttt gct agg ata agt gat gaa gac 393Ala Gly Ile
Leu Arg Asp Arg Ser Phe Ala Arg Ile Ser Asp Glu Asp100
105 110 115tgg gat ata atc cac aga gtt
cat ttg cgg ggt tca ttc caa gtg aca 441Trp Asp Ile Ile His Arg Val
His Leu Arg Gly Ser Phe Gln Val Thr 120
125 130cgg gca gca tgg gaa cac atg aag aaa cag aag tat
gga agg att att 489Arg Ala Ala Trp Glu His Met Lys Lys Gln Lys Tyr
Gly Arg Ile Ile 135 140 145atg
act tca tca gct tca gga ata tat ggc aac ttt ggc cag gcc aat 537Met
Thr Ser Ser Ala Ser Gly Ile Tyr Gly Asn Phe Gly Gln Ala Asn 150
155 160tat agt gct gca aag ttg ggt ctt ctg
ggc ctt gca aat tct ctt gca 585Tyr Ser Ala Ala Lys Leu Gly Leu Leu
Gly Leu Ala Asn Ser Leu Ala 165 170
175att gaa ggc agg aaa agc aac att cat tgt aac acc att gct cct aat
633Ile Glu Gly Arg Lys Ser Asn Ile His Cys Asn Thr Ile Ala Pro Asn180
185 190 195gcg gga tca cgg
atg act cag aca gtt atg cct gaa gat ctt gtg gaa 681Ala Gly Ser Arg
Met Thr Gln Thr Val Met Pro Glu Asp Leu Val Glu 200
205 210gcc ctg aag cca gag tat gtg gca cct ctt
gtc ctt tgg ctt tgt cac 729Ala Leu Lys Pro Glu Tyr Val Ala Pro Leu
Val Leu Trp Leu Cys His 215 220
225gag agt tgt gag gag aat ggt ggc ttg ttt gag gtt gga gca gga tgg
777Glu Ser Cys Glu Glu Asn Gly Gly Leu Phe Glu Val Gly Ala Gly Trp
230 235 240att gga aaa tta cgc tgg gag
cgg act ctt gga gct att gta aga caa 825Ile Gly Lys Leu Arg Trp Glu
Arg Thr Leu Gly Ala Ile Val Arg Gln 245 250
255aag aat cac cca atg act cct gag gca gtc aag gct aac tgg aag aag
873Lys Asn His Pro Met Thr Pro Glu Ala Val Lys Ala Asn Trp Lys Lys260
265 270 275atc tgt gac ttt
gag aat gcc agc aag cct cag agt atc caa gaa tca 921Ile Cys Asp Phe
Glu Asn Ala Ser Lys Pro Gln Ser Ile Gln Glu Ser 280
285 290act ggc agt ata att gaa gtt ctg agt aaa
ata gat tca gaa gga gga 969Thr Gly Ser Ile Ile Glu Val Leu Ser Lys
Ile Asp Ser Glu Gly Gly 295 300
305gtt tca gca aat cat act agt cgt gca acg tct aca gca aca tca gga
1017Val Ser Ala Asn His Thr Ser Arg Ala Thr Ser Thr Ala Thr Ser Gly
310 315 320ttt gct gga gct att ggc cag
aaa ctc cct cca ttt tct tat gct tat 1065Phe Ala Gly Ala Ile Gly Gln
Lys Leu Pro Pro Phe Ser Tyr Ala Tyr 325 330
335acg gaa ctg gaa gct att atg tat gcc ctt gga gtg gga gcg tca atc
1113Thr Glu Leu Glu Ala Ile Met Tyr Ala Leu Gly Val Gly Ala Ser Ile340
345 350 355aag gat cca aaa
gat ttg aaa ttt att tat gaa gga agt tct gat ttc 1161Lys Asp Pro Lys
Asp Leu Lys Phe Ile Tyr Glu Gly Ser Ser Asp Phe 360
365 370tcc tgt ttg ccc acc ttc gga gtt atc ata
ggt cag aaa tct atg atg 1209Ser Cys Leu Pro Thr Phe Gly Val Ile Ile
Gly Gln Lys Ser Met Met 375 380
385ggt gga gga tta gca gaa att cct gga ctt tca atc aac ttt gca aag
1257Gly Gly Gly Leu Ala Glu Ile Pro Gly Leu Ser Ile Asn Phe Ala Lys
390 395 400gtt ctt cat gga gag cag tac
tta gag tta tat aaa cca ctt ccc aga 1305Val Leu His Gly Glu Gln Tyr
Leu Glu Leu Tyr Lys Pro Leu Pro Arg 405 410
415gca gga aaa tta aaa tgt gaa gca gtt gtt gct gat gtc cta gat aaa
1353Ala Gly Lys Leu Lys Cys Glu Ala Val Val Ala Asp Val Leu Asp Lys420
425 430 435gga tcc ggt gta
gtg att att atg gat gtc tat tct tat tct gag aag 1401Gly Ser Gly Val
Val Ile Ile Met Asp Val Tyr Ser Tyr Ser Glu Lys 440
445 450gaa ctt ata tgc cac aat cag ttc tct ctc
ttt ctt gtt ggc tct gga 1449Glu Leu Ile Cys His Asn Gln Phe Ser Leu
Phe Leu Val Gly Ser Gly 455 460
465ggc ttt ggt gga aaa cgg aca tca gac aaa gtc aag gta gct gta gcc
1497Gly Phe Gly Gly Lys Arg Thr Ser Asp Lys Val Lys Val Ala Val Ala
470 475 480ata cct aat aga cct cct gat
gct gta ctt aca gat acc acc tct ctt 1545Ile Pro Asn Arg Pro Pro Asp
Ala Val Leu Thr Asp Thr Thr Ser Leu 485 490
495aat cag gct gct ttg tac cgc ctc agt gga gac tgg aat ccc tta cac
1593Asn Gln Ala Ala Leu Tyr Arg Leu Ser Gly Asp Trp Asn Pro Leu His500
505 510 515att gat cct aac
ttt gct agt cta gca ggt ttt gac aag ccc ata tta 1641Ile Asp Pro Asn
Phe Ala Ser Leu Ala Gly Phe Asp Lys Pro Ile Leu 520
525 530cat gga tta tgt aca ttt gga ttt tct gcc
agg cgt gtg tta cag cag 1689His Gly Leu Cys Thr Phe Gly Phe Ser Ala
Arg Arg Val Leu Gln Gln 535 540
545ttt gca gat aat gat gtg tca aga ttc aag gca att aag gct cgt ttt
1737Phe Ala Asp Asn Asp Val Ser Arg Phe Lys Ala Ile Lys Ala Arg Phe
550 555 560gca aaa cca gta tat cca gga
caa act cta caa act gag atg tgg aag 1785Ala Lys Pro Val Tyr Pro Gly
Gln Thr Leu Gln Thr Glu Met Trp Lys 565 570
575gaa gga aac aga att cat ttt caa acc aag gtc caa gaa act gga gac
1833Glu Gly Asn Arg Ile His Phe Gln Thr Lys Val Gln Glu Thr Gly Asp580
585 590 595att gtc att tca
aat gca tat gtg gat ctt gca cca aca tct ggt act 1881Ile Val Ile Ser
Asn Ala Tyr Val Asp Leu Ala Pro Thr Ser Gly Thr 600
605 610tca gct aag aca ccc tct gag ggc ggg aag
ctt cag agt acc ttt gta 1929Ser Ala Lys Thr Pro Ser Glu Gly Gly Lys
Leu Gln Ser Thr Phe Val 615 620
625ttt gag gaa ata gga cgc cgc cta aag gat att ggg cct gag gtg gtg
1977Phe Glu Glu Ile Gly Arg Arg Leu Lys Asp Ile Gly Pro Glu Val Val
630 635 640aag aaa gta aat gct gta ttt
gag tgg cat ata acc aaa ggc gga aat 2025Lys Lys Val Asn Ala Val Phe
Glu Trp His Ile Thr Lys Gly Gly Asn 645 650
655att ggg gct aag tgg act att gac ctg aaa agt ggt tct gga aaa gtg
2073Ile Gly Ala Lys Trp Thr Ile Asp Leu Lys Ser Gly Ser Gly Lys Val660
665 670 675tac caa ggc cct
gca aaa ggt gct gct gat aca aca atc ata ctt tca 2121Tyr Gln Gly Pro
Ala Lys Gly Ala Ala Asp Thr Thr Ile Ile Leu Ser 680
685 690gat gaa gat ttc atg gag gtg gtc ctg ggc
aag ctt gac cct cag aag 2169Asp Glu Asp Phe Met Glu Val Val Leu Gly
Lys Leu Asp Pro Gln Lys 695 700
705gca ttc ttt agt ggc agg ctg aag gcc aga ggg aac atc atg ctg agc
2217Ala Phe Phe Ser Gly Arg Leu Lys Ala Arg Gly Asn Ile Met Leu Ser
710 715 720cag aaa ctt cag atg att ctt
aaa gac tac gcc aag ctc tga 2259Gln Lys Leu Gln Met Ile Leu
Lys Asp Tyr Ala Lys Leu 725 730
735agggcacact acactattaa taaaaatgga atcattaaat actctcttca cccaaatatg
2319cttgattatt ctgcaaaagt gattagaact aagatgcagg ggaaattgct taacattttc
2379agatatcaga taactgcaga ttttcatttt ctactaattt tcatgtatca ttatttttac
2439aaggaactat atataagcta gcacatgatt atccttctgt tcttagatct gtatcttcat
2499aataaaaaat tttgcccaag tcctgtttcc ttagaatttg tgatagcatt gataagttga
2559aaggaaaatt aaatcaataa aggcctttga tacc
259314736PRTHomo sapiens 14Met Gly Ser Pro Leu Arg Phe Asp Gly Arg Val
Val Leu Val Thr Gly1 5 10
15Ala Gly Ala Gly Leu Gly Arg Ala Tyr Ala Leu Ala Phe Ala Glu Arg
20 25 30Gly Ala Leu Val Val Val Asn
Asp Leu Gly Gly Asp Phe Lys Gly Val 35 40
45Gly Lys Gly Ser Leu Ala Ala Asp Lys Val Val Glu Glu Ile Arg
Arg 50 55 60Arg Gly Gly Lys Ala Val
Ala Asn Tyr Asp Ser Val Glu Glu Gly Glu65 70
75 80Lys Val Val Lys Thr Ala Leu Asp Ala Phe Gly
Arg Ile Asp Val Val 85 90
95Val Asn Asn Ala Gly Ile Leu Arg Asp Arg Ser Phe Ala Arg Ile Ser
100 105 110Asp Glu Asp Trp Asp Ile
Ile His Arg Val His Leu Arg Gly Ser Phe 115 120
125Gln Val Thr Arg Ala Ala Trp Glu His Met Lys Lys Gln Lys
Tyr Gly 130 135 140Arg Ile Ile Met Thr
Ser Ser Ala Ser Gly Ile Tyr Gly Asn Phe Gly145 150
155 160Gln Ala Asn Tyr Ser Ala Ala Lys Leu Gly
Leu Leu Gly Leu Ala Asn 165 170
175Ser Leu Ala Ile Glu Gly Arg Lys Ser Asn Ile His Cys Asn Thr Ile
180 185 190Ala Pro Asn Ala Gly
Ser Arg Met Thr Gln Thr Val Met Pro Glu Asp 195
200 205Leu Val Glu Ala Leu Lys Pro Glu Tyr Val Ala Pro
Leu Val Leu Trp 210 215 220Leu Cys His
Glu Ser Cys Glu Glu Asn Gly Gly Leu Phe Glu Val Gly225
230 235 240Ala Gly Trp Ile Gly Lys Leu
Arg Trp Glu Arg Thr Leu Gly Ala Ile 245
250 255Val Arg Gln Lys Asn His Pro Met Thr Pro Glu Ala
Val Lys Ala Asn 260 265 270Trp
Lys Lys Ile Cys Asp Phe Glu Asn Ala Ser Lys Pro Gln Ser Ile 275
280 285Gln Glu Ser Thr Gly Ser Ile Ile Glu
Val Leu Ser Lys Ile Asp Ser 290 295
300Glu Gly Gly Val Ser Ala Asn His Thr Ser Arg Ala Thr Ser Thr Ala305
310 315 320Thr Ser Gly Phe
Ala Gly Ala Ile Gly Gln Lys Leu Pro Pro Phe Ser 325
330 335Tyr Ala Tyr Thr Glu Leu Glu Ala Ile Met
Tyr Ala Leu Gly Val Gly 340 345
350Ala Ser Ile Lys Asp Pro Lys Asp Leu Lys Phe Ile Tyr Glu Gly Ser
355 360 365Ser Asp Phe Ser Cys Leu Pro
Thr Phe Gly Val Ile Ile Gly Gln Lys 370 375
380Ser Met Met Gly Gly Gly Leu Ala Glu Ile Pro Gly Leu Ser Ile
Asn385 390 395 400Phe Ala
Lys Val Leu His Gly Glu Gln Tyr Leu Glu Leu Tyr Lys Pro
405 410 415Leu Pro Arg Ala Gly Lys Leu
Lys Cys Glu Ala Val Val Ala Asp Val 420 425
430Leu Asp Lys Gly Ser Gly Val Val Ile Ile Met Asp Val Tyr
Ser Tyr 435 440 445Ser Glu Lys Glu
Leu Ile Cys His Asn Gln Phe Ser Leu Phe Leu Val 450
455 460Gly Ser Gly Gly Phe Gly Gly Lys Arg Thr Ser Asp
Lys Val Lys Val465 470 475
480Ala Val Ala Ile Pro Asn Arg Pro Pro Asp Ala Val Leu Thr Asp Thr
485 490 495Thr Ser Leu Asn Gln
Ala Ala Leu Tyr Arg Leu Ser Gly Asp Trp Asn 500
505 510Pro Leu His Ile Asp Pro Asn Phe Ala Ser Leu Ala
Gly Phe Asp Lys 515 520 525Pro Ile
Leu His Gly Leu Cys Thr Phe Gly Phe Ser Ala Arg Arg Val 530
535 540Leu Gln Gln Phe Ala Asp Asn Asp Val Ser Arg
Phe Lys Ala Ile Lys545 550 555
560Ala Arg Phe Ala Lys Pro Val Tyr Pro Gly Gln Thr Leu Gln Thr Glu
565 570 575Met Trp Lys Glu
Gly Asn Arg Ile His Phe Gln Thr Lys Val Gln Glu 580
585 590Thr Gly Asp Ile Val Ile Ser Asn Ala Tyr Val
Asp Leu Ala Pro Thr 595 600 605Ser
Gly Thr Ser Ala Lys Thr Pro Ser Glu Gly Gly Lys Leu Gln Ser 610
615 620Thr Phe Val Phe Glu Glu Ile Gly Arg Arg
Leu Lys Asp Ile Gly Pro625 630 635
640Glu Val Val Lys Lys Val Asn Ala Val Phe Glu Trp His Ile Thr
Lys 645 650 655Gly Gly Asn
Ile Gly Ala Lys Trp Thr Ile Asp Leu Lys Ser Gly Ser 660
665 670Gly Lys Val Tyr Gln Gly Pro Ala Lys Gly
Ala Ala Asp Thr Thr Ile 675 680
685Ile Leu Ser Asp Glu Asp Phe Met Glu Val Val Leu Gly Lys Leu Asp 690
695 700Pro Gln Lys Ala Phe Phe Ser Gly
Arg Leu Lys Ala Arg Gly Asn Ile705 710
715 720Met Leu Ser Gln Lys Leu Gln Met Ile Leu Lys Asp
Tyr Ala Lys Leu 725 730
735152113DNAHomo sapiensCDS(63)..(1694) 15gtgcggttgg gaacgcggag
cggacggatt cgattcaacg gggttccgga ccgcgctgcg 60ct atg gag cag gtc aat
gag ctg aag gag aaa ggc aac aag gcc ctg 107 Met Glu Gln Val Asn
Glu Leu Lys Glu Lys Gly Asn Lys Ala Leu 1 5
10 15agc gtg ggt aac atc gat gat gcc tta cag tgc tac
tcc gaa gct att 155Ser Val Gly Asn Ile Asp Asp Ala Leu Gln Cys Tyr
Ser Glu Ala Ile 20 25
30aag ctg gat ccc cac aac cac gtg ctg tac agc aac cgt tct gct gcc
203Lys Leu Asp Pro His Asn His Val Leu Tyr Ser Asn Arg Ser Ala Ala
35 40 45tat gcc aag aaa gga gac tac
cag aag gct tat gag gat ggc tgc aag 251Tyr Ala Lys Lys Gly Asp Tyr
Gln Lys Ala Tyr Glu Asp Gly Cys Lys 50 55
60act gtc gac cta aag cct gac tgg ggc aag ggc tat tca cga aaa
gca 299Thr Val Asp Leu Lys Pro Asp Trp Gly Lys Gly Tyr Ser Arg Lys
Ala 65 70 75gca gct cta gag ttc tta
aac cgc ttt gaa gaa gcc aag cga acc tat 347Ala Ala Leu Glu Phe Leu
Asn Arg Phe Glu Glu Ala Lys Arg Thr Tyr80 85
90 95gag gag ggc tta aaa cac gag gca aat aac cct
caa ctg aaa gag ggt 395Glu Glu Gly Leu Lys His Glu Ala Asn Asn Pro
Gln Leu Lys Glu Gly 100 105
110tta cag aat atg gag gcc agg ttg gca gag aga aaa ttc atg aac cct
443Leu Gln Asn Met Glu Ala Arg Leu Ala Glu Arg Lys Phe Met Asn Pro
115 120 125ttc aac atg cct aat ctg
tat cag aag ttg gag agt gat ccc agg aca 491Phe Asn Met Pro Asn Leu
Tyr Gln Lys Leu Glu Ser Asp Pro Arg Thr 130 135
140agg aca cta ctc agt gat cct acc tac cgg gag ctg ata gag
cag cta 539Arg Thr Leu Leu Ser Asp Pro Thr Tyr Arg Glu Leu Ile Glu
Gln Leu 145 150 155cga aac aag cct tct
gac ctg ggc acg aaa cta caa gat ccc cgg atc 587Arg Asn Lys Pro Ser
Asp Leu Gly Thr Lys Leu Gln Asp Pro Arg Ile160 165
170 175atg acc act ctc agc gtc ctc ctt ggg gtc
gat ctg ggc agt atg gat 635Met Thr Thr Leu Ser Val Leu Leu Gly Val
Asp Leu Gly Ser Met Asp 180 185
190gag gag gaa gag att gca aca cct cca cca cca ccc cct ccc aaa aag
683Glu Glu Glu Glu Ile Ala Thr Pro Pro Pro Pro Pro Pro Pro Lys Lys
195 200 205gag acc aag cca gag cca
atg gaa gaa gat ctt cca gag aat aag aag 731Glu Thr Lys Pro Glu Pro
Met Glu Glu Asp Leu Pro Glu Asn Lys Lys 210 215
220cag gca ctg aaa gaa aaa gag ctg ggg aac gat gcc tac aag
aag aaa 779Gln Ala Leu Lys Glu Lys Glu Leu Gly Asn Asp Ala Tyr Lys
Lys Lys 225 230 235gac ttt gac aca gcc
ttg aag cat tac gac aaa gcc aag gag ctg gac 827Asp Phe Asp Thr Ala
Leu Lys His Tyr Asp Lys Ala Lys Glu Leu Asp240 245
250 255ccc act aac atg act tac att acc aat caa
gca gcg gta tac ttt gaa 875Pro Thr Asn Met Thr Tyr Ile Thr Asn Gln
Ala Ala Val Tyr Phe Glu 260 265
270aag ggc gac tac aat aag tgc cgg gag ctt tgt gag aag gcc att gaa
923Lys Gly Asp Tyr Asn Lys Cys Arg Glu Leu Cys Glu Lys Ala Ile Glu
275 280 285gtg ggg aga gaa aac cga
gaa gac tat cga cag att gcc aaa gca tat 971Val Gly Arg Glu Asn Arg
Glu Asp Tyr Arg Gln Ile Ala Lys Ala Tyr 290 295
300gct cga att ggc aac tcc tac ttc aaa gaa gaa aag tac aag
gat gcc 1019Ala Arg Ile Gly Asn Ser Tyr Phe Lys Glu Glu Lys Tyr Lys
Asp Ala 305 310 315atc cat ttc tat aac
aag tct ctg gca gag cac cga acc cca gat gtg 1067Ile His Phe Tyr Asn
Lys Ser Leu Ala Glu His Arg Thr Pro Asp Val320 325
330 335ctc aag aaa tgc cag cag gca gag aaa atc
ctg aag gag caa gag cgg 1115Leu Lys Lys Cys Gln Gln Ala Glu Lys Ile
Leu Lys Glu Gln Glu Arg 340 345
350ctg gcc tac ata aac ccc gac ctg gct ttg gag gag aag aac aaa ggc
1163Leu Ala Tyr Ile Asn Pro Asp Leu Ala Leu Glu Glu Lys Asn Lys Gly
355 360 365aac gag tgt ttt cag aaa
ggg gac tat ccc cag gcc atg aag cat tat 1211Asn Glu Cys Phe Gln Lys
Gly Asp Tyr Pro Gln Ala Met Lys His Tyr 370 375
380aca gaa gcc atc aaa agg aac ccg aaa gat gcc aaa tta tac
agc aat 1259Thr Glu Ala Ile Lys Arg Asn Pro Lys Asp Ala Lys Leu Tyr
Ser Asn 385 390 395cga gct gcc tgc tac
acc aaa ctc ctg gag ttc cag ctg gca ctc aag 1307Arg Ala Ala Cys Tyr
Thr Lys Leu Leu Glu Phe Gln Leu Ala Leu Lys400 405
410 415gac tgt gag gaa tgt atc cag ctg gag ccg
acc ttc atc aag ggt tat 1355Asp Cys Glu Glu Cys Ile Gln Leu Glu Pro
Thr Phe Ile Lys Gly Tyr 420 425
430aca cgg aaa gcc gct gcg ctg gaa gcg atg aag gac tac acc aaa gcc
1403Thr Arg Lys Ala Ala Ala Leu Glu Ala Met Lys Asp Tyr Thr Lys Ala
435 440 445atg gat gtg tac cag aag
gcg cta gac ctg gac tcc agc tgt aag gag 1451Met Asp Val Tyr Gln Lys
Ala Leu Asp Leu Asp Ser Ser Cys Lys Glu 450 455
460gcg gca gac ggc tac cag cgc tgt atg atg gcg cag tac aac
cgg cac 1499Ala Ala Asp Gly Tyr Gln Arg Cys Met Met Ala Gln Tyr Asn
Arg His 465 470 475gac agc ccc gaa gat
gtg aag cga cga gcc atg gcc gac cct gag gtg 1547Asp Ser Pro Glu Asp
Val Lys Arg Arg Ala Met Ala Asp Pro Glu Val480 485
490 495cag cag atc atg agt gac cca gcc atg cgc
ctt atc ctg gaa cag atg 1595Gln Gln Ile Met Ser Asp Pro Ala Met Arg
Leu Ile Leu Glu Gln Met 500 505
510cag aag gac ccc cag gca ctc agc gaa cac tta aag aat cct gta ata
1643Gln Lys Asp Pro Gln Ala Leu Ser Glu His Leu Lys Asn Pro Val Ile
515 520 525gca cag aag atc cag aag
ctg atg gat gtg ggt ctg att gca att cgg 1691Ala Gln Lys Ile Gln Lys
Leu Met Asp Val Gly Leu Ile Ala Ile Arg 530 535
540tga tgacttgttc atcccccctt cccttcgccc tcatgtggaa
agaggagctg 1744ggaccgcggc gagcagcacg gagcggaagg gagagcaggg
gagagaaggc ctcatctctc 1804 tatatttata cataaccccg gggaagacac agagactcgt
acctgcgctg tttgtgccgc 1864cgctgcctct gggccctccc agcacacgca tggtctcttc
accgctgccc tcgagttcca 1924tgtctctttc ccctgcccct agttgctgtc tcggctgctc
tcccatagtt ggtttttttt 1984ttatttgggg cagtgggcat gttatgggga ggggaggggg
ttcttccagc ctcaggtccc 2044agctgtctca cgttgtttat tctgcgtccc cttctccaat
aaaacaagcc agttgggcgt 2104ggttataac
211316543PRTHomo sapiens 16Met Glu Gln Val Asn Glu
Leu Lys Glu Lys Gly Asn Lys Ala Leu Ser1 5
10 15Val Gly Asn Ile Asp Asp Ala Leu Gln Cys Tyr Ser
Glu Ala Ile Lys 20 25 30Leu
Asp Pro His Asn His Val Leu Tyr Ser Asn Arg Ser Ala Ala Tyr 35
40 45Ala Lys Lys Gly Asp Tyr Gln Lys Ala
Tyr Glu Asp Gly Cys Lys Thr 50 55
60Val Asp Leu Lys Pro Asp Trp Gly Lys Gly Tyr Ser Arg Lys Ala Ala65
70 75 80Ala Leu Glu Phe Leu
Asn Arg Phe Glu Glu Ala Lys Arg Thr Tyr Glu 85
90 95Glu Gly Leu Lys His Glu Ala Asn Asn Pro Gln
Leu Lys Glu Gly Leu 100 105
110Gln Asn Met Glu Ala Arg Leu Ala Glu Arg Lys Phe Met Asn Pro Phe
115 120 125Asn Met Pro Asn Leu Tyr Gln
Lys Leu Glu Ser Asp Pro Arg Thr Arg 130 135
140Thr Leu Leu Ser Asp Pro Thr Tyr Arg Glu Leu Ile Glu Gln Leu
Arg145 150 155 160Asn Lys
Pro Ser Asp Leu Gly Thr Lys Leu Gln Asp Pro Arg Ile Met
165 170 175Thr Thr Leu Ser Val Leu Leu
Gly Val Asp Leu Gly Ser Met Asp Glu 180 185
190Glu Glu Glu Ile Ala Thr Pro Pro Pro Pro Pro Pro Pro Lys
Lys Glu 195 200 205Thr Lys Pro Glu
Pro Met Glu Glu Asp Leu Pro Glu Asn Lys Lys Gln 210
215 220Ala Leu Lys Glu Lys Glu Leu Gly Asn Asp Ala Tyr
Lys Lys Lys Asp225 230 235
240Phe Asp Thr Ala Leu Lys His Tyr Asp Lys Ala Lys Glu Leu Asp Pro
245 250 255Thr Asn Met Thr Tyr
Ile Thr Asn Gln Ala Ala Val Tyr Phe Glu Lys 260
265 270Gly Asp Tyr Asn Lys Cys Arg Glu Leu Cys Glu Lys
Ala Ile Glu Val 275 280 285Gly Arg
Glu Asn Arg Glu Asp Tyr Arg Gln Ile Ala Lys Ala Tyr Ala 290
295 300Arg Ile Gly Asn Ser Tyr Phe Lys Glu Glu Lys
Tyr Lys Asp Ala Ile305 310 315
320His Phe Tyr Asn Lys Ser Leu Ala Glu His Arg Thr Pro Asp Val Leu
325 330 335Lys Lys Cys Gln
Gln Ala Glu Lys Ile Leu Lys Glu Gln Glu Arg Leu 340
345 350Ala Tyr Ile Asn Pro Asp Leu Ala Leu Glu Glu
Lys Asn Lys Gly Asn 355 360 365Glu
Cys Phe Gln Lys Gly Asp Tyr Pro Gln Ala Met Lys His Tyr Thr 370
375 380Glu Ala Ile Lys Arg Asn Pro Lys Asp Ala
Lys Leu Tyr Ser Asn Arg385 390 395
400Ala Ala Cys Tyr Thr Lys Leu Leu Glu Phe Gln Leu Ala Leu Lys
Asp 405 410 415Cys Glu Glu
Cys Ile Gln Leu Glu Pro Thr Phe Ile Lys Gly Tyr Thr 420
425 430Arg Lys Ala Ala Ala Leu Glu Ala Met Lys
Asp Tyr Thr Lys Ala Met 435 440
445Asp Val Tyr Gln Lys Ala Leu Asp Leu Asp Ser Ser Cys Lys Glu Ala 450
455 460Ala Asp Gly Tyr Gln Arg Cys Met
Met Ala Gln Tyr Asn Arg His Asp465 470
475 480Ser Pro Glu Asp Val Lys Arg Arg Ala Met Ala Asp
Pro Glu Val Gln 485 490
495Gln Ile Met Ser Asp Pro Ala Met Arg Leu Ile Leu Glu Gln Met Gln
500 505 510Lys Asp Pro Gln Ala Leu
Ser Glu His Leu Lys Asn Pro Val Ile Ala 515 520
525Gln Lys Ile Gln Lys Leu Met Asp Val Gly Leu Ile Ala Ile
Arg 530 535 540172033DNAHomo
sapiensCDS(29)..(1705) 17ggacgagcag cggaggcggt cgggagcg atg gtg aag atg
gcg gcg gcg ggc 52 Met Val Lys Met
Ala Ala Ala Gly 1 5ggc gga
ggc ggc ggt ggc cgc tac tac ggc ggc ggc agt gag ggc ggc 100Gly Gly
Gly Gly Gly Gly Arg Tyr Tyr Gly Gly Gly Ser Glu Gly Gly 10
15 20cgg gcc cct aag cgg ctc aag act gac aac gcc
ggc gac cag cac gga 148Arg Ala Pro Lys Arg Leu Lys Thr Asp Asn Ala
Gly Asp Gln His Gly25 30 35
40ggc ggc ggc ggt ggc ggt gga gga gcc ggg gcg gcg ggc ggc ggc ggc
196Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Ala Gly Gly Gly Gly
45 50 55ggt ggg gag aac tac
gat gac ccg cac aaa acc cct gcc tcc cca gtt 244Gly Gly Glu Asn Tyr
Asp Asp Pro His Lys Thr Pro Ala Ser Pro Val 60
65 70gtc cac atc agg ggc ctg att gac ggt gtg gtg gaa
gca gac ctt gtg 292Val His Ile Arg Gly Leu Ile Asp Gly Val Val Glu
Ala Asp Leu Val 75 80 85gag gcc
ttg cag gag ttt gga ccc atc agc tat gtg gtg gta atg cct 340Glu Ala
Leu Gln Glu Phe Gly Pro Ile Ser Tyr Val Val Val Met Pro 90
95 100aaa aag aga caa gca ctg gtg gag ttt gaa gat
gtg ttg ggg gct tgc 388Lys Lys Arg Gln Ala Leu Val Glu Phe Glu Asp
Val Leu Gly Ala Cys105 110 115
120aac gca gtg aac tac gca gcc gac aac caa ata tac att gct ggt cac
436Asn Ala Val Asn Tyr Ala Ala Asp Asn Gln Ile Tyr Ile Ala Gly His
125 130 135cca gct ttt gtc aac
tac tct acc agc cag aag atc tcc cgc cct ggg 484Pro Ala Phe Val Asn
Tyr Ser Thr Ser Gln Lys Ile Ser Arg Pro Gly 140
145 150gac tcg gat gac tcc cgg agc gtg aac agt gtg ctt
ctc ttt acc atc 532Asp Ser Asp Asp Ser Arg Ser Val Asn Ser Val Leu
Leu Phe Thr Ile 155 160 165ctg aac
ccc att tat tcg atc acc acg gat gtt ctt tac act atc tgt 580Leu Asn
Pro Ile Tyr Ser Ile Thr Thr Asp Val Leu Tyr Thr Ile Cys 170
175 180aat cct tgt ggc cct gtc cag aga att gtc att
ttc agg aag aat gga 628Asn Pro Cys Gly Pro Val Gln Arg Ile Val Ile
Phe Arg Lys Asn Gly185 190 195
200gtt cag gcg atg gtg gaa ttt gac tca gtt caa agt gcc cag cgg gcc
676Val Gln Ala Met Val Glu Phe Asp Ser Val Gln Ser Ala Gln Arg Ala
205 210 215aag gcc tct ctc aat
ggg gct gat atc tat tct ggc tgt tgc act ctg 724Lys Ala Ser Leu Asn
Gly Ala Asp Ile Tyr Ser Gly Cys Cys Thr Leu 220
225 230aag atc gaa tac gca aag cct aca cgc ttg aat gtg
ttc aag aat gat 772Lys Ile Glu Tyr Ala Lys Pro Thr Arg Leu Asn Val
Phe Lys Asn Asp 235 240 245cag gat
act tgg gac tac aca aac ccc aat ctc agt gga caa ggt gac 820Gln Asp
Thr Trp Asp Tyr Thr Asn Pro Asn Leu Ser Gly Gln Gly Asp 250
255 260cct ggc agc aac ccc aac aaa cgc cag agg cag
ccc cct ctc ctg gga 868Pro Gly Ser Asn Pro Asn Lys Arg Gln Arg Gln
Pro Pro Leu Leu Gly265 270 275
280gat cac ccc gca gaa tat gga ggg ccc cac ggt ggg tac cac agc cat
916Asp His Pro Ala Glu Tyr Gly Gly Pro His Gly Gly Tyr His Ser His
285 290 295tac cat gat gag ggc
tac ggg ccc ccc cca cct cac tac gaa ggg aga 964Tyr His Asp Glu Gly
Tyr Gly Pro Pro Pro Pro His Tyr Glu Gly Arg 300
305 310agg atg ggt cca cca gtg ggg ggt cac cgt cgg ggc
cca agt cgc tac 1012Arg Met Gly Pro Pro Val Gly Gly His Arg Arg Gly
Pro Ser Arg Tyr 315 320 325ggc ccc
cag tat ggg cac ccc cca ccc cct ccc cca cca ccc gag tat 1060Gly Pro
Gln Tyr Gly His Pro Pro Pro Pro Pro Pro Pro Pro Glu Tyr 330
335 340ggc cct cac gcc gac agc cct gtg ctc atg gtc
tat ggc ttg gat caa 1108Gly Pro His Ala Asp Ser Pro Val Leu Met Val
Tyr Gly Leu Asp Gln345 350 355
360tct aag atg aac ggt gac cga gtc ttc aat gtc ttc tgc tta tat ggc
1156Ser Lys Met Asn Gly Asp Arg Val Phe Asn Val Phe Cys Leu Tyr Gly
365 370 375aat gtg gag aag gtg
aaa ttc atg aaa agc aag ccg ggg gcc gcc atg 1204Asn Val Glu Lys Val
Lys Phe Met Lys Ser Lys Pro Gly Ala Ala Met 380
385 390gtg gag atg gct gat ggc tac gct gta gac cgg gcc
att acc cac ctc 1252Val Glu Met Ala Asp Gly Tyr Ala Val Asp Arg Ala
Ile Thr His Leu 395 400 405aac aac
aac ttc atg ttt ggg cag aag ctg aat gtc tgt gtc tcc aag 1300Asn Asn
Asn Phe Met Phe Gly Gln Lys Leu Asn Val Cys Val Ser Lys 410
415 420cag cca gcc atc atg cct ggt cag tca tac ggg
ttg gaa gac ggg tct 1348Gln Pro Ala Ile Met Pro Gly Gln Ser Tyr Gly
Leu Glu Asp Gly Ser425 430 435
440tgc agt tac aaa gac ttc agt gaa tcc cgg aac aat cgg ttc tcc acc
1396Cys Ser Tyr Lys Asp Phe Ser Glu Ser Arg Asn Asn Arg Phe Ser Thr
445 450 455cca gag cag gca gcc
aag aac cgc atc cag cac ccc agc aac gtg ctg 1444Pro Glu Gln Ala Ala
Lys Asn Arg Ile Gln His Pro Ser Asn Val Leu 460
465 470cac ttc ttc aac gcc ccg ctg gag gtg acc gag gag
aac ttc ttt gag 1492His Phe Phe Asn Ala Pro Leu Glu Val Thr Glu Glu
Asn Phe Phe Glu 475 480 485atc tgc
gat gag ctg gga gtg aag cgg cca tct tct gtg aaa gta ttc 1540Ile Cys
Asp Glu Leu Gly Val Lys Arg Pro Ser Ser Val Lys Val Phe 490
495 500tca ggc aaa agt gag cgc agc tcc tct gga ctg
ctg gag tgg gaa tcc 1588Ser Gly Lys Ser Glu Arg Ser Ser Ser Gly Leu
Leu Glu Trp Glu Ser505 510 515
520aag agc gat gcc ctg gag act ctg ggc ttc ctg aac cat tac cag atg
1636Lys Ser Asp Ala Leu Glu Thr Leu Gly Phe Leu Asn His Tyr Gln Met
525 530 535aaa aac cca aat ggt
cca tac cct tac act ctg aag ttg tgt ttc tcc 1684Lys Asn Pro Asn Gly
Pro Tyr Pro Tyr Thr Leu Lys Leu Cys Phe Ser 540
545 550act gct cag cac gcc tcc taa ttaggtgcct aggaagagtc
ccatctgagc 1735Thr Ala Gln His Ala Ser 555aggaagacat
ttctctttcc tttatgccat tttttgtttt tgttatttgc aaaagatctt 1795gtattccttt
tttttttttt ttttttttaa atgctaggtt tgtagaggct tacttaacct 1855taatggaaac
gctggaaatc tgcaggggga gggagagggg aactgttatc tcccaagatt 1915aaccttcact
tttaaaaaat tattgtacat gtgatttttt tttttcctgt tcatacattt 1975gtgctgccca
tgtactcttg gcacatttca ataaaattgt ttggaaaata aacacagc 203318558PRTHomo
sapiens 18Met Val Lys Met Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Arg
Tyr1 5 10 15Tyr Gly Gly
Gly Ser Glu Gly Gly Arg Ala Pro Lys Arg Leu Lys Thr 20
25 30Asp Asn Ala Gly Asp Gln His Gly Gly Gly
Gly Gly Gly Gly Gly Gly 35 40
45Ala Gly Ala Ala Gly Gly Gly Gly Gly Gly Glu Asn Tyr Asp Asp Pro 50
55 60His Lys Thr Pro Ala Ser Pro Val Val
His Ile Arg Gly Leu Ile Asp65 70 75
80Gly Val Val Glu Ala Asp Leu Val Glu Ala Leu Gln Glu Phe
Gly Pro 85 90 95Ile Ser
Tyr Val Val Val Met Pro Lys Lys Arg Gln Ala Leu Val Glu 100
105 110Phe Glu Asp Val Leu Gly Ala Cys Asn
Ala Val Asn Tyr Ala Ala Asp 115 120
125Asn Gln Ile Tyr Ile Ala Gly His Pro Ala Phe Val Asn Tyr Ser Thr
130 135 140Ser Gln Lys Ile Ser Arg Pro
Gly Asp Ser Asp Asp Ser Arg Ser Val145 150
155 160Asn Ser Val Leu Leu Phe Thr Ile Leu Asn Pro Ile
Tyr Ser Ile Thr 165 170
175Thr Asp Val Leu Tyr Thr Ile Cys Asn Pro Cys Gly Pro Val Gln Arg
180 185 190Ile Val Ile Phe Arg Lys
Asn Gly Val Gln Ala Met Val Glu Phe Asp 195 200
205Ser Val Gln Ser Ala Gln Arg Ala Lys Ala Ser Leu Asn Gly
Ala Asp 210 215 220Ile Tyr Ser Gly Cys
Cys Thr Leu Lys Ile Glu Tyr Ala Lys Pro Thr225 230
235 240Arg Leu Asn Val Phe Lys Asn Asp Gln Asp
Thr Trp Asp Tyr Thr Asn 245 250
255Pro Asn Leu Ser Gly Gln Gly Asp Pro Gly Ser Asn Pro Asn Lys Arg
260 265 270Gln Arg Gln Pro Pro
Leu Leu Gly Asp His Pro Ala Glu Tyr Gly Gly 275
280 285Pro His Gly Gly Tyr His Ser His Tyr His Asp Glu
Gly Tyr Gly Pro 290 295 300Pro Pro Pro
His Tyr Glu Gly Arg Arg Met Gly Pro Pro Val Gly Gly305
310 315 320His Arg Arg Gly Pro Ser Arg
Tyr Gly Pro Gln Tyr Gly His Pro Pro 325
330 335Pro Pro Pro Pro Pro Pro Glu Tyr Gly Pro His Ala
Asp Ser Pro Val 340 345 350Leu
Met Val Tyr Gly Leu Asp Gln Ser Lys Met Asn Gly Asp Arg Val 355
360 365Phe Asn Val Phe Cys Leu Tyr Gly Asn
Val Glu Lys Val Lys Phe Met 370 375
380Lys Ser Lys Pro Gly Ala Ala Met Val Glu Met Ala Asp Gly Tyr Ala385
390 395 400Val Asp Arg Ala
Ile Thr His Leu Asn Asn Asn Phe Met Phe Gly Gln 405
410 415Lys Leu Asn Val Cys Val Ser Lys Gln Pro
Ala Ile Met Pro Gly Gln 420 425
430Ser Tyr Gly Leu Glu Asp Gly Ser Cys Ser Tyr Lys Asp Phe Ser Glu
435 440 445Ser Arg Asn Asn Arg Phe Ser
Thr Pro Glu Gln Ala Ala Lys Asn Arg 450 455
460Ile Gln His Pro Ser Asn Val Leu His Phe Phe Asn Ala Pro Leu
Glu465 470 475 480Val Thr
Glu Glu Asn Phe Phe Glu Ile Cys Asp Glu Leu Gly Val Lys
485 490 495Arg Pro Ser Ser Val Lys Val
Phe Ser Gly Lys Ser Glu Arg Ser Ser 500 505
510Ser Gly Leu Leu Glu Trp Glu Ser Lys Ser Asp Ala Leu Glu
Thr Leu 515 520 525Gly Phe Leu Asn
His Tyr Gln Met Lys Asn Pro Asn Gly Pro Tyr Pro 530
535 540Tyr Thr Leu Lys Leu Cys Phe Ser Thr Ala Gln His
Ala Ser545 550 555193465DNAHomo
sapiensCDS(219)..(2639) 19ctcgcgccag gcgagtctcc gcgtctccct cgcgaactcg
gtgaaaggaa ttggcgccgt 60tcgacaccag gcggatccgc tctgcagcac gaacccatct
ccagccgcag ccgcagccgc 120cgcccgggcc gaggagcagc cgcagcagcc gccaccagtg
gccgagtgag cggagccgag 180tttgaggcag cgcctagcgg tgaatcgggg ccctcacc atg
agt tcc tcg cct gtt 236 Met
Ser Ser Ser Pro Val 1
5aat gta aaa aag ctg aag gtg tcg gag ctg aaa gag gag ctc aag aag
284Asn Val Lys Lys Leu Lys Val Ser Glu Leu Lys Glu Glu Leu Lys Lys
10 15 20cga cgc ctt tct gac aag ggt
ctc aag gcc gag ctc atg gag cga ctc 332Arg Arg Leu Ser Asp Lys Gly
Leu Lys Ala Glu Leu Met Glu Arg Leu 25 30
35cag gct gcg ctg gac gac gag gag gcc ggg ggc cgc ccc gcc atg
gag 380Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly Gly Arg Pro Ala Met
Glu 40 45 50ccc ggg aac ggc agc cta
gac ctg ggc ggg gat tcc gct ggg cgc tcg 428Pro Gly Asn Gly Ser Leu
Asp Leu Gly Gly Asp Ser Ala Gly Arg Ser55 60
65 70gga gca ggc ctc gag cag gag gcc gcg gcc ggc
ggc gat gaa gag gag 476Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala Gly
Gly Asp Glu Glu Glu 75 80
85gag gaa gag gaa gag gag gag gaa gga atc tcc gct ctg gac ggc gac
524Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile Ser Ala Leu Asp Gly Asp
90 95 100cag atg gag cta gga gag
gag aac ggg gcc gcg ggg gcg gcc gac tcg 572Gln Met Glu Leu Gly Glu
Glu Asn Gly Ala Ala Gly Ala Ala Asp Ser 105 110
115ggc ccg atg gag gag gag gag gcc gcc tcg gaa gac gag aac
ggc gac 620Gly Pro Met Glu Glu Glu Glu Ala Ala Ser Glu Asp Glu Asn
Gly Asp 120 125 130gat cag ggt ttc cag
gaa ggg gaa gat gag ctc ggg gac gaa gag gaa 668Asp Gln Gly Phe Gln
Glu Gly Glu Asp Glu Leu Gly Asp Glu Glu Glu135 140
145 150ggc gcg ggc gac gag aac ggg cac ggg gag
cag cag cct caa ccg ccg 716Gly Ala Gly Asp Glu Asn Gly His Gly Glu
Gln Gln Pro Gln Pro Pro 155 160
165gcg acg cag cag caa cag ccc caa cag cag cgc ggg gcc gcc aag gag
764Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln Arg Gly Ala Ala Lys Glu
170 175 180gcc gcg ggg aag agc agc
ggc ccc acc tcg ctg ttc gcg gtg acg gtg 812Ala Ala Gly Lys Ser Ser
Gly Pro Thr Ser Leu Phe Ala Val Thr Val 185 190
195gcg ccg ccc ggg gcg agg cag ggc cag cag cag gcg gga ggg
gac ggc 860Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln Gln Ala Gly Gly
Asp Gly 200 205 210aaa aca gaa cag aaa
ggc gga gat aaa aag agg ggt gtt aaa aga cca 908Lys Thr Glu Gln Lys
Gly Gly Asp Lys Lys Arg Gly Val Lys Arg Pro215 220
225 230cga gaa gat cat ggc cgt gga tat ttt gag
tac att gaa gag aac aag 956Arg Glu Asp His Gly Arg Gly Tyr Phe Glu
Tyr Ile Glu Glu Asn Lys 235 240
245tat agc aga gcc aaa tct cct cag cca cct gtt gaa gaa gaa gat gaa
1004Tyr Ser Arg Ala Lys Ser Pro Gln Pro Pro Val Glu Glu Glu Asp Glu
250 255 260cac ttc gat gac aca gtg
gtt tgt ctt gat act tat aat tgt gat cta 1052His Phe Asp Asp Thr Val
Val Cys Leu Asp Thr Tyr Asn Cys Asp Leu 265 270
275cat ttt aaa ata tca aga gat cgt ctc agt gct tct tcc ctt
aca atg 1100His Phe Lys Ile Ser Arg Asp Arg Leu Ser Ala Ser Ser Leu
Thr Met 280 285 290gag agt ttt gct ttt
ctt tgg gct gga gga aga gca tcc tat ggt gtg 1148Glu Ser Phe Ala Phe
Leu Trp Ala Gly Gly Arg Ala Ser Tyr Gly Val295 300
305 310tca aaa ggc aaa gtg tgt ttt gag atg aag
gtt aca gag aag atc cca 1196Ser Lys Gly Lys Val Cys Phe Glu Met Lys
Val Thr Glu Lys Ile Pro 315 320
325gta agg cat tta tat aca aaa gat att gac ata cat gaa gtt cgt att
1244Val Arg His Leu Tyr Thr Lys Asp Ile Asp Ile His Glu Val Arg Ile
330 335 340ggc tgg tca cta act aca
agt gga atg tta ctt ggt gaa gaa gaa ttt 1292Gly Trp Ser Leu Thr Thr
Ser Gly Met Leu Leu Gly Glu Glu Glu Phe 345 350
355tct tat ggg tat tct cta aaa gga ata aaa aca tgc aac tgt
gag act 1340Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys Thr Cys Asn Cys
Glu Thr 360 365 370gaa gat tat gga gaa
aag ttt gat gaa aat gat gtg att aca tgt ttt 1388Glu Asp Tyr Gly Glu
Lys Phe Asp Glu Asn Asp Val Ile Thr Cys Phe375 380
385 390gct aac ttt gaa agt gat gaa gta gaa ctc
tcg tat gct aag aat gga 1436Ala Asn Phe Glu Ser Asp Glu Val Glu Leu
Ser Tyr Ala Lys Asn Gly 395 400
405caa gat ctt ggc gtt gcc ttc aaa atc agt aag gaa gtt ctt gct gga
1484Gln Asp Leu Gly Val Ala Phe Lys Ile Ser Lys Glu Val Leu Ala Gly
410 415 420cgg cca ctg ttc ccg cat
gtt ctc tgc cac aac tgt gca gtt gaa ttt 1532Arg Pro Leu Phe Pro His
Val Leu Cys His Asn Cys Ala Val Glu Phe 425 430
435aat ttt ggt cag aag gaa aag cca tat ttt cca ata cct gaa
gag tat 1580Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe Pro Ile Pro Glu
Glu Tyr 440 445 450act ttc atc cag aac
gtc ccc tta gag gat cga gtt aga gga cca aag 1628Thr Phe Ile Gln Asn
Val Pro Leu Glu Asp Arg Val Arg Gly Pro Lys455 460
465 470ggg cct gaa gag aag aaa gat tgt gaa gtt
gtg atg atg att ggc ttg 1676Gly Pro Glu Glu Lys Lys Asp Cys Glu Val
Val Met Met Ile Gly Leu 475 480
485cca gga gct gga aaa act acc tgg gtt act aaa cat gca gca gaa aat
1724Pro Gly Ala Gly Lys Thr Thr Trp Val Thr Lys His Ala Ala Glu Asn
490 495 500cca ggg aaa tat aac att
ctt ggc aca aat act att atg gat aag atg 1772Pro Gly Lys Tyr Asn Ile
Leu Gly Thr Asn Thr Ile Met Asp Lys Met 505 510
515atg gtg gca ggt ttt aag aag caa atg gca gat act gga aaa
ctg aac 1820Met Val Ala Gly Phe Lys Lys Gln Met Ala Asp Thr Gly Lys
Leu Asn 520 525 530aca ctg ttg cag aga
gcc ccc cag tgt ctt ggg aaa ttt att gag att 1868Thr Leu Leu Gln Arg
Ala Pro Gln Cys Leu Gly Lys Phe Ile Glu Ile535 540
545 550gct gcc cga aag aag cga aat ttt att ctg
gat cag aca aat gtg tct 1916Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu
Asp Gln Thr Asn Val Ser 555 560
565gct gct gcc cag agg aga aaa atg tgc ctg ttt gca ggc ttc cag cga
1964Ala Ala Ala Gln Arg Arg Lys Met Cys Leu Phe Ala Gly Phe Gln Arg
570 575 580aaa gct gtt gta gtt tgc
cca aaa gat gaa gac tat aag caa aga aca 2012Lys Ala Val Val Val Cys
Pro Lys Asp Glu Asp Tyr Lys Gln Arg Thr 585 590
595cag aag aaa gca gaa gta gag ggg aaa gac cta cca gaa cat
gcg gtc 2060Gln Lys Lys Ala Glu Val Glu Gly Lys Asp Leu Pro Glu His
Ala Val 600 605 610ctc aaa atg aaa gga
aac ttt acc ctc cca gag gta gct gag tgc ttt 2108Leu Lys Met Lys Gly
Asn Phe Thr Leu Pro Glu Val Ala Glu Cys Phe615 620
625 630gat gaa ata acc tat gtt gaa ctt cag aag
gaa gaa gcc caa aaa ctc 2156Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys
Glu Glu Ala Gln Lys Leu 635 640
645ttg gag caa tat aag gaa gaa agc aaa aag gct ctt cca cca gaa aag
2204Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys Ala Leu Pro Pro Glu Lys
650 655 660aaa cag aac act ggc tca
aag aaa agc aat aaa aat aag agt ggc aag 2252Lys Gln Asn Thr Gly Ser
Lys Lys Ser Asn Lys Asn Lys Ser Gly Lys 665 670
675aac cag ttt aac aga ggt ggt ggc cat aga gga cgt gga gga
ttc aat 2300Asn Gln Phe Asn Arg Gly Gly Gly His Arg Gly Arg Gly Gly
Phe Asn 680 685 690atg cgt ggt gga aat
ttc aga gga gga gcc cct ggg aat cgt ggc gga 2348Met Arg Gly Gly Asn
Phe Arg Gly Gly Ala Pro Gly Asn Arg Gly Gly695 700
705 710tat aat agg agg ggc aac atg cca cag aga
ggt ggt ggc ggt gga gga 2396Tyr Asn Arg Arg Gly Asn Met Pro Gln Arg
Gly Gly Gly Gly Gly Gly 715 720
725agt ggt gga atc ggc tat cca tac cct cgt gcc cct gtt ttt cct ggc
2444Ser Gly Gly Ile Gly Tyr Pro Tyr Pro Arg Ala Pro Val Phe Pro Gly
730 735 740cgt ggt agt tac tca aac
aga ggg aac tac aac aga ggt gga atg ccc 2492Arg Gly Ser Tyr Ser Asn
Arg Gly Asn Tyr Asn Arg Gly Gly Met Pro 745 750
755aac aga ggg aac tac aac cag aac ttc aga gga cga gga aac
aat cgt 2540Asn Arg Gly Asn Tyr Asn Gln Asn Phe Arg Gly Arg Gly Asn
Asn Arg 760 765 770ggc tac aaa aat caa
tct cag ggc tac aac cag tgg cag cag ggt caa 2588Gly Tyr Lys Asn Gln
Ser Gln Gly Tyr Asn Gln Trp Gln Gln Gly Gln775 780
785 790ttc tgg ggt cag aag cca tgg agt cag cat
tat cac caa gga tat tat 2636Phe Trp Gly Gln Lys Pro Trp Ser Gln His
Tyr His Gln Gly Tyr Tyr 795 800
805tga atacccaaat aaaacgaact gatacatatt tctccaaaac cttcacaaga
2689agtcgactgt tttctttagt aggctaactt tttaaacatt ccacaagagg aagtgcctgc
2749gggttccttt tttagaagct ttgtgggttg attttttttc ttttcttttt tgtacatttt
2809taattgcagt ttaaaagtga atcgtaagag aacctcagca ttgtgcacga taagagaatg
2869tgtcagtatt tcagggttct acattttatc tgtaaaatgt gacttttttt tttttttatc
2929acaacagaag taaaatgttg ctttgtacct ggtgtctttt attaagaatt tactcccccc
2989atttctcaca gagaataaca gtcgggagtc attgtcacaa tataatagaa atgttagcaa
3049ccagattcat gtaaggacta agtggtcctc atgaattgca ttaagactct gtactgctca
3109tattacactc catcctctct gtagtttgct gggtagtgga gggggtaagc taaatcatag
3169tttctgacaa taactgggaa ggttttttct taaaataaca atggaattgg tataattggg
3229attgaaaact aaaacttgga actaagatag agaagatgga gtgtatgtag aagggctgtt
3289aaaaatgtaa aacttggttg cattatttgt ggaggctcaa acttgtgaag gttaatacca
3349taatttttcc atttgttctg cattttgatt ctgaaaagaa agctggcttt gcccatttct
3409tattaaaaaa acttgttgta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
346520806PRTHomo sapiens 20Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu
Lys Val Ser Glu Leu1 5 10
15Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala
20 25 30Glu Leu Met Glu Arg Leu Gln
Ala Ala Leu Asp Asp Glu Glu Ala Gly 35 40
45Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly
Gly 50 55 60Asp Ser Ala Gly Arg Ser
Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala65 70
75 80Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu
Glu Glu Glu Gly Ile 85 90
95Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala
100 105 110Ala Gly Ala Ala Asp Ser
Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 115 120
125Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu
Asp Glu 130 135 140Leu Gly Asp Glu Glu
Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu145 150
155 160Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln
Gln Gln Pro Gln Gln Gln 165 170
175Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser
180 185 190Leu Phe Ala Val Thr
Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 195
200 205Gln Ala Gly Gly Asp Gly Lys Thr Glu Gln Lys Gly
Gly Asp Lys Lys 210 215 220Arg Gly Val
Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr Phe Glu225
230 235 240Tyr Ile Glu Glu Asn Lys Tyr
Ser Arg Ala Lys Ser Pro Gln Pro Pro 245
250 255Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val
Val Cys Leu Asp 260 265 270Thr
Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser 275
280 285Ala Ser Ser Leu Thr Met Glu Ser Phe
Ala Phe Leu Trp Ala Gly Gly 290 295
300Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys305
310 315 320Val Thr Glu Lys
Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp 325
330 335Ile His Glu Val Arg Ile Gly Trp Ser Leu
Thr Thr Ser Gly Met Leu 340 345
350Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys
355 360 365Thr Cys Asn Cys Glu Thr Glu
Asp Tyr Gly Glu Lys Phe Asp Glu Asn 370 375
380Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu
Leu385 390 395 400Ser Tyr
Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser
405 410 415Lys Glu Val Leu Ala Gly Arg
Pro Leu Phe Pro His Val Leu Cys His 420 425
430Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro
Tyr Phe 435 440 445Pro Ile Pro Glu
Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp 450
455 460Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys
Asp Cys Glu Val465 470 475
480Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr
485 490 495Lys His Ala Ala Glu
Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn 500
505 510Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys
Lys Gln Met Ala 515 520 525Asp Thr
Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu 530
535 540Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys
Arg Asn Phe Ile Leu545 550 555
560Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu
565 570 575Phe Ala Gly Phe
Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu 580
585 590Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu
Val Glu Gly Lys Asp 595 600 605Leu
Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro 610
615 620Glu Val Ala Glu Cys Phe Asp Glu Ile Thr
Tyr Val Glu Leu Gln Lys625 630 635
640Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys
Lys 645 650 655Ala Leu Pro
Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn 660
665 670Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn
Arg Gly Gly Gly His Arg 675 680
685Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Ala 690
695 700Pro Gly Asn Arg Gly Gly Tyr Asn
Arg Arg Gly Asn Met Pro Gln Arg705 710
715 720Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Gly Tyr
Pro Tyr Pro Arg 725 730
735Ala Pro Val Phe Pro Gly Arg Gly Ser Tyr Ser Asn Arg Gly Asn Tyr
740 745 750Asn Arg Gly Gly Met Pro
Asn Arg Gly Asn Tyr Asn Gln Asn Phe Arg 755 760
765Gly Arg Gly Asn Asn Arg Gly Tyr Lys Asn Gln Ser Gln Gly
Tyr Asn 770 775 780Gln Trp Gln Gln Gly
Gln Phe Trp Gly Gln Lys Pro Trp Ser Gln His785 790
795 800Tyr His Gln Gly Tyr Tyr
805213933DNAHomo sapiensCDS(318)..(2861) 21gcgagagtgg gtttgttctt
gggctgcagc cgctgccgcc gcttctcgcc agcgccgttg 60ctgcggggga ttgtgggagt
ctccgcgtcc cgctcgctgg gagagaggta cctctccttt 120tccctctccc tttccctaag
agttgtctgc tggttctcag cttgaagaag attctgcagt 180ccttattgat cctttttctt
ggcgttacca tttttgaagc aaagttaacc tagctttcta 240gtttgagctt tctttttggc
cgtctttaaa aaaaattttt tttttaatct ataaaataga 300caagagctag ttctaca atg
tcc aag tca ttc cag cag tca tct ctc agt 350 Met
Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser 1
5 10agg gac tca cag ggt cat ggg cgt gac ctg tct gcg gca
gga ata ggc 398Arg Asp Ser Gln Gly His Gly Arg Asp Leu Ser Ala Ala
Gly Ile Gly 15 20 25ctt ctt
gct gct gct acc cag tct tta agt atg cca gca tct ctt gga 446Leu Leu
Ala Ala Ala Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly 30
35 40agg atg aac cag ggt act gca cgc ctt gct
agt tta atg aat ctt gga 494Arg Met Asn Gln Gly Thr Ala Arg Leu Ala
Ser Leu Met Asn Leu Gly 45 50 55atg
agt tct tca ttg aat caa caa gga gct cat agt gca ctg tct tct 542Met
Ser Ser Ser Leu Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser60
65 70 75gct agt act tct tcc cat
aat ttg cag tct ata ttt aac att gga agt 590Ala Ser Thr Ser Ser His
Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser 80
85 90aga ggt cca ctc cct tta tct tct caa cac cgt gga
gat gca gac cag 638Arg Gly Pro Leu Pro Leu Ser Ser Gln His Arg Gly
Asp Ala Asp Gln 95 100 105gcc
agt aac att ttg gcc agc ttt ggt ctg tct gct aga gac tta gat 686Ala
Ser Asn Ile Leu Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp 110
115 120gaa ctg agt cgt tat cca gag gac aag
att act cct gag aat ttg ccc 734Glu Leu Ser Arg Tyr Pro Glu Asp Lys
Ile Thr Pro Glu Asn Leu Pro 125 130
135caa atc ctt cta cag ctt aaa agg agg aga act gaa gaa ggc cct acc
782Gln Ile Leu Leu Gln Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr140
145 150 155ttg agt tat ggt
aga gat ggc aga tct gct aca cgg gag cca cca tac 830Leu Ser Tyr Gly
Arg Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr 160
165 170aga gta cct agg gat gat tgg gaa gaa aaa
agg cac ttt aga aga gat 878Arg Val Pro Arg Asp Asp Trp Glu Glu Lys
Arg His Phe Arg Arg Asp 175 180
185agt ttt gat gat cgt ggt cct agt ctc aac cca gtg ctt gat tat gac
926Ser Phe Asp Asp Arg Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp
190 195 200cat gga agt cgt tct caa gaa
tct ggt tat tat gac aga atg gat tat 974His Gly Ser Arg Ser Gln Glu
Ser Gly Tyr Tyr Asp Arg Met Asp Tyr 205 210
215gaa gat gac aga tta aga gat gga gaa agg tgt agg gat gat tct ttt
1022Glu Asp Asp Arg Leu Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe220
225 230 235ttt ggt gag acc
tcg cat aac tat cat aaa ttt gac agt gag tat gag 1070Phe Gly Glu Thr
Ser His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu 240
245 250aga atg gga cgt ggt cct ggc ccc tta caa
gag aga tct ctc ttt gag 1118Arg Met Gly Arg Gly Pro Gly Pro Leu Gln
Glu Arg Ser Leu Phe Glu 255 260
265aaa aag aga ggc gct cct cca agt agc aat att gaa gac ttc cat gga
1166Lys Lys Arg Gly Ala Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly
270 275 280ctc tta ccg aag ggt tat ccc
cat ctg tgc tct ata tgt gat ttg cca 1214Leu Leu Pro Lys Gly Tyr Pro
His Leu Cys Ser Ile Cys Asp Leu Pro 285 290
295gtt cat tct aat aag gag tgg agt caa cat atc aat gga gca agt cac
1262Val His Ser Asn Lys Glu Trp Ser Gln His Ile Asn Gly Ala Ser His300
305 310 315agt cgt cga tgc
cag ctt ctt ctt gaa atc tac cca gaa tgg aat cct 1310Ser Arg Arg Cys
Gln Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro 320
325 330gac aat gat aca gga cac aca atg ggt gat
cca ttc atg ttg cag cag 1358Asp Asn Asp Thr Gly His Thr Met Gly Asp
Pro Phe Met Leu Gln Gln 335 340
345tct aca aat cca gca cca gga att ctg gga cct cca cct ccc tca ttt
1406Ser Thr Asn Pro Ala Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe
350 355 360cat ctt ggg gga cca gca gtt
gga cca aga gga aat ctg ggt gct gga 1454His Leu Gly Gly Pro Ala Val
Gly Pro Arg Gly Asn Leu Gly Ala Gly 365 370
375aat gga aac ctg caa gga cct aga cac atg cag aaa ggc aga gtg gaa
1502Asn Gly Asn Leu Gln Gly Pro Arg His Met Gln Lys Gly Arg Val Glu380
385 390 395act agc aga gtt
gtt cac atc atg gat ttt caa cga ggg aaa aac ttg 1550Thr Ser Arg Val
Val His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu 400
405 410aga tac cag cta tta cag ctg gta gaa cca
ttt gga gtc att tca aat 1598Arg Tyr Gln Leu Leu Gln Leu Val Glu Pro
Phe Gly Val Ile Ser Asn 415 420
425cat ctg att cta aat aaa att aat gag gca ttt att gaa atg gca acc
1646His Leu Ile Leu Asn Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr
430 435 440aca gag gat gct cag gcc gca
gtg gat tat tac aca acc aca cca gcg 1694Thr Glu Asp Ala Gln Ala Ala
Val Asp Tyr Tyr Thr Thr Thr Pro Ala 445 450
455tta gta ttt ggc aag cca gtg aga gtt cat tta tcc cag aag tat aaa
1742Leu Val Phe Gly Lys Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys460
465 470 475aga ata aag aaa
cct gaa gga aag cca gat cag aag ttt gat caa aag 1790Arg Ile Lys Lys
Pro Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys 480
485 490caa gag ctt gga cgt gtg ata cat ctc agc
aat ttg ccg cat tct ggc 1838Gln Glu Leu Gly Arg Val Ile His Leu Ser
Asn Leu Pro His Ser Gly 495 500
505tat tct gat agt gct gtt ctc aag ctt gct gag cct tat ggg aaa ata
1886Tyr Ser Asp Ser Ala Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile
510 515 520aag aat tac ata ttg atg agg
atg aaa agt cag gct ttt att gag atg 1934Lys Asn Tyr Ile Leu Met Arg
Met Lys Ser Gln Ala Phe Ile Glu Met 525 530
535gag aca aga gaa gat gca atg gca atg gtt gac cat tgt ttg aaa aaa
1982Glu Thr Arg Glu Asp Ala Met Ala Met Val Asp His Cys Leu Lys Lys540
545 550 555gcc ctt tgg ttt
cag ggg aga tgt gtg aag gtt gac ctg tct gag aaa 2030Ala Leu Trp Phe
Gln Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys 560
565 570tat aaa aaa ctg gtt ctg agg att cca aac
aga ggc att gat tta ctg 2078Tyr Lys Lys Leu Val Leu Arg Ile Pro Asn
Arg Gly Ile Asp Leu Leu 575 580
585aaa aaa gat aaa tcc cga aaa aga tct tac tct cca gat ggc aaa gaa
2126Lys Lys Asp Lys Ser Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu
590 595 600tct cca agt gat aag aaa tcc
aaa act gat ggt tcc cag aag act gag 2174Ser Pro Ser Asp Lys Lys Ser
Lys Thr Asp Gly Ser Gln Lys Thr Glu 605 610
615agt tca acc gaa ggt aaa gaa caa gaa gag aag tcc ggt gaa gat ggt
2222Ser Ser Thr Glu Gly Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly620
625 630 635gag aaa gac aca
aag gat gac cag aca gag cag gaa cct aat atg ctt 2270Glu Lys Asp Thr
Lys Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu 640
645 650ctt gaa tct gaa gat gag cta ctt gta gat
gaa gaa gaa gca gca gca 2318Leu Glu Ser Glu Asp Glu Leu Leu Val Asp
Glu Glu Glu Ala Ala Ala 655 660
665ctg cta gaa agt ggc agt tca gtg gga gac gag acc gat ctt gct aat
2366Leu Leu Glu Ser Gly Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn
670 675 680tta ggt gat gtg gct tct gat
ggg aaa aag gaa cca tca gat aaa gct 2414Leu Gly Asp Val Ala Ser Asp
Gly Lys Lys Glu Pro Ser Asp Lys Ala 685 690
695gtg aaa aaa gat gga agt gct tca gca gca gca aag aaa aag ctt aaa
2462Val Lys Lys Asp Gly Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys700
705 710 715aag gtg gac aag
atc gag gaa ctt gat caa gaa aac gaa gca gcg ttg 2510Lys Val Asp Lys
Ile Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu 720
725 730gaa aat gga att aaa aat gag gaa aac aca
gaa cca ggt gct gaa tct 2558Glu Asn Gly Ile Lys Asn Glu Glu Asn Thr
Glu Pro Gly Ala Glu Ser 735 740
745tct gag aac gct gat gat ccc aac aaa gat aca agt gaa aac gca gat
2606Ser Glu Asn Ala Asp Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp
750 755 760ggt caa agt gat gag aac aag
gac gac tat aca atc cca gat gag tat 2654Gly Gln Ser Asp Glu Asn Lys
Asp Asp Tyr Thr Ile Pro Asp Glu Tyr 765 770
775aga att gga cca tat cag ccc aat gtt cct gtt ggt ata gac tat gtg
2702Arg Ile Gly Pro Tyr Gln Pro Asn Val Pro Val Gly Ile Asp Tyr Val780
785 790 795ata cct aaa aca
ggg ttt tac tgt aag ctg tgt tca ctc ttt tat aca 2750Ile Pro Lys Thr
Gly Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr Thr 800
805 810aat gaa gaa gtt gca aag aat act cat tgc
agc agc ctt cct cat tat 2798Asn Glu Glu Val Ala Lys Asn Thr His Cys
Ser Ser Leu Pro His Tyr 815 820
825cag aaa tta aag aaa ttt ctg aat aaa ttg gca gaa gaa cgc aga cag
2846Gln Lys Leu Lys Lys Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg Gln
830 835 840aag aag gaa act taa
gatgtgcaag gagatttaat gatttcaaag aaaataatgg 2901Lys Lys Glu Thr
845ttctttgttt ttaatgttaa ccttttttaa atacaatact gatagttaga agaaaactat
2961tgtactcttt tgttttagtg gagaaataat agatgtctgt tcatgtgtta agtgttatag
3021caaaaaaaat acacatatgg ttaagttaat gaatagtttt tgttttatca gaatggcaac
3081agacagaagt actttgtaga gattgacttc ctaagctact taagacaact tgcaccacta
3141agaaaaaaat gtagaaccat ttggaaaaat gaaatttagt agttccaagt ttcaaagaaa
3201tgtcaacatt ttattccatt caataaagaa caaaaccaat agtgttttta ttactttcat
3261ctgaaacatt ccatgtttta atctgagcct tgcagacttt catttggagt ttgaacccgt
3321tttggttgca tttcattttt ggagaactta attaacgtga gattggcaat tgaaatgcag
3381gtgcagtttt ctgttaatgt catgctgttg tttaggtaat aagaaatatt aagtaattgg
3441ctttagattt tgtaattttt ttccctgagt tcctgctaga tttcgtattc tagtagtcaa
3501tgtattttca gtgaaatgca aaaatattcc cgttatcttt gaccagtatt aatttttgag
3561atcttactgc ttgtcacttg aatcccgtga ttgtcataca tctctggtat aagcaacatt
3621tgatttttga agtgtgtaga ccatctcttc atattttcaa gatgtaattt tacatttctg
3681catttttaaa acagtttggc cataatccta gatgcacgct tctaattcat gtacctgcac
3741atgtgacctt tgtgaacaga aatttgcatg tataatttgt gtttacttgt aactttctgg
3801ttatatactg cttatatctg tggattcaag ttactgaagt gaataccaat aaaaagaaaa
3861ccctaggcca tgttaattgg ttatacatgt ttggaatgtt aaaaaaaaaa aaaaaaaaaa
3921aaaaaaaaaa aa
393322847PRTHomo sapiens 22Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser
Arg Asp Ser Gln Gly1 5 10
15His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala
20 25 30Thr Gln Ser Leu Ser Met Pro
Ala Ser Leu Gly Arg Met Asn Gln Gly 35 40
45Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser
Leu 50 55 60Asn Gln Gln Gly Ala His
Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser65 70
75 80His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser
Arg Gly Pro Leu Pro 85 90
95Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu
100 105 110Ala Ser Phe Gly Leu Ser
Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 115 120
125Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu
Leu Gln 130 135 140Leu Lys Arg Arg Arg
Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg145 150
155 160Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro
Tyr Arg Val Pro Arg Asp 165 170
175Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg
180 185 190Gly Pro Ser Leu Asn
Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 195
200 205Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu
Asp Asp Arg Leu 210 215 220Arg Asp Gly
Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser225
230 235 240His Asn Tyr His Lys Phe Asp
Ser Glu Tyr Glu Arg Met Gly Arg Gly 245
250 255Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys
Lys Arg Gly Ala 260 265 270Pro
Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 275
280 285Tyr Pro His Leu Cys Ser Ile Cys Asp
Leu Pro Val His Ser Asn Lys 290 295
300Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln305
310 315 320Leu Leu Leu Glu
Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 325
330 335His Thr Met Gly Asp Pro Phe Met Leu Gln
Gln Ser Thr Asn Pro Ala 340 345
350Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro
355 360 365Ala Val Gly Pro Arg Gly Asn
Leu Gly Ala Gly Asn Gly Asn Leu Gln 370 375
380Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val
Val385 390 395 400His Ile
Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu
405 410 415Gln Leu Val Glu Pro Phe Gly
Val Ile Ser Asn His Leu Ile Leu Asn 420 425
430Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp
Ala Gln 435 440 445Ala Ala Val Asp
Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 450
455 460Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg
Ile Lys Lys Pro465 470 475
480Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg
485 490 495Val Ile His Leu Ser
Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 500
505 510Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys
Asn Tyr Ile Leu 515 520 525Met Arg
Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 530
535 540Ala Met Ala Met Val Asp His Cys Leu Lys Lys
Ala Leu Trp Phe Gln545 550 555
560Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val
565 570 575Leu Arg Ile Pro
Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 580
585 590Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu
Ser Pro Ser Asp Lys 595 600 605Lys
Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly 610
615 620Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp
Gly Glu Lys Asp Thr Lys625 630 635
640Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu
Asp 645 650 655Glu Leu Leu
Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly 660
665 670Ser Ser Val Gly Asp Glu Thr Asp Leu Ala
Asn Leu Gly Asp Val Ala 675 680
685Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly 690
695 700Ser Ala Ser Ala Ala Ala Lys Lys
Lys Leu Lys Lys Val Asp Lys Ile705 710
715 720Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu
Asn Gly Ile Lys 725 730
735Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp
740 745 750Asp Pro Asn Lys Asp Thr
Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu 755 760
765Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly
Pro Tyr 770 775 780Gln Pro Asn Val Pro
Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly785 790
795 800Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr
Thr Asn Glu Glu Val Ala 805 810
815Lys Asn Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys
820 825 830Phe Leu Asn Lys Leu
Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 835 840
845231339DNAHomo sapiensCDS(47)..(1018) 23gaattccgat
tagtgtgatc tcagctcaag gcaaaggtgg gatatc atg gca tct 55
Met Ala Ser
1atc tgg gtt gga cac cga gga aca gta aga gat
tat cca gac ttt agc 103Ile Trp Val Gly His Arg Gly Thr Val Arg Asp
Tyr Pro Asp Phe Ser 5 10 15cca tca
gtg gat gct gaa gct att cag aaa gca atc aga gga att gga 151Pro Ser
Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg Gly Ile Gly20
25 30 35act gat gag aaa atg ctc atc
agc att ctg act gag agg tca aat gca 199Thr Asp Glu Lys Met Leu Ile
Ser Ile Leu Thr Glu Arg Ser Asn Ala 40 45
50cag cgg cag ctg att gtt aag gaa tat caa gca gca tat
gga aag gag 247Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr
Gly Lys Glu 55 60 65ctg aaa
gat gac ttg aag ggt gat ctc tct ggc cac ttt gag cat ctc 295Leu Lys
Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe Glu His Leu 70
75 80atg gtg gcc cta gtg act cca cca gca gtc
ttt gat gca aag cag cta 343Met Val Ala Leu Val Thr Pro Pro Ala Val
Phe Asp Ala Lys Gln Leu 85 90 95aag
aaa tcc atg aag ggc gcg gga aca aac gaa gat gcc ttg att gaa 391Lys
Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala Leu Ile Glu100
105 110 115atc tta act acc agg aca
agc agg caa atg aag gat atc tct caa gcc 439Ile Leu Thr Thr Arg Thr
Ser Arg Gln Met Lys Asp Ile Ser Gln Ala 120
125 130tat tat aca gta tac aag aag agt ctt gga gat gac
att agt tcc gaa 487Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp
Ile Ser Ser Glu 135 140 145aca
tct ggt gac ttc cgg aaa gct ctg ttg act ttg gca gat ggc aga 535Thr
Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala Asp Gly Arg 150
155 160aga gat gaa agt ctg aaa gtg gat gag
cat ctg gcc aaa caa gat gcc 583Arg Asp Glu Ser Leu Lys Val Asp Glu
His Leu Ala Lys Gln Asp Ala 165 170
175cag att ctc tat aaa gct ggt gag aac aga tgg ggc acg gat gaa gac
631Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr Asp Glu Asp180
185 190 195aaa ttc act gag
atc ctg tgt tta agg agc ttt cct caa tta aaa cta 679Lys Phe Thr Glu
Ile Leu Cys Leu Arg Ser Phe Pro Gln Leu Lys Leu 200
205 210aca ttt gat gaa tac aga aat atc agc caa
aag gac att gtg gac agc 727Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln
Lys Asp Ile Val Asp Ser 215 220
225ata aaa gga gaa tta tct ggg cat ttt gaa gac tta ctg ttg gcc ata
775Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu Leu Ala Ile
230 235 240gtt aat tgt gtg agg aac acg
ccg gcc ttt tta gcc gaa aga ctg cat 823Val Asn Cys Val Arg Asn Thr
Pro Ala Phe Leu Ala Glu Arg Leu His 245 250
255cga gcc ttg aag ggt att gga act gat gag ttt act ctg aac cga ata
871Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu Asn Arg Ile260
265 270 275atg gtg tcc aga
tca gaa att gac ctt ttg gac att cga aca gag ttc 919Met Val Ser Arg
Ser Glu Ile Asp Leu Leu Asp Ile Arg Thr Glu Phe 280
285 290aag aag cat tat ggc tat tcc cta tat tca
gca att aaa tcg gat act 967Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser
Ala Ile Lys Ser Asp Thr 295 300
305tct gga gac tat gaa atc aca ctc tta aaa atc tgt ggt gga gat gac
1015Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly Gly Asp Asp
310 315 320tga accaagaaga taatctccaa
aggtccacga tgggctttcc caacagctcc 1068accttacttc ttctcatact
atttaagaga acaagcaaat ataaacagca acttgtgttc 1128 ctaacaggaa ttttcattgt
tctataacaa caacaacaaa agcgattatt attttagagc 1188atctcattta taatgtagca
gctcataaat gaaattgaaa atggtattaa agatctgcaa 1248ctactatcca acttatattt
ctgctttcaa agttaagaat ctttatagtt ctactccatt 1308aaatataaag caagataata
aaacggaatt c 133924323PRTHomo sapiens
24Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro1
5 10 15Asp Phe Ser Pro Ser Val
Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 20 25
30Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu
Thr Glu Arg 35 40 45Ser Asn Ala
Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 50
55 60Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu
Ser Gly His Phe65 70 75
80Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala
85 90 95Lys Gln Leu Lys Lys Ser
Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 100
105 110Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln
Met Lys Asp Ile 115 120 125Ser Gln
Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 130
135 140Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala
Leu Leu Thr Leu Ala145 150 155
160Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys
165 170 175Gln Asp Ala Gln
Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 180
185 190Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu
Arg Ser Phe Pro Gln 195 200 205Leu
Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 210
215 220Val Asp Ser Ile Lys Gly Glu Leu Ser Gly
His Phe Glu Asp Leu Leu225 230 235
240Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala
Glu 245 250 255Arg Leu His
Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 260
265 270Asn Arg Ile Met Val Ser Arg Ser Glu Ile
Asp Leu Leu Asp Ile Arg 275 280
285Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 290
295 300Ser Asp Thr Ser Gly Asp Tyr Glu
Ile Thr Leu Leu Lys Ile Cys Gly305 310
315 320Gly Asp Asp251659DNAHomo sapiensCDS(152)..(1201)
25gctgggggcg ggtcctgcgg caccgcccgg gaagctgcgc gagggtcgac agcctccgcc
60acatcctcca cctctcttgg tccagcgagc gttgccgggc cagggtcaag cggagggctc
120cgacggcgcg gacggagcga agcgccgagc c atg gcg cac caa acg ggc atc
172 Met Ala His Gln Thr Gly Ile
1 5cac gcc acg gaa gag ctg aag
gaa ttc ttt gcc aag gca cgg gct ggc 220His Ala Thr Glu Glu Leu Lys
Glu Phe Phe Ala Lys Ala Arg Ala Gly 10 15
20tct gtg cgg ctc atc aag gtt gtg att gag gac gag cag ctc gtg
ctg 268Ser Val Arg Leu Ile Lys Val Val Ile Glu Asp Glu Gln Leu Val
Leu 25 30 35ggt gcc tcg cag gag cca
gta ggc cgc tgg gat cag gac tat gac agg 316Gly Ala Ser Gln Glu Pro
Val Gly Arg Trp Asp Gln Asp Tyr Asp Arg40 45
50 55gcc gtg ctg cca ctg ctg gac gcc cag cag ccc
tgc tac ctg ctc tac 364Ala Val Leu Pro Leu Leu Asp Ala Gln Gln Pro
Cys Tyr Leu Leu Tyr 60 65
70cgc ctc gac tca cag aat gct cag ggc ttc gaa tgg ctc ttc ctc gcc
412Arg Leu Asp Ser Gln Asn Ala Gln Gly Phe Glu Trp Leu Phe Leu Ala
75 80 85tgg tcg cct gat aac tcc ccc
gtg cgg ctg aag atg ctg tac gcg gcc 460Trp Ser Pro Asp Asn Ser Pro
Val Arg Leu Lys Met Leu Tyr Ala Ala 90 95
100acg cgg gcc aca gtg aaa aag gag ttt gga ggt ggc cac atc aag
gat 508Thr Arg Ala Thr Val Lys Lys Glu Phe Gly Gly Gly His Ile Lys
Asp 105 110 115gag ctc ttc ggg act gtg
aag gat gac ctc tct ttt gct ggg tac cag 556Glu Leu Phe Gly Thr Val
Lys Asp Asp Leu Ser Phe Ala Gly Tyr Gln120 125
130 135aaa cac ctg tcg tcc tgt gcg gca cct gcc ccg
ctg acc tcg gct gag 604Lys His Leu Ser Ser Cys Ala Ala Pro Ala Pro
Leu Thr Ser Ala Glu 140 145
150aga gag ctc cag cag atc cgc att aac gag gtg aag aca gag atc agt
652Arg Glu Leu Gln Gln Ile Arg Ile Asn Glu Val Lys Thr Glu Ile Ser
155 160 165gtg gaa agc aag cac cag
acc ctg cag ggc ctc gcc ttc ccc ctg cag 700Val Glu Ser Lys His Gln
Thr Leu Gln Gly Leu Ala Phe Pro Leu Gln 170 175
180cct gag gcc cag cgg gca ctc cag cag ctc aag cag aaa atg
gtc aac 748Pro Glu Ala Gln Arg Ala Leu Gln Gln Leu Lys Gln Lys Met
Val Asn 185 190 195tac atc cag atg aag
ctg gac cta gag cgg gaa acc att gag ctg gtg 796Tyr Ile Gln Met Lys
Leu Asp Leu Glu Arg Glu Thr Ile Glu Leu Val200 205
210 215cac aca gag ccc acg gat gtg gcc cag ctg
ccc tcc cgg gtg ccc cga 844His Thr Glu Pro Thr Asp Val Ala Gln Leu
Pro Ser Arg Val Pro Arg 220 225
230gat gct gcc cgc tac cac ttc ttc ctc tac aag cac acc cat gag ggc
892Asp Ala Ala Arg Tyr His Phe Phe Leu Tyr Lys His Thr His Glu Gly
235 240 245gac ccc ctt gag tct gta
gtg ttc atc tac tcc atg ccg ggg tac aag 940Asp Pro Leu Glu Ser Val
Val Phe Ile Tyr Ser Met Pro Gly Tyr Lys 250 255
260tgc agc atc aag gag cga atg ctc tac tcc agc tgc aag agc
cgc ctc 988Cys Ser Ile Lys Glu Arg Met Leu Tyr Ser Ser Cys Lys Ser
Arg Leu 265 270 275ctc gac tcc gtg gag
cag gac ttc cat ctg gag atc gcc aag aaa att 1036Leu Asp Ser Val Glu
Gln Asp Phe His Leu Glu Ile Ala Lys Lys Ile280 285
290 295gag att ggc gat ggg gca gag ctg acg gca
gag ttc ctc tac gac gag 1084Glu Ile Gly Asp Gly Ala Glu Leu Thr Ala
Glu Phe Leu Tyr Asp Glu 300 305
310gtg cac ccc aag caa cac gcc ttc aag cag gcc ttc gcc aag ccc aag
1132Val His Pro Lys Gln His Ala Phe Lys Gln Ala Phe Ala Lys Pro Lys
315 320 325ggc cca ggg ggc aag cgg
ggc cat aag cgc ctc atc cgc ggc ccg ggt 1180Gly Pro Gly Gly Lys Arg
Gly His Lys Arg Leu Ile Arg Gly Pro Gly 330 335
340gaa aat ggg gat gac agc tag gaggctggag cagggccggc
cacgtgtgga 1231Glu Asn Gly Asp Asp Ser 345ctgtggggct gcccaccttc
cgctccctgc caccatcctc cttcctgggc tccaggaaag 1291tgtttctggg aggtcaggag
ggctggcagc tgaacgcact tgcagcgtcc gagggccacc 1351gggctggcat tttgtgaccc
ttccctgttg ctgtccctgc atctcgtctg tgtgcccagg 1411gtgtccgggg accctgcctg
gctggcttaa gggggctggg tcaggggcct ggcatgaacc 1471tggcctcccg gggagctgag
actagggtcc cagcacagcc cagaaacctt tggccacaag 1531aagtggggtc agtcagggct
ggggcagggg tcactgcagt ttgggatggt tgaatgctgt 1591attttctaaa gaataaaata
tttttaaatc aagaaaaaaa aaaaaaaaaa aaaaaaaaaa 1651aaaaaaaa
165926349PRTHomo sapiens
26Met Ala His Gln Thr Gly Ile His Ala Thr Glu Glu Leu Lys Glu Phe1
5 10 15Phe Ala Lys Ala Arg Ala
Gly Ser Val Arg Leu Ile Lys Val Val Ile 20 25
30Glu Asp Glu Gln Leu Val Leu Gly Ala Ser Gln Glu Pro
Val Gly Arg 35 40 45Trp Asp Gln
Asp Tyr Asp Arg Ala Val Leu Pro Leu Leu Asp Ala Gln 50
55 60Gln Pro Cys Tyr Leu Leu Tyr Arg Leu Asp Ser Gln
Asn Ala Gln Gly65 70 75
80Phe Glu Trp Leu Phe Leu Ala Trp Ser Pro Asp Asn Ser Pro Val Arg
85 90 95Leu Lys Met Leu Tyr Ala
Ala Thr Arg Ala Thr Val Lys Lys Glu Phe 100
105 110Gly Gly Gly His Ile Lys Asp Glu Leu Phe Gly Thr
Val Lys Asp Asp 115 120 125Leu Ser
Phe Ala Gly Tyr Gln Lys His Leu Ser Ser Cys Ala Ala Pro 130
135 140Ala Pro Leu Thr Ser Ala Glu Arg Glu Leu Gln
Gln Ile Arg Ile Asn145 150 155
160Glu Val Lys Thr Glu Ile Ser Val Glu Ser Lys His Gln Thr Leu Gln
165 170 175Gly Leu Ala Phe
Pro Leu Gln Pro Glu Ala Gln Arg Ala Leu Gln Gln 180
185 190Leu Lys Gln Lys Met Val Asn Tyr Ile Gln Met
Lys Leu Asp Leu Glu 195 200 205Arg
Glu Thr Ile Glu Leu Val His Thr Glu Pro Thr Asp Val Ala Gln 210
215 220Leu Pro Ser Arg Val Pro Arg Asp Ala Ala
Arg Tyr His Phe Phe Leu225 230 235
240Tyr Lys His Thr His Glu Gly Asp Pro Leu Glu Ser Val Val Phe
Ile 245 250 255Tyr Ser Met
Pro Gly Tyr Lys Cys Ser Ile Lys Glu Arg Met Leu Tyr 260
265 270Ser Ser Cys Lys Ser Arg Leu Leu Asp Ser
Val Glu Gln Asp Phe His 275 280
285Leu Glu Ile Ala Lys Lys Ile Glu Ile Gly Asp Gly Ala Glu Leu Thr 290
295 300Ala Glu Phe Leu Tyr Asp Glu Val
His Pro Lys Gln His Ala Phe Lys305 310
315 320Gln Ala Phe Ala Lys Pro Lys Gly Pro Gly Gly Lys
Arg Gly His Lys 325 330
335Arg Leu Ile Arg Gly Pro Gly Glu Asn Gly Asp Asp Ser 340
345272765DNAHomo sapiensCDS(91)..(837) 27gggagacgtg
gtgccgctgc gggctcgctc tgccgtgcgc taggcttggt gggaaggcct 60gttctcgagt
ccgcgctttt cgtcaccgcc atg tcg gga ggt ggt gtg att cgt 114
Met Ser Gly Gly Gly Val Ile Arg
1 5ggc ccc gca ggg aac aac gat tgc cgc atc tac
gtg ggt aac tta cct 162Gly Pro Ala Gly Asn Asn Asp Cys Arg Ile Tyr
Val Gly Asn Leu Pro 10 15 20cca gac
atc cga acc aag gac att gag gac gtg ttc tac aaa tac ggc 210Pro Asp
Ile Arg Thr Lys Asp Ile Glu Asp Val Phe Tyr Lys Tyr Gly25
30 35 40gct atc cgc gac atc gac ctc
aag aat cgc cgc ggg gga ccg ccc ttc 258Ala Ile Arg Asp Ile Asp Leu
Lys Asn Arg Arg Gly Gly Pro Pro Phe 45 50
55gcc ttc gtt gag ttc gag gac ccg cga gac gcg gaa gac
gcg gtg tat 306Ala Phe Val Glu Phe Glu Asp Pro Arg Asp Ala Glu Asp
Ala Val Tyr 60 65 70ggt cgc
gac ggc tat gat tac gat ggg tac cgt ctg cgg gtg gag ttt 354Gly Arg
Asp Gly Tyr Asp Tyr Asp Gly Tyr Arg Leu Arg Val Glu Phe 75
80 85cct cga agc ggc cgt gga aca ggc cga ggc
ggc ggc ggg ggt gga ggt 402Pro Arg Ser Gly Arg Gly Thr Gly Arg Gly
Gly Gly Gly Gly Gly Gly 90 95 100ggc
gga gct ccc cga ggt cgc tat ggc ccc cca tcc agg cgg tct gaa 450Gly
Gly Ala Pro Arg Gly Arg Tyr Gly Pro Pro Ser Arg Arg Ser Glu105
110 115 120aac aga gtg gtt gtc tct
gga ctg cct cca agt gga agt tgg cag gat 498Asn Arg Val Val Val Ser
Gly Leu Pro Pro Ser Gly Ser Trp Gln Asp 125
130 135tta aag gat cac atg cgt gaa gca ggt gat gta tgt
tat gct gat gtt 546Leu Lys Asp His Met Arg Glu Ala Gly Asp Val Cys
Tyr Ala Asp Val 140 145 150tac
cga gat ggc act ggt gtc gtg gag ttt gta cgg aaa gaa gat atg 594Tyr
Arg Asp Gly Thr Gly Val Val Glu Phe Val Arg Lys Glu Asp Met 155
160 165acc tat gca gtt cga aaa ctg gat aac
act aag ttt aga tct cat gag 642Thr Tyr Ala Val Arg Lys Leu Asp Asn
Thr Lys Phe Arg Ser His Glu 170 175
180gga gaa act gcc tac atc cgg gtt aaa gtt gat ggg ccc aga agt cca
690Gly Glu Thr Ala Tyr Ile Arg Val Lys Val Asp Gly Pro Arg Ser Pro185
190 195 200agt tat gga aga
tct cga tct cga agc cgt agt cgt agc aga agc cgt 738Ser Tyr Gly Arg
Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg 205
210 215agc aga agc aac agc agg agt cgc agt tac
tcc cca agg aga agc aga 786Ser Arg Ser Asn Ser Arg Ser Arg Ser Tyr
Ser Pro Arg Arg Ser Arg 220 225
230gga tca cca cgc tat tct ccc cgt cat agc aga tct cgc tct cgt aca
834Gly Ser Pro Arg Tyr Ser Pro Arg His Ser Arg Ser Arg Ser Arg Thr
235 240 245taa gatgattggt gacacttttt
gtagaaccca tgttgtatac agttttcctt 887tattcagtac aatcttttca
ttttttaatt caaactgttt tgttcagaat gggctaaagt 947 gttgaattgc attcttgtaa
tatccccttg ctcctaacat ctacattccc ttcgtgtctt 1007tgataaattg tattttaagt
gatgtcatag acaggattgt ttaaatttag ttaactccat 1067actcttcaga ctgtgatatt
gtgtaaatgt ctatctgccc tggtttgtgt gaactgggat 1127gttgggggtg tttgtggtta
tcttacctgg ggaagttctt atgtttatct tgcttttcat 1187gtgtctttct gtagacatat
ctgaagagat ggattaagaa tgctttggat taaggattgt 1247ggagcacatt tcaatcattt
taggattgtc aaaaggagga ttgaggagga tcagatcaat 1307aatggaggca atggtatgac
tccaagtgct attgtcacag atgaaattgg cagtattgac 1367cttatactaa aaggcagggg
ttaaaaatga ttatatacat tttccttaaa acacttgcaa 1427acattttatt cagttgtctt
tagctacaat tgctttgctt tttaaacctt ggcaattgtg 1487gcaaaattat attgcccatt
ttgtagcaac ttattttgct cccttccccc catttttgtt 1547ttaataggga ctaatgtggg
aagaactggc taatttgtca cagtgcttag ttacaactgt 1607taatgtgtga cctgctgttg
gtgtacatgt gggtacaggg tgtttttaaa tccaacaaga 1667tagagtataa tatcaatact
gctaaatctg catgtcctct gtgtgactga tagagcgttg 1727ctatttcatt tttttaagac
aaaatgaaag caaaatatag agttccaatg tattggtgta 1787gataatctag ttgggaatac
ttttaagtct caccttcccc tttaaactaa tattcataat 1847tggttcatat gtttaaaaga
ctttaattta caaattaaat tgcaaatggg agcattagat 1907ttagttttag acttaggtgg
gtagcaatgc cagtaaactt aaattacgta acttcttgca 1967accacgaaac ctgtaatacg
ctgtacagta acaagtgttg gcattatcag ttgaactgta 2027aatacaaaat gcttcttcca
attagtctct atgatgatta agtttctaaa atttatctga 2087acaccattca gaaacttgtt
ttggggaatt tgatagttat tgatgtgcat ctgttaaact 2147gatgacagac ataactcatc
attccccaga aacctttttt gattacagta tctaacattt 2207tgcctcctct tttttggttt
tgctggttat aaaggtttgg attggagagg gctcactgga 2267tcccaatcct tggagctgga
tcattggatt caaatcataa tgtggatagg atagggagga 2327tgaattaccc aggattcatg
gagcgggatc agattaccag gaacatagga gtggattcct 2387gccccaacca aaccgcattc
gtgtggattt ttttattcaa cttaattggc tattccaaag 2447attttttttt tcctattttt
gacgattgga gcccttaaga tgcacgatgg aattgtgttt 2507tgcgtttttt ggtaaaagga
gcaaagcgag gacctggaga taaacgctgg agcaatctcc 2567ttggaaggat tcagcacgag
tagatggtaa acatttaaag gggaaagggg gggtttgttt 2627aaaatagtaa atcagtaagt
cacttctaaa tttaaagaaa acaaaattgg agttgaagaa 2687taagtaggtt tccaattggc
tattgccgtt ttctttgaaa aaataaacat tttttaaaaa 2747actaaaaaaa aaaaaaaa
276528248PRTHomo sapiens
28Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys1
5 10 15Arg Ile Tyr Val Gly Asn
Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 20 25
30Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile
Asp Leu Lys 35 40 45Asn Arg Arg
Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 50
55 60Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly
Tyr Asp Tyr Asp65 70 75
80Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly
85 90 95Arg Gly Gly Gly Gly Gly
Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 100
105 110Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val
Val Ser Gly Leu 115 120 125Pro Pro
Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 130
135 140Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp
Gly Thr Gly Val Val145 150 155
160Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp
165 170 175Asn Thr Lys Phe
Arg Ser His Glu Gly Glu Thr Ala Tyr Ile Arg Val 180
185 190Lys Val Asp Gly Pro Arg Ser Pro Ser Tyr Gly
Arg Ser Arg Ser Arg 195 200 205Ser
Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Asn Ser Arg Ser Arg 210
215 220Ser Tyr Ser Pro Arg Arg Ser Arg Gly Ser
Pro Arg Tyr Ser Pro Arg225 230 235
240His Ser Arg Ser Arg Ser Arg Thr
245291167DNAHomo sapiensCDS(73)..(966) 29gccaacttct ccagccggcc ggggcgagcg
ccagcgcggc gtccggggcg agtgacacgc 60agagctgaag cc atg gtt cat cag gtg
ctc tac cgg gcg ctg gtc tcc acc 111 Met Val His Gln Val
Leu Tyr Arg Ala Leu Val Ser Thr 1 5
10aag tgg ctg gcg gag tcc atc agg act ggc aag ctg ggg ccc ggc ctg
159Lys Trp Leu Ala Glu Ser Ile Arg Thr Gly Lys Leu Gly Pro Gly Leu
15 20 25cgg gtg ctg gac gcg tcc tgg tac
tca cca ggc acc cga gag gcc cgc 207Arg Val Leu Asp Ala Ser Trp Tyr
Ser Pro Gly Thr Arg Glu Ala Arg30 35 40
45aag gag tac ctc gag cgc cac gta ccc ggc gcc tct ttc
ttt gac ata 255Lys Glu Tyr Leu Glu Arg His Val Pro Gly Ala Ser Phe
Phe Asp Ile 50 55 60gaa
gag tgc cgg gac acg gcg tcg ccc tac gag atg atg ctg ccc agc 303Glu
Glu Cys Arg Asp Thr Ala Ser Pro Tyr Glu Met Met Leu Pro Ser 65
70 75gag gct ggc ttc gcc gag tat gtg
ggc cgc ctg ggc atc agc aac cac 351Glu Ala Gly Phe Ala Glu Tyr Val
Gly Arg Leu Gly Ile Ser Asn His 80 85
90acg cac gtg gtg gtg tat gat ggt gaa cac ctg ggc agc ttc tat gct
399Thr His Val Val Val Tyr Asp Gly Glu His Leu Gly Ser Phe Tyr Ala
95 100 105ccc cgg gtc tgg tgg atg ttc
cgt gtg ttt ggc cac cgc acc gta tca 447Pro Arg Val Trp Trp Met Phe
Arg Val Phe Gly His Arg Thr Val Ser110 115
120 125gtg ctc aat ggt ggc ttc cgg aac tgg ctg aag gag
ggc cac ccg gtg 495Val Leu Asn Gly Gly Phe Arg Asn Trp Leu Lys Glu
Gly His Pro Val 130 135
140aca tcc gag ccc tca cgc cca gaa ccg gcc gtc ttc aaa gcc aca ctg
543Thr Ser Glu Pro Ser Arg Pro Glu Pro Ala Val Phe Lys Ala Thr Leu
145 150 155gac cgc tcc ctg ctc aag
acc tac gag cag gtg ctg gag aac ctt gaa 591Asp Arg Ser Leu Leu Lys
Thr Tyr Glu Gln Val Leu Glu Asn Leu Glu 160 165
170tct aag agg ttc cag ctg gtg gat tca agg tct caa ggg cgg
ttc ctg 639Ser Lys Arg Phe Gln Leu Val Asp Ser Arg Ser Gln Gly Arg
Phe Leu 175 180 185ggc acc gag ccg gag
ccg gat gca gta gga ctg gac tcg ggc cat atc 687Gly Thr Glu Pro Glu
Pro Asp Ala Val Gly Leu Asp Ser Gly His Ile190 195
200 205cgt ggt gcc gtc aac atg cct ttc atg gac
ttc ctg act gag gat ggc 735Arg Gly Ala Val Asn Met Pro Phe Met Asp
Phe Leu Thr Glu Asp Gly 210 215
220ttc gag aag ggc cca gaa gag ctc cgt gct ctg ttc cag acc aag aag
783Phe Glu Lys Gly Pro Glu Glu Leu Arg Ala Leu Phe Gln Thr Lys Lys
225 230 235gtg gat ctc tcg cag cct
ctc att gcc acg tgc cgc aag gga gtc acc 831Val Asp Leu Ser Gln Pro
Leu Ile Ala Thr Cys Arg Lys Gly Val Thr 240 245
250gcc tgc cac gtg gcc ttg gct gcc tac ctc tgc ggc aag cct
gat gtg 879Ala Cys His Val Ala Leu Ala Ala Tyr Leu Cys Gly Lys Pro
Asp Val 255 260 265gcc gtg tac gat ggc
tcc tgg tcc gag tgg ttt cgc cgg gcc ccc cca 927Ala Val Tyr Asp Gly
Ser Trp Ser Glu Trp Phe Arg Arg Ala Pro Pro270 275
280 285gag agc cgt gtg tcc cag gga aag tct gag
aag gcc tga gccgtgacct 976Glu Ser Arg Val Ser Gln Gly Lys Ser Glu
Lys Ala 290 295cttctgctta ctgtaactgc
ggccggttta gtgaccccat gacttacagc cggttcttac 1036ctcttaggtg aaggagatga
catgttttta gaattgctgt gcaaggctca ccctctctct 1096gtcaacactg gaataaactt
tgccttttct gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1156aaaaaaaaaa a
116730297PRTHomo sapiens
30Met Val His Gln Val Leu Tyr Arg Ala Leu Val Ser Thr Lys Trp Leu1
5 10 15Ala Glu Ser Ile Arg Thr
Gly Lys Leu Gly Pro Gly Leu Arg Val Leu 20 25
30Asp Ala Ser Trp Tyr Ser Pro Gly Thr Arg Glu Ala Arg
Lys Glu Tyr 35 40 45Leu Glu Arg
His Val Pro Gly Ala Ser Phe Phe Asp Ile Glu Glu Cys 50
55 60Arg Asp Thr Ala Ser Pro Tyr Glu Met Met Leu Pro
Ser Glu Ala Gly65 70 75
80Phe Ala Glu Tyr Val Gly Arg Leu Gly Ile Ser Asn His Thr His Val
85 90 95Val Val Tyr Asp Gly Glu
His Leu Gly Ser Phe Tyr Ala Pro Arg Val 100
105 110Trp Trp Met Phe Arg Val Phe Gly His Arg Thr Val
Ser Val Leu Asn 115 120 125Gly Gly
Phe Arg Asn Trp Leu Lys Glu Gly His Pro Val Thr Ser Glu 130
135 140Pro Ser Arg Pro Glu Pro Ala Val Phe Lys Ala
Thr Leu Asp Arg Ser145 150 155
160Leu Leu Lys Thr Tyr Glu Gln Val Leu Glu Asn Leu Glu Ser Lys Arg
165 170 175Phe Gln Leu Val
Asp Ser Arg Ser Gln Gly Arg Phe Leu Gly Thr Glu 180
185 190Pro Glu Pro Asp Ala Val Gly Leu Asp Ser Gly
His Ile Arg Gly Ala 195 200 205Val
Asn Met Pro Phe Met Asp Phe Leu Thr Glu Asp Gly Phe Glu Lys 210
215 220Gly Pro Glu Glu Leu Arg Ala Leu Phe Gln
Thr Lys Lys Val Asp Leu225 230 235
240Ser Gln Pro Leu Ile Ala Thr Cys Arg Lys Gly Val Thr Ala Cys
His 245 250 255Val Ala Leu
Ala Ala Tyr Leu Cys Gly Lys Pro Asp Val Ala Val Tyr 260
265 270Asp Gly Ser Trp Ser Glu Trp Phe Arg Arg
Ala Pro Pro Glu Ser Arg 275 280
285Val Ser Gln Gly Lys Ser Glu Lys Ala 290
295312110DNAHomo sapiensCDS(48)..(1346) 31ctgaggccca gcccccttcg
cccgtttcca tcacgagtgc cgccagc atg tct gac 56
Met Ser Asp
1aaa ctg ccc tac aaa gtc gcc gac atc ggc ctg gct gcc tgg
gga cgc 104Lys Leu Pro Tyr Lys Val Ala Asp Ile Gly Leu Ala Ala Trp
Gly Arg 5 10 15aag gcc ctg gac att
gct gag aac gag atg ccg ggc ctg atg cgt atg 152Lys Ala Leu Asp Ile
Ala Glu Asn Glu Met Pro Gly Leu Met Arg Met20 25
30 35cgg gag cgg tac tcg gcc tcc aag cca ctg
aag ggc gcc cgc atc gct 200Arg Glu Arg Tyr Ser Ala Ser Lys Pro Leu
Lys Gly Ala Arg Ile Ala 40 45
50ggc tgc ctg cac atg acc gtg gag acg gcc gtc ctc att gag acc ctc
248Gly Cys Leu His Met Thr Val Glu Thr Ala Val Leu Ile Glu Thr Leu
55 60 65gtc acc ctg ggt gct gag
gtg cag tgg tcc agc tgc aac atc ttc tcc 296Val Thr Leu Gly Ala Glu
Val Gln Trp Ser Ser Cys Asn Ile Phe Ser 70 75
80acc cag gac cat gcg gcg gct gcc att gcc aag gct ggc att
ccg gtg 344Thr Gln Asp His Ala Ala Ala Ala Ile Ala Lys Ala Gly Ile
Pro Val 85 90 95tat gcc tgg aag ggc
gaa acg gac gag gag tac ctg tgg tgc att gag 392Tyr Ala Trp Lys Gly
Glu Thr Asp Glu Glu Tyr Leu Trp Cys Ile Glu100 105
110 115cag acc ctg tac ttc aag gac ggg ccc ctc
aac atg att ctg gac gac 440Gln Thr Leu Tyr Phe Lys Asp Gly Pro Leu
Asn Met Ile Leu Asp Asp 120 125
130ggg ggc gac ctc acc aac ctc atc cac acc aag tac ccg cag ctt ctg
488Gly Gly Asp Leu Thr Asn Leu Ile His Thr Lys Tyr Pro Gln Leu Leu
135 140 145cca ggc atc cga ggc atc
tct gag gag acc acg act ggg gtc cac aac 536Pro Gly Ile Arg Gly Ile
Ser Glu Glu Thr Thr Thr Gly Val His Asn 150 155
160ctc tac aag atg atg gcc aat ggg atc ctc aag gtg cct gcc
atc aat 584Leu Tyr Lys Met Met Ala Asn Gly Ile Leu Lys Val Pro Ala
Ile Asn 165 170 175gtc aat gac tcc gtc
acc aag agc aag ttt gac aac ctc tat ggc tgc 632Val Asn Asp Ser Val
Thr Lys Ser Lys Phe Asp Asn Leu Tyr Gly Cys180 185
190 195cgg gag tcc ctc ata gat ggc atc aag cgg
gcc aca gat gtg atg att 680Arg Glu Ser Leu Ile Asp Gly Ile Lys Arg
Ala Thr Asp Val Met Ile 200 205
210gcc ggc aag gta gcg gtg gta gca ggc tat ggt gat gtg ggc aag ggc
728Ala Gly Lys Val Ala Val Val Ala Gly Tyr Gly Asp Val Gly Lys Gly
215 220 225tgt gcc cag gcc ctg cgg
ggt ttc gga gcc cgc gtc atc atc acc gag 776Cys Ala Gln Ala Leu Arg
Gly Phe Gly Ala Arg Val Ile Ile Thr Glu 230 235
240att gac ccc atc aac gca ctg cag gct gcc atg gag ggc tat
gag gtg 824Ile Asp Pro Ile Asn Ala Leu Gln Ala Ala Met Glu Gly Tyr
Glu Val 245 250 255acc acc atg gat gag
gcc tgt cag gag ggc aac atc ttt gtc acc acc 872Thr Thr Met Asp Glu
Ala Cys Gln Glu Gly Asn Ile Phe Val Thr Thr260 265
270 275aca ggc tgt att gac atc atc ctt ggc cgg
cac ttt gag cag atg aag 920Thr Gly Cys Ile Asp Ile Ile Leu Gly Arg
His Phe Glu Gln Met Lys 280 285
290gat gat gcc att gtg tgt aac att gga cac ttt gac gtg gag atc gat
968Asp Asp Ala Ile Val Cys Asn Ile Gly His Phe Asp Val Glu Ile Asp
295 300 305gtc aag tgg ctc aac gag
aac gcc gtg gag aag gtg aac atc aag ccg 1016Val Lys Trp Leu Asn Glu
Asn Ala Val Glu Lys Val Asn Ile Lys Pro 310 315
320cag gtg gac cgg tat cgg ttg aag aat ggg cgc cgc atc atc
ctg ctg 1064Gln Val Asp Arg Tyr Arg Leu Lys Asn Gly Arg Arg Ile Ile
Leu Leu 325 330 335gcc gag ggt cgg ctg
gtc aac ctg ggt tgt gcc atg ggc cac ccc agc 1112Ala Glu Gly Arg Leu
Val Asn Leu Gly Cys Ala Met Gly His Pro Ser340 345
350 355ttc gtg atg agt aac tcc ttc acc aac cag
gtg atg gcg cag atc gag 1160Phe Val Met Ser Asn Ser Phe Thr Asn Gln
Val Met Ala Gln Ile Glu 360 365
370ctg tgg acc cat cca gac aag tac ccc gtt ggg gtt cat ttc ctg ccc
1208Leu Trp Thr His Pro Asp Lys Tyr Pro Val Gly Val His Phe Leu Pro
375 380 385aag aag ctg gat gag gca
gtg gct gaa gcc cac ctg ggc aag ctg aat 1256Lys Lys Leu Asp Glu Ala
Val Ala Glu Ala His Leu Gly Lys Leu Asn 390 395
400gtg aag ttg acc aag cta act gag aag caa gcc cag tac ctg
ggc atg 1304Val Lys Leu Thr Lys Leu Thr Glu Lys Gln Ala Gln Tyr Leu
Gly Met 405 410 415tcc tgt gat ggc ccc
ttc aag ccg gat cac tac cgc tac tga 1346Ser Cys Asp Gly Pro
Phe Lys Pro Asp His Tyr Arg Tyr420 425
430gagccaggtc tgcgtttcac cctccagctg ctgtccttgc ccaggcccca cctctcctcc
1406ctaagagcta atggcaccaa ctttgtgact ggtttgtcag tgtcccccat cgactctctg
1466gggctgatca cttagttttt ggcctctgct gcagccgtca tactgttcca aatgtggcag
1526cgggaacaga gtaccctctt caagccccgg tcatgatgga ggtcccagcc acagggaacc
1586atgagctcag tggtcttgga acagctcact aagtcagtcc ttccttagcc tggaagccag
1646tagtggagtc acaaagccca tgtgttttgc catctaggcc ttcacctggt ctgtggactt
1706atacctgtgt gcttggttta caggtccagt ggttcttcag cccatgacag atgagaaggg
1766gctatattga agggcaaaga ggaactgttg tttgaatttt cctgagagcc tggcttagtg
1826ctgggccttc tcttaaacct cattacaatg aggttagtac ttttagtccc tgttttacag
1886gggttagaat agactgttaa ggggcaactg agaaagaaca gagaagtgac agctaggggt
1946tgagaggggc cagaaaaaca tgaatgcagg cagatttcgt gaaatctgcc accactttat
2006aaccagatgg ttcctttcac aaccctgggt caaaaagaga ataatttggc ctataatgtt
2066aaaagaaagc aggaaggtgg gtaaataaaa atcttggtgc ctgg
211032432PRTHomo sapiens 32Met Ser Asp Lys Leu Pro Tyr Lys Val Ala Asp
Ile Gly Leu Ala Ala1 5 10
15Trp Gly Arg Lys Ala Leu Asp Ile Ala Glu Asn Glu Met Pro Gly Leu
20 25 30Met Arg Met Arg Glu Arg Tyr
Ser Ala Ser Lys Pro Leu Lys Gly Ala 35 40
45Arg Ile Ala Gly Cys Leu His Met Thr Val Glu Thr Ala Val Leu
Ile 50 55 60Glu Thr Leu Val Thr Leu
Gly Ala Glu Val Gln Trp Ser Ser Cys Asn65 70
75 80Ile Phe Ser Thr Gln Asp His Ala Ala Ala Ala
Ile Ala Lys Ala Gly 85 90
95Ile Pro Val Tyr Ala Trp Lys Gly Glu Thr Asp Glu Glu Tyr Leu Trp
100 105 110Cys Ile Glu Gln Thr Leu
Tyr Phe Lys Asp Gly Pro Leu Asn Met Ile 115 120
125Leu Asp Asp Gly Gly Asp Leu Thr Asn Leu Ile His Thr Lys
Tyr Pro 130 135 140Gln Leu Leu Pro Gly
Ile Arg Gly Ile Ser Glu Glu Thr Thr Thr Gly145 150
155 160Val His Asn Leu Tyr Lys Met Met Ala Asn
Gly Ile Leu Lys Val Pro 165 170
175Ala Ile Asn Val Asn Asp Ser Val Thr Lys Ser Lys Phe Asp Asn Leu
180 185 190Tyr Gly Cys Arg Glu
Ser Leu Ile Asp Gly Ile Lys Arg Ala Thr Asp 195
200 205Val Met Ile Ala Gly Lys Val Ala Val Val Ala Gly
Tyr Gly Asp Val 210 215 220Gly Lys Gly
Cys Ala Gln Ala Leu Arg Gly Phe Gly Ala Arg Val Ile225
230 235 240Ile Thr Glu Ile Asp Pro Ile
Asn Ala Leu Gln Ala Ala Met Glu Gly 245
250 255Tyr Glu Val Thr Thr Met Asp Glu Ala Cys Gln Glu
Gly Asn Ile Phe 260 265 270Val
Thr Thr Thr Gly Cys Ile Asp Ile Ile Leu Gly Arg His Phe Glu 275
280 285Gln Met Lys Asp Asp Ala Ile Val Cys
Asn Ile Gly His Phe Asp Val 290 295
300Glu Ile Asp Val Lys Trp Leu Asn Glu Asn Ala Val Glu Lys Val Asn305
310 315 320Ile Lys Pro Gln
Val Asp Arg Tyr Arg Leu Lys Asn Gly Arg Arg Ile 325
330 335Ile Leu Leu Ala Glu Gly Arg Leu Val Asn
Leu Gly Cys Ala Met Gly 340 345
350His Pro Ser Phe Val Met Ser Asn Ser Phe Thr Asn Gln Val Met Ala
355 360 365Gln Ile Glu Leu Trp Thr His
Pro Asp Lys Tyr Pro Val Gly Val His 370 375
380Phe Leu Pro Lys Lys Leu Asp Glu Ala Val Ala Glu Ala His Leu
Gly385 390 395 400Lys Leu
Asn Val Lys Leu Thr Lys Leu Thr Glu Lys Gln Ala Gln Tyr
405 410 415Leu Gly Met Ser Cys Asp Gly
Pro Phe Lys Pro Asp His Tyr Arg Tyr 420 425
430331698DNAHomo sapiensCDS(191)..(1309) 33cccggccctc
cctgcacggc ctcccgtgcg cccctgtcag actgtggcgg ccggtcgcgc 60ggtgcgctct
ccctccctgc ccgcagcctg gagaggcgct tcgtgctgca cacccccgcg 120ttcctgccgg
caccgcgcct gccctctgcc gcgctccgcc ctgccgccga ccgcacgccc 180gccgcgggac
atg gca cac gca ccg gca cgc tgc ccc agc gcc cgg ggc 229
Met Ala His Ala Pro Ala Arg Cys Pro Ser Ala Arg Gly 1
5 10tcc ggg gac ggc gag atg ggc aag ccc agg aac gtg
gcg ctc atc acc 277Ser Gly Asp Gly Glu Met Gly Lys Pro Arg Asn Val
Ala Leu Ile Thr 15 20 25ggt atc aca
ggc cag gat ggt tcc tac ctg gct gag ttc ctg ctg gag 325Gly Ile Thr
Gly Gln Asp Gly Ser Tyr Leu Ala Glu Phe Leu Leu Glu30 35
40 45aaa ggc tat gag gtc cat gga att
gta cgg cgg tcc agt tca ttt aat 373Lys Gly Tyr Glu Val His Gly Ile
Val Arg Arg Ser Ser Ser Phe Asn 50 55
60acg ggt cga att gag cat ctg tat aag aat ccc cag gct cac
att gaa 421Thr Gly Arg Ile Glu His Leu Tyr Lys Asn Pro Gln Ala His
Ile Glu 65 70 75gga aac atg
aag ttg cac tat ggc gat ctc act gac agt acc tgc ctt 469Gly Asn Met
Lys Leu His Tyr Gly Asp Leu Thr Asp Ser Thr Cys Leu 80
85 90gtg aag atc att aat gaa gta aag ccc aca gag
atc tac aac ctt gga 517Val Lys Ile Ile Asn Glu Val Lys Pro Thr Glu
Ile Tyr Asn Leu Gly 95 100 105gcc cag
agc cac gtc aaa att tcc ttt gac ctc gct gag tac act gcg 565Ala Gln
Ser His Val Lys Ile Ser Phe Asp Leu Ala Glu Tyr Thr Ala110
115 120 125gac gtt gac gga gtt ggc act
cta cga ctt cta gat gca gtt aag act 613Asp Val Asp Gly Val Gly Thr
Leu Arg Leu Leu Asp Ala Val Lys Thr 130
135 140tgt ggc ctt atc aac tct gtg aag ttc tac caa gcc
tca aca agt gaa 661Cys Gly Leu Ile Asn Ser Val Lys Phe Tyr Gln Ala
Ser Thr Ser Glu 145 150 155ctt
tat ggg aaa gtg cag gaa ata ccc cag aag gag acc acc cct ttc 709Leu
Tyr Gly Lys Val Gln Glu Ile Pro Gln Lys Glu Thr Thr Pro Phe 160
165 170tat ccc cgg tca ccc tat ggg gca gca
aaa ctc tat gcc tat tgg att 757Tyr Pro Arg Ser Pro Tyr Gly Ala Ala
Lys Leu Tyr Ala Tyr Trp Ile 175 180
185gtg gtg aac ttc cgt gag gcg tat aat ctc ttt gca gtg aac ggc att
805Val Val Asn Phe Arg Glu Ala Tyr Asn Leu Phe Ala Val Asn Gly Ile190
195 200 205ctc ttc aat cat
gag agt ccc aga aga gga gct aat ttc gtt act cga 853Leu Phe Asn His
Glu Ser Pro Arg Arg Gly Ala Asn Phe Val Thr Arg 210
215 220aaa att agc cgg tca gta gct aag att tac
ctt gga caa ctg gaa tgt 901Lys Ile Ser Arg Ser Val Ala Lys Ile Tyr
Leu Gly Gln Leu Glu Cys 225 230
235ttc agt ttg gga aat ctg gat gcc aaa cga gat tgg ggc cat gcc aag
949Phe Ser Leu Gly Asn Leu Asp Ala Lys Arg Asp Trp Gly His Ala Lys
240 245 250gac tat gtg gag gct atg tgg
ttg atg ttg cag aat gat gag ccg gag 997Asp Tyr Val Glu Ala Met Trp
Leu Met Leu Gln Asn Asp Glu Pro Glu 255 260
265gac ttc gtt ata gct act ggg gag gtc cat agt gtc cgg gaa ttt gtc
1045Asp Phe Val Ile Ala Thr Gly Glu Val His Ser Val Arg Glu Phe Val270
275 280 285gag aaa tca ttc
ttg cac att gga aaa acc att gtg tgg gaa gga aag 1093Glu Lys Ser Phe
Leu His Ile Gly Lys Thr Ile Val Trp Glu Gly Lys 290
295 300aat gaa aat gaa gtg ggc aga tgt aaa gag
acc ggc aaa gtt cac gtg 1141Asn Glu Asn Glu Val Gly Arg Cys Lys Glu
Thr Gly Lys Val His Val 305 310
315act gtg gat ctc aag tac tac cgg cca act gaa gtg gac ttt ctg cag
1189Thr Val Asp Leu Lys Tyr Tyr Arg Pro Thr Glu Val Asp Phe Leu Gln
320 325 330ggc gac tgc acc aaa gcg aaa
cag aag ctg aac tgg aag ccc cgg gtc 1237Gly Asp Cys Thr Lys Ala Lys
Gln Lys Leu Asn Trp Lys Pro Arg Val 335 340
345gct ttc gat gag ctg gtg agg gag atg gtg cac gcc gac gtg gag ctc
1285Ala Phe Asp Glu Leu Val Arg Glu Met Val His Ala Asp Val Glu Leu350
355 360 365atg agg aca aac
ccc aat gcc tga gcagcgcctc ggagcccggc ccgccctccg 1339Met Arg Thr Asn
Pro Asn Ala 370gctacaatcc ccgcagagtc tccggtgcag acgcgctgcg
gggatgggga gcggcgtgcc 1399aatctgcggg tcccctgcgg cccctgctgc cgctgcgctg
tcccggccgc aagagcgggg 1459ccgccccgcc gaggtttgta gcagccggga tgtgaccctc
cagggtttgg gtcgctttgc 1519gtttgtcgaa gcctcctctg aatggctttg tgaaatcaag
atgttttaat cacattcact 1579ttacttgaaa ttatgttgtt acacaacaaa ttgtggggcc
ttcaaattgt ttttctcttt 1639tcatattaaa aatggtcttt ctgtgaacta gcaaaaaaaa
aaaaaaaaaa aaaaaaaaa 169834372PRTHomo sapiens 34Met Ala His Ala Pro
Ala Arg Cys Pro Ser Ala Arg Gly Ser Gly Asp1 5
10 15Gly Glu Met Gly Lys Pro Arg Asn Val Ala Leu
Ile Thr Gly Ile Thr 20 25
30Gly Gln Asp Gly Ser Tyr Leu Ala Glu Phe Leu Leu Glu Lys Gly Tyr
35 40 45Glu Val His Gly Ile Val Arg Arg
Ser Ser Ser Phe Asn Thr Gly Arg 50 55
60Ile Glu His Leu Tyr Lys Asn Pro Gln Ala His Ile Glu Gly Asn Met65
70 75 80Lys Leu His Tyr Gly
Asp Leu Thr Asp Ser Thr Cys Leu Val Lys Ile 85
90 95Ile Asn Glu Val Lys Pro Thr Glu Ile Tyr Asn
Leu Gly Ala Gln Ser 100 105
110His Val Lys Ile Ser Phe Asp Leu Ala Glu Tyr Thr Ala Asp Val Asp
115 120 125Gly Val Gly Thr Leu Arg Leu
Leu Asp Ala Val Lys Thr Cys Gly Leu 130 135
140Ile Asn Ser Val Lys Phe Tyr Gln Ala Ser Thr Ser Glu Leu Tyr
Gly145 150 155 160Lys Val
Gln Glu Ile Pro Gln Lys Glu Thr Thr Pro Phe Tyr Pro Arg
165 170 175Ser Pro Tyr Gly Ala Ala Lys
Leu Tyr Ala Tyr Trp Ile Val Val Asn 180 185
190Phe Arg Glu Ala Tyr Asn Leu Phe Ala Val Asn Gly Ile Leu
Phe Asn 195 200 205His Glu Ser Pro
Arg Arg Gly Ala Asn Phe Val Thr Arg Lys Ile Ser 210
215 220Arg Ser Val Ala Lys Ile Tyr Leu Gly Gln Leu Glu
Cys Phe Ser Leu225 230 235
240Gly Asn Leu Asp Ala Lys Arg Asp Trp Gly His Ala Lys Asp Tyr Val
245 250 255Glu Ala Met Trp Leu
Met Leu Gln Asn Asp Glu Pro Glu Asp Phe Val 260
265 270Ile Ala Thr Gly Glu Val His Ser Val Arg Glu Phe
Val Glu Lys Ser 275 280 285Phe Leu
His Ile Gly Lys Thr Ile Val Trp Glu Gly Lys Asn Glu Asn 290
295 300Glu Val Gly Arg Cys Lys Glu Thr Gly Lys Val
His Val Thr Val Asp305 310 315
320Leu Lys Tyr Tyr Arg Pro Thr Glu Val Asp Phe Leu Gln Gly Asp Cys
325 330 335Thr Lys Ala Lys
Gln Lys Leu Asn Trp Lys Pro Arg Val Ala Phe Asp 340
345 350Glu Leu Val Arg Glu Met Val His Ala Asp Val
Glu Leu Met Arg Thr 355 360 365Asn
Pro Asn Ala 370352963DNAHomo sapiensCDS(26)..(2317) 35ccactgctgt
cctcttcagc tcaag atg gtg gcc tgc cgg gcg att ggc atc 52
Met Val Ala Cys Arg Ala Ile Gly Ile
1 5ctc agc cgc ttt tct gcc ttc agg atc ctc cgc tcc cga
ggt tat ata 100Leu Ser Arg Phe Ser Ala Phe Arg Ile Leu Arg Ser Arg
Gly Tyr Ile10 15 20
25tgc cgc aat ttt aca ggg tct tct gct ttg ctg acc aga acc cat att
148Cys Arg Asn Phe Thr Gly Ser Ser Ala Leu Leu Thr Arg Thr His Ile
30 35 40aac tat gga gtc aaa ggg
gat gtg gca gtt gtt cga att aac tct ccc 196Asn Tyr Gly Val Lys Gly
Asp Val Ala Val Val Arg Ile Asn Ser Pro 45 50
55aat tca aag gta aat aca ctg agt aaa gag cta cat tca
gag ttc tca 244Asn Ser Lys Val Asn Thr Leu Ser Lys Glu Leu His Ser
Glu Phe Ser 60 65 70gaa gtt atg
aat gaa atc tgg gct agt gat caa atc aga agt gcc gtc 292Glu Val Met
Asn Glu Ile Trp Ala Ser Asp Gln Ile Arg Ser Ala Val 75
80 85ctt atc tca tca aag cca ggc tgc ttt att gca ggt
gct gat atc aac 340Leu Ile Ser Ser Lys Pro Gly Cys Phe Ile Ala Gly
Ala Asp Ile Asn90 95 100
105atg tta gcc gct tgc aag acc ctt caa gaa gta aca cag cta tca caa
388Met Leu Ala Ala Cys Lys Thr Leu Gln Glu Val Thr Gln Leu Ser Gln
110 115 120gaa gca cag aga ata
gtt gag aaa ctt gaa aag tcc aca aag cct att 436Glu Ala Gln Arg Ile
Val Glu Lys Leu Glu Lys Ser Thr Lys Pro Ile 125
130 135gtg gct gcc atc aat gga tcc tgc ctg gga gga gga
ctt gag gtt gcc 484Val Ala Ala Ile Asn Gly Ser Cys Leu Gly Gly Gly
Leu Glu Val Ala 140 145 150att tca
tgc caa tac aga ata gca aca aaa gac aga aaa aca gta tta 532Ile Ser
Cys Gln Tyr Arg Ile Ala Thr Lys Asp Arg Lys Thr Val Leu 155
160 165ggt acc cct gaa gtt ttg ctg ggg gcc tta cca
gga gca gga ggc aca 580Gly Thr Pro Glu Val Leu Leu Gly Ala Leu Pro
Gly Ala Gly Gly Thr170 175 180
185caa agg ctg ccc aaa atg gtg ggt gtg cct gct gct ttg gac atg atg
628Gln Arg Leu Pro Lys Met Val Gly Val Pro Ala Ala Leu Asp Met Met
190 195 200ctg act ggt aga agc
att cgt gca gac agg gca aag aaa atg gga ctg 676Leu Thr Gly Arg Ser
Ile Arg Ala Asp Arg Ala Lys Lys Met Gly Leu 205
210 215gtt gac caa ctg gtg gaa ccc ctg gga cca gga cta
aaa cct cca gag 724Val Asp Gln Leu Val Glu Pro Leu Gly Pro Gly Leu
Lys Pro Pro Glu 220 225 230gaa cgg
aca ata gaa tac cta gaa gaa gtt gca att act ttt gcc aaa 772Glu Arg
Thr Ile Glu Tyr Leu Glu Glu Val Ala Ile Thr Phe Ala Lys 235
240 245gga cta gct gat aag aag atc tct cca aag aga
gac aag gga ttg gtg 820Gly Leu Ala Asp Lys Lys Ile Ser Pro Lys Arg
Asp Lys Gly Leu Val250 255 260
265gaa aaa ttg aca gcg tat gcc atg act att cca ttt gtc agg caa cag
868Glu Lys Leu Thr Ala Tyr Ala Met Thr Ile Pro Phe Val Arg Gln Gln
270 275 280gtt tac aaa aaa gtg
gaa gaa aaa gtg cga aag cag act aaa ggc ctt 916Val Tyr Lys Lys Val
Glu Glu Lys Val Arg Lys Gln Thr Lys Gly Leu 285
290 295tat cct gca cct ctg aaa ata att gat gtg gta aag
act gga att gag 964Tyr Pro Ala Pro Leu Lys Ile Ile Asp Val Val Lys
Thr Gly Ile Glu 300 305 310caa ggg
agt gat gcc ggt tat ctc tgt gaa tct cag aaa ttt gga gag 1012Gln Gly
Ser Asp Ala Gly Tyr Leu Cys Glu Ser Gln Lys Phe Gly Glu 315
320 325ctt gta atg acc aaa gaa tca aag gcc ttg atg
gga ctc tac cat ggt 1060Leu Val Met Thr Lys Glu Ser Lys Ala Leu Met
Gly Leu Tyr His Gly330 335 340
345cag gtc ctg tgc aag aag aat aaa ttt gga gct cca cag aag gat gtt
1108Gln Val Leu Cys Lys Lys Asn Lys Phe Gly Ala Pro Gln Lys Asp Val
350 355 360aag cat ctg gct att
ctt ggt gca ggg ctg atg gga gca ggc atc gcc 1156Lys His Leu Ala Ile
Leu Gly Ala Gly Leu Met Gly Ala Gly Ile Ala 365
370 375caa gtc tcc gtg gat aag ggg cta aag act ata ctt
aaa gat gcc acc 1204Gln Val Ser Val Asp Lys Gly Leu Lys Thr Ile Leu
Lys Asp Ala Thr 380 385 390ctc act
gcg cta gac cga gga cag caa caa gtg ttc aaa gga ttg aat 1252Leu Thr
Ala Leu Asp Arg Gly Gln Gln Gln Val Phe Lys Gly Leu Asn 395
400 405gac aaa gtg aag aag aaa gct cta aca tca ttt
gaa agg gat tcc atc 1300Asp Lys Val Lys Lys Lys Ala Leu Thr Ser Phe
Glu Arg Asp Ser Ile410 415 420
425ttc agc aac ttg act ggg cag ctt gat tac caa ggt ttt gaa aag gcc
1348Phe Ser Asn Leu Thr Gly Gln Leu Asp Tyr Gln Gly Phe Glu Lys Ala
430 435 440gac atg gtg att gaa
gct gtg ttt gag gac ctt agt ctt aag cac aga 1396Asp Met Val Ile Glu
Ala Val Phe Glu Asp Leu Ser Leu Lys His Arg 445
450 455gtg cta aag gaa gta gaa gcg gtg att cca gat cac
tgt atc ttt gcc 1444Val Leu Lys Glu Val Glu Ala Val Ile Pro Asp His
Cys Ile Phe Ala 460 465 470agt aac
aca tct gct ctc cca atc agt gaa atc gct gct gtc agc aaa 1492Ser Asn
Thr Ser Ala Leu Pro Ile Ser Glu Ile Ala Ala Val Ser Lys 475
480 485aga cct gag aag gtg att ggc atg cac tac ttc
tct ccc gtg gac aag 1540Arg Pro Glu Lys Val Ile Gly Met His Tyr Phe
Ser Pro Val Asp Lys490 495 500
505atg cag ctg ctg gag att atc acg acc gag aaa act tcc aaa gac acc
1588Met Gln Leu Leu Glu Ile Ile Thr Thr Glu Lys Thr Ser Lys Asp Thr
510 515 520agt gct tca gct gta
gca gtt ggt ctc aag cag ggg aag gtc atc att 1636Ser Ala Ser Ala Val
Ala Val Gly Leu Lys Gln Gly Lys Val Ile Ile 525
530 535gtg gtt aag gat gga cct ggc ttc tat act acc agg
tgt ctt gcg ccc 1684Val Val Lys Asp Gly Pro Gly Phe Tyr Thr Thr Arg
Cys Leu Ala Pro 540 545 550atg atg
tct gaa gtc atc cga atc ctc cag gaa gga gtt gac ccg aag 1732Met Met
Ser Glu Val Ile Arg Ile Leu Gln Glu Gly Val Asp Pro Lys 555
560 565aag ctg gat tcc ctg acc aca agc ttt ggc ttt
cct gtg ggt gcc gcc 1780Lys Leu Asp Ser Leu Thr Thr Ser Phe Gly Phe
Pro Val Gly Ala Ala570 575 580
585aca ctg gtg gat gaa gtt ggt gtg gat gta gcg aaa cat gtg gcg gaa
1828Thr Leu Val Asp Glu Val Gly Val Asp Val Ala Lys His Val Ala Glu
590 595 600gat ctg ggc aaa gtc
ttt ggg gag cgg ttt gga ggt gga aac cca gaa 1876Asp Leu Gly Lys Val
Phe Gly Glu Arg Phe Gly Gly Gly Asn Pro Glu 605
610 615ctg ctg aca cag atg gtg tcc aag ggc ttc cta ggt
cgt aaa tct ggg 1924Leu Leu Thr Gln Met Val Ser Lys Gly Phe Leu Gly
Arg Lys Ser Gly 620 625 630aag ggc
ttt tac atc tat cag gag ggt gtg aag agg aag gat ttg aat 1972Lys Gly
Phe Tyr Ile Tyr Gln Glu Gly Val Lys Arg Lys Asp Leu Asn 635
640 645tct gac atg gat agt att tta gcg agt ctg aag
ctg cct cct aag tct 2020Ser Asp Met Asp Ser Ile Leu Ala Ser Leu Lys
Leu Pro Pro Lys Ser650 655 660
665gaa gtc tca tca gac gaa gac atc cag ttc cgc ctg gtg aca aga ttt
2068Glu Val Ser Ser Asp Glu Asp Ile Gln Phe Arg Leu Val Thr Arg Phe
670 675 680gtg aat gag gca gtc
atg tgc ctg caa gag ggg atc ttg gcc aca cct 2116Val Asn Glu Ala Val
Met Cys Leu Gln Glu Gly Ile Leu Ala Thr Pro 685
690 695gca gag gga gac atc gga gcc gtc ttt ggg ctt ggc
ttc ccg cct tgt 2164Ala Glu Gly Asp Ile Gly Ala Val Phe Gly Leu Gly
Phe Pro Pro Cys 700 705 710ctg gga
ggg cct ttc cgc ttt gtg gat ctg tat ggc gcc cag aag ata 2212Leu Gly
Gly Pro Phe Arg Phe Val Asp Leu Tyr Gly Ala Gln Lys Ile 715
720 725gtg gac cgg ctc aag aaa tat gaa gct gcc tat
gga aaa cag ttc acc 2260Val Asp Arg Leu Lys Lys Tyr Glu Ala Ala Tyr
Gly Lys Gln Phe Thr730 735 740
745cca tgc cag ctg cta gct gac cat gct aac agc cct aac aag aag ttc
2308Pro Cys Gln Leu Leu Ala Asp His Ala Asn Ser Pro Asn Lys Lys Phe
750 755 760tac cag tga
gcaggcctca tgcctcgctc agtcagtgca ctaaccccag 2357Tyr
Glnctgccggcag tgctggttct ccaacagagt ggtgtctaga tttatcagag taacgagaag
2417acaaactccg gcactgggtt tgctccctga ttaaagtgcc ttcagccaag accatctctc
2477cctcctggtg aagtgtgact tcgaattagt ttgcacttcc tattggaagg tagagcccac
2537tgctcattgt ataagccccg aggcctagag tggcagccaa gagccatctg aagccacctc
2597tctgcctgtt cctcccaaga ggccagggtg gccaggggtg gtgagggcag ttctgcaccc
2657agccaaacac ataacaataa aaaccaaact ctgtgtcagc atctttgccc ttctggttta
2717aacgcctcct tcaaaaagca atctggaaga aagccctgtg ctttggggga gtaagaatgt
2777gtgtgcagaa ttctaggcag caccttaggg agggactggg atgagagaaa gtgggacctg
2837gtgggctcaa ccacacacac ctgtctgtgc agatgctttg cccaggcttc tcaccacggt
2897gtaccgggat attaaacctc tttccccagc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
2957aaaaaa
296336763PRTHomo sapiens 36Met Val Ala Cys Arg Ala Ile Gly Ile Leu Ser
Arg Phe Ser Ala Phe1 5 10
15Arg Ile Leu Arg Ser Arg Gly Tyr Ile Cys Arg Asn Phe Thr Gly Ser
20 25 30Ser Ala Leu Leu Thr Arg Thr
His Ile Asn Tyr Gly Val Lys Gly Asp 35 40
45Val Ala Val Val Arg Ile Asn Ser Pro Asn Ser Lys Val Asn Thr
Leu 50 55 60Ser Lys Glu Leu His Ser
Glu Phe Ser Glu Val Met Asn Glu Ile Trp65 70
75 80Ala Ser Asp Gln Ile Arg Ser Ala Val Leu Ile
Ser Ser Lys Pro Gly 85 90
95Cys Phe Ile Ala Gly Ala Asp Ile Asn Met Leu Ala Ala Cys Lys Thr
100 105 110Leu Gln Glu Val Thr Gln
Leu Ser Gln Glu Ala Gln Arg Ile Val Glu 115 120
125Lys Leu Glu Lys Ser Thr Lys Pro Ile Val Ala Ala Ile Asn
Gly Ser 130 135 140Cys Leu Gly Gly Gly
Leu Glu Val Ala Ile Ser Cys Gln Tyr Arg Ile145 150
155 160Ala Thr Lys Asp Arg Lys Thr Val Leu Gly
Thr Pro Glu Val Leu Leu 165 170
175Gly Ala Leu Pro Gly Ala Gly Gly Thr Gln Arg Leu Pro Lys Met Val
180 185 190Gly Val Pro Ala Ala
Leu Asp Met Met Leu Thr Gly Arg Ser Ile Arg 195
200 205Ala Asp Arg Ala Lys Lys Met Gly Leu Val Asp Gln
Leu Val Glu Pro 210 215 220Leu Gly Pro
Gly Leu Lys Pro Pro Glu Glu Arg Thr Ile Glu Tyr Leu225
230 235 240Glu Glu Val Ala Ile Thr Phe
Ala Lys Gly Leu Ala Asp Lys Lys Ile 245
250 255Ser Pro Lys Arg Asp Lys Gly Leu Val Glu Lys Leu
Thr Ala Tyr Ala 260 265 270Met
Thr Ile Pro Phe Val Arg Gln Gln Val Tyr Lys Lys Val Glu Glu 275
280 285Lys Val Arg Lys Gln Thr Lys Gly Leu
Tyr Pro Ala Pro Leu Lys Ile 290 295
300Ile Asp Val Val Lys Thr Gly Ile Glu Gln Gly Ser Asp Ala Gly Tyr305
310 315 320Leu Cys Glu Ser
Gln Lys Phe Gly Glu Leu Val Met Thr Lys Glu Ser 325
330 335Lys Ala Leu Met Gly Leu Tyr His Gly Gln
Val Leu Cys Lys Lys Asn 340 345
350Lys Phe Gly Ala Pro Gln Lys Asp Val Lys His Leu Ala Ile Leu Gly
355 360 365Ala Gly Leu Met Gly Ala Gly
Ile Ala Gln Val Ser Val Asp Lys Gly 370 375
380Leu Lys Thr Ile Leu Lys Asp Ala Thr Leu Thr Ala Leu Asp Arg
Gly385 390 395 400Gln Gln
Gln Val Phe Lys Gly Leu Asn Asp Lys Val Lys Lys Lys Ala
405 410 415Leu Thr Ser Phe Glu Arg Asp
Ser Ile Phe Ser Asn Leu Thr Gly Gln 420 425
430Leu Asp Tyr Gln Gly Phe Glu Lys Ala Asp Met Val Ile Glu
Ala Val 435 440 445Phe Glu Asp Leu
Ser Leu Lys His Arg Val Leu Lys Glu Val Glu Ala 450
455 460Val Ile Pro Asp His Cys Ile Phe Ala Ser Asn Thr
Ser Ala Leu Pro465 470 475
480Ile Ser Glu Ile Ala Ala Val Ser Lys Arg Pro Glu Lys Val Ile Gly
485 490 495Met His Tyr Phe Ser
Pro Val Asp Lys Met Gln Leu Leu Glu Ile Ile 500
505 510Thr Thr Glu Lys Thr Ser Lys Asp Thr Ser Ala Ser
Ala Val Ala Val 515 520 525Gly Leu
Lys Gln Gly Lys Val Ile Ile Val Val Lys Asp Gly Pro Gly 530
535 540Phe Tyr Thr Thr Arg Cys Leu Ala Pro Met Met
Ser Glu Val Ile Arg545 550 555
560Ile Leu Gln Glu Gly Val Asp Pro Lys Lys Leu Asp Ser Leu Thr Thr
565 570 575Ser Phe Gly Phe
Pro Val Gly Ala Ala Thr Leu Val Asp Glu Val Gly 580
585 590Val Asp Val Ala Lys His Val Ala Glu Asp Leu
Gly Lys Val Phe Gly 595 600 605Glu
Arg Phe Gly Gly Gly Asn Pro Glu Leu Leu Thr Gln Met Val Ser 610
615 620Lys Gly Phe Leu Gly Arg Lys Ser Gly Lys
Gly Phe Tyr Ile Tyr Gln625 630 635
640Glu Gly Val Lys Arg Lys Asp Leu Asn Ser Asp Met Asp Ser Ile
Leu 645 650 655Ala Ser Leu
Lys Leu Pro Pro Lys Ser Glu Val Ser Ser Asp Glu Asp 660
665 670Ile Gln Phe Arg Leu Val Thr Arg Phe Val
Asn Glu Ala Val Met Cys 675 680
685Leu Gln Glu Gly Ile Leu Ala Thr Pro Ala Glu Gly Asp Ile Gly Ala 690
695 700Val Phe Gly Leu Gly Phe Pro Pro
Cys Leu Gly Gly Pro Phe Arg Phe705 710
715 720Val Asp Leu Tyr Gly Ala Gln Lys Ile Val Asp Arg
Leu Lys Lys Tyr 725 730
735Glu Ala Ala Tyr Gly Lys Gln Phe Thr Pro Cys Gln Leu Leu Ala Asp
740 745 750His Ala Asn Ser Pro Asn
Lys Lys Phe Tyr Gln 755 760372438DNAHomo
sapiensCDS(45)..(1571) 37cccggcggcg ccaaccgaag cgccccgcct gatccgtgtc cgac
atg ctg cgc cgc 56
Met Leu Arg Arg 1gct ctg
ctg tgc ctg gcc gtg gcc gcc ctg gtg cgc gcc gac gcc ccc 104Ala Leu
Leu Cys Leu Ala Val Ala Ala Leu Val Arg Ala Asp Ala Pro5
10 15 20gag gag gag gac cac gtc ctg
gtg ctg cgg aaa agc aac ttc gcg gag 152Glu Glu Glu Asp His Val Leu
Val Leu Arg Lys Ser Asn Phe Ala Glu 25 30
35gcg ctg gcg gcc cac aag tac ctg ctg gtg gag ttc tat
gcc cct tgg 200Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe Tyr
Ala Pro Trp 40 45 50tgt ggc
cac tgc aag gct ctg gcc cct gag tat gcc aaa gcc gct ggg 248Cys Gly
His Cys Lys Ala Leu Ala Pro Glu Tyr Ala Lys Ala Ala Gly 55
60 65aag ctg aag gca gaa ggt tcc gag atc agg
ttg gcc aag gtg gac gcc 296Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg
Leu Ala Lys Val Asp Ala 70 75 80acg
gag gag tct gac ctg gcc cag cag tac ggc gtg cgc ggc tat ccc 344Thr
Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val Arg Gly Tyr Pro85
90 95 100acc atc aag ttc ttc agg
aat gga gac acg gct tcc ccc aag gaa tat 392Thr Ile Lys Phe Phe Arg
Asn Gly Asp Thr Ala Ser Pro Lys Glu Tyr 105
110 115aca gct ggc aga gag gct gat gac atc gtg aac tgg
ctg aag aag cgc 440Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp
Leu Lys Lys Arg 120 125 130acg
ggc ccg gct gcc acc acc ctg cct gac ggc gca gct gca gag tcc 488Thr
Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala Ala Ala Glu Ser 135
140 145ttg gtg gag tcc agc gag gtg gct gtc
atc ggc ttc ttc aag gac gtg 536Leu Val Glu Ser Ser Glu Val Ala Val
Ile Gly Phe Phe Lys Asp Val 150 155
160gag tcg gac tct gcc aag cag ttt ttg cag gca gca gag gcc atc gat
584Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala Glu Ala Ile Asp165
170 175 180gac ata cca ttt
ggg atc act tcc aac agt gac gtg ttc tcc aaa tac 632Asp Ile Pro Phe
Gly Ile Thr Ser Asn Ser Asp Val Phe Ser Lys Tyr 185
190 195cag ctc gac aaa gat ggg gtt gtc ctc ttt
aag aag ttt gat gaa ggc 680Gln Leu Asp Lys Asp Gly Val Val Leu Phe
Lys Lys Phe Asp Glu Gly 200 205
210cgg aac aac ttt gaa ggg gag gtc acc aag gag aac ctg ctg gac ttt
728Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn Leu Leu Asp Phe
215 220 225atc aaa cac aac cag ctg ccc
ctt gtc atc gag ttc acc gag cag aca 776Ile Lys His Asn Gln Leu Pro
Leu Val Ile Glu Phe Thr Glu Gln Thr 230 235
240gcc ccg aag att ttt gga ggt gaa atc aag act cac atc ctg ctg ttc
824Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His Ile Leu Leu Phe245
250 255 260ttg ccc aag agt
gtg tct gac tat gac ggc aaa ctg agc aac ttc aaa 872Leu Pro Lys Ser
Val Ser Asp Tyr Asp Gly Lys Leu Ser Asn Phe Lys 265
270 275aca gca gcc gag agc ttc aag ggc aag atc
ctg ttc atc ttc atc gac 920Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile
Leu Phe Ile Phe Ile Asp 280 285
290agc gac cac acc gac aac cag cgc atc ctc gag ttc ttt ggc ctg aag
968Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe Phe Gly Leu Lys
295 300 305aag gaa gag tgc ccg gcc gtg
cgc ctc atc acc ctg gag gag gag atg 1016Lys Glu Glu Cys Pro Ala Val
Arg Leu Ile Thr Leu Glu Glu Glu Met 310 315
320acc aag tac aag ccc gaa tcg gag gag ctg acg gca gag agg atc aca
1064Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala Glu Arg Ile Thr325
330 335 340gag ttc tgc cac
cgc ttc ctg gag ggc aaa atc aag ccc cac ctg atg 1112Glu Phe Cys His
Arg Phe Leu Glu Gly Lys Ile Lys Pro His Leu Met 345
350 355agc cag gag ctg ccg gag gac tgg gac aag
cag cct gtc aag gtg ctt 1160Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys
Gln Pro Val Lys Val Leu 360 365
370gtt ggg aag aac ttt gaa gac gtg gct ttt gat gag aaa aaa aac gtc
1208Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu Lys Lys Asn Val
375 380 385ttt gtg gag ttc tat gcc cca
tgg tgt ggt cac tgc aaa cag ttg gct 1256Phe Val Glu Phe Tyr Ala Pro
Trp Cys Gly His Cys Lys Gln Leu Ala 390 395
400ccc att tgg gat aaa ctg gga gag acg tac aag gac cat gag aac atc
1304Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp His Glu Asn Ile405
410 415 420gtc atc gcc aag
atg gac tcg act gcc aac gag gtg gag gcc gtc aaa 1352Val Ile Ala Lys
Met Asp Ser Thr Ala Asn Glu Val Glu Ala Val Lys 425
430 435gtg cac agc ttc ccc aca ctc aag ttc ttt
cct gcc agt gcc gac agg 1400Val His Ser Phe Pro Thr Leu Lys Phe Phe
Pro Ala Ser Ala Asp Arg 440 445
450acg gtc att gat tac aac ggg gaa cgc acg ctg gat ggt ttt aag aaa
1448Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp Gly Phe Lys Lys
455 460 465ttc ctg gag agc ggt ggc cag
gat ggg gca ggg gat gat gac gat ctc 1496Phe Leu Glu Ser Gly Gly Gln
Asp Gly Ala Gly Asp Asp Asp Asp Leu 470 475
480gag gac ctg gaa gaa gca gag gag cca gac atg gag gaa gac gat gat
1544Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu Glu Asp Asp Asp485
490 495 500cag aaa gct gtg
aaa gat gaa ctg taa tacgcaaagc cagacccggg 1591Gln Lys Ala Val
Lys Asp Glu Leu 505cgctgccgag acccctcggg ggctgcacac
ccagcagcag cgcacgcctc cgaagcctgc 1651ggcctcgctt gaaggagggc gtcgccggaa
acccagggaa cctctctgaa gtgacacctc 1711acccctacac accgtccgtt cacccccgtc
tcttccttct gcttttcggt ttttggaaag 1771ggatccatct ccaggcagcc caccctggtg
gggcttgttt cctgaaacca tgatgtactt 1831tttcatacat gagtctgtcc agagtgcttg
ctaccgtgtt cggagtctcg ctgcctccct 1891cccgcgggag gtttctcctc tttttgaaaa
ttccgtctgt gggattttta gacatttttc 1951gacatcaggg tatttgttcc accttggcca
ggcctcctcg gagaagcttg tcccccgtgt 2011gggagggacg gagccggact ggacatggtc
actcagtacc gcctgcagtg tcgccatgac 2071tgatcatggc tcttgcattt ttgggtaaat
ggagacttcc ggatcctgtc agggtgtccc 2131ccatgcctgg aagaggagct ggtggctgcc
agccctgggg cccggcacag gcctgggcct 2191tccccttccc tcaagccagg gctcctcctc
ctgtcgtggg ctcattgtga ccactggcct 2251ctctacagca cggcctgtgg cctgttcaag
gcagaaccac gacccttgac tcccgggtgg 2311ggaggtggcc aaggatgctg gagctgaatc
agacgctgac agttcttcag gcatttctat 2371ttcacaatcg aattgaacac attggccaaa
taaagttgaa attttaccac caaaaaaaaa 2431aaaaaaa
243838508PRTHomo sapiens 38Met Leu Arg
Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg1 5
10 15Ala Asp Ala Pro Glu Glu Glu Asp His
Val Leu Val Leu Arg Lys Ser 20 25
30Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe
35 40 45Tyr Ala Pro Trp Cys Gly His
Cys Lys Ala Leu Ala Pro Glu Tyr Ala 50 55
60Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala65
70 75 80Lys Val Asp Ala
Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 85
90 95Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg
Asn Gly Asp Thr Ala Ser 100 105
110Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp
115 120 125Leu Lys Lys Arg Thr Gly Pro
Ala Ala Thr Thr Leu Pro Asp Gly Ala 130 135
140Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly
Phe145 150 155 160Phe Lys
Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala
165 170 175Glu Ala Ile Asp Asp Ile Pro
Phe Gly Ile Thr Ser Asn Ser Asp Val 180 185
190Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe
Lys Lys 195 200 205Phe Asp Glu Gly
Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 210
215 220Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu
Val Ile Glu Phe225 230 235
240Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His
245 250 255Ile Leu Leu Phe Leu
Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 260
265 270Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly
Lys Ile Leu Phe 275 280 285Ile Phe
Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 290
295 300Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val
Arg Leu Ile Thr Leu305 310 315
320Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala
325 330 335Glu Arg Ile Thr
Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 340
345 350Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp
Trp Asp Lys Gln Pro 355 360 365Val
Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 370
375 380Lys Lys Asn Val Phe Val Glu Phe Tyr Ala
Pro Trp Cys Gly His Cys385 390 395
400Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys
Asp 405 410 415His Glu Asn
Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 420
425 430Glu Ala Val Lys Val His Ser Phe Pro Thr
Leu Lys Phe Phe Pro Ala 435 440
445Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 450
455 460Gly Phe Lys Lys Phe Leu Glu Ser
Gly Gly Gln Asp Gly Ala Gly Asp465 470
475 480Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu
Pro Asp Met Glu 485 490
495Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 500
50539959DNAHomo sapiensCDS(120)..(764) 39gcagtggagg cggcccaggc
ccgccttccg cagggtgtcg ccgctgtgcc gctagcggtg 60ccccgcctgc tgcggtggca
ccagccagga ggcggagtgg aagtggccgt ggggcgggt 119atg gga cta gct ggc gtg
tgc gcc ctg aga cgc tca gcg ggc tat ata 167Met Gly Leu Ala Gly Val
Cys Ala Leu Arg Arg Ser Ala Gly Tyr Ile1 5
10 15ctc gtc ggt ggg gcc ggc ggt cag tct gcg gca gcg
gca gca aga cgg 215Leu Val Gly Gly Ala Gly Gly Gln Ser Ala Ala Ala
Ala Ala Arg Arg 20 25 30tgc
agt gaa gga gag tgg gcg tct ggc ggg gtc cgc agt ttc agc aga 263Cys
Ser Glu Gly Glu Trp Ala Ser Gly Gly Val Arg Ser Phe Ser Arg 35
40 45gcc gct gca gcc atg gcc cca atc aag
gtg gga gat gcc atc cca gca 311Ala Ala Ala Ala Met Ala Pro Ile Lys
Val Gly Asp Ala Ile Pro Ala 50 55
60gtg gag gtg ttt gaa ggg gag cca ggg aac aag gtg aac ctg gca gag
359Val Glu Val Phe Glu Gly Glu Pro Gly Asn Lys Val Asn Leu Ala Glu65
70 75 80ctg ttc aag ggc aag
aag ggt gtg ctg ttt gga gtt cct ggg gcc ttc 407Leu Phe Lys Gly Lys
Lys Gly Val Leu Phe Gly Val Pro Gly Ala Phe 85
90 95acc cct gga tgt tcc aag aca cac ctg cca ggg
ttt gtg gag cag gct 455Thr Pro Gly Cys Ser Lys Thr His Leu Pro Gly
Phe Val Glu Gln Ala 100 105
110gag gct ctg aag gcc aag gga gtc cag gtg gtg gcc tgt ctg agt gtt
503Glu Ala Leu Lys Ala Lys Gly Val Gln Val Val Ala Cys Leu Ser Val
115 120 125aat gat gcc ttt gtg act ggc
gag tgg ggc cga gcc cac aag gcg gaa 551Asn Asp Ala Phe Val Thr Gly
Glu Trp Gly Arg Ala His Lys Ala Glu 130 135
140ggc aag gtt cgg ctc ctg gct gat ccc act ggg gcc ttt ggg aag gag
599Gly Lys Val Arg Leu Leu Ala Asp Pro Thr Gly Ala Phe Gly Lys Glu145
150 155 160aca gac tta tta
cta gat gat tcg ctg gtg tcc atc ttt ggg aat cga 647Thr Asp Leu Leu
Leu Asp Asp Ser Leu Val Ser Ile Phe Gly Asn Arg 165
170 175cgt ctc aag agg ttc tcc atg gtg gta cag
gat ggc ata gtg aag gcc 695Arg Leu Lys Arg Phe Ser Met Val Val Gln
Asp Gly Ile Val Lys Ala 180 185
190ctg aat gtg gaa cca gat ggc aca ggc ctc acc tgc agc ctg gca ccc
743Leu Asn Val Glu Pro Asp Gly Thr Gly Leu Thr Cys Ser Leu Ala Pro
195 200 205aat atc atc tca cag ctc tga
ggccctgggc cagattactt cctccacccc 794Asn Ile Ile Ser Gln Leu
210tccctatctc acctgcccag ccctgtgctg gggccctgca attggaatgt tggccagatt
854tctgcaataa acacttgtgg tttgcggcca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
914aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
95940214PRTHomo sapiens 40Met Gly Leu Ala Gly Val Cys Ala Leu Arg Arg Ser
Ala Gly Tyr Ile1 5 10
15Leu Val Gly Gly Ala Gly Gly Gln Ser Ala Ala Ala Ala Ala Arg Arg
20 25 30Cys Ser Glu Gly Glu Trp Ala
Ser Gly Gly Val Arg Ser Phe Ser Arg 35 40
45Ala Ala Ala Ala Met Ala Pro Ile Lys Val Gly Asp Ala Ile Pro
Ala 50 55 60Val Glu Val Phe Glu Gly
Glu Pro Gly Asn Lys Val Asn Leu Ala Glu65 70
75 80Leu Phe Lys Gly Lys Lys Gly Val Leu Phe Gly
Val Pro Gly Ala Phe 85 90
95Thr Pro Gly Cys Ser Lys Thr His Leu Pro Gly Phe Val Glu Gln Ala
100 105 110Glu Ala Leu Lys Ala Lys
Gly Val Gln Val Val Ala Cys Leu Ser Val 115 120
125Asn Asp Ala Phe Val Thr Gly Glu Trp Gly Arg Ala His Lys
Ala Glu 130 135 140Gly Lys Val Arg Leu
Leu Ala Asp Pro Thr Gly Ala Phe Gly Lys Glu145 150
155 160Thr Asp Leu Leu Leu Asp Asp Ser Leu Val
Ser Ile Phe Gly Asn Arg 165 170
175Arg Leu Lys Arg Phe Ser Met Val Val Gln Asp Gly Ile Val Lys Ala
180 185 190Leu Asn Val Glu Pro
Asp Gly Thr Gly Leu Thr Cys Ser Leu Ala Pro 195
200 205Asn Ile Ile Ser Gln Leu 210411874DNAHomo
sapiensCDS(7)..(678) 41ccggtg atg gcg gct ggt gat ggg gac gtg aag cta ggc
acc ctg ggg 48 Met Ala Ala Gly Asp Gly Asp Val Lys Leu Gly
Thr Leu Gly 1 5 10agt ggc agc gag
agc agc aac gac ggc ggc agc gag agt cca ggc gac 96Ser Gly Ser Glu
Ser Ser Asn Asp Gly Gly Ser Glu Ser Pro Gly Asp15 20
25 30gcg gga gcg gca gcg gaa ggg gga ggc
tgg gcg gcg gcg gcg ttg gcg 144Ala Gly Ala Ala Ala Glu Gly Gly Gly
Trp Ala Ala Ala Ala Leu Ala 35 40
45ctt ctg acg ggg ggc ggg gaa atg ctg ctg aac gtg gcg ctg gtg
gct 192Leu Leu Thr Gly Gly Gly Glu Met Leu Leu Asn Val Ala Leu Val
Ala 50 55 60ctg gtg ctg ctg
ggg gcc tac cgg ctg tgg gtg cgc tgg ggg cgg cgg 240Leu Val Leu Leu
Gly Ala Tyr Arg Leu Trp Val Arg Trp Gly Arg Arg 65
70 75ggt ctg ggg gcc ggg gcc ggg gcg ggc gag gag agc
ccc gcc acc tct 288Gly Leu Gly Ala Gly Ala Gly Ala Gly Glu Glu Ser
Pro Ala Thr Ser 80 85 90ctg cct cgc
atg aag aag cgg gac ttc agc ttg gag cag ctg cgc cag 336Leu Pro Arg
Met Lys Lys Arg Asp Phe Ser Leu Glu Gln Leu Arg Gln95
100 105 110tac gac ggc tcc cgc aac ccg
cgc atc ctg ctc gcg gtc aat ggg aaa 384Tyr Asp Gly Ser Arg Asn Pro
Arg Ile Leu Leu Ala Val Asn Gly Lys 115
120 125gtc ttc gac gtg acc aaa ggc agc aag ttc tac ggc
ccg gcg ggt cca 432Val Phe Asp Val Thr Lys Gly Ser Lys Phe Tyr Gly
Pro Ala Gly Pro 130 135 140tat
gga ata ttt gct ggt agg gat gcc tcc aga gga ctg gcc aca ttt 480Tyr
Gly Ile Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe 145
150 155tgc cta gat aaa gat gca ctt aga gat
gaa tat gat gat ctc tca gat 528Cys Leu Asp Lys Asp Ala Leu Arg Asp
Glu Tyr Asp Asp Leu Ser Asp 160 165
170ttg aat gca gta caa atg gag agt gtt cga gaa tgg gaa atg cag ttt
576Leu Asn Ala Val Gln Met Glu Ser Val Arg Glu Trp Glu Met Gln Phe175
180 185 190aaa gaa aaa tat
gat tat gta ggc aga ctc cta aaa cca gga gaa gaa 624Lys Glu Lys Tyr
Asp Tyr Val Gly Arg Leu Leu Lys Pro Gly Glu Glu 195
200 205cca tca gaa tat aca gat gaa gaa gat acc
aag gat cac aat aaa cag 672Pro Ser Glu Tyr Thr Asp Glu Glu Asp Thr
Lys Asp His Asn Lys Gln 210 215
220gat tga actttgtaaa caaccaaagt caggggcctt cagaactgca attcttactc
728Aspcctttcacag actgtccgga gtctttgggt ttgattcacc tgctgcgaaa aacattcaac
788aaattgtgta caagataaat taatctcact atgaagattt gaataactag acattattta
848tgctgccaaa ctcatttgtt gcagttgttt gtaatgtcta gtggggcttc atcatcctga
908aaagaaggag acagggattt ttttaaagag caagaaagtc acaatattac ttctttcctt
968ccttttttcc ttctttcctt tcttctttct ctttctttct ttttaaaata tattgaagac
1028aaccagatat gtatttgcta ctcaagtgta cagatctcct caagaaacat caagggactc
1088ctgtgtcaca tactgtgttt ttattttaac atgggtgagg gaggcgacct gatcagggga
1148ggtgggggta cacatcaatt tgagttgttc aggctactga aacattaaaa tgtgaattcc
1208caaacttttc tttttggctt tgtcagggaa aagaaaaata tctttataaa gaaatctttg
1268gaaattagga gaaggaattt caggtgggtt taagtcagag ctagttcccc aacagaaaga
1328tcatttgaaa ccagttttta tcccttctct ttccttccct ttccctaaat caaatcaata
1388ttaattgtgc cttatttcac ttaacataga cttgaattat ttttagggaa agcccctata
1448atgaattcag aaatcactac aagcagcatt aagactgaag ttggaatatt ctgttgacca
1508taaaaccttg atatcattct gtgtatatag aatgtaaaag gaatattaca gtgttaactg
1568ccatatatgt aatatacaca aactcaatta gcattgtaat ggccaaatgc attcccccat
1628gcttttctgt tttcaaaaaa attgaaaaac aaatcaactc ttatccccaa cagctgccta
1688attttaggag tctgaccctc cacatctcac tggtgtgggt gcatggggct gtggagtggg
1748tgtcagtatg gatgtgtctg aatgtgtgag gccttggaag ggactctttc tgcagatact
1808gtaaatacaa gtaccatttt aataaagcat gtacaataaa ccaaaaaaaa aaaaaaaaaa
1868aaaaaa
187442223PRTHomo sapiens 42Met Ala Ala Gly Asp Gly Asp Val Lys Leu Gly
Thr Leu Gly Ser Gly1 5 10
15Ser Glu Ser Ser Asn Asp Gly Gly Ser Glu Ser Pro Gly Asp Ala Gly
20 25 30Ala Ala Ala Glu Gly Gly Gly
Trp Ala Ala Ala Ala Leu Ala Leu Leu 35 40
45Thr Gly Gly Gly Glu Met Leu Leu Asn Val Ala Leu Val Ala Leu
Val 50 55 60Leu Leu Gly Ala Tyr Arg
Leu Trp Val Arg Trp Gly Arg Arg Gly Leu65 70
75 80Gly Ala Gly Ala Gly Ala Gly Glu Glu Ser Pro
Ala Thr Ser Leu Pro 85 90
95Arg Met Lys Lys Arg Asp Phe Ser Leu Glu Gln Leu Arg Gln Tyr Asp
100 105 110Gly Ser Arg Asn Pro Arg
Ile Leu Leu Ala Val Asn Gly Lys Val Phe 115 120
125Asp Val Thr Lys Gly Ser Lys Phe Tyr Gly Pro Ala Gly Pro
Tyr Gly 130 135 140Ile Phe Ala Gly Arg
Asp Ala Ser Arg Gly Leu Ala Thr Phe Cys Leu145 150
155 160Asp Lys Asp Ala Leu Arg Asp Glu Tyr Asp
Asp Leu Ser Asp Leu Asn 165 170
175Ala Val Gln Met Glu Ser Val Arg Glu Trp Glu Met Gln Phe Lys Glu
180 185 190Lys Tyr Asp Tyr Val
Gly Arg Leu Leu Lys Pro Gly Glu Glu Pro Ser 195
200 205Glu Tyr Thr Asp Glu Glu Asp Thr Lys Asp His Asn
Lys Gln Asp 210 215 220433795DNAHomo
sapiensCDS(236)..(1633) 43cagcggcggt ggcccaggta gaggggtccg cgctggcggc
ggcggcggcg ctgttccccg 60cgcggtccgc ggagcggggt ccgggctgcg cgacgtgggg
cggcggcggc actgcggccc 120cggcccaagc ccgaccccgg gtcccctcct cggccgcccc
ccgcccggcc gcccgccctc 180gggcctcccc ccgggccctc ggtcccctcc cccgctggcg
gggcccggac agaag atg 238
Met
1gtg cag aag aaa cca gcc gaa ctt cag ggt ttc cac cgt tcg ttc aag
286Val Gln Lys Lys Pro Ala Glu Leu Gln Gly Phe His Arg Ser Phe Lys
5 10 15ggg cag aac ccc ttc gag
ctg gcc ttc tcc cta gac cag ccc gac cac 334Gly Gln Asn Pro Phe Glu
Leu Ala Phe Ser Leu Asp Gln Pro Asp His 20 25
30gga gac tct gac ttt ggc ctg cag tgc tca gcc cgc cct gac
atg ccc 382Gly Asp Ser Asp Phe Gly Leu Gln Cys Ser Ala Arg Pro Asp
Met Pro 35 40 45gcc agc cag ccc att
gac atc ccg gac gcc aag aag agg ggc aag aag 430Ala Ser Gln Pro Ile
Asp Ile Pro Asp Ala Lys Lys Arg Gly Lys Lys50 55
60 65aag aag cgc ggc cgg gcc acc gac agc ttc
tcg ggc agg ttt gaa gac 478Lys Lys Arg Gly Arg Ala Thr Asp Ser Phe
Ser Gly Arg Phe Glu Asp 70 75
80gtc tac cag ctg cag gaa gat gtg ctg ggg gag ggc gct cat gcc cga
526Val Tyr Gln Leu Gln Glu Asp Val Leu Gly Glu Gly Ala His Ala Arg
85 90 95gtg cag acc tgc atc aac
ctg atc acc agc cag gag tac gcc gtc aag 574Val Gln Thr Cys Ile Asn
Leu Ile Thr Ser Gln Glu Tyr Ala Val Lys 100 105
110atc att gag aag cag cca ggc cac att cgg agc agg gtt ttc
agg gag 622Ile Ile Glu Lys Gln Pro Gly His Ile Arg Ser Arg Val Phe
Arg Glu 115 120 125gtg gag atg ctg tac
cag tgc cag gga cac agg aac gtc cta gag ctg 670Val Glu Met Leu Tyr
Gln Cys Gln Gly His Arg Asn Val Leu Glu Leu130 135
140 145att gag ttc ttc gag gag gag gac cgc ttc
tac ctg gtg ttt gag aag 718Ile Glu Phe Phe Glu Glu Glu Asp Arg Phe
Tyr Leu Val Phe Glu Lys 150 155
160atg cgg gga ggc tcc atc ctg agc cac atc cac aag cgc cgg cac ttc
766Met Arg Gly Gly Ser Ile Leu Ser His Ile His Lys Arg Arg His Phe
165 170 175aac gag ctg gag gcc agc
gtg gtg gtg cag gac gtg gcc agc gcc ttg 814Asn Glu Leu Glu Ala Ser
Val Val Val Gln Asp Val Ala Ser Ala Leu 180 185
190gac ttt ctg cat aac aaa ggc atc gcc cac agg gac cta aag
ccg gaa 862Asp Phe Leu His Asn Lys Gly Ile Ala His Arg Asp Leu Lys
Pro Glu 195 200 205aac atc ctc tgt gag
cac ccc aac cag gtc tcc ccc gtg aag atc tgt 910Asn Ile Leu Cys Glu
His Pro Asn Gln Val Ser Pro Val Lys Ile Cys210 215
220 225gac ttc gac ctg ggc agc ggc atc aaa ctc
aac ggg gac tgc tcc cct 958Asp Phe Asp Leu Gly Ser Gly Ile Lys Leu
Asn Gly Asp Cys Ser Pro 230 235
240atc tcc acc ccg gag ctg ctc act ccg tgc ggc tcg gcg gag tac atg
1006Ile Ser Thr Pro Glu Leu Leu Thr Pro Cys Gly Ser Ala Glu Tyr Met
245 250 255gcc ccg gag gta gtg gag
gcc ttc agc gag gag gct agc atc tac gac 1054Ala Pro Glu Val Val Glu
Ala Phe Ser Glu Glu Ala Ser Ile Tyr Asp 260 265
270aag cgc tgc gac ctg tgg agc ctg ggc gtc atc ttg tat atc
cta ctc 1102Lys Arg Cys Asp Leu Trp Ser Leu Gly Val Ile Leu Tyr Ile
Leu Leu 275 280 285agc ggc tac ccg ccc
ttc gtg ggc cgc tgt ggc agc gac tgc ggc tgg 1150Ser Gly Tyr Pro Pro
Phe Val Gly Arg Cys Gly Ser Asp Cys Gly Trp290 295
300 305gac cgc ggc gag gcc tgc cct gcc tgc cag
aac atg ctg ttt gag agc 1198Asp Arg Gly Glu Ala Cys Pro Ala Cys Gln
Asn Met Leu Phe Glu Ser 310 315
320atc cag gag ggc aag tac gag ttc ccc gac aag gac tgg gcc cac atc
1246Ile Gln Glu Gly Lys Tyr Glu Phe Pro Asp Lys Asp Trp Ala His Ile
325 330 335tcc tgc gct gcc aaa gac
ctc atc tcc aag ctg ctg gtc cgt gac gcc 1294Ser Cys Ala Ala Lys Asp
Leu Ile Ser Lys Leu Leu Val Arg Asp Ala 340 345
350aag cag agg ctg agt gcc gcc caa gtc ctg cag cac ccc tgg
gtt cag 1342Lys Gln Arg Leu Ser Ala Ala Gln Val Leu Gln His Pro Trp
Val Gln 355 360 365ggg tgc gcc ccg gag
aac acc ttg ccc act ccc atg gtc ctg cag agg 1390Gly Cys Ala Pro Glu
Asn Thr Leu Pro Thr Pro Met Val Leu Gln Arg370 375
380 385aac agc tgt gcc aaa gac ctc acg tcc ttc
gcg gct gag gcc att gcc 1438Asn Ser Cys Ala Lys Asp Leu Thr Ser Phe
Ala Ala Glu Ala Ile Ala 390 395
400atg aac cgg cag ctg gcc cag cac gac gag gac ctg gct gag gag gag
1486Met Asn Arg Gln Leu Ala Gln His Asp Glu Asp Leu Ala Glu Glu Glu
405 410 415gcc gcg ggg cag ggc cag
ccc gtc ctg gtc cga gct acc tca cgc tgc 1534Ala Ala Gly Gln Gly Gln
Pro Val Leu Val Arg Ala Thr Ser Arg Cys 420 425
430ctg cag ctg tct cca ccc tcc cag tcc aag ctg gcg cag cgg
cgg caa 1582Leu Gln Leu Ser Pro Pro Ser Gln Ser Lys Leu Ala Gln Arg
Arg Gln 435 440 445agg gcc agt ctg tcc
tcg gcc cca gtg gtc ctg gtg gga gac cac gcc 1630Arg Ala Ser Leu Ser
Ser Ala Pro Val Val Leu Val Gly Asp His Ala450 455
460 465tga ccctcccatc tcccctctgt acataggtca
cccgtccccc aatcaaatct 1683aaaggttttt taagctatcg ccagccggtg
tccagcgggc tgcccctcct ctgcctggat 1743tcccaggcac taagctcagc tgaggggggt
gttttataga aggtttttgc ttttgggttt 1803tttttttcct gtttccaccc ctccccgtta
ttttttcctt tggatggtta aaagcattgc 1863aggcacccgg gaaggtgagc agagggtagg
tgggtgggct tgtcccctcc ccggtccccc 1923gccctgctca cctctactat gaaggtgccc
ccaggtcacc tgtgctgccc gccatctgcc 1983cacgtggctt gcagtgactc aggagagcag
gcccacagcg tttgccatct tgcagagctg 2043gggaggggca caggaccctg ccctcgtgtt
ccctcccagc ccgcagtatt tcagggacag 2103gctcttcccc tctatccctc accctgagag
cacccctggt ggcttggttg gggaagggag 2163gggctgcctg tctctggagg tgtcaggcag
gcaggtggca ggcagctcac ccacccaccc 2223catgggatcc cccagccctt cacccgcgcc
tgccttgtcc ccatgatagt tgacaatcgg 2283ggcttcctgc aaggcccgtc tgtctgtcca
ggactcctgg tggccagatt cggcctccga 2343ccttgacctt aaactgcagc tgaccccagg
ggctcgccgc tgcccctccc ctccacacca 2403aggcctgaga cagcaggagc cccgcctggc
ccgaagccgt ttccaccgca gcaggcagag 2463gggctggaca ggcactgtca gccaatgtgg
ggggtcctga agacaccccc ttggggcacc 2523cgagtgcccc ttctcagggc tcagtctgac
cgtagccacg tcctgcctcg cgccgcccct 2583cgggcctgac ctggaagctc cgtcagctcc
gtccttgtcc ttagagctga gcccagaccc 2643cggggtctgg ccgaatcctc acccccaggg
cagtgttttt ggtctgccac cttcaggaaa 2703acggctgcgg cctcggcctc ccttcgggca
cccaggaatg cgggggtctg ctcagtcccc 2763ccaccctcca tgctccaacc cccgggggct
gcggagcctg ctgccccctc cccgcgggtg 2823gggacgttct atgcaataca gggttccact
ttagaagtgc gcgcggctag ggtcaccgcc 2883cgcccttccc ggcgcagccc ccgagctcca
cagctggggc agcccctctg gcttctaaat 2943ccgcggtcgg gattcttcct cctgtttagt
tttttagttt ttccttaaaa aaaaacaaca 3003catcgatgga ctttgcttcc ctgttcttga
agaatacttg aatgtcgggg ggcctggggg 3063tgggggcctc ggagaccgtc tgcctggccc
tgctgcccct cctgaatctc gtatgatggt 3123cacagtccgg tggccgtggg ggtgctctgc
cttccctggt ccccactgcc catatctgtg 3183gactgcccct tccaaagacc cctggggggg
gtggggcatt ccgcccaccc ctttccccca 3243tcacttctcg cctgtcagtg attccatgtt
tcgtaacggg ggattctctg cctttttgta 3303tcaaagaaca agcaaatgga cccccgcccg
ctgcaggcgc ccatagccat cgggtctcta 3363aagctgagtg gctagcagcg tttgtttgtt
tgtttttttt tttttttctg aaggtgggac 3423agtcacttcc tcctccctcc ccacccctgt
cgcatccacg tgcgacctgg aggactggtc 3483agaaccgtta ctgtgaatga gtgaagatcc
tggaggaccc tgggccccag gccagctccc 3543atcgctgggg gacggtgaac ggccatgtgt
taatgttacg atgtttttaa aagacaaaaa 3603aaaaaaaaaa acctcaaaag tttttttaaa
gtgggggaaa aacatccaag cactttaatt 3663ccaatgtacc aggtgaactg acggagctca
gaagttttcc tttacaccaa ctgtcaatgc 3723cggaattttg tattctgttt tgtaaagatt
taataaaagt caaaaaactt gcaaaaaaaa 3783aaaaaaaaaa aa
379544465PRTHomo sapiens 44Met Val Gln
Lys Lys Pro Ala Glu Leu Gln Gly Phe His Arg Ser Phe1 5
10 15Lys Gly Gln Asn Pro Phe Glu Leu Ala
Phe Ser Leu Asp Gln Pro Asp 20 25
30His Gly Asp Ser Asp Phe Gly Leu Gln Cys Ser Ala Arg Pro Asp Met
35 40 45Pro Ala Ser Gln Pro Ile Asp
Ile Pro Asp Ala Lys Lys Arg Gly Lys 50 55
60Lys Lys Lys Arg Gly Arg Ala Thr Asp Ser Phe Ser Gly Arg Phe Glu65
70 75 80Asp Val Tyr Gln
Leu Gln Glu Asp Val Leu Gly Glu Gly Ala His Ala 85
90 95Arg Val Gln Thr Cys Ile Asn Leu Ile Thr
Ser Gln Glu Tyr Ala Val 100 105
110Lys Ile Ile Glu Lys Gln Pro Gly His Ile Arg Ser Arg Val Phe Arg
115 120 125Glu Val Glu Met Leu Tyr Gln
Cys Gln Gly His Arg Asn Val Leu Glu 130 135
140Leu Ile Glu Phe Phe Glu Glu Glu Asp Arg Phe Tyr Leu Val Phe
Glu145 150 155 160Lys Met
Arg Gly Gly Ser Ile Leu Ser His Ile His Lys Arg Arg His
165 170 175Phe Asn Glu Leu Glu Ala Ser
Val Val Val Gln Asp Val Ala Ser Ala 180 185
190Leu Asp Phe Leu His Asn Lys Gly Ile Ala His Arg Asp Leu
Lys Pro 195 200 205Glu Asn Ile Leu
Cys Glu His Pro Asn Gln Val Ser Pro Val Lys Ile 210
215 220Cys Asp Phe Asp Leu Gly Ser Gly Ile Lys Leu Asn
Gly Asp Cys Ser225 230 235
240Pro Ile Ser Thr Pro Glu Leu Leu Thr Pro Cys Gly Ser Ala Glu Tyr
245 250 255Met Ala Pro Glu Val
Val Glu Ala Phe Ser Glu Glu Ala Ser Ile Tyr 260
265 270Asp Lys Arg Cys Asp Leu Trp Ser Leu Gly Val Ile
Leu Tyr Ile Leu 275 280 285Leu Ser
Gly Tyr Pro Pro Phe Val Gly Arg Cys Gly Ser Asp Cys Gly 290
295 300Trp Asp Arg Gly Glu Ala Cys Pro Ala Cys Gln
Asn Met Leu Phe Glu305 310 315
320Ser Ile Gln Glu Gly Lys Tyr Glu Phe Pro Asp Lys Asp Trp Ala His
325 330 335Ile Ser Cys Ala
Ala Lys Asp Leu Ile Ser Lys Leu Leu Val Arg Asp 340
345 350Ala Lys Gln Arg Leu Ser Ala Ala Gln Val Leu
Gln His Pro Trp Val 355 360 365Gln
Gly Cys Ala Pro Glu Asn Thr Leu Pro Thr Pro Met Val Leu Gln 370
375 380Arg Asn Ser Cys Ala Lys Asp Leu Thr Ser
Phe Ala Ala Glu Ala Ile385 390 395
400Ala Met Asn Arg Gln Leu Ala Gln His Asp Glu Asp Leu Ala Glu
Glu 405 410 415Glu Ala Ala
Gly Gln Gly Gln Pro Val Leu Val Arg Ala Thr Ser Arg 420
425 430Cys Leu Gln Leu Ser Pro Pro Ser Gln Ser
Lys Leu Ala Gln Arg Arg 435 440
445Gln Arg Ala Ser Leu Ser Ser Ala Pro Val Val Leu Val Gly Asp His 450
455 460Ala46545631DNAHomo sapiens
45gaggtgaggg gcgcctctgc ccggccgccc ctactgggaa gtgaggagcc cctctgcctg
60gccagccgcc ccgtccggga gggcggtggg ggggtcagcc cccctcccgg ccagccgccc
120catctgggag gtgaggggca cttctgccgg gccgccccta ctgggaagtg aggagcccct
180ctgcccggcc acgaccccgt ctgggaggtg tgcccagcgg ctcattgggg atgggccatg
240atgacaatgg cggttttgtg gaatagaaag gcgggaaggg tggggaaaaa attgagaaat
300cggatggttg cggggtctgt gtggatagaa gtagacatgg gagacttttc attttgttct
360gtactaagaa aaattcttct gccttgggat cctgttgatc tgtgacctta tccccaaccc
420tgtgctctct gaaacatgtg ctgtgtccac tcagggttaa atggattaag ggcggtgcaa
480gatgtgcttt gttaaacaga tgcttgaagg cagcatgctc gttaagagtc atcaccactc
540cctaatctta agtacccagg gacacaaaca ctgcggaagg ccgcagggtc ctctgcctag
600gaaaaccaga gacctttgtt cacttgttat c
63146472DNAHomo sapiens 46tactgggaag tgaggaaccc ctctgcccgg ccagccgccc
cgtccgggag ggaggtgggg 60ggatcagccc cccgcctggc agccgccccg tccgggaggt
gaggggcgcc tctgcccggc 120cgcccctact gggaagtgag gagcccctct gcccggccag
ccgccccgtc cgggagggag 180gtgggggggt cagccgccgc ccgtccggga cctagctggg
caccgatggg ccggcacggg 240tacggtggca ggaagcgtca ggcgagcgaa gtgcgcgtaa
cagtgccagc gacgacgaga 300cgagcaaagg tagtgccgag tgccagtaca tgatgccatc
ctcagacgat gggaggcggt 360gtcgacgacc cgcgcgctgt actgagcaac agggtacact
aagaatacaa cagtgggtcg 420cagtgcctat gagagaataa gtgatgacgc gtgtcgagcg
attgtaccca ga 472477026DNAHomo sapiensCDS(420)..(5045)
47gacacgcacg cacccgggcg ccgaagggaa agccgcgtct cgccctcccg ccccgccgtc
60ggtcctgtct cagtccctca gcagagcggg aaagcggagg ccggagccgt gacctctgac
120cccgtggtta tgcggagccg ccgcattcct tagcgatcgc ggggcagccg ccgctgccgc
180cgtgggcgac tgacgcagcg cgggcgcgtg gagccgccgc cgcccctccc ccaccgccgc
240tctcgcgcca gccggtcccc gcgtgcccgc cccttctccc cggccgcacc cgagacctcg
300cgcgccgccg ctgccacgcg ccccccccac cgccgccgcc gccccagccc cgcgccaccg
360ccccagcccg cccagcccgg aggtcccgcg tggagctgcc gccgccgccg gggagaagg
419atg aag gac aaa cag aag aag aag aag gag cgc acg tgg gcc gag gcc
467Met Lys Asp Lys Gln Lys Lys Lys Lys Glu Arg Thr Trp Ala Glu Ala1
5 10 15gcg cgc ctg gta tta gaa
aac tac tcg gat gct cca atg aca cca aaa 515Ala Arg Leu Val Leu Glu
Asn Tyr Ser Asp Ala Pro Met Thr Pro Lys 20 25
30cag att ctg cag gtc ata gag gca gaa gga cta aag gaa
atg aga agt 563Gln Ile Leu Gln Val Ile Glu Ala Glu Gly Leu Lys Glu
Met Arg Ser 35 40 45ggg act tcc
cct ctc gca tgc ctc aat gct atg cta cat tcc aat tca 611Gly Thr Ser
Pro Leu Ala Cys Leu Asn Ala Met Leu His Ser Asn Ser 50
55 60aga gga gga gag ggg ttg ttt tat aaa ctg cct ggc
cga atc agc ctt 659Arg Gly Gly Glu Gly Leu Phe Tyr Lys Leu Pro Gly
Arg Ile Ser Leu65 70 75
80ttc acg ctc aag aag gat gcc ctg cag tgg tct cgc cat cca gct aca
707Phe Thr Leu Lys Lys Asp Ala Leu Gln Trp Ser Arg His Pro Ala Thr
85 90 95gtg gag gga gag gag cca
gag gac acg gct gat gtg gag agc tgt ggg 755Val Glu Gly Glu Glu Pro
Glu Asp Thr Ala Asp Val Glu Ser Cys Gly 100
105 110tct aat gaa gcc agc act gtg agt ggt gaa aac gat
gta tct ctt gat 803Ser Asn Glu Ala Ser Thr Val Ser Gly Glu Asn Asp
Val Ser Leu Asp 115 120 125gaa aca
tct tcg aac gca tcc tgt tct aca gaa tct cag agt cga cct 851Glu Thr
Ser Ser Asn Ala Ser Cys Ser Thr Glu Ser Gln Ser Arg Pro 130
135 140ctt tcc aat ccc agg gac agc tac aga gct tcc
tca cag gcg aac aaa 899Leu Ser Asn Pro Arg Asp Ser Tyr Arg Ala Ser
Ser Gln Ala Asn Lys145 150 155
160caa aag aaa aag act ggg gtg atg ctg cct cga gtt gtc ctg act cct
947Gln Lys Lys Lys Thr Gly Val Met Leu Pro Arg Val Val Leu Thr Pro
165 170 175ctg aag gta aac ggg
gcc cac gtg gaa tct gca tca ggg ttc tcg ggc 995Leu Lys Val Asn Gly
Ala His Val Glu Ser Ala Ser Gly Phe Ser Gly 180
185 190tgc cac gcc gat ggc gag agc ggc agc ccg tcc agc
agc agc agc ggc 1043Cys His Ala Asp Gly Glu Ser Gly Ser Pro Ser Ser
Ser Ser Ser Gly 195 200 205tct ctg
gcc ctg ggc agc gct gct att cgt ggc cag gcc gag gtc acc 1091Ser Leu
Ala Leu Gly Ser Ala Ala Ile Arg Gly Gln Ala Glu Val Thr 210
215 220cag gac cct gcc ccg ctc ctg aga ggc ttc cgg
aag cca gcc aca ggt 1139Gln Asp Pro Ala Pro Leu Leu Arg Gly Phe Arg
Lys Pro Ala Thr Gly225 230 235
240caa atg aag cgc aac aga ggg gaa gaa ata gat ttt gag aca cct ggg
1187Gln Met Lys Arg Asn Arg Gly Glu Glu Ile Asp Phe Glu Thr Pro Gly
245 250 255tcc att ctt gtc aac
acc aac ctc cgt gcc ctg atc aac tct cgg acc 1235Ser Ile Leu Val Asn
Thr Asn Leu Arg Ala Leu Ile Asn Ser Arg Thr 260
265 270ttc cat gcc tta cca tca cac ttc cag cag cag ctc
ctc ttc ctc ctg 1283Phe His Ala Leu Pro Ser His Phe Gln Gln Gln Leu
Leu Phe Leu Leu 275 280 285cct gaa
gta gac aga cag gtg ggg acg gat ggc ctg ttg cgt ctc agc 1331Pro Glu
Val Asp Arg Gln Val Gly Thr Asp Gly Leu Leu Arg Leu Ser 290
295 300agc agt gca cta aat aac gag ttt ttt acc cat
gcg gct cag agc tgg 1379Ser Ser Ala Leu Asn Asn Glu Phe Phe Thr His
Ala Ala Gln Ser Trp305 310 315
320cgg gag cgc ctg gct gat ggt gaa ttt act cat gag atg caa gtc agg
1427Arg Glu Arg Leu Ala Asp Gly Glu Phe Thr His Glu Met Gln Val Arg
325 330 335ata cga cag gaa atg
gag aag gaa aag aag gtg gaa caa tgg aaa gaa 1475Ile Arg Gln Glu Met
Glu Lys Glu Lys Lys Val Glu Gln Trp Lys Glu 340
345 350aag ttc ttt gaa gac tac tat gga cag aag ctg ggt
ttg acc aaa gaa 1523Lys Phe Phe Glu Asp Tyr Tyr Gly Gln Lys Leu Gly
Leu Thr Lys Glu 355 360 365gag tca
ttg cag cag aac gtg ggc cag gag gag gct gaa atc aaa agt 1571Glu Ser
Leu Gln Gln Asn Val Gly Gln Glu Glu Ala Glu Ile Lys Ser 370
375 380ggc ttg tgt gtc cca gga gaa tca gtg cgt ata
cag cgt ggt cca gcc 1619Gly Leu Cys Val Pro Gly Glu Ser Val Arg Ile
Gln Arg Gly Pro Ala385 390 395
400acc cga cag cga gat ggg cat ttt aag aaa cgc tct cgg cca gat ctc
1667Thr Arg Gln Arg Asp Gly His Phe Lys Lys Arg Ser Arg Pro Asp Leu
405 410 415cga acc aga gcc aga
agg aat ctg tac aaa aaa cag gag tca gaa caa 1715Arg Thr Arg Ala Arg
Arg Asn Leu Tyr Lys Lys Gln Glu Ser Glu Gln 420
425 430gca ggg gtt gct aag gat gca aaa tct gtg gcc tca
gat gtt ccc ctc 1763Ala Gly Val Ala Lys Asp Ala Lys Ser Val Ala Ser
Asp Val Pro Leu 435 440 445tac aag
gat ggg gag gct aag act gac cca gca ggg ctg agc agt ccc 1811Tyr Lys
Asp Gly Glu Ala Lys Thr Asp Pro Ala Gly Leu Ser Ser Pro 450
455 460cat ctg cca ggc aca tcc tct gca gca ccc gac
ctg gag ggt ccc gaa 1859His Leu Pro Gly Thr Ser Ser Ala Ala Pro Asp
Leu Glu Gly Pro Glu465 470 475
480ttc cca gtt gag tct gtg gct tct cgg atc cag gct gag cca gac aac
1907Phe Pro Val Glu Ser Val Ala Ser Arg Ile Gln Ala Glu Pro Asp Asn
485 490 495ttg gca cgt gcc tct
gca tct cca gac aga att cct agc ctg cct cag 1955Leu Ala Arg Ala Ser
Ala Ser Pro Asp Arg Ile Pro Ser Leu Pro Gln 500
505 510gaa act gtg gat cag gaa ccc aag gat cag aag agg
aaa tcc ttt gag 2003Glu Thr Val Asp Gln Glu Pro Lys Asp Gln Lys Arg
Lys Ser Phe Glu 515 520 525cag gcg
gcc tct gca tcc ttt ccc gaa aag aag ccc cgg ctt gaa gat 2051Gln Ala
Ala Ser Ala Ser Phe Pro Glu Lys Lys Pro Arg Leu Glu Asp 530
535 540cgt cag tcc ttt cgt aac aca att gaa agt gtt
cac acc gaa aag cca 2099Arg Gln Ser Phe Arg Asn Thr Ile Glu Ser Val
His Thr Glu Lys Pro545 550 555
560cag ccc act aaa gag gag ccc aaa gtc ccg ccc atc cgg att caa ctt
2147Gln Pro Thr Lys Glu Glu Pro Lys Val Pro Pro Ile Arg Ile Gln Leu
565 570 575tca cgt atc aaa cca
ccc tgg gtg gtt aaa ggt cag ccc act tac cag 2195Ser Arg Ile Lys Pro
Pro Trp Val Val Lys Gly Gln Pro Thr Tyr Gln 580
585 590ata tgc ccc cgg atc atc ccc acc acg gag tcc tcc
tgc cgg ggt tgg 2243Ile Cys Pro Arg Ile Ile Pro Thr Thr Glu Ser Ser
Cys Arg Gly Trp 595 600 605act ggc
gcc agg acc ctc gca gac att aaa gcc cgt gct ctg cag gtc 2291Thr Gly
Ala Arg Thr Leu Ala Asp Ile Lys Ala Arg Ala Leu Gln Val 610
615 620cga ggg gcg aga ggt cac cac tgc cat aga gag
gcg gcc acc act gcc 2339Arg Gly Ala Arg Gly His His Cys His Arg Glu
Ala Ala Thr Thr Ala625 630 635
640atc gga ggg ggg ggt ggc ccg ggt gga ggt ggc ggc ggg gcc acc gat
2387Ile Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Ala Thr Asp
645 650 655gag gga ggt ggc aga
ggc agc agc agt ggt gat ggt ggt gag gcc tgt 2435Glu Gly Gly Gly Arg
Gly Ser Ser Ser Gly Asp Gly Gly Glu Ala Cys 660
665 670ggc cac cct gag ccc agg gga ggc ccg agc acc cct
gga aag tgt acg 2483Gly His Pro Glu Pro Arg Gly Gly Pro Ser Thr Pro
Gly Lys Cys Thr 675 680 685tca gat
cta cag cga aca caa cta ctg ccg cct tat cct cta aat ggg 2531Ser Asp
Leu Gln Arg Thr Gln Leu Leu Pro Pro Tyr Pro Leu Asn Gly 690
695 700gag cat acc cag gcc gga act gcc atg tcc aga
gct agg aga gag gac 2579Glu His Thr Gln Ala Gly Thr Ala Met Ser Arg
Ala Arg Arg Glu Asp705 710 715
720ctg cct tct ctg aga aag gag gaa agc tgc cta cta cag agg gct aca
2627Leu Pro Ser Leu Arg Lys Glu Glu Ser Cys Leu Leu Gln Arg Ala Thr
725 730 735gtt gga ctc aca gat
ggg cta gga gat gcc tcc caa ctc ccc gtt gct 2675Val Gly Leu Thr Asp
Gly Leu Gly Asp Ala Ser Gln Leu Pro Val Ala 740
745 750ccc act ggg gac cag cca tgc cag gcc ttg ccc cta
ctg tcc tcc caa 2723Pro Thr Gly Asp Gln Pro Cys Gln Ala Leu Pro Leu
Leu Ser Ser Gln 755 760 765acc tca
gta gct gag aga tta gtg gag cag cct cag ttg cat ccg gat 2771Thr Ser
Val Ala Glu Arg Leu Val Glu Gln Pro Gln Leu His Pro Asp 770
775 780gtt aga act gaa tgt gag tct ggc acc act tcc
tgg gaa agt gat gat 2819Val Arg Thr Glu Cys Glu Ser Gly Thr Thr Ser
Trp Glu Ser Asp Asp785 790 795
800gag gag caa gga ccc acc gtt cct gca gac aat ggt ccc att ccg tct
2867Glu Glu Gln Gly Pro Thr Val Pro Ala Asp Asn Gly Pro Ile Pro Ser
805 810 815cta gtg gga gat gat
aca tta gag aaa gga act ggc caa gct ctt gac 2915Leu Val Gly Asp Asp
Thr Leu Glu Lys Gly Thr Gly Gln Ala Leu Asp 820
825 830agt cat ccc act atg aag gat cct gta aat gtg acc
ccc agt tcc aca 2963Ser His Pro Thr Met Lys Asp Pro Val Asn Val Thr
Pro Ser Ser Thr 835 840 845cct gaa
tcc tca ccg act gat tgc ctg cag aac aga gca ttt gat gac 3011Pro Glu
Ser Ser Pro Thr Asp Cys Leu Gln Asn Arg Ala Phe Asp Asp 850
855 860gaa tta ggg ctt ggt ggc tca tgc cct cct atg
agg gaa agt gat act 3059Glu Leu Gly Leu Gly Gly Ser Cys Pro Pro Met
Arg Glu Ser Asp Thr865 870 875
880aga caa gaa aac ttg aaa acc aag gct ctc gtt tct aac agt tct ttg
3107Arg Gln Glu Asn Leu Lys Thr Lys Ala Leu Val Ser Asn Ser Ser Leu
885 890 895cat tgg ata ccc atc
cca tcg aat gat gag gta gtg aaa cag ccc aaa 3155His Trp Ile Pro Ile
Pro Ser Asn Asp Glu Val Val Lys Gln Pro Lys 900
905 910cca gaa tcc aga gaa cac ata cca tct gtt gag ccc
cag gtt gga gag 3203Pro Glu Ser Arg Glu His Ile Pro Ser Val Glu Pro
Gln Val Gly Glu 915 920 925gag tgg
gag aaa gct gct ccc acc cct cct gca ttg cct ggg gat ttg 3251Glu Trp
Glu Lys Ala Ala Pro Thr Pro Pro Ala Leu Pro Gly Asp Leu 930
935 940aca gct gag gag ggt cta gat cct ctt gac agc
ctt act tca ctc tgg 3299Thr Ala Glu Glu Gly Leu Asp Pro Leu Asp Ser
Leu Thr Ser Leu Trp945 950 955
960act gtg cca tct cga gga ggc agt gac agc aat ggc agt tac tgt caa
3347Thr Val Pro Ser Arg Gly Gly Ser Asp Ser Asn Gly Ser Tyr Cys Gln
965 970 975cag gtg gac att gaa
aag ctg aaa atc aac gga gac tct gaa gca ctg 3395Gln Val Asp Ile Glu
Lys Leu Lys Ile Asn Gly Asp Ser Glu Ala Leu 980
985 990agt cct cac ggt gag tcc acg gat aca gcc tct gac
ttt gaa ggt cac 3443Ser Pro His Gly Glu Ser Thr Asp Thr Ala Ser Asp
Phe Glu Gly His 995 1000 1005ctc
acg gag gac agc agt gag gct gac act aga gaa gct gca gtg 3488Leu
Thr Glu Asp Ser Ser Glu Ala Asp Thr Arg Glu Ala Ala Val 1010
1015 1020aca aag gga tct tcg gtg gac aag gat
gag aaa ccc aat tgg aac 3533Thr Lys Gly Ser Ser Val Asp Lys Asp
Glu Lys Pro Asn Trp Asn 1025 1030
1035caa tct gcc cca ctg tcc aag gtg aat ggt gac atg cgt ctg gtt
3578Gln Ser Ala Pro Leu Ser Lys Val Asn Gly Asp Met Arg Leu Val
1040 1045 1050aca agg aca gat ggg atg
gtt gct cct cag agc tgg gtg tct cga 3623Thr Arg Thr Asp Gly Met
Val Ala Pro Gln Ser Trp Val Ser Arg 1055 1060
1065gta tgt gcg gtc cgc caa aag atc cca gat tcc cta ctg ctg
gcc 3668Val Cys Ala Val Arg Gln Lys Ile Pro Asp Ser Leu Leu Leu
Ala 1070 1075 1080agt act gag tac cag
cca aga gcc gtg tgc ctg tcc atg cct ggg 3713Ser Thr Glu Tyr Gln
Pro Arg Ala Val Cys Leu Ser Met Pro Gly 1085 1090
1095tcc tca gtg gag gcc act aac cca ctt gtg atg cag ttg
ctg cag 3758Ser Ser Val Glu Ala Thr Asn Pro Leu Val Met Gln Leu
Leu Gln 1100 1105 1110ggt agc ttg ccc
cta gag aag gtt ctt cca cca gcc cac gat gac 3803Gly Ser Leu Pro
Leu Glu Lys Val Leu Pro Pro Ala His Asp Asp 1115
1120 1125agc atg tca gaa tcc cca caa gta cca ctt aca
aaa gac cag agc 3848Ser Met Ser Glu Ser Pro Gln Val Pro Leu Thr
Lys Asp Gln Ser 1130 1135 1140cat ggc
tcg cta cgc atg gga tct tta cat ggt ctt gga aaa aac 3893His Gly
Ser Leu Arg Met Gly Ser Leu His Gly Leu Gly Lys Asn 1145
1150 1155agt ggc atg gtt gat gga agc agc ccc agt
tct tta agg gct ttg 3938Ser Gly Met Val Asp Gly Ser Ser Pro Ser
Ser Leu Arg Ala Leu 1160 1165 1170aag
gag cct ctt ctg cca gat agc tgt gaa aca ggc act ggt ctt 3983Lys
Glu Pro Leu Leu Pro Asp Ser Cys Glu Thr Gly Thr Gly Leu 1175
1180 1185gcc agg att gag gcc acc cag gct cct
gga gca ccc caa aag aat 4028Ala Arg Ile Glu Ala Thr Gln Ala Pro
Gly Ala Pro Gln Lys Asn 1190 1195
1200tgc aag gca gtc cca agt ttt gac tcc ctc cat cca gtg aca aat
4073Cys Lys Ala Val Pro Ser Phe Asp Ser Leu His Pro Val Thr Asn
1205 1210 1215ccc att aca tcc tct agg
aaa ctg gaa gaa atg gat tcc aaa gag 4118Pro Ile Thr Ser Ser Arg
Lys Leu Glu Glu Met Asp Ser Lys Glu 1220 1225
1230cag ttc tct tcc ttt agt tgt gaa gat cag aag gaa gtc cgt
gct 4163Gln Phe Ser Ser Phe Ser Cys Glu Asp Gln Lys Glu Val Arg
Ala 1235 1240 1245atg tca cag gac agt
aat tca aat gct gct cca gga aag agc cca 4208Met Ser Gln Asp Ser
Asn Ser Asn Ala Ala Pro Gly Lys Ser Pro 1250 1255
1260gga gat ctt act acc tcg aga aca cct cgt ttc tca tct
cca aat 4253Gly Asp Leu Thr Thr Ser Arg Thr Pro Arg Phe Ser Ser
Pro Asn 1265 1270 1275gtg atc tcc ttt
ggt cca gag cag aca ggt cgg gcc ctg ggt gat 4298Val Ile Ser Phe
Gly Pro Glu Gln Thr Gly Arg Ala Leu Gly Asp 1280
1285 1290cag agc aat gtt aca ggc caa ggg aag aag ctt
ttt ggc tct ggg 4343Gln Ser Asn Val Thr Gly Gln Gly Lys Lys Leu
Phe Gly Ser Gly 1295 1300 1305aat gtg
gct gca acc ctt cag cgc ccc agg cct gcg gac ccg atg 4388Asn Val
Ala Ala Thr Leu Gln Arg Pro Arg Pro Ala Asp Pro Met 1310
1315 1320cct ctt cct gct gag atc cct cca gtt ttt
ccc agt ggg aag ttg 4433Pro Leu Pro Ala Glu Ile Pro Pro Val Phe
Pro Ser Gly Lys Leu 1325 1330 1335gga
cca agc aca aac tcc atg tct ggt ggg gta cag act cca agg 4478Gly
Pro Ser Thr Asn Ser Met Ser Gly Gly Val Gln Thr Pro Arg 1340
1345 1350gaa gac tgg gct cca aag cca cat gcc
ttt gtt ggc agc gtc aag 4523Glu Asp Trp Ala Pro Lys Pro His Ala
Phe Val Gly Ser Val Lys 1355 1360
1365aat gag aag act ttt gtg ggg ggt cct ctt aag gca aat gcc gag
4568Asn Glu Lys Thr Phe Val Gly Gly Pro Leu Lys Ala Asn Ala Glu
1370 1375 1380aac agg aaa gct act ggg
cat agt ccc ctg gaa ctg gtg ggt cac 4613Asn Arg Lys Ala Thr Gly
His Ser Pro Leu Glu Leu Val Gly His 1385 1390
1395ttg gaa ggg atg ccc ttt gtc atg gac ttg ccc ttc tgg aaa
tta 4658Leu Glu Gly Met Pro Phe Val Met Asp Leu Pro Phe Trp Lys
Leu 1400 1405 1410ccc cga gag cca ggg
aag ggg ctc agt gag cct ctg gag cct tct 4703Pro Arg Glu Pro Gly
Lys Gly Leu Ser Glu Pro Leu Glu Pro Ser 1415 1420
1425tct ctc ccc tcc caa ctc agc atc aag cag gca ttt tat
ggg aag 4748Ser Leu Pro Ser Gln Leu Ser Ile Lys Gln Ala Phe Tyr
Gly Lys 1430 1435 1440ctt tct aaa ctc
caa ctg agt tcc acc agc ttt aat tat tcc tct 4793Leu Ser Lys Leu
Gln Leu Ser Ser Thr Ser Phe Asn Tyr Ser Ser 1445
1450 1455agc tct ccc acc ttt ccc aaa ggc ctt gct gga
agt gtg gtg cag 4838Ser Ser Pro Thr Phe Pro Lys Gly Leu Ala Gly
Ser Val Val Gln 1460 1465 1470ctg agc
cac aaa gca aac ttt ggt gcg agc cac agt gca tca ctt 4883Leu Ser
His Lys Ala Asn Phe Gly Ala Ser His Ser Ala Ser Leu 1475
1480 1485tcc ttg caa atg ttc act gac agc agc acg
gtg gaa agc atc tcg 4928Ser Leu Gln Met Phe Thr Asp Ser Ser Thr
Val Glu Ser Ile Ser 1490 1495 1500ctc
cag tgt gcg tgc agc ctg aaa gcc atg atc atg tgc caa ggc 4973Leu
Gln Cys Ala Cys Ser Leu Lys Ala Met Ile Met Cys Gln Gly 1505
1510 1515tgc ggt gcg ttc tgt cac gat gac tgt
att gga ccc tca aag ctc 5018Cys Gly Ala Phe Cys His Asp Asp Cys
Ile Gly Pro Ser Lys Leu 1520 1525
1530tgt gta ttg tgc ctt gtg gtg aga taa taaattatgg ccatgggaaa
5065Cys Val Leu Cys Leu Val Val Arg 1535
1540cattgtatat ttagtgtgtg tattttgata atgattgatc ttaaatctgt atacagaata
5125tcattgatat aatactcttt aggcaggagc actcttgcct tcccccaaaa tttacactgc
5185taaagccctc tgtcacttgg cgacccttct ggtcttgctg gaggggtttc ctgggtataa
5245cccattgggc tgcccaaggc cagccagcct gagctctcct gcaagacaga gcctgatgtg
5305gcacggagtg gggttgcggg gggtgggggg actgcctgac tcccagaggg acttgaaact
5365gaagcaagaa ggttgcattc tccaccaagg gagttaacct acctgaacta agtagaaatg
5425ccagtcttcc actaccccct ccctgccatc ttttcttctg ctactttggg gagttgatgg
5485ccaggaaaga agccagcaca gggttaaagt aactcctggc attgcccacc agggggctgg
5545tgcacctgct gacctcaggg tcacagttga gtcatttgcc agttgacgga gcaagtttga
5605ccttggttct gttgctgaag caaatttgga acttttctgt ctcagtgtga tccactaacc
5665cacaggatca tttggaacct tgaatagctc tgcttggaca atggggttgg ggaatagggt
5725tgtctttcct atgaaaatgc catctgtaga ccttgtgagt cagccgtcca gatgtttgca
5785ggtgaattcc tctgcttgac atcctccctg tcactttgga ccctatggga gtgggcatct
5845ccacgcacct gtgtatgtga aagtcatttt acatttcaaa gcagtgtgtg tttcttattt
5905ttatattttt aactctttat tcttggatgt ataaagtgaa ctttttggct tctgtaagta
5965tgctctatgc acctctaatg ttttatcatg tatttatatg ttgtacacag tactggctga
6025ttctgtaaat ggatgtattg tacagagaac atgaacgtct cttcctaatt ttacatcttc
6085agcatcattg cattaaagtg gtgtaatctc cttctctaca tctgttgtca gagccactga
6145gtgctgtgct gctcgacgtg agggtgaaat gattgacttg tgacctgcca ggttgcccga
6205tgccctgttg ggtcaccggc tggacctgct gcagcctgca gagccacagt cagcctgccc
6265acatgccacc gagcaaacgc atcttgcttt tcacatctct cctcctacag ccttaatggc
6325tgcttgctgc catatgtgac aaatcaccac caccagtgtt aagtgcttct ggattcatgg
6385gtgagttccc tgggcagccc ccaggaaggc cttccagatc tggctccagg gtcaccacct
6445gtcacagcaa tacctgggac catgctctcc tgggactgtg aggctccttt tgacgtactt
6505ttgacatcag gcaggtttgg gaagaaacaa agccatgcct gctcctgcct ctctcccaac
6565atgtttccag caagtagatg cccctgtgtg tgttttccct tgccttgttt cctgccttat
6625atcttgtatt tcgacttatt acagagttga gggttcttgc ttaatttaga tcaagtataa
6685aatttgtatg acttcaagtc tcattttatc tgaaaggttt ttttctcatt taatctgatg
6745tggcattttc gtcatctgaa gcatgagtga caagttggga atgatgtggt gatttagaat
6805gcagtattgg ccaagtccaa gttgtcaact taagcgtctg tttaccaaag accgggaaca
6865ggggcccaaa catgtccagt cctcttcttc cctctgctgg aacctttggg gacactcaag
6925ggtacagttt gacactgatc tggtccatga ggctgcccag agaaagcact gcttctgtat
6985gtctcttgtg gtattggaac aataaacccg tacaacctgc a
7026481541PRTHomo sapiens 48Met Lys Asp Lys Gln Lys Lys Lys Lys Glu Arg
Thr Trp Ala Glu Ala1 5 10
15Ala Arg Leu Val Leu Glu Asn Tyr Ser Asp Ala Pro Met Thr Pro Lys
20 25 30Gln Ile Leu Gln Val Ile Glu
Ala Glu Gly Leu Lys Glu Met Arg Ser 35 40
45Gly Thr Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Ser Asn
Ser 50 55 60Arg Gly Gly Glu Gly Leu
Phe Tyr Lys Leu Pro Gly Arg Ile Ser Leu65 70
75 80Phe Thr Leu Lys Lys Asp Ala Leu Gln Trp Ser
Arg His Pro Ala Thr 85 90
95Val Glu Gly Glu Glu Pro Glu Asp Thr Ala Asp Val Glu Ser Cys Gly
100 105 110Ser Asn Glu Ala Ser Thr
Val Ser Gly Glu Asn Asp Val Ser Leu Asp 115 120
125Glu Thr Ser Ser Asn Ala Ser Cys Ser Thr Glu Ser Gln Ser
Arg Pro 130 135 140Leu Ser Asn Pro Arg
Asp Ser Tyr Arg Ala Ser Ser Gln Ala Asn Lys145 150
155 160Gln Lys Lys Lys Thr Gly Val Met Leu Pro
Arg Val Val Leu Thr Pro 165 170
175Leu Lys Val Asn Gly Ala His Val Glu Ser Ala Ser Gly Phe Ser Gly
180 185 190Cys His Ala Asp Gly
Glu Ser Gly Ser Pro Ser Ser Ser Ser Ser Gly 195
200 205Ser Leu Ala Leu Gly Ser Ala Ala Ile Arg Gly Gln
Ala Glu Val Thr 210 215 220Gln Asp Pro
Ala Pro Leu Leu Arg Gly Phe Arg Lys Pro Ala Thr Gly225
230 235 240Gln Met Lys Arg Asn Arg Gly
Glu Glu Ile Asp Phe Glu Thr Pro Gly 245
250 255Ser Ile Leu Val Asn Thr Asn Leu Arg Ala Leu Ile
Asn Ser Arg Thr 260 265 270Phe
His Ala Leu Pro Ser His Phe Gln Gln Gln Leu Leu Phe Leu Leu 275
280 285Pro Glu Val Asp Arg Gln Val Gly Thr
Asp Gly Leu Leu Arg Leu Ser 290 295
300Ser Ser Ala Leu Asn Asn Glu Phe Phe Thr His Ala Ala Gln Ser Trp305
310 315 320Arg Glu Arg Leu
Ala Asp Gly Glu Phe Thr His Glu Met Gln Val Arg 325
330 335Ile Arg Gln Glu Met Glu Lys Glu Lys Lys
Val Glu Gln Trp Lys Glu 340 345
350Lys Phe Phe Glu Asp Tyr Tyr Gly Gln Lys Leu Gly Leu Thr Lys Glu
355 360 365Glu Ser Leu Gln Gln Asn Val
Gly Gln Glu Glu Ala Glu Ile Lys Ser 370 375
380Gly Leu Cys Val Pro Gly Glu Ser Val Arg Ile Gln Arg Gly Pro
Ala385 390 395 400Thr Arg
Gln Arg Asp Gly His Phe Lys Lys Arg Ser Arg Pro Asp Leu
405 410 415Arg Thr Arg Ala Arg Arg Asn
Leu Tyr Lys Lys Gln Glu Ser Glu Gln 420 425
430Ala Gly Val Ala Lys Asp Ala Lys Ser Val Ala Ser Asp Val
Pro Leu 435 440 445Tyr Lys Asp Gly
Glu Ala Lys Thr Asp Pro Ala Gly Leu Ser Ser Pro 450
455 460His Leu Pro Gly Thr Ser Ser Ala Ala Pro Asp Leu
Glu Gly Pro Glu465 470 475
480Phe Pro Val Glu Ser Val Ala Ser Arg Ile Gln Ala Glu Pro Asp Asn
485 490 495Leu Ala Arg Ala Ser
Ala Ser Pro Asp Arg Ile Pro Ser Leu Pro Gln 500
505 510Glu Thr Val Asp Gln Glu Pro Lys Asp Gln Lys Arg
Lys Ser Phe Glu 515 520 525Gln Ala
Ala Ser Ala Ser Phe Pro Glu Lys Lys Pro Arg Leu Glu Asp 530
535 540Arg Gln Ser Phe Arg Asn Thr Ile Glu Ser Val
His Thr Glu Lys Pro545 550 555
560Gln Pro Thr Lys Glu Glu Pro Lys Val Pro Pro Ile Arg Ile Gln Leu
565 570 575Ser Arg Ile Lys
Pro Pro Trp Val Val Lys Gly Gln Pro Thr Tyr Gln 580
585 590Ile Cys Pro Arg Ile Ile Pro Thr Thr Glu Ser
Ser Cys Arg Gly Trp 595 600 605Thr
Gly Ala Arg Thr Leu Ala Asp Ile Lys Ala Arg Ala Leu Gln Val 610
615 620Arg Gly Ala Arg Gly His His Cys His Arg
Glu Ala Ala Thr Thr Ala625 630 635
640Ile Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Ala Thr
Asp 645 650 655Glu Gly Gly
Gly Arg Gly Ser Ser Ser Gly Asp Gly Gly Glu Ala Cys 660
665 670Gly His Pro Glu Pro Arg Gly Gly Pro Ser
Thr Pro Gly Lys Cys Thr 675 680
685Ser Asp Leu Gln Arg Thr Gln Leu Leu Pro Pro Tyr Pro Leu Asn Gly 690
695 700Glu His Thr Gln Ala Gly Thr Ala
Met Ser Arg Ala Arg Arg Glu Asp705 710
715 720Leu Pro Ser Leu Arg Lys Glu Glu Ser Cys Leu Leu
Gln Arg Ala Thr 725 730
735Val Gly Leu Thr Asp Gly Leu Gly Asp Ala Ser Gln Leu Pro Val Ala
740 745 750Pro Thr Gly Asp Gln Pro
Cys Gln Ala Leu Pro Leu Leu Ser Ser Gln 755 760
765Thr Ser Val Ala Glu Arg Leu Val Glu Gln Pro Gln Leu His
Pro Asp 770 775 780Val Arg Thr Glu Cys
Glu Ser Gly Thr Thr Ser Trp Glu Ser Asp Asp785 790
795 800Glu Glu Gln Gly Pro Thr Val Pro Ala Asp
Asn Gly Pro Ile Pro Ser 805 810
815Leu Val Gly Asp Asp Thr Leu Glu Lys Gly Thr Gly Gln Ala Leu Asp
820 825 830Ser His Pro Thr Met
Lys Asp Pro Val Asn Val Thr Pro Ser Ser Thr 835
840 845Pro Glu Ser Ser Pro Thr Asp Cys Leu Gln Asn Arg
Ala Phe Asp Asp 850 855 860Glu Leu Gly
Leu Gly Gly Ser Cys Pro Pro Met Arg Glu Ser Asp Thr865
870 875 880Arg Gln Glu Asn Leu Lys Thr
Lys Ala Leu Val Ser Asn Ser Ser Leu 885
890 895His Trp Ile Pro Ile Pro Ser Asn Asp Glu Val Val
Lys Gln Pro Lys 900 905 910Pro
Glu Ser Arg Glu His Ile Pro Ser Val Glu Pro Gln Val Gly Glu 915
920 925Glu Trp Glu Lys Ala Ala Pro Thr Pro
Pro Ala Leu Pro Gly Asp Leu 930 935
940Thr Ala Glu Glu Gly Leu Asp Pro Leu Asp Ser Leu Thr Ser Leu Trp945
950 955 960Thr Val Pro Ser
Arg Gly Gly Ser Asp Ser Asn Gly Ser Tyr Cys Gln 965
970 975Gln Val Asp Ile Glu Lys Leu Lys Ile Asn
Gly Asp Ser Glu Ala Leu 980 985
990Ser Pro His Gly Glu Ser Thr Asp Thr Ala Ser Asp Phe Glu Gly His
995 1000 1005Leu Thr Glu Asp Ser Ser
Glu Ala Asp Thr Arg Glu Ala Ala Val 1010 1015
1020Thr Lys Gly Ser Ser Val Asp Lys Asp Glu Lys Pro Asn Trp
Asn 1025 1030 1035Gln Ser Ala Pro Leu
Ser Lys Val Asn Gly Asp Met Arg Leu Val 1040 1045
1050Thr Arg Thr Asp Gly Met Val Ala Pro Gln Ser Trp Val
Ser Arg 1055 1060 1065Val Cys Ala Val
Arg Gln Lys Ile Pro Asp Ser Leu Leu Leu Ala 1070
1075 1080Ser Thr Glu Tyr Gln Pro Arg Ala Val Cys Leu
Ser Met Pro Gly 1085 1090 1095Ser Ser
Val Glu Ala Thr Asn Pro Leu Val Met Gln Leu Leu Gln 1100
1105 1110Gly Ser Leu Pro Leu Glu Lys Val Leu Pro
Pro Ala His Asp Asp 1115 1120 1125Ser
Met Ser Glu Ser Pro Gln Val Pro Leu Thr Lys Asp Gln Ser 1130
1135 1140His Gly Ser Leu Arg Met Gly Ser Leu
His Gly Leu Gly Lys Asn 1145 1150
1155Ser Gly Met Val Asp Gly Ser Ser Pro Ser Ser Leu Arg Ala Leu
1160 1165 1170Lys Glu Pro Leu Leu Pro
Asp Ser Cys Glu Thr Gly Thr Gly Leu 1175 1180
1185Ala Arg Ile Glu Ala Thr Gln Ala Pro Gly Ala Pro Gln Lys
Asn 1190 1195 1200Cys Lys Ala Val Pro
Ser Phe Asp Ser Leu His Pro Val Thr Asn 1205 1210
1215Pro Ile Thr Ser Ser Arg Lys Leu Glu Glu Met Asp Ser
Lys Glu 1220 1225 1230Gln Phe Ser Ser
Phe Ser Cys Glu Asp Gln Lys Glu Val Arg Ala 1235
1240 1245Met Ser Gln Asp Ser Asn Ser Asn Ala Ala Pro
Gly Lys Ser Pro 1250 1255 1260Gly Asp
Leu Thr Thr Ser Arg Thr Pro Arg Phe Ser Ser Pro Asn 1265
1270 1275Val Ile Ser Phe Gly Pro Glu Gln Thr Gly
Arg Ala Leu Gly Asp 1280 1285 1290Gln
Ser Asn Val Thr Gly Gln Gly Lys Lys Leu Phe Gly Ser Gly 1295
1300 1305Asn Val Ala Ala Thr Leu Gln Arg Pro
Arg Pro Ala Asp Pro Met 1310 1315
1320Pro Leu Pro Ala Glu Ile Pro Pro Val Phe Pro Ser Gly Lys Leu
1325 1330 1335Gly Pro Ser Thr Asn Ser
Met Ser Gly Gly Val Gln Thr Pro Arg 1340 1345
1350Glu Asp Trp Ala Pro Lys Pro His Ala Phe Val Gly Ser Val
Lys 1355 1360 1365Asn Glu Lys Thr Phe
Val Gly Gly Pro Leu Lys Ala Asn Ala Glu 1370 1375
1380Asn Arg Lys Ala Thr Gly His Ser Pro Leu Glu Leu Val
Gly His 1385 1390 1395Leu Glu Gly Met
Pro Phe Val Met Asp Leu Pro Phe Trp Lys Leu 1400
1405 1410Pro Arg Glu Pro Gly Lys Gly Leu Ser Glu Pro
Leu Glu Pro Ser 1415 1420 1425Ser Leu
Pro Ser Gln Leu Ser Ile Lys Gln Ala Phe Tyr Gly Lys 1430
1435 1440Leu Ser Lys Leu Gln Leu Ser Ser Thr Ser
Phe Asn Tyr Ser Ser 1445 1450 1455Ser
Ser Pro Thr Phe Pro Lys Gly Leu Ala Gly Ser Val Val Gln 1460
1465 1470Leu Ser His Lys Ala Asn Phe Gly Ala
Ser His Ser Ala Ser Leu 1475 1480
1485Ser Leu Gln Met Phe Thr Asp Ser Ser Thr Val Glu Ser Ile Ser
1490 1495 1500Leu Gln Cys Ala Cys Ser
Leu Lys Ala Met Ile Met Cys Gln Gly 1505 1510
1515Cys Gly Ala Phe Cys His Asp Asp Cys Ile Gly Pro Ser Lys
Leu 1520 1525 1530Cys Val Leu Cys Leu
Val Val Arg 1535 1540493124DNAHomo
sapiensCDS(313)..(1731) 49taagatccac atcagctcaa ctgcacttgc ctcgcagagg
cagcccgctc acttcccgcg 60gaggcgctcc ccggcgccgc gctccgcggc agccgcctgc
ccccggcgct gcccccgccc 120gccgcgccgc cgccgccgcc gcgcacgccg cgccccgcag
ctctgggctt cctcttcgcc 180cgggtggcgt tgggcccgcg cgggcgctcg ggtgactgca
gctgctcagc tcccctcccc 240cgccccgcgc cgcgcggccg cccgtcgctt cgcacagggc
tggatggttg tattgggcag 300ggtggctcca gg atg tta gga act gtg aag atg gaa
ggg cat gaa acc agc 351 Met Leu Gly Thr Val Lys Met Glu
Gly His Glu Thr Ser 1 5
10gac tgg aac agc tac tac gca gac acg cag gag gcc tac tcc tcc gtc
399Asp Trp Asn Ser Tyr Tyr Ala Asp Thr Gln Glu Ala Tyr Ser Ser Val 15
20 25ccg gtc agc aac atg aac tca ggc ctg
ggc tcc atg aac tcc atg aac 447Pro Val Ser Asn Met Asn Ser Gly Leu
Gly Ser Met Asn Ser Met Asn30 35 40
45acc tac atg acc atg aac acc atg act acg agc ggc aac atg
acc ccg 495Thr Tyr Met Thr Met Asn Thr Met Thr Thr Ser Gly Asn Met
Thr Pro 50 55 60gcg tcc
ttc aac atg tcc tat gcc aac ccg ggc cta ggg gcc ggc ctg 543Ala Ser
Phe Asn Met Ser Tyr Ala Asn Pro Gly Leu Gly Ala Gly Leu 65
70 75agt ccc ggc gca gta gcc ggc atg ccg
ggg ggc tcg gcg ggc gcc atg 591Ser Pro Gly Ala Val Ala Gly Met Pro
Gly Gly Ser Ala Gly Ala Met 80 85
90aac agc atg act gcg gcc ggc gtg acg gcc atg ggt acg gcg ctg agc
639Asn Ser Met Thr Ala Ala Gly Val Thr Ala Met Gly Thr Ala Leu Ser 95
100 105ccg agc ggc atg ggc gcc atg ggt
gcg cag cag gcg gcc tcc atg aat 687Pro Ser Gly Met Gly Ala Met Gly
Ala Gln Gln Ala Ala Ser Met Asn110 115
120 125ggc ctg ggc ccc tac gcg gcc gcc atg aac ccg tgc
atg agc ccc atg 735Gly Leu Gly Pro Tyr Ala Ala Ala Met Asn Pro Cys
Met Ser Pro Met 130 135
140gcg tac gcg ccg tcc aac ctg ggc cgc agc cgc gcg ggc ggc ggc ggc
783Ala Tyr Ala Pro Ser Asn Leu Gly Arg Ser Arg Ala Gly Gly Gly Gly
145 150 155gac gcc aag acg ttc aag
cgc agc tac ccg cac gcc aag ccg ccc tac 831Asp Ala Lys Thr Phe Lys
Arg Ser Tyr Pro His Ala Lys Pro Pro Tyr 160 165
170tcg tac atc tcg ctc atc acc atg gcc atc cag cag gcg ccc
agc aag 879Ser Tyr Ile Ser Leu Ile Thr Met Ala Ile Gln Gln Ala Pro
Ser Lys 175 180 185atg ctc acg ctg agc
gag atc tac cag tgg atc atg gac ctc ttc ccc 927Met Leu Thr Leu Ser
Glu Ile Tyr Gln Trp Ile Met Asp Leu Phe Pro190 195
200 205tat tac cgg cag aac cag cag cgc tgg cag
aac tcc atc cgc cac tcg 975Tyr Tyr Arg Gln Asn Gln Gln Arg Trp Gln
Asn Ser Ile Arg His Ser 210 215
220ctg tcc ttc aat gac tgc ttc gtc aag gtg gca cgc tcc ccg gac aag
1023Leu Ser Phe Asn Asp Cys Phe Val Lys Val Ala Arg Ser Pro Asp Lys
225 230 235ccg ggc aag ggc tcc tac
tgg acg ctg cac ccg gac tcc ggc aac atg 1071Pro Gly Lys Gly Ser Tyr
Trp Thr Leu His Pro Asp Ser Gly Asn Met 240 245
250ttc gag aac ggc tgc tac ttg cgc cgc cag aag cgc ttc aag
tgc gag 1119Phe Glu Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys
Cys Glu 255 260 265aag cag ccg ggg gcc
ggc ggc ggg ggc ggg agc gga agc ggg ggc agc 1167Lys Gln Pro Gly Ala
Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Ser270 275
280 285ggc gcc aag ggc ggc cct gag agc cgc aag
gac ccc tct ggc gcc tct 1215Gly Ala Lys Gly Gly Pro Glu Ser Arg Lys
Asp Pro Ser Gly Ala Ser 290 295
300aac ccc agc gcc gac tcg ccc ctc cat cgg ggt gtg cac ggg aag acc
1263Asn Pro Ser Ala Asp Ser Pro Leu His Arg Gly Val His Gly Lys Thr
305 310 315ggc cag cta gag ggc gcg
ccg gcc ccc ggg ccc gcc gcc agc ccc cag 1311Gly Gln Leu Glu Gly Ala
Pro Ala Pro Gly Pro Ala Ala Ser Pro Gln 320 325
330act ctg gac cac agt ggg gcg acg gcg aca ggg ggc gcc tcg
gag ttg 1359Thr Leu Asp His Ser Gly Ala Thr Ala Thr Gly Gly Ala Ser
Glu Leu 335 340 345aag act cca gcc tcc
tca act gcg ccc ccc ata agc tcc ggg ccc ggg 1407Lys Thr Pro Ala Ser
Ser Thr Ala Pro Pro Ile Ser Ser Gly Pro Gly350 355
360 365gcg ctg gcc tct gtg ccc gcc tct cac ccg
gca cac ggc ttg gca ccc 1455Ala Leu Ala Ser Val Pro Ala Ser His Pro
Ala His Gly Leu Ala Pro 370 375
380cac gag tcc cag ctg cac ctg aaa ggg gac ccc cac tac tcc ttc aac
1503His Glu Ser Gln Leu His Leu Lys Gly Asp Pro His Tyr Ser Phe Asn
385 390 395cac ccg ttc tcc atc aac
aac ctc atg tcc tcc tcg gag cag cag cat 1551His Pro Phe Ser Ile Asn
Asn Leu Met Ser Ser Ser Glu Gln Gln His 400 405
410aag ctg gac ttc aag gca tac gaa cag gca ctg caa tac tcg
cct tac 1599Lys Leu Asp Phe Lys Ala Tyr Glu Gln Ala Leu Gln Tyr Ser
Pro Tyr 415 420 425ggc tct acg ttg ccc
gcc agc ctg cct cta ggc agc gcc tcg gtg acc 1647Gly Ser Thr Leu Pro
Ala Ser Leu Pro Leu Gly Ser Ala Ser Val Thr430 435
440 445acc agg agc ccc atc gag ccc tca gcc ctg
gag ccg gcg tac tac caa 1695Thr Arg Ser Pro Ile Glu Pro Ser Ala Leu
Glu Pro Ala Tyr Tyr Gln 450 455
460ggt gtg tat tcc aga ccc gtc cta aac act tcc tag ctcccgggac
1741Gly Val Tyr Ser Arg Pro Val Leu Asn Thr Ser 465
470tggggggttt gtctggcata gccatgctgg tagcaagaga gaaaaaatca
acagcaaaca 1801aaaccacaca aaccaaaccg tcaacagcat aataaaatcc caacaactat
ttttatttca 1861tttttcatgc acaacctttc ccccagtgca aaagactgtt actttattat
tgtattcaaa 1921attcattgtg tatattacta caaagacaac cccaaaccaa tttttttcct
gcgaagttta 1981atgatccaca agtgtatata tgaaattctc ctccttcctt gcccccctct
ctttcttccc 2041tctttcccct ccagacattc tagtttgtgg agggttattt aaaaaaacaa
aaaaggaaga 2101tggtcaagtt tgtaaaatat ttgtttgtgc tttttccccc tccttacctg
accccctacg 2161agtttacagg tctgtggcaa tactcttaac cataagaatt gaaatggtga
agaaacaagt 2221atacactaga ggctcttaaa agtattgaaa gacaatactg ctgttatata
gcaagacata 2281aacagattat aaacatcaga gccatttgct tctcagttta catttctgat
acatgcagat 2341agcagatgtc tttaaatgaa atacatgtat attgtgtatg gacttaatta
tgcacatgct 2401cagatgtgta gacatcctcc gtatatttac ataacatata gaggtaatag
ataggtgata 2461tacatgatac attctcaaga gttgcttgac cgaaagttac aaggacccca
acccctttgt 2521cctctctacc cacagatggc cctgggaatc aattcctcag gaattgccct
caagaactct 2581gcttcttgct ttgcagagtg ccatggtcat gtcattctga ggtcacataa
cacataaaat 2641tagtttctat gagtgtatac catttaaaga attttttttt cagtaaaagg
gaatattaca 2701atgttggagg agagataagt tatagggagc tggatttcaa aacgtggtcc
aagattcaaa 2761aatcctattg atagtggcca ttttaatcat tgccatcgtg tgcttgtttc
atccagtgtt 2821atgcactttc cacagttgga catggtgtta gtatagccag acgggtttca
ttattatttc 2881tctttgcttt ctcaatgtta atttattgca tggtttattc tttttcttta
cagctgaaat 2941tgctttaaat gatggttaaa attacaaatt aaattgttaa tttttatcaa
tgtgattgta 3001attaaaaata ttttgattta aataacaaaa ataataccag attttaagcc
gtggaaaatg 3061ttcttgatca tttgcagtta aggactttaa ataaatcaaa tgttaacaaa
aaaaaaaaaa 3121aaa
312450472PRTHomo sapiens 50Met Leu Gly Thr Val Lys Met Glu Gly
His Glu Thr Ser Asp Trp Asn1 5 10
15Ser Tyr Tyr Ala Asp Thr Gln Glu Ala Tyr Ser Ser Val Pro Val
Ser 20 25 30Asn Met Asn Ser
Gly Leu Gly Ser Met Asn Ser Met Asn Thr Tyr Met 35
40 45Thr Met Asn Thr Met Thr Thr Ser Gly Asn Met Thr
Pro Ala Ser Phe 50 55 60Asn Met Ser
Tyr Ala Asn Pro Gly Leu Gly Ala Gly Leu Ser Pro Gly65 70
75 80Ala Val Ala Gly Met Pro Gly Gly
Ser Ala Gly Ala Met Asn Ser Met 85 90
95Thr Ala Ala Gly Val Thr Ala Met Gly Thr Ala Leu Ser Pro
Ser Gly 100 105 110Met Gly Ala
Met Gly Ala Gln Gln Ala Ala Ser Met Asn Gly Leu Gly 115
120 125Pro Tyr Ala Ala Ala Met Asn Pro Cys Met Ser
Pro Met Ala Tyr Ala 130 135 140Pro Ser
Asn Leu Gly Arg Ser Arg Ala Gly Gly Gly Gly Asp Ala Lys145
150 155 160Thr Phe Lys Arg Ser Tyr Pro
His Ala Lys Pro Pro Tyr Ser Tyr Ile 165
170 175Ser Leu Ile Thr Met Ala Ile Gln Gln Ala Pro Ser
Lys Met Leu Thr 180 185 190Leu
Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr Arg 195
200 205Gln Asn Gln Gln Arg Trp Gln Asn Ser
Ile Arg His Ser Leu Ser Phe 210 215
220Asn Asp Cys Phe Val Lys Val Ala Arg Ser Pro Asp Lys Pro Gly Lys225
230 235 240Gly Ser Tyr Trp
Thr Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn 245
250 255Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe
Lys Cys Glu Lys Gln Pro 260 265
270Gly Ala Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly Ala Lys
275 280 285Gly Gly Pro Glu Ser Arg Lys
Asp Pro Ser Gly Ala Ser Asn Pro Ser 290 295
300Ala Asp Ser Pro Leu His Arg Gly Val His Gly Lys Thr Gly Gln
Leu305 310 315 320Glu Gly
Ala Pro Ala Pro Gly Pro Ala Ala Ser Pro Gln Thr Leu Asp
325 330 335His Ser Gly Ala Thr Ala Thr
Gly Gly Ala Ser Glu Leu Lys Thr Pro 340 345
350Ala Ser Ser Thr Ala Pro Pro Ile Ser Ser Gly Pro Gly Ala
Leu Ala 355 360 365Ser Val Pro Ala
Ser His Pro Ala His Gly Leu Ala Pro His Glu Ser 370
375 380Gln Leu His Leu Lys Gly Asp Pro His Tyr Ser Phe
Asn His Pro Phe385 390 395
400Ser Ile Asn Asn Leu Met Ser Ser Ser Glu Gln Gln His Lys Leu Asp
405 410 415Phe Lys Ala Tyr Glu
Gln Ala Leu Gln Tyr Ser Pro Tyr Gly Ser Thr 420
425 430Leu Pro Ala Ser Leu Pro Leu Gly Ser Ala Ser Val
Thr Thr Arg Ser 435 440 445Pro Ile
Glu Pro Ser Ala Leu Glu Pro Ala Tyr Tyr Gln Gly Val Tyr 450
455 460Ser Arg Pro Val Leu Asn Thr Ser465
470513780DNAHomo sapiensCDS(960)..(2282) 51agagcgctgc cgccgccgct
ttcgcccggg agccgggggc cgggcgccat catgctgagc 60cggctcgggg cgctgctgca
ggaagccgtg ggggcgcgcg agcccagcat tgacctgctg 120caggccttcg tggagcactg
gaagggcatc acgcactact acatcgagag cacagatgaa 180agcacccccg ccaagaagac
agacattccc tggcggctga agcagatgct ggatatcctg 240gtgtatgaag agcagcagca
ggcggccgcg ggtgaggcag ggccctgcct ggagtacctg 300ctgcagcaca agatcctgga
gactctctgc acgctgggca aggccgagta ccccccaggc 360atgcggcagc aggtgttcca
gttcttcagc aaggttctgg cgcaggtgca gcaccccctg 420ctgcattacc tcagcgtcca
caggcctgtg cagaaactcc tccgacttgg tgggactgct 480tccggatccg ttacagaaaa
ggaggaggtg cagttcacca ccgtcctctg ctccaagatc 540cagcaggacc cagagctgct
cgcctacatc ctggaaggta aaaagattgt aggtaggaag 600aaagcatgcg gagaacccac
tgccctgcct aaggacacaa ccagccacgg ggacaaggac 660tgctcccacg atggtgctcc
tgccaggccc cagctggacg gggagtcctg tggggcccag 720gccttgaaca gccacatgcc
tgctgagacc gaggagctgg acggtgggac cacagagagc 780aacctgatta cctccctgct
tgggctgtgc cagagcaaga agagtcgggt ggccttgaag 840gcccaggaga acctgctgct
cctggtgagc atggcctccc cagcagctgc cacctacctg 900gtacagagca gcgcctgctg
ccctgcgatc gtccggcact ttgccagttg taccggtcc 959atg cct gtc ttc ctg gac
ccc gca gac att gcc acc tta gag ggc atc 1007Met Pro Val Phe Leu Asp
Pro Ala Asp Ile Ala Thr Leu Glu Gly Ile1 5
10 15agc tgg agg tta ccc agt gcc ccg tct gat gag gct
tcc ttc cct ggc 1055Ser Trp Arg Leu Pro Ser Ala Pro Ser Asp Glu Ala
Ser Phe Pro Gly 20 25 30aag
gag gcc ttg gct gcc ttc ttg ggc tgg ttt gat tac tgc gac cac 1103Lys
Glu Ala Leu Ala Ala Phe Leu Gly Trp Phe Asp Tyr Cys Asp His 35
40 45ctc atc aca gag gca cac acg gtg gtt
gcg gac gcc ttg gcg aag gct 1151Leu Ile Thr Glu Ala His Thr Val Val
Ala Asp Ala Leu Ala Lys Ala 50 55
60gtg gct gag aac ttc ttc gtg gag acc ctg cag ccc cag ctc ctg cac
1199Val Ala Glu Asn Phe Phe Val Glu Thr Leu Gln Pro Gln Leu Leu His65
70 75 80gtg tcc gag cag
agc atc ttg acc tcc acc gcc ctc ctc aca gcc atg 1247Val Ser Glu Gln
Ser Ile Leu Thr Ser Thr Ala Leu Leu Thr Ala Met 85
90 95ctg cgc cag ctt cgc tcc cct gcg ctg ctg
cgg gag gcc gtg gct ttc 1295Leu Arg Gln Leu Arg Ser Pro Ala Leu Leu
Arg Glu Ala Val Ala Phe 100 105
110ctc ctg ggc aca gac cgg cag cct gaa gcc ccc ggg gac aac ccc cac
1343Leu Leu Gly Thr Asp Arg Gln Pro Glu Ala Pro Gly Asp Asn Pro His
115 120 125acc ctg tat gct cat ctc atc
ggg cat tgt gac cac ctc tct gat gag 1391Thr Leu Tyr Ala His Leu Ile
Gly His Cys Asp His Leu Ser Asp Glu 130 135
140atc agc atc acc aca ctc cgg ctg ttt gag gag ctg ctg cag aag ccc
1439Ile Ser Ile Thr Thr Leu Arg Leu Phe Glu Glu Leu Leu Gln Lys Pro145
150 155 160cac gag ggg atc
atc cac agc ctg gtc ctg cgc aac ctt gag ggc cgc 1487His Glu Gly Ile
Ile His Ser Leu Val Leu Arg Asn Leu Glu Gly Arg 165
170 175cct tac gtg gcc tgg ggc tca cca gag cct
gag agc tat gag gac acc 1535Pro Tyr Val Ala Trp Gly Ser Pro Glu Pro
Glu Ser Tyr Glu Asp Thr 180 185
190cta gac ctg gag gaa gac ccc tac ttc acc gac agc ttc ctg gat tcc
1583Leu Asp Leu Glu Glu Asp Pro Tyr Phe Thr Asp Ser Phe Leu Asp Ser
195 200 205ggc ttt caa act ccc gca aag
cct cgc cta gct cct gct acc agt tac 1631Gly Phe Gln Thr Pro Ala Lys
Pro Arg Leu Ala Pro Ala Thr Ser Tyr 210 215
220gat ggc aaa aca gca gtg acc gag atc gtc aac agt ttc ctg tgc ctg
1679Asp Gly Lys Thr Ala Val Thr Glu Ile Val Asn Ser Phe Leu Cys Leu225
230 235 240gtc ccc gag gaa
gcc aag acc tct gcc ttc ctg gag gag aca ggc tat 1727Val Pro Glu Glu
Ala Lys Thr Ser Ala Phe Leu Glu Glu Thr Gly Tyr 245
250 255gac aca tac gtc cac gat gct tat ggc ctg
ttc cag gag tgc agc tcc 1775Asp Thr Tyr Val His Asp Ala Tyr Gly Leu
Phe Gln Glu Cys Ser Ser 260 265
270cgc gtc gcc tcc tgg ggc tgg cct ctg acc ccc aca cct ttg gac ccc
1823Arg Val Ala Ser Trp Gly Trp Pro Leu Thr Pro Thr Pro Leu Asp Pro
275 280 285cat gag ccc gag cga cct ttc
ttc gag ggc cac ttc ctc cga gtg ctg 1871His Glu Pro Glu Arg Pro Phe
Phe Glu Gly His Phe Leu Arg Val Leu 290 295
300ttt gac cgc atg tcc cgg att ctg gat cag cca tac agc ctg aac ctg
1919Phe Asp Arg Met Ser Arg Ile Leu Asp Gln Pro Tyr Ser Leu Asn Leu305
310 315 320cag gtg acc tcg
gtc ctg tcc cgg ctt gcc ctc ttc ccc cac ccc cat 1967Gln Val Thr Ser
Val Leu Ser Arg Leu Ala Leu Phe Pro His Pro His 325
330 335att cat gag tac ctg ctg gat ccg tac atc
agc ctg gcc ccc ggc tgc 2015Ile His Glu Tyr Leu Leu Asp Pro Tyr Ile
Ser Leu Ala Pro Gly Cys 340 345
350agg agc cta ttc tcc gtg ttg gtg agg gtg atc ggg gac ttg atg cag
2063Arg Ser Leu Phe Ser Val Leu Val Arg Val Ile Gly Asp Leu Met Gln
355 360 365aga atc cag agg gta ccc cag
ttc cca ggc aag ctg ctc ctg gtg cgc 2111Arg Ile Gln Arg Val Pro Gln
Phe Pro Gly Lys Leu Leu Leu Val Arg 370 375
380aag cag ttg acg ggc cag gct cct ggg gag cag ctg gac cac cag acc
2159Lys Gln Leu Thr Gly Gln Ala Pro Gly Glu Gln Leu Asp His Gln Thr385
390 395 400ctc ctc cag ggc
gtg gtg gtg ctg gag gag ttc tgc aag gag ctg gct 2207Leu Leu Gln Gly
Val Val Val Leu Glu Glu Phe Cys Lys Glu Leu Ala 405
410 415gcc att gcc ttc gtc aag ttt ccc cca cat
gat cct cgc cag aac gtc 2255Ala Ile Ala Phe Val Lys Phe Pro Pro His
Asp Pro Arg Gln Asn Val 420 425
430tcc cca gcc ccg gaa ggg cag gtc tga gccagcacca gggcggtggg
2302Ser Pro Ala Pro Glu Gly Gln Val 435
440agactcctgt ccacacctct gccccagagc tgcctcctgc ctggcactgc cgccacactc
2362ccctcctggg atggggcttc tgctcccggg ctcactcaag gagactgcgg catgttgacc
2422acaccagact gggtttcagg gaatgggcat gccaggtgcc aaggagccaa acagatggct
2482ttccaggcag caaggtcctt ggggccttct tggaggagct tgggtgacag ccaggtgagc
2542acccagaccc cagaccctca tgtgctgtgt gcctggcccc ttctgtactg gccatttgtg
2602gccagggcca agcctgtgac tcaactccag gggcaagatg gggagtgagc tgatggctcc
2662gagactggtc aggagcccag gccagtgaga tggggcctgg agccttgtct gtgtcacatt
2722aggtaccatg ggagctgctg agacctgaca ttttgtcccc tgcctacatg gcttggccca
2782tggagaagga gcagtgaatg ggatcgtcgg ggaagcccct cttcctgctc tgctcccctg
2842gaaactgttg caaaactccc agccgcctca tggcaaatgc ccaaagcatg ttccgcaccc
2902aggcgggggc ccctgctaat gagaaccttg gtgcagctgc agccaggagg ggagcgggcc
2962caggagccag gctcaggtcc agctggttcc tctctggcgc cttctgaacc cgtctcagca
3022ggtccacagc acctgggcag aggtcagaga ccaggggagg ccgggccttg ccctcccttc
3082tgcccagggc ccagtgttct tgatagaaga cccttctggg gagccaggga gctcagggga
3142cagataaggg aaggacgccc cctgactcca ggcccctgag cctggcggga agtggctgcg
3202gcccaggcag ccagtcctgg tggtgttctc cctgcatgcc ctccgtggct gggctgccac
3262cccacccggc ccgaatctgt cttgacctgc aggaatacac gggcggcgcc aggcattacc
3322tcacagcggg actacacagt tgctggcttt gctcctgggc aaggaggagc aggccagagc
3382ctcttttgct tccttttctt gcccatgccg cttctagaag ccaggcacag gttgccaaga
3442ggtgacacga aacaggagga aactcagtga cctctgcctc tcccacattc ctccccgcgg
3502gggaggacct cgccgctctg aagagcaccg tgcacatgtg ggtgcacaaa cgtgggtgtt
3562ggtgtggacg gggcgcagat ctccgtggat gaactgcgtc tggactctta gattcataaa
3622atattcgagg gtttgggagt cacagaccct cccctctcct cagtgcactt tggcatttgc
3682acggtgtctt ccccggacag cacagcaata aatggtgtga ttgcgtggaa aaaaaaaaaa
3742aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
378052440PRTHomo sapiens 52Met Pro Val Phe Leu Asp Pro Ala Asp Ile Ala
Thr Leu Glu Gly Ile1 5 10
15Ser Trp Arg Leu Pro Ser Ala Pro Ser Asp Glu Ala Ser Phe Pro Gly
20 25 30Lys Glu Ala Leu Ala Ala Phe
Leu Gly Trp Phe Asp Tyr Cys Asp His 35 40
45Leu Ile Thr Glu Ala His Thr Val Val Ala Asp Ala Leu Ala Lys
Ala 50 55 60Val Ala Glu Asn Phe Phe
Val Glu Thr Leu Gln Pro Gln Leu Leu His65 70
75 80Val Ser Glu Gln Ser Ile Leu Thr Ser Thr Ala
Leu Leu Thr Ala Met 85 90
95Leu Arg Gln Leu Arg Ser Pro Ala Leu Leu Arg Glu Ala Val Ala Phe
100 105 110Leu Leu Gly Thr Asp Arg
Gln Pro Glu Ala Pro Gly Asp Asn Pro His 115 120
125Thr Leu Tyr Ala His Leu Ile Gly His Cys Asp His Leu Ser
Asp Glu 130 135 140Ile Ser Ile Thr Thr
Leu Arg Leu Phe Glu Glu Leu Leu Gln Lys Pro145 150
155 160His Glu Gly Ile Ile His Ser Leu Val Leu
Arg Asn Leu Glu Gly Arg 165 170
175Pro Tyr Val Ala Trp Gly Ser Pro Glu Pro Glu Ser Tyr Glu Asp Thr
180 185 190Leu Asp Leu Glu Glu
Asp Pro Tyr Phe Thr Asp Ser Phe Leu Asp Ser 195
200 205Gly Phe Gln Thr Pro Ala Lys Pro Arg Leu Ala Pro
Ala Thr Ser Tyr 210 215 220Asp Gly Lys
Thr Ala Val Thr Glu Ile Val Asn Ser Phe Leu Cys Leu225
230 235 240Val Pro Glu Glu Ala Lys Thr
Ser Ala Phe Leu Glu Glu Thr Gly Tyr 245
250 255Asp Thr Tyr Val His Asp Ala Tyr Gly Leu Phe Gln
Glu Cys Ser Ser 260 265 270Arg
Val Ala Ser Trp Gly Trp Pro Leu Thr Pro Thr Pro Leu Asp Pro 275
280 285His Glu Pro Glu Arg Pro Phe Phe Glu
Gly His Phe Leu Arg Val Leu 290 295
300Phe Asp Arg Met Ser Arg Ile Leu Asp Gln Pro Tyr Ser Leu Asn Leu305
310 315 320Gln Val Thr Ser
Val Leu Ser Arg Leu Ala Leu Phe Pro His Pro His 325
330 335Ile His Glu Tyr Leu Leu Asp Pro Tyr Ile
Ser Leu Ala Pro Gly Cys 340 345
350Arg Ser Leu Phe Ser Val Leu Val Arg Val Ile Gly Asp Leu Met Gln
355 360 365Arg Ile Gln Arg Val Pro Gln
Phe Pro Gly Lys Leu Leu Leu Val Arg 370 375
380Lys Gln Leu Thr Gly Gln Ala Pro Gly Glu Gln Leu Asp His Gln
Thr385 390 395 400Leu Leu
Gln Gly Val Val Val Leu Glu Glu Phe Cys Lys Glu Leu Ala
405 410 415Ala Ile Ala Phe Val Lys Phe
Pro Pro His Asp Pro Arg Gln Asn Val 420 425
430Ser Pro Ala Pro Glu Gly Gln Val 435
440531175DNAHomo sapiensCDS(68)..(895) 53cccggtcgcc gcggctgccg
cgccgccgct gcaggatagc tagcggccag gagaaataca 60gtggaaa atg caa aac aac
gaa att ata aag cct gcc aaa tac ttc tca 109 Met Gln Asn Asn
Glu Ile Ile Lys Pro Ala Lys Tyr Phe Ser 1 5
10gaa ttg gaa aag agc atc ctg ctg gct tta gta gaa aag tat aaa
tat 157Glu Leu Glu Lys Ser Ile Leu Leu Ala Leu Val Glu Lys Tyr Lys
Tyr15 20 25 30gtg ctg
gaa tgt aag aaa agt gat gcg cga act att gcc ctt aag cag 205Val Leu
Glu Cys Lys Lys Ser Asp Ala Arg Thr Ile Ala Leu Lys Gln 35
40 45cgt acc tgg cag gcg ctg gcc cac
gaa tac aac tct cag ccc agc gtg 253Arg Thr Trp Gln Ala Leu Ala His
Glu Tyr Asn Ser Gln Pro Ser Val 50 55
60tcc ctg cgg gat ttc aaa cag ctg aag aag tgc tgg gag aac atc
aag 301Ser Leu Arg Asp Phe Lys Gln Leu Lys Lys Cys Trp Glu Asn Ile
Lys 65 70 75gct cgg acc aaa aaa
att atg gcc cat gaa agg aga gag aaa gtg aaa 349Ala Arg Thr Lys Lys
Ile Met Ala His Glu Arg Arg Glu Lys Val Lys 80 85
90cgg agc gtc agc cct ctc ctg agt acc cac gtc cta ggg aag
gag aag 397Arg Ser Val Ser Pro Leu Leu Ser Thr His Val Leu Gly Lys
Glu Lys95 100 105 110atc
gcc agc atg ctg ccg gag cag ctc tac ttc ctg cag agc ccc ccg 445Ile
Ala Ser Met Leu Pro Glu Gln Leu Tyr Phe Leu Gln Ser Pro Pro
115 120 125gag gag gag ccc gaa tac cac
ccc gac gcc tca gcc caa gaa tca ttt 493Glu Glu Glu Pro Glu Tyr His
Pro Asp Ala Ser Ala Gln Glu Ser Phe 130 135
140gct gtt tca aat aga gaa ctg tgc gat gat gag aaa gag ttc
ata cat 541Ala Val Ser Asn Arg Glu Leu Cys Asp Asp Glu Lys Glu Phe
Ile His 145 150 155ttt cca gta tgt
gag ggg acc tct caa cct gaa ccc tcg tgt tca gct 589Phe Pro Val Cys
Glu Gly Thr Ser Gln Pro Glu Pro Ser Cys Ser Ala 160
165 170gtc aga ata aca gcc aat aaa aac tac agg agc aaa
acc tct cag gaa 637Val Arg Ile Thr Ala Asn Lys Asn Tyr Arg Ser Lys
Thr Ser Gln Glu175 180 185
190ggt gct tta aaa aag atg cat gag gaa gaa cac cat caa caa atg tcc
685Gly Ala Leu Lys Lys Met His Glu Glu Glu His His Gln Gln Met Ser
195 200 205atc tta caa ctg caa
ctg ata caa atg aat gag gtg cat gtg gcc aaa 733Ile Leu Gln Leu Gln
Leu Ile Gln Met Asn Glu Val His Val Ala Lys 210
215 220atc cag cag ata gag cga gag tgt gag atg gca gag
gag gaa cac agg 781Ile Gln Gln Ile Glu Arg Glu Cys Glu Met Ala Glu
Glu Glu His Arg 225 230 235ata aaa
atg gaa gtt ctc aat aaa aag aag atg tat tgg gaa aga aaa 829Ile Lys
Met Glu Val Leu Asn Lys Lys Lys Met Tyr Trp Glu Arg Lys 240
245 250cta caa act ttt acc aag gaa tgg cct gtt tcc
tca ttt aac cgg ccc 877Leu Gln Thr Phe Thr Lys Glu Trp Pro Val Ser
Ser Phe Asn Arg Pro255 260 265
270ttt ccc aat tcg ccc taa gactttgggg gtggctctct tgtaattaat
925Phe Pro Asn Ser Pro 275ctgtgttggc aaagaatgtc
tggaacatgg acttggcggt cagtaacctg taacagagct 985acaactagga aaattagagt
ggtagtagtc acttatttaa gaattcattc aggtaaacag 1045ctgcaccctc tgtacccctt
aagtggcaaa gaagctgtta tagtcttctg aaaattatca 1105ctatgagtgc tataattctg
aatataatgt ctcttaatta gaattcatac aagaaaaaaa 1165aaaaaaaaaa
117554275PRTHomo sapiens
54Met Gln Asn Asn Glu Ile Ile Lys Pro Ala Lys Tyr Phe Ser Glu Leu1
5 10 15Glu Lys Ser Ile Leu Leu
Ala Leu Val Glu Lys Tyr Lys Tyr Val Leu 20 25
30Glu Cys Lys Lys Ser Asp Ala Arg Thr Ile Ala Leu Lys
Gln Arg Thr 35 40 45Trp Gln Ala
Leu Ala His Glu Tyr Asn Ser Gln Pro Ser Val Ser Leu 50
55 60Arg Asp Phe Lys Gln Leu Lys Lys Cys Trp Glu Asn
Ile Lys Ala Arg65 70 75
80Thr Lys Lys Ile Met Ala His Glu Arg Arg Glu Lys Val Lys Arg Ser
85 90 95Val Ser Pro Leu Leu Ser
Thr His Val Leu Gly Lys Glu Lys Ile Ala 100
105 110Ser Met Leu Pro Glu Gln Leu Tyr Phe Leu Gln Ser
Pro Pro Glu Glu 115 120 125Glu Pro
Glu Tyr His Pro Asp Ala Ser Ala Gln Glu Ser Phe Ala Val 130
135 140Ser Asn Arg Glu Leu Cys Asp Asp Glu Lys Glu
Phe Ile His Phe Pro145 150 155
160Val Cys Glu Gly Thr Ser Gln Pro Glu Pro Ser Cys Ser Ala Val Arg
165 170 175Ile Thr Ala Asn
Lys Asn Tyr Arg Ser Lys Thr Ser Gln Glu Gly Ala 180
185 190Leu Lys Lys Met His Glu Glu Glu His His Gln
Gln Met Ser Ile Leu 195 200 205Gln
Leu Gln Leu Ile Gln Met Asn Glu Val His Val Ala Lys Ile Gln 210
215 220Gln Ile Glu Arg Glu Cys Glu Met Ala Glu
Glu Glu His Arg Ile Lys225 230 235
240Met Glu Val Leu Asn Lys Lys Lys Met Tyr Trp Glu Arg Lys Leu
Gln 245 250 255Thr Phe Thr
Lys Glu Trp Pro Val Ser Ser Phe Asn Arg Pro Phe Pro 260
265 270Asn Ser Pro 275551988DNAHomo
sapiensCDS(12)..(1805) 55cctccgggaa g atg gcg gcc gtg cag gcg gcc gag gtg
aaa gtg gat ggc 50 Met Ala Ala Val Gln Ala Ala Glu Val
Lys Val Asp Gly 1 5 10agc gag
ccg aaa ctg agc aag aat gag ctg aag aga cgc ctg aaa gct 98Ser Glu
Pro Lys Leu Ser Lys Asn Glu Leu Lys Arg Arg Leu Lys Ala 15
20 25gag aag aaa gta gca gag aag gag gcc aaa cag
aag gag ctc agt gag 146Glu Lys Lys Val Ala Glu Lys Glu Ala Lys Gln
Lys Glu Leu Ser Glu30 35 40
45aaa cag cta agc caa gcc act gct gct gcc acc aac cac acc act gat
194Lys Gln Leu Ser Gln Ala Thr Ala Ala Ala Thr Asn His Thr Thr Asp
50 55 60aat ggt gtg ggt cct
gag gaa gag agc gtg gac cca aat caa tac tac 242Asn Gly Val Gly Pro
Glu Glu Glu Ser Val Asp Pro Asn Gln Tyr Tyr 65
70 75aaa atc cgc agt caa gca att cat cag ctg aag gtc
aat ggg gaa gac 290Lys Ile Arg Ser Gln Ala Ile His Gln Leu Lys Val
Asn Gly Glu Asp 80 85 90cca tac
cca cac aag ttc cat gta gac atc tca ctc act gac ttc atc 338Pro Tyr
Pro His Lys Phe His Val Asp Ile Ser Leu Thr Asp Phe Ile 95
100 105caa aaa tat agt cac ctg cag cct ggg gat cac
ctg act gac atc acc 386Gln Lys Tyr Ser His Leu Gln Pro Gly Asp His
Leu Thr Asp Ile Thr110 115 120
125tta aag gtg gca ggt agg atc cat gcc aaa aga gct tct ggg gga aag
434Leu Lys Val Ala Gly Arg Ile His Ala Lys Arg Ala Ser Gly Gly Lys
130 135 140ctc atc ttc tat gat
ctt cga gga gag ggg gtg aag ttg caa gtc atg 482Leu Ile Phe Tyr Asp
Leu Arg Gly Glu Gly Val Lys Leu Gln Val Met 145
150 155gcc aat tcc aga aat tat aaa tca gaa gaa gaa ttt
att cat att aat 530Ala Asn Ser Arg Asn Tyr Lys Ser Glu Glu Glu Phe
Ile His Ile Asn 160 165 170aac aaa
ctg cgt cgg gga gac ata att gga gtt cag ggg aat cct ggt 578Asn Lys
Leu Arg Arg Gly Asp Ile Ile Gly Val Gln Gly Asn Pro Gly 175
180 185aaa acc aag aag ggt gag ctg agc atc att ccg
tat gag atc aca ctg 626Lys Thr Lys Lys Gly Glu Leu Ser Ile Ile Pro
Tyr Glu Ile Thr Leu190 195 200
205ctg tct ccc tgt ttg cat atg tta cct cat ctt cac ttt ggc ctc aaa
674Leu Ser Pro Cys Leu His Met Leu Pro His Leu His Phe Gly Leu Lys
210 215 220gac aag gaa aca agg
tat cgc cag aga tac ttg gac ttg atc ctg aat 722Asp Lys Glu Thr Arg
Tyr Arg Gln Arg Tyr Leu Asp Leu Ile Leu Asn 225
230 235gac ttt gtg agg cag aaa ttt atc atc cgc tct aag
atc atc aca tat 770Asp Phe Val Arg Gln Lys Phe Ile Ile Arg Ser Lys
Ile Ile Thr Tyr 240 245 250ata aga
agt ttc tta gat gag ctg gga ttc cta gag att gaa act ccc 818Ile Arg
Ser Phe Leu Asp Glu Leu Gly Phe Leu Glu Ile Glu Thr Pro 255
260 265atg atg aac atc atc cca ggg gga gcc gtg gcc
aag cct ttc atc act 866Met Met Asn Ile Ile Pro Gly Gly Ala Val Ala
Lys Pro Phe Ile Thr270 275 280
285tat cac aac gag ctg gac atg aac tta tat atg aga att gct cca gaa
914Tyr His Asn Glu Leu Asp Met Asn Leu Tyr Met Arg Ile Ala Pro Glu
290 295 300ctc tat cat aag atg
ctt gtg gtt ggt ggc atc gac cgg gtt tat gaa 962Leu Tyr His Lys Met
Leu Val Val Gly Gly Ile Asp Arg Val Tyr Glu 305
310 315att gga cgc cag ttc cgg aat gag ggg att gat ttg
acg cac aat cct 1010Ile Gly Arg Gln Phe Arg Asn Glu Gly Ile Asp Leu
Thr His Asn Pro 320 325 330gag ttc
acc acc tgt gag ttc tac atg gcc tat gca gac tat cac gat 1058Glu Phe
Thr Thr Cys Glu Phe Tyr Met Ala Tyr Ala Asp Tyr His Asp 335
340 345ctc atg gaa atc acg gag aag atg gtt tca ggg
atg gtg aag cat att 1106Leu Met Glu Ile Thr Glu Lys Met Val Ser Gly
Met Val Lys His Ile350 355 360
365aca ggc agt tac aag gtc acc tac cac cca gat ggc cca gag ggc caa
1154Thr Gly Ser Tyr Lys Val Thr Tyr His Pro Asp Gly Pro Glu Gly Gln
370 375 380gcc tac gat gtt gac
ttc acc cca ccc ttc cgg cga atc aac atg gta 1202Ala Tyr Asp Val Asp
Phe Thr Pro Pro Phe Arg Arg Ile Asn Met Val 385
390 395gaa gag ctt gag aaa gcc ctg ggg atg aag ctg cca
gaa acg aac ctc 1250Glu Glu Leu Glu Lys Ala Leu Gly Met Lys Leu Pro
Glu Thr Asn Leu 400 405 410ttt gaa
act gaa gaa act cgc aaa att ctt gat gat atc tgt gtg gca 1298Phe Glu
Thr Glu Glu Thr Arg Lys Ile Leu Asp Asp Ile Cys Val Ala 415
420 425aaa gct gtt gaa tgc cct cca cct cgg acc aca
gcc agg ctc ctt gac 1346Lys Ala Val Glu Cys Pro Pro Pro Arg Thr Thr
Ala Arg Leu Leu Asp430 435 440
445aag ctt gtt ggg gag ttc ctg gaa gtg act tgc atc aat cct aca ttc
1394Lys Leu Val Gly Glu Phe Leu Glu Val Thr Cys Ile Asn Pro Thr Phe
450 455 460atc tgt gat cac cca
cag ata atg agc cct ttg gct aaa tgg cac cgc 1442Ile Cys Asp His Pro
Gln Ile Met Ser Pro Leu Ala Lys Trp His Arg 465
470 475tct aaa gag ggt ctg act gag cgc ttt gag ctg ttt
gtc atg aag aaa 1490Ser Lys Glu Gly Leu Thr Glu Arg Phe Glu Leu Phe
Val Met Lys Lys 480 485 490gag ata
tgc aat gcg tat act gag ctg aat gat ccc atg cgg cag cgg 1538Glu Ile
Cys Asn Ala Tyr Thr Glu Leu Asn Asp Pro Met Arg Gln Arg 495
500 505cag ctt ttt gaa gaa cag gcc aag gcc aag gct
gca ggt gat gat gag 1586Gln Leu Phe Glu Glu Gln Ala Lys Ala Lys Ala
Ala Gly Asp Asp Glu510 515 520
525gcc atg ttc ata gat gaa aac ttc tgt act gcc ctg gaa tat ggg ctg
1634Ala Met Phe Ile Asp Glu Asn Phe Cys Thr Ala Leu Glu Tyr Gly Leu
530 535 540ccc ccc aca gct ggc
tgg ggc atg ggc att gat cga gtc gcc atg ttt 1682Pro Pro Thr Ala Gly
Trp Gly Met Gly Ile Asp Arg Val Ala Met Phe 545
550 555ctc acg gac tcc aac aac atc aag gaa gta ctt ctg
ttt cct gcc atg 1730Leu Thr Asp Ser Asn Asn Ile Lys Glu Val Leu Leu
Phe Pro Ala Met 560 565 570aaa ccc
gaa gac aag aag gag aat gta gca acc act gat aca ctg gaa 1778Lys Pro
Glu Asp Lys Lys Glu Asn Val Ala Thr Thr Asp Thr Leu Glu 575
580 585agc aca aca gtt ggc act tct gtc tag
aaaataataa ttgcaagttg 1825Ser Thr Thr Val Gly Thr Ser Val590
595tataactcag gcgtctttgc atttctgcga aagatcaagg tctgcaaggg
aattcttgtg 1885tgctgctttc catttgacac cgcagttctg ttcagccatc agaagagaga
caaggaatta 1945aaaatttctt tttaatcctg ttaccaaaaa aaaaaaaaaa aaa
198856597PRTHomo sapiens 56Met Ala Ala Val Gln Ala Ala Glu Val
Lys Val Asp Gly Ser Glu Pro1 5 10
15Lys Leu Ser Lys Asn Glu Leu Lys Arg Arg Leu Lys Ala Glu Lys
Lys 20 25 30Val Ala Glu Lys
Glu Ala Lys Gln Lys Glu Leu Ser Glu Lys Gln Leu 35
40 45Ser Gln Ala Thr Ala Ala Ala Thr Asn His Thr Thr
Asp Asn Gly Val 50 55 60Gly Pro Glu
Glu Glu Ser Val Asp Pro Asn Gln Tyr Tyr Lys Ile Arg65 70
75 80Ser Gln Ala Ile His Gln Leu Lys
Val Asn Gly Glu Asp Pro Tyr Pro 85 90
95His Lys Phe His Val Asp Ile Ser Leu Thr Asp Phe Ile Gln
Lys Tyr 100 105 110Ser His Leu
Gln Pro Gly Asp His Leu Thr Asp Ile Thr Leu Lys Val 115
120 125Ala Gly Arg Ile His Ala Lys Arg Ala Ser Gly
Gly Lys Leu Ile Phe 130 135 140Tyr Asp
Leu Arg Gly Glu Gly Val Lys Leu Gln Val Met Ala Asn Ser145
150 155 160Arg Asn Tyr Lys Ser Glu Glu
Glu Phe Ile His Ile Asn Asn Lys Leu 165
170 175Arg Arg Gly Asp Ile Ile Gly Val Gln Gly Asn Pro
Gly Lys Thr Lys 180 185 190Lys
Gly Glu Leu Ser Ile Ile Pro Tyr Glu Ile Thr Leu Leu Ser Pro 195
200 205Cys Leu His Met Leu Pro His Leu His
Phe Gly Leu Lys Asp Lys Glu 210 215
220Thr Arg Tyr Arg Gln Arg Tyr Leu Asp Leu Ile Leu Asn Asp Phe Val225
230 235 240Arg Gln Lys Phe
Ile Ile Arg Ser Lys Ile Ile Thr Tyr Ile Arg Ser 245
250 255Phe Leu Asp Glu Leu Gly Phe Leu Glu Ile
Glu Thr Pro Met Met Asn 260 265
270Ile Ile Pro Gly Gly Ala Val Ala Lys Pro Phe Ile Thr Tyr His Asn
275 280 285Glu Leu Asp Met Asn Leu Tyr
Met Arg Ile Ala Pro Glu Leu Tyr His 290 295
300Lys Met Leu Val Val Gly Gly Ile Asp Arg Val Tyr Glu Ile Gly
Arg305 310 315 320Gln Phe
Arg Asn Glu Gly Ile Asp Leu Thr His Asn Pro Glu Phe Thr
325 330 335Thr Cys Glu Phe Tyr Met Ala
Tyr Ala Asp Tyr His Asp Leu Met Glu 340 345
350Ile Thr Glu Lys Met Val Ser Gly Met Val Lys His Ile Thr
Gly Ser 355 360 365Tyr Lys Val Thr
Tyr His Pro Asp Gly Pro Glu Gly Gln Ala Tyr Asp 370
375 380Val Asp Phe Thr Pro Pro Phe Arg Arg Ile Asn Met
Val Glu Glu Leu385 390 395
400Glu Lys Ala Leu Gly Met Lys Leu Pro Glu Thr Asn Leu Phe Glu Thr
405 410 415Glu Glu Thr Arg Lys
Ile Leu Asp Asp Ile Cys Val Ala Lys Ala Val 420
425 430Glu Cys Pro Pro Pro Arg Thr Thr Ala Arg Leu Leu
Asp Lys Leu Val 435 440 445Gly Glu
Phe Leu Glu Val Thr Cys Ile Asn Pro Thr Phe Ile Cys Asp 450
455 460His Pro Gln Ile Met Ser Pro Leu Ala Lys Trp
His Arg Ser Lys Glu465 470 475
480Gly Leu Thr Glu Arg Phe Glu Leu Phe Val Met Lys Lys Glu Ile Cys
485 490 495Asn Ala Tyr Thr
Glu Leu Asn Asp Pro Met Arg Gln Arg Gln Leu Phe 500
505 510Glu Glu Gln Ala Lys Ala Lys Ala Ala Gly Asp
Asp Glu Ala Met Phe 515 520 525Ile
Asp Glu Asn Phe Cys Thr Ala Leu Glu Tyr Gly Leu Pro Pro Thr 530
535 540Ala Gly Trp Gly Met Gly Ile Asp Arg Val
Ala Met Phe Leu Thr Asp545 550 555
560Ser Asn Asn Ile Lys Glu Val Leu Leu Phe Pro Ala Met Lys Pro
Glu 565 570 575Asp Lys Lys
Glu Asn Val Ala Thr Thr Asp Thr Leu Glu Ser Thr Thr 580
585 590Val Gly Thr Ser Val
59557763DNAHomo sapiens 57ggggctaaac ctagccccaa acccactcca ccttactacc
agacaacctt agccaaacca 60tttacccaaa taaagtatag gcgatagaaa ttgaaacctg
gcgcaataga tatagtaccg 120caagggaaag atgaaaaatt ataaccaagc ataatatagc
aaggactaac ccctatacct 180tctgcataat gaattaacta gaaataactt tgcaaggaga
gccaaagcta agacccccga 240aaccagacga gctacctaag aacagctaaa agagcacacc
cgtctatgta gcaaaatagt 300gggaagattt ataggtagag gcgacaaacc taccgagcct
ggtgatagct ggttgtccaa 360gatagaatct tagttcaact ttaaatttgc ccacagaacc
ctctaaatcc ccttgtaaat 420ttaactgtta gtccaaagag gaacagctct ttggacacta
ggaaaaaacc ttgtagagag 480agtaaaaaat ttaacaccca tagtaggcct aaaagcagcc
accaattaag aaagcgttca 540agctcaacac ccactaccta aaaaatccca aacatataac
tgaactcctc acacccaatt 600ggaccaatct atcaccctat agaagaacta atgttagtat
aagtaacatg aaaacattct 660cctccgcata agcctgcgtc agattaaaac actgaactga
caattaacag cccaatatct 720acaatcaacc cacaagtcat tattaccctc actgtcaacc
caa 763581575DNAHomo sapiensCDS(196)..(834)
58ctcttcccgg ctccagctcc gccgccagct ccagcctttg ctccccctcc caaagtcccc
60tccccggagc ggagcgcacc tagggtccct cttccgtccc cccagcccag ctacccgttc
120agaccagcag cctcgggggg cacccccccg ccagcctgcc tccctcccgc tcagccctgc
180cagggttccc cagcc atg aat ctc ttc cga ttc ctg gga gac ctc tcc cac
231 Met Asn Leu Phe Arg Phe Leu Gly Asp Leu Ser His
1 5 10ctc ctc gcc atc atc ttg
cta ctg ctc aaa atc tgg aag tcc cgc tcg 279Leu Leu Ala Ile Ile Leu
Leu Leu Leu Lys Ile Trp Lys Ser Arg Ser 15 20
25tgc gcc gga att tca ggg aag agc cag gtc ctg ttt gct gtg
gtg ttc 327Cys Ala Gly Ile Ser Gly Lys Ser Gln Val Leu Phe Ala Val
Val Phe 30 35 40act gcc cga tat ctg
gac ctc ttc acc aac tac atc tca ctc tac aac 375Thr Ala Arg Tyr Leu
Asp Leu Phe Thr Asn Tyr Ile Ser Leu Tyr Asn45 50
55 60acg tgt atg aag gtg gtc tac ata gcc tgc
tcc ttc acc acg gtc tgg 423Thr Cys Met Lys Val Val Tyr Ile Ala Cys
Ser Phe Thr Thr Val Trp 65 70
75ttg att tat agc aag ttc aaa gct act tac gat ggg aac cat gac acg
471Leu Ile Tyr Ser Lys Phe Lys Ala Thr Tyr Asp Gly Asn His Asp Thr
80 85 90ttc aga gtg gag ttc ctg
gtc gtt ccc aca gcc att ctg gcg ttc ctg 519Phe Arg Val Glu Phe Leu
Val Val Pro Thr Ala Ile Leu Ala Phe Leu 95 100
105gtc aat cat gac ttc acc cct ctg gag atc ctc tgg acc ttc
tcc atc 567Val Asn His Asp Phe Thr Pro Leu Glu Ile Leu Trp Thr Phe
Ser Ile 110 115 120tac ctg gag tca gtg
gcc atc ttg ccg cag ctg ttc atg gtg agc aag 615Tyr Leu Glu Ser Val
Ala Ile Leu Pro Gln Leu Phe Met Val Ser Lys125 130
135 140acc ggc gag gcg gag acc atc acc agc cac
tac ttg ttt gcg cta ggc 663Thr Gly Glu Ala Glu Thr Ile Thr Ser His
Tyr Leu Phe Ala Leu Gly 145 150
155gtt tac cgc acg ctc tat ctc ttc aac tgg atc tgg cgc tac cat ttc
711Val Tyr Arg Thr Leu Tyr Leu Phe Asn Trp Ile Trp Arg Tyr His Phe
160 165 170gag ggc ttc ttc gac ctc
atc gcc att gtg gca ggc ctg gtc cag aca 759Glu Gly Phe Phe Asp Leu
Ile Ala Ile Val Ala Gly Leu Val Gln Thr 175 180
185gtc ctc tac tgc gat ttc ttc tac ctc tat atc acc aaa gtc
cta aag 807Val Leu Tyr Cys Asp Phe Phe Tyr Leu Tyr Ile Thr Lys Val
Leu Lys 190 195 200ggg aag aag ttg agt
ttg ccg gca tag ccccggtcct ctccatctct 854Gly Lys Lys Leu Ser
Leu Pro Ala205 210ctcctcggca gcagcgggag gcagaggaag
gcggcagaag atgaagagct ttcccatcca 914ggggtgactt ttttaagaac ccacctcttg
tgctccccat cccgcctcct gccgggtttc 974agggggacag tggaggatcc aggtcttggg
gagctcagga cttgggctgt ttgtagtttt 1034ttgcctttta gacaagaaaa aaaaatcttt
ccactcttta gtttttgatt ctgatgactc 1094gtttttcttc tactctgtgg ccccaatttt
tataaagtgt ttttgagtgt cctatgggcc 1154ggggcagggt ccaagatctt ttcccttccc
caggcccctc ggctccctcc cagatcccac 1214ccccagcccc actggttgcc aaacactaaa
tctgccgaca cccatctgcc ccacctcctg 1274ccatggccat gaaccgcgac ccccactaaa
tttctagatt ggggataggg agaaagggag 1334gcccaggaag gtctcccctg attttttttc
atagtaattt ttttccccag agtttgaatt 1394ttttggtctt ctcctggttt tttggcaaat
taggggggcc cggggctcaa gtgcgggaag 1454ggggctggcc cgaggatccc atggctctca
caccatgttt ttgtacagaa ctgatggttg 1514aatctttgtt ctcttgaaat aaacagaaga
aaatgaaacc tttaaaaaaa aaaaaaaaaa 1574a
157559212PRTHomo sapiens 59Met Asn Leu
Phe Arg Phe Leu Gly Asp Leu Ser His Leu Leu Ala Ile1 5
10 15Ile Leu Leu Leu Leu Lys Ile Trp Lys
Ser Arg Ser Cys Ala Gly Ile 20 25
30Ser Gly Lys Ser Gln Val Leu Phe Ala Val Val Phe Thr Ala Arg Tyr
35 40 45Leu Asp Leu Phe Thr Asn Tyr
Ile Ser Leu Tyr Asn Thr Cys Met Lys 50 55
60Val Val Tyr Ile Ala Cys Ser Phe Thr Thr Val Trp Leu Ile Tyr Ser65
70 75 80Lys Phe Lys Ala
Thr Tyr Asp Gly Asn His Asp Thr Phe Arg Val Glu 85
90 95Phe Leu Val Val Pro Thr Ala Ile Leu Ala
Phe Leu Val Asn His Asp 100 105
110Phe Thr Pro Leu Glu Ile Leu Trp Thr Phe Ser Ile Tyr Leu Glu Ser
115 120 125Val Ala Ile Leu Pro Gln Leu
Phe Met Val Ser Lys Thr Gly Glu Ala 130 135
140Glu Thr Ile Thr Ser His Tyr Leu Phe Ala Leu Gly Val Tyr Arg
Thr145 150 155 160Leu Tyr
Leu Phe Asn Trp Ile Trp Arg Tyr His Phe Glu Gly Phe Phe
165 170 175Asp Leu Ile Ala Ile Val Ala
Gly Leu Val Gln Thr Val Leu Tyr Cys 180 185
190Asp Phe Phe Tyr Leu Tyr Ile Thr Lys Val Leu Lys Gly Lys
Lys Leu 195 200 205Ser Leu Pro Ala
210602245DNAHomo sapiensCDS(157)..(1110) 60gaatctcgac ccttgaatgg
agttacacga acggccagat gaaagaagga aggcccggac 60ctccactcag ggccgactag
gggactggcg gagggtgcac gctgatggat ttactcaccg 120ggtgcttgga gctccagcag
ctggctggag cccgcg atg acg tca cgg act cgg 174
Met Thr Ser Arg Thr Arg
1 5gtc aca tgg ccg agt ccg ccc cgc ccc ctc ccc gtc ccc
gcc gct gca 222Val Thr Trp Pro Ser Pro Pro Arg Pro Leu Pro Val Pro
Ala Ala Ala 10 15 20gcc gtc
gcc ttc gga gcg aag ggt acc gac ccg gca gaa gct cgg agc 270Ala Val
Ala Phe Gly Ala Lys Gly Thr Asp Pro Ala Glu Ala Arg Ser 25
30 35tct cgg ggt atc gag gag gca ggc ccg cgg
gcg cac ggg cga gcg ggc 318Ser Arg Gly Ile Glu Glu Ala Gly Pro Arg
Ala His Gly Arg Ala Gly 40 45 50cgg
gag ccg gag cgg cgg agg agc cgg cag cag cgg cgc ggc ggg ctc 366Arg
Glu Pro Glu Arg Arg Arg Ser Arg Gln Gln Arg Arg Gly Gly Leu55
60 65 70cag gcg agg cgg tcg acg
ctc ctg aaa act tgc gcg cgc gct cgc gcc 414Gln Ala Arg Arg Ser Thr
Leu Leu Lys Thr Cys Ala Arg Ala Arg Ala 75
80 85act gcg ccc gga gcg atg aag atg gtc gcg ccc tgg
acg cgg ttc tac 462Thr Ala Pro Gly Ala Met Lys Met Val Ala Pro Trp
Thr Arg Phe Tyr 90 95 100tcc
aac agc tgc tgc ttg tgc tgc cat gtc cgc acc ggc acc atc ctg 510Ser
Asn Ser Cys Cys Leu Cys Cys His Val Arg Thr Gly Thr Ile Leu 105
110 115ctc ggc gtc tgg tat ctg atc atc aat
gct gtg gta ctg ttg att tta 558Leu Gly Val Trp Tyr Leu Ile Ile Asn
Ala Val Val Leu Leu Ile Leu 120 125
130ttg agt gcc ctg gct gat ccg gat cag tat aac ttt tca agt tct gaa
606Leu Ser Ala Leu Ala Asp Pro Asp Gln Tyr Asn Phe Ser Ser Ser Glu135
140 145 150ctg gga ggt gac
ttt gag ttc atg gat gat gcc aac atg tgc att gcc 654Leu Gly Gly Asp
Phe Glu Phe Met Asp Asp Ala Asn Met Cys Ile Ala 155
160 165att gcg att tct ctt ctc atg atc ctg ata
tgt gct atg gct act tac 702Ile Ala Ile Ser Leu Leu Met Ile Leu Ile
Cys Ala Met Ala Thr Tyr 170 175
180gga gcg tac aag caa cgc gca gcc tgg atc atc cca ttc ttc tgt tac
750Gly Ala Tyr Lys Gln Arg Ala Ala Trp Ile Ile Pro Phe Phe Cys Tyr
185 190 195cag atc ttt gac ttt gcc ctg
aac atg ttg gtt gca atc act gtg ctt 798Gln Ile Phe Asp Phe Ala Leu
Asn Met Leu Val Ala Ile Thr Val Leu 200 205
210att tat cca aac tcc att cag gaa tac ata cgg caa ctg cct cct aat
846Ile Tyr Pro Asn Ser Ile Gln Glu Tyr Ile Arg Gln Leu Pro Pro Asn215
220 225 230ttt ccc tac aga
gat gat gtc atg tca gtg aat cct acc tgt ttg gtc 894Phe Pro Tyr Arg
Asp Asp Val Met Ser Val Asn Pro Thr Cys Leu Val 235
240 245ctt att att ctt ctg ttt att agc att atc
ttg act ttt aag ggt tac 942Leu Ile Ile Leu Leu Phe Ile Ser Ile Ile
Leu Thr Phe Lys Gly Tyr 250 255
260ttg att agc tgt gtt tgg aac tgc tac cga tac atc aat ggt agg aac
990Leu Ile Ser Cys Val Trp Asn Cys Tyr Arg Tyr Ile Asn Gly Arg Asn
265 270 275tcc tct gat gtc ctg gtt tat
gtt acc agc aat gac act acg gtg ctg 1038Ser Ser Asp Val Leu Val Tyr
Val Thr Ser Asn Asp Thr Thr Val Leu 280 285
290cta ccc ccg tat gat gat gcc act gtg aat ggt gct gcc aag gag cca
1086Leu Pro Pro Tyr Asp Asp Ala Thr Val Asn Gly Ala Ala Lys Glu Pro295
300 305 310ccg cca cct tac
gtg tct gcc taa gccttcaagt gggcggagct gagggcagca 1140Pro Pro Pro Tyr
Val Ser Ala 315gcttgacttt gcagacatct gagcaatagt tctgttattt
cacttttgcc atgagcctct 1200ctgagcttgt ttgttgctga aatgctactt tttaaaattt
agatgttaga ttgaaaactg 1260tagttttcaa catatgcttt gctggaacac tgtgatagat
taactgtaga attcttcctg 1320tacgattggg gatataatgg gcttcactaa ccttccctag
gcattgaaac ttcccccaaa 1380tctgatggac ctagaagtct gcttttgtac ctgctgggcc
ccaaagttgg gcatttttct 1440ctctgttccc tctcttttga aaatgtaaaa taaaaccaaa
aatagacaac tttttcttca 1500gccattccag catagagaac aaaaccttat ggaaacagga
atgtcaattg tgtaatcatt 1560gttctaatta ggtaaataga agtccttatg tatgtgttac
aagaatttcc cccacaacat 1620cctttatgac tgaagttcaa tgacagtttg tgtttggtgg
taaaggattt tctccatggc 1680ctgaattaag accattagaa agcaccaggc cgtgggagca
gtgaccatct gctgactgtt 1740cttgtggatc ttgtgtccag ggacatgggg tgacatgcct
cgtatgtgtt agagggtgga 1800atggatgtgt ttggcgctgc atgggatctg gtgcccctct
tctcctggat tcacatcccc 1860acccagggcc cgcttttact aagtgttctg ccctagattg
gttcaaggag gtcatccaac 1920tgactttatc gagtggaatt gggatatatt tgatatactt
ctgcctaaca acatggaaaa 1980gggttttctt ttccctgcaa gctacatcct actgctttga
acttccaagt atgtctagtc 2040accttttaaa atgtaaacat tttcagaaaa atgaggattg
ccttccttgt atgcgctttt 2100taccttgact acctgaattg caagggattt ttatatattc
atatgttaca aagtcagcaa 2160ctctcctgtt ggttcattat tgaatgtgct gtaaattaag
ttgtttgcaa ttaaaacaag 2220gtttgcccac aaaaaaaaaa aaaaa
224561317PRTHomo sapiens 61Met Thr Ser Arg Thr Arg
Val Thr Trp Pro Ser Pro Pro Arg Pro Leu1 5
10 15Pro Val Pro Ala Ala Ala Ala Val Ala Phe Gly Ala
Lys Gly Thr Asp 20 25 30Pro
Ala Glu Ala Arg Ser Ser Arg Gly Ile Glu Glu Ala Gly Pro Arg 35
40 45Ala His Gly Arg Ala Gly Arg Glu Pro
Glu Arg Arg Arg Ser Arg Gln 50 55
60Gln Arg Arg Gly Gly Leu Gln Ala Arg Arg Ser Thr Leu Leu Lys Thr65
70 75 80Cys Ala Arg Ala Arg
Ala Thr Ala Pro Gly Ala Met Lys Met Val Ala 85
90 95Pro Trp Thr Arg Phe Tyr Ser Asn Ser Cys Cys
Leu Cys Cys His Val 100 105
110Arg Thr Gly Thr Ile Leu Leu Gly Val Trp Tyr Leu Ile Ile Asn Ala
115 120 125Val Val Leu Leu Ile Leu Leu
Ser Ala Leu Ala Asp Pro Asp Gln Tyr 130 135
140Asn Phe Ser Ser Ser Glu Leu Gly Gly Asp Phe Glu Phe Met Asp
Asp145 150 155 160Ala Asn
Met Cys Ile Ala Ile Ala Ile Ser Leu Leu Met Ile Leu Ile
165 170 175Cys Ala Met Ala Thr Tyr Gly
Ala Tyr Lys Gln Arg Ala Ala Trp Ile 180 185
190Ile Pro Phe Phe Cys Tyr Gln Ile Phe Asp Phe Ala Leu Asn
Met Leu 195 200 205Val Ala Ile Thr
Val Leu Ile Tyr Pro Asn Ser Ile Gln Glu Tyr Ile 210
215 220Arg Gln Leu Pro Pro Asn Phe Pro Tyr Arg Asp Asp
Val Met Ser Val225 230 235
240Asn Pro Thr Cys Leu Val Leu Ile Ile Leu Leu Phe Ile Ser Ile Ile
245 250 255Leu Thr Phe Lys Gly
Tyr Leu Ile Ser Cys Val Trp Asn Cys Tyr Arg 260
265 270Tyr Ile Asn Gly Arg Asn Ser Ser Asp Val Leu Val
Tyr Val Thr Ser 275 280 285Asn Asp
Thr Thr Val Leu Leu Pro Pro Tyr Asp Asp Ala Thr Val Asn 290
295 300Gly Ala Ala Lys Glu Pro Pro Pro Pro Tyr Val
Ser Ala305 310 315621453DNAHomo
sapiensCDS(65)..(1057) 62ggctgccgga gggcgggagg caggagcggg ccaggagctg
ctgggctgga gcggcggcgc 60cgcc atg tcc gac agc gag aag ctc aac ctg gac
tcg atc atc ggg cgc 109 Met Ser Asp Ser Glu Lys Leu Asn Leu Asp
Ser Ile Ile Gly Arg 1 5 10
15ctg ctg gaa gtg cag ggc tcg cgg cct ggc aag aat gta cag ctg aca
157Leu Leu Glu Val Gln Gly Ser Arg Pro Gly Lys Asn Val Gln Leu Thr
20 25 30gag aac gag atc cgc
ggt ctg tgc ctg aaa tcc cgg gag att ttt ctg 205Glu Asn Glu Ile Arg
Gly Leu Cys Leu Lys Ser Arg Glu Ile Phe Leu 35
40 45agc cag ccc att ctt ctg gag ctg gag gca ccc ctc
aag atc tgc ggt 253Ser Gln Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu
Lys Ile Cys Gly 50 55 60gac ata
cac ggc cag tac tac gac ctt ctg cga cta ttt gag tat ggc 301Asp Ile
His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe Glu Tyr Gly 65
70 75ggt ttc cct ccc gag agc aac tac ctc ttt ctg
ggg gac tat gtg gac 349Gly Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu
Gly Asp Tyr Val Asp80 85 90
95agg ggc aag cag tcc ttg gag acc atc tgc ctg ctg ctg gcc tat aag
397Arg Gly Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys
100 105 110atc aag tac ccc gag
aac ttc ttc ctg ctc cgt ggg aac cac gag tgt 445Ile Lys Tyr Pro Glu
Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys 115
120 125gcc agc atc aac cgc atc tat ggt ttc tac gat gag
tgc aag aga cgc 493Ala Ser Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu
Cys Lys Arg Arg 130 135 140tac aac
atc aaa ctg tgg aaa acc ttc act gac tgc ttc aac tgc ctg 541Tyr Asn
Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu 145
150 155ccc atc gcg gcc ata gtg gac gaa aag atc ttc
tgc tgc cac gga ggc 589Pro Ile Ala Ala Ile Val Asp Glu Lys Ile Phe
Cys Cys His Gly Gly160 165 170
175ctg tcc ccg gac ctg cag tct atg gag cag att cgg cgg atc atg cgg
637Leu Ser Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg
180 185 190ccc aca gat gtg cct
gac cag ggc ctg ctg tgt gac ctg ctg tgg tct 685Pro Thr Asp Val Pro
Asp Gln Gly Leu Leu Cys Asp Leu Leu Trp Ser 195
200 205gac cct gac aag gac gtg cag ggc tgg ggc gag aac
gac cgt ggc gtc 733Asp Pro Asp Lys Asp Val Gln Gly Trp Gly Glu Asn
Asp Arg Gly Val 210 215 220tct ttt
acc ttt gga gcc gag gtg gtg gcc aag ttc ctc cac aag cac 781Ser Phe
Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu His Lys His 225
230 235gac ttg gac ctc atc tgc cga gca cac cag gtg
gta gaa gac ggc tac 829Asp Leu Asp Leu Ile Cys Arg Ala His Gln Val
Val Glu Asp Gly Tyr240 245 250
255gag ttc ttt gcc aag cgg cag ctg gtg aca ctt ttc tca gct ccc aac
877Glu Phe Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn
260 265 270tac tgt ggc gag ttt
gac aat gct ggc gcc atg atg agt gtg gac gag 925Tyr Cys Gly Glu Phe
Asp Asn Ala Gly Ala Met Met Ser Val Asp Glu 275
280 285acc ctc atg tgc tct ttc cag atc ctc aag ccc gcc
gac aag aac aag 973Thr Leu Met Cys Ser Phe Gln Ile Leu Lys Pro Ala
Asp Lys Asn Lys 290 295 300ggg aag
tac ggg cag ttc agt ggc ctg aac cct gga ggc cga ccc atc 1021Gly Lys
Tyr Gly Gln Phe Ser Gly Leu Asn Pro Gly Gly Arg Pro Ile 305
310 315acc cca ccc cgc aat tcc gcc aaa gcc aag aaa
tag cccccgcaca 1067Thr Pro Pro Arg Asn Ser Ala Lys Ala Lys
Lys320 325 330ccaccctgtg ccccagatga
tggattgatt gtacagaaat catgctgcca tgctgggggg 1127gggtcacccc gacccctcag
gcccacctgt cacggggaac atggagcctt ggtgtatttt 1187tcttttcttt ttttaatgaa
tcaatagcag cgtccagtcc cccagggctg cttcctgcct 1247gcacctgcgg tgactgtgag
caggatcctg gggccgaggc tgcagctcag ggcaacggca 1307ggccaggtcg tgggtctcca
gccgtgcttg gcctcagggc tggcagccgg atcctggggc 1367aacccatctg gtctcttgaa
taaaggtcaa agctggattc tcaaaaaaaa aaaaaaaaaa 1427aaaaaaaaaa aaaaaaaaaa
aaaaaa 145363330PRTHomo sapiens
63Met Ser Asp Ser Glu Lys Leu Asn Leu Asp Ser Ile Ile Gly Arg Leu1
5 10 15Leu Glu Val Gln Gly Ser
Arg Pro Gly Lys Asn Val Gln Leu Thr Glu 20 25
30Asn Glu Ile Arg Gly Leu Cys Leu Lys Ser Arg Glu Ile
Phe Leu Ser 35 40 45Gln Pro Ile
Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp 50
55 60Ile His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe
Glu Tyr Gly Gly65 70 75
80Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg
85 90 95Gly Lys Gln Ser Leu Glu
Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile 100
105 110Lys Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn
His Glu Cys Ala 115 120 125Ser Ile
Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Tyr 130
135 140Asn Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys
Phe Asn Cys Leu Pro145 150 155
160Ile Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu
165 170 175Ser Pro Asp Leu
Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro 180
185 190Thr Asp Val Pro Asp Gln Gly Leu Leu Cys Asp
Leu Leu Trp Ser Asp 195 200 205Pro
Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser 210
215 220Phe Thr Phe Gly Ala Glu Val Val Ala Lys
Phe Leu His Lys His Asp225 230 235
240Leu Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr
Glu 245 250 255Phe Phe Ala
Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr 260
265 270Cys Gly Glu Phe Asp Asn Ala Gly Ala Met
Met Ser Val Asp Glu Thr 275 280
285Leu Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Asp Lys Asn Lys Gly 290
295 300Lys Tyr Gly Gln Phe Ser Gly Leu
Asn Pro Gly Gly Arg Pro Ile Thr305 310
315 320Pro Pro Arg Asn Ser Ala Lys Ala Lys Lys
325 330641591DNAHomo sapiensCDS(44)..(814)
64ccctgcgtct ctgcccgccc cgtggcgccc gagtgcactg aag atg gcg gct gct
55 Met Ala Ala Ala
1gta gga cgg ttg ctc cga gcg tcg
gtt gcc cga cat gtg agt gcc att 103Val Gly Arg Leu Leu Arg Ala Ser
Val Ala Arg His Val Ser Ala Ile5 10 15
20cct tgg ggc att tct gcc act gca gcc ctc agg cct gct
gca tgt gga 151Pro Trp Gly Ile Ser Ala Thr Ala Ala Leu Arg Pro Ala
Ala Cys Gly 25 30 35aga
acg agc ttg aca aat tta ttg tgt tct ggt tcc agt caa gca aaa 199Arg
Thr Ser Leu Thr Asn Leu Leu Cys Ser Gly Ser Ser Gln Ala Lys 40
45 50tta ttc agc acc agt tcc tca tgc
cat gca cct gct gtc acc cag cat 247Leu Phe Ser Thr Ser Ser Ser Cys
His Ala Pro Ala Val Thr Gln His 55 60
65gca ccc tat ttt aag ggt aca gcc gtt gtc aat gga gag ttc aaa gac
295Ala Pro Tyr Phe Lys Gly Thr Ala Val Val Asn Gly Glu Phe Lys Asp
70 75 80cta agc ctt gat gac ttt aag ggg
aaa tat ttg gtg ctt ttc ttc tat 343Leu Ser Leu Asp Asp Phe Lys Gly
Lys Tyr Leu Val Leu Phe Phe Tyr85 90 95
100cct ttg gat ttc acc ttt gtg tgt cct aca gaa att gtt
gct ttt agt 391Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile Val
Ala Phe Ser 105 110 115gac
aaa gct aac gaa ttt cac gac gtg aac tgt gaa gtt gtc gca gtc 439Asp
Lys Ala Asn Glu Phe His Asp Val Asn Cys Glu Val Val Ala Val
120 125 130tca gtg gat tcc cac ttt agc
cat ctt gcc tgg ata aat aca cca agg 487Ser Val Asp Ser His Phe Ser
His Leu Ala Trp Ile Asn Thr Pro Arg 135 140
145aag aat ggt ggt ttg ggc cac atg aac atc gca ctc ttg tca gac
tta 535Lys Asn Gly Gly Leu Gly His Met Asn Ile Ala Leu Leu Ser Asp
Leu 150 155 160act aag cag att tcc cga
gac tac ggt gtg ctg tta gaa ggt tct ggt 583Thr Lys Gln Ile Ser Arg
Asp Tyr Gly Val Leu Leu Glu Gly Ser Gly165 170
175 180ctt gca cta aga ggt ctc ttc ata att gac ccc
aat gga gtc atc aag 631Leu Ala Leu Arg Gly Leu Phe Ile Ile Asp Pro
Asn Gly Val Ile Lys 185 190
195cat ttg agc gtc aac gat ctc cca gtg ggc cga agc gtg gaa gaa acc
679His Leu Ser Val Asn Asp Leu Pro Val Gly Arg Ser Val Glu Glu Thr
200 205 210ctc cgc ttg gtg aag gcg
ttc cag tat gta gaa aca cat gga gaa gtc 727Leu Arg Leu Val Lys Ala
Phe Gln Tyr Val Glu Thr His Gly Glu Val 215 220
225tgc cca gcg aac tgg aca ccg gat tct cct acg atc aag cca
agt cca 775Cys Pro Ala Asn Trp Thr Pro Asp Ser Pro Thr Ile Lys Pro
Ser Pro 230 235 240gct gct tcc aaa gag
tac ttt cag aag gta aat cag tag atcacccatg 824Ala Ala Ser Lys Glu
Tyr Phe Gln Lys Val Asn Gln245 250
255tgtatctgca ccttctcaac tgagagaaga accacagttg aaacctgctt ttatcatttt
884caagatggtt atttgtagaa ggcaaggaac caattatgct tgtattcata agtattactc
944taaatgtttt gtttttgtaa ttctggctaa gaccttttaa acatggttag ttgctagtac
1004aaggaatcct ttattggtaa catcttggtg gctggctagc tagtttctac agaacataat
1064ttgcctctat agaaggctat tcttagatca tgtctcaatg gaaacactct tctttcttag
1124ccttacttga atcttgccta taataaagta gagcaacaca cattgaaagc ttctgatcaa
1184cggtcctgaa attttcatct tgaatgtctt tgtattaaac tgaattttct tttaagctaa
1244caaagatcat aattttcaat gattagccgt gtaactcctg caatgaatgt ttatgtgatt
1304gaagcaaatg tgaatcgtat tattttaaaa agtggcagag tgacttaact gatcatgcat
1364gatccctcat ccctgaaatt gagtttatgt agtcatttta cttattttat tcattagcta
1424actttgtcta tgtatatttc tagatattga ttagtgtaat cgattataaa ggatatttat
1484caaatccagg gattgcattt tgaaattata attattttct ttgctgaagt attcattgta
1544aaacatacaa aataaacata ttttaaaaca tttgcatttt accacca
159165256PRTHomo sapiens 65Met Ala Ala Ala Val Gly Arg Leu Leu Arg Ala
Ser Val Ala Arg His1 5 10
15Val Ser Ala Ile Pro Trp Gly Ile Ser Ala Thr Ala Ala Leu Arg Pro
20 25 30Ala Ala Cys Gly Arg Thr Ser
Leu Thr Asn Leu Leu Cys Ser Gly Ser 35 40
45Ser Gln Ala Lys Leu Phe Ser Thr Ser Ser Ser Cys His Ala Pro
Ala 50 55 60Val Thr Gln His Ala Pro
Tyr Phe Lys Gly Thr Ala Val Val Asn Gly65 70
75 80Glu Phe Lys Asp Leu Ser Leu Asp Asp Phe Lys
Gly Lys Tyr Leu Val 85 90
95Leu Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile
100 105 110Val Ala Phe Ser Asp Lys
Ala Asn Glu Phe His Asp Val Asn Cys Glu 115 120
125Val Val Ala Val Ser Val Asp Ser His Phe Ser His Leu Ala
Trp Ile 130 135 140Asn Thr Pro Arg Lys
Asn Gly Gly Leu Gly His Met Asn Ile Ala Leu145 150
155 160Leu Ser Asp Leu Thr Lys Gln Ile Ser Arg
Asp Tyr Gly Val Leu Leu 165 170
175Glu Gly Ser Gly Leu Ala Leu Arg Gly Leu Phe Ile Ile Asp Pro Asn
180 185 190Gly Val Ile Lys His
Leu Ser Val Asn Asp Leu Pro Val Gly Arg Ser 195
200 205Val Glu Glu Thr Leu Arg Leu Val Lys Ala Phe Gln
Tyr Val Glu Thr 210 215 220His Gly Glu
Val Cys Pro Ala Asn Trp Thr Pro Asp Ser Pro Thr Ile225
230 235 240Lys Pro Ser Pro Ala Ala Ser
Lys Glu Tyr Phe Gln Lys Val Asn Gln 245
250 255661224DNAHomo sapiensCDS(70)..(1041) 66gcccattgtt
tttgtaatct ctgaggagaa gcagcagcaa acatttgcta gtcagacaag 60tgacaggga
atg gat tcc aaa cac cag tgt gta aag cta aat gat ggc cac 111
Met Asp Ser Lys His Gln Cys Val Lys Leu Asn Asp Gly His 1
5 10ttc atg cct gta ttg gga ttt ggc acc tat gca
cct cca gag gtt ccg 159Phe Met Pro Val Leu Gly Phe Gly Thr Tyr Ala
Pro Pro Glu Val Pro15 20 25
30aga agt aaa gct ttg gag gtc aca aaa tta gca ata gaa gct ggg ttc
207Arg Ser Lys Ala Leu Glu Val Thr Lys Leu Ala Ile Glu Ala Gly Phe
35 40 45cgc cat ata gat tct
gct cat tta tac aat aat gag gag cag gtt gga 255Arg His Ile Asp Ser
Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly 50
55 60ctg gcc atc cga agc aag att gca gat ggc agt gtg
aag aga gaa gac 303Leu Ala Ile Arg Ser Lys Ile Ala Asp Gly Ser Val
Lys Arg Glu Asp 65 70 75ata ttc
tac act tca aag ctt tgg tcc act ttt cat cga cca gag ttg 351Ile Phe
Tyr Thr Ser Lys Leu Trp Ser Thr Phe His Arg Pro Glu Leu 80
85 90gtc cga cca gcc ttg gaa aac tca ctg aag aaa
gct caa ttg gac tat 399Val Arg Pro Ala Leu Glu Asn Ser Leu Lys Lys
Ala Gln Leu Asp Tyr95 100 105
110gtt gac ctc tat ctt att cat tct cca atg tct cta aag cca ggt gag
447Val Asp Leu Tyr Leu Ile His Ser Pro Met Ser Leu Lys Pro Gly Glu
115 120 125gaa ctt tca cca aca
gat gaa aat gga aaa gta ata ttt gac ata gtg 495Glu Leu Ser Pro Thr
Asp Glu Asn Gly Lys Val Ile Phe Asp Ile Val 130
135 140gat ctc tgt acc acc tgg gag gcc atg gag aag tgt
aag gat gca gga 543Asp Leu Cys Thr Thr Trp Glu Ala Met Glu Lys Cys
Lys Asp Ala Gly 145 150 155ttg gcc
aag tcc att ggg gtg tca aac ttc aac cgc agg cag ctg gag 591Leu Ala
Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu 160
165 170atg atc ctc aac aag cca gga ctc aag tac aag
cct gtc tgc aac cag 639Met Ile Leu Asn Lys Pro Gly Leu Lys Tyr Lys
Pro Val Cys Asn Gln175 180 185
190gta gaa tgt cat ccg tat ttc aac cgg agt aaa ttg cta gat ttc tgc
687Val Glu Cys His Pro Tyr Phe Asn Arg Ser Lys Leu Leu Asp Phe Cys
195 200 205aag tcg aaa gat att
gtt ctg gtt gcc tat agt gct ctg gga tct caa 735Lys Ser Lys Asp Ile
Val Leu Val Ala Tyr Ser Ala Leu Gly Ser Gln 210
215 220cga gac aaa cga tgg gtg gac ccg aac tcc ccg gtg
ctc ttg gag gac 783Arg Asp Lys Arg Trp Val Asp Pro Asn Ser Pro Val
Leu Leu Glu Asp 225 230 235cca gtc
ctt tgt gcc ttg gca aaa aag cac aag cga acc cca gcc ctg 831Pro Val
Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu 240
245 250att gcc ctg cgc tac cag ctg cag cgt ggg gtt
gtg gtc ctg gcc aag 879Ile Ala Leu Arg Tyr Gln Leu Gln Arg Gly Val
Val Val Leu Ala Lys255 260 265
270agc tac aat gag cag cgc atc aga cag aac gtg cag gtt ttt gag ttc
927Ser Tyr Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe
275 280 285cag ttg act gca gag
gac atg aaa gcc ata gat ggc cta gac aga aat 975Gln Leu Thr Ala Glu
Asp Met Lys Ala Ile Asp Gly Leu Asp Arg Asn 290
295 300ctc cac tat ttt aac agt gat agt ttt gct agc cac
cct aat tat cca 1023Leu His Tyr Phe Asn Ser Asp Ser Phe Ala Ser His
Pro Asn Tyr Pro 305 310 315tat tca
gat gaa tat taa catggagggc tttgcctgat gtctaccaga 1071Tyr Ser
Asp Glu Tyr 320agccctgtgt gtggatggtg acgcagagga cgtctctatg ccggtgactg
gacatatcac 1131ctctacttaa atccgtcctg tttagcgact tcagtcaact acagctgagt
ccataggcca 1191gaaagacaat aaatttttat cattttgaaa taa
122467323PRTHomo sapiens 67Met Asp Ser Lys His Gln Cys Val Lys
Leu Asn Asp Gly His Phe Met1 5 10
15Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Pro Glu Val Pro Arg
Ser 20 25 30Lys Ala Leu Glu
Val Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 35
40 45Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln
Val Gly Leu Ala 50 55 60Ile Arg Ser
Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe65 70
75 80Tyr Thr Ser Lys Leu Trp Ser Thr
Phe His Arg Pro Glu Leu Val Arg 85 90
95Pro Ala Leu Glu Asn Ser Leu Lys Lys Ala Gln Leu Asp Tyr
Val Asp 100 105 110Leu Tyr Leu
Ile His Ser Pro Met Ser Leu Lys Pro Gly Glu Glu Leu 115
120 125Ser Pro Thr Asp Glu Asn Gly Lys Val Ile Phe
Asp Ile Val Asp Leu 130 135 140Cys Thr
Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala145
150 155 160Lys Ser Ile Gly Val Ser Asn
Phe Asn Arg Arg Gln Leu Glu Met Ile 165
170 175Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys
Asn Gln Val Glu 180 185 190Cys
His Pro Tyr Phe Asn Arg Ser Lys Leu Leu Asp Phe Cys Lys Ser 195
200 205Lys Asp Ile Val Leu Val Ala Tyr Ser
Ala Leu Gly Ser Gln Arg Asp 210 215
220Lys Arg Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val225
230 235 240Leu Cys Ala Leu
Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 245
250 255Leu Arg Tyr Gln Leu Gln Arg Gly Val Val
Val Leu Ala Lys Ser Tyr 260 265
270Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu
275 280 285Thr Ala Glu Asp Met Lys Ala
Ile Asp Gly Leu Asp Arg Asn Leu His 290 295
300Tyr Phe Asn Ser Asp Ser Phe Ala Ser His Pro Asn Tyr Pro Tyr
Ser305 310 315 320Asp Glu
Tyr681715DNAHomo sapiensCDS(37)..(591) 68ccgtgctctg cctcctgtgt tccagggact
ttgaac atg tcg ggg atc gcc ctc 54
Met Ser Gly Ile Ala Leu 1
5agc aga ctc gcc cag gag agg aaa gca tgg agg aaa gac cac cca
ttt 102Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp Arg Lys Asp His Pro
Phe 10 15 20ggt ttc gtg gct
gtc cca aca aaa aat ccc gat ggc acg atg aac ctc 150Gly Phe Val Ala
Val Pro Thr Lys Asn Pro Asp Gly Thr Met Asn Leu 25
30 35atg aac tgg gag tgc gcc att cca gga aag aaa ggg
act ccg tgg gaa 198Met Asn Trp Glu Cys Ala Ile Pro Gly Lys Lys Gly
Thr Pro Trp Glu 40 45 50gga ggc ttg
ttt aaa cta cgg atg ctt ttc aaa gat gat tat cca tct 246Gly Gly Leu
Phe Lys Leu Arg Met Leu Phe Lys Asp Asp Tyr Pro Ser55 60
65 70tcg cca cca aaa tgt aaa ttc gaa
cca cca tta ttt cac ccg aat gtg 294Ser Pro Pro Lys Cys Lys Phe Glu
Pro Pro Leu Phe His Pro Asn Val 75 80
85tac cct tcg ggg aca gtg tgc ctg tcc atc tta gag gag gac
aag gac 342Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile Leu Glu Glu Asp
Lys Asp 90 95 100tgg agg cca
gcc atc aca atc aaa cag atc cta tta gga ata cag gaa 390Trp Arg Pro
Ala Ile Thr Ile Lys Gln Ile Leu Leu Gly Ile Gln Glu 105
110 115ctt cta aat gaa cca aat atc caa gac cca gct
caa gca gag gcc tac 438Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro Ala
Gln Ala Glu Ala Tyr 120 125 130acg att
tac tgg tta gta gca gcc ctg gcc ccg ctg gtg gca gct cct 486Thr Ile
Tyr Trp Leu Val Ala Ala Leu Ala Pro Leu Val Ala Ala Pro135
140 145 150ccc cgt ccc agc caa ggc cgc
ctg gca gga cgg gag tgg agc aca cag 534Pro Arg Pro Ser Gln Gly Arg
Leu Ala Gly Arg Glu Trp Ser Thr Gln 155
160 165gct cac cct agg gac agc cag ggt ccg cgc ctc tgt
ggg gaa ggt cgg 582Ala His Pro Arg Asp Ser Gln Gly Pro Arg Leu Cys
Gly Glu Gly Arg 170 175 180ggg
gca taa accctgtggg cagcaggcac cgttgcacac cgtctgcggt 631Gly
Alagggcatggat ggcgccggag ccgtgtccag gggagggagc aggccaggtg acaggggctg
691tcttgggcca ctgccccagt gagttgtggc cagctaggag gggaaggacc ctgggcgtgg
751gtgccagagg aggccatgct gagaggcctc tccaccggct cagcctcccg tggaccccag
811cctcccgcgc cgcccttgct gcttgtcccc atcccctcta caacttggtt ccttctgtgg
871gggggcccag cccagcaggg ctcagtgacg tgatgctgtc acacggaccc tgggcttcca
931ccctgtccct gtgaggtgct gctgtggcta gaagggtccc cgtgggcctg gggtcctgtc
991tgcaccgagg agggcctggt gtgagttagg atgcagacga cagccaaaca gtgctgggga
1051aagcagggag gaccctgccc tgagcagagg ccatgcgccc gcctgtcctg ttccctctgc
1111agctgttctg ggcaggtcca taagaaggtg ggttggggcc tccgaccccc actgctccgc
1171ctgcagggtt gagaaaccca gccccatctc accacgggtc cccacacctc tgaggaggtc
1231tcagggcccc caatggccag ggacccagaa ggctcacctg cagccacccc acacatccct
1291gccactgtgg gcatcagagg ccctctccct ccagggtgca tctcctggtc aggagggggg
1351aggcccggtt gccttaggcc cggcctgcac aggtcgtgag gaaaagcacc tggtttcggc
1411cgggcgcggt ggctcacgct tgtaatccca gcactttggg aggccgaggt gggcgaatca
1471tgcggtcagg agttcgagac cagcctggcc aacatggcga aaccctcgtc cctactaaaa
1531atacaaaaaa ttagttgggc gtagtggtgg gtgcctctaa tcccagctac ctgggaggct
1591gagacaggag aatcacttga acccgggagg cggaggttgc agtgagccga gatcctgcca
1651ctgctctcca gcctggcgac ggaggaatgc tgtctcaaaa aaaaaaaaaa aaaaaaaaaa
1711aaaa
171569184PRTHomo sapiens 69Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln
Glu Arg Lys Ala Trp1 5 10
15Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro
20 25 30Asp Gly Thr Met Asn Leu Met
Asn Trp Glu Cys Ala Ile Pro Gly Lys 35 40
45Lys Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu
Phe 50 55 60Lys Asp Asp Tyr Pro Ser
Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro65 70
75 80Leu Phe His Pro Asn Val Tyr Pro Ser Gly Thr
Val Cys Leu Ser Ile 85 90
95Leu Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile
100 105 110Leu Leu Gly Ile Gln Glu
Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro 115 120
125Ala Gln Ala Glu Ala Tyr Thr Ile Tyr Trp Leu Val Ala Ala
Leu Ala 130 135 140Pro Leu Val Ala Ala
Pro Pro Arg Pro Ser Gln Gly Arg Leu Ala Gly145 150
155 160Arg Glu Trp Ser Thr Gln Ala His Pro Arg
Asp Ser Gln Gly Pro Arg 165 170
175Leu Cys Gly Glu Gly Arg Gly Ala 180701327DNAHomo
sapiensCDS(100)..(966) 70ctcctctccg cgcggggcgg gctccgcgcc acgtgactcc
gcggccgggc cgggacgcga 60cgggacgcgc tgggaccggc gtcgggggtc gcggggacc
atg cag cgg agg tgg 114
Met Gln Arg Arg Trp 1
5gtc ttc gtg ctg ctc gac gtg ctg tgc tta ctg gtc gcc tcc ctg ccc
162Val Phe Val Leu Leu Asp Val Leu Cys Leu Leu Val Ala Ser Leu Pro
10 15 20ttc gct atc ctg acg ctg gtg
aac gcc ccg tac aag cga gga ttt tac 210Phe Ala Ile Leu Thr Leu Val
Asn Ala Pro Tyr Lys Arg Gly Phe Tyr 25 30
35tgc ggg gat gac tcc atc cgg tac ccc tac cgt cca gat acc atc
acc 258Cys Gly Asp Asp Ser Ile Arg Tyr Pro Tyr Arg Pro Asp Thr Ile
Thr 40 45 50cac ggg ctc atg gct ggg
gtc acc atc acg gcc acc gtc atc ctt gtc 306His Gly Leu Met Ala Gly
Val Thr Ile Thr Ala Thr Val Ile Leu Val55 60
65tcg gcc ggg gaa gcc tac ctg gtg tac aca gac cgg ctc tat tct cgc
354Ser Ala Gly Glu Ala Tyr Leu Val Tyr Thr Asp Arg Leu Tyr Ser Arg70
75 80 85tcg gac ttc aac
aac tac gtg gct gct gta tac aag gtg ctg ggg acc 402Ser Asp Phe Asn
Asn Tyr Val Ala Ala Val Tyr Lys Val Leu Gly Thr 90
95 100ttc ctg ttt ggg gct gcc gtg agc cag tct
ctg aca gac ctg gcc aag 450Phe Leu Phe Gly Ala Ala Val Ser Gln Ser
Leu Thr Asp Leu Ala Lys 105 110
115tac atg att ggg cgt ctg agg ccc aac ttc cta gcc gtc tgc gac ccc
498Tyr Met Ile Gly Arg Leu Arg Pro Asn Phe Leu Ala Val Cys Asp Pro
120 125 130gac tgg agc cgg gtc aac tgc
tcg gtc tat gtg cag ctg gag aag gtg 546Asp Trp Ser Arg Val Asn Cys
Ser Val Tyr Val Gln Leu Glu Lys Val 135 140
145tgc agg gga aac cct gct gat gtc acc gag gcc agg ttg tct ttc tac
594Cys Arg Gly Asn Pro Ala Asp Val Thr Glu Ala Arg Leu Ser Phe Tyr150
155 160 165tcg gga cac tct
tcc ttt ggg atg tac tgc atg gtg ttc ttg gcg ctg 642Ser Gly His Ser
Ser Phe Gly Met Tyr Cys Met Val Phe Leu Ala Leu 170
175 180tat gtg cag gca cga ctc tgt tgg aag tgg
gca cgg ctg ctg cga ccc 690Tyr Val Gln Ala Arg Leu Cys Trp Lys Trp
Ala Arg Leu Leu Arg Pro 185 190
195aca gtc cag ttc ttc ctg gtg gcc ttt gcc ctc tac gtg ggc tac acc
738Thr Val Gln Phe Phe Leu Val Ala Phe Ala Leu Tyr Val Gly Tyr Thr
200 205 210cgc gtg tct gat tac aaa cac
cac tgg agc gat gtc ctt gtt ggc ctc 786Arg Val Ser Asp Tyr Lys His
His Trp Ser Asp Val Leu Val Gly Leu 215 220
225ctg cag ggg gca ctg gtg gct gcc ctc act gtc tgc tac atc tca gac
834Leu Gln Gly Ala Leu Val Ala Ala Leu Thr Val Cys Tyr Ile Ser Asp230
235 240 245ttc ttc aaa gcc
cga ccc cca cag cac tgt ctg aag gag gag gag ctg 882Phe Phe Lys Ala
Arg Pro Pro Gln His Cys Leu Lys Glu Glu Glu Leu 250
255 260gaa cgg aag ccc agc ctg tca ctg acg ttg
acc ctg ggc gag gct gac 930Glu Arg Lys Pro Ser Leu Ser Leu Thr Leu
Thr Leu Gly Glu Ala Asp 265 270
275cac aac cac tat gga tac ccg cac tcc tcc tcc tga ggccggaccc
976His Asn His Tyr Gly Tyr Pro His Ser Ser Ser 280
285cgcccaggca gggagctgct gtgagtccag ctgaggccca cccaggtggt ccctccagcc
1036ctggttaggc actgagggct ctggacgggc tccaggaacc ctgggctgat gggagcagtg
1096agcgggctcc gctgccccct gccctgcact ggaccaggag tctggagatg cctgggtagc
1156cctcagcatt tggaggggaa cctgttcccg tcggtcccca aatatcccct tctttttatg
1216gggttaagga agggaccgag agatcagata gttgctgttt tgtaaaatgt aatgtatatg
1276tggtttttag taaaataggg cacctgtttc acaaaaaaaa aaaaaaaaaa a
132771288PRTHomo sapiens 71Met Gln Arg Arg Trp Val Phe Val Leu Leu Asp
Val Leu Cys Leu Leu1 5 10
15Val Ala Ser Leu Pro Phe Ala Ile Leu Thr Leu Val Asn Ala Pro Tyr
20 25 30Lys Arg Gly Phe Tyr Cys Gly
Asp Asp Ser Ile Arg Tyr Pro Tyr Arg 35 40
45Pro Asp Thr Ile Thr His Gly Leu Met Ala Gly Val Thr Ile Thr
Ala 50 55 60Thr Val Ile Leu Val Ser
Ala Gly Glu Ala Tyr Leu Val Tyr Thr Asp65 70
75 80Arg Leu Tyr Ser Arg Ser Asp Phe Asn Asn Tyr
Val Ala Ala Val Tyr 85 90
95Lys Val Leu Gly Thr Phe Leu Phe Gly Ala Ala Val Ser Gln Ser Leu
100 105 110Thr Asp Leu Ala Lys Tyr
Met Ile Gly Arg Leu Arg Pro Asn Phe Leu 115 120
125Ala Val Cys Asp Pro Asp Trp Ser Arg Val Asn Cys Ser Val
Tyr Val 130 135 140Gln Leu Glu Lys Val
Cys Arg Gly Asn Pro Ala Asp Val Thr Glu Ala145 150
155 160Arg Leu Ser Phe Tyr Ser Gly His Ser Ser
Phe Gly Met Tyr Cys Met 165 170
175Val Phe Leu Ala Leu Tyr Val Gln Ala Arg Leu Cys Trp Lys Trp Ala
180 185 190Arg Leu Leu Arg Pro
Thr Val Gln Phe Phe Leu Val Ala Phe Ala Leu 195
200 205Tyr Val Gly Tyr Thr Arg Val Ser Asp Tyr Lys His
His Trp Ser Asp 210 215 220Val Leu Val
Gly Leu Leu Gln Gly Ala Leu Val Ala Ala Leu Thr Val225
230 235 240Cys Tyr Ile Ser Asp Phe Phe
Lys Ala Arg Pro Pro Gln His Cys Leu 245
250 255Lys Glu Glu Glu Leu Glu Arg Lys Pro Ser Leu Ser
Leu Thr Leu Thr 260 265 270Leu
Gly Glu Ala Asp His Asn His Tyr Gly Tyr Pro His Ser Ser Ser 275
280 285722980DNAHomo
sapiensCDS(274)..(519)misc_feature(2974)..(2974)n = a, t, g or c
72ggccgctcct gctgctgcta ctgccgccgc cgcagcggct gctcgggctg agcacgcccc
60ggaacaggcc gccgcgcgct gcgcgccgga cccgctgccc ctgccggccc ggccgggtcg
120ggcggcccag ggaccgacag acttgacaac ggtgacagca ctggggcggc accttcctac
180ttctgcccag ccacagccct cccctcacag ttgagcacct gtttgcctga agttaatttc
240cagaagcagg agtccccaga gccaggcagg ggg atg aac cgc gag gga gct ccc
294 Met Asn Arg Glu Gly Ala Pro
1 5ggg aag agt ccg gag gag
atg tac att cag cag aag gtc cga gtg ctg 342Gly Lys Ser Pro Glu Glu
Met Tyr Ile Gln Gln Lys Val Arg Val Leu 10 15
20ctc atg ctg cgg aag atg gga tca aac ctg aca gcc agc gag
gag gag 390Leu Met Leu Arg Lys Met Gly Ser Asn Leu Thr Ala Ser Glu
Glu Glu 25 30 35ttc ctg cgc acc tat
gca ggg gtg gtc aac agc cag ctc agc cag ctg 438Phe Leu Arg Thr Tyr
Ala Gly Val Val Asn Ser Gln Leu Ser Gln Leu40 45
50 55cct ccg cac tcc atc gac cag ggt gca gag
gac gtg gtg atg gcg ttt 486Pro Pro His Ser Ile Asp Gln Gly Ala Glu
Asp Val Val Met Ala Phe 60 65
70tcc agg tcg gag acg gaa gac cgg agg cag tag ctgcaaagcc cttggaacac
539Ser Arg Ser Glu Thr Glu Asp Arg Arg Gln 75
80cctggatgct gttgaagggc caagagatct gtgtggctcc tgggccggct gaatggcagc
599agcccccctt gccccacctc ccccttccct acccaaccct gccctgcccc accccacctc
659acagctactc agtggggctg gcatcaaggg agacaccagt ggtgcgttta taattggctt
719aaagggatgg acttgtgatt ggctgcagga agaaactttt ttatttttta aatcttgacc
779aacagaaacc ttttattttt atttctgact cttatttttt aaaaaatttg cgcctcggta
839tctggcttcc ctggaagctc tccgagctct ggtgctttag ttaggtcatt tttttagaaa
899tgtgaagagg tctgattggc tgcttaaact ggaaagggac tgtgattggc tggttaatgg
959gaaacggttt ttttctttgg ctgcaggtgt tctgctgata tcaacagctt ccctattttg
1019aatgcagaaa acagggtctg ggacattagt cgttatattt gacttgaaaa gaaagaaacc
1079aagtgcgctt tgcaatattt attacacaaa gaacttgctg ctgccttcac atttggggtt
1139tgtgtttgat tggctttcga tgcgtgtgtt tggtttccca ttggttcacc tgtgactcct
1199gttgccatgg attcaccccc ctctgctgcc ggctctgggc ctgagggtcc acctggagag
1259tacatttgct ttaatgagtg cacctgcctc caccagcaag gggaccccga gaaccctgag
1319cagggtccac agctggaaag ttgggcccct gaggagcttt gtgtcgtctt gaacgagcag
1379cccagggcct agaggtaacc gttaggcggg atttatgtgc actgcctgca tgagctggca
1439accagccagc gtcccttggt gagaaaggga ttgctgaggc accgtccagg ccccaccggc
1499caggccgcgc ccagcagagg cgtactaccc agctctgtcc tcttggccat ccttctgtgt
1559accacttcct gaggcctcat tttgggggtc atcttggaaa ggggaggagc ttctcccagt
1619gtgagacccc aaagactctg gaggtcatct ggcggaggtc tctgggagcc cagaacccac
1679ataaaagccc cagcttggct cacaaggccc aggagacctc cagctaaaca ccaacccctg
1739acctacccca gccaggctcc tacctgtctg ctgccagcac agtaggtccc ggccagctct
1799ggagttctct catcggaggc ccatgccctc cactccactg cctttggaag ggtctctctc
1859caggtcagcc tggaagggac agtatcgttt gtttatgaaa tgccactggg acagctggct
1919gggccttcac caagcaagtc ccttcagact ggcccttaag ccaaactcag gcccagaatt
1979gcagttcaga atggcagtcc tggaggcagg gggtgagggg caggtctagt gttcctgcac
2039caaacctaag tccttccacc tgccaccccc ttccctggga gggaggtggt cctcctatct
2099ccctggctca ctggcaggtg tgggatctgg ggagagcggc tggagaaaga tgcagtcctc
2159aggaaggggg ccgccaccct cccctatgct ggtagatgct gaggccccta ggtgcccagg
2219gccagtggga ccctctcaga accaaatctt tcccctttct cggggcttgg ggctcgggcc
2279gtaggggctc ctgagtgtca tgaagtgcac aggagccaaa tgaccgagcc ctggagagcc
2339ccatggtggg taggtggttc gtgctgtgct ctggcaccat cagcctgttc cagaaggagg
2399attcgagcat caggctaaga ccctgtgtcc tccaccatgc actcacccct agccctggtt
2459agctgacagt cagctgtggg gaacacagct acaaccctac cctggcaggg acctgagagc
2519atctcaggag gggcagcgca tgtgtgcatg tgctgtgtga gtgagcacac ccgtgtgcac
2579actcatacac atgtgcacac acacgcactc tccccgctca ggggcctgga ggtctggctg
2639agcccctggg gaaaggtgag ttctttcatc tccctcctcc aggtcggagt gcctggagtc
2699aggtgtcgag gccacattgc tggctgcccc ctctttgtag ctcctataaa gggcccacac
2759ctggtggata cctggttgag cgtgtggtct ctgccccagc ctgtccttgt cacgatcaca
2819ggccttgctt ttgtaacaat gatgaccccg gcctgtctca tcttctgaag aggaaaagtc
2879aaagtgttgc tgtggctcca tatttcaact aaaaatatat ctgttggaga aagaaattaa
2939caataaagaa ttttcatagg ttaaaaaaaa aaaanaaaaa g
29807381PRTHomo sapiens 73Met Asn Arg Glu Gly Ala Pro Gly Lys Ser Pro Glu
Glu Met Tyr Ile1 5 10
15Gln Gln Lys Val Arg Val Leu Leu Met Leu Arg Lys Met Gly Ser Asn
20 25 30Leu Thr Ala Ser Glu Glu Glu
Phe Leu Arg Thr Tyr Ala Gly Val Val 35 40
45Asn Ser Gln Leu Ser Gln Leu Pro Pro His Ser Ile Asp Gln Gly
Ala 50 55 60Glu Asp Val Val Met Ala
Phe Ser Arg Ser Glu Thr Glu Asp Arg Arg65 70
75 80Gln742153DNAHomo sapiensCDS(589)..(1356)
74cagcggccgg gagggggctc cggggaccat ggggctcctg accattctga agaagatgaa
60gcagaaagag cgggagctgc gactgctcat gcttggcctg gacaatgctg gaaagacaac
120catcctgaag aagttcaatg gggaggacat cgacaccatc tccccaacgc tgggcttcaa
180catcaagacc ctggagcacc gaggattcaa gctgaacatc tgggatgtgg gtggccagaa
240gtccctgcgg tcctactggc ggaactactt tgagagcacc gatggcctca tctgggtagt
300ggacagcgca gaccgccagc gcatgcagga ctgccagcgg gagctccaga gcctgctggt
360ggaggagtga cctgggttta cgcttcacca cagagaagga acttttcaga cgctcccttg
420gccgcgcacc cgggatcgga acagcgctgt cacttgcgac aaaatcccta ggccagagga
480agaagagcgc aggcctgggc gaggcggcgg cgggcggagg ctgggccgga ggggtgggga
540cggcgaggag gtggaggccg gcgctccgct ccgctccagc tcggtttc atg tcc cgc
597 Met Ser Arg
1cag gcg aag gat gac ttc
ctg cgg cac tac aca gtg tcg gac ccc agg 645Gln Ala Lys Asp Asp Phe
Leu Arg His Tyr Thr Val Ser Asp Pro Arg 5 10
15act cac ccc aag ggc tac acc gag tac aaa gta acc gcg cag ttc
atc 693Thr His Pro Lys Gly Tyr Thr Glu Tyr Lys Val Thr Ala Gln Phe
Ile20 25 30 35tca aag
aag gac cca gag gat gtc aaa gag gtg gtg gtc tgg aag cgg 741Ser Lys
Lys Asp Pro Glu Asp Val Lys Glu Val Val Val Trp Lys Arg 40
45 50tac agc gac ttc cgc aag ctg cat
gga gac ctg gcc tac acc cac cgc 789Tyr Ser Asp Phe Arg Lys Leu His
Gly Asp Leu Ala Tyr Thr His Arg 55 60
65aac ctc ttc cgc cgc ctc gag gag ttc cct gct ttc ccc cgg gcc
cag 837Asn Leu Phe Arg Arg Leu Glu Glu Phe Pro Ala Phe Pro Arg Ala
Gln 70 75 80gtg ttt ggc cgg ttt
gaa gcc tca gtg atc gag gag cgg cga aag ggg 885Val Phe Gly Arg Phe
Glu Ala Ser Val Ile Glu Glu Arg Arg Lys Gly 85 90
95gca gag gac ctg ctt cgc ttc act gtg cac ata cct gcg ctc
aac aac 933Ala Glu Asp Leu Leu Arg Phe Thr Val His Ile Pro Ala Leu
Asn Asn100 105 110 115agc
ccc cag ctc aag gag ttc ttc cgg ggt ggg gag gtg acc cga ccc 981Ser
Pro Gln Leu Lys Glu Phe Phe Arg Gly Gly Glu Val Thr Arg Pro
120 125 130ttg gag gtg tcc agg gac cta
cac atc ctg cca ccc cct ctg atc ccc 1029Leu Glu Val Ser Arg Asp Leu
His Ile Leu Pro Pro Pro Leu Ile Pro 135 140
145acc ccg ccc cct gat gac ccc cgg cta tcc caa ctg ctc cct
gca gaa 1077Thr Pro Pro Pro Asp Asp Pro Arg Leu Ser Gln Leu Leu Pro
Ala Glu 150 155 160agg agg ggc ctc
gag gaa ttg gag gtg cca gtg gac ccc cca cca tcc 1125Arg Arg Gly Leu
Glu Glu Leu Glu Val Pro Val Asp Pro Pro Pro Ser 165
170 175agc cct gcc cag gag gcc ctg gat ctc ctc ttt aac
tgt gag agc acc 1173Ser Pro Ala Gln Glu Ala Leu Asp Leu Leu Phe Asn
Cys Glu Ser Thr180 185 190
195gag gag gca tct ggt tcc cct gcc cga ggc ccc ctc acc gag gct gag
1221Glu Glu Ala Ser Gly Ser Pro Ala Arg Gly Pro Leu Thr Glu Ala Glu
200 205 210ctt gcc ctc ttc gac
ccc ttc tcc aag ggt gac ccg ttg cct gcc cgc 1269Leu Ala Leu Phe Asp
Pro Phe Ser Lys Gly Asp Pro Leu Pro Ala Arg 215
220 225cag gaa ggt gtg aag aag aag gca gct gag tac ctg
aag cgg gca gag 1317Gln Glu Gly Val Lys Lys Lys Ala Ala Glu Tyr Leu
Lys Arg Ala Glu 230 235 240gag atc
ctg cgc ctg cac ctg tct caa ctc cca ccc taa cagggagtgg 1366Glu Ile
Leu Arg Leu His Leu Ser Gln Leu Pro Pro 245 250
255gccattccct gggactctca ctcctgcact gccagcccct tctcctctcc
ccagggcctg 1426gccctacctc ctggtcttgt aattacagga gccatttctg taggtaactg
gaccaagaat 1486gagaaaaata atgaattctt agctccctga ttacacctgc caccttggaa
tccaggactc 1546acacttctga ccctgcctgt ctttttgggg tttttttgag ttggagtctc
gctgtgtcgc 1606ccagactgga gtgcagtggt gggatcgcgg ctcactgcaa cctccacctc
ccaggttcaa 1666gcagttctcc tgtctcagcc tccccagtag ctgagattgc aggcacatgc
caccacgccc 1726agctaatatt ttgtattttc agtagggacg gggttacacc atgttggcca
ggctggtctc 1786gaactcctga cctcaagtga tccacccgcc tcagtctccc aaagtgctga
gattacaggc 1846atgagtcact acgcccggcc catgtctgtc tgtcttgatg tgtgagcagc
agctgtggtc 1906attaaaccat tagtttaccc ctctagaact ggggtctgca aactcccacc
tgcagccaaa 1966tctggcccac ctccttttta atgtaagggc tgtgagagtg gtttttactt
tttttaatga 2026ttaaaaaaat caaaataata ttctgtgaca atgacaggtg aaatttatat
gtgacaagtg 2086aaaattatat gaaatttaag agtccataaa taaaatttgt tggaacacaa
aaaaaaaaaa 2146aaaaaaa
215375255PRTHomo sapiens 75Met Ser Arg Gln Ala Lys Asp Asp Phe
Leu Arg His Tyr Thr Val Ser1 5 10
15Asp Pro Arg Thr His Pro Lys Gly Tyr Thr Glu Tyr Lys Val Thr
Ala 20 25 30Gln Phe Ile Ser
Lys Lys Asp Pro Glu Asp Val Lys Glu Val Val Val 35
40 45Trp Lys Arg Tyr Ser Asp Phe Arg Lys Leu His Gly
Asp Leu Ala Tyr 50 55 60Thr His Arg
Asn Leu Phe Arg Arg Leu Glu Glu Phe Pro Ala Phe Pro65 70
75 80Arg Ala Gln Val Phe Gly Arg Phe
Glu Ala Ser Val Ile Glu Glu Arg 85 90
95Arg Lys Gly Ala Glu Asp Leu Leu Arg Phe Thr Val His Ile
Pro Ala 100 105 110Leu Asn Asn
Ser Pro Gln Leu Lys Glu Phe Phe Arg Gly Gly Glu Val 115
120 125Thr Arg Pro Leu Glu Val Ser Arg Asp Leu His
Ile Leu Pro Pro Pro 130 135 140Leu Ile
Pro Thr Pro Pro Pro Asp Asp Pro Arg Leu Ser Gln Leu Leu145
150 155 160Pro Ala Glu Arg Arg Gly Leu
Glu Glu Leu Glu Val Pro Val Asp Pro 165
170 175Pro Pro Ser Ser Pro Ala Gln Glu Ala Leu Asp Leu
Leu Phe Asn Cys 180 185 190Glu
Ser Thr Glu Glu Ala Ser Gly Ser Pro Ala Arg Gly Pro Leu Thr 195
200 205Glu Ala Glu Leu Ala Leu Phe Asp Pro
Phe Ser Lys Gly Asp Pro Leu 210 215
220Pro Ala Arg Gln Glu Gly Val Lys Lys Lys Ala Ala Glu Tyr Leu Lys225
230 235 240Arg Ala Glu Glu
Ile Leu Arg Leu His Leu Ser Gln Leu Pro Pro 245
250 255
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