Patent application number | Description | Published |
20110172771 | HYDROGEL IMPLANT WITH SUPERFICIAL PORES - Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis. | 07-14-2011 |
20120142597 | BIOMOLECULAR COATING FOR IMPLANTS - Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an α | 06-07-2012 |
20120185051 | ARTICULAR JOINT IMPLANT - Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis. | 07-19-2012 |
20130045360 | SURFACE MODIFICATION OF IMPLANT DEVICES - Provided according to embodiments of the invention are methods of manufacturing implant devices. In methods described herein, implant devices are exposed to a reactive gas that includes a reactive species, and optionally, an inert gas, at elevated temperatures, for a duration sufficient to generate a high density of nanoscale structures on the exposed surface of the device. Also provided are implant devices formed by methods described herein. | 02-21-2013 |
20130064861 | COMPOSITIONS AND METHODS FOR MODIFYING IN VIVO CALCIFICATION OF HYDROGELS - Provided herein according to some embodiments of the invention are methods of inhibiting or preventing calcification of hydrogels. Such methods may include combining the hydrogel with a buffer solution having a pH lower than 7.4; forming a hydrogel by crosslinking alginate in a solution comprising a bisphosphonate compound; and/or forming a hydrogel by crosslinking a polyanionic polymer with a polyvalent cation that is not Ca | 03-14-2013 |
20130195324 | CRANIAL SUTURE SNAKE ALGORITHM - The invention is directed toward methods for assisting in interpreting medical images, especially useful for segmenting images produced by computed tomography or micro-computed tomography. In one embodiment, the invention is directed to method comprising initially identifying the images of the bones from a medical image, estimating a preliminary boundary of the bones, and subsequently segmenting the bones using a snake algorithm initialized by the preliminary boundary of the bones. The results can then be used to establish morphometric measurements from the medical images based on the segmented bone boundaries. In one embodiment of the present invention, the snake algorithm used is a continuous parametric Fourier series representation to fit and optimize the preliminary boundary of the bones to a more accurate representation of the segmented bone boundary from the data included in the image. | 08-01-2013 |
20140171367 | Polymer Hydrogels For In Vivo Applications And Methods For Using And Preparing Same - Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated. | 06-19-2014 |
20140370111 | PROTEIN DELIVERY FROM STEM CELL MICROCARRIERS - Disclosed are methods and compositions of microbead carriers for delivery of cells and other biologically active substances to diseased or damaged tissue in a subject in need thereof. | 12-18-2014 |