| Patent application number | Description | Published |
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| 20150189302 | COLOR INDEX CODING FOR PALETTE-BASED VIDEO CODING - In palette-based coding, a video coder may form a so-called “palette” as a table of colors representing the video data of a given block. The video coder may code index values for one or more pixels values of a current block of video data, where the index values indicate entries in the palette that represent the pixel values of the current block. A method includes determining a number of entries in a palette, and determining whether a block of video data includes any escape pixels not associated with any entry in the palette. The method includes responsive to determining that the number of entries is one, and that the block does not include any escape pixels, bypassing decoding index values for the pixel values of the block, and determining the pixel values of the block to be equal to the one entry in the palette. | 07-02-2015 |
| 20150189319 | COLOR INDEX CODING FOR PALETTE-BASED VIDEO CODING - In palette-based coding, a video coder may form a so-called “palette” as a table of colors representing the video data of a given block. The video coder may code index values for one or more pixels values of a current block of video data, where the index values indicate entries in the palette that represent the pixel values of the current block. A method includes determining a palette for a block of video data, identifying escape pixel(s) not associated with any palette entries, identifying a single quantization parameter (QP) value for all escape pixels of the block for a given color channel using a QP value for non-palette based coding of transform coefficients, dequantizing each escape pixel using the identified QP value, and determining pixel values of the block using the dequantized escape pixels and index values for any pixel(s) associated with any palette entries. | 07-02-2015 |
| 20150264348 | DICTIONARY CODING OF VIDEO CONTENT - According to aspects of this disclosure, a device for decoding video data includes a memory configured to store the video data and a video decoder comprising one or more processor configured to determine that a current block of the video data is to be decoded using a 1D dictionary mode; receive, for a current pixel of the current block, a first syntax element indicating a starting location of reference pixels and a second syntax element identifying a number of reference pixels; based on the first syntax element and the second syntax element, locate a plurality of luma samples corresponding to the reference pixels; based on the first syntax element and the second syntax element, locate a plurality of chroma samples corresponding to the reference pixels; and copy the plurality of luma samples and the plurality of chroma samples to decode the current block. | 09-17-2015 |
| 20150264363 | PALETTE-BASED VIDEO CODING - In an example, a method of coding video data includes determining, by a video coder and for a block of video data, a palette having a plurality of entries indicating a plurality of respective color values, wherein a first line of the block of video data includes a pixel located adjacent to an edge of the block of video data, and wherein a second line of the block of video data includes a pixel located adjacent to the edge of the block and adjacent to the pixel of the first line. In this example, the method also includes coding, in a scan order, index values that map pixels of the block to entries in the palette, wherein the pixel of the second line immediately follows the pixel of the first line in the scan order. | 09-17-2015 |
| 20150264376 | QUANTIZATION PROCESSES FOR RESIDUE DIFFERENTIAL PULSE CODE MODULATION - In an example, system and method for coding encoded video data. A quantized residue differences block associated with a current block of a picture is generated and a reconstructed prediction residue for each quantized residue difference in the block of quantized residue differences is generated. Each reconstructed prediction residue is added to its corresponding original prediction value to produce a current block of a picture. Generating the reconstructed prediction residue includes performing inverse quantization on blocks of quantized residue differences, wherein the inverse quantization reconstructs data to which uniform quantization residue differential pulse code modulation (RDPCM) has been applied and wherein the quantization is of the form: | 09-17-2015 |
| 20150281703 | DETERMINING PALETTE SIZE, PALETTE ENTRIES AND FILTERING OF PALETTE CODED BLOCKS IN VIDEO CODING - Techniques are described for palette-based coding. In palette-based coding, a video coder may form a palette as a table of colors for representing video data of a given block. Palette-based coding may be useful for coding blocks of video data having a relatively small number of colors. Rather than coding actual pixel values or their residuals for the given block, the video coder may code index values for one or more of the pixels. The index values map the pixels to entries in the palette representing the colors of the pixels. Techniques are described for determining whether to disable filtering, such as deblocking filtering or sample adaptive offset (SAO) filtering, of palette coded blocks at a video encoder or a video decoder. Techniques are also described for modify a palette size and palette entries of a palette at the video encoder based on rate-distortion costs. | 10-01-2015 |
| 20150281728 | PALETTE PREDICTOR SIGNALING WITH RUN LENGTH CODE FOR VIDEO CODING - Techniques for encoding a binary prediction vector for predicting a palette for palette-based video coding is described. In one example, a method of decoding video comprises receiving an encoded binary prediction vector for a current block of video data, decoding the encoded binary prediction vector using a run-length decoding technique, generating a palette for the current block of video data based on the binary prediction vector, the binary prediction vector comprising entries indicating whether or not previously-used palette entries are reused for the palette for the current block of video data, and decoding the current block of video data using the palette. | 10-01-2015 |
| 20150373325 | SINGLE COLOR PALETTE MODE IN VIDEO CODING - Techniques are described for palette-based video coding. In palette-based coding, a video coder may form a “palette” as a table of colors for representing video data of a particular area (e.g., a given block). Rather than coding actual pixel values (or their residuals), the video coder may code palette index values for one or more of the pixels that correspond to entries in the palette representing the colors of the pixels. A palette may be explicitly encoded, predicted from previous palette entries, or a combination thereof. In this disclosure, techniques are described for coding a block of video data that has a single color value using a single color mode as a sub-mode of a palette coding mode. The disclosed techniques enable a block having a single color value to be coded with a reduced number of bits compared to a normal mode of the palette coding mode. | 12-24-2015 |
| 20150373339 | COPY FROM PREVIOUS ROWS FOR PALETTE MODE CODING - An example method of decoding video data includes determining a palette for decoding a block of video data, where the palette includes one or more palette entries each having a respective palette index, determining a first plurality of palette indices for first pixels of the block of video data, enabling a palette coding mode based on a run length of a run of a second plurality of palette indices for second pixels of the block of video data being decoded relative to the first plurality of palette indices meeting a run length threshold, and decoding the run of the second plurality of palette indices relative to the first plurality of palette indices using the palette coding mode. | 12-24-2015 |
| 20150373340 | COPY FROM PREVIOUS ROWS FOR PALETTE MODE CODING - An example method of decoding video data includes determining a palette for decoding a block, the palette including entries each having a respective palette index, determining a reference run of palette indices for first pixels of the block, and determining a current run of palette indices for second pixels of the block, based on the reference run. Determining the second plurality of palette indices includes locating a reference index of the reference run, the reference index being spaced at least one line from an initial index of the current run, determining a run length of the reference run, a final index of the reference run being separated from the initial index of the current run by at least one index, copying the palette indices of the reference run as the current run of palette indices, and decoding pixels of the copied current run using the palette. | 12-24-2015 |
| 20160007042 | METHOD FOR PALETTE MODE CODING - A method for decoding video data provided in a bitstream, where the bitstream includes a coding unit (CU) coded in palette mode, includes: parsing a palette associated with the CU provided in the bitstream; parsing one or more run lengths provided in the bitstream that are associated with the CU; parsing one or more index values provided in the bitstream that associated with the CU; and parsing one or more escape pixel values provided in the bitstream that are associated with the CU. The escape pixel values may be parsed from consecutive positions in the bitstream, the consecutive positions being in the bitstream after all of the run lengths and the index values associated with the CU. The method may further include decoding the CU based on the parsed palette, parsed run lengths, parsed index values, and parsed escape values. | 01-07-2016 |
| 20160029028 | SUB-BLOCK PALETTE MODE - Video data may comprise one or more blocks, each block being associated with a block palette comprising one or more palette entries specifying pixel values used in the block. A block is further divided into a plurality of sub-blocks. A sub-block scanning order for the block and pixel scanning orders for the sub-blocks are adaptively selected, based upon a distribution of pixel values within the block and sub-blocks. Sub-blocks may be associated with sub-block palettes, specifying pointers to palette entries of the block palette. Some sub-blocks may be encoded based upon pixel values of neighboring sub-blocks. | 01-28-2016 |
| 20160057447 | METHODS INCORPORATING EXTENSIONS TO COPY-ABOVE MODE FOR PALETTE MODE CODING - Methods incorporating extensions to copy-above mode for palette mode coding are disclosed. In one aspect, the method includes coding a current pixel of a current block of video data in copy-previous mode via coding a previous line index. The coding of the current pixel in copy-previous mode further including identifying a number of candidate values for the previous line index, identifying a number of escape pixels in a column of pixels above the current pixel in the current block, and reducing a number of candidate values of the previous line index by the number of identified escape pixels. | 02-25-2016 |
| 20160094852 | EXPLICIT SIGNALING OF ESCAPE SAMPLE POSITIONS IN PALETTE CODING MODE FOR VIDEO CODING - A method of decoding video data, the method comprising receiving a run-length sequence indicative of a binary vector, the binary vector comprising indications of locations of escape samples in a block of video data encoded using a palette-based coding mode, decoding the run-length sequence to obtain the binary vector, and decoding the block of video data using the binary vector. The method of claim | 03-31-2016 |
| 20160100171 | PALETTE INDEX BINARIZATION FOR PALETTE-BASED VIDEO CODING - An example method of coding video data includes determining, for a current block of video data, a palette that includes a plurality of entries that each corresponds to a respective color value; determining a particular entry in the palette that is predicted to correspond to a color value of a current pixel of the current block; selecting a binarization from a plurality of binarizations; and coding, using the selected binarization, an index that indicates which entry in the palette corresponds to a color value for a current pixel of the current block, wherein coding the index using a first binarization of the plurality of binarizations comprises coding a syntax element that indicates whether the index is equal to the particular entry, and wherein coding the index using a second binarization of the plurality of binarizations comprises coding the index using a variable length code without coding the syntax element. | 04-07-2016 |
| 20160100176 | DIAGONAL COPY FOR PALETTE MODE CODING - Techniques are described where a current pixel that cannot be palette mode coded in copy above mode and is not coded in a copy index mode is palette mode coded based on a palette index of a diagonal pixel. | 04-07-2016 |
| 20160100177 | NON-UNIFORM EXPONENTIAL-GOLOMB CODES FOR PALETTE MODE CODING - In an example, a method of decoding video data using palette mode may include receiving a palette mode encoded block of video data of a picture. The method may include receiving encoded palette mode information for the palette mode encoded block of video data. The encoded palette mode information may be encoded according to a kth order non-uniform truncated exponential-Golomb (TEGk) coding scheme and includes a unary prefix code word and a suffix code word. The method may include entropy decoding the encoded palette mode information using the kth order non-uniform truncated exponential-Golomb (TEGk) coding scheme. The kth order non-uniform TEGk coding scheme is different from a kth order exponential-Golomb (EGk) coding scheme and a kth order truncated exponential-Golomb (TEGk) coding scheme. The method may include decoding the palette mode encoded block of video data using the decoded palette mode information. | 04-07-2016 |
| 20160105676 | PALETTE RUN HIDING IN PALETTE-BASED VIDEO CODING - A video decoder may obtain a syntax element from a bitstream comprising an encoded representation of a block of video data. The block comprises a series of runs, each of which may consist of one pixel or two or more consecutive pixels. Furthermore, the video decoder may obtain a set of palette run length syntax elements indicating lengths of one or more of the runs. The video decoder may determine, based on the syntax element, that the palette run length syntax elements do not include a palette run length syntax element indicating a length of the first run. Rather, the video decoder determines, based on the lengths indicated by the set of palette run syntax elements, the length of the first run. The video decoder may determine, based on the palette sample modes of the pixels, palette indices of the pixels, each indicating an entry in a palette. | 04-14-2016 |
| 20160105685 | BOUNDARY FILTERING AND CROSS-COMPONENT PREDICTION IN VIDEO CODING - Techniques for coding video data include determining that a block of a first component of the video data is intra-predicted using one of a DC mode, a horizontal mode, or a vertical mode, determining that a corresponding block of a second component of the video data is intra-predicted using the same mode as the block of the first component according to a direct mode to form a predicted block for the second component, and boundary filtering the predicted block in response to the determinations. In some examples, the first component is a luma component, and the second component is a chroma component. | 04-14-2016 |
| Patent application number | Description | Published |
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| 20100066917 | Multi-Tuner Variable Low IF Receiver for Multi-Channel Applications - Systems and methods for demodulating a plurality of contiguous channels contained within a bandlimited portion of a radio-frequency (RF) input signal are provided. In an embodiment, the bandlimited portion of the RF input signal is down-converted to baseband. After down-conversion, the bandlimited portion overlaps at baseband with a mirror image of the bandlimited portion. The plurality of contiguous channels within the down-converted signal similarly overlap at baseband and subsequently occupy a bandwidth substantially equal to half that required before down-converting. Image rejection is performed in the digital domain to recover each of the plurality of overlapping channels. | 03-18-2010 |
| 20100067630 | Variable Low IF Receiver for Multi-Channel Applications - Systems and methods for demodulating a plurality of contiguous channels contained within a bandlimited portion of a radio-frequency (RF) input signal are provided. In an embodiment, the bandlimited portion of the RF input signal is down-converted to baseband. After down-conversion, the bandlimited portion overlaps at baseband with a mirror image of the bandlimited portion. The plurality of contiguous channels within the down-converted signal similarly overlap at baseband and subsequently occupy a bandwidth substantially equal to half that required before down-converting. Image rejection is performed in the digital domain to recover each of the plurality of overlapping channels. | 03-18-2010 |
| 20110200091 | Asymmetric Multi-Channel Adaptive Equalizer - An apparatus is disclosed to compensate for non-linear effects resulting from the transmitter, the receiver, and/or the communication channel in a communication system. A receiver of the communication system contains an image cancellation module that compensates for images generated during the modulation and/or demodulation process. The image cancellation module includes a fine carrier correction loop to correct for frequency offsets between the transmitter and receiver. The image cancellation module includes a coarse acquisition mode and a decision directed mode. The decision directed mode allows for a larger signal-to-noise ratio for the receiver when compared against the coarse acquisition mode. | 08-18-2011 |
| 20120082272 | SELECTABLE INTERFERENCE CANCELLATION IN A COMMUNICATIONS RECEIVER - Method and apparatuses are disclosed to substantially compensate for various unwanted interferences and/or distortions within a communications receiver. Each of these apparatuses and methods estimate the various unwanted interferences and/or distortions within the communications receiver. Each of these apparatuses and methods remove the estimates of the various unwanted interferences and/or distortions within the communications receiver from one or more communications signals within the communications receiver to substantially compensate for the various unwanted interferences and/or distortions. | 04-05-2012 |
| 20120082276 | COMPENSATING FOR UNWANTED INTERFERENCE IN A COMMUNICATIONS RECEIVER - Method and apparatuses are disclosed to substantially compensate for various unwanted interferences and/or distortions within a communications receiver. Each of these apparatuses and methods estimate the various unwanted interferences and/or distortions within the communications receiver. Each of these apparatuses and methods remove the estimates of the various unwanted interferences and/or distortions within the communications receiver from one or more communications signals within the communications receiver to substantially compensate for the various unwanted interferences and/or distortions. | 04-05-2012 |
| 20120082277 | CONFIGURABLE ADAPTIVE FILTER - Method and apparatuses are disclosed to substantially compensate for various unwanted interferences and/or distortions within a communications receiver. Each of these apparatuses and methods estimate the various unwanted interferences and/or distortions within the communications receiver. Each of these apparatuses and methods remove the estimates of the various unwanted interferences and/or distortions within the communications receiver from one or more communications signals within the communications receiver to substantially compensate for the various unwanted interferences and/or distortions. | 04-05-2012 |
| 20120082278 | COMPENSATING FOR UNWANTED INTERFERENCE IN A COMMUNICATIONS RECEIVER - Method and apparatuses are disclosed to substantially compensate for various unwanted interferences and/or distortions within a communications receiver. Each of these apparatuses and methods estimate the various unwanted interferences and/or distortions within the communications receiver. Each of these apparatuses and methods remove the estimates of the various unwanted interferences and/or distortions within the communications receiver from one or more communications signals within the communications receiver to substantially compensate for the various unwanted interferences and/or distortions. | 04-05-2012 |
| 20120083235 | COMPENSATING FOR UNWANTED DISTORTION IN A COMMUNICATIONS RECEIVER - Method and apparatuses are disclosed to substantially compensate for various unwanted interferences and/or distortions within a communications receiver. Each of these apparatuses and methods estimate the various unwanted interferences and/or distortions within the communications receiver. Each of these apparatuses and methods remove the estimates of the various unwanted interferences and/or distortions within the communications receiver from one or more communications signals within the communications receiver to substantially compensate for the various unwanted interferences and/or distortions. | 04-05-2012 |
| 20120189046 | Asymmetric Multi-Channel Adaptive Equalizer - An apparatus is disclosed to compensate for non-linear effects resulting from the transmitter, the receiver, and/or the communication channel in a communication system. A receiver of the communication system contains an image cancellation module that compensates for images generated during the modulation and/or demodulation process. The image cancellation module includes a fine carrier correction loop to correct for frequency offsets between the transmitter and receiver. The image cancellation module includes a coarse acquisition mode and a decision directed mode. The decision directed mode allows for a larger signal-to-noise ratio for the receiver when compared against the coarse acquisition mode. | 07-26-2012 |
| 20120196551 | COMMUNICATION RECEIVER ENHANCEMENTS USING MULTI-SIGNAL CAPTURE - A method and apparatus is disclosed to determine communications receiver parameters from multiple channels of a received communications signal and to configure and/or adjust communications receiver parameters to acquire one or more channels from among the multiple channels of the received communications signal. A communications receiver observes a multi-channel communication signal as it passes through a communication channel. The communications receiver determines one or more communications receiver parameters from the multiple channels of the received communications signal. The communications receiver configures and/or adjusts communications receiver parameters to acquire the one or more channels from among the multiple channels of the received communications signal. | 08-02-2012 |
| 20140294052 | COMMUNICATION SYSTEM WITH PROACTIVE NETWORK MAINTENANCE AND METHODS FOR USE THEREWITH - A transmitter for use in a cable modem termination system includes a data processing module that generates a plurality of OFDM symbols from a data packet. A probe symbol generator generates a probe symbol, as one of a plurality of probe symbol types. The probe symbol is selectively inserted within the plurality of OFDM symbols, at a pre-defined probe symbol interval. | 10-02-2014 |
| 20150263772 | Communication Receiver Enhancements Using Multi-Signal Capture - A method and apparatus is disclosed to determine communications receiver parameters from multiple channels of a received communications signal and to configure and/or adjust communications receiver parameters to acquire one or more channels from among the multiple channels of the received communications signal. A communications receiver observes a multi-channel communication signal as it passes through a communication channel. The communications receiver determines one or more communications receiver parameters from the multiple channels of the received communications signal. The communications receiver configures and/or adjusts communications receiver parameters to acquire the one or more channels from among the multiple channels of the received communications signal. | 09-17-2015 |
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| 20090197935 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT | 08-06-2009 |
| 20110053958 | MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - The present invention relates to amide derivatives of Formula (XIIIa) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disease, a congenital heart disease, portal hypertension, HIV infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH); PAH with significant venous or capillary involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD). | 03-03-2011 |
| 20110224262 | PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD). | 09-15-2011 |
| 20110245251 | MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD). | 10-06-2011 |
| 20120270861 | Primary Amines And Derivatives Thereof As Modulators Of The 5-HT2A Serotonin Receptor Useful For The Treatment Of Disorders Related Thereto - The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT | 10-25-2012 |
| 20130217706 | MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - The present invention relates to amide derivatives of Formula (XIIIa) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disease; and other diseases. | 08-22-2013 |
| 20140171469 | PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD). | 06-19-2014 |
| 20140235622 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT | 08-21-2014 |
| 20140309192 | MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO - The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts, solvates, and hydrates thereof: | 10-16-2014 |
| 20150126527 | MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - The present invention relates to amide derivatives of Formula (XIIIa) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: Pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disease, a congenital heart disease, portal hypertension, HIV infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH); PAH with significant venous or capillary involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack, angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD). | 05-07-2015 |
| 20150152187 | Anti-PSMA Antibodies Conjugated to Nuclear Receptor Ligand Polypeptides - This invention relates to anti-prostate-specific membrane antigen antibodies (αPSMA) and αPSMA antibody—nuclear receptor ligand (NRL) conjugates comprising at least one non-naturally-encoded amino acid. | 06-04-2015 |
| 20150191454 | MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD). | 07-09-2015 |
| 20150191455 | PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD). | 07-09-2015 |
| 20150265576 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT | 09-24-2015 |
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| 20090072197 | FLUORESCENT POLYMERIC MATERIALS CONTAINING LIPID SOLUBLE RHODAMINE DYES - Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using said materials are also disclosed. | 03-19-2009 |
| 20090093062 | Fluorescent Dye Compounds, Conjugates and Uses Thereof - The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof. | 04-09-2009 |
| 20090172899 | PHENYL XANTHENE DYES - Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes. The phenyl xanthene dyes are useful for a number of purposes, including labels for use in automated DNA sequencing as well the formation of fluorescent “bar codes” for polymeric particles used in the multiplexed analysis of analytes. | 07-09-2009 |
| 20110226994 | Fluorescent Polymeric Materials Containing Lipid Soluble Rhodamine Dyes - Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using said materials are also disclosed. | 09-22-2011 |
| 20110250699 | Fluorescent Dye Compounds, Conjugates and Uses Thereof - The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof. | 10-13-2011 |
| 20130171715 | Phenyl Xanthene Dyes - Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes. The phenyl xanthene dyes are useful for a number of purposes, including labels for use in automated DNA sequencing as well the formation of fluorescent “bar codes” for polymeric particles used in the multiplexed analysis of analytes. | 07-04-2013 |
| 20140145115 | Fluorescent Polymeric Materials Containing Lipid Soluble Rhodamine Dyes - Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using said materials are also disclosed. | 05-29-2014 |
| 20140242665 | Phenyl Xanthene Dyes - Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes. The phenyl xanthene dyes are useful for a number of purposes, including labels for use in automated DNA sequencing as well the formation of fluorescent “bar codes” for polymeric particles used in the multiplexed analysis of analytes. | 08-28-2014 |
| 20140303003 | Fluorescent Dye Compounds, Conjugates and Uses Thereof - The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof. | 10-09-2014 |
| 20150274975 | Phenyl Xanthene Dyes - Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes. The phenyl xanthene dyes are useful for a number of purposes, including labels for use in automated DNA sequencing as well the formation of fluorescent “bar codes” for polymeric particles used in the multiplexed analysis of analytes. | 10-01-2015 |
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| 20120092988 | METHOD, APPARATUS, AND SYSTEM FOR JUDGING PATH CONGESTION - The present disclosure relates to the field of communications, and discloses a method for determining path pre-congestion. The method is applicable to an Ethernet path. Pre-congestion is determined and flagged through an ingress node or an intermediate node in the Ethernet path, and a pre-congestion status indication packet is sent by an egress node to the ingress node or a policy server, so that the ingress node or the policy server obtains pre-congestion information of the Ethernet path, and notify an application function entity AF of performing admission control. When the method in the present disclosure is used, problems of packet loss and excessively long time delay caused by the conventional congestion control technology may be avoided, thereby ensuring user experience of existing services. | 04-19-2012 |
| 20120176994 | METHOD, DEVICE AND SYSTEM FOR OFFLOADING NETWORK TRAFFIC - A method, a device, and a system for offloading network traffic are provided, which are applied in the field of mobile communications. An offloading device located before a Serving General Packet Radio Service Support Node (SGSN) receives a data stream of a user sent by a base station, obtains an offloading policy of the user from the offloading device and/or obtains the offloading policy of the user from a policy server, and forwards the data stream according to the offloading policy. Accordingly, the offloading device can obtain the corresponding offloading policy according to the data stream sent by a forwarding plane, send a data stream of low value, low real-time performance requirement, or low priority to the Internet or another specific networks, and send a data stream of high value, high real-time performance requirement, or high priority to high-value devices, thereby reducing the networking cost. | 07-12-2012 |
| 20130070770 | METHOD, DEVICE, AND SYSTEM FOR FORWARDING PACKET - The embodiments of the present invention provide a method, a device, and a system for forwarding a packet. The method includes: receiving an IPv6 packet sent by a gateway, and obtaining a flow label of the IPv6 packet, where the flow label of the IPv6 packet is corresponding to a link identity of customer premise equipment in one-to-one correspondence; decapsulating the IPv6 packet; performing network address translation on a decapsulated packet according to the flow label; and forwarding the decapsulated packet according to a translated network address. When multiple links between the gateway and an AFTR are corresponding to the same tunnel for network address translation, in the case that IP addresses of terminal users are overlapping or are the same, different terminal users can be distinguished, so that a terminal user that sends a packet can receive feedback, thus improving customer satisfaction. | 03-21-2013 |
| 20130301650 | Stateless NAT44 - An apparatus comprising a memory, and a processor coupled to the memory and configured to receive a mapping rule that associates a downstream internal Internet Protocol version four (IPv4) address prefix to an upstream external IPv4 address prefix, receive a first IPv4 packet from an upstream network node with a destination address field comprising an external IPv4 address comprising the external prefix, and perform a first network address translation IPv4 to IPv4 (NAT44) process by replacing the external IPv4 address in the first IPv4 packet's destination address field with an internal IPv4 address based on the mapping rule, wherein the internal IPv4 address comprises the internal prefix and a port set identifier (ID) associated with set of destination ports at a downstream node assigned to receive the first IPv4 packet. | 11-14-2013 |
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| 20130215891 | IGMP/MLD Translation - Disclosed is an apparatus comprising a network element (NE) configured to receive an Internet Group Management Protocol (IGMP) data packet in Internet Protocol version four (IPv4) format, translate the data packet into an Multicast Listener Discovery (MLD) data packet in Internet Protocol version six (IPv6) format, and forward the translated data packet. Also disclosed is an apparatus comprising a NE configured to receive an MLD data packet in IPv6 format, and translate the data packet into an IGMP data packet in IPv4 format. Also disclosed is a method comprising receiving a plurality of data packets, wherein the plurality of data packets comprise IGMP data packets and MLD data packets, translating at least one of the IGMP data packets into a MLD data packet, and translating at least one of the MLD data packets into an IGMP data packet. | 08-22-2013 |
| 20130229922 | DS-Lite with BFD Support - A network node for detecting failures in a Dual Stack Lite (DS-Lite) tunnel, comprising a processor configured to obtain a domain name that identifies a first node, create the DS-Lite tunnel to the first node using the domain name, initiate a first bidirectional forwarding detection (BFD) session to the first node, transmit a plurality of BFD data packets within the DS-Lite tunnel, and detect a failure within the DS-Lite tunnel using the BFD data packets. | 09-05-2013 |
| 20130232278 | IPv4 Data Center Support for IPv4 and IPv6 Visitors - A network element (NE) comprising a processor configured to transmit a message to a domain names system (DNS) server, wherein the message comprises a virtual service internet protocol (VSIP) version six (VSIPv6) address corresponding to a service associated with an internet protocol version four (IPv4) address. Also disclosed is a method comprising associating a remote host internet protocol (IP) version six (IPv6) address with a private IPv4 address in a stateful binding table, and associating a local service IPv4 address with a local service VSIPv6 address in a stateless binding table. | 09-05-2013 |
| 20130250770 | Supporting Software Defined Networking with Application Layer Traffic Optimization - A network node for managing the control plane functions for a plurality of nodes within a software defined networking (SDN) domain, comprising a processor configured to collect a plurality of network information from the nodes, forward the network information based on a plurality of domain-specific policies, receive traffic optimization information based on the network information, and compute forwarding decisions for the nodes based on the traffic optimization information. In another embodiment, an Application Layer Traffic Optimization (ALTO) node, comprising a processor configured to import a first set of network information from one or more SDN nodes, aggregate the network information received from the SDN nodes, calculate a plurality of traffic optimization decisions based on the aggregated network information, and forward the traffic optimization decisions to the SDN nodes. | 09-26-2013 |
| 20130329601 | Defining Data Flow Paths in Software-Defined Networks with Application-Layer Traffic Optimization - A method implemented by a software defined network (SDN) controller, the method comprising receiving, from a network node, a request for path optimization, wherein the request comprises information identifying the network node and a destination node, forwarding the request to an application layer traffic optimization (ALTO) server, receiving, from the ALTO server, path information that identifies a plurality of SDN domains to be traversed from the network node to the destination node, wherein the plurality of SDN domains comprises a first SDN domain, in which the SDN controller resides, and a second SDN domain, in which an edge node known by the SDN controller resides, and determining a first path segment from the network node to the edge node. | 12-12-2013 |
| 20130332619 | Method of Seamless Integration and Independent Evolution of Information-Centric Networking via Software Defined Networking - A method of transferring data between a software defined network (SDN) and an information-centric network (ICN), wherein the method comprises receiving a request from an SDN node for a specific named content stored on an ICN, wherein the request is encapsulated in an Internet Protocol (IP) packet, decapsulating the IP packet using an IP protocol stack, parsing the request to obtain the name of the specific named content, finding a path to an ICN networking device hosting the specific named content using the name, and forwarding the packet to the ICN networking device over the path. | 12-12-2013 |
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| 20080219185 | Method and System For Radio Frequency Management In A Mesh Network With A Path Distance Factor - A method and system for radio frequency management (RFM) in a mesh network using a path distance factor (PDF) is disclosed. According to one embodiment, a computer-implemented method, comprises calculating a path distance factor (PDF) between a first mesh router and a portal. A frame is transmitted to a second mesh router, wherein the frame includes the path distance factor. | 09-11-2008 |
| 20090129273 | Method & apparatus for detecting and avoiding interference in a communications network - A wireless mesh communication network includes a plurality of wireless routers which can be managed in a hierarchical manner with respect to one another and all of the routers are capable of detecting and avoiding interference on channels over which they communicate with one another. Depending upon whether a channel is active or inactive, a wireless router can either passively detect interference and then switch channels to avoid it or actively detect interference and then switch channels to avoid it. | 05-21-2009 |
| 20110216667 | Method and System for a Radio Frequency Management in a Mesh Network with a Path Distance Factor - A method and system for radio frequency management (RFM) in a mesh network using a path distance factor (PDF) is disclosed. According to one embodiment, a computer-implemented method, comprises calculating a path distance factor (PDF) between a first mesh router and a portal. A frame is transmitted to a second mesh router, wherein the frame includes the path distance factor. | 09-08-2011 |
| 20110222435 | Method and System for a Radio Frequency Management in a Mesh Network with a Path Distance Factor - A method and system for radio frequency management (RFM) in a mesh network using a path distance factor (PDF) is disclosed. According to one embodiment, a computer-implemented method, comprises calculating a path distance factor (PDF) between a first mesh router and a portal. A frame is transmitted to a second mesh router, wherein the frame includes the path distance factor. | 09-15-2011 |
| 20130100872 | Method and System for Preventing Loops in Mesh Networks - The present disclosure discloses a network device and/or method for preventing loops in routing paths of network frames in a wireless digital network. The disclosed network device at a network node receives a frame from a wired network. The frame includes a site identifier uniquely corresponding to the wired network, a source physical address, and a destination physical address. If the network node is selected as a representative portal node, the network device forwards the frame. Otherwise, if another network node is selected as the representative portal node, the network device drops the received frame to prevent forming a loop in a routing path corresponding to the frame. If not other network is selected as the representative portal node, the network device floods the frame to other network nodes in the wireless network. | 04-25-2013 |
| 20140282902 | SPLIT AUTHENTICATION NETWORK SYSTEMS AND METHODS - Disclosed is a system comprising: an authentication datastore; a device presence engine; a traffic monitor engine; an authentication presence monitor engine; an authentication server selection engine; and a traffic routing engine. In operation: the device presence engine is configured to detect presence of a user device on a trusted network; the traffic monitor engine is configured to monitor, in response to the detection, traffic on the trusted network from the device; the authentication presence monitor engine is configured to evaluate onboarding characteristics of the user device in response to the monitoring; the authentication server selection engine is configured to select one of a plurality of authentication servers to authenticate the user device to the trusted network, the selecting based on the onboarding characteristics; and the traffic routing engine is configured to route traffic from the user device to the selected authentication server. | 09-18-2014 |
| 20140282972 | WIRELESS DEVICE AUTHENTICATION AND SERVICE ACCESS - Authenticating a client device coupled to an authenticator network device for a network. A service request is received from the client device at the authenticator network device. User credentials, including a user ID, a user key, and a nonce for a user are received at the authenticator network device. A token is generated using the received user credentials. The service request is modified to include the token and a user ID parameter that is the user ID to generate a modified service request. The modified service request is used to provide single sign-on access to a service that is the subject of the service request. | 09-18-2014 |
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| 20110081365 | COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X | 04-07-2011 |
| 20120177681 | Formulation of immunopotentiators - Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form. | 07-12-2012 |
| 20130065861 | COMPOUNDS (CYSTEIN BASED LIPOPEPTIDES) AND COMPOSITIONS AS TLR2 AGONISTS USED FOR TREATING INFECTIONS, INFLAMMATIONS, RESPIRATORY DISEASES ETC. - The invention provides a novel class of compounds viz. generally lipopeptides like Pam3CSK4, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 2. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness a vaccine. | 03-14-2013 |
| 20130253002 | COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X | 09-26-2013 |
| 20130274465 | ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS - Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form. | 10-17-2013 |
| 20140323390 | COMPOUNDS AND COMPOSITIONS AS TLR2 AGONISTS - The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 2. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine. | 10-30-2014 |
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| 20130219347 | METHODS FOR DECOMPOSING CIRCUIT DESIGN LAYOUTS AND FOR FABRICATING SEMICONDUCTOR DEVICES USING DECOMPOSED PATTERNS - Methods for fabricating semiconductor devices are provided. In an embodiment, a method of fabricating a semiconductor device includes scanning a circuit design layout and proposing patterns for decomposed layouts. The proposed patterns are then compared with a library of prior patterns including a category of forbidden patterns and a category of preferred patterns. If a selected proposed pattern matches a forbidden pattern, the selected proposed pattern is eliminated. If the selected proposed pattern matches a preferred pattern, then the selected proposed pattern is identified for use in the decomposed layouts. Decomposed layouts are generated from the identified patterns. A plurality of masks is fabricated based on the decomposed layouts. Then a multiple patterning lithographic technique is performed with the plurality of masks on a semiconductor substrate. | 08-22-2013 |
| 20140282296 | HYBRID METHOD FOR PERFORMING FULL FIELD OPTICAL PROXIMITY CORRECTION FOR FINFET MANDREL LAYER - A hybrid OPC process and a resulting reticle are disclosed. Embodiments include generating a finfet fin reticle including a first portion having regular pitches and a second portion having irregular pitches, performing rule based OPC on at least the first portion, and performing OPC repair locally at the second portion. | 09-18-2014 |
| 20140282299 | METHOD AND APPARATUS FOR PERFORMING OPTICAL PROXIMITY AND PHOTOMASK CORRECTION - An approach is provided for enabling simulation of photomask contour shapes, performing verification on the simulated photomask shapes, and correcting errors in OPC correction or bad fracturing methods to perform photomask proximity correction in real time before physically writing of the photomask. Embodiments include performing optical proximity correction of a photomask of a semiconductor layout to generate a corrected photomask, simulating the corrected photomask to generate one or more simulated contour shapes within a simulated photomask, verifying the simulated contour shapes to determine errors associated with the simulated photomask, and correcting the errors in the simulated contour shapes of the simulated photomask to generate a final photomask. | 09-18-2014 |
| 20150126032 | METHODS FOR FABRICATING INTEGRATED CIRCUITS INCLUDING GENERATING E-BEAM PATTERNS FOR DIRECTED SELF-ASSEMBLY - Methods for fabricating integrated circuits are provided. In one example, a method for fabricating an integrated circuit includes generating an e-beam pattern for forming a DSA directing pattern on a semiconductor substrate. The DSA directing pattern is configured to guide a self-assembly material deposited thereon that undergoes directed self-assembly (DSA) to form a DSA pattern. Generating the e-beam pattern includes using a computing system, inputting a DSA target pattern. Using the computing system, the DSA target pattern, a DSA model, and an EBPC model, an output EBPCed pattern is produced for an e-beam writer to write on a resist layer that overlies the semiconductor substrate. | 05-07-2015 |
| 20150235839 | METHODS FOR FABRICATING INTEGRATED CIRCUITS USING DIRECTED SELF-ASSEMBLY INCLUDING LITHOGRAPHICALLY-PRINTABLE ASSIST FEATURES - Methods for fabricating integrated circuits are provided. In one example, a method for fabricating an integrated circuit includes forming assisting etch resistant fill topographical features that overlie a semiconductor substrate and that define an assisting etch resistant fill confinement well using a photomask. The photomask defines an assisting lithographically-printable mask feature. A block copolymer is deposited into the assisting etch resistant fill confinement well. The block copolymer is phase separated into an etchable phase and an etch resistant phase. The assisting etch resistant fill topographical features direct the etch resistant phase to form an etch resistant plug in the assisting etch resistant fill confinement well. | 08-20-2015 |
| 20150242555 | METHODS FOR FABRICATING INTEGRATED CIRCUITS INCLUDING GENERATING PHOTOMASKS FOR DIRECTED SELF-ASSEMBLY - Methods for fabricating integrated circuits are provided. In one example, a method for fabricating an integrated circuit includes generating a photomask for forming a DSA directing pattern overlying a semiconductor substrate. The DSA directing pattern is configured to guide a self-assembly material deposited thereon that undergoes directed self-assembly (DSA) to form a DSA pattern. Generating the photomask includes inputting DSA target patterns. The DSA target patterns are grouped into groups including a first group and a group boundary is defined around the first group as an initial OPC mask pattern. A circle target is generated around each of the DSA target patterns in the first group to define a merged circle target boundary. The initial OPC mask pattern is adjusted and/or iteratively updated using the merged circle target boundary to generate an output final OPC mask pattern. | 08-27-2015 |
| 20150287176 | METHOD AND APPRATUS FOR HYBRID TEST PATTERN GENERATION FOR OPC MODEL CALIBRATION - A method and apparatus for hybrid test pattern generation for optical proximity correction (OPC) model calibration is disclosed. Embodiments may include receiving a mask pattern of a chip layout, extracting one or more patterns from the mask pattern, determining one or more parametric data sets for the one or more patterns, retrieving one or more calibration parametric data sets based on one or more other mask patterns, determining a difference between the one or more parametric data sets and the one or more calibration parametric data sets, and adding the one or more parametric data sets to the one or more calibration parametric data sets if the difference satisfies a threshold value. | 10-08-2015 |
| 20150339429 | METHODS FOR FABRICATING INTEGRATED CIRCUITS INCLUDING GENERATING PHOTOMASKS FOR DIRECTED SELF-ASSEMBLY (DSA) USING DSA TARGET PATTERNS - Methods for fabricating integrated circuits are provided. In one example, a method for fabricating an integrated circuit includes generating a photomask for forming a DSA directing pattern overlying a semiconductor substrate. The DSA directing pattern is configured to guide a self-assembly material deposited thereon that undergoes directed self-assembly (DSA) to form a DSA pattern. Generating the photomask includes identifying placement of DSA target patterns in a design layout. The DSA target patterns are grouped into groups including a first group and a first group boundary is defined around the first group. The method further includes determining if a neighboring DSA target pattern to the first group boundary is at least a predetermined minimal keep-away distance from an adjacent DSA target pattern that is within the first group boundary. The method also includes determining if the DSA target patterns in the first group are DSA compatible. An output mask pattern is generated using the first group boundary. | 11-26-2015 |
