Zhu, Palo Alto
Fangfang Zhu, Palo Alto, CA US
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20150140665 | Site-Specific Integration of Transgenes into Human Cells - Methods for inserting a polynucleotide sequence into the genome of a human cell are provided. The present methods result in insertion of a polynucleotide sequence of interest into the H11 locus in the genome of a human cell. Also provided are nucleic acids that include sequences for integrating a polynucleotide sequence of interest into the H11 locus in the genome of a human cell. A transgenic human cell including site specific recombination sites at the H11 locus is also disclosed. | 05-21-2015 |
Jay J. Zhu, Palo Alto, CA US
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20130138682 | HIERARCHICAL GRID FOR SPATIAL QUERYING - Techniques are provided for improving performance of spatial queries by defining a grid that divides the domain space into cells, and then using a cell-to-item mapping to determine which items do not have to be individually evaluated against the location criteria of the spatial queries. Based on the cell to which an item belongs, the item may automatically qualify as a match, be automatically disqualified, or require item-specific evaluation. To account for items with size, the query window of a spatial query may be expanded. To limit the degree to which the query window is expanded, a plurality of grids may be established for the domain space, where each grid has differently sized cells, and items are assigned to grids based on the size of the items. | 05-30-2013 |
Jiajun Zhu, Palo Alto, CA US
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20100215250 | SYSTEM AND METHOD OF INDICATING TRANSITION BETWEEN STREET LEVEL IMAGES - A system and method of displaying transitions between street level images is provided. In one aspect, the system and method creates a plurality of polygons that are both textured with images from a 2D street level image and associated with 3D positions, where the 3D positions correspond with the 3D positions of the objects contained in the image. These polygons, in turn, are rendered from different perspectives to convey the appearance of moving among the objects contained in the original image. | 08-26-2010 |
20100295971 | IMAGE ZOOMING USING PRE-EXISTING IMAGING INFORMATION - Aspects of the invention pertain to enhanced zooming capability of user devices. A user device such as a mobile phone with a camera may capture images of different objects of interest. The capture and zooming limitations of the user device are overcome by replacing, supplementing or otherwise enhancing the image taken with one or more geo-coded images stored in a database. For instance, if the user attempts to zoom in on a feature of an object of interest and exceeds the zooming capability of the user device, a request is sent to a remote server to provide an image showing the feature of the object of interest at a desired resolution. The server determines which, if any, stored images correlate to the captured image of the object of interest. The resulting imagery is provided to the user device and is presented on a display. | 11-25-2010 |
20150116326 | USING IMAGE CONTENT TO FACILITATE NAVIGATION IN PANORAMIC IMAGE DATA - The present invention relates to using image content to facilitate navigation in panoramic image data. In an embodiment, a computer-implemented method for navigating in panoramic image data includes: (1) determining an intersection of a ray and a virtual model, wherein the ray extends from a camera viewport of an image and the virtual model comprises a plurality of facade planes; (2) retrieving a panoramic image; (3) orienting the panoramic image to the intersection; and (4) displaying the oriented panoramic image. | 04-30-2015 |
Kai Zhu, Palo Alto, CA US
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20100192117 | ARCHITECTURE AND METHOD FOR COMPENSATING FOR DISPARATE SIGNAL RISE AND FALL TIMES BY USING POLARITY SELECTION TO IMPROVE TIMING AND POWER IN AN INTEGRATED CIRCUIT - A method for reducing delay in an integrated circuit by compensating for differences in rise and fall delay times comprises creating a timing graph; computing minimum delay tuples for nodes in the timing graph; if there is not at least one feasible delay tuple, determining a longest path and computing minimum delay tuples for the longest path; changing polarities on the longest path to reduce delays; updating the timing graph by transferring new polarity and delay values; performing timing analysis to determine a new longest path if the new longest path is shorter than the prior longest path, accepting a resulting polarity selection and computing minimum delay tuples for the longest path; if the new longest path is not shorter than the prior longest path, accepting a resulting polarity selection and implementing changes in a user-program bitstream. | 07-29-2010 |
Li Zhu, Palo Alto, CA US
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20100227774 | Method For Generating and Selecting Antibodies Against Target Protein - Compositions are provided that comprise antibody against membrane proteins such as chemokine receptors. In particular, monoclonal human antibodies against human CXCR4 are provided that are capable of inhibiting HIV infection and chemotaxis in human breast cancer cells. The antibodies can be used as prophylactics or therapeutics to prevent and treat HIV infection and cancer, for screening drugs, and for diagnosing diseases or conditions associated with interactions with chemokine receptors. | 09-09-2010 |
20120322672 | METHOD FOR GENERATING AND SELECTING ANTIBODIES AGAINST TARGET PROTEIN - Compositions are provided that comprise antibody against membrane proteins such as chemokine receptors. In particular, monoclonal human antibodies against human CXCR4 are provided that are capable of inhibiting HIV infection and chemotaxis in human breast cancer cells. The antibodies can be used as prophylactics or therapeutics to prevent and treat HIV infection and cancer, for screening drugs, and for diagnosing diseases or conditions associated with interactions with chemokine receptors. | 12-20-2012 |
Ming Zhu, Palo Alto, CA US
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20150296010 | Asynchronous Download for Application Offline Support - A technique is described providing offline support to business applications. Offline support allows a business application running on a portable electronic device without connectivity to a backend server to operate as though the business application has access to a backend server. The technique receives a sync request for content from the portable electronic device. A sync task is generated from the sync requests and processed to generate a package that contains the desired content. Once the package is generated, the package is stored in a package repository and a download notification is transmitted to the portable electronic device to notify the user that the package is ready. The package can in turn be delivered to the portable electronic device when a download request is received from the portable electronic device. | 10-15-2015 |
Ming Benjamin Zhu, Palo Alto, CA US
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20080256326 | Subsegmenting for efficient storage, resemblance determination, and transmission - Transmitting or storing subsegments is disclosed. A data stream or a data block is received and broken into a plurality of segments. For at least one segment, the segment is broken into a plurality of subsegments. A previously stored or transmitted segment similar to the at least one segment is identified. A fingerprint is computed for at least one subsegment. And, using the fingerprint for the at least one subsegment, determining whether the at least one subsegment is identical to a subsegment of the previously stored or transmitted segment without directly comparing the content of the at leas one subsegment with the content of the subsegment of the previously stored or transmitted segment. | 10-16-2008 |
Qiming Zhu, Palo Alto, CA US
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20100261478 | BASE STATION SUBSYSTEM MULTIPLEXER WITH SUPPORT FOR LOCAL SWITCHING - In one embodiment, a wireless system comprises a host MSC/VLR of a public land mobile network (PLMN) and a plurality of base station subsystems (BSSs). Each BSS includes a respective base station controller (BSC) and one or more base transceiver stations (BTSs). The wireless system further comprises a virtual base station controller (VBSC) communicatively coupled to the plurality of BSSs and the host MSC/VLR. The VBSC appears, from the perspective of the host MSC/VLR, to be a base station controller for the BTSs in the plurality of BSSs. The VBSC and at least some of the BSSs include functionality for locally switching calls in the BSSs. | 10-14-2010 |
20140044116 | BASE STATION SUBSYSTEM MULTIPLEXER WITH SUPPORT FOR LOCAL SWITCHING - In one embodiment, a wireless system comprises a host MSC/VLR of a public land mobile network (PLMN) and a plurality of base station subsystems (BSSs). Each BSS includes a respective base station controller (BSC) and one or more base transceiver stations (BTSs). The wireless system further comprises a virtual base station controller (VBSC) communicatively coupled to the plurality of BSSs and the host MSC/VLR. The VBSC appears, from the perspective of the host MSCNLR, to be a base station controller for the BTSs in the plurality of BSSs. The VBSC and at least some of the BSSs include functionality for locally switching calls in the BSSs. | 02-13-2014 |
20150117349 | OPTIMIZING MOBILE NETWORK BANDWIDTH - A gateway turns encrypted PS data traffic on the Iub interface into clear IP packets so that WAN stream de-duplication and other optimization can be performed to eliminate the transfer of repetitive data across the Iub interface, thereby increasing the throughput between the NodeB and the RNC of the WCDMA network. The gateway pulls PS data traffic out from Iub without disturbing the signaling and CS traffic. The bifurcated PS data traffic is redirected to the GTP I/O port of the gateway where the stream de-duplication is applied. Deployment of the gateway is transparent to the WCDMA network. No network reconfiguration is required to deploy the gateway on the Iub interface. | 04-30-2015 |
Ying Zhu, Palo Alto, CA US
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20150259425 | COMPOSITIONS AND METHODS FOR PRODUCING GLYCOPROTEINS - The present disclosure relates to methods of producing antibodies with increased levels of non-fucosylated glycoforms by culturing mammalian cells in culture media with enhanced concentrations of glycine relative to traditional basal media. | 09-17-2015 |
York Yuanyuan Zhu, Palo Alto, CA US
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20120071542 | Application of Highly Conserved Domain Sequences From Viral Genome As Template To Design Therapeutic Slirnas - This invention relates to the application of the highly conserved sequences of viral genome, especially from a highly conserved domain of enteroviral genome as templates to design target small ligand RNAs (sliRNAs). The resulting sliRNAs are therapeutically active ingredients in the treatment of the related diseases caused by pathological angiogenesis. | 03-22-2012 |
20120232126 | MULTI-TARGETS INTERFERING RNA MOLECULES AND THEIR APPLICATIONS - This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function. | 09-13-2012 |
20130210894 | APPLICATION OF HIGHLY CONSERVED DOMAIN SEQUENCES FROM VIRAL GENOME AS TEMPLATE TO DESIGN THERAPEUTIC SLIRNAS - This invention relates to the application of the highly conserved sequences of viral genome, especially from a highly conserved domain of enteroviral genome as templates to design target small ligand RNAs (sliRNAs). The resulting sliRNAs are therapeutically active ingredients in the treatment of the related diseases caused by pathological angiogenesis. | 08-15-2013 |
20130296401 | HBV TREATMENT - RNA interference (RNAi) agents and the use of the RNAi agents for treating hepatitis B infection in individuals, as well as pharmaceutical compositions containing the RNAi agents are provided. The RNAi agents, or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene, wherein each agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some embodiments of the present invention, the agents have more than one effector sequence; wherein the multiple effectors may target the same region of an HBV gene, different (possibly overlapping) regions of the same gene and/or different HBV genes. | 11-07-2013 |
York Yuan Yuan Zhu, Palo Alto, CA US
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20090099043 | Construction of pool of interfering nucleic acids covering entire RNA target sequence and related compositions - The present invention provides a PCR based high-throughput method for preparing full-sites siRNA polynucleotide pool, comprising: DNase I random digestion; Loop-1 phosphate linker ligation; single PCR amplification; a type III restriction/modification enzyme digestion; blunt ending; Loop-2 phosphate linker ligation; double primer PCR; FokI digestion and cloning into an siRNA expression vector. The present invention enables the use of a type III restriction/modification enzyme linkers mediated PCR method for high-throughput preparing an siRNA polynucleotide pool, in which the functional length of siRNAs can be controllably distributed from 19-23 bp, thus completely mimic the natural siRNA length diversity, specially suitable for RNAi therapeutic targets screening. The present invention overcomes the bottlenecks and drawbacks of conventional siRNA polynucleotide pool construction technologies. | 04-16-2009 |
Youding Zhu, Palo Alto, CA US
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20090175540 | Controlled human pose estimation from depth image streams - A system, method, and computer program product for estimating upper body human pose are described. According to one aspect, a plurality of anatomical features are detected in a depth image of the human actor. The method detects a head, neck, and torso (H-N-T) template in the depth image, and detects the features in the depth image based on the H-N-T template. An estimated pose of a human model is estimated based on the detected features and kinematic constraints of the human model. | 07-09-2009 |