Patent application number | Description | Published |
20140094409 | ANTAGONIST FOR (PRO)RENIN RECEPTOR FOR THE TREATMENT OF HYPERTENSION AND DIABETES - Brain prorenin and the (pro)renin receptor (PRR) have a functional role in the development of hypertension. The present disclosure presents functional PRR antagonistic peptides (e.g., PR10, PR20, PR30, and PR40). In addition, modified peptides comprising one or more thioether-bridges that are stable and strong PRR antagonists are also provided. Methods for treating and preventing hypertension, including neurogenic hypertension, and diabetes with a PRR antagonist are also provided. | 04-03-2014 |
20150025013 | Compositions And Methods Of Use For (PRO)Renin Receptor - Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin receptor (PRR) antagonist. In some instances the PRR antagonist is a polypeptide. The PRR antagonist can be a polypeptide having at least 70% identity to the amino acid sequence set forth in SEQ ID NO:2. Also disclosed are methods of decreasing proteinuria and methods of promoting wound healing by administering a PRR antagonist. | 01-22-2015 |
20150252074 | Antagonist for (Pro)Renin Receptor for the Treatment of Hypertension and Diabetes - Methods and compositions for increasing a plant's resistance to an insect pest such as the corn rootworm are provided. Methods are provided for overexpression of Crw2, or variants thereof, in a host plant or plant cell to increase resistance to an insect pest in a plant such as maize. Methods are also provided for identifying variants of Crw2 that when incorporated into a plant via transgenic or traditional breeding means increase resistance to an insect pest in a plant such as maize. Also provided are methods for increasing resistance by overexpressing Crw1 and Crw2. | 09-10-2015 |
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20130165019 | COMPUTER NUMERICAL CONTROL MACHINE TOOL FOR GRINDING TWO SIDES OF A PLANE BY SHIFTING SELF-ROTATION AND ULTRASONIC VIBRATION - A computer numerical control machine tool for grinding two sides of a plane by shifting self-rotation ultrasonic vibration, wherein a pillar ( | 06-27-2013 |
20140298668 | DEVICE FOR DETECTING AXIS COPLANARITY OF ORTHOGONAL ROTARY SHAFTS HAVING BUILT-IN INTERSECTION AND PRECISION DETECTING METHOD - The present invention discloses a device for detecting axis coplanarity of orthogonal rotary shafts having a built-in intersection, wherein a front assembly rotary body is coaxially connected on a front assembly housing, the front assembly rotary body and a rear assembly housing are fixedly connected with each other, the rear assembly rotary body is mounted in the rear assembly housing, a first three dimension movement fine tuning mechanism is mounted at an end of the rear assembly rotary body, the first three dimension movement fine tuning mechanism is connected with a standard sphere through a connecting rod, the three dimension movement fine tuning mechanisms are provided in the horizontal direction of the standard sphere and below the standard sphere in vertical direction, and two non-contact displacement sensors are mounted on said two three dimension movement fine tuning mechanisms respectively. The present invention also discloses a precision measurement method for measuring axis coplanarity of the orthogonal rotary shafts having a built-in intersection by using the above device, having a feature of high measurement precision, which is adaptive to coplanarity detections for the cantilever-type orthogonal shafts having a built-in intersection and the clamp-type orthogonal shafts having a built-in intersection. | 10-09-2014 |
20150122058 | MACRO-MICRO ACTUATED DISTENDED GUIDE RAIL PRECISION ROTATION APPARATUS - A macro-micro actuated distended guide rail precision rotation apparatus, having a housing of a torque motor and a bearing housing, both fixedly arranged on an upper surface of a base, and a bearing sleeved on the bearing housing. The inner ring of the bearing sleevingly connected to an intermediate rotating body connected to a bearing inner ring cap. A grating is provided at a lower end of the bearing inner ring cap. A connecting piece is arranged on the upper surface of the housing of the torque motor. The lower end of the connecting piece is fixedly connected to a rotary shaft of the torque motor. The connecting piece and the intermediate rotating body are both connected to the lower end of a fine movement mechanism fixedly connected to a rotary worktable. The rotation apparatus allows for highly precise macro-and-micro linked control, and for rotation control of great rotation range. | 05-07-2015 |
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20120322978 | CROSSLINKING REAGENTS, METHODS, AND COMPOSITIONS FOR STUDYING PROTEIN-PROTEIN INTERACTIONS - The invention provides reagents, methods, and compositions for studying protein-protein interactions. The inventive system and methods allow the analysis of protein-protein interactions in vivo and in vitro. Advantages offered by various embodiments of the inventive system and methods compared to existing photocrosslinking approaches include, for example, (i) novel reversible crosslinking reagents that allow easy isolation, purification, and enrichment of the crosslinked products; (ii) trifluoromethyl phenyldiazirine- or perfluorinated phenylazide-based photocrosslinking reagents that provide high specific labeling, no side product, and higher photocrosslinking efficiency; (iii) versatile spacer groups that allow systematic contact site mapping; (iv) novel methods for isolating, purifying, and detecting crosslinked products based on the reversible-link chemistry; and (v) the ability to study the interaction sites in vitro, in situ, or in vivo. | 12-20-2012 |
20140206903 | NOVELCROSSLINKING REAGENTS, MACROMOLECULES, THERAPEUTIC CONJUGATES, AND SYNTHETIC METHODS THEREOF - The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a single and pure form. The molecular weights of these molecules range from small (<1000 Da) to large (1000-120,000 Da). The sugar alcohol-based molecules can have functional groups throughout the molecule for crosslinking compounds, such as the preparation of antibody-drug conjugates, or to facilitate the delivery of therapeutic proteins, peptides, siRNA, and chemotherapeutic drugs. Also provided are new conjugate entities prepared through sugar alcohol molecules. Methods of synthesizing sugar alcohol-based molecules and conjugates are also within the scope of the invention. | 07-24-2014 |
20150017246 | NOVEL CROSSLINKING REAGENTS, MACROMOLECULES, THERAPEUTIC BIOCONJUGATES, AND SYNTHETIC METHODS THEREOF - The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a single and pure form. The molecular weights of these molecules range from small (<1000 Da) to large (1000-120,000 Da). The sugar alcohol-based molecules can have functional groups throughout the molecule for crosslinking compounds, such as the preparation of antibody-drug conjugates, or to facilitate the delivery of therapeutic proteins, peptides, siRNA, and chemotherapeutic drugs. Also provided are new conjugate entities prepared through sugar alcohol molecules. Methods of synthesizing sugar alcohol-based molecules and conjugates are also within the scope of the invention. | 01-15-2015 |
20160052942 | TRIFLUOROBORATE MASS SPECTROMETRIC TAGS - The invention provides compositions and methods for mass spectrometric (MS), organic synthesis, and applications of organo-trifluoroborate, for example, as mass tags for use in negative ion mode. When subject to MS fragmentation, organo-trifluoroborates preferentially undergo neutral losses of hydrogen fluoride (HF) or boron trifluoride (BF | 02-25-2016 |
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20130111981 | MULTI-AXLE JOINT SHIFTING LOADING APPARATUS FOR PROCESSING CENTER AND DETECTION METHOD FOR STATIC STIFFNESS DISTRIBUTION - Disclosed is a processing center multi-axis joint deflection loading apparatus comprising a load-receiving test piece and a load-exerting component. The load-exerting component is constituted by a steel ball, a cap, a ball socket, a bent board, a force sensor, a connection component A, and a connection component B. The connection component A is fixedly connected to a blade handle of the processing center; the blade handle is pulled tight within a bored hole on a main axle; and the connection component A is connected to a main housing via the connection component B. In a method using the apparatus for an inspection of static stiffness distribution, by means of a multi-axle joint movement, moving the load-exerting component and the load-receiving test piece to a preset loading position, allowing the normal at a load-receiving point on a load-receiving face of the load-receiving piece to be aligned with the axis of the ball socket; with the amount of shift measured by position-shift sensors fitted on the main axle, the main axle housing, and a working platform, and the amount of simulated load measured by the force sensor of the loaded-exerting component, deriving a stiffness measurement of the load-exertion position under a simulated load; changing the load-exertion position by means of a multi-axle joint movement, repeating in sequence the previous steps, thus deriving a stiffness distribution under the simulated load. | 05-09-2013 |
20130115857 | TRANSLOCATION-SIMULATING LOADING APPARATUS FOR GEAR GRINDING MACHINE WITH SHAPED GRINDING WHEEL AND DETECTION METHOD FOR STIFFNESS DISTRIBUTION - A translocation-simulating loading apparatus for gear grinding machine with shaped grinding wheel is provided. The apparatus comprises a load-receiving test piece ( | 05-09-2013 |
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20080199545 | Anti-resorptive and bone building dietary supplements and methods of use - Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, | 08-21-2008 |
20080199546 | Anti-resorptive and bone building dietary supplements and methods of use - Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth and, decreasing or preventing bone resorption comprising a first composition comprising a combination of at least two of: quercetin, | 08-21-2008 |
20140147526 | ANTIOXIDANT DIETARY SUPPLEMENT AND RELATED METHOD - A supplement including a blend of turmeric, quercetin and rosemary, or holy basil, wasabi, and broccoli seed extract which are present in a balanced and predetermined ratio, and which stimulate the Antioxidant Response Element (ARE), Quinone Reductase, and/or induce related gene expression, for example, heme oxygenase-1 (HMOX-1) expression. The blend of ingredients can be formed as or in a dietary supplement adapted for administration to a subject. The dietary supplement can be formulated so that the turmeric, quercetin and rosemary are present in a predetermined ratio of 1:3:5, or holy basil, wasabi, and broccoli seed extract in a predetermined ratio of 1:1:0.2. Additional ingredients can be included in the supplement. The supplement can synergistically affect natural antioxidant response pathways within cells of a subject to whom the supplement is administered. A related method of use is also provided. | 05-29-2014 |
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20150136035 | FOLDED ANIMAL EXCRETION DISPOSAL SHEET - A folded animal excretion disposal sheet formed by folding an animal excretion disposal sheet having a rectangular shape with a first pair of lateral edges and a second pair of lateral edges, the animal excretion disposal sheet includes an outer peripheral joining portion in which a top sheet and back sheet are joined, and a central absorbent body portion in which an absorbent body is disposed between the top and back sheet; a fragrance ingredient is applied to the top sheet and/or absorbent body; the folded animal excretion disposal sheet is folded along a folding line parallel to the first pair of lateral edges, such that the top sheet is not exposed to an outer surface; and a plurality of the outer peripheral joining portions, composing the second pair of lateral edges after folding, are temporarily joined to each other to thereby form a pair of temporary joining portions. | 05-21-2015 |
20150320009 | ABSORBENT SHEET FOR PETS - An absorbent sheet for pets that is highly effective in concealing pet excrement. The absorbent sheet includes: a liquid-permeable front-surface sheet; a liquid-impermeable back-surface sheet; an absorbent body that is provided between the front-surface sheet and the back-surface sheet, and that absorbs liquid that has permeated through the front-surface sheet; an intermediate sheet that is arranged between the front-surface sheet and the absorbent body; and a color arrangement region that forms a color arrangement pattern together with at least one of the front-surface sheet, the back-surface sheet, and the absorbent body. The front-surface sheet is formed so as to have a lower total light transmittance than the intermediate sheet. | 11-12-2015 |
20150334985 | ABSORBENT SHEET FOR PETS - An absorbent sheet for pets which has a strong pet-excrement concealing effect, and makes it possible to recognize the time for an exchange of the pet sheet. The absorbent sheet has an excrement surface, a placement surface, a body-outer-edge section, an outside direction, an inside direction, an absorbent, an absorbent-outer-edge section, an absorbent-outer-edge region which is a region containing the absorbent-outer-edge section, an absorbent-center region formed in the inside direction in relation to the absorbent-outer-edge region, and a color-scheme region which is recognizable from the excrement-surface side. The color-scheme region has a first color-scheme region, a second color-scheme region and a third color-scheme region, and forms a color-scheme pattern from the first color-scheme region, the second color-scheme region and the third color-scheme region. | 11-26-2015 |
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20140147412 | SPIRO COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS - Disclosed are spiro compounds of formula (I), or stereomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof. The compounds can be used to treat hepatitis C virus (HCV) infection or hepatitis C disease. Furthermore disclosed are pharmaceutical compositions containing the compounds and the method of using the compounds or pharmaceutical compositions in the treatment of HCV infection or hepatitis C disease. | 05-29-2014 |
20150079028 | Bridged Ring compounds As Hepatitis C Virus (HCV) Inhibitors And Pharmaceutical Applications Thereof - Provided herein is a compound having Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or a HCV disorder. Also provided herein are pharmaceutical compositions comprising the compounds disclosed herein, which can be used for treating HCV infection or a HCV disorder. | 03-19-2015 |