Patent application number | Description | Published |
20090048254 | SALTS AND POLYMORPHS OF A VEGF-R INHIBITOR - The invention relates to salts and free base forms of N,2-dimethyl-6-[7-(2-morpholinoethoxy)quinolin-4-yloxy]benzofuran-3-carboxamide. The invention further relates to pharmaceutical compositions of these salts and free base forms and methods of treating disorders such as cancer using such compositions. | 02-19-2009 |
20090069316 | NOVEL QUINOLINE DERIVATIVES - The invention relates to compounds represented by Formula (I): | 03-12-2009 |
20090318440 | CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS - Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4. | 12-24-2009 |
20100222342 | PYRROLOPYRAZOLE, POTENT KINASE INHIBITORS - Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4. | 09-02-2010 |
20100249128 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H,4H,6H) CARBALDEHYDE DERIVATIVES - The present invention relates to compounds and pharmaceutically acceptable salts of Formula (I): wherein X, R | 09-30-2010 |
20120108588 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES - The present invention relates to compounds and pharmaceutically acceptable salts of Formula (I): | 05-03-2012 |
20120264751 | PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS - Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4. | 10-18-2012 |
20150105539 | Drug-Conjugates, Conjugation Methods, and Uses Thereof - In one aspect, an active agent-conjugate, methods of preparing the active agent-conjugate, and uses thereof is provided. | 04-16-2015 |
20150105540 | DRUG-CONJUGATES WITH A TARGETING MOLECULE AND TWO DIFFERENT DRUGS - There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second drug conjugate with a different drug to a Lys residue on the targeting protein. | 04-16-2015 |