Patent application number | Description | Published |
20090275496 | Effective quantitation of complex peptide mixtures in tissue samples and improved therapeutic methods - The instant invention provides methods for the detection and quantitation of complex peptide mixtures in tissue samples and functional readouts of the results of administration of such complex peptide mixtures. The instant invention further provides methods for administering complex peptide mixtures to a subject in need thereof, the dosage regimen and quantity determined based on the above mentioned method for detection and quantitation. | 11-05-2009 |
20100316714 | METHODS OF TREATING DISEASE WITH RANDOM COPOLYMERS - The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein. | 12-16-2010 |
20140249089 | METHODS OF TREATING DISEASE WITH RANDOM COPOLYMERS - The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein. | 09-04-2014 |
Patent application number | Description | Published |
20090068255 | USE OF MATRIX METALLOPROTEINASE INHIBITORS IN SKIN CARE - The application of matrix metalloproteinase (MMP) inhibitors to the skin inhibits the degradation of proteins found in the skin including collagen, elastin, and other basement membrane and extracellular matrix protein. MMP inhibitors may be used in both cosmetic compositions and pharmaceutical compositions for application to skin. MMP inhibitors are formulated with a cosmetically suitable vehicle or pharmaceutically acceptable excipient for application to the skin as creams, lotions, ointments, solutions, face masks, etc. As cosmetics, the inventive MMP inhibitor compositions are applied to the skin to prevent or reduce the appearance of wrinkles, pigmentation changes, loss of elasticity, or other effects associated with aging or sun damage. As pharmaceuticals, the inventive MMP inhibitor compositions may also be applied to the skin to treat or prevent a skin disease (e.g., proliferative disease, inflammatory disease). | 03-12-2009 |
20090145452 | DEVICES AND METHODS OF USE FOR TREATMENT OF SKIN AND HAIR - Devices and methods of use are disclosed for treating hair and/or skin. The devices include light sources or heat sources useful in activating polymerization initiators thereby polymerizing monomers in situ on skin or hair. Exemplary devices include hair brushes, eyelash brushes, curling irons, curlers, and flat irons. | 06-11-2009 |
20090194125 | ULTRASOUND HAIR TREATMENT - The present invention relates to methods for the ultrasound enhancement of hair treatments, and to compositions and kits relating to said method. The invention further relates to ultrasonic devices for use in the methods. | 08-06-2009 |
20090220436 | IN SITU POLYMERIZATION FOR SKIN TREATMENT - Cosmetics represent a world-wide multi-billion dollar industry. The present invention provides technology for polymerizing monomers on skin in situ to produce desired skin characteristics. For example, the inventive system may be used to reduce the signs of aging or to protect the treated skin from UV light. The polymerization of monomers on skin is typically initiated using a thermal or photoinitiatied free radical initiator. In certain embodiments, the monomers are fluorinated thereby producing a fluorinated polymer on the skin upon polymerization. The invention provides monomers, initiators, methods, and kits for use in treating skin with polymers. | 09-03-2009 |
20120237461 | SKIN COMPOSITIONS AND METHODS OF USE THEREOF - Provided are therapeutic formulations and methods of use thereof. | 09-20-2012 |
20120251600 | SKIN COMPOSITIONS AND METHODS OF USE THEREOF - Provided are body corrective cosmetic formulations and methods of use thereof. | 10-04-2012 |
20130078209 | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS OF COMPROMISED SKIN BARRIER FUNCTION - Compositions and methods of treating conditions of compromised skin barrier function are described. | 03-28-2013 |
20140004073 | SKIN COMPOSITIONS AND METHODS OF USE THEREOF | 01-02-2014 |
20140010769 | COLOR CORRECTING COMPOSITIONS AND METHODS OF USE THEREOF - Compositions and methods of for changing the color of skin or body are described. | 01-09-2014 |
20140044670 | SKIN COMPOSITIONS AND METHODS OF USE THEREOF - Provided are therapeutic formulations and methods of use thereof. | 02-13-2014 |
Patent application number | Description | Published |
20120082338 | ATTITUDE ESTIMATION BY REDUCING NOISE WITH DRAGBACK - In general, in one embodiment, a starfield image as seen by an object is analyzed. Compressive samples are taken of the starfield image and, in the compressed domain, processed to remove noise. Stars in the starfield image are identified and used to determine an attitude of the object. | 04-05-2012 |
20120082345 | ATTITUDE ESTIMATION IN COMPRESSED DOMAIN - In general, in one embodiment, a starfield image as seen by an object is analyzed. Compressive samples are taken of the starfield image and, in the compressed domain, processed to remove noise. Stars in the starfield image are identified and used to determine an attitude of the object. | 04-05-2012 |
20120082393 | ATTITUDE ESTIMATION WITH COMPRESSIVE SAMPLING OF STARFIELD DATA - In general, in one embodiment, a starfield image as seen by an object is analyzed. Compressive samples are taken of the starfield image and, in the compressed domain, processed to remove noise. Stars in the starfield image are identified and used to determine an attitude of the object. | 04-05-2012 |
20120127029 | CODED FILTER - A method and apparatus for estimating and compensating for a broad class of non-Gaussian sensor and process noise. In one example, a coded filter combines a dynamic state estimator (for example, a Kalman filter) and a non-linear estimator to provide approximations of the non-Gaussian process and sensor noise associated with a dynamic system. These approximations are used by the dynamic state estimator to correct sensor measurements or to alter the dynamic model governing evolution of the system state. Examples of coded filters leverage compressive sensing techniques in combination with error models based on concepts of compressibility and the application of efficient convex optimization processes. | 05-24-2012 |
20120280108 | SYSTEMS AND METHODS FOR ADDING OR SUBTRACTING PIXELS - A pixel array including circuitry for combining charges accumulated by individual pixels in the array enables addition and/or subtraction of individual pixel values, prior to their digitization, in the pixel array. | 11-08-2012 |
Patent application number | Description | Published |
20090299213 | Nanobioelectronics - The present invention generally relates to nanobioelectronics and, in some cases, to circuits comprising nanoelectronic elements, such as nanotubes and/or nanowires, and biological components, such as neurons. In one aspect, cells, such as neurons, are positioned in electrical communication with one or more nanoscale wires. The nanoscale wires may be used to stimulate the cells, and/or determine an electrical condition of the cells. More than one nanoscale wire may be positioned in electrical communication with the cell, for example, in distinct regions of the cell. However, the nanoscale wires may be positioned such that they are relatively close together, for example, spaced apart by no more than about 200 nm. The nanoscale wires may be disposed on a substrate, for example, between electrodes, and the cells may be adhered to the substrate, for example, using cell adhesion factors such as polylysine. Also provided in other aspects of the invention are methods for making and using such devices, kits for using the same, and the like. | 12-03-2009 |
Patent application number | Description | Published |
20100143582 | LIQUID FILMS CONTAINING NANOSTRUCTURED MATERIALS - The present invention generally relates to liquid films containing nanostructured materials, and, optionally, the use of this arrangement to organize nanostructures and to transfer the nanostructures to a surface. Liquid films containing nanostructures, such as nanoscale wires, can be formed in a gas such as air. By choosing an appropriate liquid, a liquid film can be expanded, for example to form a “bubble” having a diameter of at least about 5 cm or 10 cm. The size of the bubble can be controlled, in some cases, by controlling the viscosity of the liquid film. In some embodiments, the viscosity can be controlled to be between about 15 Pa s and about 25 Pa s, or controlled using a mixture of an aqueous liquid and an epoxy. In some cases, the film of liquid may be contacted with a surface, which can be used to transfer at least some of the nanostructures to the surface. In some cases, the nanostructures may be transferred as an orderly or aligned array. Once on the surface, the nanostructures may be reacted, etched, layered, etc., e.g., for use in an electric circuit. | 06-10-2010 |
20110001117 | NANOSCALE WIRE-BASED MEMORY DEVICES - The present invention generally relates to nanotechnology and sub-microelectronic devices that can be used in circuitry, and, in particular, to nanoscale wires and other nanostructures able to encode data. One aspect of the present invention is directed to a device comprising an electrical crossbar array comprising at least two crossed wires at a cross point. In some cases, at least one of the crossed wires is a nanoscale wire, and in certain instances, at least one of the crossed wires is a nanoscale wire comprising a core and at least one shell surrounding the core. For instance, the core may comprise a crystal (e.g., crystalline silicon) and the shell may be at least partially amorphous (e.g., amorphous silicon). In certain embodiments, the cross point may exhibit intrinsic current rectification, or other electrical behaviors, and the cross point can be used as a memory device. For example, in one embodiment, the cross point may exhibit a first conductance at a positive voltage, and the cross point may exhibit a second conductance at a negative voltage. Accordingly, by applying suitable voltages to the cross point, data may be stored at the cross point. Other aspects of the present invention are directed to systems and methods for making or using such devices, kits involving such devices, or the like. | 01-06-2011 |
Patent application number | Description | Published |
20110294801 | MACROCYCLICS PYRIMIDINES AS AURORA KINASE INHIBITORS - Macrocyclic derivative compounds that inhibit protein kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and/or disturbed kinase activity such as cancers, psoriasis, viral and bacterial infections, inflammatory and autoimmune diseases. | 12-01-2011 |
20130023522 | BENZAMIDES - Novel benzamide derivatives of formula (I) | 01-24-2013 |
20130172351 | Dihydropyrazoles - Novel dihydropyrazole derivatives of formula (I) | 07-04-2013 |
20130184314 | Novel Phenylamino Isonicotinamide Compounds - The invention provides novel compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. | 07-18-2013 |
20140243370 | Pyrano[3,2-D][1,3]thiazole as glycosidase inhibitors - Novel compounds of formula (I) | 08-28-2014 |
20140296238 | Dihydropyrazoles - Novel dihydropyrazole derivatives of formula (I) | 10-02-2014 |
20150018318 | Glycosidase inhibitors - Novel compounds of formula (I) | 01-15-2015 |
20150025066 | CYCLIC DIAMINOPYRIMIDINE DERIVATIVES - Compounds of the formula I | 01-22-2015 |
Patent application number | Description | Published |
20100014799 | Optical structures including nanocrystals - An optical structure can include a nanocrystal on a surface of an optical waveguide in a manner to couple the nanocrystal to the optical field of light propagating through the optical waveguide to generate an emission from the nanocrystal. | 01-21-2010 |
20120327052 | LED ARRAY WITH PHOTODETECTOR - Embodiments of the present invention provide for an array, and corresponding method of forming an array, that includes a plurality of light emitting devices. The light emitting devices are disposed over a substrate, and a photodetector detects light emitted through the substrate from the light emitting devices. Further, a substantially constant brightness may be maintained in a plurality of light emitting devices disposed over the upper surface of a substrate in an array. Light emitted through the substrate from each of the light emitting devices is measured, and the voltage level applied to each of the light emitting devices is varied to maintain a substantially constant brightness level of light emitted from the light emitting devices. | 12-27-2012 |
20130181962 | LED ARRAY WITH PHOTODETECTOR - Embodiments of the present invention provide for an array, and corresponding method of forming an array, that includes a plurality of light emitting devices. The light emitting devices are disposed over a substrate, and a photodetector detects light emitted through the substrate from the light emitting devices. Further, a substantially constant brightness may be maintained in a plurality of light emitting devices disposed over the upper surface of a substrate in an array. Light emitted through the substrate from each of the light emitting devices is measured, and the voltage level applied to each of the light emitting devices is varied to maintain a substantially constant brightness level of light emitted from the light emitting devices. | 07-18-2013 |
Patent application number | Description | Published |
20090191071 | Compressors - Compressors are provided which include a motor having a drive shaft; a compression chamber, having an inlet and an outlet; a diaphragm, disposed within the compression chamber such that when the diaphragm is deflected back and forth between a first position and a second position air is drawn in through the inlet and forced out through the outlet; a crankshaft, operatively connected to the drive shaft; a shuttle, configured to be displaced transversely by rotational movement of the crankshaft, and positioned to deflect the diaphragm by its transverse movement; and a guide configured to inhibit non-transverse motion of the shuttle. In some implementations, the compressor occupies a total volume of less than about 15 cubic inches. | 07-30-2009 |
20110061189 | ORAL CARE PRODUCTS AND METHODS OF USING AND MAKING THE SAME - An oral care implement may include a base portion sized for insertion into an oral cavity and a plurality of flexible, elastomeric elements extending from the base portion, wherein each of the plurality of flexible, elastomeric elements comprises an edge, wherein at least one of the edges comprises a micro edge, and wherein the plurality of flexible, elastomeric elements comprises an element density of less than about 5 mm. Another embodiment of an oral care implement may include a base portion sized for insertion into an oral cavity and a plurality of flexible, elastomeric elements extending from the base portion, wherein at least one of the plurality of flexible, elastomeric elements comprises a first section having a first section edge and a first transverse cross sectional area, and a second section disposed adjacent to the first section along a longitudinal axis of the at least one of the plurality of flexible, elastomeric elements, the second section having a second section edge and a second transverse cross sectional area different from the first transverse cross sectional area. Yet another embodiment of an oral care implement includes a base portion sized for insertion into an oral cavity, the base portion having a base wall and two opposed, side walls connected to the base wall that form a channel for receiving teeth within an oral cavity and a plurality of flexible, elastomeric elements extending into the channel from the base and two opposed, side walls. | 03-17-2011 |
20130055513 | Oral Care Products And Methods Of Using And Marking The Same - An oral care implement may include a base portion sized for insertion into an oral cavity and a plurality of flexible, elastomeric elements extending from the base portion, wherein each of the plurality of flexible, elastomeric elements comprises an edge, wherein at least one of the edges comprises a micro edge, and wherein the plurality of flexible, elastomeric elements comprises an element density of less than about 5 mm. | 03-07-2013 |
Patent application number | Description | Published |
20100226134 | Methods and Apparatus for Improving Collimation of Radiation Beams - An apparatus for collimating radiation can include an aperture of subwavelength dimensions and a neighboring set of grooves defined on a metal film integrated with an active or passive device that emits radiation. Integration of the beam collimator onto the facet of a laser or other radiation-emitting device provides for beam collimation and polarization selection. Beam divergence can be reduced by more than one order of magnitude compared with the output of a conventional laser. An active beam collimator with an aperture-groove structure can be integrated with a wide range of optical devices, such as semiconductor lasers (e.g., quantum cascade lasers), light emitting diodes, optical fibers, and fiber lasers. | 09-09-2010 |
20110315898 | Plasmonic Polarizer - A radiation-emitting device (e.g., a laser) includes an active region configured to generate a radiation emission linearly polarized along a first polarization direction and a device facet covered by an insulating layer and a metal layer on the insulating layer. The metal layer defines an aperture through which the radiation emission from the active region can be transmitted and coupled into surface plasmons on the outer side of the metal layer. The long axis of the aperture is non-orthogonal to the first polarization direction, and a sequential series of features are defined in or on the device facet or in the metal layer and spaced apart from the aperture, wherein the series of features are configured to manipulate the surface plasmons and to scatter surface plasmons into the far field with a second polarization direction distinct from the first polarization direction. | 12-29-2011 |
20130266034 | METHODS AND APPARATUSES FOR ENGINEERING ELECTROMAGNETIC RADIATION - laser devices described may emit a beam of electromagnetic radiation having a large wavelength (e.g., mid-infrared, far-infrared) and exhibiting a low angle of divergence. In some embodiments, the wavelength of the electromagnetic radiation is between | 10-10-2013 |
Patent application number | Description | Published |
20100093760 | METHODS FOR IDENTIFYING COMPOUNDS THAT MODULATE CELL SIGNALING AND METHODS EMPLOYING SUCH COMPOUNDS - The invention provides methods for identifying compounds that modulate cell signaling, as well as therapeutic methods that employ such compounds. | 04-15-2010 |
20110053930 | INHIBITORS OF THE BMP SIGNALING PATHWAY - The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. | 03-03-2011 |
20140011805 | INHIBITORS OF THE BMP SIGNALING PATHWAY - The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. | 01-09-2014 |
20140038953 | COMPOSITIONS AND METHODS FOR CARDIOVASCULAR DISEASE - The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to reduce circulating levels of ApoB-100 or LDL. These compounds may also be used to treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia. | 02-06-2014 |
Patent application number | Description | Published |
20110244616 | VERTICAL STRUCTURE LED CURRENT SPREADING BY IMPLANTED REGIONS - An improved method of fabricating a vertical semiconductor LED is disclosed. Ions are implanted into the LED to create non-conductive regions, which facilitates current spreading in the device. In some embodiments, the non-conductive regions are located in the p-type layer. In other embodiments, the non-conductive layer may be in the multi-quantum well or n-type layer. | 10-06-2011 |
20110263054 | BOND PAD ISOLATION AND CURRENT CONFINEMENT IN AN LED USING ION IMPLANTATION - An improved method of creating LEDs is disclosed. Rather than using a dielectric coating to separate the bond pads from the top surface of the LED, this region of the LED is implanted with ions to increase its resistivity to minimize current flow therethrough. In another embodiment, a plurality of LEDs are produced on a single substrate by implanting ions in the regions between the LEDs and then etching a trench, where the trench is narrower than the implanted regions and positioned within these regions. This results in a trench where both sides have current confinement capabilities to reduce leakage. | 10-27-2011 |
20110275173 | ISOLATION BY IMPLANTATION IN LED ARRAY MANUFACTURING - An improved method of creating LED arrays is disclosed. A p-type layer, multi-quantum well and n-type layer are disposed on a substrate. The device is then etched to expose portions of the n-type layer. To create the necessary electrical isolation between adjacent LEDs, an ion implantation is performed to create a non-conductive implanted region. In some embodiments, an implanted region extends through the p-type layer, MQW and n-type layer. In another embodiment, a first implanted region is created in the n-type layer. In addition, a second implanted region is created in the p-type layer and multi-quantum well immediately adjacent to etched n-type layer. In some embodiments, the ion implantation is done perpendicular to the substrate. In other embodiments, the implant is performed at an angle. | 11-10-2011 |
Patent application number | Description | Published |
20090161150 | LASER COLOR COPY IMAGE PROCESSING INDEPENDENT OF CLASSIFICATIONS - An apparatus and a method are described for processing and reproducing a document including both text and half-tone images without generating undesirable image artifacts. A band-pass FIR filter with a predetermined frequency response is used to transform pixels in an input image to sharpen text edge and smooth pre-half-toned areas, and perform error diffusion and cluster dot screening methods on the transformed pixels. The FIR filter has unity gain at DC to preserve image brightness. An integrated error diffused cluster-dot screening approach is used to suppress moiré and other image artifacts, while providing a robust, crisp output. | 06-25-2009 |
20110075166 | PREVIEW OF A DOCUMENT WITH PRINTABLE COMPONENTS AT A PRINTING DEVICE BASED ON ITS PRINTING CAPABILITY - An apparatus, method, system and medium are described that support functionality to receive document(s) to be printed at a printing device, and enable editing the document(s) prior to printing. Modifications to the document(s) may be generated based on the user edits, and a print preview of the modified documents may be displayed and may enable further edits. In some embodiments, the print preview may be provided to the user on a display that is part of the printing device. In some embodiments, the print preview may be provided to the user through a UI presented on a client device. Display of the modified document(s) may be a rasterized image of the modified document(s), generated based on capabilities of a selected printing device. In some embodiments, modifications may be made to an intermediate version of the document(s), and that intermediate version may be cached. | 03-31-2011 |
20110075200 | PREVIEW AND MODIFICATION OF PRINTABLE COMPONENTS OF A DOCUMENT AT A PRINTING DEVICE - An apparatus, method, system and medium are described that support functionality to receive document(s) to be printed at a printing device, and enable editing the document(s) prior to printing. Modifications to the document(s) may be generated based on the user edits, and a print preview of the modified documents may be displayed and may enable further edits. In some embodiments, the print preview may be provided to the user on a display that is part of the printing device. In some embodiments, the print preview may be provided to the user through a UI presented on a client device. Display of the modified document(s) may be a rasterized image of the modified document(s), generated based on capabilities of a selected printing device. In some embodiments, modifications may be made to an intermediate version of the document(s), and that intermediate version may be cached. | 03-31-2011 |
20120307266 | THREE COLOR NEUTRAL AXIS CONTROL IN A PRINTING DEVICE - A color printing method includes converting source color data to intermediate color data represented in a device independent color space using a first multidimensional gamut mapping of the first device dependent color space to the device independent color space. The device independent color space has a neutral color component. The method further includes converting the intermediate color data to destination color data represented in a second device dependent color space using a second multidimensional gamut mapping of the device independent color space to the second device dependent color space. The second device dependent color space has three primary color components and a virtual black color component defined by substantially equal tonal values of the three primary color components. The second multidimensional gamut mapping includes a mapping from the neutral color component of the device independent color space to the virtual black color component of the second device dependent color space. | 12-06-2012 |
Patent application number | Description | Published |
20100273765 | Rifamycin analogs and uses thereof - The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3′-hydroxy analogs, 4′- and/or 6′ halo and/or alkoxy analogs, and various 5′ substituents that incorporate a cyclic amine moiety. | 10-28-2010 |
20120129828 | S1P1 RECEPTOR AGONISTS AND USE THEREOF - The present invention relates to compounds of Formula (I) that are have activity as S1P1 receptor modulating agents, more specifically to specifically compounds that are S1P1 receptor agonists. The invention also related to the use of such compounds to treat diseases associated with inappropriate S1P1 receptor activity such as autoimmune diseases. | 05-24-2012 |
20120225851 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES - The present invention relates to a chemotherapeutic cancer treatment in which compounds of Formula Ia′, Ib′, Ic′, or II′ (referred to as a group as BH3Is) are administered to a mammal for the treatment of B-cell Lymphoma or other hematopoietic cancers, including diseases associated with MCL-1. In another aspect, the invention provides a method for treating particular types of hematopoietic cancers, such as B-cell lymphoma, using a combination of one or more compounds selected from the group consisting of compounds or Formula Ia, Ib, Ic, or II in combination with other therapies, for example, a class of therapeutics known as 26S proteosome inhibitors, such as, for example, Bortezomib. In another aspect the present invention relates to autoimmune treatment with pharmaceutical compositions comprising one or more compounds of Formula Ia′, Ib′, Ic′, or II′. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have unique in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease. | 09-06-2012 |
Patent application number | Description | Published |
20080210614 | SEPARATION DEVICES AND METHOD FOR SEPARATING PHOSPHORYLATED PEPTIDES AND PROTEINS - Embodiments of the present invention are directed to articles of manufacture, devices, methods and apparatus for performing liquid chromatography featuring a chromatographic sorbent having one or more pentafluorophenyl groups, wherein said one or more pentafluorophenyl groups are a bonded phase on a sorbent selected from the group comprising silica, organic polymers or hybrid organic silane material and said pentafluorophenyl groups are in a mono-, bi-, and tridentate forms. | 09-04-2008 |
20100285596 | METHODS FOR ISOLATING FUNCTIONALIZED MACROMOLECULES - The invention provides methods of isolating, purifying, analyzing and/or detecting, functionalized macromolecules, e.g., peptides, phosphopeptides, polypeptides, proteins, oligonucleotides, or phospholipids in a sample, e.g., a biological mixture, using solid phase extraction with an alumina sorbent packed in a micro-elution plate. | 11-11-2010 |
20130011925 | Separation Devices and Method For Separating Phosphorylated Peptides and Proteins - Embodiments of the present invention are directed to articles of manufacture, devices, methods and apparatus for performing liquid chromatography featuring a chromatographic sorbent having one or more pentafluorophenyl groups, wherein said one or more pentafluorophenyl groups are a bonded phase on a sorbent selected from the group comprising silica, organic polymers or hybrid organic diene material and said pentafluorophenyl groups are in a mono-, bi-, and tridentate forms. | 01-10-2013 |
20140178915 | METHOD FOR SEPARATING PEPTIDES AND PROTEINS - Embodiments of the present invention are directed to articles of manufacture, devices, methods and apparatus for performing liquid chromatography featuring a chromatographic sorbent having one or more pentafluorophenyl groups, wherein said one or more pentafluorophenyl groups are a bonded phase on a sorbent selected from the group comprising silica, organic polymers or hybrid organic silane material and said pentafluorophenyl groups are in a mono-, bi-, and tridentate forms. | 06-26-2014 |
20140179011 | RAPID FLUORESCENCE TAGGING OF GLYCANS AND OTHER BIOMOLECULES WITH ENHANCED MS SIGNALS - Reagents comprising MS active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as N-glycans and uses thereof are taught and described. | 06-26-2014 |
20140242709 | RAPID FLUORESCENCE TAGGING OF GLYCANS AND OTHER BIOMOLECULES WITH ENHANCED MS SIGNALS - Reagents comprising MS active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as N-glycans and uses thereof are taught and described. | 08-28-2014 |
20140350263 | RAPID FLUORESCENCE TAGGING OF GLYCANS AND OTHER BIOMOLECULES WITH ENHANCED MS SIGNALS - Reagents comprising MS active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as N-glycans and uses thereof are taught and described. | 11-27-2014 |
Patent application number | Description | Published |
20110269161 | Methods, Compositions and Kits for High Throughput Kinase Activity Screening Using Mass Spectrometry and Stable Isotopes - A mass-spectrometry-based method and substrates are provided herein for large scale kinome activity profiling directly from crude lysates using 90 chemically synthesized peptide substrates with amino acid sequences derived from known phosphoproteins. Quantification of peptide phosphorylation rates was achieved via the use of stable isotope labeled synthetic peptides. Half of these peptides immediately or rapidly showed robust and site-specific phosphorylation after incubation with serum-starved HEK293 cell lysate. A method and substrates for obtaining 90 simultaneous activity measurements in a single-reaction format were developed and validated. Activating kinase pathways through insulin or EGF stimulation reproducibly altered the phosphorylation rates of peptides derived from known pathway protein substrates. While examining cell-cycle-specific activities with the panel, a peptide derived from phosphoinositide 3-kinase regulatory subunit demonstrated mitotic and tyrosine-specific phosphorylation, which was confirmed to be a Src kinase site in vivo. The kinome activity profiling strategy was successfully applied with lysates of each of: cells manipulated by various combination of mitogen stimulation, pharmacological perturbation and siRNA-directed kinase knockdown; seven different breast cancer cell lines treated with gefitinib; and each of normal and cancerous tissue samples from renal cell carcinoma patients. This method concurrently measures multiple peptide phosphorylation rates to provide a diagnostic fingerprint pattern for activated kinases, protein phosphatases, modulators of these enzymes, and pathways (kinome) from as little starting material as a few cells. | 11-03-2011 |
20130252950 | TARGETING MTOR SUBSTRATES IN TREATING PROLIFERATIVE DISEASES - Provided are over 300 mTOR kinase targets identified by a comprehensive phosphoproteomics assay. Methods of targeting mTOR kinase targets, methods to determine the level of mTOR activity by measuring the level of phosphorylation of an mTOR targeted phosphorylation site, methods for distinguishing different classes of mTOR activity in a cell based on phosphoproteomic analysis of mTOR-targeted proteins are also provided. Also provided is the classification of a hyperproliferative disease based on phosphoproteomic analysis of mTOR-targeted proteins, as well as the personalization of therapeutic methods for the treatment of hyperproliferative disease based on phosphoproteomics. Also provided are therapeutic methods including administering to a subject an mTOR inhibitor, an mTOR inhibitor and an additional kinase inhibitor, or a dual inhibitor of mTOR and an additional kinase based on the phosphorylation levels of mTOR targets determined in the subject. Some aspects of this invention relate to the discovery that GrblO is an mTOR-targeted tumor suppressor gene. | 09-26-2013 |