Patent application number | Description | Published |
20090233933 | Prostaglandin Transporter Inhibitors - Provided are methods of inhibiting prostaglandin transporter (PGT) activity in mammals. Also provided are methods of determining whether a test compound is an inhibitor of a prostaglandin transporter. Additionally provided are compounds that inhibit prostaglandin transporter activity, and pharmaceutical compositions of those compounds. Methods of inhibiting COX-2 in a mammal are also provided. Additionally, methods of treating pain or inflammation in a mammal are provided. | 09-17-2009 |
20090286693 | MICROARRAYS OF TAGGED COMBINATORIAL TRIAZINE LIBRARIES - Triazine linkers can be used to prepare universal small molecule chips for functional proteomics and sensors. These triazine linker compounds are prepared by making a first building block by adding a first amine by reductive amination of triazine, making a second building block by adding a second amine to cyanuric chloride, and combining the first and second building blocks by aminating the first building block onto one of the chloride positions of the second building block. These triazine linkers are then linked to a substrate for determining binding affinity of proteins. | 11-19-2009 |
20100239500 | SUBSTITUTED TRIAZINE COMPOUNDS FOR NERVE REGENERATION - A family of substituted triazine compounds is synthesized by combinatorial solid phase chemistry. These compounds were found to increase the growth of neurons/axons from central nervous system neurons that had been damaged, and can be used in methods and pharmaceutical compositions for treating injuries, diseases and conditions associated with nerve damage. | 09-23-2010 |
20100279340 | Imaging agents for protein misfolding - Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using pyrrolidine catalyzed reactions by solution-phase synthesis. Neutral styryl molecules are prepared using acetic anhydride catalyzed reactions, Horner-Emmons reactions or Wittig reactions. | 11-04-2010 |
20120128592 | SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) COMPOUNDS AND METHODS OF THEIR PREPARATION - A compound for detecting an analyte using Surface Enhanced Raman Spectroscopy (SERS) and a method of forming the compound is provided. The compound has Formula I: | 05-24-2012 |
20130101517 | DEVELOPMENT OF PHOTOSTABLE NEAR-IR CYANINE DYES FOR IN VIVO IMAGING - A compound of structural formula (I): | 04-25-2013 |
20130171171 | PROSTAGLANDIN TRANSPORTER INHIBITORS - The present invention generally relates to prostaglandin transport. More specifically, the invention is directed to compounds that inhibit prostaglandin transport and subsequent COX-2 induction, and methods relating thereto. | 07-04-2013 |
20130196057 | METHOD FOR PREPARING A SURFACE ENHANCED RAMAN SPECTROSCOPY PARTICLE - There is provided a method of preparing a surface enhanced Raman spectroscopy (SERS) particle comprising the step of encapsulating a plurality of Raman molecules on the surface of a metallic core with a biocompatible protective shell at an elevated temperature selected to decrease the encapsulation time by more than one-fold relative to an encapsulation performed at 20° C. | 08-01-2013 |
20130224790 | Chalcone Structure Fluorescence Dye For Embryonic Stem Cell Probe - The invention includes a compound represented by the following structural formula: wherein is described herein. The compounds of the invention are useful in staining embryonic stem cells. | 08-29-2013 |
20130244251 | BODIPY Structure Fluorescence Dye for Neural Stem Cell Probe - The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: I or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of neural stem cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can detect and separate neural stem cells without immunostaining, providing a much shorter and more convenient method for detection of neural stem cells. | 09-19-2013 |
20140051109 | NOVEL COMPOUNDS WITH PHOTOLUMINESCENCE PROPERTIES AND APPLICATIONS THEREOF - The present invention relates to compounds of a general formula (I) having photoluminescence properties. The present invention also relates to applications, such as protein imaging tools, involving such compounds. | 02-20-2014 |
20140121129 | Alkylamino BODIPY Dyes As Selective Fluorescent Probes For Proteins And Mouse Embryonic Stem Cells - The present invention discloses a series of alkylamino BODIPY dyes, methods for preparing a library of alkyl-amino BODIPY dyes via solid-phase synthesis, and the use of the alkyl-amino BODIPY dyes as fluorescent sensors for protein detection, cell imaging and cytometry applications, and staining of certain cell line. | 05-01-2014 |
20140359794 | BODIPY STRUCTURE FLUORESCENCE PROBES FOR DIVERSE BIOLOGICAL APPLICATIONS - The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: (I), or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of beta cells, pancreatic islets and microglia cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can also differentiate healthy pancreatic islet cells from diabetic pancreatic islet cells. | 12-04-2014 |