Williams, Essex
Christopher Hugh Williams, Essex GB
Patent application number | Description | Published |
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20090278299 | DOCUMENT COLLATING APPARATUS - An apparatus for collating sheets, the apparatus comprising: a collating station having a collating position limited at its downstream end by a stop member against which the sheets abut whilst they are being collated; means for conveying sheets to the collating position so as to form a collated sheet set comprising a predetermined number of stacked sheets; a collating station eject device for moving the collated sheet set away from the collating position to an exit position; and means for conveying the collated sheet set from the exit position out of the apparatus to a downstream sheet handling device; wherein the collating station eject device comprises at least one movable pawl arranged to push each collated sheet set away from the collating position to the exit position and wherein the apparatus is adapted to collate a second sheet set at least partially overlying the first sheet set. | 11-12-2009 |
20090308715 | CONVEYOR BELT - A method of attaching a pawl to a region of a surface of a conveyor belt comprising pre-stressing the surface region and fixing the pawl to the surface region while it is in the pre-stressed state. | 12-17-2009 |
20090316220 | OPTICAL CODE READER - A system for capturing an image of an optical code located at a region of interest in a document, the system comprising: means for supporting the document; a source of light arranged to illuminate the document; a mount for supporting an imaging device at a position spaced from the document; a trigger for activating the imaging device to capture an image of the region of interest; and means for automatically moving the mount and operating the trigger in dependence upon at least one coordinate identifying the region of interest, the coordinate being contained in a label stored in document parameters. | 12-24-2009 |
20100025920 | VACUUM SHEET FEEDER - A vacuum feeding mechanism for a document handling apparatus, the feeding mechanism comprising: an adjustable pick for separating a stack of documents from a downstream transport system; a rotatable wheel connected to a vacuum port and operable to pull a document by suction from the top of the stack toward the wheel and move the document over the pick to the downstream transport system; the wheel and the pick being separated by a clearance distance; means for determining adjustment coordinates in dependence upon characteristics of a document in the stack; wherein the position of the pick is automatically adjustable in two independent dimensions in dependence upon said adjustment coordinates. | 02-04-2010 |
20100026229 | SERVOMOTOR SPEED CONTROL - A method for controlling a servomotor for driving a movable part of a machine, the method comprising: determining the coordinates of an acceleration and of a deceleration curve for each stage of a cycle of operation to move said part; determining the maximum number of stages required to complete said cycle; initiating the acceleration curve for the first stage of the cycle of operation; and dynamically correcting the cycle of operation, at at least one intermediate point in the cycle, to initiate the deceleration curve appropriate to the stage, at a predetermined decision point, if production line parameters require a change to the operation cycle. | 02-04-2010 |
Gareth Williams, Essex GB
Patent application number | Description | Published |
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20090131327 | NOGO RECEPTOR FUNCTIONAL MOTIFS AND PEPTIDE MIMETICS RELATED THERETO AND METHODS OF USING THE SAME - The present invention provides novel isolated and purified polynucleotides and polypeptides related to functional motifs of the Nogo receptor 1 (NgR1) and use of peptides mimicking these functional motifs as antagonists to NgR1 ligands, e.g., myelin-associated glycoprotein, oligodendrocyte myelin glycoprotein, Nogo-A, Nogo-66, an antibody to Nogo receptor, an antibody to GT1b, an antibody to p75 neurotrophin receptor, and an antibody to Lingo-1, etc. The invention also provides antibodies to the mimetic peptide antagonists. The present invention is further directed to novel therapeutics and therapeutic targets and to methods of screening and assessing test compounds for treatments requiring axonal regeneration, i.e., reversal of the effects of NgR1 ligand binding to the NgR1 (i.e., producing inhibition of axonal growth). The present invention also is directed to novel methods for treating disorders arising from inhibition of axonal growth mediated by the binding of NgR1 ligands to the NgR1. | 05-21-2009 |
Karen Williams, Essex GB
Patent application number | Description | Published |
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20090163534 | Indolizine Derivatives - Compounds of formula (I) are ligands of the CRTH2 receptor and are useful in the treatment of respiratory disease: Formula (I) wherein R | 06-25-2009 |
20100010034 | CRTH2 ANTAGONISTS - The following compounds are CRTH2 antagonists, useful in treatment of respiratory disease: [3-(2,4-dichlorophenylsulfanyl)-6-fluoro-2-methylindolizin-1-yl]acetic acid, [6-fluoro-3-(2-fluoro-4-methanesulfonylphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, [6-fluoro-3-(4-methanesulfonyl-2-trifluoromethylphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, (R)-2-[6-fluoro-3-(4-methanesulfonylphenylsulfanyl)-2-methylindolizin-1-yl]propionic acid, [3-(4-ethanesulfonylphenylsulfanyl)-6-fluoro-2-methylindolizin-1-yl]acetic acid, (S)-2-[6-fluoro-3-(4-methanesulfonylphenylsulfanyl)-2-methylindolizin-1-yl]propionic acid, ethanesulfonylaminobenzenesulfonyl)-6-fluoro-2-methyiindolizin-1-yl]acetic acid, [7-chloro-6-fluoro-3-(4-methanesulfonylphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, [3-(2-chloro-4-methanesulfonylphenylsulfanyl)-7-cyano-2-methylindolizin-1-yl]acetic acid, [6-cyano-3-(4-methanesulfonylbenzyl)-2-methylindolizin-1-yl]acetic acid, [3-(4-chlorobenzyl)-7-cyano-2-methylindolizin-1-yl]acetic acid, [6-cyano-3-(6-fluoroquinolin-2-yl-methyl)-2-methylindolizin-1-yl]acetic acid, [6-fluoro-3-(4-methoxyphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, [7-chloro-6-fluoro-3-(4-methoxyphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, [3-(4-bromophenylsulfanyl)-6-fluoro-2-methylindolizin-1-yl]acetic acid, and [3-(4-cyclopropylsulfamoylphenylsulfanyl)-6-fluoro-2-methylindolizin-1-yl]acetic acid. | 01-14-2010 |
20100216768 | N-SUBSTITUTED AZAINDOLES AND METHODS OF USE - The invention relates to N-substituted azaindolyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to N-substituted azaindolyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. | 08-26-2010 |
20130252941 | PYRAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE - The invention provides compounds of Formula I, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, X, R | 09-26-2013 |