Patent application number | Description | Published |
20100027865 | Method and System for Brain Tumor Segmentation in 3D Magnetic Resonance Images - A method and system for brain tumor segmentation in multi-spectral 3D MRI images is disclosed. A trained probabilistic boosting tree (PBT) classifier is used to determine, for each voxel in a multi-spectral 3D MR image sequence, a probability that the voxel is part of a brain tumor. The brain tumor is then segmented in the multi-spectral 3D MRI image sequence using graph cuts segmentation based on the probabilities determined using the trained PBT classifier and intensities of the voxels in the multi-spectral 3D MR image sequence. | 02-04-2010 |
20100074499 | Method and System for Segmentation of Brain Structures in 3D Magnetic Resonance Images - A method and system for segmenting multiple brain structures in 3D magnetic resonance (MR) images is disclosed. After intensity standardization of a 3D MR image, a meta-structure including center positions of multiple brain structures is detected in the 3D MR image. The brain structures are then individually segmented using marginal space learning (MSL) constrained by the detected meta-structure. | 03-25-2010 |
20110228992 | Method and System for Guiding Catheter Detection in Fluoroscopic Images - A method and system for detecting a guiding catheter in a 2D fluoroscopic image is disclosed. A plurality of guiding catheter centerline segment candidates are detected in the fluoroscopic image. A guiding catheter centerline connecting an input guiding catheter centerline ending point in the fluoroscopic image with an image margin of the fluoroscopic image is detected based on the plurality of guiding catheter centerline segment candidates. | 09-22-2011 |
20110235887 | Computer-Aided Evaluation Of An Image Dataset - A method and system for the diagnosis of 3D images are disclosed, which significantly cuts the time required for the diagnosis. The 3D images are for example an image volume dataset of a magnetic resonance tomography system which is saved in an RIS or PACS system. In at least one embodiment, the diagnostic finding are partially automatically generated, and details of the position, size and change in pathological structures are compared to previous diagnostic findings are generated automatically. As a result of this automation the diagnostic work of radiologists is significantly reduced. | 09-29-2011 |
20120183193 | Method and System for Automatic Detection of Spinal Bone Lesions in 3D Medical Image Data - A method and system for automatic detection and volumetric quantification of bone lesions in 3D medical images, such as 3D computed tomography (CT) volumes, is disclosed. Regions of interest corresponding to bone regions are detected in a 3D medical image. Bone lesions are detected in the regions of interest using a cascade of trained detectors. The cascade of trained detectors automatically detects lesion centers and then estimates lesion size in all three spatial axes. A hierarchical multi-scale approach is used to detect bone lesions using a cascade of detectors on multiple levels of a resolution pyramid of the 3D medical image. | 07-19-2012 |
20130223715 | IMAGE DATA DETERMINATION METHOD, IMAGE PROCESSING WORKSTATION, TARGET OBJECT DETERMINATION DEVICE, IMAGING DEVICE, AND COMPUTER PROGRAM PRODUCT - A second form of image data is determined from a first form of image data of an examination object in a radiological imaging system. A set of a defined plurality of input pixels in the image data of the first form is determined. In addition, a set of target form parameters of a target form model with a defined plurality of target form parameters is prognostically determined by way of a data-driven regression method from the plurality of input pixels. The number of target form parameters is smaller than the number of input pixels. The second form of image data is determined from the set of target form parameters. There is also described a method in radiological imaging for determining the geometric position of a number of target objects in a second form of image data and an image processing workstation for determining a second form of image data from a first form of image data as well as an imaging device. | 08-29-2013 |
20140185888 | METHOD AND SYSTEM FOR LESION CANDIDATE DETECTION - An embodiment of the method is disclosed for non-invasive lesion candidate detection in a patient's body includes generating a number of first medical images of the patient's body. The method further includes identifying lesion-like geometrical regions inside the first medical images of the patient's body by applying image processing methods, whereby the identification is at least partly controlled by a number of patient-specific context features which are not directly extractable from the first medical images. In addition, the method includes selecting a number of the identified lesion-like geometrical regions as lesion candidates. | 07-03-2014 |
20140219548 | Method and System for On-Site Learning of Landmark Detection Models for End User-Specific Diagnostic Medical Image Reading - A method and system for on-line learning of landmark detection models for end-user specific diagnostic image reading is disclosed. A selection of a landmark to be detected in a 3D medical image is received. A current landmark detection result for the selected landmark in the 3D medical image is determined by automatically detecting the selected landmark in the 3D medical image using a stored landmark detection model corresponding to the selected landmark or by receiving a manual annotation of the selected landmark in the 3D medical image. The stored landmark detection model corresponding to the selected landmark is then updated based on the current landmark detection result for the selected landmark in the 3D medical image. The landmark selected in the 3D medical image can be a set of landmarks defining a custom view of the 3D medical image. | 08-07-2014 |
20140254910 | IMAGING DEVICE, ASSIGNMENT SYSTEM AND METHOD FOR ASSIGNMENT OF LOCALIZATION DATA - A method of assigning first localization data of a breast of a patient derived from first image data of the breast, the first image data being the result of a first radiological data acquisition process, to second localization data of the same breast derived from second image data, the second image data being the result of a second radiological data acquisition process, or vice versa. Thereby, the first localization data are assigned to the second localization data by intermediately mapping them into breast model data representing a patient-specific breast shape of the patient and then onto the second image data—or vice versa, thereby deriving assignment data. An assignment system performs the above-described method. | 09-11-2014 |
20150213646 | Method and System for Constructing Personalized Avatars Using a Parameterized Deformable Mesh - A method and apparatus for generating a 3D personalized mesh of a person from a depth camera image for medical imaging scan planning is disclosed. A depth camera image of a subject is converted to a 3D point cloud. A plurality of anatomical landmarks are detected in the 3D point cloud. A 3D avatar mesh is initialized by aligning a template mesh to the 3D point cloud based on the detected anatomical landmarks. A personalized 3D avatar mesh of the subject is generated by optimizing the 3D avatar mesh using a trained parametric deformable model (PDM). The optimization is subject to constraints that take into account clothing worn by the subject and the presence of a table on which the subject in lying. | 07-30-2015 |
Patent application number | Description | Published |
20130280221 | Interleukin 15 as Selectable Marker for Gene Transfer in Lymphocytes - The present invention relates to the use of interleukin-15 (IL-15) as selectable marker for gene transfer, preferably of at least one gene of therapeutic interest, into a mammalian cell or cell line, in particular a human cell or cell line. The present invention furthermore relates to transgenic mammalian cells or cell lines expressing IL-15 as selectable marker and co-expressing at least one protein of interest encoded by at least one gene of interest, which is preferably a protein of therapeutic interest. The present invention is in particular suitable for chimeric antigen receptors (CARs) as the gene or protein of interest and their expression in lymphocytes. The transgenic mammalian cells and cell lines are furthermore suitable for use as a medicament, in particular in the treatment of cancer and in immunotherapy, such as adoptive, target-cell specific immunotherapy. | 10-24-2013 |
20130280285 | CHIMERIC ANTIGEN RECEPTORS WITH AN OPTIMIZED HINGE REGION - The present invention relates to multi-functional proteins which comprise (i) a signal peptide, (ii) a target specific recognition domain, (iii) a linker region, connecting domain (ii) and domain (iv) which comprises a specific modified hinge region of the human CD8 alpha-chain, and (iv) an effector domain. The present invention furthermore relates to nucleic acids encoding the proteins, expression constructs for expressing the protein in a host cell and host cells. The proteins of the invention are chimeric antigen receptors with an optimized linker or hinge region that are suitable for generating target-specific effector cells, for use as a medicament, in particular in the treatment of cancer and in adoptive, target-cell specific immunotherapy. | 10-24-2013 |
20160046729 | CHIMERIC ANTIGEN RECEPTORS WITH AN OPTIMIZED HINGE REGION - The present invention relates to multi-functional proteins which comprise (i) a signal peptide, (ii) a target specific recognition domain, (iii) a linker region, connecting domain (ii) and domain (iv) which comprises a specific modified hinge region of the human CD8 alpha-chain, and (iv) an effector domain. The present invention furthermore relates to nucleic acids encoding the proteins, expression constructs for expressing the protein in a host cell and host cells. The proteins of the invention are chimeric antigen receptors with an optimized linker or hinge region that are suitable for generating target-specific effector cells, for use as a medicament, in particular in the treatment of cancer and in adoptive, target-cell specific immunotherapy. | 02-18-2016 |