Patent application number | Description | Published |
20090042308 | Method for isolating and modifying DNA from blood and body fluids - This invention is related to a method and assay kit for rapidly quantifying global DNA methylation through immobilizing DNA by simple dry-capture on the plastic carrier followed by immunodetection of 5-methylcytosine structure that is the marker of DNA methylation. | 02-12-2009 |
20090326209 | Method for isolating and modifying DNA from blood and body fluids - This invention is related a method for rapidly isolating and modifying DNA from plasma/serum and body fluids. This invention provides a procedure and composition to obtain a high yield of modified DNA for methylation-specific PCR assay by coupling DNA isolation and modification courses. | 12-31-2009 |
20100068720 | Method and kit for detection of early cancer or pre-cancer using blood and body fluids - This invention is related to a method for the detection of early or pre-cancer using DNA isolated from blood and body fluids. This invention provides an improved methylation-based PCR assay, a panel of methylated-based cancer-related gene markers for the detection of general cancer and a panel of unmethylation-based tissue- or cell-specific gene markers for discriminating different type of cancer detected from blood samples. This method couples a sequential cancer-related gene marker detection and tissue or cell-specific gene marker assay and is particularly useful as a simultaneous screening test for following type of cancer: lung, breast, ovarian, colon, stomach, prostatic, pancreatic and liver cancer. | 03-18-2010 |
20120003663 | Method of rapidly quantifying hydroxymethylated DNA - This invention is related to a method for rapidly quantifying hydroxymethylated DNA by binding DNA to a plastic carrier followed by immunodetection of 5-hydroxymethylcytosine or a hydroxymethylcytosine structure that is marker of DNA hydroxymethylation. | 01-05-2012 |
20120107808 | High throughput detection of gene-specific hydroxymethylation - This invention provides a method for the detection of hydroxymethylation patterns in a DNA sample, especially in genetic regions. A test sample containing hydroxymethylated DNA is hybridized to capture oligonucleotides immobilized on a solid phase. The hydroxymethylated DNA in hybrid is detected using an antibody which specifically recognizes hydroxymethylcytosine structure the marker of DNA hydroxymethylation-followed by immuno-signal amplification. The present invention provides a method to detect gene-specific hydroxymethylation in a simple, rapid and high throughput format with high specificity and sensitivity. | 05-03-2012 |
20120122087 | 5-Hydroxymethylcytosine as a biomarker for early detection, treatment and prognostic monitoring of cancer - The present invention is related to the use of 5-hydroxymethylcytosine or a biomolecule having general structure of 5-hydroxymethycytosine as a biomarker for the detection, treatment monitoring, and prognostic prediction of cancer. | 05-17-2012 |
20150099670 | Method of preparing post-bisulfite conversion DNA library - The invention relates to a method of preparing bisulfite-treated DNA library by ligation of adaptors to DNA after bisulfite conversion. The prepared library is suitable for use in sequencing reactions to analyze genome-wide DNA methylation status. | 04-09-2015 |