Weisenberger
Andrew G. Weisenberger, Yorktown, VA US
Patent application number | Description | Published |
---|---|---|
20110089326 | Positron emission tomography and optical tissue imaging - A mobile compact imaging system that combines both of the imaging system of and optical imaging into a single system which can be located in the operating room (OR) and provides faster feedback to determine if a tumor has been fully resected and if there are adequate surgical margins. While final confirmation is obtained from the pathology lab, such a device can reduce the total time necessary for the procedure and the number of iterations required to achieve satisfactory resection of a tumor with good margins. | 04-21-2011 |
Andrew R. Weisenberger, Milwaukie, OR US
Patent application number | Description | Published |
---|---|---|
20140020261 | MOISTURE REDUCTION AND MOLD AND MOISTURE DAMAGE PREVENTATIVE SYSTEM AND METHOD IN CONSTRUCTION - A moisture removal system and method employing air movers, dehumidifiers, heaters and attendant methods for reducing moisture in a construction project. The method and system include operating moisture removal equipment and testing moisture content levels sufficient to reduce the moisture content levels to a desired threshold to reduce the likelihood of mold growing or moisture damage in the construction after it is completed. | 01-23-2014 |
Daniel J. Weisenberger, Los Angeles, CA US
Patent application number | Description | Published |
---|---|---|
20130065228 | GENOME-SCALE ANALYSIS OF ABERRANT DNA METHYLATION IN COLORECTAL CANCER - Particular aspects provide methods and compositions (e.g., gene marker panels) having substantial utility for at least one of diagnosis, identification and classification of colorectal cancer (CRC) (e.g., tumors) relating to distinctive DNA methylation-based subgroups of CRC including CpG island methylator phenotype (CIMP) groups (e.g., CIMP-H and CIMP-L) and non-CIMP groups. Exemplary marker panels include: B3GAT2, FOXL2, KCNK13, RAB31 and SLIT1 (CIMP marker panel); and FAM78A, FSTL1, KCNC1, MYOCD, and SLC6A4 (CIMP-H marker panel). Further aspects relate to genetic mutations, and other epigenetic markers relating to said CRC subgroups that can be used in combination with the gene marker panels for at least one of diagnosis, identification and classification of colorectal cancer (CRC) (e.g., tumors) relating to distinctive CIMP and non-CIMP groups. | 03-14-2013 |
Daniel J. Weisenberger, Playa Del Rey, CA US
Patent application number | Description | Published |
---|---|---|
20080254474 | DNA METHYLATION ANALYSIS BY DIGITAL BISULFITE GENOMIC SEQUENCING AND DIGITAL METHYLIGHT - Provided are novel sensitive methylation assays referred to herein as Digital MethyLight, comprising stochastically distributing and compartmentalizing bisulfite-treated genomic DNA over multiple PCR reaction wells for detection of individually methylated DNA molecules in a large background of unmethylated DNA. Digital Bisulfite Genomic DNA Sequencing methods are also provided for high-resolution DNA methylation information without subcloning. Background signal and PCR contaminants are diluted, while the ratio of primer to methylated template DNA is kept high. Preferably, biological fluid (e.g., urine, blood-based (e.g., plasma and/or serum)) samples are analyzed for cancer diagnosis, prognosis and surveillance. Multiplexed PCR formats may be implemented to enhance when using small DNA amounts. Compositions and methods for diagnosis and/or prognosis of breast cancer, comprising the use of FOXE1, CLDN5 and/or RUNX3 gene markers are also provided (SEQ ID NOS: 17, 16 and 18, respectively for respective CpG island sequences), and in preferred embodiments plasma or serum samples are used. | 10-16-2008 |
20090123915 | HIGH THROUGHPUT METHODS COMPRISING ANALYSIS OF REPETITIVE ELEMENT DNA METHYLATION - Preferred aspects provide novel high-throughput, sensitive methods (e.g., real-time PCR-based (MethyLight™) reactions) for detection and/or measurement of global genomic 5-methylcytosine content, based on measurement of DNA methylation of Alu, LINE-1 repetitive sequences, and the chromosome 1 centromeric satellite alpha and juxtacentromeric satellite 2 repeat sequences. Additional aspects provide sensitive methods for determining the amount of a DNA (e.g., in formalin-fixed, paraffin-embedded tissues). Combined (mean) use of Alu and Sat2 repeat methylation measurements provides for a surprisingly close correlation with global genomic 5-methylcytosine content measurements obtained by HPLC. Methylation of Alu repeats was determined to be closely associated with HPLC-based global methylation levels, as was methylation of satellite 2 and LINE-1 global genomic 5-methylcytosine content. The assays provide surrogate markers for global genomic 5-methylcytosine content analyses, and have substantial utility for high-throughput and population-based studies (e.g., genetic and dietary influences on global DNA methylation, folate deficiency, MTHFR gene polymorphisms, etc). | 05-14-2009 |
20120219946 | DNA METHYLATION MARKERS ASSOCIATED WITH THE CPG ISLAND METHYLATOR PHENOTYPE (CIMP) IN HUMAN COLORECTAL CANCER - Particular aspects confirm the existence of a CpG island methylator phenotype (CIMP) in colorectal cancer, and provide novel validated DNA methylation markers associated with CIMP. Additional aspects provide novel methods and compositions for: determining CIMP status in colorectal cancers, determining the relationship between CIMP status and other molecular features of the cancers (e.g., BRAF mutation, KRAS mutation and MSI status); determining the relationship between CIMP status and other variables (e.g., age, sex, tumor location, family history, race, country of origin, tumor characteristics (including, tumor type, tumor grade, invasive margin characteristics, lymphocyte infiltration characteristics, direct spread, lymph node spread, venous spread and type of residual adjacent polyp, if present)); and determining, between subgroups defined by CIMP status and BRAF mutations, effects of selected risk factors (e.g., body mass index, smoking history, alcohol intake, dietary folate intake, folate metabolic enzyme polymorphisms and history of hormonal use). | 08-30-2012 |
Fabian Weisenberger, Emmendingen DE
Patent application number | Description | Published |
---|---|---|
20100219326 | Optoelectronic sensor with alignment light transmitter - An optoelectronic sensor ( | 09-02-2010 |
Mathew C. Weisenberger, Georgetown, KY US
Patent application number | Description | Published |
---|---|---|
20120231259 | APPARATUS AND METHOD FOR HARVESTING CARBON NANOTUBE ARRAYS - An apparatus is provided for harvesting a carbon nanotube array from a substrate. The apparatus includes a peeler that peels the carbon nanotube array from the substrate and a support that receives the carbon nanotube array peeled from the substrate. In addition the apparatus includes a drawing device that simultaneously draws the carbon nanotube array from the substrate onto the support as the carbon nanotube array is peeled from the substrate. The peeler and drawing device are synchronized in operation so that as a given length of carbon nanotube array is peeled from the substrate, that same given length of carbon nanotube array is drawn onto the support. | 09-13-2012 |
Matthew Weisenberger, Georgetown, KY US
Patent application number | Description | Published |
---|---|---|
20140106167 | METHOD FOR HYBRID DRY-JET GEL SPINNING AND FIBER PRODUCED BY THAT METHOD - A method of spinning a polyacrylonitrile PAN-based precursor fiber comprises extruding a spinning solution of ultra-high molecular weight polyacrylonitrile polymer through a multi-filament spinnerette where the solution has a viscosity of between about 100 and about 300 Pa-sec (at a shear rate of 1 l/sec) at a dope extrusion temperature of between about 20° C. and about 26° C., producing a fiber having a diameter of between about 4 and about 10 micron, a tensile strength of between about 500 and about 1100 MPa, and an elastic modulus between about 13 and about 18 GPa. | 04-17-2014 |
Matthew C. Weisenberger, Georgetown, KY US
Patent application number | Description | Published |
---|---|---|
20090266477 | LIGHTWEIGHT THERMAL MANAGEMENT MATERIAL FOR ENHANCEMENT OF THROUGH-THICKNESS THERMAL CONDUCTIVITY - A flexible sheet of aligned carbon nanotubes includes an array of aligned nanotubes held in a polymer matrix material. The carbon nanotubes have an average length of between about 50 microns and about 500 microns. The polymer matrix has an average thickness of between about 10 microns and about 500 microns. The flexible sheet has a density of about 0.2 to about 1.0 g/cc and includes between about 98 to about 60 weight percent aligned carbon nanotubes and between about 2 and about 40 weight percent polymer. A tape of aligned carbon nanotubes, a method for producing a tape of aligned carbon nanotubes, a method of producing the flexible aligned carbon nanotube sheet material and a method of increasing unidirectional heat conduction from a work piece are also disclosed. | 10-29-2009 |
20120060826 | THERMAL INTERFACE MATERIAL - A flexible sheet of aligned carbon nanotubes includes an array of aligned nanotubes in a free standing film form not adhered to the synthesis substrate, with a matrix infiltrated interstitially into the nanotube array with access to the nanotube tips from both the top and bottom. That is, the infiltrant is purposely limited from over-filling or coating one or both exterior top and/or bottom surfaces of the array, blocking access to the tips. A typical matrix is a polymer material. | 03-15-2012 |
Matthew Collins Weisenberger, Georgetown, KY US
Patent application number | Description | Published |
---|---|---|
20140356613 | CARBON NANOTUBE STUDDED CARBON FIBER TOW AND MATRIX PREPREG - A carbon nanotube studded carbon fiber tow and matrix prepreg includes a body comprising a tow of surface fibers and interior bulk fibers. The surface fibers are studded with carbon nanotubes and the carbon fibers are infiltrated with a matrix material. | 12-04-2014 |
Pamela J. Weisenberger, Racine, WI US
Patent application number | Description | Published |
---|---|---|
20130195384 | Storage Bag With Visually Distinct Features Providing The Bag With An Asymmetric Appearance - A storage bag is provided with visually distinct features that facilitate opening and closing of the bag. The visually distinct features result in the bag having an asymmetric appearance about one or more imaginary lines along the bag. The visually distinct features and resulting asymmetries provide a visual cue for a user as to how the bag should be grasped when being opened. The visually distinct features, as well as other features of the bag, may also facilitate manufacturing of the bag. | 08-01-2013 |
20140093192 | Storage Bag With Textured Area On Lips To Facilitate Closing Process - A storage bag has first and second closure profiles that include interlocking members configured to seal an opening of the bag. A textured area is provided on the first closure profile adjacent to the interlocking member and adjacent to an end of the first closure profile. The textured area provides a visual cue to indicate that the process of sealing the interlocking members should begin at the end of the first closure profile and move towards a center of the bag. | 04-03-2014 |
20140093193 | Storage Bag With Colored Lips - A storage bag has a first closure profile attached to a first side surface, with the first closure profile forming a lip between an interlocking member and an edge of the first closure profile. The bag also includes a second closure profile attached to the second side surface, with the second closure profile forming a lip between an interlocking member and an edge of the second closure profile. The lips of the first and second closure profiles are visually distinct colors or different shades of a color in order to aid the user in locating the lips. | 04-03-2014 |
20140093194 | Storage Bag With Lips Shaped To Facilitate Unsealing Of The Bag - A storage bag is provided with lips that are shaped to facilitate unsealing of the bag. The lips include a visual cue that indicates to a user where the lips should be grasp during the unsealing operation. The visual cue may include any of a notch, a specific formation of the lips, and a color of the lips. When grasping the lips in the area of the lips indicated by the visual cue, the user can perform a rolling motion that greatly facilitates opening of the bag. | 04-03-2014 |
20140093195 | Storage Bag With Features That Facilitate Sealing And Unsealing Of The Bag - A storage bag is provide with features that facilitate unsealing an opening of the bag, including shaped lips and visual cues for areas that the lips that should be grasped during the unsealing process. The visual cue may include relative coloring of portions of the lips of the bag. The storage bag also includes features that facilitate sealing the opening of the bag, including textured areas and dimples. Such features may provide visual cues, tactile feedback and/or audio feedback in order to facilitate the sealing process. | 04-03-2014 |
Robert A. Weisenberger, West Linn, OR US
Patent application number | Description | Published |
---|---|---|
20140020261 | MOISTURE REDUCTION AND MOLD AND MOISTURE DAMAGE PREVENTATIVE SYSTEM AND METHOD IN CONSTRUCTION - A moisture removal system and method employing air movers, dehumidifiers, heaters and attendant methods for reducing moisture in a construction project. The method and system include operating moisture removal equipment and testing moisture content levels sufficient to reduce the moisture content levels to a desired threshold to reduce the likelihood of mold growing or moisture damage in the construction after it is completed. | 01-23-2014 |