Patent application number | Description | Published |
20090142372 | Therapeutic composition for use in the prevention and treatment of bone metastases - The invention is relates to drugs on the basis of antibodies against non-cellular bone matrix proteins, especially BSP, for use in the prevention and treatment of bone metastases. According to the invention, the antibodies are induced in the patient by recombinantly expressing antigenic determinants of bone matrix proteins in | 06-04-2009 |
20090220517 | METHOD FOR PRODUCING EPITOMERS AND THEIR USES ON CARRIER MICROORGANISMS - The present invention relates to a method for producing carrier microorganisms, in particular bacteria, which, through targeted genetic manipulation, carry epitopes or epitomers, respectively, on their surfaces. Epitomers are antigenically effective epitopes that can be found in the polypeptide chain in multiple identical copies, and which, when expressed on the surface of the bacteria, can be used for immunization with particular success. A further aspect relates to correspondingly produced bacteria and their uses as vaccines, in particular in cancer therapy. | 09-03-2009 |
20110020845 | METHOD FOR THE DETECTION AND IDENTIFICATION OF A VARIANT C. DIFFICILE STRAIN IN A SAMPLE - The method for detecting and identifying a variant | 01-27-2011 |
20130045199 | Antibody Preparations - An antibody preparation suitable for intravenous administration in humans includes IgG, IgA and at least 5% IgM antibodies by weight of the total amount of antibodies. The preparation is prepared from human plasma, has specific complement activating activity, and, in an in vitro assay with human serum suitable to determine the ability of the antibody preparation to activate complement unspecifically, the antibody preparation generates substantially no C5 | 02-21-2013 |
20150064170 | Antibody Preparations - An antibody preparation suitable for intravenous administration in humans includes IgG, IgA and at least 5% IgM antibodies by weight of the total amount of antibodies. The preparation is prepared from human plasma, has specific complement activating activity, and, in an in vitro assay with human serum suitable to determine the ability of the antibody preparation to activate complement unspecifically, the antibody preparation generates substantially no C5a and/or substantially no C3a. The antibody preparation can have medical uses. | 03-05-2015 |
Patent application number | Description | Published |
20100263642 | INTAKE MODULE WITH INTEGRATED EXHAUST GAS RECIRCULATION - An integrated exhaust gas recirculation intake module comprises: an intake system including a fresh air channel; and a coupling device, wherein the coupling device is configured to receive an exhaust gas recirculation valve, wherein the coupling device is configured to connect an exhaust gas channel with a fresh gas channel, and wherein the exhaust gas channel is connected with the coupling device such that a heat transfer is hindered. | 10-21-2010 |
20140116371 | COMPONENT AND ASSOCIATED PRODUCTION METHOD - A method for producing an intake module may include providing a housing and at least one intercooler arranged therein; forming at least two housing parts via injection moulding from plastic; inserting at least one intercooler into at least one of the housing parts; wherein the housing parts, with at least one intercooler inserted therein, are welded together to form the housing; and wherein the intercooler has contact points to at least two of the housing parts. | 05-01-2014 |
20140216385 | FRESH AIR SUPPLY DEVICE OF AN INTERNATIONAL COMBUSTION ENGINE - A fresh air supply device for an internal combustion engine may include a suction module for conducting supercharged fresh air and a charge air cooler arranged in the suction module for cooling the supercharged fresh air. The suction module includes a housing with a charge air inlet for uncooled charge air and a charge air outlet for cooled charge air. The housing has a cooler shell, which may include the charge air inlet containing the charge air cooler and an assembly opening. With respect to a flow direction of the charge air the assembly opening may be arranged downstream of the charge air cooler and through which the charge air cooler is inserted into the cooler shell. The housing has a connecting shell, which includes the charge air outlet and which in the region of the assembly opening is attached to the cooler shell in an air-tight manner. | 08-07-2014 |
20140246186 | HEAT EXCHANGER ASSEMBLY - A heat exchanger assembly may include an intercooler and a housing which encloses said intercooler. The housing may be part of a charge air line. The housing may include a charge air inlet, a charge air outlet and an opening through which the intercooler can be inserted into the housing from one side. The housing may also include a recess on the side opposite the opening, into which recess the intercooler engages. The heat exchanger assembly may include an elastic seal arranged in the region of the recess between the intercooler and the housing. The seal may be configured to at least one of bridge the deformation of the housing occurring during pressure pulsations, bridge relative movements between the intercooler and the housing, and tightly connect the intercooler to the housing in all operating states preventing an undesirable bypass flow. | 09-04-2014 |
20150075750 | CHARGE-AIR COOLING DEVICE - A charge-air cooling device for a fresh air system of an internal combustion engine may include a housing which contains a charge-air duct and a heat exchanger having an internal coolant path and an external charge-air path. The housing may have a mounting opening, through which the heat exchanger is pushed into the housing in a longitudinal direction of the heat exchanger such that, in a pushed-in state, the charge-air duct leads through the charge-air path. The housing may include at least one wall in a receiving region which receives the heat exchanger. The wall may be elastic and, by the heat exchanger being pushed into the receiving region, the wall may be transferred from a relaxed state when the heat exchanger has not been pushed into the receiving region, into a stressed state when the heat exchanger has been pushed into the receiving region. | 03-19-2015 |
20150338167 | HEAT EXCHANGER - A heat exchanger for transferring heat between a gaseous first fluid and a liquid second fluid may include a plurality of hollow pipes extending transversely through a first fluid path for conducting the first fluid. The plurality of pipes may be coupled externally to a plurality of cooling fins arranged in the first fluid path. The plurality of pipes may internally define a second fluid path for conducting the second fluid. The plurality of pipes and the plurality of cooling fins may be arranged stacked on one another in a stacking direction to define a cooler block. The cooler block may include two side parts extending along two outer sides of the cooler block facing away from one another in the stacking direction. At least one tension rod may fixedly connect the two side parts and be configured to transmit a tensile force in the stacking direction. | 11-26-2015 |
Patent application number | Description | Published |
20120185827 | CUSTOM CODE LIFECYCLE MANAGEMENT - A method is provided to manage program code that runs in a computer system comprising: producing a management information structure that identifies a managed system within the computer system; producing a master object definition information structure that provides a mapping between master objects and corresponding managed code objects that run in the computer system; and requesting extraction of information from the managed system identified by the master information structure that relates to managed code objects that the object definition information structure maps to master objects. | 07-19-2012 |
20130055235 | CUSTOM CODE INNOVATION MANAGEMENT - A method to manage program code that runs in a computer system comprising: producing a transfer template information definition structure in a computer readable storage device that includes a provider code attribute a similarity measure attribute and at least one results attribute; producing a transfer instance of the transfer template information definition structure that associates a provider code object identified as corresponding to the respective managed code object with the provider object code attribute and that associates the determined measure of similarity with the similarity measure attribute; using the transfer instance to obtain results information from a provider system that includes information about the provider code object. | 02-28-2013 |
20130167114 | CODE SCORING - Methods and apparatus, including computer program products, are provided for code scoring. In one aspect, there is provided a computer-implemented method. The method may include receiving metadata including information representative of at least one custom code module used in a business system; receiving at least one rule from a rules template; and calculating, based on the received metadata and the received at least one rule, a score representative of whether the at least one custom code module is maintained. Related apparatus, systems, methods, and articles are also described. | 06-27-2013 |
20140081712 | SUPPORTABILITY PERFORMANCE INDEX - Methods and apparatus, including computer program products, are provided for determining a supportability index. In one aspect, there is provided a computer-implemented method. The method may include receiving metadata including information representative of one or more modules used by a manager providing lifecycle support to a business system; receiving at least one rule from a rules template, the at least one rule representative of a process to perform a calculation to determine a score; and calculating, based on the received metadata and the received at least one rule, the score representative of an amount of lifecycle support the manager including the one or more modules provide to the business system. Related apparatus, systems, methods, and articles are also described. | 03-20-2014 |
Patent application number | Description | Published |
20080313581 | INDEPENDENT MIGRATION OF HIERARCHICAL DESIGNS WITH METHODS OF FINDING AND FIXING OPENS DURING MIGRATION - Methods of independently migrating a hierarchical design are disclosed. A method for migrating a macro in an integrated circuit comprises: determining an interface strategy between a base cell in the macro and the macro, the base cell including an interface element involved in the interface strategy; migrating the base cell independently with respect to the macro based on the interface strategy; initially scaling the macro; swapping the migrated base cell into the macro; and legalizing content of the initially scaled macro. | 12-18-2008 |
20090112963 | METHOD TO PERFORM A SUBTRACTION OF TWO OPERANDS IN A BINARY ARITHMETIC UNIT PLUS ARITHMETIC UNIT TO PERFORM SUCH A METHOD - A method, circuit apparatus, and a design structure on which the circuit resides, is provided to perform a subtraction of two operands in a binary arithmetic unit by subdividing two operands into groups of equal numbers of bits, generating, by appropriate arithmetic operations, pairs of intermediate results for the particular groups of bits of the two operands comprising the same bit positions, respectively. A first intermediate result of each pair of intermediate results is generated under the assumption of a carry-in of ‘0’ and a second intermediate result of each pair of intermediate results is generated under the assumption of a carry-in of ‘1’. The correct intermediate result of each particular pair of intermediate results from each group of bits is selected, and the result of the subtraction of the two operands is generated by an appropriate merging of the selected correct intermediate results. | 04-30-2009 |
20130074025 | POST TIMING LAYOUT MODIFICATION FOR PERFORMANCE - A mechanism is provided for post timing layout modification for performance. The mechanism selectively applies layout modification based on timing analysis at the path level. The mechanism applies stress only to transistors that are in a setup critical path without applying stress to transistors in hold critical paths. The mechanism may use a method to apply stress to improve performance of a transistor in a setup critical path, as long as the stress does not also improve performance of a neighboring transistor in a hold critical path. In some instances, the mechanism may apply stress to improve performance of a transistor in a setup critical path while simultaneously degrading performance of a transistor in a hold critical path. | 03-21-2013 |