Patent application number | Description | Published |
20090143386 | Human adam-10 inhibitors - The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom. | 06-04-2009 |
20090215803 | Pyrimidinones as Casein Kinase II (CK2) Modulators - A compound having Formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R | 08-27-2009 |
20100298290 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture - The invention is directed to Compounds of Formula I: | 11-25-2010 |
20110021525 | P70S6 Kinase Modulators and Method of Use - The invention provides compounds and methods for inhibition of kinases, more specifically p70S6 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. | 01-27-2011 |
20130144056 | Human Adam-10 Inhibitors - The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. | 06-06-2013 |
20140206865 | Human Adam-10 Inhibitors - The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. | 07-24-2014 |
Patent application number | Description | Published |
20080263066 | DATA MANAGEMENT SYSTEM, DATA REGISTRATION DEVICE, DATA RETRIEVAL DEVICE, DATA MANAGEMENT METHOD AND PROGRAM - A technology is provided of obtaining a retrieval result suited for a user' desire in a case of retrieving data expressed by the code system such as UNICODE in which techniques of expressing one character exist in plural. With registration data including a composing character or a compatibility character, a key item being included in the registration data, which should be made retrievable with a normalized retrieval key as well, is normalized, and is registered into a drawer, and the key item being included in the registration data, which should be made unretrievable, is registered into the drawer as it stands. At the time of retrieving data, in a case of desiring to retrieve data alone of which the key item coincides with that of the retrieval key, a user gives an designation for performing no normalization process to an option designator, and thereafter, inputs the retrieval key, and in a case of desiring to retrieve data as well of which the key item coincides with that of the normalized retrieval key, a user gives a designation for performing a normalization process, and thereafter, inputs the retrieval key. A retriever employs the retrieval key or the normalized retrieval key to retrieve data. | 10-23-2008 |