Truppo
Matthew D. Truppo, Bradley Beach, NJ US
Patent application number | Description | Published |
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20130149751 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS - The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates. | 06-13-2013 |
20140106413 | IMMOBILIZED TRANSAMINASES AND PROCESS FOR MAKING AND USING IMMOBILIZED TRANSAMINASE - The invention is directed to immobilized transaminases and methods of making and using them. | 04-17-2014 |
Matthew D. Truppo, Ocean Township, NJ US
Patent application number | Description | Published |
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20130164794 | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXAMINE - The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker. | 06-27-2013 |
Matthew D. Truppo, Rahway, NJ US
Patent application number | Description | Published |
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20150259284 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS - The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: | 09-17-2015 |