Patent application number | Description | Published |
20130034523 | USE OF SDF-1 TO MITIGATE SCAR FORMATION - The subject matter provided herein relates to method for inhibiting or mitigating scar formation in a wound of the skin, by increasing the concentration of SDF-1 in, or proximate to, the wound. As described herein SDF-1 protein or an SDF-1 expression vector can be administered to a wound or the area proximate a wound by providing a therapeutically effective amount of SDF-1 protein or an SDF-1 expression vector. | 02-07-2013 |
20130053961 | REINFORCED TISSUE GRAFT - A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch that has a peripheral surface and at least one fiber stitched in a reinforcing pattern to mitigate tearing of the graft, improve the fixation retention of the graft, and/or limit cyclic stretching of the graft and substantially maintain these properties following partial enzymatic degradation of the graft while it remodels. The at least one fiber includes at least one free end that extends beyond the peripheral surface of the extracellular matrix for securing the patch to a host tissue. | 02-28-2013 |
20130060227 | APPARATUS AND METHOD FOR DELIVERING A THERAPEUTIC AGENT TO OCULAR TISSUE - A method is provided for delivering at least one therapeutic agent to an ocular tissue of a subject. The method includes providing an apparatus including at least one electrode, a medicament layer including at least one therapeutic agent, an electrical signal source, and logic configured to control the electrical signal source. The at least one electrode has oppositely disposed first and second dome-shaped major surfaces. The medicament layer is disposed on at least a portion of the second major surface. The electrical signal source is electrically connected to the at least one electrode. At least one portion of the first major surface is placed into contact with the ocular tissue so that the at least one portion substantially conforms to the contour of the ocular tissue. The electrical signal source provides a signal having certain characteristics to motivate the at least one therapeutic agent into the ocular tissue. | 03-07-2013 |
20130079870 | ENDOLUMINAL PROSTHESIS WITH STEERABLE BRANCH - An endoluminal prosthesis may include a tubular main graft body including a sidewall and proximal and distal ends. A first stent may be positioned near the proximal end of the main graft body. A second stent may be positioned adjacent to and distal of the first stent. An opening in the sidewall may be positioned longitudinally between a peak of the first stent and a valley of the second stent. A tubular branch may be disposed in the opening. The branch may include first and second end openings. The branch may be flexibly orientable between a retrograde configuration in which the first end opening is oriented toward the distal end and the second end opening is oriented toward the proximal end and an antegrade configuration in which the first end opening is oriented toward the proximal end and the second end opening is oriented toward the distal end. | 03-28-2013 |
20130096891 | ESTIMATION OF NEURAL RESPONSE FOR OPTICAL STIMULATION - This disclosure relates generally to systems and methods for estimating a volume of tissue directly influenced (VTDI) by optogenetic stimulation. The systems and methods can also enable a user to quantitatively predict the spread of stimulation (e.g., action potential) resulting from optical stimulation in a patient's tissue. | 04-18-2013 |
20130102536 | COMPOSITIONS AND METHODS FOR MODULATING TOLL-LIKE RECEPTOR 2 ACTIVATION - A method of promoting hair growth of a subject includes administering to follicle cells of the subject a therapeutically effective amount of a TLR2 agonist that promotes TLR2 activation and hair growth of the subject. | 04-25-2013 |
20130116799 | REINFORCED TISSUE GRAFT - A biocompatible tissue graft includes a first layer of a bioremodelable collageneous material, a second layer of biocompatible synthetic or natural remodelable or substantially remodelable material attached to the first layer; and at least one fiber that is stitched in a reinforcing pattern in the first layer and/or second layer to mitigate tearing and/or improve fixation retention of the graft, and substantially maintain the improved properties while one or more of the layers is remodeling. | 05-09-2013 |
20130123631 | System and Method of Characterizing Vascular Tissue - A system and method is provided for using backscattered data and known parameters to characterize vascular tissue. IVUS data is transmitted to a computing device and used to create an IVUS image. The blood vessel is then cross-sectioned and used to identify its tissue type and to create a corresponding image (i.e., histology image). A region of interest (ROI) is then identified on the histology image. The computing device identifies a corresponding region on the IVUS image. After the corresponding region is identified, the IVUS data that corresponds to this region is identified. Signal processing is then performed and at least one parameter is identified. The identified parameter and the tissue type is stored in a database. In another embodiment of the present invention, the characterization application is adapted to use the parameters stored in the database to identify a tissue type or a characterization thereof. | 05-16-2013 |
20130132117 | GRAPHICAL TOOL FOR MANAGING A LONGITUDINAL PATIENT EPISODE - Systems and methods are disclosed for graphical-based management and documentation of longitudinal care episodes. As one example, a system to manage a longitudinal care episode for a patient can include a patient data aggregator, executable by a processor, to provide context data for the patient, at least a portion of the context data including patient data associated with multiple phases of the longitudinal care episode. A tool manager can translate user interactions with an associated graphical user interface (GUI) into corresponding discrete concepts. The corresponding discrete concepts can be stored in memory as part of longitudinal episode data for the patient, the longitudinal episode data being generated based on the context data and in response to user interactions with the GUI to facilitate documentation and management of the longitudinal care episode. | 05-23-2013 |
20130138400 | METHOD FOR MODELING BIOMECHANICAL PROPERTIES OF AN EYE - Systems and methods are provided for predicting the results of a therapeutic intervention to an eye. An imaging system is configured to provide image data representing at least a portion of the eye of the patient. An input device is configured to permit a user to design a proposed therapeutic intervention for the eye of the patient. A finite element modeling component is configured to generate a finite element model representing the condition of the eye of the patient after the proposed therapeutic intervention according to the image data, the proposed therapeutic intervention, and at least one biomechanical property of tissue comprising the eye. The generated model is constructed as to have no a priori restraints on the motion of the corneal limbus. A display is configured to display the generated model to the user. | 05-30-2013 |
20130144270 | METHODS AND DEVICES TO CLEAR OBSTRUCTIONS FROM MEDICAL TUBES - A device for clearing obstructions from a medical tube, such as a chest tube, is disclosed in various embodiments. The device features a clearance member in the form of a loop. The loop desirably has a diameter that substantially corresponds to the inner diameter of the medical tube. Also desirably, the loop presents a substantially unobstructed pathway therethrough for the flow of material from a location in the medical tube distal to the loop to a location in the medical tube proximal to the loop regardless whether the clearance member is being translated or is at rest in the medical tube. Methods of utilizing such a device are also disclosed. | 06-06-2013 |
20130172898 | APPARATUS AND METHOD FOR DICTATING AT LEAST ONE OF A DESIRED LOCATION AND A DESIRED TRAJECTORY FOR ASSOCIATION OF A LANDMARK WITH A PATIENT TISSUE - An apparatus for transferring location and/or trajectory information from a reference surface to a patient tissue surface for guiding placement of a landmark includes a landmark guiding structure. At least two locating feet are provided, each being laterally spaced from, and indirectly connected to, the landmark guiding structure. A holdaway structure is connected to each locating foot and to the landmark guiding structure. The landmark guiding structure is placed in desired location and/or a desired trajectory with respect to the reference surface. Each locating foot is adjusted into guiding contact with a particular portion of the reference surface. Each locating foot is maintained in the guiding contact position, and the apparatus is placed with each locating foot in guiding contact with a particular portion of the patient tissue surface. A method of transferring location and/or trajectory information from a reference surface to a patient tissue surface is also disclosed. | 07-04-2013 |
20130172953 | METHODS AND SYSTEMS FOR TREATING ACUTE HEART FAILURE BY NEUROMODULATION - Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation. | 07-04-2013 |
20130173306 | STORING STRUCTURED AND UNSTRUCTURED CLINICAL INFORMATION FOR INFORMATION RETRIEVAL - A computer-implemented method can include acquiring data from at least one data source, the acquired data including health data for a patient. The acquired data can be transformed into episode model data according to a context-specific data model and the episode model data can be stored in a database. The method also includes generating at least one inverted index document for at least a portion of an episode for the patient based on the episode model data. | 07-04-2013 |
Patent application number | Description | Published |
20130066347 | METHOD AND APPARATUS FOR INCREASING BLOOD FLOW THROUGH AN OBSTRUCTED BLOOD VESSEL - A method of increasing blood flow through an obstructed blood vessel includes providing an expandable member substantially made of a mesh having a plurality of interstices. The expandable member is inserted into the blood vessel, positioned within the blood vessel with the proximal member end upstream of the distal member end and the member body located radially adjacent at least a portion of an obstruction, and expanded to bring at least a portion of the member body into contact with the obstruction. An outward radial force is exerted on the obstruction to dislodge at least one fragment from the obstruction and to enhance blood flow through the blood vessel past the obstruction. The at least one fragment is passed through at least one interstice of the member body in the radial direction, and is selectively retained within the expandable member. | 03-14-2013 |
20130066348 | METHOD AND APPARATUS FOR INCREASING BLOOD FLOW THROUGH AN OBSTRUCTED BLOOD VESSEL - A method of increasing blood flow through an obstructed blood vessel includes providing an expandable member substantially made of a mesh having a plurality of interstices. The expandable member is inserted into the blood vessel, positioned within the blood vessel with the proximal member end upstream of the distal member end and the member body located radially adjacent at least a portion of an obstruction, and expanded to bring at least a portion of the member body into contact with the obstruction. An outward radial force is exerted on the obstruction to dislodge at least one fragment from the obstruction and to enhance blood flow through the blood vessel past the obstruction. The at least one fragment is passed through at least one interstice of the member body in the radial direction, and is selectively retained within the expandable member. | 03-14-2013 |
20130131703 | METHOD AND APPARATUS FOR INCREASING BLOOD FLOW THROUGH AN OBSTRUCTED BLOOD VESSEL - A method of increasing blood flow through an obstructed blood vessel includes providing an expandable member substantially made of a mesh having a plurality of interstices. The expandable member is inserted into the blood vessel, positioned within the blood vessel with the proximal member end upstream of the distal member end and the member body located radially adjacent at least a portion of an obstruction, and expanded to bring at least a portion of the member body into contact with the obstruction. An outward radial force is exerted on the obstruction to dislodge at least one fragment from the obstruction and to enhance blood flow through the blood vessel past the obstruction. The at least one fragment is passed through at least one interstice of the member body in the radial direction, and is selectively retained within the expandable member. | 05-23-2013 |
20130165871 | METHOD AND APPARATUS FOR INCREASING BLOOD FLOW THROUGH AN OBSTRUCTED BLOOD VESSEL - A method of increasing blood flow through an obstructed blood vessel includes providing an expandable member substantially made of a mesh having a plurality of interstices. The expandable member is inserted into the blood vessel, positioned within the blood vessel with the proximal member end upstream of the distal member end and the member body located radially adjacent at least a portion of an obstruction, and expanded to bring at least a portion of the member body into contact with the obstruction. An outward radial force is exerted on the obstruction to dislodge at least one fragment from the obstruction and to enhance blood flow through the blood vessel past the obstruction. The at least one fragment is passed through at least one interstice of the member body in the radial direction, and is selectively retained within the expandable member. | 06-27-2013 |