Patent application number | Description | Published |
20100023038 | DEVICES AND METHODS FOR DISRUPTION AND REMOVAL OF LUMINAL OCCLUSIONS - The subject invention pertains to an elastic sheath, device, and methods for disrupting and/or removing occlusive material from lumens, particularly biological lumens, such as the vasculature, ureter, urethra, fallopian tubes, bile duct, intestines, and the like. The subject invention provides for effective disruption and removal of occlusive material, such as a thrombus, from the body lumen with minimal risk of injury to the lumen wall. Advantageously, the invention can be used to achieve a high degree of removal while minimizing the amount of occlusive material that is released into the body lumen. The subject invention further pertains to methods for disrupting and removing occlusive material from a biological lumen. In another aspect, the present invention concerns a device useful as an in vitro model of luminal occlusion and methods for using the device to test the efficacy of devices and methods for treating luminal occlusions. | 01-28-2010 |
20100254911 | MULTIMODAL NANOPARTICLES FOR NON-INVASIVE BIO-IMAGING - Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging. | 10-07-2010 |
20110021745 | ULTRA-SMALL CHITOSAN NANOPARTICLES USEFUL AS BIOIMAGING AGENTS AND METHODS OF MAKING SAME - A method of making ultra-small chitosan nanoparticles having a size range of approximately 10-20 nm, includes preparing a first microemulsion containing effective amounts of cyclohexane, n-hexanol, chitosan polymer and a nonionic surfactant. A second microemulsion is prepared containing effective amounts of cyclohexane, n-hexanol, tartaric acid, EDC, n-hydroxysuccinimide, and a nonionic surfactant. The method continues by reacting the first and second microemulsions for a time sufficient to form the ultra-small chitosan nanoparticles and recovering the nanoparticles from the reacted microemulsion. The chitosan polymer may be crosslinked and may also be tagged with a fluorescent compound, a radio-opaque compound, a paramagnetic ion, a ligand specific for a predetermined biologic target, a drug, and combinations thereof. | 01-27-2011 |
20110158901 | CHITOSAN-BASED NANOPARTICLES AND METHODS FOR MAKING AND USING THE SAME - Water-dispersible chitosan-based nanoparticles comprising a cross-linked chitosan polymer are provided. The chitosan-based nanoparticles advantageously have a particle size of about 100 nm or less and may include an imaging agent, a target-specific ligand, and/or a biologically active compound bonded to the chitosan polymer. | 06-30-2011 |
20110244056 | MULTIFUNCTIONAL SILICA-BASED COMPOSITIONS AND GELS, METHODS OF MAKING THEM, AND METHODS OF USING THEM - Briefly described, embodiments of this disclosure, among others, include compositions, gels, methods for synthesizing multifunctional silica based nanoparticle gel, method of treating, preventing, or both treating and preventing, a disease in a plant species, method for simultaneously treating citrus plants for citrus canker and preventing the invasion of an Asian Citrus Psyllid (ACP) vector that carries the pathogen and spreads the citrus greening disease in citrus plants, and the like. | 10-06-2011 |
20120269729 | STABILIZED CHITOSAN-BASED NANOPARTICLES AND METHODS FOR MAKING THE SAME - A stabilized chitosan-based nanoparticle is provided having a chitosan polymer and a hydrophilic dispersing agent. In the stabilized nanoparticle, chains of the chitosan polymer electrostatically interact with chains of the hydrophilic dispersing agent to form an entangled network between the chitosan polymer and the hydrophilic dispersing agent. The stabilized chitosan-based nanoparticle has optimal particle integrity and stability properties under physiological conditions. | 10-25-2012 |
20130006007 | ACTIVATABLE NANOPROBES FOR INTRACELLULAR DRUG DELIVERY - An activatable nanoprobe is provided having a core component and an active agent associated with the core component via a bond configured to be cleaved upon exposure to an endogenous compound. | 01-03-2013 |
20130108552 | NEAR-IR INDOCYANINE GREEN DOPED MULTIMODAL SILICA NANOPARTICLES AND METHODS FOR MAKING THE SAME | 05-02-2013 |
20130108678 | AG LOADED SILICA NANOPARTICLE/NANOGEL FORMULATION, METHODS OF MAKING, AND METHODS OF USE | 05-02-2013 |
20130108702 | COPPER/SILICA NANOPARTICLES, METHODS OF MAKING, AND METHODS OF USE | 05-02-2013 |
20130129633 | MULTIMODAL NANOPARTICLES FOR NON-INVASIVE BIO-IMAGING - Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging. | 05-23-2013 |
20140308330 | CORE-SHELL QUATERNARY AMMONIUM NANOMATERIALS, METHODS AND APPLICATIONS - Quaternary ammonium materials may be immobilized onto a metal oxide nanoparticle to provide a fixed-quat nanoparticle material. A particular example uses a silicon alkoxide as a silicon source material to provide a fixed-quat SiNP/NG material composition through either acidic or basic hydrolysis of the silicon alkoxide material. Particular materials may be characterized spectroscopically to ensure that the desirable materials are properly bound. Specific applications of fixed-quat SiNP/NC material compositions in accordance with the embodiments include, but are not limited to agricultural biocide applications and tobacco smoke selective filtration applications. | 10-16-2014 |
20140369937 | ACTIVATABLE NANOPROBES FOR INTRACELLULAR DRUG DELIVERY - An activatable nanoprobe is provided having a core component and an active agent associated with the core component via a bond configured to be cleaved upon exposure to an endogenous compound. | 12-18-2014 |