Patent application number | Description | Published |
20110081297 | Novel Substituted Pyrazoles, 1,2,4-Oxadiazoles, and 1,3,4-Oxadiazoles - The present invention relates to novel amyloid binding compounds and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted pyrazole derivatives, compositions, and therapeutic uses and processes for making such compounds. | 04-07-2011 |
20110085985 | NOVEL SUBSTITUTED AZABENZOXAZOLES - The present invention relates to novel amyloid binding compounds of formula (I) and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET/) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted azabenzoxazole derivatives, compositions, and therapeutic uses and processes for making such compounds, or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof, wherein: X is O or S; A and Y independently are N, or CH; | 04-14-2011 |
Patent application number | Description | Published |
20090246782 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 10-01-2009 |
20110269190 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 11-03-2011 |
20110306109 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 12-15-2011 |
20120129156 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 05-24-2012 |
20120208987 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 08-16-2012 |
20130034845 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 02-07-2013 |
20130046508 | PATTERN RECOGNITION SYSTEM AND METHOD FOR THE DETECTION OF STUCK FLUID DROPLETS IN A FLUID DELIVERY LINE OF AN INFUSION SYSTEM - An infusion system includes a pump, a fluid delivery line, a sensor, a processor, and a memory. The fluid delivery line is connected to the pump for delivering fluid. The sensor is connected to the fluid delivery line for emitting and receiving signals to detect whether there is air in the fluid delivery line. The processor is in electronic communication with the pump and the sensor. The memory is in electronic communication with the processor. The memory includes programming code for execution by the processor. The programming code is configured to analyze the signals to determine if a stuck fluid droplet is stuck within the fluid delivery line at a location of the sensor. | 02-21-2013 |
20130085689 | FROTH DETECTION SYSTEM AND METHOD - An infusion system includes a pump, a fluid delivery line, at least one sensor, a processor, and a memory. The fluid delivery line is connected to the pump for delivering fluid. The at least one sensor is connected to the fluid delivery line for emitting and receiving signals to detect whether there is air in the fluid delivery line. The processor is in electronic communication with the pump and the at least one sensor. The memory is in electronic communication with the processor. The memory comprises programming code for execution by the processor. The programming code is configured to determine a percentage of the air within an observed volume of the fluid delivery line. | 04-04-2013 |
20130302787 | CARTRIDGE FOR USE IN AN AUTOMATED SYSTEM FOR ISOLATING AN ANALYTE FROM A SAMPLE, AND METHODS OF USE - A device for extraction or isolation of an analyte, such as a nucleic acid, a protein, or a cell, from a sample, and in particular from a biological sample, is described. Methods of using the device are also described. Further processes, such as amplification of the isolated analyte, may also be carried out within the device. | 11-14-2013 |
20130302791 | DEVICE FOR ISOLATING AN ANALYTE FROM A SAMPLE, AND METHODS OF USE - A device for extraction or isolation of an analyte, such as a nucleic acid, a protein, or a cell, from a sample, and in particular from a biological sample is described. Methods of using the device are also described. | 11-14-2013 |
20140057271 | DEVICE WITH CONTROLLED FLUID DYNAMICS, FOR ISOLATION OF AN ANALYTE FROM A SAMPLE - Devices for use in extracting an analyte of interest from a sample are described. In one embodiment, a device is comprised of a first plurality of chambers, where one or more chambers in the plurality of chambers has a deep end and a shallow end with a depth d | 02-27-2014 |
20140358081 | INFUSION SYSTEM AND METHOD OF USE WHICH PREVENTS OVER-SATURATION OF AN ANALOG-TO-DIGITAL CONVERTER - To detect air in a fluid delivery line of an infusion system, infusion fluid is pumped through a fluid delivery line adjacent to at least one sensor. A signal is transmitted and received using the at least one sensor into and from the fluid delivery line. The at least one sensor is operated, using at least one processor, at a modified frequency which is different than a resonant frequency of the at least one sensor to reduce an amplitude of an output of the signal transmitted from the at least one sensor to a level which is lower than a saturation level of the analog-to-digital converter to avoid over-saturating the analog-to-digital converter. The signal received by the at least one sensor is converted from analog to digital using an analog-to-digital converter. The at least one processor determines whether air is in the fluid delivery line based on the converted digital signal. | 12-04-2014 |
Patent application number | Description | Published |
20090099077 | TREATMENT OF RETT SYNDROME AND OTHER DISORDERS - The invention relates to methods for treatment of Rett Syndrome and other disorders of synaptic function and maturation using IGF1, (1-3)IGF-1, (1-3)IGF-1 analog(s) and/or related therapeutic molecules. | 04-16-2009 |
20090297573 | Identifying and Modulating Molecular Pathways that Mediate Nervous System Plasticity - The present invention provides methods for identifying genes and pathways involved in plasticity. The invention applies some of these methods to identify genes that are differentially regulated in at least a portion of the nervous system of an individual subjected to conditions known to result in altered nervous system plasticity, i.e., dark rearing (DR) or monocular deprivation (MD). The genes are targets for pharmacological agents that modify plasticity. The invention also identifies biological pathways that are enriched in genes that are differentially regulated under conditions known to result in altered nervous system plasticity. The present invention further provides methods and compositions for modifying plasticity in the nervous system of a subject. The invention includes a method for modifying plasticity in the nervous system of a subject comprising administering a plasticity-modifying agent to the subject, wherein the plasticity-enhancing agent modulates a gene or pathway that is differentially regulated in developmental conditions that alter nervous system plasticity (e.g., DR or MD). The methods and compositions may be administered to a subject suffering from damage to the nervous system or from a neuropsychiatric disorder in order to enhance recovery, reorganization, or function of the nervous system. The methods optionally include administering a proteolysis-enhancing agent to the subject. | 12-03-2009 |
20100298304 | DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDERS - The invention relates to methods for diagnosis and treatment of autism spectrum disorders, particularly for autism spectrum disorders characterized by increased head size (circumference) and deficits in social behavior. | 11-25-2010 |
20120093376 | NOISE REDUCTION OF IMAGING DATA - The present invention relates to systems and methods for reducing noise in image data. Preferred embodiments relate to methods for analyzing two-photon in vivo imaging of biological systems. With neuronal population imaging with subcellular resolution, this modality offers an approach for gaining a fundamental understanding of brain anatomy and physiology. Analysis of calcium imaging data requires denoising, that is separating the signal from complex physiological noise. To analyze two-photon brain imaging data, for example, harmonic regression plus colored noise model and an efficient cyclic descent algorithm for parameter estimation. This approach reliably separates stimulus-evoked fluorescence response from background activity and noise, assesses goodness of fit, and estimates confidence intervals and signal-to-noise ratio. | 04-19-2012 |
20120177630 | TREATMENT OF RETT SYNDROME AND OTHER DISORDERS - The invention relates to methods for treatment of Rett Syndrome and other disorders of synaptic function and maturation using IGF1, (1-3)IGF-1, (1-3)IGF-1 analog(s) and/or related therapeutic molecules. | 07-12-2012 |
20150126496 | DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDERS - The invention relates to methods for diagnosis and treatment of autism spectrum disorders, particularly for autism spectrum disorders characterized by increased head size (circumference) and deficits in social behavior. | 05-07-2015 |
20150174212 | IDENTIFYING AND MODULATING MOLECULAR PATHWAYS THAT MEDIATE NERVOUS SYSTEM PLASTICITY - The present invention provides methods for identifying genes and pathways involved in plasticity. The invention applies some of these methods to identify genes that are differentially regulated in at least a portion of the nervous system of an individual subjected to conditions known to result in altered nervous system plasticity, i.e., dark rearing (DR) or monocular deprivation (MD). The genes are targets for pharmacological agents that modify plasticity. The invention also identifies biological pathways that are enriched in genes that are differentially regulated under conditions known to result in altered nervous system plasticity. The present invention further provides methods and compositions for modifying plasticity in the nervous system of a subject. The invention includes a method for modifying plasticity in the nervous system of a subject comprising administering a plasticity-modifying agent to the subject, wherein the plasticity-enhancing agent modulates a gene or pathway that is differentially regulated in developmental conditions that alter nervous system plasticity (e.g., DR or MD). The methods and compositions may be administered to a subject suffering from damage to the nervous system or from a neuropsychiatric disorder in order to enhance recovery, reorganization, or function of the nervous system. The methods optionally include administering a proteolysis-enhancing agent to the subject. | 06-25-2015 |
Patent application number | Description | Published |
20110145559 | SYSTEM AND METHOD FOR CONTROLLING CENTRAL PROCESSING UNIT POWER WITH GUARANTEED STEADY STATE DEADLINES - A method of dynamically controlling a central processing unit is disclosed. The method may include determining when a CPU enters a steady state, calculating an optimal frequency for the CPU when the CPU enters a steady state, guaranteeing a steady state CPU utilization, and guaranteeing a steady state CPU utilization deadline. | 06-16-2011 |
20110145605 | SYSTEM AND METHOD FOR DYNAMICALLY CONTROLLING A PLURALITY OF CORES IN A MULTICORE CENTRAL PROCESSING UNIT BASED ON TEMPERATURE - A method of controlling power within a multicore central processing unit (CPU) is disclosed. The method may include monitoring a die temperature, determining a degree of parallelism within a workload of the CPU, and powering one or more cores of the CPU up or down based on the degree of parallelism, the die temperature, or a combination thereof. | 06-16-2011 |
20110145615 | SYSTEM AND METHOD FOR CONTROLLING CENTRAL PROCESSING UNIT POWER BASED ON INFERRED WORKLOAD PARALLELISM - A method of dynamically controlling power within a multicore CPU is disclosed and may include receiving a degree of parallelism in a workload of a zeroth core and determining whether the degree of parallelism in the workload of the zeroth core is equal to a first wake condition. Further, the method may include determining a time duration for which the first wake condition is met when the degree of parallelism in the workload of the zeroth core is equal to the first wake condition and determining whether the time duration is equal to a first confirm wake condition. The method may also include invoking an operating system to power up a first core when the time duration is equal to the first confirm wake condition. | 06-16-2011 |
20110145616 | SYSTEM AND METHOD FOR CONTROLLING CENTRAL PROCESSING UNIT POWER IN A VIRTUALIZED SYSTEM - A method of dynamically controlling power within a multicore central processing unit is disclosed and includes executing a plurality of virtual cores, virtually executing one or more tasks, one or more threads, or a combination thereof at the virtual cores, and physically executing one or more tasks, one or more threads, or a combination thereof at a zeroth physical core. The method may further include receiving a degree of parallelism in a workload of a plurality of virtual cores and determining whether the degree of parallelism in the workload of the virtual cores is equal to a first wake condition. | 06-16-2011 |
20110145617 | SYSTEM AND METHOD FOR CONTROLLING CENTRAL PROCESSING UNIT POWER WITH GUARANTEED TRANSIENT DEADLINES - A method of controlling power at a central processing unit is disclosed. The method may include moving to a higher CPU frequency after a transient performance deadline has expired, entering an idle state, and resetting the transient performance deadline based on an effective transient budget. | 06-16-2011 |
20110145624 | SYSTEM AND METHOD FOR ASYNCHRONOUSLY AND INDEPENDENTLY CONTROLLING CORE CLOCKS IN A MULTICORE CENTRAL PROCESSING UNIT - A method of controlling core clocks in a multicore central processing unit is disclosed and may include executing a zeroth dynamic clock and voltage scaling (DCVS) algorithm on a zeroth core and executing a first DCVS algorithm on a first core. The zeroth DCVS algorithm may operable to independently control a zeroth clock frequency associated with the zeroth core and the first DCVS algorithm may be operable to independently control a first clock frequency associated with the first core. | 06-16-2011 |
20110145824 | SYSTEM AND METHOD FOR CONTROLLING CENTRAL PROCESSING UNIT POWER WITH REDUCED FREQUENCY OSCILLATIONS - A method of dynamically controlling power within a central processing unit is disclosed and may include entering an idle state, reviewing a previous busy cycle immediately prior to the idle state, and based on the previous busy cycle determining a CPU frequency for a next busy cycle. | 06-16-2011 |
20120179303 | METHOD AND SYSTEM FOR MANAGING THERMAL POLICIES OF A PORTABLE COMPUTING DEVICE - A method and system for managing one or more thermal policies of a portable computing device (PCD) includes monitoring temperature of the portable computing device with internal thermal sensors and external thermal sensors. If a change in temperature has been detected by at least one thermal sensor, then a thermal policy manager may increase a frequency in which temperature readings are detected by the thermal sensors. The thermal policy manager may also determine if a current temperature of the portable computing device as detected by one or more of the thermal sensors falls within one or more predetermined thermal states. Each thermal state may be assigned a unique set of thermal mitigation techniques. Each set of thermal mitigation techniques may be different from one another. The sets of thermal mitigation techniques may differ according to quantity of techniques and impacts on performance of the PCD. | 07-12-2012 |
20120179416 | METHOD AND SYSTEM FOR MANAGING THERMAL POLICIES OF A PORTABLE COMPUTING DEVICE - A method and system for managing one or more thermal policies of a portable computing device (PCD) includes monitoring temperature of the portable computing device with internal thermal sensors and external thermal sensors. If a change in temperature has been detected by at least one thermal sensor, then a thermal policy manager may increase a frequency in which temperature readings are detected by the thermal sensors. The thermal policy manager may also determine if a current temperature of the portable computing device as detected by one or more of the thermal sensors falls within one or more predetermined thermal states. Each thermal state may be assigned a unique set of thermal mitigation techniques. Each set of thermal mitigation techniques may be different from one another. The sets of thermal mitigation techniques may differ according to quantity of techniques and impacts on performance of the PCD. | 07-12-2012 |
20120179441 | METHOD AND SYSTEM FOR CONTROLLING THERMAL LOAD DISTRIBUTION IN A PORTABLE COMPUTING DEVICE - Methods and systems for managing thermal load distribution on a portable computing device (“PCD”) include storing on a PCD a plurality of thermal load steering scenarios which identify simulated thermal load conditions for the PCD, corresponding simulated workloads that produced the simulated thermal load conditions, and thermal load steering parameters for steering the simulated thermal load to a predetermined spatial location on the PCD. A scheduled workload for the PCD is monitored to identify a match with one of the thermal load steering scenarios so that the workload may be scheduled according to a thermal load steering parameter. Another method includes initiating a thermal mitigation technique on a PCD and determining a current graphical load being processed by the PCD. A graphics feature associated with the current graphical load is identified. The graphics feature is then disabled while maintaining a frame rate to reduce temperature of the PCD. | 07-12-2012 |
20120271481 | METHOD AND SYSTEM FOR THERMAL LOAD MANAGEMENT IN A PORTABLE COMPUTING DEVICE - Methods and systems for leveraging temperature sensors in a portable computing device (“PCD”) are disclosed. The sensors may be placed within the PCD near known thermal energy producing components such as a central processing unit (“CPU”) core, graphical processing unit (“GPU”) core, power management integrated circuit (“PMIC”), power amplifier, etc. The signals generated by the sensors may be monitored and used to trigger drivers running on the processing units. The drivers are operable to cause the reallocation of processing loads associated with a given component's generation of thermal energy, as measured by the sensors. In some embodiments, the processing load reallocation is mapped according to parameters associated with pre-identified thermal load scenarios. In other embodiments, the reallocation occurs in real time, or near real time, according to thermal management solutions generated by a thermal management algorithm that may consider CPU and/or GPU performance specifications along with monitored sensor data. | 10-25-2012 |
20120281558 | TEMPERATURE-DRIVEN AIRLINK SELECTION IN A MULTI-MODE WIRELESS DEVICE - A method and system for temperature-driven airlink selection in a multi-mode wireless device is disclosed. The method may include monitoring a temperature in the multi-mode wireless device while the multi-mode wireless device operates in a first airlink mode, determining whether to switch the airlink mode of the multi-mode wireless device in response to a change in the monitored temperature, and switching the multi-mode wireless device to operate in a second airlink mode in response to a determination to switch the airlink mode. | 11-08-2012 |
20130073875 | SYSTEM AND METHOD FOR MANAGING THERMAL ENERGY GENERATION IN A HETEROGENEOUS MULTI-CORE PROCESSOR - Various embodiments of methods and systems for controlling and/or managing thermal energy generation on a portable computing device that contains a heterogeneous multi-core processor are disclosed. Because individual cores in a heterogeneous processor may exhibit different processing efficiencies at a given temperature, thermal mitigation techniques that compare performance curves of the individual cores at their measured operating temperatures can be leveraged to manage thermal energy generation in the PCD by allocating and/or reallocating workloads among the individual cores based on the performance curve comparison. | 03-21-2013 |
20130074085 | SYSTEM AND METHOD FOR CONTROLLING CENTRAL PROCESSING UNIT POWER WITH GUARANTEED TRANSIENT DEADLINES - Methods, systems and devices that include a dynamic clock and voltage scaling (DCVS) solution configured to compute and enforce performance guarantees to ensure that a processor does not remain in a busy state (e.g., due to transient workloads) for more than a predetermined amount of time above that which is required for that processor to complete its pre-computed steady state workload. The DCVS may adjust the frequency and/or voltage of a processor based on a variable delay to ensure that the processing core only falls behind its steady state workload by, at most, a predefined maximum amount of work, irrespective of the operating frequency or voltage of the processor. | 03-21-2013 |
20130097443 | DYNAMIC VOLTAGE AND CLOCK SCALING CONTROL BASED ON RUNNING AVERAGE, VARIANT AND TREND - The aspects enable a computing device or microprocessor to scale the frequency and/or voltage of a processor to an optimal value balancing performance and power savings in view of a current processor workload. Busy and/or idle duration statistics are calculated from the processor during execution. The statistics may include a running average busy and/or idle duration or idle/busy ratio, a variance of the running average and a trend of the running average. Current busy or idle durations or an idle-to-busy ratio may be computed based on collected statistics. The current idle-to-busy ratio may be compared to a target idle-to-busy ratio and the frequency/voltage of the processor may be adjusted based on the results of the comparison to drive the current running average toward the target value. The target value of idle-to-busy ratio may be adjusted based on the calculated variance and/or trend values. | 04-18-2013 |
20130097609 | System and Method for Determining Thermal Management Policy From Leakage Current Measurement - Various embodiments of methods and systems for determining the thermal status of processing components within a portable computing device (“PCD”) by measuring leakage current on power rails associated with the components are disclosed. One such method involves measuring current on a power rail after a processing component has entered a “wait for interrupt” mode. Advantageously, because a processing component may “power down” in such a mode, any current remaining on the power rail associated with the processing component may be attributable to leakage current. Based on the measured leakage current, a thermal status of the processing component may be determined and thermal management policies consistent with the thermal status of the processing component implemented. Notably, it is an advantage of embodiments that the thermal status of a processing component within a PCD may be established without the need to leverage temperature sensors. | 04-18-2013 |
20130132972 | THERMALLY DRIVEN WORKLOAD SCHEDULING IN A HETEROGENEOUS MULTI-PROCESSOR SYSTEM ON A CHIP - Various embodiments of methods and systems for thermally aware scheduling of workloads in a portable computing device that contains a heterogeneous, multi-processor system on a chip (“SoC”) are disclosed. Because individual processing components in a heterogeneous, multi-processor SoC may exhibit different processing efficiencies at a given temperature, and because more than one of the processing components may be capable of processing a given block of code, thermally aware workload scheduling techniques that compare performance curves of the individual processing components at their measured operating temperatures can be leveraged to optimize quality of service (“QoS”) by allocating workloads in real time, or near real time, to the processing components best positioned to efficiently process the block of code. | 05-23-2013 |
20130151879 | SYSTEM AND METHOD FOR CONTROLLING CENTRAL PROCESSING UNIT POWER WITH GUARANTEED TRANSIENT DEADLINES - Methods, systems and devices that include a dynamic clock and voltage scaling (DCVS) solution configured to compute and enforce performance guarantees for a group of processors to ensure that the processors does not remain in a busy state (e.g., due to transient workloads) for a combined period that is more than a predetermined amount of time above that which is required for one of the processors to complete its pre-computed steady state workload. The DCVS may adjust the frequency and/or voltage of one or more of the processors based on a variable delay to ensure that the multiprocessor system only falls behind its steady state workload by, at most, a predefined maximum amount of work, irrespective of the operating frequency or voltage of the processors. | 06-13-2013 |
20140181542 | System and Method For Dynamically Controlling A Plurality Of Cores In A Multicore Central Processing Unit Based On Tempature - A method of controlling power within a multicore central processing unit (CPU) is disclosed. The method may include monitoring a die temperature, determining a degree of parallelism within a workload of the CPU, and powering one or more cores of the CPU up or down based on the degree of parallelism, the die temperature, or a combination thereof. | 06-26-2014 |
20140189710 | THERMALLY DRIVEN WORKLOAD SCHEDULING IN A HETEROGENEOUS MULTI-PROCESSOR SYSTEM ON A CHIP - Various embodiments of methods and systems for thermally aware scheduling of workloads in a portable computing device that contains a heterogeneous, multi-processor system on a chip (“SoC”) are disclosed. Because individual processing components in a heterogeneous, multi-processor SoC may exhibit different processing efficiencies at a given temperature, and because more than one of the processing components may be capable of processing a given block of code, thermally aware workload scheduling techniques that compare performance curves of the individual processing components at their measured operating temperatures can be leveraged to optimize quality of service (“QoS”) by allocating workloads in real time, or near real time, to the processing components best positioned to efficiently process the block of code. | 07-03-2014 |