Strongin, US
Alex Strongin, San Diego, CA US
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20090209615 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS - The invention provides methods to treat neurological disorders, opthalmological disorders, or a combination thereof by administering a compound that inhibits MMPs. A compound that inhibits MMPs is represented by the compound of formula (I) shown herein. | 08-20-2009 |
20100298390 | INHIBITION OF LETHAL FACTOR PROTEASE ACTIVITY FROM ANTHRAX TOXIN - The present invention provides compounds that efficiently and specifically inhibit lethal factor (LF) protease activity of anthrax toxin. | 11-25-2010 |
Alex Strongin, La Jolla, CA US
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20090029924 | Targeting Host Proteinases as a Therapeutic Strategy Against Viral and Bacterial Pathogens - Disclosed are compositions and methods for preventing or reducing harm resulting from pathogen infection. For example, disclosed are peptides that inhibit the processing of toxins normally cleaved by proprotein convertase enzymes. | 01-29-2009 |
20150051138 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES - Disclosed herein are Furin/PC inhibitors for inhibiting Furin and other Propprotein Convertases. Method of making the Furin/PC inhibitors, chemical and biological characterization of the Furin/PC inhibitors, and the use of the Furin/PC inhibitors to treat infectious diseases, cancers, and inflammatory/autoimmune disorders, are also disclosed. | 02-19-2015 |
20150073054 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES - Disclosed herein are Furin/PC inhibitors for inhibiting Furin and other Propprotein Convertases. Method of making the Furin/PC inhibitors, chemical and biological characterization of the Furin/PC inhibitors, and the use of the Furin/PC inhibitors to treat infectious diseases, cancers, and inflammatory/autoimmune disorders, are also disclosed. | 03-12-2015 |
Alex Y. Strongin, San Diego, CA US
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20120178909 | Novel Screening Strategies for the Identification of Binders - The present invention discloses novel screening strategies for the identification of binders that target the active site of enzymatic antigens. The present invention also discloses antigen-binding moieties which bind to the NS2B-NS3 Proteinase of West Nile Virus, in particular binders which bind to the active site, thereby inhibiting the enzymatic activity of the proteinase. The antigen-binding moieties of the present invention have numerous therapeutic and diagnostic applications. | 07-12-2012 |
Boris Strongin, Redwood City, CA US
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20100071035 | METHODS AND SYSTEMS FOR SECURELY MANAGING VIRTUALIZATION PLATFORM - Virtualization platforms and management clients therefor are communicatively coupled to one another via a control layer logically disposed therebetween. The control layer is configured to proxy virtualization management commands from the management clients to the virtualization platforms, but only after successful authentication of users (which may include automated agents and processes) issuing those commands and privileges of those users as defined by access control information accessible to the control layer. The control layer may be instantiated as an application running on a physical appliance logically interposed between the virtualization platforms and management clients, or a software package running on dedicated hardware logically interposed between the virtualization platforms and management clients, or as an application encapsulated in a virtual machine running on a compatible virtualization platform logically interposed between the virtualization platforms and management clients. | 03-18-2010 |
20100169948 | INTELLIGENT SECURITY CONTROL SYSTEM FOR VIRTUALIZED ECOSYSTEMS - Resources of a virtualized ecosystem are intelligently secured by defining and analyzing object handling security control information for one or more logical resources in the virtualized ecosystem and deriving therefrom object properties for each of the logical resources involved in the execution of a virtual machine in any given context within the virtualized ecosystem. | 07-01-2010 |
20120036561 | METHODS AND SYSTEMS FOR SECURELY MANAGING VIRTUALIZATION PLATFORM - Virtualization platforms and management clients therefor are communicatively coupled to one another via a control layer logically disposed therebetween. The control layer is configured to proxy virtualization management commands from the management clients to the virtualization platforms, but only after successful authentication of users (which may include automated agents and processes) issuing those commands and privileges of those users as defined by access control information accessible to the control layer. The control layer may be instantiated as an application running on a physical appliance logically interposed between the virtualization platforms and management clients, or a software package running on dedicated hardware logically interposed between the virtualization platforms and management clients, or as an application encapsulated in a virtual machine running on a compatible virtualization platform logically interposed between the virtualization platforms and management clients. | 02-09-2012 |
20130138971 | INTELLIGENT SECURITY CONTROL SYSTEM FOR VIRTUALIZED ECOSYSTEMS - Resources of a virtualized ecosystem are intelligently secured by defining and analyzing object handling security control information for one or more logical resources in the virtualized ecosystem and deriving therefrom object properties for each of the logical resources involved in the execution of a virtual machine in any given context within the virtualized ecosystem. | 05-30-2013 |
Daniel E. Strongin, Chicago, IL US
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20100184954 | MONOMERIC RED FLUORESCENT PROTEINS - Disclosed are sequences encoding monomeric variants of DsRed fluorescent proteins and methods of use. | 07-22-2010 |
20110020784 | RED FLUORESCENT PROTEINS WITH ENHANCED BACTERIAL EXPRESSION, INCREASED BRIGHTNESS AND REDUCED AGGREGATION - Polynucleotides encoding variant polypeptides of DsRed are provided herein. The DsRed variants have increased bacterial expression, reduced aggregation, increased solubility, shifted emission spectra or increased brightness relative to a wild-type DsRed. | 01-27-2011 |
Daniel R. Strongin, Wynnewood, PA US
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20120021130 | METHOD FOR INHIBITING DECOMPOSITION OF METAL SULFIDE-CONTAINING MATERIAL - This invention provides methods of producing a crosslinked lipid coating on a metal sulfide-containing material using a chemical initiator. The crosslinked lipid coating attached to the surface of the material prevents dissolution or oxidation of the material. The methods may be useful to prevent oxidation and leaking of sulfide-containing material in the environment and may be used in the control of environmental pollution. | 01-26-2012 |
Geoffrey Strongin, Tigard, OR US
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20140090074 | ENHANCED PRIVACY FOR PROVISION OF COMPUTER VISION - Methods, apparatuses and storage medium associated with providing enhanced privacy during usage of computer vision are disclosed. In embodiments, an apparatus may include one or more privacy indicators to indicate one or more privacy conditions of the apparatus in association with provision of computer vision on the apparatus. The apparatus may further include a privacy engine coupled with the one or more privacy indicators, and configured to pre-process images from an image source of the apparatus associated with the provision of computer vision to the apparatus, to increase privacy for a user of the apparatus, and to control the one or more privacy indicators. In embodiments, the apparatus may include means for blanking out one or more pixels with depth values identified as greater than a threshold. Other embodiments may be described and claimed. | 03-27-2014 |
20150040242 | ENHANCED PRIVACY FOR PROVISION OF COMPUTER VISION - Methods, apparatuses and storage medium associated with providing enhanced privacy during usage of computer vision are disclosed. In embodiments, an apparatus may include one or more privacy indicators to indicate one or more privacy conditions of the apparatus in association with provision of computer vision on the apparatus. The apparatus may further include a privacy engine coupled with the one or more privacy indicators, and configured to pre-process images from an image source of the apparatus associated with the provision of computer vision to the apparatus, to increase privacy for a user of the apparatus, and to control the one or more privacy indicators. In embodiments, the apparatus may include means for blanking out one or more pixels with depth values identified as greater than a threshold. Other embodiments may be described and claimed. | 02-05-2015 |
Geoffrey Strongin, Beaverton, OR US
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20140157349 | Verified Sensor Data Processing - Sensor data may be filtered in a secure environment. The filtering may limit distribution of the sensor data. Filtering may modify the sensor data, for example, to prevent identification of a person depicted in a captured image or to prevent acquiring a user's precise location. Filtering may also add or require other data use controls to access the data. Attestation that a filter policy is being applied and working properly or not may be provided as well. | 06-05-2014 |
Geoffrey S. Strongin, Tigard, OR US
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20120030730 | PROVIDING A MULTI-PHASE LOCKSTEP INTEGRITY REPORTING MECHANISM - In one embodiment, a processor can enforce a blacklist and validate, according to a multi-phase lockstep integrity protocol, a device coupled to the processor. Such enforcement may prevent the device from accessing one or more resources of a system prior to the validation. The blacklist may include a list of devices that have not been validated according to the multi-phase lockstep integrity protocol. Other embodiments are described and claimed. | 02-02-2012 |
20140129810 | Known Good Code for On-Chip Device Management - In one embodiment, a processor comprises a programmable map and a circuit. The programmable map is configured to store data that identifies at least one instruction for which an architectural modification of an instruction set architecture implemented by the processor has been defined, wherein the processor does not implement the modification. The circuitry is configured to detect the instruction or its memory operands and cause a transition to Known Good Code (KGC), wherein the KGC is protected from unauthorized modification and is provided from an authenticated entity. The KGC comprises code that, when executed, emulates the modification. In another embodiment, an integrated circuit comprises at least one processor core; at least one other circuit; and a KGC source configured to supply KGC to the processor core for execution. The KGC comprises interface code for the other circuit whereby an application executing on the processor core interfaces to the other circuit through the KGC. | 05-08-2014 |
20140189261 | ACCESS TYPE PROTECTION OF MEMORY RESERVED FOR USE BY PROCESSOR LOGIC - A processor of an aspect includes operation mode check logic to determine whether to allow an attempted access to an operation mode and access type protected memory based on an operation mode that is to indicate whether the attempted access is by an on-die processor logic. Access type check logic is to determine whether to allow the attempted access to the operation mode and access type protected memory based on an access type of the attempted access to the operation mode and access type protected memory. Protection logic is coupled with the operation mode check logic and is coupled with the access type check logic. The protection logic is to deny the attempted access to the operation mode and access type protected memory if at least one of the operation mode check logic and the access type check logic determines not to allow the attempted access. | 07-03-2014 |
Geoffrey S. Strongin, Beaverton, OR US
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20130283369 | Providing A Multi-Phase Lockstep Integrity Reporting Mechanism - In one embodiment, a processor can enforce a blacklist and validate, according to a multi-phase lockstep integrity protocol, a device coupled to the processor. Such enforcement may prevent the device from accessing one or more resources of a system prior to the validation. The blacklist may include a list of devices that have not been validated according to the multi-phase lockstep integrity protocol. Other embodiments are described and claimed. | 10-24-2013 |
20140157410 | Secure Environment for Graphics Processing Units - In accordance with some embodiments, a protected execution environment may be defined for a graphics processing unit. This framework not only protects the workloads from malware running on the graphics processing unit but also protects those workloads from malware running on the central processing unit. In addition, the trust framework may facilitate proof of secure execution by measuring the code and data structures used to execute the workload. If a part of the trusted computing base of this framework or protected execution environment is compromised, that part can be patched remotely and the patching can be proven remotely throughout attestation in some embodiments. | 06-05-2014 |
20140359754 | Providing A Multi-Phase Lockstep Integrity Reporting Mechanism - In one embodiment, a processor can enforce a blacklist and validate, according to a multi-phase lockstep integrity protocol, a device coupled to the processor. Such enforcement may prevent the device from accessing one or more resources of a system prior to the validation. The blacklist may include a list of devices that have not been validated according to the multi-phase lockstep integrity protocol. Other embodiments are described and claimed. | 12-04-2014 |
Mikhail P. Strongin, Northbrook, IL US
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20140140837 | FLOW CONDITIONING FEATURE FOR SUCTION DIFFUSER - A suction diffuser or arrangement is provided featuring a main suction diffuser body and a flow conditioning arrangement. The main suction diffuser body is configured with an inlet to receive an incoming fluid flow, an interior cavity to receive the incoming fluid from the inlet, and an outlet to receive the incoming fluid from the interior cavity and provide an outgoing fluid. The flow conditioning arrangement is configured in relation to the inlet and also comprises a flow conditioning portion having at least one inwardly contoured surface, configured to extend into the interior cavity, diffuse the incoming fluid passing from the inlet into the interior cavity, and provide a flow conditioning that produces a uniform flow of the outgoing fluid by directing the incoming fluid towards the outlet, based at least partly on a contoured design corresponding to the at least one inwardly contoured surface. | 05-22-2014 |
Robert Strongin, Baton Rouge, LA US
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20100273763 | ORGANOMETALLIC COMPLEXES AS THERAPEUTIC AGENTS - This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity. | 10-28-2010 |
20130023511 | ORGANOMETALLIC COMPLEXES AS THERAPEUTIC AGENTS - This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity. | 01-24-2013 |
20140371193 | ORGANOMETALLIC COMPLEXES AS THERAPEUTIC AGENTS - This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity. | 12-18-2014 |
Robert Strongin, Portland, OR US
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20140206095 | FLUORESCENCE DETECTION OF CYSTEINE AND HOMOCYSTEINE - Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula where R | 07-24-2014 |
Robert M. Strongin, Portland, OR US
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20100051826 | Fluorescent Xanthenes and White Light Fluorophores - Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in “multiplexing” techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges. | 03-04-2010 |
20100291689 | Lanthanide Complexes as Fluorescent Indicators for Neutral Sugars and Cancer Diagnosis - A group of water-soluble salophene-lanthanide complexes and other salophene-metal complexes are useful for purposes including: (i) detecting neutral carbohydrates at physiologically-relevant pH, (ii) the selective detection of gangliosides, and (iii) the selective detection of lysophosphatidic acid (LPA) in the presence of phosphatidic acid. The selective detection of LPA is useful in diagnosing ovarian and other cancers. | 11-18-2010 |
Robert M. Strongin, Baton Rouge, LA US
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20080261315 | Colorimetric and Fluorometric Determination of Homocysteine and Cysteine - Colorimetric and fluorometric methods are disclosed for the rapid, accurate, selective, and inexpensive detection of homocysteine, or of homocysteine and cysteine, or of cysteine. The methods may be employed with materials that are readily available commercially. The novel methods are selective for homocysteine, for cysteine, or for total homocysteine and cysteine, and do not cross-react substantially with chemically-related species such as glutathione. The homocysteine-selective method does not have substantial cross-reactivity to the very closely related species cysteine. The cysteine-selective method does not have substantial cross-reactivity to the very closely related species homocysteine. The methods may be used, for example, in a direct assay of human blood plasma for homocysteine levels. | 10-23-2008 |
Robert Michael Strongin, Portland, OR US
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20120276649 | THIOL DETECTION - Embodiments of compounds for selectively detecting a thiol are disclosed. In some embodiments, the compounds are bridged viologens, and the compounds are capable of reacting with homocysteine and/or glutathione in a buffered solution to produce a change in the solution's absorbance spectrum and/or emission spectrum. Also disclosed are embodiments of methods and kits for detecting homocysteine and/or glutathione with the disclosed bridged viologens. | 11-01-2012 |
20140120628 | NEAR-INFRARED FLUORESCENT DYES WITH LARGE STOKES SHIFTS - Embodiments of near-infrared (NIR) dyes are disclosed, along with methods and kits for detecting analytes with the NIR dyes. The NIR dyes have a structure according to the general structure | 05-01-2014 |
20140127820 | ANALYTE DETECTION USING NEAR-INFRARED FLUOROPHORES - Embodiments of compounds for selectively detecting an analyte are disclosed, along with methods and kits for detecting analytes with the compounds. The compounds are bridged viologen conjugates including at least one fluorophore according to the general structure | 05-08-2014 |
Wendy Strongin, Far Hills, NJ US
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20130280696 | DEVICES AND METHODS FOR DETECTING ANALYTE IN BODILY FLUID - A test device for detecting an analyte in a sample of bodily fluid, includes at least one hollow needle configured to obtain a sample of bodily fluid, an enclosure configured to contain a reagent, a portion configured to open the enclosure, a test results indicator configured to absorb the bodily fluid, the test results indicator including at least one test zone configured to indicate the presence of an analyte in the bodily fluid when the at least one test zone is in fluidic contact with the reagent, a housing, and a cover configured to be movable with respect to the housing between a closed position precluding access to the at least one hollow needle and an open position permitting access to the at least one hollow needle. Additionally, the at least one hollow needle is in fluid communication with the test results indicator. | 10-24-2013 |