Stevens, CA
Andrew Stevens, San Francisco, CA US
Patent application number | Description | Published |
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20090088248 | GAME CONTROLLING APPARATUS FOR PEDALING MOTION - A game controlling apparatus designed for using a pedaling (or winding) motion to control a video game. The game controlling apparatus preferably includes a platform element adapted to secure a game controller and at least a first handle and a second handle, each handle being capable of rotation about an axis of rotation relative to the platform element. The game controlling apparatus additionally may include an attachment mechanism adapted to secure the game controller to the platform. The first and second handle are preferably positioned on opposite sides of the platform element and on opposite ends of the platform element so that a pedaling motion while gripping the first and second handle will produce rotation of the game controller preferably about a centrally located point on the game controller. | 04-02-2009 |
20140143121 | System and Method for Programming a Trading System - A trading system includes a server co-located at a financial exchange, a programmable logic device, a logic programmer, a user account that is accessible over a network connection a code storage device that stores code associated with the user account to be programmed into the programmable logic device and a network connection between the programmable logic device and a financial exchange. A method of programming a trading system connected to a financial exchange includes transmitting code to a server, storing code on a server, compiling the code and at least one code library by synthesizing logic elements and mapping logic elements to logic elements in a programmable logic device, and programming a programmable logic device connected to a financial exchange. | 05-22-2014 |
Andrew G. Stevens, Palo Alto, CA US
Patent application number | Description | Published |
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20120152626 | ROBOTIC SYSTEM AND METHODS OF USE - A robotic system that can have a body and four flippers is described. Any or all of the flippers can be rotated. The flippers can have self-cleaning tracks. The tracks can be driven or passive. The robotic system can be controlled by, and send audio and/or video to and/or from, a remote operator control module. The methods of using and making the robotic system are also described. | 06-21-2012 |
20120152627 | ROBOTIC SYSTEM AND METHODS OF USE - A robotic system that can have a body and four flippers is described. Any or all of the flippers can be rotated. The flippers can have self-cleaning tracks. The tracks can be driven or passive. The robotic system can be controlled by, and send audio and/or video to and/or from, a remote operator control module. The methods of using and making the robotic system are also described. | 06-21-2012 |
20130100986 | METHOD OF ADAPTING A WIRELESS SYSTEM FOR USE IN A GEOGRAPHIC LOCATION - A wireless communication system comprises a first computing device and a second computing device, wherein the first computing device and the second computing device communicate over a wireless channel that is selected based in part on a geographic location of at least one of the first computing device and the second computing device. The wireless channel that is selected provides long range communications, on the order of 60 miles and more. The computing devices may be a robot controller and a controlled robot, or they may be wireless router and a computing device configured with a wireless transceiver. | 04-25-2013 |
20130101002 | METHOD OF DISPLAYING A DIGITAL SIGNAL - Devices communicate with one another over a wireless channel according to a signal strength of a signal transmitted over the wireless channel. Digital data captured at a source is transmitted over the wireless channel at a first quality if the signal strength or latency is above a threshold and at a second quality if the signal strength or latency is below the threshold. In addition, noise can be inserted into the transmitted digital data as a way to alert the recipient of the signal of signal strength degradation at a finer granularity. | 04-25-2013 |
20130306385 | ROBOTIC SYSTEM AND METHODS OF USE - A robotic system that can have a body and four flippers is described. Any or all of the flippers can be rotated. The flippers can have self-cleaning tracks. The tracks can be driven or passive. The robotic system can be controlled by and send audio and/or video to and/or from, a remote operator control module. The methods of using and making the robotic system are also described. | 11-21-2013 |
20140076642 | ROBOTIC SYSTEM AND METHODS OF USE - A robotic system that can have a body and four flippers is described. Any or all of the flippers can be rotated. The flippers can have self-cleaning tracks. The tracks can be driven or passive. The robotic system can be controlled by, and send audio and/or video to and/or from, a remote operator control module. The methods of using and making the robotic system are also described. | 03-20-2014 |
20140266682 | ENVIRONMENTAL MONITORING DEVICE - An environmental monitoring device that monitors the operation of a legacy electronic device is described. In particular, a sensor in the environmental monitoring device provides sensor data that represents an environmental condition in an external environment that includes the environmental monitoring device. This environmental condition is associated with the operation of the legacy electronic device in the external environment. The environmental monitoring device analyzes the sensor data and provides feedback about the operation of the legacy electronic device based on the analyzed sensor data. Moreover, the sensor provides the sensor data without or excluding communication and/or electrical coupling between the environmental monitoring device and the legacy electronic device. In this way, the environmental monitoring device facilitates monitoring, analysis and feedback of the sensor data without directly interacting with the legacy electronic device. | 09-18-2014 |
20140266777 | ENVIRONMENTAL MONITORING DEVICE - An environmental monitoring device that monitors the operation of a legacy electronic device is described. In particular, a sensor in the environmental monitoring device provides sensor data that represents an environmental condition in an external environment that includes the environmental monitoring device. This environmental condition is associated with the operation of the legacy electronic device in the external environment. The environmental monitoring device analyzes the sensor data and provides feedback about the operation of the legacy electronic device based on the analyzed sensor data. Moreover, the sensor provides the sensor data without or excluding communication and/or electrical coupling between the environmental monitoring device and the legacy electronic device. In this way, the environmental monitoring device facilitates monitoring, analysis and feedback of the sensor data without directly interacting with the legacy electronic device. | 09-18-2014 |
20140270176 | ENVIRONMENTAL MONITORING DEVICE - An environmental monitoring device that monitors the operation of a legacy electronic device is described. In particular, a sensor in the environmental monitoring device provides sensor data that represents an environmental condition in an external environment that includes the environmental monitoring device. This environmental condition is associated with the operation of the legacy electronic device in the external environment. The environmental monitoring device analyzes the sensor data and provides feedback about the operation of the legacy electronic device based on the analyzed sensor data. Moreover, the sensor provides the sensor data without or excluding communication and/or electrical coupling between the environmental monitoring device and the legacy electronic device. In this way, the environmental monitoring device facilitates monitoring, analysis and feedback of the sensor data without directly interacting with the legacy electronic device. | 09-18-2014 |
20140277625 | ENVIRONMENTAL MONITORING DEVICE - An environmental monitoring device that monitors the operation of a legacy electronic device is described. In particular, a sensor in the environmental monitoring device provides sensor data that represents an environmental condition in an external environment that includes the environmental monitoring device. This environmental condition is associated with the operation of the legacy electronic device in the external environment. The environmental monitoring device analyzes the sensor data and provides feedback about the operation of the legacy electronic device based on the analyzed sensor data. Moreover, the sensor provides the sensor data without or excluding communication and/or electrical coupling between the environmental monitoring device and the legacy electronic device. In this way, the environmental monitoring device facilitates monitoring, analysis and feedback of the sensor data without directly interacting with the legacy electronic device. | 09-18-2014 |
20140278260 | ENVIRONMENTAL MEASUREMENT DISPLAY SYSTEM AND METHOD - Environmental measurement display systems that can be used in home and commercial environments are disclosed. The environmental measurement display system can include an environmental sensor array, signal-processing circuitry, a power supply, a display device, a communications system, a data storage system, and a remote data visualization system. | 09-18-2014 |
20140278735 | ENVIRONMENTAL MONITORING DEVICE - An environmental monitoring device that monitors the operation of a legacy electronic device is described. In particular, a sensor in the environmental monitoring device provides sensor data that represents an environmental condition in an external environment that includes the environmental monitoring device. This environmental condition is associated with the operation of the legacy electronic device in the external environment. The environmental monitoring device analyzes the sensor data and provides feedback about the operation of the legacy electronic device based on the analyzed sensor data. Moreover, the sensor provides the sensor data without or excluding communication and/or electrical coupling between the environmental monitoring device and the legacy electronic device. In this way, the environmental monitoring device facilitates monitoring, analysis and feedback of the sensor data without directly interacting with the legacy electronic device. | 09-18-2014 |
20140279574 | ENVIRONMENTAL MEASUREMENT DISPLAY SYSTEM AND METHOD - Environmental measurement display systems that can be used in home and commercial environments are disclosed. The environmental measurement display system can include an environmental sensor array, signal-processing circuitry, a power supply, a display device, a communications system, a data storage system, and a remote data visualization system. | 09-18-2014 |
20140281479 | ENVIRONMENTAL MEASUREMENT DISPLAY SYSTEM AND METHOD - Environmental measurement display systems that can be used in home and commercial environments are disclosed. The environmental measurement display system can include an environmental sensor array, signal-processing circuitry, a power supply, a display device, a communications system, a data storage system, and a remote data visualization system. | 09-18-2014 |
20140283144 | ENVIRONMENTAL MONITORING DEVICE - An environmental monitoring device that monitors the operation of a legacy electronic device is described. In particular, a sensor in the environmental monitoring device provides sensor data that represents an environmental condition in an external environment that includes the environmental monitoring device. This environmental condition is associated with the operation of the legacy electronic device in the external environment. The environmental monitoring device analyzes the sensor data and provides feedback about the operation of the legacy electronic device based on the analyzed sensor data. Moreover, the sensor provides the sensor data without or excluding communication and/or electrical coupling between the environmental monitoring device and the legacy electronic device. In this way, the environmental monitoring device facilitates monitoring, analysis and feedback of the sensor data without directly interacting with the legacy electronic device. | 09-18-2014 |
20150020615 | ELECTRONIC DEVICE WITH ENVIRONMENTAL MONITORING - An environmental monitoring device that includes an imaging device is described. During operation of the environmental monitoring device, the imaging device provides imaging data for an external environment that includes the environmental monitoring device. Moreover, the imaging device has different spatial sensitivity in different regions of the external environment, which defines a field of view of the imaging device. For example, the imaging device may include a lens with a predefined distortion that provides the different spatial sensitivity, such as Fresnel lens. Alternatively, a mechanical stop may provide the different spatial sensitivity. Furthermore, the environmental monitoring device may include an angular adjustment mechanism that, in response to an external force or a control signal from a control mechanism in the environmental monitoring device, selectively rotates about an axis to change an orientation of the field of view. | 01-22-2015 |
20150021108 | ROBOTIC SYSTEM AND METHODS OF USE - A robotic system that can have a body and four flippers is described. Any or all of the flippers can be rotated. The flippers can have self-cleaning tracks. The tracks can be driven or passive. The robotic system can be controlled by, and send audio and/or video to and/or from, a remote operator control module. The methods of using and making the robotic system are also described. | 01-22-2015 |
20150022337 | ELECTRONIC DEVICE WITH ENVIRONMENTAL MONITORING - An environmental monitoring device that includes a sensor mechanism is described. During operation of the environmental monitoring device, the sensor mechanism provides sensor data based on measurements of an environmental condition in an external environment that includes the environmental monitoring device. If the environmental condition indicates a threat, a control mechanism provides an alert based on an alert setting. This alert can be remotely disabled by providing a modified alert setting. In order to prevent accidental disabling of the alert, a separate control command may also be required. When the providing of the alert is disabled, the control mechanism may continue to assess the threat and, if the threat is increasing, may reactivate the providing of the alert. Alternatively, after a time interval, the modified alert setting may automatically revert to the alert setting. | 01-22-2015 |
20150022351 | ELECTRONIC DEVICE WITH ENVIRONMENTAL MONITORING - An environmental monitoring device that includes an acoustic sensor is described. During operation of the environmental monitoring device, the acoustic sensor provides acoustic data based on measurements of sound in an external environment that includes the environmental monitoring device. Based on the acoustic data, a control mechanism determines if an alarm device, which is separate from the environmental monitoring device, is activated. For example, the environmental monitoring device may determine if a smoke detector is activated based on measurements of sound, such as a temporal 3 acoustic pattern. In addition, a sensor mechanism in the environmental monitoring device may provide sensor data based on measurements of an environmental condition in the external environment. The control mechanism may use the sensor data to assess a degree of threat in the external environment, and the environmental monitoring device may output different audible sounds as the degree of threat changes. | 01-22-2015 |
20150022352 | ELECTRONIC DEVICE WITH ENVIRONMENTAL MONITORING - An environmental monitoring device that includes an acoustic sensor is described. During operation of the environmental monitoring device, the acoustic sensor provides acoustic data based on measurements of sound in an external environment that includes the environmental monitoring device. Based on the acoustic data and predefined characterization of the external environment, a control mechanism determines if an alarm device, which is separate from the environmental monitoring device, is activated. For example, the predefined characterization may include a location of the alarm device. This location may be specified by: an image of the external environment, a positioning system, a communication network, and/or an acoustic latency in the external environment. Alternatively, the predefined characterization may include an acoustic transfer function of the external environment proximate to the alarm device and the environmental monitoring device. Furthermore, if the alarm device is activated, the environmental monitoring device may provide an alert. | 01-22-2015 |
20150067888 | ENVIRONMENTAL MONITORING DEVICE - An environmental monitoring device that monitors the operation of a legacy electronic device is described. In particular, a sensor in the environmental monitoring device provides sensor data that represents an environmental condition in an external environment that includes the environmental monitoring device. This environmental condition is associated with the operation of the legacy electronic device in the external environment. The environmental monitoring device analyzes the sensor data and provides feedback about the operation of the legacy electronic device based on the analyzed sensor data. Moreover, the sensor provides the sensor data without or excluding communication and/or electrical coupling between the environmental monitoring device and the legacy electronic device. In this way, the environmental monitoring device facilitates monitoring, analysis and feedback of the sensor data without directly interacting with the legacy electronic device. | 03-05-2015 |
Andrew G. Stevens, San Francisco, CA US
Patent application number | Description | Published |
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20110240382 | ROBOTIC SYSTEM AND METHOD OF USE - A robotic system that can have a body and four flippers is described. Any or all of the flippers can be rotated. The flippers can have self-cleaning tracks. The tracks can be driven or passive. The robotic system can be controlled by, and send audio and/or video to and/or from, a remote operator control module. The methods of using and making the robotic system are also described. | 10-06-2011 |
20110240383 | ROBOTIC SYSTEM AND METHOD OF USE - A robotic system that can have a body and four flippers is described. Any or all of the flippers can be rotated. The flippers can have self-cleaning tracks. The tracks can be driven or passive. The robotic system can be controlled by, and send audio and/or video to and/or from, a remote operator control module. The methods of using and making the robotic system are also described. | 10-06-2011 |
20120175173 | ROBOTIC SYSTEM AND METHOD OF USE - A robotic system that can have a body and four flippers is described. Any or all of the flippers can be rotated. The flippers can have self-cleaning tracks. The tracks can be driven or passive. The robotic system can be controlled by, and send audio and/or video to and/or from, a remote operator control module. The methods of using and making the robotic system are also described. | 07-12-2012 |
Anthony Stevens, San Francisco, CA US
Patent application number | Description | Published |
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20120210253 | UNIFIED ACCESS AND MANAGEMENT OF EVENTS ACROSS MULTIPLE APPLICATIONS AND ASSOCIATED CONTACTS THEREOF - Systems and methods for unified access and management of events across multiple applications and the associated contacts thereof are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, for enabling multi-application access of associated events via a single interface, including, depicting in the single interface on a device, representations of multiple applications available for access at the device where the single interface is further populated with the events associated with the multiple applications. One embodiment further includes, updating the single interface to visually depict recent events received content from the multiple applications where each of the representations in the single interface, are selectable or actionable to access application features of a corresponding application in a different interface. | 08-16-2012 |
Anthony Stevens, San Diego, CA US
Patent application number | Description | Published |
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20120203661 | E-COMMERCE SYSTEMS AND METHODS - The invention is in general directed to methods and processes for generating revenue via an electronic commerce website. The invention is also directed to methods of processing product orders and selling product related to protocols, workflows, or other applications. The invention also contemplates methods for selling products, which include previously ordered products, related products, substitute products, and equivalent products, including but not limited to equivalent protocol products, matched reagent sets, kits, and biomodules for practicing said protocols and equivalent protocols. | 08-09-2012 |
20130102538 | METHOD OF TREATING ALZHEIMER'S DISEASE USING PHARMACOLOGICAL CHAPERONES TO INCREASE PRESENILIN FUNCTION AND GAMMA-SECRETASE ACTIVITY - The present invention relates to a method for treating an individual having Alzheimer's Disease by using pharmacological chaperones that bind presenelin and thereby increase γ-secretase activity. | 04-25-2013 |
Beth A. Stevens, Palo Alto, CA US
Patent application number | Description | Published |
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20120195880 | Modulation of Synaptic Maintenance - C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including Alzheimer's disease. | 08-02-2012 |
20120328601 | Modulation of Synaptic Maintenance - C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including treating and preventing neurodegenerative diseases such as Alzheimer's disease. | 12-27-2012 |
Bruce E. Stevens, Laguna Niguel, CA US
Patent application number | Description | Published |
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20120191136 | METHOD AND APPARATUS FOR SPINAL FIXATION - Disclosed is a fixation device for spinal fixation. The fixation device includes an elongated body comprising a bone anchor at a distal end. An axially moveable proximal anchor is carried by the proximal end of the fixation device. In one embodiment, the device is inserted through a first vertebra and the bone anchor is rotated into positioned within a second vertebra. The proximal anchor is distally advanced with respect to the bone anchor to provide compression across the first and second vertebra. In other embodiments, the device is used to secure stabilization devices across two or more vertebra. | 07-26-2012 |
Charles F. Stevens, La Jolla, CA US
Patent application number | Description | Published |
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20120221076 | CUSTOMIZATION OF IRREGULAR ARRAYS - An apparatus includes: an input configured to receive information indicative of sensed light locations; memory coupled to the input and storing indicia of receptive fields forming a mosaic, each of the receptive fields corresponding to an electrode, the mosaic including first and receptive fields having first and second shapes that are different, the memory further storing instructions; a processor coupled to the input and the memory and configured to read and execute the instructions to: analyze the information indicative of sensed light locations; determine, for each of respective ones of the sensed light locations, one or more receptive fields that include the corresponding sensed light location; and produce excitation indicia; the apparatus further including an output coupled to the processor and configured to be coupled to a retinal implant and to convey the excitation indicia toward the retinal implant. | 08-30-2012 |
Charles G. Stevens, Danville, CA US
Patent application number | Description | Published |
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20110240861 | ROOM-TEMPERATURE QUANTUM NOISE LIMITED SPECTROMETRY AND METHODS OF THE SAME - In one embodiment, a heterodyne detection system for detecting light includes a first input aperture adapted for receiving first light from a scene input, a second input aperture adapted for receiving second light from a local oscillator input, a broadband local oscillator adapted for providing the second light to the second input aperture, a dispersive element adapted for dispersing the first light and the second light, and a final condensing lens coupled to an infrared detector. The final condensing lens is adapted for concentrating incident light from a primary condensing lens onto the infrared detector, and the infrared detector is a square-law detector capable of sensing the frequency difference between the first light and the second light. More systems and methods for detecting light are described according to other embodiments. | 10-06-2011 |
20110242527 | ROOM-TEMPERATURE QUANTUM NOISE LIMITED SPECTROMETRY AND METHODS OF THE SAME - In one embodiment, a heterodyne detection system for detecting light includes a first input aperture adapted for receiving a first light from a scene input, a second input aperture adapted for receiving a second light from a local oscillator input, a broadband local oscillator adapted for providing the second light to the second input aperture, a dispersive element adapted for dispersing the first light and the second light, and a final condensing lens coupled to an infrared detector. The final condensing lens is adapted for concentrating incident light from a primary condensing lens onto the detector, and the detector is a square-law detector capable of sensing the frequency difference between the first light and the second light. More systems and methods for detecting light are disclosed according to more embodiments. | 10-06-2011 |
20140326884 | ROOM-TEMPERATURE QUANTUM NOISE LIMITED SPECTROMETRY AND METHODS OF THE SAME - In one embodiment, a heterodyne detection system for detecting light includes a first input aperture configured to receive first light from a scene input, a second input aperture configured to receive second light from a local oscillator input, a broadband local oscillator configured to provide the second light to the second input aperture, a dispersive element configured to disperse the first light and the second light, and a final condensing lens coupled to an infrared detector. The final condensing lens is configured to concentrate incident light from a primary condensing lens onto the infrared detector, and the infrared detector is a square-law detector capable of sensing the frequency difference between the first light and the second light. More systems and methods for detecting light are described according to other embodiments. | 11-06-2014 |
Craig Lyle Stevens, Ben Lomond, CA US
Patent application number | Description | Published |
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20110142572 | AUTO-SEQUENCING INLINE PROCESSING APPARATUS - An apparatus and method for concurrent processing of several substrates. The system employs a novel architecture which, while being linear, may autonomously sequence processing and move substrates in different directions as necessary. The system moves several substrates concurrently; however, unlike the prior art it does not utilize trays. | 06-16-2011 |
20110142573 | AUTO-SEQUENCING MULTI-DIRECTIONAL INLINE PROCESSING APPARATUS - An apparatus and method for concurrent processing of several substrates. The system employs a novel architecture which, while being linear, may autonomously sequence processing and move substrates in different directions as necessary. The system moves several substrates concurrently; however, unlike the prior art it does not utilize trays. | 06-16-2011 |
20120267049 | GROUNDING ASSEMBLY FOR VACUUM PROCESSING APPARATUS - Vacuum processing chambers having provisions for improved electrical contact to substrate carrier. Specific embodiments provide a plasma processing chamber having a pedestal for supporting the carrier, and a plurality of fixed posts and resilient contacts are distributed over the area of the pedestal. The fixed posts provide physical support for the carrier, while the resilient contacts provide reliable and repeatable multi-point electrical contact to the carrier. | 10-25-2012 |
20120298141 | BROKEN WAFER RECOVERY SYSTEM - An apparatus and method for recovery and cleaning of broken substrates, especially beneficial for fabrication systems using silicon wafer carried on trays. Removal of broken wafers and particles from within the fabrication system is enabled without requiring disassembly of the system and without requiring manual labor. | 11-29-2012 |
20130269149 | BROKEN WAFER RECOVERY SYSTEM - An apparatus and method for recovery and cleaning of broken substrates, especially beneficial for fabrication systems using silicon wafer carried on trays. Removal of broken wafers and particles from within the fabrication system is enabled without requiring disassembly of the system and without requiring manual labor. A placing mechanism moves a suction head to location of the broken substrate and a suction pump coupled to a flexible hose is used to remove the broken pieces. A hood is positioned at the inlet of the suction head, and setback extensions are provided at the bottom of the hood to allow air flow into the inlet and prevent thermal conductance from the tray to the hood. Pins are extendable about the inlet of the suction head to enable breakage of the wafer to smaller pieces for easy removal. | 10-17-2013 |
20130294678 | AUTO-SEQUENCING MULTI-DIRECTIONAL INLINE PROCESSING METHOD - A method for auto-sequencing of plasma processing system for concurrent processing of several substrates. The method autonomously sequence processing and move substrates in different directions as necessary. The method moves two substrate trays together into the processing chamber for substrate exchange, and remove the trays from the chamber one at a time. When needed, the method moves one tray into the processing chamber for removal of the susceptor without exposing the chamber to atmospheric environment. | 11-07-2013 |
Curtis Stevens, Santa Clara, CA US
Patent application number | Description | Published |
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20100027769 | GLOBAL TELECOMMUNICATIONS NETWORK PROACTIVE REPOSITORY, WITH COMMUNICATION NETWORK OVERLOAD MANAGEMENT - A proactive repository stores authenticated information regarding Entities and their properties. A set of conditions and policies is associated with the information in the repository. These conditions govern the release of information to an authorized recipient. Release conditions include various forms of activation, such as activation of emergency services dispatch, a change in condition of a public utility, a change in geophysical or meteorological conditions, etc. At least one responsible third party can authenticate Entities, agents agencies and the like, validate associated credentials, and store received information in the repository. A first proactive repository can be stored within a second proactive repository. A proactive repository can provide the facilities of a multi-modal notification delivery system. | 02-04-2010 |
Curtis E. Stevens, Irvine, CA US
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20100146203 | USING NATIVE COMMAND QUEUING TAGS TO IMPLEMENT PROTECTION INFORMATION FOR DISK DRIVES - A disk drive is disclosed comprising a disk and a head actuated over the disk. The disk drive further comprises control circuitry operable to receive a Native Command Queuing (NCQ) access command from a host, wherein the NCQ access command comprises at least one logical block address (LBA), and a tag field for identifying the access command. The tag field is evaluated to determine a size of the logical block in order to transfer the logical block between the disk drive and the host. In one embodiment, the tag field comprises a tag number selected from a range of numbers, including a first range of numbers identifying a first logical block size, and a second range of numbers identifying a second logical block size. | 06-10-2010 |
20110154112 | DATA STORAGE DEVICE TESTER - A data storage device (DSD) tester is disclosed for testing a DSD. The DSD tester comprises control circuitry operable to receive production line data through an interface, wherein the production line data is related to the DSD. The control circuitry executes a DSD test on the DSD, and transmits failure data generated by the DSD test and the production line data to a failure information database. | 06-23-2011 |
20110154113 | DATA STORAGE DEVICE TESTER - A data storage device (DSD) tester for testing a DSD is disclosed. The DSD tester comprises control circuitry operable to receive a DSD log from the DSD, wherein the DSD log comprises at least one entry identifying at least one error condition. A sequence of commands associated with the error condition is executed in order to determine whether the DSD is defective. | 06-23-2011 |
20110271151 | METHOD FOR PROVIDING ASYNCHRONOUS EVENT NOTIFICATION IN SYSTEMS - A method is provided for asynchronous notifications from a device to a host in systems without requiring hardware provision for asynchronous operations. In an embodiment of the invention, a system supports command queuing and a command is sent from a host to a device. The device receives the command and an associated tag, and accepts the command as valid. After accepting the command, the device begins monitoring for asynchronous events. If an asynchronous event is detected, the device provides notification of the event by sending a response and the associated tag to the host. In another embodiment of the invention, a method of asynchronous notification enables use of invalid tags. In a further embodiment of the invention, asynchronous notifications may be enabled by a host and operate without additional host commands. | 11-03-2011 |
Daniel M. Stevens, Cardiff, CA US
Patent application number | Description | Published |
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20100120551 | INTERCHANGEABLE SHAFT FOR A GOLF CLUB - A golf club ( | 05-13-2010 |
20100177298 | LASER RANGE FINDER FOR USE ON A GOLF COURSE - An improved range finder for use on a golf course. The improved range finder includes means for identifying the closest target in a field of view during a sweep operation of the field of view and means for presenting the distance of the closest target at the conclusion of the sweep operation of the field of view. The improved range finder preferably uses infrared light to detect a flagstick. | 07-15-2010 |
20100216569 | GOLF CLUB WITH HIGH MOMENT OF INERTIA - A golf club ( | 08-26-2010 |
20100323811 | HYBRID GOLF CLUB HEAD - A hybrid type golf club head is disclosed herein. The hybrid golf club head preferably has an increased heel/toe camber to minimize drag through rough when a golfer swings the hybrid golf club. A sole of the hybrid golf club head is relieved to allow for the face angle to open without the leading edge lifting too high. | 12-23-2010 |
20110070969 | HYBRID GOLF CLUB HEAD - A hybrid type golf club head is disclosed herein. The hybrid golf club head preferably has an exterior heel weight, an exterior toe weight, and interior sole weight and a stainless steel body. The hybrid golf club head preferably has a moment of inertia Ixx about a center of gravity ranging from 2100 to 2300 grams-centimeters squared. | 03-24-2011 |
20110118047 | INTGERCHANGEABLE SHAFT FOR A GOLF CLUB - A golf club ( | 05-19-2011 |
20110275449 | INTERCHANGEABLE SHAFT FOR A GOLF CLUB - A golf club ( | 11-10-2011 |
20110306437 | INTERCHANGEABLE SHAFT FOR A GOLF CLUB - A golf club ( | 12-15-2011 |
20110312434 | INTERCHANGEABLE SHAFT FOR A GOLF CLUB - A golf club ( | 12-22-2011 |
20120064990 | INTERCHANGEABLE SHAFT FOR A GOLF CLUB - A golf club ( | 03-15-2012 |
Daniel M. Stevens, Carlsbad, CA US
Patent application number | Description | Published |
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20090275419 | Golf Club With High Moment Of Inertia - A golf club ( | 11-05-2009 |
Darla Stevens, Lancaster, CA US
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20100184354 | TOY HOUSE - Disclosed is a toy house for storing and displaying at least one toy. The toy house includes a body portion, a door and a name plate. The body portion is configured to define an interior space for storing the at least one toy. The door is hingedly connected to the body portion and is configured to provide access to the interior space. The door includes a door closing mechanism for facilitating opening and closing of the door. The name plate is removably disposed on at least one of the body portion and the door. Further, the name plate includes at least one indicium configured thereon. | 07-22-2010 |
David A. Stevens, Saratoga, CA US
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20080220023 | ANTIFUNGAL VACCINES WITH SACCHAROMYCES CEREVISIAE - Methods and formulations for vaccinating induce in mammals that are vaccinated protective immunity against diseases caused by fungi. The vaccines include a yeast, such as | 09-11-2008 |
20080220024 | ANTIFUNGAL VACCINES WITH SACCHAROMYCES CEREVISIAE - Methods and formulations for vaccinating induce in mammals that are vaccinated protective immunity against diseases caused by fungi. The vaccines include a yeast, such as | 09-11-2008 |
David Richard Stevens, San Jose, CA US
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20080302252 | Portable Brewing Device and Method of Making and Operating - A portable brewing device is provided for brewing a hot beverage such as espresso that includes a compressed gas container communicating with a pressure regulator that is configured to control the pressure of gas released from the compressed gas container. A release switch is configured to communicate with pressure regulator and configured to release pressure controlled gas when actuated by a user. A water vessel is configured to receive the pressure controlled gas when the switch is actuated by a user. A mixing vessel can hold a brew substance and is configured to communicate with the water vessel and also configured to receive water from the water vessel to pass through the brew substance when pressure is released from the gas container through the pressure regulator. An outlet is configured to release a brewed product produced from water flowing through the brew substance contained in the mixing vessel when brewing. | 12-11-2008 |
Eli Stevens, Santa Clara, CA US
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20100058165 | METHOD AND SYSTEM FOR DISPLAYING NETWORK SECURITY INCIDENTS - A network security monitor system groups a plurality of security events into network sessions, correlates the network sessions according to a set of predefined network security event correlation rules and generates a security incident for the network sessions that satisfy one of the network security event correlation rules. The system then presents the information of the network sessions and security incidents to a user of the system in an intuitive form. The user is able to not only learn the details of a possible network attack, but also creates new security event correlation rules intuitively, including drop rules for dropping a particular type of events. | 03-04-2010 |
Gary L. Stevens, Glendora, CA US
Patent application number | Description | Published |
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20090122169 | HIGHLY MINIATURIZED, BATTERY OPERATED, DIGITAL WIRELESS CAMERA USING PROGRAMMABLE SINGLE CHIP ACTIVE PIXEL SENSOR (APS) DIGITAL CAMERA CHIP - A miniaturized camera which is programmable and provides low power consumption. An active pixel image sensor used in the highly miniaturized camera provides improved imaging functionality as well as reduced power consumption, extending the possible life time of the camera system. The spread spectrum nature of transmission and reception improves data integrity as well as data security. The ability of the highly miniaturized wireless camera to receive commands as well as transmit image data provides improved functionality and a variable rate of power consumption to be set according to the application and needs of the situation. | 05-14-2009 |
Greg Louis Stevens, Scotts Valley, CA US
Patent application number | Description | Published |
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20110093656 | SYSTEMS, METHODS, AND COMPUTER READABLE MEDIA FOR CONFIGURING A REWRITEABLE NON-VOLATILE MEMORY FOR PRESENTATION OF MEDIA BY A SELECTED MEDIA PRESENTATION DEVICE MODEL - Systems, methods, and computer readable media for managing digital media in a memory storage device associated with a mobile smart device are disclosed. According to one aspect, the subject matter described herein includes a method for configuring a rewriteable non-volatile memory for presentation of media by a selected media presentation device model. The method includes providing a rewriteable non-volatile memory configuration interface through which a user can select at least one media file and one of a plurality of media presentation device models. and providing a rewriteable non-volatile memory configuration manager, which, in response to selection of the at least one media file and the one media presentation device model via the configuration interface, accesses a database including entries corresponding to the plurality of media presentation device models and configures a rewriteable non-volatile memory according to information retrieved from the database to allow presentation of the at least one media file when the rewriteable non-volatile memory is present in the selected media presentation device model. | 04-21-2011 |
Jed Stevens, Mission Viejo, CA US
Patent application number | Description | Published |
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20110051140 | FULL-FLOW SENSOR FOR CONTAMINATION IN FLUIDS - A sensing system includes a housing having an inlet for receiving a fluid flow from a source and an outlet with for directing a fluid flow from the housing, wherein a longitudinal axis transverses a center of the inlet and the outlet; a flow conduit disposed in the housing and in fluid communication with the inlet and the outlet, the flow conduit having a cross-sectional area that is substantially the same as a cross-sectional area of the inlet and the outlet, wherein a first length of the flow conduit along a second axis, and wherein the first axis and the second axis are perpendicular to the longitudinal axis; a light source for illuminating the fluid in the flow conduit along the first axis; and a sensor for detecting contaminants in the fluid. | 03-03-2011 |
Jed Babbington Stevens, Mission Viejo, CA US
Patent application number | Description | Published |
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20110154242 | FLOW DIFFERENTIAL PRESSURE MODULE - A pressure module for a transient fluid includes a circuit board having a means for processing data, a flow meter input in data communication with the circuit board to receive a flow data representing at least a flow rate of the fluid, and a pressure sensor input in data communication with the circuit board to receive a pressure data representing at least a differential pressure of the fluid, wherein the circuit board processes data from at least one of the flow meter and the pressure sensor to calculate a corrected differential pressure. | 06-23-2011 |
20110187392 | FLOW METER - A flow meter includes a main body having a first end and a second end, a flexible electrical resistor coupled to the main body and extending outwardly from the second end thereof, wherein an electrical resistance of the flexible electrical resistor varies in response to a flexure thereof, and an electrical circuit in electrical communication with the electrical resistor to detect a flexure of the electrical resistor. | 08-04-2011 |
Jeffrey Stevens, Cupertino, CA US
Patent application number | Description | Published |
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20100027769 | GLOBAL TELECOMMUNICATIONS NETWORK PROACTIVE REPOSITORY, WITH COMMUNICATION NETWORK OVERLOAD MANAGEMENT - A proactive repository stores authenticated information regarding Entities and their properties. A set of conditions and policies is associated with the information in the repository. These conditions govern the release of information to an authorized recipient. Release conditions include various forms of activation, such as activation of emergency services dispatch, a change in condition of a public utility, a change in geophysical or meteorological conditions, etc. At least one responsible third party can authenticate Entities, agents agencies and the like, validate associated credentials, and store received information in the repository. A first proactive repository can be stored within a second proactive repository. A proactive repository can provide the facilities of a multi-modal notification delivery system. | 02-04-2010 |
Jennitte Stevens, Ventura, CA US
Patent application number | Description | Published |
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20120328616 | HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO A COMPLEX COMPRISING BETA-KLOTHO AND AN FGF RECEPTOR - The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. | 12-27-2012 |
John Stevens, Porter Ranch, CA US
Patent application number | Description | Published |
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20100109711 | LOW NOISE CORRELATED DOUBLE SAMPLING AMPLIFIER FOR 4T TECHNOLOGY - A correlated double sampling circuit and method for providing the same are disclosed. The circuit may include an amplifier, a plurality of capacitors, and a switch matrix. The amplifier provides a reset voltage replica and a signal voltage replica. The switch matrix controls a plurality of switches to perform correlated double sampling over at least three phases. The first phase for sampling the reset voltage replica on a first and second capacitors. The second phase for sampling the reset voltage replica and the kTC noise on a third capacitor. The first phase producing a thermal kTC noise from the first and second capacitors. The third phase for subtracting a charge representing the signal voltage replica, the kTC noise and the reset voltage replica, combined, from the charge sampled in the second phase to provide an output voltage. The method for providing low noise correlated double sampling includes controlling the plurality of switches to provide the at least three phases. | 05-06-2010 |
John H. Stevens, Palo Alto, CA US
Patent application number | Description | Published |
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20110270388 | Endovascular aortic valve replacement - The subject invention relates to a valve replacement system together with methods of preparation and use, are provided for endovascular replacement of a heart valve in a host. The valve replacement system includes up to five components: (1) a prosthetic valve device, (2) a valve introducer device, (3) an intraluminal procedure device, (4) a procedure device capsule, and (5) a tissue cutter. The system provides for endovascular removal of a malfunctioning valve and subsequent replacement with a permanent prosthetic heart valve. | 11-03-2011 |
20140046642 | METHOD AND SYSTEM FOR PROVIDING INFORMATION FROM A PATIENT-SPECIFIC MODEL OF BLOOD FLOW - Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location. | 02-13-2014 |
20140164969 | METHOD AND SYSTEM FOR PROVIDING INFORMATION FROM A PATIENT-SPECIFIC MODEL OF BLOOD FLOW - Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location. | 06-12-2014 |
20140173486 | METHOD AND SYSTEM FOR PROVIDING INFORMATION FROM A PATIENT-SPECIFIC MODEL OF BLOOD FLOW - Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location. | 06-19-2014 |
20140236553 | METHOD AND SYSTEM FOR PROVIDING INFORMATION FROM A PATIENT-SPECIFIC MODEL OF BLOOD FLOW - Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location. | 08-21-2014 |
20140292752 | METHOD AND SYSTEM FOR PROVIDING INFORMATION FROM A PATIENT-SPECIFIC MODEL OF BLOOD FLOW - Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location. | 10-02-2014 |
20140350908 | METHOD AND SYSTEM FOR PROVIDING INFORMATION FROM A PATIENT-SPECIFIC MODEL OF BLOOD FLOW - Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location. | 11-27-2014 |
20150073761 | METHOD AND SYSTEM FOR PROVIDING INFORMATION FROM A PATIENT-SPECIFIC MODEL OF BLOOD FLOW - Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location. | 03-12-2015 |
20150073766 | METHOD AND SYSTEM FOR PROVIDING INFORMATION FROM A PATIENT-SPECIFIC MODEL OF BLOOD FLOW - Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location. | 03-12-2015 |
20150073767 | METHOD AND SYSTEM FOR PROVIDING INFORMATION FROM A PATIENT-SPECIFIC MODEL OF BLOOD FLOW - Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location. | 03-12-2015 |
20150074610 | METHOD AND SYSTEM FOR PROVIDING INFORMATION FROM A PATIENT-SPECIFIC MODEL OF BLOOD FLOW - Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location. | 03-12-2015 |
John C. Stevens, Northridge, CA US
Patent application number | Description | Published |
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20090090846 | Imaging system with low noise pixel array column buffer - An imaging system includes a row and column array of active pixels, each having an associated pitch. In response to respective control signals, each pixel outputs a reset level which includes noise components, or a signal level which includes signal and noise components. Multiple column buffers, each having a pitch equal to or less than that of a pixel, convey the outputs of respective pixel columns to a bus line. Each buffer comprises ‘odd’ and ‘even’ S&H/CDS circuits, which process the pixel outputs of odd and even rows, respectively. Each S&H/CDS circuit subtracts pixel reset level from signal level to produce an output in which correlated noise is suppressed. Each column buffer includes a buffer amplifier which conveys the output to the bus line. A gain amplifier separate from the column buffers is coupled to the bus line such that it amplifies the outputs of a multiple column buffers. | 04-09-2009 |
John C. Stevens, Porter Ranch, CA US
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20100123504 | ADAPTIVE LOW NOISE OFFSET SUBTRACTION FOR IMAGERS WITH LONG INTEGRATION TIMES - An adaptive low noise offset subtraction pixel and method for adaptive low noise offset subtraction is disclosed. The pixel has a photosensitive element, a current offset memorization circuit and a current subtraction circuit. The current subtraction circuit coupled to the current offset memorization circuit, and comprises a transistor selected from a group consisting of a junction gate field-effect transistor, a bipolar transistor, a MOSFET transistor with a spiral channel, and a MOSFET transistor with a buried channel. The transistor configured to receive an offset current from the current offset memorization circuit and subtract the offset current from an output signal current received from the photosensitive element to provide an offset-free signal current and a shot noise limited subtraction current. | 05-20-2010 |
John Henry Stevens, Palo Alto, CA US
Patent application number | Description | Published |
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20090313886 | VARIOUS METHODS AND APPARATUS FOR SOLAR ASSISTED CHEMICAL AND ENERGY PROCESSES - A method, apparatus, and system are described in which products from a solar assisted Reverse Water Gas Shift (RWGS) reaction are used in a hydrocarbon fuel synthesis process to create a liquid hydrocarbon fuel. A water splitter splits water molecules into hydrogen and oxygen via the addition of the solar energy. A chemical reactor chamber mixes solar heated carbon dioxide gas with all or just a portion of the hydrogen molecules from the water splitter in a RWGS reaction to produce resultant carbon monoxide. A hydrocarbon liquid fuel synthesis reactor receives and uses either 1) all of the unconsumed portions of hydrogen from the RWGS or 2) the remaining portion of the hydrogen molecules from the water splitter and the resultant carbon monoxide molecules from the RWGS in the hydrocarbon fuel synthesis process to create a liquid hydrocarbon fuel. | 12-24-2009 |
20100000874 | VARIOUS METHODS AND APPARATUS FOR SOLAR ASSISTED FUEL PRODUCTION - Products from a solar assisted reverse-water-gas-shift reaction (RWGS) are used to create a liquid hydrocarbon fuel. Heliostats focus solar energy to heat carbon dioxide gas. A water splitter splits water into hydrogen molecules and oxygen molecules via the addition of the solar energy also directed from either the same array of heliostats via a beam splitter off a common receiving tower redirecting a portion of the electromagnetic spectrum, a heliostat field dedicated for the water splitter, or from its own parabolic trough. A chemical reactor mixes heated carbon dioxide gas with all or just a portion of the hydrogen molecules from the water splitter in a RWGS reaction to produce resultant carbon monoxide. A synthesis reactor uses any unconsumed hydrogen molecules and the resultant stabilized carbon monoxide molecules from the RWGS reaction in the hydrocarbon fuel synthesis process to create a liquid hydrocarbon fuel. | 01-07-2010 |
John R. Stevens, San Francisco, CA US
Patent application number | Description | Published |
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20080243559 | WORKERS' COMPENSATION INFORMATION PROCESSING SYSTEM - A workers' compensation medical reporting system including software accessed at a provider computer, the software adapted to prompt the provider to input the data concerning a workers' compensation claim, the software adapted to send an electronic workers' compensation claim, the software adapted to send an electronic workers' compensation treatment report electronically across the Internet to a payer computer; and electronic report filtering software accessed at the payer computer, the electronic report filtering software adapted to direct the electronic report as a result of predetermined criteria, electronic workers' compensation medical treatment reports that meet a human review criteria are automatically set to a case manager for review, other electronic workers' compensation medical treatment reports are automatically directed to be processed. | 10-02-2008 |
Joseph O. Stevens, San Diego, CA US
Patent application number | Description | Published |
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20120070233 | FOUNDATION FOR WIND TURBINE GENERATOR - A base for holding a wind turbine tower is disclosed. The base includes individual shaft piles, a base cap and anchoring units. The base cap includes reinforcement inserts and is connected to each of the individual shaft piles. The anchoring units are embedded in the base cap and extend in an anchoring direction from the base cap at anchoring locations for anchoring the wind turbine tower to the base cap. Each of the reinforcement inserts extend in a radial direction relative to a center axis of the wind turbine tower. At least one of the plurality of reinforcement inserts, at a radius of the center axis adjacent to an anchoring location of a respective anchoring unit, has a portion of the respective reinforcement insert extending along the anchoring direction. | 03-22-2012 |
Julian Stevens, Sunnyvale, CA US
Patent application number | Description | Published |
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20140276676 | LASER CAPSULOVITREOTOMY - Methods and systems for performing laser-assisted surgery on an eye form a layer of bubbles in the Berger's space of the eye to increase separation between the posterior portion of the lens capsule of the eye and the anterior hyaloid surface of the eye. A laser is used to form the layer of bubbles in the Berger's space. The increased separation between the posterior portion of the lens capsule and the anterior hyaloid surface can be used to facilitate subsequent incision of the posterior portion of the lens capsule with decreased risk of compromising the anterior hyaloid surface. For example, the layer of bubbles can be formed prior to performing a capsulotomy on the posterior portion of the lens capsule. | 09-18-2014 |
20140276681 | MICROFEMTOTOMY METHODS AND SYSTEMS - Methods and systems for performing laser-assisted surgery on an eye form one or more small anchoring capsulotomies in the lens capsule of the eye. The one or more anchoring capsulotomies are configured to accommodate corresponding anchoring features of an intraocular lens and/or to accommodate one or more drug-eluting members. A method for performing laser-assisted eye surgery on an eye having a lens capsule includes forming an anchoring capsulotomy in the lens capsule and coupling an anchoring feature of the intraocular lens with the anchoring capsulotomy. The anchoring capsulotomy is formed by using a laser to incise the lens capsule. The anchoring feature can protrude transverse to a surface of the intraocular lens that interfaces with the lens capsule adjacent to the anchoring capsulotomy. | 09-18-2014 |
Junko Stevens, Menlo Park, CA US
Patent application number | Description | Published |
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20080228589 | Methods For Placing, Accepting, And Filling Orders For Products and Services - Methods and systems for ordering assays which detect SNPs or gene expression are provided. The methods use PCR and RT-PCR procedures. Collections of stock assays are assembled using pre- and post-manufacturing quality control procedures and made available to consumers via the Internet. In addition, custom assays are prepared upon order from the consumer and these assays are also prepared using pre- and post-manufacturing quality control procedures. The assays are then delivered to the consumer. | 09-18-2008 |
20090239233 | SINGLE-TUBE, READY-TO-USE ASSAY KITS, AND METHODS USING SAME - An assay kit is provided that includes assay reagents stored in a single-tube container, and a data storage medium containing information about the contents of the container. Methods are provided for using the data provided with the kit to direct instruments and/or processes, for example, to control an instrument to perform amplification and/or sequencing reactions. | 09-24-2009 |
20090239290 | SINGLE-TUBE, READY-TO-USE ASSAY KITS, AND METHODS USING SAME - An assay kit is provided that includes assay reagents stored in a single-tube container, and a data storage medium containing information about the contents of the container. Methods are provided for using the data provided with the kit to direct instruments and/or processes, for example, to control an instrument to perform amplification and/or sequencing reactions. | 09-24-2009 |
20100203525 | DETECTION OF GENE DUPLICATIONS - Methods of detecting a candidate genetic anomaly such as a candidate duplication in a genome are disclosed. The methods comprise quantifying fluorogenic assays for alleles of a genetic locus from a plurality of individual genomes, identifying ranges of fluorescent intensities indicative of individual genomes homozygous for a first allele, homozygous for a second allele, or heterozygous for both alleles, and identifying individual genomes in which the fluorescence intensities are outside the range of intensities indicative of homozygosity or heterozygosity for the genetic locus. | 08-12-2010 |
20110262898 | Compositions, Methods, and Kits for Amplifying Nucleic Acids - The present teachings are directed to compositions, methods, and kits for amplifying target nucleic acids while reducing non-specific fluorescence and undesired amplification products, sometimes referred to as secondary amplification products or spurious side-products. The enzyme inhibitors disclosed herein comprise a nucleotide sequence and at least one quencher. Complexes comprising an enzyme inhibitor associated with an enzyme, wherein at least one enzymatic activity of the enzyme is inhibited, are also provided. Methods for amplifying a target nucleic acid while reducing undesired amplification products are disclosed, as are methods for reducing non-specific fluorescence. Kits for expediting the performance of certain disclosed methods are also provided. | 10-27-2011 |
20120303472 | METHODS FOR PLACING, ACCEPTING, AND FILLING ORDERS FOR PRODUCTS AND SERVICES - Methods and systems for ordering assays which detect SNPs or gene expression are provided. The methods use PCR and RT-PCR procedures. Collections of stock assays are assembled using pre- and post-manufacturing quality control procedures and made available to consumers via the Internet. In addition, custom assays are prepared upon order from the consumer and these assays are also prepared using pre- and post-manufacturing quality control procedures. The assays are then delivered to the consumer. | 11-29-2012 |
20140004515 | COMPOSITIONS, METHODS, AND KITS FOR AMPLIFYING NUCLEIC ACIDS | 01-02-2014 |
20140099644 | NOVEL COMPOSITIONS, METHODS AND KITS FOR REAL TIME POLYMERASE CHAIN REACTION (PCR) - The present disclosure is directed to compositions, methods and kits for amplifying target nucleic acids while reducing non-specific amplification and undesired amplification products using a dual hot start reaction mixture that comprise at least two different hot start mechanisms. | 04-10-2014 |
20140329238 | DETECTION OF GENE DUPLICATIONS - Methods of detecting a candidate genetic anomaly such as a candidate duplication in a genome are disclosed. The methods comprise quantifying fluorogenic assays for alleles of a genetic locus from a plurality of individual genomes, identifying ranges of fluorescent intensities indicative of individual genomes homozygous for a first allele, homozygous for a second allele, or heterozygous for both alleles, and identifying individual genomes in which the fluorescence intensities are outside the range of intensities indicative of homozygosity or heterozygosity for the genetic locus. | 11-06-2014 |
Junko F. Stevens, Menlo Park, CA US
Patent application number | Description | Published |
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20100041057 | DNA METHYLATION DETECTION METHODS - The present teachings provide DNA methylation quantification methods that avoid bisulfite treatment of DNA. Methylation-specific binding proteins (MeDNA binding proteins) and non-methylation specific binding proteins (non-MeDNA binding proteins) are employed in various embodiments to modulate the accessibility of nucleic acids to primer extension reactions. After selectively removing the target nucleic acids, the extension products can be analyzed and methylation quantitated. In some embodiments, the analysis comprises real-time PCR. | 02-18-2010 |
20120149012 | DNA Methylation Detection Methods - The present teachings provide DNA methylation quantification methods that avoid bisulfite treatment of DNA. Methylation-specific binding proteins (MeDNA binding proteins) and non-methylation specific binding proteins (non-MeDNA binding proteins) are employed in various embodiments to modulate the accessibility of nucleic acids to primer extension reactions. After selectively removing the target nucleic acids, the extension products can be analyzed and methylation quantitated. In some embodiments, the analysis comprises real-time PCR. | 06-14-2012 |
20120302449 | Chromosome Conformation Analysis - Disclosed herein are compositions, methods and kits for analyzing three-dimensional chromatin and/or chromosome conformation. Method are also disclosed for using the methods disclosed herein for diagnosing diseases such as cancer. | 11-29-2012 |
20130084574 | Chromosome Conformation Analysis - Disclosed herein are compositions, methods and kits for analyzing three-dimensional chromatin and/or chromosome conformation. Method are also disclosed for using the methods disclosed herein for diagnosing diseases such as cancer. | 04-04-2013 |
20140221254 | Chromosome Conformation Analysis - Disclosed herein are compositions, methods and kits for analyzing three-dimensional chromatin and/or chromosome conformation. Method are also disclosed for using the methods disclosed herein for diagnosing diseases such as cancer. | 08-07-2014 |
Junko F. Stevens, Menio Park, CA US
Patent application number | Description | Published |
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20100113285 | Normalization of Data Using Controls - A method of using a standard to correct for variability in sample handling, can comprise (a) adding a template of known concentration to an assay comprising a sample; (b) preamplifying the assay; (c) amplifying the assay; (d) collecting data during the amplifying; and (e) correcting the data using a comparison of data collected from the template to data collected from the sample. | 05-06-2010 |
Keith Stevens, Los Angeles, CA US
Patent application number | Description | Published |
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20110009991 | DISTRIBUTION BACKBONE - Digitally distributing media content using a distribution backbone system, including: receiving a request for media content from a client, the request including a client profile; performing inventory and analysis of source assets by iteratively progressing through the client profile to create output; performing a capability mapping in which a series of rules that allow the source assets to be mapped to the client profile; and planning a manufacturing process, which determines work items and execution steps from capabilities mapped in response to the request for media content from the client. | 01-13-2011 |
20130184844 | DISTRIBUTION BACKBONE - Digitally distributing media content using a distribution backbone system, including: receiving a request for media content from a client, the request including a client profile; performing inventory and analysis of source assets by iteratively progressing through the client profile to create output; performing a capability mapping in which a series of rules that allow the source assets to be mapped to the client profile; and planning a manufacturing process, which determines work items and execution steps from capabilities mapped in response to the request for media content from the client. | 07-18-2013 |
Luis Stevens, San Jose, CA US
Patent application number | Description | Published |
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20140297652 | Hierarchical, Parallel Models for Extracting in Real-Time High-Value Information from Data Streams and System and Method for Creation of Same - A computer system identifies high-value information in data streams. The computer system receives a receiving a plurality of data streams. Each of the data streams includes a plurality of posts. Each of the posts includes a content portion and one or more source characteristics, In real time, for each post in a particular data stream: the system assigns the post a post identifier; generates a content packet and one or more source packets; queries memory to access a source profile using a respective source identifier included in the content packet; correlates the content packet with information from the source profile to produce a correlated content packet; and broadcasts the correlated content packet to a plurality of filter graph definitions. | 10-02-2014 |
20140297664 | Hierarchical, Parallel Models for Extracting in Real-Time High-Value Information from Data Streams and System and Method for Creation of Same - A computer system identifies high-value information in data streams. The computer system receives a plurality of filter graph definitions. Each of the filter graph definitions includes a plurality of filter nodes arranged in a two-dimensional graph by a plurality of graph edges. Each filter node is configured to accept or reject individual packets in a data stream based on content and/or metadata information associated with the individual packet. The system prepares the filter graph for execution. In response to receiving a data stream with a plurality of packets, the system distributes the packets to inputs of each of the executable filter graph definitions. The system identifies, using the executable filter graph definitions, packets with high-value information based on parallel execution of the filter nodes included in the respective filter graph definition. | 10-02-2014 |
20140297665 | Optimization for Real-Time, Parallel Execution of Models for Extracting High-Value Information from Data Streams - A computer system identifies high-value information in data streams. The computer system receives a filter graph definition. The filter graph definition includes a plurality of filter nodes, each filter node including one or more filters that accept or reject packets. Each respective filter is categorized by a number of operations, and the one or more filters are arranged in a general graph. The computer system performs one or more optimization operations, including: determining if a closed circuit exists within the graph, and when the closed circuit exists within the graph, removing the closed circuit; reordering the filters based at least in part on the number of operations; and parallelizing the general graph such that the one or more filters are configured to be executed on one or more processors. | 10-02-2014 |
Luis F. Stevens, Milpitas, CA US
Patent application number | Description | Published |
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20090094364 | VIRTUALIZATION METHOD AND APPARATUS FOR INTEGRATING ENTERPRISE APPLICATIONS - A method and apparatus is provided for integrating an application into a network of computing resources. Applications using this integration have a virtualized access to one or more computing resources associated with the network. Virtualization is generally assured through at least one network connection between the virtual layer and the native network. Together, the virtual access is used to generate a virtual application network capable of providing the application access to the network of computing resources. The application is created into an orchestration of operations to manipulate the one or more computing resources according to a business process. As needed, the application and orchestration can be further partitioning into components to be distributed and executed over the virtual application network using the virtualized access. | 04-09-2009 |
Mac Stevens, San Jose, CA US
Patent application number | Description | Published |
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20090055791 | PROCESS AND APPARATUS FOR ADJUSTING TRACES - Traces routed through a computer depiction of a routing area of an electronics system comprise a plurality of connected nodes. Forces are assigned to the nodes, and the nodes are moved in accordance with the forces. The forces may be based on such things as the proximity of the nodes to each other and to obstacles in the routing area. This tends to smooth, straighten and/or shorten the traces, and may also tend to correct design rule violations. | 02-26-2009 |
Mark G. Stevens, Rancho Cucamonga, CA US
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20090156385 | Manufacture and use of engineered carbide and nitride composites - Carbides and nitrides are provided containing a controlled amount of pre-determined diluents and methods for their manufacture and use are disclosed. The pre-determined diluents include at least one of the silica, silicon metal, carbon, alumina, boron oxide, alkaline earth oxides such as calcium oxide, magnesium oxide, alkali oxides such as sodium oxide, potassium oxide, iron oxide, titanium oxide, and other components typically present in glass, ceramics, or metals. The carbides and nitrides with pre-determined diluents are formed by optionally pyrolyzing a precursor material to form a carboneous mixture and heat treating the carboneous mixture for a pre-determined time and at an elevated temperature during which carbon and/or nitrogen reacts with silica in the mixture to form carbides and/or nitrides and controlled amounts of pre-determined diluents. The carbides and nitrides disclosed herein may be used as blowing agents in a glass, ceramic, or metal forming processes or for promoting dispersion of the carbides and nitrides throughout a glass, ceramic, or metal composite. | 06-18-2009 |
20090200512 | Manufacture and Use of Engineered Carbide and Nitride Composites - Carbides and nitrides are provided containing a controlled amount of pre-determined diluents and methods for their manufacture and use are disclosed. The pre-determined diluents include at least one of the silica, silicon metal, carbon, alumina, boron oxide, alkaline earth oxides such as calcium oxide, magnesium oxide, alkali oxides such as sodium oxide, potassium oxide, iron oxide, titanium oxide, and other components typically present in glass, ceramics, or metals. The carbides and nitrides with pre-determined diluents are formed by optionally pyrolyzing a precursor material to form a carboneous mixture and heat treating the carboneous mixture for a pre-determined time and at an elevated temperature during which carbon and/or nitrogen reacts with silica in the mixture to form carbides and/or nitrides and controlled amounts of pre-determined diluents. The carbides and nitrides disclosed herein may be used as blowing agents in a glass, ceramic, or metal forming processes or for promoting dispersion of the carbides and nitrides throughout a glass, ceramic, or metal composite. | 08-13-2009 |
Mark Liu Stevens, Laguna Hills, CA US
Patent application number | Description | Published |
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20090268229 | Multifunction Peripheral Browser Control for Application Integration - A multi-functional peripheral (MFP) browser having integrated scan, print, and/or e-mail functionality may be integrated within a system and support methods of scanning, printing and e-mailing via the MFP display. | 10-29-2009 |
20120278616 | System and Method for Securely Decrypting Files Wirelessly Transmitted to a Mobile Device - A method is provided for securely decrypting files that are wirelessly sent to a mobile device. A mobile device typically has a wireless interface, such as a cellular telephone or WiFi interface that can be used to accept an encrypted file from a first remote device. A decryption key representation is accepted from a second remote device via a personal proximity interface which can be a camera, microphone, or near-field radio frequency (RF) detector. In one aspect, the first device can, for example, be a multi-functional peripheral (MFP), a network server, or a computer. In another aspect, the first and second devices can be the same device, such as an MFP or a computer. A mobile device conversional application converts the decryption key representation to a digital decryption key, and the digital decryption key is then used to decrypt the encrypted file. | 11-01-2012 |
Michael Charles Stevens, San Jose, CA US
Patent application number | Description | Published |
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20080201210 | SYSTEM AND METHOD FOR MANAGING INTELLECTUAL PROPERTY - The present invention relates to methods and systems for intellectual property management. In an embodiment, a system includes an intellectual property asset inventory system to manage an inventory of intellectual property assets. A product inventory system manages an inventory of products, where the inventory of products corresponds to a plurality of products and one or more of the products of the plurality of products are associated with one or more of the intellectual property assets of the plurality of intellectual property assets. A marketing management system manages a plurality of marketing projects, where one or more of the marketing projects of the plurality of marketing projects are associated with at least one of (i) one or more products of the plurality of products, and (ii) one or more intellectual property assets of the plurality of intellectual property assets. | 08-21-2008 |
Paul Stevens, Felton, CA US
Patent application number | Description | Published |
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20090240692 | HIERARCHICAL TAGS WITH COMMUNITY-BASED RATINGS - A method for generating and maintaining hierarchical tags with community-based ratings is provided. Tags for media streams are organized into a hierarchical format. Users may select tags from the hierarchical tag database that describes a particular multimedia content. If the user is unable to locate a desired tag, the user may submit a new tag. Upon submission of the new tag, a librarian approves the tag before storing and placing the tag in the hierarchical tag database. Users are also able to rate the quality of the association between the tag and the multimedia content. If a tag is rated low, the tag may be removed from the hierarchical tag database. If the tag is rated highly, display of the tag in a list of tags becomes more prominent. | 09-24-2009 |
20100027976 | In-Band Data Recognition And Synchronization System - A method and apparatus for recognizing and synchronizing to in-band data at a multimedia device is provided. A content stream includes in-band data. The in-band data is processed and in-band data pattern data associated with the content stream are created. Metadata are attached to the event identification data. The event identification data are provided to multimedia devices which receive broadcasted multimedia content streams containing video programs with in-band data. The in-band data are processed and compared to the event identification data. If a match occurs, the multimedia device uses the metadata to perform specified actions. | 02-04-2010 |
20100033624 | In-Band Data Recognition And Synchronization System - A method and apparatus for recognizing and synchronizing to in-band data at a multimedia device is provided. A content stream includes in-band data. The in-band data is processed and in-band data pattern data associated with the content stream are created. Metadata are attached to the event identification data. The event identification data are provided to multimedia devices which receive broadcasted multimedia content streams containing video programs with in-band data. The in-band data are processed and compared to the event identification data. If a match occurs, the multimedia device uses the metadata to perform specified actions. | 02-11-2010 |
20110110646 | CREATING AND VIEWING CUSTOMIZED MULTIMEDIA SEGMENTS - A system for creating and viewing customized multimedia segments allows a user to create event identification data from in-band data in a program stream. The in-band data is processed and compiled into event identification data associated with the content stream. The event identification data identifies patterns or sequences of in-band data associated with events in the content stream. Metadata are also included in the event identification data. The event identification data is provided to multimedia devices which receive multimedia content streams containing content streams with in-band data. The in-band data are parsed and compared to the event identification data. If a match occurs, the multimedia device uses the metadata to identify events or perform specified actions. | 05-12-2011 |
20120328263 | Method And Apparatus For Advertisement Placement In A User Dialog On A Set-Top Box - Methods and apparatuses for presenting targeted advertisements to DVR users are described. After a DVR has finished playing a recorded television program, or in response to other specified events, the DVR presents a screen which comprises a “save or delete” menu. In addition to the “save” and “delete” options, the menu additionally comprises one or more other options. Each of these other options may correspond to a separate promotional item. For example, a user's selection of such an option may cause the DVR to display or play an advertisement on the user's television set. Additionally or alternatively, these other options, when selected by a user, may cause the DVR to display a user interface through which the user can actually purchase a product or service. The product or service advertised or offered may be one that was featured or referenced in the television program that the user was just watching. | 12-27-2012 |
20130195423 | Method and Apparatus for Advertisement Placement in a User Dialog on a Set-Top Box - Methods and apparatuses for presenting targeted advertisements to DVR users are described. After a DVR has finished playing a recorded television program, or in response to other specified events, the DVR presents a screen which comprises a “save or delete” menu. In addition to the “save” and “delete” options, the menu additionally comprises one or more other options. Each of these other options may correspond to a separate promotional item. For example, a user's selection of such an option may cause the DVR to display or play an advertisement on the user's television set. Additionally or alternatively, these other options, when selected by a user, may cause the DVR to display a user interface through which the user can actually purchase a product or service. The product or service advertised or offered may be one that was featured or referenced in the television program that the user was just watching. | 08-01-2013 |
20130318552 | METHOD AND APPARATUS FOR AUTOMATED BIDDING AND ADVERTISEMENT PLACEMENT ON A SET-TOP BOX - Methods and apparatuses for presenting targeted advertisements to DVR users are described. After a DVR has finished playing a recorded television program, or in response to other specified events, the DVR presents a screen which comprises a “save or delete” menu. In addition to the “save” and “delete” options, the menu additionally comprises one or more other options. Each of these other options may correspond to a separate promotional item. For example, a user's selection of such an option may cause the DVR to display or play an advertisement on the user's television set. Additionally or alternatively, these other options, when selected by a user, may cause the DVR to display a user interface through which the user can actually purchase a product or service. The product or service advertised or offered may be one that was featured or referenced in the television program that the user was just watching. | 11-28-2013 |
20140059593 | IN-BAND DATA RECOGNITION AND SYNCHRONIZATION SYSTEM - A method and apparatus for recognizing and synchronizing to in-band data at a multimedia device is provided. A content stream includes in-band data. The in-band data is processed and in-band data pattern data associated with the content stream are created. Metadata are attached to the event identification data. The event identification data are provided to multimedia devices which receive broadcasted multimedia content streams containing video programs with in-band data. The in-band data are processed and compared to the event identification data. If a match occurs, the multimedia device uses the metadata to perform specified actions. | 02-27-2014 |
20140250463 | METHOD AND APPARATUS FOR ADVERTISEMENT PLACEMENT IN A USER DIALOG ON A SET-TOP BOX - Methods and apparatuses for presenting targeted advertisements to DVR users are described. After a DVR has finished playing a recorded television program, or in response to other specified events, the DVR presents a screen which comprises a “save or delete” menu. In addition to the “save” and “delete” options, the menu additionally comprises one or more other options. Each of these other options may correspond to a separate promotional item. For example, a user's selection of such an option may cause the DVR to display or play an advertisement on the user's television set. Additionally or alternatively, these other options, when selected by a user, may cause the DVR to display a user interface through which the user can actually purchase a product or service. The product or service advertised or offered may be one that was featured or referenced in the television program that the user was just watching. | 09-04-2014 |
Ramsey M. Stevens, Danville, CA US
Patent application number | Description | Published |
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20090246400 | NANOSTRUCTURE DEVICES AND FABRICATION METHOD - An ion flux is directed to a carbon nanotube to permanently shape, straighten and/or bend the carbon nanotube into a desired configuration. Such carbon nanotubes have many properties that make them ideal as probes for Scanning Probe Microscopy and many other applications. | 10-01-2009 |
20100003500 | CARBON NANOTUBE DEVICE AND PROCESS FOR MANUFACTURING SAME - The present invention contemplates a variety of methods and techniques for fabricating an improved carbon nanotube (CNT) device such as an AFM probe. A CNT is first formed on a desired location such as a substrate. The CNT and substrate are then covered with a protective layer through a CVD or other suitable process. Then a length of the CNT is exposed through etching or other suitable process, the exposed length being formed to a length suitable for a desired application for the CNT device. | 01-07-2010 |
20100068124 | NANOSTRUCTURE DEVICES AND FABRICATION METHOD - An ion flux is directed to a carbon nanotube to permanently shape, straighten and/or bend the carbon nanotube into a desired configuration. Such carbon nanotubes have many properties that make them ideal as probes for Scanning Probe Microscopy and many other applications. | 03-18-2010 |
20100142017 | Carbon nanotube signal modulator and photonic transmission device - The present invention contemplates a variety of methods and techniques for fabricating a carbon nanotube (CNT) signal modulator for reducing, eliminating, or enhancing the resonance interaction between photonic elements, and a photonic transmission device that may incorporate the signal modulator. The CNT signal modulator comprises a gate CNT on a substrate in a position for receiving an input photonic signal and an input modulation signal; and transmitting an output photonic signal that is reduced, eliminated, or enhanced through the selection of the input modulation signal; and an input modulation signal sender for sending the input modulation signal to the gate CNT and creating the modulated output photonic signal from the gate CNT. The photonic transmission device can contain a plurality of CNTs, each having functional antenna forms that are capable of a resonance interaction of photons between adjacent CNTs when formed as an array on a substrate. The photonic transmission device can also comprise the CNT signal modulator. | 06-10-2010 |
20110168954 | CARBON NANOTUBE BASED COMPOSITE SURFACE ENHANCED RAMAN SCATTERING (SERS) PROBE - An electromagnetic and/or chemical enhancement which greatly enhances the Raman signal response for Surface Enhanced Raman is directed to molecular probe systems. Such molecular probe systems have many properties that make them ideal as probes for Scanning Probe Microscopy, Atomic Force Microscopy, and many other applications. | 07-14-2011 |
20120206085 | CARBON NANOTUBE SOLAR POWER COLLECTION DEVICE - Various embodiments of the present invention contemplates a variety of methods and techniques for fabricating a carbon nanotube (CNT) signal modulator for reducing, eliminating, or enhancing the resonance interaction between photonic elements, and a photonic transmission device that may incorporate the signal modulator. These fabrication techniques can be used to create a nanoantennas, rectennas, and efficient solar energy devices. For example, a photonic collection device can include an array of carbon nanofibers (CNFs), CNTs, nanowires or other suitable conducting material, each having functional antenna forms that are capable of harvesting electromagnetic radiation and directing electrons to a rectifying barrier to generate a DC current. Each CNF in the array can have a diameter and length suitable to allow for the havesting electromagnetic radiation within a range of desired wavelengths. | 08-16-2012 |
Raymond C. Stevens, La Jolla, CA US
Patent application number | Description | Published |
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20110031438 | METHODS AND COMPOSITIONS FOR OBTAINING HIGH-RESOLUTION CRYSTALS OF MEMBRANE PROTEINS - The invention describes compositions and method useful for the crystallization of membrane proteins. | 02-10-2011 |
20110130543 | CHOLESTEROL CONSENSUS MOTIF OF MEMBRANE PROTEINS - The invention provides the structure of a human β2-adrenergic receptor, a cholesterol consensus motif, and methods of identifying modulators of G-protein coupled receptors (GPCRs). Methods of using the modulators of the receptor, GPCRs, and the cholesterol consensus motif are also provided. | 06-02-2011 |
20110171226 | Novel Subtype of Closteridium Botulinum Neurotoxin Type A and Uses Thereof - A novel subtype of type A botulinum neurotoxin (BoNT/A) is disclosed in the application. Methods to purify the neurotoxin as well as uses thereof are also disclosed. | 07-14-2011 |
20120100593 | Crystals of membrane proteins - A polypeptide in crystalline form comprises a G-protein coupled receptor (GPCR) with an IC3 loop substituted by an amino acid residue sequence of lysozyme. | 04-26-2012 |
20120123092 | HUMAN A2A ADENOSINE RECEPTOR CRYSTALS AND USES THEREOF - The invention provides the structure of human A2A adenosine receptor protein bound to an antagonist. Methods of using one or more binding sites and other features of this G-protein coupled receptor to develop new therapeutics are also disclosed. | 05-17-2012 |
20120288913 | NOVEL FUSION PARTNERS FOR THE PURPOSE OF CRYSTALLIZING G-PROTEIN COUPLED RECEPTORS - GPCR-fusion partner proteins comprising G protein coupled receptors (GPCRs) of GPCRs and fusion partners such as rubredoxin, cytochrome b562 RIL (Bril, bRIL, BRIL), T4 lysozyme C-terminal fragment (Cterm-T4L), flavodoxin, or xylanase either substituted for some or all of the third intracellular loop of the GPCR between the fifth and sixth helix of the GPCR are described or attached to an terminus or C terminus of the GPCR. GPCR-fusion partner proteins in crystalline form, optionally of a quality suitable for x-ray crystallographic structure determination of the GPCR, are described. Methods of using fusion partners in GPCR-fusion partner proteins to support crystallization of GPCR-fusion partner proteins for x-ray crystallographic structure determination of the GPCR, are described. Methods of identifying other suitable fusion partners through screening of protein data banks are also described. | 11-15-2012 |
20130210117 | CRYSTALS OF MEMBRANE PROTEINS - A polypeptide in crystalline form comprises a G-protein coupled receptor (GPCR) with an IC3 loop substituted by an amino acid residue sequence of lysozyme. | 08-15-2013 |
Robin Stevens, San Mateo, CA US
Patent application number | Description | Published |
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20110258204 | SYSTEM FOR USING KEYWORD PHRASES ON A PAGE TO PROVIDE CONTEXTUALLY RELEVANT CONTENT TO USERS - A process is described for assessing the suitability of particular keyword phrases for use in serving contextually relevant content for display on pages of network-accessible sites. In one embodiment, the process involves scoring the key phrases based in part on collected user behavioral data, such as view counts of associated social media content items. A process is also disclosed in which selected keyword phrases on a page are transformed into links that can be selected by a user to view bundled content that is related to such keyword phrases. | 10-20-2011 |
Roger Stevens, San Jose, CA US
Patent application number | Description | Published |
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20110034989 | RAPID-EXCHANGE BALLOON CATHETER SHAFT AND METHOD - A balloon catheter or stent delivery system for medical treatment of a patient has a proximal hub, a balloon, and an improved shaft design. The catheter shaft has a rapid-exchange configuration, and a tubular outer body that includes a hypotube extending from the catheter proximal end to a position at or near a proximal leg of the balloon. An inner tubular body defines a guidewire lumen extending from a distal guidewire port at the catheter distal end to a proximal port located at a position between the balloon and the hub. A distal leg of the balloon is directly or indirectly affixed to the inner body, and a proximal leg of the balloon is affixed to the distal end of the outer body. The hypotube has an aperture for accepting the inner body proximal end, and a circumferential cut pattern. The cut pattern adds flexibility, and may extend from the hypotube distal end to a position proximal of the proximal guidewire port. The cut pattern may have any desired shape, including a spiral, a helical undulating path, or an overlapping serpentine path with inflection points, for example. The hypotube has a fluid-tight covering such as a heat-shrink polymer, so the outer body supports pressure of an inflation medium. The proximal guidewire port may be positioned on or between the individual portions of the cut pattern, or at a position beyond the cut pattern. | 02-10-2011 |
Ronald Stevens, Santa Ramon, CA US
Patent application number | Description | Published |
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20080276860 | CROSS FLOW APPARATUS AND METHOD FOR HYDRIDE VAPOR PHASE DEPOSITION - A method and apparatus for hydride vapor phase epitaxial (HVPE) deposition is disclosed. In the HVPE process, a hydride gas flows over a metal source to react with the metal source, which then reacts at the surface of a substrate to deposit a metal nitride layer. The metal source comprises gallium, aluminum, and/or indium. The hydride gas is evenly provided over the metal source to increase efficiency of hydride-metal source reaction. An exhaust positioned diametrically across the chamber from the metal source creates a cross flow of the hydride-metal source product and nitrogen precursor across the chamber tangential to the substrate. A purge gas flowing perpendicular to the cross flow directs the hydride-metal source product and nitrogen precursor to remain as close to the substrate as possible. | 11-13-2008 |
Ronald H. Stevens, Carlsbad, CA US
Patent application number | Description | Published |
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20110213211 | SYSTEMS AND METHODS FOR ASSESSING TEAM DYNAMICS AND EFFECTIVENESS - Techniques for monitoring neurophysiologic indicators of the members of a team while performing one or more collaborative tasks, for analyzing the collected neurophysiologic data and environmental data, for generating feedback, and for generating assessments of the performance of the team based on the collected data are provided. Feedback can be created based on the assessments of the team performance. Assessments of team performance can be performed in real time and feedback can also be provided in real time. In other embodiments, feedback can be provided to team members and/or the team as a whole after training exercise and/or simulation has been completed. | 09-01-2011 |
Ronald H. Stevens, Marina Del Rey, CA US
Patent application number | Description | Published |
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20090075246 | SYSTEM AND METHOD FOR QUANTIFYING STUDENT'S SCIENTIFIC PROBLEM SOLVING EFFICIENCY AND EFFECTIVENESS - In a computer implemented system and method for analyzing problem solving abilities, analytic models are produced to quantify how students construct, modify and retain problem solving strategies as they learn to solve science problems online. Item response theory modeling is used to provide continually refined estimates of problem solving ability as students solve a series of simulations. In parallel, student's strategies are modeled by self-organizing artificial neural network analysis, using the actions that students take during problem solving as the classifying inputs. This results in strategy maps detailing the qualitative and quantitative differences among problem solving approaches. The results are used to provide reports of strategic problem solving competency for a group of students so that teachers can modify teaching strategies to overcome noted deficiencies. | 03-19-2009 |
Rudd Stevens, San Mateo, CA US
Patent application number | Description | Published |
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20120167073 | MANAGED UPGRADES OF COMPONENTS IN AN INTEGRATED SOFTWARE AND HARDWARE SYSTEM - A set of managed upgrades is described for an integrated software and hardware system that functions as a communications service broker in a telecommunications (telecom) network environment. The system can be used to perform mediation and orchestration of services in the telecom network. The system includes a chassis having a plurality of enclosure slots that are adapted to contain computing blades. Each blade includes a managed server. In addition, the system includes an administration console for managing updates, installation and/or rollbacks on the computing blades. The console receives a request to update a deployment package on a managed server and sequentially distributes the deployment package to each the managed server, wherein the managed servers process the deployment package. The administration console then updates a set of metadata associated with the deployment package in a deployment packages directory. | 06-28-2012 |
Russell Stevens, San Jose, CA US
Patent application number | Description | Published |
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20120242304 | Source Driver Current Fold-Back Protection - A load current is limited to a safe level with a current protection logic circuit within a first selected interval after detection of a fault condition. The current protection logic circuit returns the load current to a normal level within a second selected interval after correction of the fault condition, wherein said safe level is less than one half of the normal level. The current protection logic circuit is a feature of a high side driver comprising at least two source drivers, each source driver being configured to switch an electrical load to a common power supply, and comprising a respective current protection logic circuit. | 09-27-2012 |
Sean Stevens, San Francisco, CA US
Patent application number | Description | Published |
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20110145937 | Mice That Make Heavy Chain Antibodies - Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion in an immunoglobulin constant region CH1 gene (optionally a deletion in a hinge region) of an IgG, IgA, IgD, and/or IgE, and wherein the mouse is capable of expressing a functional IgM. Genetically modified mice are described, including mice having a functional IgM gene and modified to have a deletion of a CH1 domain and a hinge region in a heavy chain constant domain that is not an IgM, e.g., in an IgG heavy chain constant domain. Genetically modified mice that make human variable/mouse constant chimeric heavy chain antibodies (antibodies that lack a light chain), fully mouse heavy chain antibodies, or fully human heavy chain antibodies are provided. | 06-16-2011 |
20110154512 | Humanized Fc gamma R Mice - Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided. | 06-23-2011 |
20110195454 | Common Light Chain Mouse - A genetically modified mouse is provided, wherein the mouse is incapable of rearranging and expressing an endogenous mouse immunoglobulin light chain variable sequence, wherein the mouse expresses only one or two human light chain variable domains encoded by human immunoglobulin sequences operably linked to the mouse kappa (κ) constant gene at the endogenous mouse κ locus, wherein the mouse expresses a reverse chimeric antibody having a light chain variable domain derived from one of only two human light chain variable region gene segments and a mouse κ constant domain, and a human heavy chain variable domain and a mouse heavy chain constant domain, from an endogenous mouse heavy chain locus. Bispecific epitope-binding proteins that are fully human are provided, comprising two different heavy chains that associate with an identical light chain that comprises a variable domain derived from one of two different human light chain variable region gene segments. | 08-11-2011 |
20110256556 | Humanized FcgR Mice - Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided. | 10-20-2011 |
20110269187 | High Affinity Human Antibodies to Human IL-18 Receptor - An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof. | 11-03-2011 |
20120003697 | HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR - A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a K | 01-05-2012 |
20120021409 | Common Light Chain Mouse - A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making light chain variable regions in mice, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, are provided. | 01-26-2012 |
20120045440 | METHOD OF TREATING RHEUMATOID ARTHRITIS WITH AN ANTI-IL-6R ANTIBODY - The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof. | 02-23-2012 |
20120070861 | Human Lambda Light Chain Mice - Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided. | 03-22-2012 |
20120073004 | Hybrid Light Chain Mice - Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided. | 03-22-2012 |
20120096572 | Mice That Make VL Binding Proteins - Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene segments, and J gene segments with at least one light chain V gene segment and at least one light chain J gene segment. Mice that make binding proteins that comprise a light chain variable domain operably linked to a heavy chain constant region are provided. Binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Modified cells, embryos, and mice that encode sequences for making the binding proteins are provided. | 04-19-2012 |
20120135010 | HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN IL-4 RECEPTOR - An isolated human antibody or antigen binding fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4Rα) with an affinity constant (K | 05-31-2012 |
20120192300 | Common Light Chain Mouse - A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making light chain variable regions in mice, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, are provided. | 07-26-2012 |
20120258098 | Method of Treating Rheumatoid Arthritis with an Anti-IL-6R Antibody - The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof. | 10-11-2012 |
20120260357 | Low Affinity FcgR Deficient Mice - Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided. | 10-11-2012 |
20120322108 | Adam6 Mice - Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided. | 12-20-2012 |
20130045492 | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain - A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided. | 02-21-2013 |
20130109053 | Genetically Modified T Cell Receptor Mice | 05-02-2013 |
20130111616 | Genetically Modified Major Histocompatibility Complex Mice | 05-02-2013 |
20130111617 | Genetically Modified Major Histocompatibility Complex Mice | 05-02-2013 |
20130117873 | HUMANIZED IL-6 AND IL-6 RECEPTOR - Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Rα locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus. | 05-09-2013 |
20130157313 | HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR - A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a K | 06-20-2013 |
20130160153 | Humanized Light Chain Mice - Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin λ light chain variable domain. | 06-20-2013 |
20130185819 | Genetically Modified Major Histocompatibility Complex Animals - The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided. | 07-18-2013 |
20130185820 | Genetically Modified Major Histocompatibility Complex Animals - The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided. | 07-18-2013 |
20130185821 | Common Light Chain Mouse - A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided. | 07-18-2013 |
20130198879 | Humanized Universal Light Chain Mice - Mice, tissues, cells, and genetic material are provided that comprise a humanized heavy chain immunoglobulin locus, a humanized light chain locus that expresses a universal light chain, and a gene encoding an ADAM6 or ortholog or homolog or functional fragment thereof. Mice are provided that express humanized heavy chains comprising human variable domains, and that express humanized light chains comprising human variable domains wherein the light chains are derived from no more than one, or no more than two, light chain V and J or rearranged V/J sequences. Fertile male mice that express antibodies with universal light chains and humanized heavy chains are provided. Methods and compositions for making bispecific binding proteins are provided. | 08-01-2013 |
20130198880 | MICE EXPRESSING A LIMITED IMMUNOGLOBULIN LIGHT CHAIN REPERTOIRE - A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that present a choice of two human light chain variable gene segments such that the immunoglobulin light chains expresses by the mouse comprise one of the two human light chain variable gene segments. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. | 08-01-2013 |
20130212719 | Humanized Rodents that Express Heavy Chain Containing VL Domains - Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a rodent (e.g., a mouse), wherein the non-human animals rearrange human immunoglobulin light chain gene segments in the context of heavy chain constant regions and express immunoglobulin-like molecules comprising human immunoglobulin light chain variable domains fused to heavy chain constant domains that are cognate with human immunoglobulin light chain variable domains fused to light chain constant domains. | 08-15-2013 |
20130254911 | ADAM6 MICE - Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided. | 09-26-2013 |
20130302836 | COMMON LIGHT CHAIN MOUSE - A genetically modified mouse is provided, wherein the mouse is incapable of rearranging and expressing an endogenous mouse immunoglobulin light chain variable sequence, wherein the mouse expresses only one or two human light chain variable domains encoded by human immunoglobulin sequences operably linked to the mouse kappa (κ) constant gene at the endogenous mouse κ locus, wherein the mouse expresses a reverse chimeric antibody having a light chain variable domain derived from one of only two human light chain variable region gene segments and a mouse κ constant domain, and a human heavy chain variable domain and a mouse heavy chain constant domain, from an endogenous mouse heavy chain locus. Bispecific epitope-binding proteins that are fully human are provided, comprising two different heavy chains that associate with an identical light chain that comprises a variable domain derived from one of two different human light chain variable region gene segments. | 11-14-2013 |
20130323790 | HUMAN LAMBDA LIGHT CHAIN MICE - Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided. | 12-05-2013 |
20130326647 | HUMAN LAMBDA LIGHT CHAIN MICE - Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided. | 12-05-2013 |
20130333057 | Humanized Non-Human Animals with Restricted Immunoglobulin Heavy Chain Loci - Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human V | 12-12-2013 |
20140013457 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 01-09-2014 |
20140017228 | HUMANIZED LIGHT CHAIN MICE - Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin λ light chain variable domain. | 01-16-2014 |
20140017229 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 01-16-2014 |
20140017238 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 01-16-2014 |
20140017781 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 01-16-2014 |
20140017782 | Methods for Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 01-16-2014 |
20140018522 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 01-16-2014 |
20140020124 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 01-16-2014 |
20140020125 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 01-16-2014 |
20140023637 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 01-23-2014 |
20140033336 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 01-30-2014 |
20140033337 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 01-30-2014 |
20140041068 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 02-06-2014 |
20140130193 | MICE THAT MAKE VL BINDING PROTEINS - Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene segments, and J gene segments with at least one light chain V gene segment and at least one light chain J gene segment. Mice that make binding proteins that comprise a light chain variable domain operably linked to a heavy chain constant region are provided. Binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Modified cells, embryos, and mice that encode sequences for making the binding proteins are provided. | 05-08-2014 |
20140130194 | MICE THAT MAKE VL BINDING PROTEINS - Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene segments, and J gene segments with at least one light chain V gene segment and at least one light chain J gene segment. Mice that make binding proteins that comprise a light chain variable domain operably linked to a heavy chain constant region are provided. Binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Modified cells, embryos, and mice that encode sequences for making the binding proteins are provided. | 05-08-2014 |
20140255390 | Method of Treating Rheumatoid Arthritis With An Anti-IL-6R Antibody - The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof. | 09-11-2014 |
20140255995 | HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR - A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a K | 09-11-2014 |
20150059009 | METHODS FOR MAKING FULLY HUMAN BISPECIFIC ANTIBODIES USING A COMMON LIGHT CHAIN - A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided. | 02-26-2015 |
Sean Stevens, San Diego, CA US
Patent application number | Description | Published |
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20100316636 | Method of Treating Rheumatoid Arthritis with an IL-6R Antibody - The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof. | 12-16-2010 |
20110200982 | GENETICALLY MODIFIED MICE AND ENGRAFTMENT - A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/Il2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., | 08-18-2011 |
20130022996 | GENETICALLY MODIFIED MICE AND ENGRAFTMENT - A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., | 01-24-2013 |
20130024957 | GENETICALLY MODIFIED MICE AND ENGRAFTMENT - A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., | 01-24-2013 |
20130042330 | HUMANIZED M-CSF MICE - Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice. These mice find use in a number of applications, such as in modeling human immune disease and pathogen infection; in in vivo screens for agents that modulate hematopoietic cell development and/or activity, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to hematopoietic cells; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on hematopoietic cells; in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy, etc. | 02-14-2013 |
20140073010 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 03-13-2014 |
20140090095 | Genetically Modified Mice and Engraftment - A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/Il2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., | 03-27-2014 |
20140134662 | GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHODS OF USE THEREOF - Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human IL-6 operably linked to an IL-6 promoter. In some instances, the genetically modified non-human animal expressing human IL-6 also expresses at least one of human M-CSF, human IL-3, human GM-CSF, human SIRPa or human TPO. In some instances, the genetically modified non-human animal is immunodeficient. In some such instances, the genetically modified non-human animal is engrafted with healthy or diseased human hematopoietic cells. Also provided are methods for using the subject genetically modified non-human animals in modeling human hematopoietic cell development, function, and/or disease, as well as reagents and kits thereof that find use in making the subject genetically modified non-human animals and/or practicing the subject methods. | 05-15-2014 |
20140137275 | HYBRID LIGHT CHAIN MICE - Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided. | 05-15-2014 |
20140154701 | HUMANIZED FC GAMMA R MICE - Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided. | 06-05-2014 |
20140157445 | LOW AFFINITY FCGR DEFICIENT MICE - Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided. | 06-05-2014 |
20140213773 | ADAM6 MICE - Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided. | 07-31-2014 |
20140289876 | MICE THAT MAKE HEAVY CHAIN ANTIBODIES - Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion in an immunoglobulin constant region CH1 gene (optionally a deletion in a hinge region) of an IgG, IgA, IgD, and/or IgE, and wherein the mouse is capable of expressing a functional IgM. Genetically modified mice are described, including mice having a functional IgM gene and modified to have a deletion of a CH1 domain and a hinge region in a heavy chain constant domain that is not an IgM, e.g., in an IgG heavy chain constant domain. Genetically modified mice that make human variable/mouse constant chimeric heavy chain antibodies (antibodies that lack a light chain), fully mouse heavy chain antibodies, or fully human heavy chain antibodies are provided. | 09-25-2014 |
20150024412 | Humanized FcgammaR Mice - Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided. | 01-22-2015 |
20150040253 | GENETICALLY MODIFIED MAJOR HISTOCOMPATIBILITY COMPLEX MICE - The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided. | 02-05-2015 |
20150047061 | Humanized M-CSF Mice - Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice. These mice find use in a number of applications, such as in modeling human immune disease and pathogen infection; in in vivo screens for agents that modulate hematopoietic cell development and/or activity, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to hematopoietic cells; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on hematopoietic cells; in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy, etc. | 02-12-2015 |
20150089680 | Human Lambda Light Chain Mice - Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided. | 03-26-2015 |
Timothy Stevens, Emeryville, CA US
Patent application number | Description | Published |
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20140259718 | METHOD AND SYSTEM FOR WIRING A PICTURE FRAME AND GENERATING TEMPLATES TO HANG PICTURE IN VARIOUS LAYOUTS - Disclosed here are methods, devices, paradigms and structures for wiring a picture frame, and for generating user defined templates for hanging picture frames wired using the device in various layouts. The device allows the maker of the frame to install a hanging wire to the frame at a predefined position, for example, at a predefined distance from a top edge of the frame. A spring-loaded peg mounted on a flat slab, at a predefined distance from a wall member of the device, allows wiring the frame such that the apex of the wire is at the predefined distance from the top edge of the frame. The frame is placed in the device with the top edge of the frame adjacent to the wall member. The flat slab is configured to move vertically on a channel guide mounted on the wall member to accommodate varying thickness of the frame. | 09-18-2014 |
Walter Stevens, San Jose, CA US
Patent application number | Description | Published |
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20140236127 | OCCLUSIVE IMPLANTS FOR HOLLOW ANATOMICAL STRUCTURES, DELIVERY SYSTEMS, AND RELATED METHODS - An implant arid delivery system including a female coupler at a proximal end of the implant and a male coupler at a distal end of an elongate tubular delivery member. The male coupler is insertable within the female coupler and expandable under the influence of an elongate control member that is slidable within the tubular delivery member. Expansion of the male coupler locks the implant to the tubular delivery member. Withdrawal of the control member unlocks the implant from the tubular delivery member, enabling placement of the implant within a body. | 08-21-2014 |
Walter J. Stevens, Santa Clara, CA US
Patent application number | Description | Published |
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20080292255 | SYSTEMS AND METHODS FOR TREATING HOLLOW ANATOMICAL STRUCTURES - An apparatus for treating a hollow anatomical structure can include a light delivery device. The light delivery device comprises an optical fiber that is located in a lumen of a shaft suitable for insertion into the hollow anatomical structure and has a fiber tip located proximal of a distal end of the shaft during treatment of the hollow anatomical structure. The apparatus can further include a liquid source for providing a liquid flow over the optical fiber at a predetermined liquid flow rate. | 11-27-2008 |
20140133814 | SYSTEMS AND METHODS FOR TREATING HOLLOW ANATOMICAL STRUCTURES - An apparatus for treating a hollow anatomical structure can include a light delivery device. The light delivery device comprises an optical fiber that is located in a lumen of a shaft suitable for insertion into the hollow anatomical structure and has a fiber tip located proximal of a distal end of the shaft during treatment of the hollow anatomical structure. The apparatus can further include a liquid source for providing a liquid flow over the optical fiber at a predetermined liquid flow rate. | 05-15-2014 |
William A. Stevens, Folsom, CA US
Patent application number | Description | Published |
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20110307878 | SYSTEM FOR ATOMICALLY UPDATING A PLURALITY OF FILES - A method for updating platform firmware is disclosed. This capability is facilitated by a standard software abstraction for a firmware storage device, known as Firmware Volume (FV) that is managed through a Firmware File System (FFS). The FFS enables firmware files to be created, deleted, and updated individually. The FFS also enables a plurality of firmware files to be updated atomically by managing file state information via state bits stored in a file header of each firmware file, whereby an atomic change to a single state bit simultaneously causes the FFS to use an updated set of firmware files in place of an original set of firmware files. | 12-15-2011 |
William C. Stevens, Escondido, CA US
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20080234270 | Pyrrole Derivatives As Pharmaceutical Agents - Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors. | 09-25-2008 |
20110301128 | Pyrrole Derivatives As Pharmaceutical Agents - Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors. | 12-08-2011 |
William C. Stevens, La Jolla, CA US
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20100069367 | LXR and FXR Modulators - Compounds of the invention are disclosed, such as compounds of formulae LX-LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R | 03-18-2010 |