Stefanick
Jared Stefanick, Mishawaka, IN US
Patent application number | Description | Published |
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20140287049 | NANOPARTICLE-BASED DRUG DELIVERY - Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cell. The therapeutic component may be subsequently released within an endocytic vesicle of the target cell. Nanoparticle-based drug delivery systems as described herein may provide improved efficacy and/or reduced toxicity. | 09-25-2014 |
Matthew Owen Stefanick, Peoria, IL US
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20100132341 | Power system - The present disclose is directed to a power system. The power system may include a power source that creates a flow of exhaust. The power system may further include a particulate collection device that receives the flow of exhaust. The power system may also include an additive injector located downstream of the power source, the additive injector may be configured to provide a controlled supply of additive to the flow of exhaust. | 06-03-2010 |
Robert J. Stefanick, White Lake, MI US
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20120024107 | TRANSMISSION WITH SPLASH LUBRICATION SYSTEM - A transmission is provided with a transmission case partially defining a cavity containing unpressurized fluid. The transmission case has a first feature configured to collect splashed fluid and a second feature configured to direct the collected fluid to a chamber at least partially formed by the transmission case. A cap connected to the transmission case has an opening and an orifice offset from the opening. Fluid flows from the chamber through the orifice to a component when fluid reaches a first level in the chamber and flows through the central opening through an axial passage in the shaft to other components when fluid reaches a second level in the chamber. Fluid flow is provided to components through an axial passage from both ends of a rotatable shaft, such as an input shaft. The axial passage may have a threaded end to pump oil away from the end and prevent backflow. | 02-02-2012 |
Stephen M. Stefanick, Phillipsburg, NJ US
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20150133667 | PROCESS FOR THE PREPARATION OF METHYLPHENIDATE AND PHARMACEUTICAL SALTS THEREOF - The present invention is directed to an improved process for the preparation of methylphenidate, stereoisomer, mixture of stereoisomers and pharmaceutically acceptable salts thereof, more particularly, the sulfate and hydrochloride salts of methylphenidate, di-threo-methylphenidate and dex-methylphenidate. Methods of removing or reducing the amount of impurities from the above described process are also disclosed. | 05-14-2015 |
20150133668 | PROCESS FOR THE PREPARATION OF METHYLPHENIDATE AND PHARMACEUTICAL SALTS THEREOF - The present invention is directed to an improved process for the preparation of methylphenidate, stereoisomer, mixture of stereoisomers and pharmaceutically acceptable salts thereof, more particularly, the sulfate and hydrochloride salts of methylphenidate, di-threo-methylphenidate and dex-methylphenidate. Methods of removing or reducing the amount of impurities from the above described process are also disclosed. | 05-14-2015 |