Patent application number | Description | Published |
20120034603 | LIGATION-BASED DETECTION OF GENETIC VARIANTS - The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides. | 02-09-2012 |
20120034685 | ASSAY SYSTEMS FOR DETERMINATION OF SOURCE CONTRIBUTION IN A SAMPLE - The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual. | 02-09-2012 |
20120040859 | ASSAY SYSTEMS FOR GENETIC ANALYSIS - The present invention provides assays systems and methods for detection of chromosomal abnormalities and status of single loci associated with monogenic or polygenic traits in a sample containing nucleic acids from a maternal and a fetal source. | 02-16-2012 |
20120077185 | DETECTION OF GENETIC ABNORMALITIES AND INFECTIOUS DISEASE - The present invention provides assay systems and related methods for detecting genetic abnormalities and infectious agents in maternal samples. Exemplary maternal samples for analysis using the assay systems of the invention include maternal blood, plasma or serum. | 03-29-2012 |
20120164646 | DETECTION OF GENETIC ABNORMALITIES - The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA and samples that contain DNA from normal cells and circulating cancerous cells. | 06-28-2012 |
20120190018 | ENHANCED RISK PROBABILITIES USING BIOMOLECULE ESTIMATIONS - The present invention provides processes for determining more accurate risk probabilities for medical conditions. The risk probabilities of the presence or absence of a medical condition are calculated using frequency data from selected biomolecules and biomolecule source contribution of at least one source in a mixed sample. | 07-26-2012 |
20120190020 | DETECTION OF GENETIC ABNORMALITIES - The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA and samples that contain DNA from normal cells and circulating cancerous cells. | 07-26-2012 |
20120190021 | DETECTION OF GENETIC ABNORMALITIES - The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA and samples that contain DNA from normal cells and circulating cancerous cells. | 07-26-2012 |
20120190557 | RISK CALCULATION FOR EVALUATION OF FETAL ANEUPLOIDY - The present invention provides processes for determining accurate risk probabilities for chromosome dosage abnormalities. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples. | 07-26-2012 |
20120191358 | RISK CALCULATION FOR EVALUATION OF FETAL ANEUPLOIDY - The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples. | 07-26-2012 |
20130004950 | ASSAY SYSTEMS FOR GENETIC ANALYSIS - The present invention provides assays systems and methods for detection of chromosomal abnormalities and status of single loci associated with monogenic or polygenic traits in a sample containing nucleic acids from a maternal and a fetal source. | 01-03-2013 |
20130040375 | ASSAY SYSTEMS FOR GENETIC ANALYSIS - The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual. | 02-14-2013 |
20130089863 | RISK CALCULATION FOR EVALUATION OF FETAL ANEUPLOIDY - The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples. | 04-11-2013 |
20130090250 | ASSAY SYSTEMS FOR GENETIC ANALYSIS - The present invention provides assays systems and methods for detection of chromosomal abnormalities and status of single loci associated with monogenic or polygenic traits in a sample containing nucleic acids from a maternal and a fetal source. | 04-11-2013 |
20130122500 | ASSAY SYSTEMS FOR GENETIC ANALYSIS - The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual. | 05-16-2013 |
20130143213 | DETECTION OF GENETIC ABNORMALITIES - The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA and samples that contain DNA from normal cells and circulating cancerous cells. | 06-06-2013 |
20130172211 | LIGATION-BASED DETECTION OF GENETIC VARIANTS - The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides. | 07-04-2013 |
20130172212 | LIGATION-BASED DETECTION OF GENETIC VARIANTS - The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides. | 07-04-2013 |
20130172213 | LIGATION-BASED DETECTION OF GENETIC VARIANTS - The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides. | 07-04-2013 |
20130210640 | ASSAY SYSTEMS FOR GENETIC ANALYSIS - The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual. | 08-15-2013 |
20130261003 | LIGATION-BASED DETECTION OF GENETIC VARIANTS - The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation—e.g., the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides—combined with detection of levels of particular genomic regions using array hybridization. | 10-03-2013 |
20130288252 | ASSAY SYSTEMS FOR GENETIC ANALYSIS - The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual. | 10-31-2013 |
20140095136 | MATHEMATICAL NORMALIZATION OF SEQUENCE DATA SETS - The invention provides processes of the present invention provide normalization procedures for sequences within multiplexed data sets using the sequence information from multiplexed sequencing data set itself rather than the utilization of any external references. | 04-03-2014 |
Patent application number | Description | Published |
20110289506 | MANAGEMENT OF COMPUTING RESOURCES FOR APPLICATIONS - The subject matter of this disclosure can be implemented in, among other things, a method. In these examples, the method includes receiving a resource request message to obtain access to a computing resource, and storing the resource request message in a data repository that stores a collection of resource request messages received from a group of applications executing on the computing device. The method may also include responsive to determining that the resource request message received from the first application has a highest priority of the collection of resource request messages, determining whether a second application currently has access to the computing resource, issuing a resource lost message to the second application to indicate that the second application has lost access to the computing resource, and issuing a resource request granted message to the first application, such that the first application obtains access to the computing resource. | 11-24-2011 |
20120023503 | MANAGEMENT OF COMPUTING RESOURCES FOR APPLICATIONS - The subject matter of this disclosure can be implemented in, among other things, a method. In these examples, the method includes receiving a resource request message to obtain access to a computing resource, and storing the resource request message in a data repository that stores a collection of resource request messages received from a group of applications executing on the computing device. The method may also include responsive to determining that the resource request message received from the first application has a highest priority of the collection of resource request messages, determining whether a second application currently has access to the computing resource, issuing a resource lost message to the second application to indicate that the second application has lost access to the computing resource, and issuing a resource request granted message to the first application, such that the first application obtains access to the computing resource. | 01-26-2012 |
20130257709 | Proximity Sensing for Wink Detection - This disclosure relates to proximity sensing for wink detection. An illustrative method includes receiving data from a receiver portion of a proximity sensor. The receiver portion is disposed at a side section of a head-mountable device (HMD). When a wearer wears the HMD, the receiver portion is arranged to receive light reflected from an eye area of the wearer, the proximity sensor detects a movement of the eye area, and the data represents the movement. The method includes determining that the data corresponds to a wink gesture. The method also includes selecting a computing action to perform, based on the wink gesture. The method further includes performing the computing action. | 10-03-2013 |
Patent application number | Description | Published |
20120109728 | INCENTIVES FOR MEDIA SHARING - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing incentives for media sharing. In one aspect, a method includes receiving a request from a first user to share a media item with a second user, and providing the second user with access to the media item. The method includes determining that the second user has performed an action related to the media item, and in response to determining that the second user has performed the action related to the media item, accessing a referral attribute associated with the first user, the referral attribute being related to the action. The method includes comparing the referral attribute to a reference value, based on comparing the referral attribute to the reference value, determining an amount of referral credit, and providing the determined amount of referral credit to the first user. | 05-03-2012 |
20120109904 | Media File Storage - Methods, systems and program products for replacing a master media file. Data indicates characteristics of a first user's multiple media files. At least one of the multiple media files matches content in a master media file. The content in the matching media file is of a second quality that is higher than the first quality of the master media file. A server system stores the matching media file in place of the master media file. The server system receives a request from a second user for content matching the master media file, and accesses quality parameters that indicate the second user can access a version of the content at a third quality that is less than the second quality. A media file that contains the requested content at the third quality is generated and sent to the second user. | 05-03-2012 |
20120109997 | Media File Storage - Methods, systems and program products for replacing a master media file. Data indicates characteristics of a first user's multiple media files. At least one of the multiple media files matches content in a master media file. The content in the matching media file is of a second quality that is higher than the first quality of the master media file. A server system stores the matching media file in place of the master media file. The server system receives a request from a second user for content matching the master media file, and accesses quality parameters that indicate the second user can access a version of the content at a third quality that is less than the second quality. A media file that contains the requested content at the third quality is generated and sent to the second user. | 05-03-2012 |
20120110126 | Loading a Mobile Computing Device with Media Files - In general, the subject matter described in this specification can be embodied in methods, systems, and program products for loading media files to a mobile computing device. A media library that includes media files is stored at a server system. Information indicating a present state of the mobile device is accessed, where the present state is based on the device being at a geographical location at a present time. Information indicating a previous state of the mobile device is accessed, where the previous state is based on the device being at a previous geographical location at a previous time. A selection of preferred media files are accessed based on the present state and the previous state. A selection of a subset of media files are accessed based on the preferred media files. At least a portion of each media file in the subset is transmitted to the mobile device. | 05-03-2012 |
20120110135 | Loading a Mobile Computing Device with Media Files - In general, the subject matter described in this specification can be embodied in methods, systems, and program products for loading media files to a mobile computing device. A media library that includes media files is stored at a server system. Information indicating a present state of the mobile device is accessed, where the present state is based on the device being at a geographical location at a present time. Information indicating a previous state of the mobile device is accessed, where the previous state is based on the device being at a previous geographical location at a previous time. A selection of preferred media files are accessed based on the present state and the previous state. A selection of a subset of media files are accessed based on the preferred media files. At least a portion of each media file in the subset is transmitted to the mobile device. | 05-03-2012 |
20120123838 | INCENTIVES FOR MEDIA SHARING - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing incentives for media sharing. In one aspect, a method includes receiving a request from a first user to share a media item with a second user, and providing the second user with access to the media item. The method includes determining that the second user has performed an action related to the media item, and in response to determining that the second user has performed the action related to the media item, accessing a referral attribute associated with the first user, the referral attribute being related to the action. The method includes comparing the referral attribute to a reference value, based on comparing the referral attribute to the reference value, determining an amount of referral credit, and providing the determined amount of referral credit to the first user. | 05-17-2012 |
20120124171 | MEDIA FILE ACCESS - A server system stores media library associated with a user. The media library includes at least one media file. The server system determines whether the media file is stored on a second computing device that is able to send the media file to the first computing device across a local network connecting the first computing device and the second computing device. If the determination indicates that the media file is stored on a second computing device that is able to send the stored media file to the first computing device across a local network connecting the first computing device and the second computing device, the server system sends causes the second computing device to send the media file to the first computing device across the local network such that the first computing device is able to output the media file to the user. | 05-17-2012 |
20120124172 | Providing Different Versions of a Media File - Data indicates characteristics of a user's multiple media files. The multiple media files are associated with a media library. At least one of the multiple media files matches content in a master media file. The content in the matching media file is of a quality that is lower than the quality of the master media file. The user can provide payment for access to the master media file and, if the user does so, the master media file is associated with the media library and the user is provided with access to the master media file. | 05-17-2012 |
20120124177 | Providing Different Versions of a Media File - Data indicates characteristics of a user's multiple media files. The multiple media files are associated with a media library. At least one of the multiple media files matches content in a master media file. The content in the matching media file is of a quality that is lower than the quality of the master media file. The user can provide payment for access to the master media file and, if the user does so, the master media file is associated with the media library and the user is provided with access to the master media file. | 05-17-2012 |
20120124178 | MEDIA FILE ACCESS - A server system stores media library associated with a user. The media library includes at least one media file. The server system determines whether the media file is stored on a second computing device that is able to send the media file to the first computing device across a local network connecting the first computing device and the second computing device. If the determination indicates that the media file is stored on a second computing device that is able to send the stored media file to the first computing device across a local network connecting the first computing device and the second computing device, the server system sends causes the second computing device to send the media file to the first computing device across the local network such that the first computing device is able to output the media file to the user. | 05-17-2012 |
Patent application number | Description | Published |
20100087706 | Lead Access - The present invention discloses various methods and systems for positioning a guide wire between a patient's mouth and a skin site via an implant tract in a stomach. The method includes locating the desired tissue site in the stomach, such as with an endoscope or other suitable instrument. In some embodiments the desired tissue site is marked inside the stomach with a visible dye or light visible from the peritoneal cavity. An implant tract is created through the stomach wall at the desired tissue site, either from “inside-out” or “outside-in”. The implant tract may be made using a RF catheter, RF guide wire, an endoneedle, or other suitable instrument. The size of the implant tract depends on the device to be placed there, such as a stimulation lead. Diameter sizes of the tract may vary from 0.014″ to 0.250″. An access hole or access port is created at a skin site, using a Verres needle, RF catheter, RF guide wire, an endoneedle, or other suitable instrument. A guide wire is then positioned through the implant tract, access port and mouth, such that the guide wire extends between the mouth and the skin site access port via the implant tract in the stomach. | 04-08-2010 |
20110166582 | Endoscopic Device Delivery System - A system and method are disclosed for an implantable gastric stimulation system within the stomach. The stimulation system includes an electronics anchor, electrode lead anchor, implantable pulse generator and external programmer. The electronics anchor is configured to attach to the stomach wall at a first location and the electrode lead anchor configured to attach to the stomach wall at a second location. The electrode lead anchor includes one or more electrodes configured to contact the stomach wall and a flexible lead portion coupled to the one or more electrodes at one end with an the electrical connector portion at the other end. The implantable pulse generator has electronic circuitry and is attached to the electronics anchor; the electronic circuitry is connected to the electrical connector of the electrode lead anchor and can communicate with the one or more electrodes. The external programmer is used to communicate with the electronic circuitry of the pulse generator via a telemetry device to provide stimulation instructions to the pulse generator. | 07-07-2011 |
20130035681 | NOVEL CATHETER FOR CONTIGUOUS RF ABLATION - A tissue ablation device comprising an elongate member having a proximal end, a distal end and a side wall defining a lumen, and an elongate ablation member having an ablation element proximate a distal end thereof, the elongate ablation member rotatable about an longitudinal axis of the elongate member, and wherein one of the elongate ablation member and the elongate member is at least partially contained within the other and methods of use therefor. | 02-07-2013 |
Patent application number | Description | Published |
20090054868 | Uterine Therapy Device and Method - A method and system of providing therapy to a patient's uterus. The method includes the steps of inserting an access tool through a cervix and a cervical canal into the uterus; actively cooling the cervical canal; delivering vapor through the access tool lumen into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; an active cooling mechanism adapted to cool the cervical canal, the active cooling mechanism having a coolant source; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus. | 02-26-2009 |
20090054869 | Uterine Therapy Device and Method - A method and system of providing therapy to a patient's uterus. In some embodiments the method includes the steps of: inserting an access tool through a cervix and a cervical canal into the uterus; placing an expansion mechanism in contact with tissue within the uterus to move uterine tissue surfaces away from an opening in an access tool lumen; delivering vapor through the vapor delivery tool into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool adapted to be inserted through a human cervical canal to place an opening of an access tool lumen within a uterus when the access tool is inserted through the cervical canal; an expansion mechanism adapted to be advanced into the uterus to move uterine tissue surfaces away from the opening in the access tool lumen; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus. | 02-26-2009 |
20090054870 | Uterine Therapy Device and Method - A method and system of providing therapy to a patient's uterus. The method include the following steps: inserting an access tool through a cervix and a cervical canal into the uterus; after inserting the access tool into the uterus, inserting a vapor delivery tool through an access tool lumen; delivering vapor through the vapor delivery tool into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool, the access tool being adapted to be inserted through a human cervical canal to place an opening of the access tool lumen within a uterus when the access tool is inserted through the cervical canal; and a vapor delivery mechanism, the vapor delivery mechanism having a vapor delivery tool and a vapor source, the vapor delivery tool being adapted to be inserted through the access tool to deliver condensable vapor from the vapor source to the uterus, the condensable vapor being adapted to condense within the uterus. | 02-26-2009 |
20090054871 | Uterine Therapy Device and Method - A method and system of providing therapy to a patient's uterus. The method includes the following steps: inserting an access tool through a cervix and a cervical canal into the uterus; after inserting the access tool into the uterus, creating a seal between an exterior surface of the access tool and an interior cervical os; providing an indication to a user that the seal has been created; delivering vapor through the access tool lumen into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; a seal disposed at a distal region of the access tool and adapted to seal the access tool against an interior cervical os; a sealing indicator adapted to provide a user with an indication that the seal has sealed the access tool with the interior cervical os; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus. | 02-26-2009 |
Patent application number | Description | Published |
20090018606 | Methods and Devices for Stimulation of an Organ with the Use of a Transectionally Placed Guide Wire - Devices, systems and methods are provided for electrical stimulation of a body organ, particularly within the gastrointestinal tract. In preferred embodiments, the stomach is the organ within the gastrointestinal tract which is targeted for such stimulation. A guide wire or other delivery device is positioned within the body so as to transect the stomach wall. Devices and systems are then advanced over the guide wire for attachment to the stomach wall. The guide wire may be placed by endoscopic, open, laparoscopic or a modified percutaneous approach. In a modified percutaneous approach, the stomach is accessed without the use of general anesthesia by advancing a needle through the abdomen, transecting the stomach wall with the needle and advancing the guide wire through the needle. In some embodiments, particularly for use in obese patients, the modified percutaneous approach includes advancing a trocar through the tissue of the patient toward the outer surface of the organ and advancing the needle through the trocar prior to transecting the wall with the needle. | 01-15-2009 |
20090030475 | Gastric Stimulation Systems and Methods Utilizing a Transgastric Probe - Gastric stimulation devices, systems and methods are provided, particularly for stimulating a gastric organ having an internal cavity. Such devices and systems are typically implanted outside of the gastric organ while the environment of the internal cavity is probed and monitored by one or more sensors. The sensor information may be used to affect the stimulation signals provided to the gastric organ by the devices and systems. Such feedback integration assists in providing treatments and stimulation programs that are tailored to the needs of the individual patient. | 01-29-2009 |
20090125010 | Uterine Therapy Device and Method - A method and system of providing therapy to a patient's uterus. In some embodiments the method includes the steps of: inserting an access tool through a cervix and a cervical canal into the uterus; placing an expansion mechanism in contact with tissue within the uterus to move uterine tissue surfaces away from an opening in an access tool lumen; delivering vapor through the vapor delivery tool into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool adapted to be inserted through a human cervical canal to place an opening of an access tool lumen within a uterus when the access tool is inserted through the cervical canal; an expansion mechanism adapted to be advanced into the uterus to move uterine tissue surfaces away from the opening in the access tool lumen; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus. | 05-14-2009 |
20120283717 | Uterine Therapy Device and Method - A method and system of providing therapy to a patient's uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; a seal disposed at a distal region of the access tool and adapted to seal the access tool against an interior cervical os; a sealing indicator adapted to provide a user with an indication that the seal has sealed the access tool with the interior cervical os; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus. | 11-08-2012 |
20130066312 | ABLATION DEVICE WITH MULTIPLE ABLATION MODES - Devices, systems, and methods for performing ablation therapy on body tissue are disclosed. An example ablation device for treating body tissue includes an ionically conductive balloon and a radio-frequency electrode that delivers RF energy into a distal section of the balloon. The balloon is configured to transmit the RF energy in a direction distally towards a leading end of the ablation device. Multiple ablation electrodes on the device can be used for providing lesions of different size or shape. | 03-14-2013 |
20130066315 | ABLATION DEVICE WITH IONICALLY CONDUCTIVE BALLOON - Devices, systems, and methods for performing ablation therapy on body tissue are disclosed. An example ablation device for treating body tissue includes an ionically conductive balloon and a radio-frequency electrode that delivers RF energy into a distal section of the balloon. The balloon can have a composite structure with a non-conductive section and a conductive section. A method for fabricating a semi-permeable ablation balloon using ionizing radiation and an etching process is also disclosed. | 03-14-2013 |
20140088503 | CATHETER SYSTEM INCLUDING AN EMBOLISM PROTECTION DEVICE - The present invention relates to a device for the prevention of air embolisms during a catheterization procedure. The device includes a bulb element configured to secure to a sheath assembly. The bulb element includes a flexible wall, including a proximal section and a distal section, and an interior chamber in fluid communication with a pressurized fluid source. The proximal section of the bulb element includes a proximal hub, and the distal section of the bulb element includes a distal hub. The bulb element is collapsible, under the action of an external force, from a first, relaxed state in which the interior chamber has a first volume, to a second, collapsed state in which the interior chamber has a second volume less than the first volume, and wherein the bulb element is configured to assume its first, relaxed state in the absence of the external force. | 03-27-2014 |