Patent application number | Description | Published |
20140350230 | MULTI-FUNCTIONAL NUCLEIC ACID-BASED ANTI-CANCER DRUG CAPABLE OF TARGETING AND THERAPY, METHOD FOR PREPARING SAME AND ANTI-CANCER COMPOSITION COMPRISING SAME - The present invention relates to a multi-functional nucleic acid-based anti-cancer drug in which the anti-cancer drug is physically bound to a linear nucleic acid having a thiol group at 5′ terminal thereof and then gold nanoparticles and aptamers are chemically bound. The present invention also relates to a method for preparing the anti-cancer drug and to an anti-cancer composition comprising the anti-cancer drug. The multi-functional nucleic acid-based anti-cancer drug according to the present invention uses A10 aptamer to achieve high targeting properties, and uses high-concentration anti-cancer drugs and gold nanoparticles to enable dual therapy of thermal therapy/chemical therapy, and may have less side effects and be more effective in anti-cancer therapy compared to existing anti-cancer drugs. | 11-27-2014 |
20140364596 | ARTIFICIAL LIPID-POLYMER-DNA COMPLEX, BIOIMAGING AGENT AND PREPARATION METHOD THEREOF - An artificial lipid-polymer-DNA complex, an in-vivo imaging agent, a pharmaceutical composition and a method of preparing the same are provided. The artificial lipid bilayer includes a polymer matrix including polylactic-co-glycolic acid disposed within a lipid membrane. | 12-11-2014 |
20150050698 | DEVELOPMENT OF NUCLEIC ACID GEL MATRIX FOR CELL-FREE PROTEIN SYNTHESIS OF CELL NUCLEUS REPLICATE, AND METHOD FOR PRODUCING SAME - Provided are a nucleic acid gel matrix for the cell-free protein synthesis of a cell nucleus replicate that contains an X-type nucleic acid nanostructure, an expression plasmid containing a DNA fragment, transcription and translation constituents, and a lipid membrane component, and a method for producing same. The nucleic acid gel matrix for the cell-free synthesis of a cell nucleus replicate is a polymorphic gel matrix that contains the X-type nucleic acid nanostructure, the expression plasmid containing the DNA fragment, the transcription and translation constituents, and the lipid membrane component. | 02-19-2015 |
20150104501 | LIPID-SUPPORTED POLYMERIC FUNCTIONAL PARTICLES AND METHOD OF PRODUCING THE SAME - The present disclosure relates to functional composite particles produced by filling water-soluble or lipid-soluble polymers into changeable liposomes and a method of producing the same. The present disclosure also relates to an evaluation of specialized biochemical characteristics of composites after the composites are produced using the water-soluble or lipid-soluble polymers by selection from groups capable of combining with lipid layers. A protocol according to an embodiment of the present disclosure overcomes the limitations of a conventional water/oil-based single emulsion protocol to prepare single polymer particles or single lipid layered particles and combine liposomes with a variety of polymer groups. | 04-16-2015 |
20150202328 | ARTIFICIAL LIPID-POLYMER-DNA COMPLEX, BIOIMAGING AGENT AND PREPARATION METHOD THEREOF - An artificial lipid-polymer-DNA complex, an in-vivo imaging agent, a pharmaceutical composition and a method of preparing the same are provided. The artificial lipid bilayer includes a polymer matrix including polylactic-co-glycolic acid disposed within a lipid membrane. | 07-23-2015 |
20150274768 | METHOD OF PREPARING BASE SEQUENCE OF 5'-COHESIVE END FOR SYNTHESIZING BRANCHED NUCLEIC ACID NANOSTRUCTURE - A method of preparing a base sequence for synthesis of a nucleic acid nanostructure, a method of synthesizing a nucleic acid nanostructure, a candidate base sequence pair, and a nucleic acid nanostructure are provided. A method of preparing a base sequence includes selecting candidate groups of base sequences of 5′-cohesive end having at least 50% GC content, calculating Gibb's free energy values of the selected candidate groups to re-select the candidate groups, and selecting the candidate groups, that have a sequence of 3 different successive bases among the base sequences from the re-selected candidate groups. | 10-01-2015 |
20150283075 | CORE-SHELL NANOPARTICLE INCLUDING NUCLEIC ACID HYDROGEL AND METHOD OF PRODUCING THE SAME - The present invention relates to a functional complex particle prepared by filling a nucleic acid hydrogel inside a liposome and a method of producing the same. The present invention may have an effect of increasing an expression of protein factors included in the particle by incorporating an X-shaped nucleic acid monomer in the nucleic acid hydrogel. Accordingly, when the core-shell particle is prepared using the method according to an embodiment of the present invention, an effect of facilitating an introduction of a genome into the nucleic acid hydrogel may be obtained, and thereby the core-shell particle may be used as a protein production platform copying a cell nucleus. | 10-08-2015 |
20150297682 | METHOD OF TREATING CANCER USING HIGH EFFICIENCY SELF-ILLUMINATIVE NANOCOMPLEXES AND METHOD OF MANUFACTURING THE SAME - The present disclosure relates to a method of treating cancer using a composition including a target-specific self-illuminative nanocomplex which includes an self-illuminative nanocomplex including a quantum dot and a modified self-illuminative protein (m-Rluc8), a targeted cancer-specific molecule and a hydrophilic polymer, and a method of preparing the composition. | 10-22-2015 |