Patent application number | Description | Published |
20100107646 | SHAPE MEMORY ALLOY ACTUATED ADAPTIVE EXHAUST NOZZLE FOR JET ENGINE - The proposed adaptive exhaust nozzle features an innovative use of the shape memory alloy (SMA) actuators for actively control of the opening area of the exhaust nozzle for jet engines. The SMA actuators remotely control the opening area of the exhaust nozzle through a set of mechanism. An important advantage of using SMA actuators is the reduction of weight of the actuator system for variable area exhaust nozzle. Another advantage is that the SMA actuator can be activated using the heat from the exhaust and eliminate the need of other energy source. A prototype has been designed and fabricated. The functionality of the proposed SMA actuated adaptive exhaust nozzle is verified in the open-loop tests. | 05-06-2010 |
20110288405 | DEVICE, SYSTEM, AND METHOD FOR A STRESS SENSING MEDICAL NEEDLE - In an embodiment, an apparatus comprises a needle (e.g., hypodermic needle or trocar) and sensor (e.g., fiber Braggs grating sensor) coupled to a system to determine (e.g., in real time) stress and/or vibrations encountered by the needle. Consequently, various embodiments may (a) help identify nearby vessels, (b) determine whether the needle penetrated a hollow body structure, and (c) accurately guide needles towards a target structure (e.g., vessel). Other embodiments are described herein. | 11-24-2011 |
20120017581 | SHAPE MEMORY ALLOY POWERED HYDRAULIC ACCUMULATOR HAVING WIRE GUIDES - A system, in certain embodiments, includes an accumulator having a first plate with a first wire guide and a second plate with a second wire guide. The second plate is positioned at an offset from the first plate, and the second plate is moveable relative to the first plate to adjust a fluid pressure. The accumulator also includes a plurality of shape memory alloy wires extending between the first and second plates, wherein the plurality of shape memory alloy wires extend along the first and second wire guides. | 01-26-2012 |
20120017582 | SHAPE MEMORY ALLOY POWERED HYDRAULIC ACCUMULATOR HAVING WIRE CLAMPS - A system, in certain embodiments, includes an accumulator having a first plate, a second plate positioned at an offset from the first plate, and a shape memory alloy wire extending between the first and second plates from a first wire portion to a second wire portion. The shape memory alloy wire is configured to move the first or second plate to adjust a fluid pressure in response to an electrical current through the shape memory alloy wire. The accumulator also includes a wire clamp assembly coupled to the first wire portion and/or the second wire portion of the shape memory alloy wire. | 01-26-2012 |
20120017583 | SHAPE MEMORY ALLOY POWERED HYDRAULIC ACCUMULATOR HAVING ACTUATION PLATES - A system, in certain embodiments, includes an accumulator having a first plate with a first plurality of holes and a second plate with a second plurality of holes. The second plate is positioned at an offset from the first plate, and the second plate is moveable relative to the first plate to adjust a fluid pressure. The accumulator also includes a plurality of shape memory alloy wires extending between the first and second plates, wherein the plurality of shape memory alloy wires extend through the first and second plurality of holes. | 01-26-2012 |
20120018415 | SELF-HEATING CONCRETE USING CARBON NANOFIBER PAPER - Electric, self-heating concrete systems that uses embedded carbon macrofiber or nanofibers paper as electric resistance heating elements are disclose. The self-heating concrete systems may utilize the conductive properties of carbon macrofiber or nanofiber materials to heat a surface overlay of concrete with various admixtures to improve the concrete's thermal conductivity. The self-heating concrete systems allow concrete roadways or the like to be heated to above freezing temperatures in a freezing environment in a reasonable amount of time. | 01-26-2012 |
20120019216 | ACTUATION OF SHAPE MEMORY ALLOY MATERIALS USING ULTRACAPACITORS - A system, in certain embodiments, includes a power supply. The power supply includes an ultracapacitor configured to be charged by a DC source. The power supply also includes a first switch that enables charging of the ultracapacitor by the DC source when in a closed position and disables charging of the ultracapacitor when in an open position. The power supply further includes a second switch configured to enable discharging of the ultracapacitor when in a closed position and to disable discharging of the ultracapacitor when in an open position. As the ultracapacitor is discharged, a current is supplied to actuate a shape memory alloy element. | 01-26-2012 |
20120103739 | POUNDING TUNE MASS DAMPER WITH VISCOELASTIC MATERIAL - A vibration dampener, including, a first beam comprising a first mounting end portion and a first peripheral end portion, wherein the first peripheral end portion comprises a tunable mass, and the first beam is configured to vibrate in tune with a vibrational frequency of a structure supporting the first beam at the first mounting end portion, a second beam comprising a second mounting end portion and a second peripheral end portion, wherein the second peripheral end portion comprises a ring disposed about the first beam, and a viscoelastic material disposed between the first beam and the ring, wherein the viscoelastic material is configured to dampen vibrational energy as the first beam vibrates toward the ring until the viscoelastic material becomes compressed between the first beam and the ring during the course of the impact. | 05-03-2012 |
20140066812 | System and Method for Monitoring the Health of Joints - A system and method for detecting lubrication conditions, lubrication regimes, impingement, stick-slip, and/or surface damage allows the health of a joint to be monitored. The system and method provides in situ or in vivo real-time monitoring of dynamic and static conditions of the joint. The monitoring system may use both passive and active sensing approaches that employ strategically placed piezoelectric transducers on/in the articulating components of the joint. In some embodiments, the transducers may be Lead Zirconate Titanate (PZT) transducers. Active sensing may be used to detect lubrication regimes under static and dynamic conditions. Passive sensing may be used to characterize the joint motion and abnormities, such as impingements and surface damages. | 03-06-2014 |
20140069908 | SYSTEMS AND METHODS FOR HEATING CONCRETE STRUCTURES - A system and method for heating concrete structures to either prevent the build-up of freezing precipitation or eliminate freezing precipitation on a top surface of the concrete structures. The system includes a heating assembly integrally formed with a concrete structure to apply thermal energy to the top surface of the concrete structure. Optionally, the heating assembly includes heating elements formed of carbon fiber tape. Following formation of the concrete structure, the heating assembly is configured for unified movement with the concrete structure. The system optionally includes a control assembly operatively coupled to the heating assembly. The control assembly selectively powers the heating assembly and can be configured for remote operation. In use, the control assembly can be selectively activated from a remote location to power the heating assembly and heat the concrete structure. | 03-13-2014 |
20140102190 | FIBER BRAGG GRATING SYSTEMS AND METHODS FOR MOISTURE DETECTION - A fiber Bragg grating (FBG) sensor for detecting moisture may include a sensor housing, FBG cable, water-swellable bead(s), and retaining mechanism. The housing secures the FBG cable and water-swellable bead. The retaining mechanism, such as one or more wire(s), placed adjacent to the FBG cable may be utilized to minimize lateral displacement of the water-swellable bead(s). The water-swellable bead(s) may swell as they absorb water, thereby causing the FBG to be strained to allow the detection of liquid moisture. | 04-17-2014 |
20140111231 | SYSTEMS AND METHODS UTILIZING CARBON NANOFIBER AGGREGATE FOR PERFORMANCE MONITORING OF CONCRETE STRUCTURES - A carbon nanofiber aggregate (CNFA) system and method provides self-sensing capabilities that can be used to detect strain, moisture, and temperature changes. The CNFA may include cement, aggregate, silica fume, high-range water reducer (HRWR), and/or carbon nanofibers. The metal meshes in the CNFA may be utilized to monitor the electric properties of the CNFA to detect strain, moisture, and temperature changes. The CNFA may be embedded in concrete structures to allow detection of strain, moisture, and temperature changes that may cause damage to structures. Several metal meshes may be embedded in the CNFA. | 04-24-2014 |
20140131562 | DYNAMIC FIBER BRAGG GRATING INTERROGATION SYSTEM AND METHOD - A fiber Bragg grating (FBG) interrogation method allows for high frequency dynamic measurement. The method may utilize a broad band light source connected to the sensing elements. Each sensing element may comprise two wavelength matching FBGs, a coupler, and a photodiode. The FBG closest to the light source may attenuate the central wavelength in the transmission spectrum and thus the reflection spectrum of the second FBG. Variations in intensity of the second FBG may be measured by the photodiode and can be calibrated to the desired measurands. | 05-15-2014 |
20140182381 | Gate Valve Real Time Health Monitoring System, Apparatus, Program Code and Related Methods - Systems, apparatus, and program code, and methods for monitoring the health and other conditions of the valve, are provided. An exemplary system for monitoring the condition of the gate valve includes a logic module configured to perform the operations of receiving sensor data providing an acoustic emission, vibration, and/or stream level signature and determining the level of lubricity, level of friction, level of surface degradation, and leakage rate at a gate-valve seat interface. An exemplary method for monitoring the condition of the gate valve includes receiving sensor data providing an acoustic emission, vibration, and/or stream level signature and determining the level of lubricity, level of friction, level of surface degradation, and leakage rate at a gate-valve seat interface. | 07-03-2014 |
20140262656 | POUNDING TUNE MASS DAMPER SYSTEMS AND CONTROLS - A vibration dampener, including, a first beam comprising a first mounting end portion and a first peripheral end portion, wherein the first peripheral end portion comprises a tunable mass, and the first beam is configured to vibrate in tune with a vibrational frequency of a structure supporting the first beam at the first mounting end portion, a second beam comprising a second mounting end portion and a second peripheral end portion, wherein the second peripheral end portion comprises a ring disposed about the first beam, and a viscoelastic material disposed between the first beam and the ring, wherein the viscoelastic material is configured to dampen vibrational energy as the first beam vibrates toward the ring until the viscoelastic material becomes compressed between the first beam and the ring during the course of the impact. | 09-18-2014 |
20140299801 | MAGNETORHEOLOGICAL FLUID DEVICE - A system, including a flow control system, including a valve, a first cylinder including a piston coupled to the valve, wherein the piston moves axially within the first cylinder to transition the valve between open and closed positions, a magnetorheological (MR) fluid within the first cylinder configured to axially move the piston, and an MR fluid device configured to magnetize the MR fluid to control axial movement of the piston. | 10-09-2014 |
Patent application number | Description | Published |
20130094134 | PROTECTIVE HINGE COVER FOR A MOBILE COMPUTING DEVICE - Embodiments of the present invention disclose a protective hinge cover for a mobile computing device. According to one embodiment, the protective hinge cover includes an inner cavity area for receiving the mobile device along with a rotatable attachment member formed therein. In addition, a plurality of coupling features are utilized to facilitate attachment of the hinge cover with the mobile computing device. Moreover, the rotatable attachment member and housing frame are configured to provide a movable and stable structure for the mobile computing and also allow for adjustment by an operating user so as to provide multiple viewing angles via a hinge mechanism associated with the rotatable attachment member. | 04-18-2013 |
20130235234 | DIGITAL CAMERA HAVING MULTIPLE IMAGE CAPTURE SYSTEMS - A digital camera system providing two different image capture systems, comprising a camera body including a first surface having an image display; a second surface opposite to the first surface; a third surface transverse to the first and second surfaces and having a smaller surface area than the first and second surfaces; and a fourth surface opposite to the third surface. A first image capture system has a first optical axis directed outward from the second surface, and a second image capture system has an optical axis directed outward from the third surface. Camera mounts are provided on the fourth and first or second surfaces to facilitate mounting the digital camera system such that either the first optical axis or the second optical axis can be oriented in a substantially horizontal direction. | 09-12-2013 |
20130286551 | FOLDABLE ELECTRONIC DEVICES INCLUDING A FIRST AND A SECOND MAGNET - Foldable electronic devices including a first and a second magnet. An example foldable electronic device includes a base, a cover, a hinge pivotally connecting the base and the cover to fold the device into a closed position, a first magnet in the base, and a second magnet in the cover to repel the first magnet to separate the base and the cover when the device is resting in the closed position. | 10-31-2013 |
20140029183 | STYLUS AND HOLDER DEVICE ASSOCIATED THEREWITH - Embodiments of the present invention disclose a stylus and stylus holder for a computing device. According to one embodiment, the stylus holder includes a connector configured to attach to a port of the computing device for establishing an electrical connection therewith. The stylus holder further includes a fastener for facilitating attachment with the stylus while also providing at least one of data and power to said stylus. | 01-30-2014 |
20140083997 | COVER ASSEMBLY FOR A PORTABLE ELECTRONIC DEVICE - Embodiments of the present invention disclose a cover assembly for a portable electronic device. According to one embodiment, a first cover element includes a first attachment feature and is formed to cover a first part of a rear surface of a portable electronic device, while a second cover element is formed to cover a second part of the rear surface of the portable electronic device and includes a second attachment feature configured to mate with the first attachment feature. Furthermore, the first attachment feature of the first cover element and the second attachment feature of the second cover element are configured to engage along a common edge so as to form a secure attachment in which the first cover element and second cover element cover the entire rear surface of the portable electronic device. | 03-27-2014 |
20150097980 | Digital Camera Having Multiple Image Capture Systems - A digital camera system having a digital camera and a remote control module is disclosed. The digital camera includes an image capture system, memory and wireless modem. The remote control module includes another wireless modem (to communicate with the digital camera's wireless modem), first and second user controls and a status display. One of the user controls can (via the wireless modems) cause the camera to capture an image. The other user control can cause the digital camera (via the wireless modems) to deliver camera status information which can then be displayed on the remote control module's status display. | 04-09-2015 |
Patent application number | Description | Published |
20090026548 | Systems And Methods For Fabricating Nanometric-Scale Semiconductor Devices With Dual-Stress Layers Using Double-Stress Oxide/Nitride Stacks - Systems and methods for fabricating semiconductor devices with dual-stress layers using double-stress oxide/nitride stacks. A method comprises providing NMOS and PMOS regions, selectively forming a dual-stack tensile stress layer over the NMOS region by depositing a tensile silicon nitride layer over the NMOS and PMOS regions, depositing a tensile silicon oxide layer over the tensile silicon nitride layer, removing a portion of the tensile silicon oxide layer from the PMOS region, and removing a portion of the tensile silicon nitride layer from the NMOS region and selectively forming a dual stack compressive stress layer over the PMOS region by depositing a compressive silicon nitride layer over the NMOS and PMOS regions, depositing a compressive silicon oxide layer over the compressive silicon nitride layer, removing a portion of the compressive silicon oxide layer from the NMOS region, and removing a portion of the compressive silicon nitride layer from the NMOS region. | 01-29-2009 |
20090294867 | DUAL METAL GATES USING ONE METAL TO ALTER WORK FUNCTION OF ANOTHER METAL - Methods of forming dual metal gates and the gates so formed are disclosed. A method may include forming a first metal (e.g., NMOS metal) layer on a gate dielectric layer and a second metal (e.g., PMOS metal) layer on the first metal layer, whereby the second metal layer alters a work function of the first metal layer (to form PMOS metal). The method may remove a portion of the second metal layer to expose the first metal layer in a first region; form a silicon layer on the exposed first metal layer in the first region and on the second metal layer in a second region; and form the dual metal gates in the first and second regions. Since the gate dielectric layer is continuously covered with the first metal, it is not exposed to the damage from the metal etch process. | 12-03-2009 |
20100109086 | Method of Fabricating A Fin Field Effect Transistor (FinFET) Device - A method of fabricating a semiconductor using a fin field effect transistor (FINFET) is disclosed. In a particular embodiment, a method includes depositing, on a silicon substrate, a first dummy structure having a first sidewall and a second sidewall separated by a first width. The method also includes depositing, on the silicon substrate, a second dummy structure concurrently with depositing the first dummy structure. The second dummy structure has a third sidewall and a fourth sidewall that are separated by a second width. The second width is substantially greater than the first width. The first dummy structure is used to form a first pair of fins separated by approximately the first width. The second dummy structure is used to form a second pair of fins separated by approximately the second width. | 05-06-2010 |
20100172173 | System And Method To Read And Write Data A Magnetic Tunnel Junction Element - A system and method to read and write data in magnetic random access memories are disclosed. In a particular embodiment, a device includes a spin transfer torque magnetic tunnel junction (STT-MTJ) element and a transistor with a first gate and a second gate coupled to the STT-MTJ element. | 07-08-2010 |
20100308408 | Apparatus and Method to Fabricate an Electronic Device - An apparatus and method to fabricate an electronic device is disclosed. In a particular embodiment, an apparatus includes a template having an imprint surface. The imprint surface includes a first region having a first pattern adapted to fabricate a fin field effect transistor (FinFET) device and a second region having a second pattern adapted to fabricate a planar electronic device. | 12-09-2010 |
20100324850 | Static Noise Margin Estimation - In a particular embodiment, a method is disclosed that estimates a total static noise margin of a bit cell of a memory. The method includes determining a correlation coefficient of a left static noise margin of the bit cell as compared to a right static noise margin of the bit cell and estimating a total static noise margin of the bit cell by evaluating an analytical function based on the correlation coefficient. | 12-23-2010 |
20110051535 | Fin-Type Device System and Method - A fin-type device system and method is disclosed. In a particular embodiment, a method of fabricating a transistor is disclosed and includes forming a gate of a transistor within a substrate having a surface and forming a buried oxide (BOX) layer within the substrate and adjacent to the gate at a first BOX layer face. The method also includes forming a raised source-drain channel (“fin”), where at least a portion of the fin extends from the surface of the substrate, and where the fin has a first fin face adjacent a second BOX layer face of the BOX layer. | 03-03-2011 |
20110235406 | Low-Power 5T SRAM with Improved Stability and Reduced Bitcell Size - A 5 Transistor Static Random Access Memory (5T SRAM) is designed for reduced cell size and immunity to process variation. The 5T SRAM includes a storage element for storing data, wherein the storage element is coupled to a first voltage and a ground voltage. The storage element can include symmetrically sized cross-coupled inverters. A single access transistor controls read and write operations on the storage element. Control logic is configured to generate a value of the first voltage a write operation that is different from the value of the first voltage for a read operation. | 09-29-2011 |
20120256270 | DUAL METAL GATES USING ONE METAL TO ALTER WORK FUNCTION OF ANOTHER METAL - Methods of forming dual metal gates and the gates so formed are disclosed. A method may include forming a first metal (e.g., NMOS metal) layer on a gate dielectric layer and a second metal (e.g., PMOS metal) layer on the first metal layer, whereby the second metal layer alters a work function of the first metal layer (to form PMOS metal). The method may remove a portion of the second metal layer to expose the first metal layer in a first region; form a silicon layer on the exposed first metal layer in the first region and on the second metal layer in a second region; and form the dual metal gates in the first and second regions. Since the gate dielectric layer is continuously covered with the first metal, it is not exposed to the damage from the metal etch process. | 10-11-2012 |
Patent application number | Description | Published |
20150088660 | Device, System, and Method of Soliciting and Accepting Offers from Merchant Members of a Virtual Network - A user's need to purchase a service or a good is communicated to a commercial network. The commercial network includes a plurality of merchant members that offer services or goods for sale. A plurality of electronic channels of communication is established between the mobile computing device and respective electronic devices of a subset of the plurality of merchant members. Offers for the service or good needed by the user are received from the merchant members through the electronic channels of communication. The user accepts one of the offers from a selected merchant. Thereafter, the electronic channels of communication between the mobile computing device and the respective electronic devices of the rest of the merchant members are automatically terminated. Meanwhile, the electronic channel of communication between the mobile computing device and the electronic device of the selected merchant is maintained. | 03-26-2015 |
20150088672 | Device, System, and Method of Selecting, Displaying, and Purchasing Favorite Drinks of a User Within a Location-Based Virtual Social Networking Context - A method of selecting, displaying, and purchasing favorite drinks of a user within a location-based virtual social networking context is disclosed. A mobile computing device of a first user is used to perform a digital check-in to a venue that is within a physical proximity of the first user. After the digital check-in, a digital menu that contains a list of drinks available at the venue is accessed. The digital menu is displayed to the first user via a screen of the mobile computing device. In response to selection from the first user, one or more drinks from the digital menu are designated as preferred drinks of the first user. The first user's preference of the one or more drinks is electronically communicated to another electronic device. | 03-26-2015 |
20150089396 | Device, System, and Method of Identifying a specific user from a profile image containing multiple people - The present disclosure involves a method. A request is received from a user to participate in an electronic social network. In response to the receiving of the request, a user is prompted to upload a digital picture that is representative of the user. An uploaded digital picture is uploaded in response to the prompting. The uploaded digital picture of the user is scanned for human faces. The user is prompted to upload a different digital picture that is representative of the user if the scanning indicates that the uploaded digital picture contains no human faces. The user is prompted to identify the human face belonging to the user if the scanning indicates that the uploaded digital picture contains a plurality of human faces. | 03-26-2015 |
20150089398 | Device, System, and Method of Selecting Favorite Users From An Electronic Virtual Social Network - A method of selecting favorite users from an electronic virtual social network is disclosed. A mobile computing device of a first user is used to perform a digital check-in to a venue within a predefined proximity of the first user. Other users have already digitally checked into the venue. On a screen of the mobile computing device of the first user, respective digital profiles of a first subset of the other users are displayed. In response to input from the first user, one or more second users who are within the first subset of the other users are designated as favorite users. On the screen of the mobile computing device of the first user, respective digital profiles of a second subset of the other users are displayed. The second subset of the other users includes the designated favorite user and users who are not within the first subset. | 03-26-2015 |
20150089660 | Device, System, and Method of Enhancing User Privacy and Security Within a Location-Based Virtual Social Networking Context - A first mobile computing device of a first user receives a request to participate in a location-based virtual social network. A radio component of the first mobile computing device detects venues within proximity of the first mobile computing device. Each venue includes a host of a respective virtual social network. One of the venues is selected by the user for participation in the virtual social network. A wireless connection with the virtual social network is established at the selected venue. Electronic communications with second users are conducted at the selected venue. The second users are also participants of the virtual social network. A departure of the first user from the selected venue is detected. In response to the detected departure, electronic records pertaining to the conducted electronic communications with the one or more second users are erased from the first mobile computing device. | 03-26-2015 |
Patent application number | Description | Published |
20090232753 | Gel compositions - A gel, comprising: an ester and a polymer having at least one of the following rigid block groups; polystyrene, polyethylene, polyvinyl chloride, and phenolics as well as one elastic block that is a member of the group consisting of ethylene/butadiene copolymers, polyisoprene, polybutadiene, ethylene/propylene copolymers, or ethylene-propylene/diene copolymers, wherein the polymer is either triblock copolymers, star polymers, radial polymers, multi-block copolymers, or combinations thereof, wherein the composition is substantially free of mineral oils; wherein the ester's chemical formula is: | 09-17-2009 |
20110045983 | Gel composition - A gel, comprising: an ester and a polymer having at least one of the following rigid block groups; polystyrene, polyethylene, polyvinyl chloride, and phenolics as well as one elastic block that is a member of the group consisting of ethylene/butadiene copolymers, polyisoprene, polybutadiene, ethylene/propylene copolymers, or ethylene-propylene/diene copolymers, wherein the polymer is either triblock copolymers, star polymers, radial polymers, multi-block copolymers, or combinations thereof, wherein the composition is substantially free of mineral oils; wherein the ester's chemical formula is: | 02-24-2011 |
20110178348 | HYDROCARBON COMPOSITIONS USEFUL AS LUBRICANTS - A process for the preparation of a synthetic predominantly single carbon number hydrocarbon fluid comprises the steps of: contacting an alpha olefin having a carbon number of 4 to 30 with a single site catalyst under conditions effective to produce reactive hydrocarbon oligomers that contain reactive double bonds and comprising predominantly dimers, trimers, and tetramers wherein at least 10 weight percent of such reactive hydrocarbon oligomers at least one of trimers and tetramers; separating at least one of said trimers and tetramers in said reactive hydrocarbon oligomers; dimerizing said separated one of said trimers tetramers by contacting said separated one of said trimers or tetramers with a dimerization catalyst thereby producing an unsaturated synthetic hydrocarbon fluid; and contacting said unsaturated synthetic hydrocarbon fluid with hydrogen in the presence of a hydrogenation catalyst thereby producing a synthetic hydrocarbon fluid having predominantly single carbon number. | 07-21-2011 |
20120302480 | ADDITIVE CONCENTRATE - The present invention provides an additive concentrate comprising: − at least 90 wt. % of a Fischer-Tropsch derived base oil, based on the total weight of the additive concentrate; − at least 3.0 wt. % of a viscosity modifier, based on the total weight of the additive concentrate; and − less than 5.0 wt. % of a solvency booster, based on the total weight of the additive concentrate. | 11-29-2012 |
20150232149 | Jumping drive device - A non-motorized scooter with jumping drive device taking the advantages of scooter and pogo-stick. It has two models: | 08-20-2015 |
Patent application number | Description | Published |
20080318906 | BISPHOSPHONATE COMPOUNDS AND METHODS FOR BONE RESORPTION DISEASES, CANCER, BONE PAIN, IMMUNE DISORDERS, AND INFECTIOUS DISEASES - Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as | 12-25-2008 |
20100316676 | Bisphosphonate Compounds and Methods for Bone Resorption Diseases, Cancer, Bone Pain, Immune Disorders, and Infectious Diseases - Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as | 12-16-2010 |
20120022024 | ANTI-BACTERIAL COMPOSITIONS AND METHODS INCLUDING TARGETING VIRULENCE FACTORS OF STAPHYLOCOCCUS AUREUS - This disclosure relates to compositions and methods including for the inhibition, prevention, and/or treatment of microbial infections, including infections from such pathogens as | 01-26-2012 |
20120329842 | SMALL MOLECULE COMPOUNDS AS BROAD-SPECTRUM INHIBITORS OF METALLO-BETA-LACTAMASES - The present invention concerns methods and/or compositions for treatment and/or prevention of bacterial infection wherein the bacteria has at least one metallo-β-lactamase. The bacteria are provided with an inhibitor of the metallo-β-lactamase, for example in conjunction with an antibiotic that targets the bacteria. The bacteria may be a drug-resistant strain or susceptible to becoming a drug-resistant strain. In specific embodiments, the bacteria is | 12-27-2012 |
20130065857 | NOVEL DXR INHIBITORS FOR ANTIMICROBIAL THERAPY - The present invention generally concerns particular methods and compositions for antimicrobial therapy. In particular embodiments, the compositions target DXR. In specific embodiments, the compositions are electron-deficient heterocyclic rings. | 03-14-2013 |
20140100184 | SELECTIVE INHIBITORS OF HISTONE METHYLTRANSFERASE DOT1L - Structure and mechanism based design was used to design potent ribose containing inhibitors of DOT1L with IC | 04-10-2014 |
20140154302 | ANTIMICROBIAL COMPOSITIONS FOR TREATING MICROBIAL INFECTIONS - The disclosure provides compounds and methods to treat a microbial or a bacterial pathogenesis, and demonstrates that the | 06-05-2014 |
20150065466 | NOVEL DXR INHIBITORS FOR ANTIMICROBIAL THERAPY - The present invention generally concerns particular methods and compositions for antimicrobial therapy. In particular embodiments, the compositions target DXR. In some cases, the antimicrobial agent comprises an electron-deficient hydrophobic group that has interacts with Trp211 of DXR. In specific embodiments, the compound contains electron-deficient heterocyclic rings that specifically interact with the electron-rich indole ring of Trp211. In certain aspects, the compositions comprise a phosphate group, a pyridine group, and a hydroxymate group. | 03-05-2015 |