Patent application number | Description | Published |
20080293627 | Thyrotropin Receptor Preparations, Binding Regions Thereof, Antibody and Hormone Interactions Therewith, and Uses Thereof - A mutated TSHR preparation which includes at least one point mutation characterised in that at least amino acid Arg at a position corresponding to amino acid 255 of a full length human TSHR has been mutated to a different amino acid residue in said mutated TSHR preparation, whereby said mutated TSHR preparation differentially interacts with patient serum stimulating TSHR autoantibodies, patient serum blocking TSHR autoantibodies and TSH, in that (i) the stimulatory effect of patient serum stimulating TSHR autoantibodies interacting with the mutated TSHR preparation is substantially reduced or essentially abolished, when compared to the stimulatory effect of the patient serum stimulating TSHR autoantibodies interacting with a reference TSHR preparation which has an amino acid sequence corresponding to that of said mutated TSHR preparation with the exception that said mutation of Arg at a position corresponding to amino acid 255 of a full length human TSHR is not present in said reference TSHR preparation, (ii) the stimulatory effect of TSH when interacting with the mutated TSHR preparation is essentially unaffected, when compared to the stimulatory effect of TSH interacting with said reference TSHR preparation, and (iii) the blocking effect of patient serum blocking TSHR autoantibodies interacting with the mutated TSHR preparation is essentially unaffected or increased, when compared to the blocking effect of the patient serum blocking TSHR autoantibodies interacting with said reference TSHR preparation, whereby said mutated TSHR preparation is effective in the differential screening and identification of patient serum stimulating TSHR autoantibodies, patient serum blocking TSHR autoantibodies and TSH in a sample of body fluid being screened. | 11-27-2008 |
20090202438 | EPITOPE REGIONS OF A THYROTROPHIN (TSH) RECEPTOR, USES THEREOF AND ANTIBODIES THERETO - The present invention is concerned with epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto. | 08-13-2009 |
20090203036 | EPITOPE REGIONS OF A THYROTROPHIN (TSH) RECEPTOR, USES THEREOF AND ANTIBODIES THERETO - The present invention is concerned with epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto. | 08-13-2009 |
20100233189 | Crystal structure - This invention relates to a crystallisable composition comprising a TSHR polypeptide, to crystals comparing a TSHR polypeptide and to TSHR-related applications. | 09-16-2010 |
20110300138 | HUMAN ANTI TSHR ANTIBODIES - According to one aspect there is provided an isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on TSHR constitutive activity, wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR. | 12-08-2011 |
20120225955 | DETECTION OF AUTOANTIBODIES REACTIVE WITH PANCREATIC ISLET CELL ANTIGENIC MOLECULES AND/OR INSULIN - A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules (GAD, 1A2) and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method. After addition of the sample one or more complexes comprising `antigenic molecule of fist source!-`analyte auto antibody!-`antigenic molecule of second source! The antigenic molecule of first source is immobilised to a solid phase, the second is labeled. | 09-06-2012 |
20130089561 | EPITOPE REGIONS OF A THYROTROPHIN (TSH) RECEPTOR, USES THEREOF AND ANTIBODIES THERETO - The present invention is concerned with epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto. | 04-11-2013 |
20150344582 | HUMAN ANTI TSHR ANTIBODIES - According to one aspect there is provided An isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on TSHR constitutive activity wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR. | 12-03-2015 |
Patent application number | Description | Published |
20130260477 | BIOLOGICAL SAMPLE STORAGE DEVICE - Embodiments of the invention relate to methods of assembling an apparatus for holding biological samples. Conventionally, storage media are encased in a relatively thin flexible cardboard frame. Such constructions are vulnerable to damage from moisture and mechanical forces; these defects may subsequently cause problems for automated handling systems. In an embodiment, these defects are prevented by providing a pair of rigid frames, each frame comprising an aperture; placing a biological sample storage medium between the two frames so that the biological sample storage medium at least partly overlaps each of the apertures in the frames; and joining the two frames to fix the biological sample storage medium in place while allowing access to the biological sample storage medium via each of the apertures. Thus, in embodiments of the present invention, the frames can be rigid and waterproof, and provide a robust storage media for biological samples. At least one pre-defined area of weakness can be provided in the frames, to allow removal of a portion of the frames. | 10-03-2013 |
20130323715 | CONTAINER STORING FREEZE-DRIED BIOLOGICAL SAMPLE - Embodiments of the invention relate to a container holding, and a method of storing, freeze-dried biological samples. In particular, there is provided a container holding a freeze-dried material comprising a biological sample, the container comprising a chamber having an upper portion and a lower portion, the chamber comprising a wall and the lower portion being fluidly connected to the upper portion such that, when liquid is received at the upper portion, the received liquid can pass to and accumulate in the lower portion. Further, the freeze-dried material is located in the lower portion, and the container comprises a physical structure in the form of a stop protruding inwards from the wall, the physical structure being for inhibiting the freeze-dried material from moving from the lower portion of the chamber to the upper portion of the chamber. This ensures that the biological sample can be kept in a lower portion of the tube, ensuring that, when the biological sample is subsequently reconstituted by inserting water, substantially all of the biological sample is dissolved. | 12-05-2013 |
20140011289 | ARRANGEMENT FOR PRESERVATION OF BIOLOGICAL SAMPLES - The invention relates to an arrangement for drying of biological samples on a sample storage substrate, comprising at least one sample storage substrate holder and at least one chemical heat pad. | 01-09-2014 |
20140154686 | BIOMETRIC DEVICE AND MEANS FOR ELECTRONIC STORAGE AND RETRIEVAL OF BIOMETRIC DATA - There is disclosed a biometric device ( | 06-05-2014 |