Patent application number | Description | Published |
20080292559 | Method of treating tuberculosis with interferons - A method of treating | 11-27-2008 |
20090123422 | Method of treating idiopathic pulmonary fibrosis with aerosolized IFN-y - A method of treating idiophathic pulmonary fibrosis (IPF), comprising administering aerosolized interferon-γ in a therapeutically effective amount to achieve improved or ameliorated symptoms of IPF. | 05-14-2009 |
20100015062 | Method of treating pulmonary disease with interferons - A method of treating a pulmonary disease such as, for instance idiophathic pulmonary fibrosis (IPF), mixed connective tissue disease and asthma, comprising administering an aerosolized interferon such as interferon γ in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) alone or in combination with other therapeutic agents are provided. | 01-21-2010 |
20100098660 | Method of treating tuberculosis with interferons - A method of treating tuberculosis comprising administering an aerosolized interferon such as interferon α, interferon β or interferon γ in a therapeutically effective amount is provided herein. Further, a method of reducing the infectivity of tuberculosis or reducing the number of infectious organisms present in the lungs of a patient suffering from tuberculosis comprising administering an aerosolized interferon such as interferon α, interferon β or interferon γ in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) are provided. | 04-22-2010 |
20120183499 | Method of treating pulmonary disease with interferons - A method of treating a pulmonary disease such as, for instance idiopathic pulmonary fibrosis (IPF), mixed connective tissue disease and asthma, comprising administering an aerosolized interferon such as interferon γ in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) alone or in combination with other therapeutic agents are provided. | 07-19-2012 |
20120219523 | Method of treating tuberculosis with interferons - A method of treating tuberculosis comprising administering an aerosolized interferon such as interferon α, interferon β or interferon γ in a therapeutically effective amount is provided herein. Further, a method of reducing the infectivity of tuberculosis or reducing the number of infectious organisms present in the lungs of a patient suffering from tuberculosis comprising administering an aerosolized interferon such as interferon α, interferon β or interferon γ in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) are provided. | 08-30-2012 |
20130233325 | FACE MASK FOR DEFLECTING RESPIRATORY AEROSOLS GENERATED BY THE WEARER - A facemask to be worn in an enclosed space by a subject having or suspected of having a disease transmitted in exhaled aerosol particles is provided. The facemask comprises an air-permeable body having an outer surface facing away from the face of the subject, an inner surface facing toward the face, an upper edge cephalad, a lower edge caudad, and lateral edges at each side of the face such that the inner surface covers the subject's nose and mouth and is spaced apart therefrom. Moreover, at least a portion of the upper and lower edges is spaced apart from the face, but the lateral edges are not spaced apart. The upward and downward deflection of aerosol plumes exiting the facemask cooperates with airflow in the enclosed space to reduce exposure of occupants of the space to the subject's exhaled aerosol particles. | 09-12-2013 |
Patent application number | Description | Published |
20100041766 | Medthods, Devices And Formulations For Targeted Endobronchial Therapy - The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen. | 02-18-2010 |
20110059044 | Method of treating pulmonary disease with interferons - A method of treating a pulmonary disease such as, for instance idiophathic pulmonary fibrosis (IPF) and asthma, comprising administering an aerosolized interferon such as interferon α, interferon β or interferon γ in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) are provided. | 03-10-2011 |
20120148532 | Method of treating pulmonary disease with interferons - A method of treating a pulmonary disease such as, for instance idiophathic pulmonary fibrosis (IPF) and asthma, comprising administering an aerosolized interferon such as interferon α, interferon β or interferon γ in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) are provided. | 06-14-2012 |
20130298904 | Methods, Devices And Formulations For Targeted Endobronchial Therapy - The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen. | 11-14-2013 |
20140014103 | Methods, Devices and Formulations for Targeted Endobronchial Therapy - The present invention provides a method and novel devices for treating tracheobronchitis and pneumonia in the intubated patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In a preferred embodiment, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The devices eliminate the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen. | 01-16-2014 |
20140053830 | Methods, Devices And Formulations For Targeted Endobronchial Therapy - The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen. | 02-27-2014 |
Patent application number | Description | Published |
20100140854 | Impact-Attenuation Systems for Articles of Footwear and Other Foot-Receiving Devices - Impact-attenuation members, e.g., for use in footwear or other foot-receiving devices, include: (a) a first body member having a base region and three (or more) leg portions extending from the base region. A second body member, with similar leg portions, may be arranged facing the first member such that the free ends of the various leg portions lie adjacent one another. A retaining member may extend between and/or at least partially around the body members to at least partially hold them in place with respect to one another. Such impact-attenuation systems may be arranged in the heel (or other portions) of an article of footwear. | 06-10-2010 |
20100192407 | Impact-Attenuation Members and Products Containing Such Members - Impact-attenuation members include body portions, optionally with an arched structure, that define a base orientation and an open space; and a spring member extending across the open space and engaging the body portion(s). When a force is applied to the body portion(s) in at least some orientations and/or directions of incident force, e.g., so as to change the impact-attenuation member out of its base orientation, the spring member may exert a force that urges the impact-attenuation member back toward the base orientation. Various example structures for the impact-attenuation member are described. Such impact-attenuation members may be used in articles of footwear or other foot-receiving device products. | 08-05-2010 |
20100263227 | Impact-Attenuation Members With Lateral and Shear Force Stability and Products Containing Such Members - Impact-attenuation members include: (a) an impact-attenuating member and (b) a shear resistant member engaged with the impact-attenuating member. Another example impact-attenuation member includes a shear resistant member having a continuous wall that bulges outward on opposing sides when in an uncompressed base orientation. The shear resistant members may be structured and arranged to allow bending or compression against impact forces in one direction (e.g., when landing a step or a jump), but remain highly stable against shear or lateral forces in another direction (e.g., in a side-to-side direction). Such impact-attenuation members may be used in footwear products, including in athletic footwear. | 10-21-2010 |
20100307023 | Impact-Attenuation Systems For Articles Of Footwear And Other Foot-Receiving Devices - Impact-attenuation systems, e.g., for use in footwear, can help control foot positioning during a step cycle, e.g., to help reduce or eliminate misorientation of the foot, and the fatigue and/or strain that may result from such misorientation. Articles of footwear including such impact-attenuation systems may include: (a) an upper member; and (b) a sole structure engaged with the upper member. The sole structure may include: (i) a first impact-attenuating member located in a heel portion of the foot-supporting member, and (ii) a second, separate impact-attenuating member located at a rear, lateral heel portion. The second impact-attenuating member may be designed and/or configured to provide less resistance to an impact force as compared with the first impact-attenuating member. | 12-09-2010 |
20110005099 | Impact-Attenuation Systems For Articles Of Footwear And Other Foot-Receiving Devices - Impact-attenuation systems, e.g., for use in footwear, can help control foot positioning during a step cycle, e.g., to help reduce or eliminate misorientation of the foot, and the fatigue and/or strain that may result from such misorientation. Articles of footwear including such impact-attenuation systems may include: (a) an upper member; and (b) a sole structure engaged with the upper member. The sole structure may include: (i) a first impact-attenuating member located in a heel portion of the foot-supporting member, and (ii) a second, separate impact-attenuating member located at a rear, lateral heel portion. The second impact-attenuating member may be designed and/or configured to provide less resistance to an impact force as compared with the first impact-attenuating member. | 01-13-2011 |
20120119426 | Impact-Attenuation Systems for Articles of Footwear and Other Foot-Receiving Devices - Impact-attenuation members, e.g., for use in footwear or other foot-receiving devices, include: (a) a first body member having a base region and three (or more) leg portions extending from the base region. A second body member, with similar leg portions, may be arranged facing the first member such that the free ends of the various leg portions lie adjacent one another. A retaining member may extend between and/or at least partially around the body members to at least partially hold them in place with respect to one another. Such impact-attenuation systems may be arranged in the heel (or other portions) of an article of footwear. | 05-17-2012 |
20120167415 | Impact-Attenuation Members and Products Containing Such Members - Impact-attenuation members include body portions, optionally with an arched structure, that define a base orientation and an open space; and a spring member extending across the open space and engaging the body portion(s). When a force is applied to the body portion(s) in at least some orientations and/or directions of incident force, e.g., so as to change the impact-attenuation member out of its base orientation, the spring member may exert a force that urges the impact-attenuation member back toward the base orientation. Various example structures for the impact-attenuation member are described. Such impact-attenuation members may be used in articles of footwear or other foot-receiving device products. | 07-05-2012 |
20130097888 | IMPACT-ATTENUATION MEMBERS WITH LATERAL AND SHEAR FORCE STABILITY AND PRODUCTS CONTAINING SUCH MEMBERS - Impact-attenuation members include: (a) an impact-attenuating member and (b) a shear resistant member engaged with the impact-attenuating member. Another example impact-attenuation member includes a shear resistant member having a continuous wall that bulges outward on opposing sides when in an uncompressed base orientation. The shear resistant members may be structured and arranged to allow bending or compression against impact forces in one direction (e.g., when landing a step or a jump), but remain highly stable against shear or lateral forces in another direction (e.g., in a side-to-side direction). Such impact-attenuation members may be used in footwear products, including in athletic footwear. | 04-25-2013 |
20130097889 | IMPACT-ATTENUATION MEMBERS WITH LATERAL AND SHEAR FORCE STABILITY AND PRODUCTS CONTAINING SUCH MEMBERS - Impact-attenuation members include: (a) an impact-attenuating member and (b) a shear resistant member engaged with the impact-attenuating member. Another example impact-attenuation member includes a shear resistant member having a continuous wall that bulges outward on opposing sides when in an uncompressed base orientation. The shear resistant members may be structured and arranged to allow bending or compression against impact forces in one direction (e.g., when landing a step or a jump), but remain highly stable against shear or lateral forces in another direction (e.g., in a side-to-side direction). Such impact-attenuation members may be used in footwear products, including in athletic footwear. | 04-25-2013 |
20130097890 | IMPACT-ATTENUATION MEMBERS WITH LATERAL AND SHEAR FORCE STABILITY AND PRODUCTS CONTAINING SUCH MEMBERS - Impact-attenuation members include: (a) an impact-attenuating member and (b) a shear resistant member engaged with the impact-attenuating member. Another example impact-attenuation member includes a shear resistant member having a continuous wall that bulges outward on opposing sides when in an uncompressed base orientation. The shear resistant members may be structured and arranged to allow bending or compression against impact forces in one direction (e.g., when landing a step or a jump), but remain highly stable against shear or lateral forces in another direction (e.g., in a side-to-side direction). Such impact-attenuation members may be used in footwear products, including in athletic footwear. | 04-25-2013 |
20130104421 | IMPACT-ATTENUATION MEMBERS WITH LATERAL AND SHEAR FORCE STABILITY AND PRODUCTS CONTAINING SUCH MEMBERS | 05-02-2013 |
20130118033 | IMPACT ATTENUATING AND SPRING ELEMENTS AND PRODUCTS CONTAINING SUCH ELEMENTS - Impact attenuating/spring systems may include first and second body portions and at least one spring member at least partially included between the body portions. The spring member(s) may substantially enclose and/or be pivotally engaged with the body portion(s). The components of the impact attenuating and spring element may be arranged such that when a force is applied to the body portion(s), the spring member(s) will exert a counter force to urge the impact attenuating and spring element back toward its original orientation. The spring members may include one or more polymeric element that stretches under a tensile force. The impact attenuating and spring elements may be included in a piece of footwear or other device in a manner such that a user or a retailer (or others) can select an appropriate spring member (or portion thereof), e.g., depending on characteristics of the user or the intended use. | 05-16-2013 |
20130118034 | IMPACT ATTENUATING AND SPRING ELEMENTS AND PRODUCTS CONTAINING SUCH ELEMENTS - Impact attenuating/spring systems may include first and second body portions and at least one spring member at least partially included between the body portions. The spring member(s) may substantially enclose and/or be pivotally engaged with the body portion(s). The components of the impact attenuating and spring element may be arranged such that when a force is applied to the body portion(s), the spring member(s) will exert a counter force to urge the impact attenuating and spring element back toward its original orientation. The spring members may include one or more polymeric element that stretches under a tensile force. The impact attenuating and spring elements may be included in a piece of footwear or other device in a manner such that a user or a retailer (or others) can select an appropriate spring member (or portion thereof), e.g., depending on characteristics of the user or the intended use. | 05-16-2013 |
20130152428 | ARTICULATED SOLE STRUCTURE WITH REARWARDLY ANGLED MEDIOLATERAL MIDFOOT SIPES - A footwear sole structure may include a plurality of discrete sole elements defined by a plurality of sipes. The sipes may include a plurality of sipes that extend in a direction extending from a medial side of the sole structure to a lateral side of the sole structure and be rearwardly angled. Those sipes may be located in a midfoot region. The sole structure may include a plurality of additional sipes having longitudinal, transverse and other orientations. | 06-20-2013 |
20130160328 | Articles of Footwear - Articles of footwear, including athletic footwear, include cleat structures, strapping systems, sole structures, and/or improved natural motion characteristics are described. Also, methods for making such articles of footwear (and particularly sole structures for articles of footwear) are described. | 06-27-2013 |
20130326915 | IMPACT-ATTENUATION SYSTEMS FOR ARTICLES OF FOOTWEAR AND OTHER FOOT-RECEIVING DEVICES - Impact-attenuation systems, e.g., for use in footwear, can help control foot positioning during a step cycle, e.g., to help reduce or eliminate misorientation of the foot, and the fatigue and/or strain that may result from such misorientation. Articles of footwear including such impact-attenuation systems may include: (a) an upper member; and (b) a sole structure engaged with the upper member. The sole structure may include: (i) a first impact-attenuating member located in a heel portion of the foot-supporting member, and (ii) a second, separate impact-attenuating member located at a rear, lateral heel portion. The second impact-attenuating member may be designed and/or configured to provide less resistance to an impact force as compared with the first impact-attenuating member. | 12-12-2013 |
20130326916 | IMPACT-ATTENUATION SYSTEMS FOR ARTICLES OF FOOTWEAR AND OTHER FOOT-RECEIVING DEVICES - Impact-attenuation systems, e.g., for use in footwear, can help control foot positioning during a step cycle, e.g., to help reduce or eliminate misorientation of the foot, and the fatigue and/or strain that may result from such misorientation. Articles of footwear including such impact-attenuation systems may include: (a) an upper member; and (b) a sole structure engaged with the upper member. The sole structure may include: (i) a first impact-attenuating member located in a heel portion of the foot-supporting member, and (ii) a second, separate impact-attenuating member located at a rear, lateral heel portion. The second impact-attenuating member may be designed and/or configured to provide less resistance to an impact force as compared with the first impact-attenuating member. | 12-12-2013 |
20130326917 | IMPACT-ATTENUATION SYSTEMS FOR ARTICLES OF FOOTWEAR AND OTHER FOOT-RECEIVING DEVICES - Impact-attenuation systems, e.g., for use in footwear, can help control foot positioning during a step cycle, e.g., to help reduce or eliminate misorientation of the foot, and the fatigue and/or strain that may result from such misorientation. Articles of footwear including such impact-attenuation systems may include: (a) an upper member; and (b) a sole structure engaged with the upper member. The sole structure may include: (i) a first impact-attenuating member located in a heel portion of the foot-supporting member, and (ii) a second, separate impact-attenuating member located at a rear, lateral heel portion. The second impact-attenuating member may be designed and/or configured to provide less resistance to an impact force as compared with the first impact-attenuating member. | 12-12-2013 |
20140059882 | Article of Footwear with a Heating System - A heated article of footwear that includes an outer shell and a removable inner liner is described. The inner liner includes a heating system with a toe cap heating element. The toe cap heating element is disposed around a perimeter of the forefoot region of the inner liner. The heating system is integrated within the inner liner and is removable with the inner liner from the outer shell. A power source for the heating system is contained within a battery compartment area disposed along a cuff of the inner liner to provide access to the power source. | 03-06-2014 |
20140059894 | Article of Footwear with an Indicator for a Heating System - An indicator for a heated article of footwear that includes an outer shell and a removable inner liner is described. The inner liner includes a heating system with an indicator disposed on a forefoot region of the inner liner. The heating system is integrated within the inner liner and is removable with the inner liner from the outer shell. A viewing window is disposed on the outer shell at a location corresponding to the indicator located on the inner liner. With this arrangement, the status condition of the heating system on the inner liner may be communicated to a wearer of the article through the viewing window from within the interior of the article. | 03-06-2014 |
20140157625 | Article With Adjustable Stiffness Tongue - An article of footwear for snowboarding includes a tongue with adjustable stiffness. The tongue includes a flexible intermediate portion and the flexibility of the intermediate portion can be controlled by a tension control system. As the tension control system applies increased tension to the tongue, the flexibility of the intermediate portion is decreased, which increases the overall stiffness of the tongue. | 06-12-2014 |
20140157627 | Article Of Footwear With Adjustable Stiffness - An article of footwear with adjustable stiffness is provided. The article of footwear in the form of a snowboard boot is provided with adjustable tensioning systems that are disposed on either side of an inner liner of the snowboard boot. The adjustable tensioning system includes a comb body structure having flex portions made of a plurality of extending fingers with a flexibility that can be controlled by the adjustable tensioning system. Depending on the level of tension applied by the tensioning system, or lack thereof, a range of flex profiles having varying amounts of stiffness are available to the wearer to adjust the overall stiffness of the snowboard boot. | 06-12-2014 |
20150089836 | UPPERS AND SOLE STRUCTURES FOR ARTICLES OF FOOTWEAR - Sole structures and uppers for articles of footwear are described that includes features to enhance footwear flexibility, dexterity, natural motion feel, and/or tackiness. Such articles of footwear may provide enhanced properties and feel for use in skateboarding and other activities. | 04-02-2015 |
20150089841 | UPPERS AND SOLE STRUCTURES FOR ARTICLES OF FOOTWEAR - Sole structures and uppers for articles of footwear are described that includes features to enhance footwear flexibility, dexterity, natural motion feel, and/or tackiness. Such articles of footwear may provide enhanced properties and feel for use in skateboarding and other activities. | 04-02-2015 |