Patent application number | Description | Published |
20090273774 | Oil-immersion enhanced imaging flow cytometer - A flow chamber, imaging objective, condenser and imaging light source as part of an optical system includes an oil-immersion objective and high numerical aperture condenser matched to a rectangular flow chamber. The oil-immersion objective and flow chamber include a high index of refraction immersion oil so as to enhance the optical resolution and optical coupling therethrough. The imaging light source generates light which passes through the condenser, the flow chamber and then the objective before being focused onto an imaging camera. Fluorescence excitation passes through the objective to the flow chamber where the oil immersion configuration enhances the focus and collection of the light back through the objective. | 11-05-2009 |
20090283697 | SYSTEM AND METHOD FOR MONITORING BLUE-GREEN ALGAE IN A FLUID - A particle detection system with a detection mechanism that includes detectors positioned to detect two different ranges of fluorescence produced by particles in the fluid in a flow chamber. Each of the detectors is arranged to generating a trigger signal whenever fluorescence is detected. The system and related method enhance the accuracy and sensitivity of blue-green algae monitoring by utilizing imaging flow cytometry combined with particle analysis and the measurement of the ratio of each particle's phycocyanin to chlorophyll b detected by using the two detectors configured for detection of two different fluorescence ranges, one associated with the phycocyanin and the other associated with the chlorophyll b. Optionally, captured images may be used in comparison to known images of a library of images. | 11-19-2009 |
20120002029 | SYSTEM AND METHOD FOR SWEEPING MIRROR ENHANCED IMAGING FLOW CYTOMETRY - An imaging flow cytometry system and method which includes a flow chamber, tracking mirror, microscope and imaging optics, image capturing system, device to regulate fluid flow through the chamber, and backlighting generator. The tracking mirror moves at a rate matched to the particle velocity in the flow chamber so as to enhance the sample flow rates possible with the system while maintaining clear and accurate imaging. The backlighting generator passes through the flow chamber and the objective before being focused on the image capturing system. Detected scatter events initiate tracking by the mirror, resulting in imaging with reduced motion blur even at high rates of flow. | 01-05-2012 |
20120127298 | SYSTEM AND METHOD FOR MONITORING BIREFRINGENT PARTICLES IN A FLUID - An imaging system with an imaging mechanism which includes polarization analyzers, which may be crossed polarization analyzers, positioned to provide birefringence images of particles in the fluid passing through the flow chamber. Captured images are of high resolution and may be used in comparison to known images of a library of images. The system and related method enhance the accuracy and sensitivity of particle monitoring by utilizing birefringence imaging combined with particle analysis and the detection of each particle's characteristic features, such as crystalline features. The system includes a scatter detector used to trigger backlighting of the flow chamber and capture images of particles therein. | 05-24-2012 |
20120176616 | FLUID SUBMERSIBLE SENSING DEVICE - A fluid submersible sensing device is provided comprising a fluid-tight housing defining an internal chamber and including window structure; sensing structure provided in the internal chamber; light providing apparatus in the internal chamber emitting light capable of passing through the window structure so as to exit the housing; and a sample-providing structure coupled to the housing and located outside of the housing internal chamber comprising a passage through which a fluid flows. The passage may have a longitudinal axis substantially parallel with a flow path through the passage and a cross sectional area substantially transverse to the longitudinal axis. The light from the housing exits the housing, passes through the sample-providing structure including the passage and re-enters the housing toward the sensing structure. | 07-12-2012 |
20130315447 | SYSTEM AND METHOD FOR TOTAL INTERNAL REFLECTION ENHANCED IMAGING FLOW CYTOMETRY - An imaging flow cytometry system and method which includes a flow chamber, fluorescence analysis and imaging optics, image capturing system, device to regulate fluid flow through the chamber, and backlighting generator. The flow cell is configured so as to enhance the fluorescence signal collection by the system with total internal reflections. The fluorescence collection optics are configured to enhance the collection of the fluorescence from the side of the flow cell and concentrate it on light detectors. | 11-28-2013 |
Patent application number | Description | Published |
20090063977 | BODY REGION INDICATION - The invention is directed toward two-dimensional dynamic body image templates, and associated techniques, that allow a user to indicate regions of the human body. The body region indications may correspond to locations of injury, pain, treatment, discoloration, paresthesia, or the like. A user is presented with the body image templates and asked to indicate regions on the body templates that correspond to affected regions of a patient's body. The body image templates represent views of an external surface of a human body rotated about at least one axis. In exemplary embodiments, a user controls display of overlapping templates, which may allow the user to perceive rotation of a three-dimensional body surface. The user indicated regions from each of the displayed body image templates are stored in a body surface coordinate system, such that regions indicated via one template may be appropriately displayed on other templates. | 03-05-2009 |
20100016752 | SYSTEM AND METHOD FOR NEUROLOGICAL ACTIVITY SIGNATURE DETERMINATION, DISCRIMINATION, AND DETECTION - A system and method are provided for automatically correlating neurological activity to a predetermined physiological response. The system includes at least one sensor operable to sense signals indicative of the neurological activity, and a processing engine coupled to the sensor. The processing engine is operable in a first system mode to execute a simultaneous sparse approximation jointly upon a group of signals sensed by the sensor to generate signature information corresponding to the predetermined physiological response. The system further includes a detector coupled to the sensors, which is operable in a second system mode to monitor the sensed signals. The detector generates upon selective detection according to the signature information a control signal for actuating a control action according to the predetermined physiological response. | 01-21-2010 |
20110125221 | FAILSAFE PROGRAMMING OF IMPLANTABLE MEDICAL DEVICES - A watchdog unit receives stay-alive signals from a programming device during programming of an implantable medical device. The watchdog unit maintains a watchdog timer, and resets the timer upon receipt of each stay-alive signal. If the watchdog timer expires, the watchdog unit changes a mode of operation of the implantable device, e.g., places the implantable medical device into a known, safe state. For example, the watchdog unit may cause the implantable medical device to suspend delivery of therapy, perform a power-on reset, and/or recall a known, safe, therapy delivery program. | 05-26-2011 |
20110184493 | DISTRIBUTED SYSTEM FOR NEUROSTIMULATION THERAPY PROGRAMMING - A distributed system comprises a programming device and a remotely located server. During a programming session, the programming device transmits programs and rating information associated with the programs to the server. The server presents the rating information to a clinician to assist the clinician in selecting from among programs tested during the programming session. The programming device may also transmit patient information and device configuration information to the server for storage with selected programs and rating information within a database as part of a patient record. Programs and information received from a plurality of programming devices and for a plurality of patients may be stored in the database and analyzed by the server to provide responses to user queries made by clinicians via programming devices. | 07-28-2011 |
20110196455 | NEUROSTIMULATION THERAPY MANIPULATION - A user, such as a clinician or the patient, uses a control device to manipulate at least one neurostimulation parameter. A mapping system uses a calibrated map to map the directional output of the control device to values of at least one stimulation parameter to allow the user to intuitively control the value of the parameter. In some embodiments, where a stimulation device is used to deliver spinal cord stimulation (SCS) therapy for example, the user manipulates a parameter to effect the location and/or strength of paresthesia experienced by the patient. In exemplary embodiments, the parameter values are combinations of electrodes, and the mapping system selects electrode combinations based on the output of the control device such that a direction of movement of paresthesia experienced by the patient corresponds to a direction of manipulation of a directional controller of the control device. The mapping system may calibrate the map based on patient paresthesia information received from a user. | 08-11-2011 |
20110224950 | Indirect Monitoring of Device Usage and Activities - Signal characteristics, or signatures, defined by one or more forms of energy being transferred during the commission of an activity are captured in dimensionally-reduced numerical sequences. Dimensionality reduction is achieved such that reduced data acquired during a detection phase can be directly compared with such reduced data produced during system training. Activities, events, human identities and so on can be identified through such direct comparison. Dimensionality reduction, such as through sparse approximation or simultaneous sparse approximation, may produce combinations of scaled prototype functions. Such combinations or their parametric representations compactly describe the signal characteristics for purposes of discovering new activity signatures, of extracting test signals from a set of measurements and of comparing sets for purposes of detection and classification. | 09-15-2011 |
20110243476 | Inspection of Hidden Structure - An inspection apparatus determines information indicative of structure that may be hidden behind an obscuring boundary, such as a wall. A processor collects measurements of properties characterizing the hidden structure and measurements of location of the apparatus. The collected data are mapped to produce an image of intensity in the characteristic measurements. Each intensity value in the image reflects a measure of density, of material type, or of some other specific information by which hidden structure can be discerned. The intensity changes indicating the hidden structure are displayed to a user via color-coded pixels or the like. | 10-06-2011 |
20130073263 | SYSTEM AND METHOD FOR SIGNATURE AND EXTRACTION, DETECTION, DISCRIMINATION, AND LOCALIZATION - A system and method whereby acoustic signals can be classified and identified as to nature and location of the original signal. The system and method determine from an arbitrary set of signals a signature or other characterizing feature and distinguish signals associated with a plurality of conditions by means of dictionaries comprising atoms of signals. | 03-21-2013 |
20140222371 | INSPECTION OF HIDDEN STRUCTURE - An inspection apparatus determines information indicative of structure that may be hidden behind an obscuring boundary, such as a wall. A processor collects measurements of properties characterizing the hidden structure and measurements of location of the apparatus. The collected data are mapped to produce an image of intensity in the characteristic measurements. Each intensity value in the image reflects a measure of density, of material type, or of some other specific information by which hidden structure can be discerned. The intensity changes indicating the hidden structure are displayed to a user via color-coded pixels or the like. | 08-07-2014 |