Sherr, US
Alan B. Sherr, Cambridge, MA US
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20110248914 | System and Method for Virtual Touch Typing - Systems, methods, and products are described for enabling a user to enter data into a device without a keyboard. A virtual keyboard in accordance with the invention may include a sensor to detect actual or intended finger movements or other changes in the user's physiology, an element that generates a sequence of ambiguous pseudo-words based on the physiological changes, and a translator that translates the pseudo-words into words in a natural language and provides the natural language words to the device or to a data storage unit. The device typically may be a computer, electronic notepad, personal digital assistant, telephone, or other electronic device. | 10-13-2011 |
Daniel D. Sherr, Washington Depot, CT US
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20100114650 | COMPUTER-IMPLEMENTED, AUTOMATED MEDIA PLANNING METHOD AND SYSTEM - An automated computer system for media planning is provided. The automated computer system includes functionality for determining geographically-localized estimated sales data for use in generating media plans. The automated computer system also includes functionality for determining the relative value of a localized geography to a media plan. The automated computer system further includes functionality for a media buyable unit (MBU) score for use in generating a geographically-localized media plan. | 05-06-2010 |
20100114651 | COMPUTER-IMPLEMENTED, AUTOMATED MEDIA PLANNING METHOD AND SYSTEM - An automated computer system for scoring the effectiveness of a number of number of media options for purposes of media planning is provided. The system implements the following functions: receiving a client objective for a media plan for advertising a number of products and/or services and a consumer purchasing frequency for the number of products and/or services; receiving a number of media product options; and scoring the effectiveness of each of the number of media product options based on the client objective and the consumer purchasing frequency to obtain a value for each of the number of media product options. The client objective may be selected from a number of discrete objectives and the consumer purchasing frequency may be selected from a number of consumer purchasing frequency options. | 05-06-2010 |
20100114652 | COMPUTER-IMPLEMENTED, AUTOMATED MEDIA PLANNING METHOD AND SYSTEM - An automated computer system for generating a geographically-localized media plan including a number of selected media buyable units (MBUs) is provided. The system implements the following functions: receiving client-defined information and a number of business rules; receiving a number of MBUs each having a relative value and including a first and second MBU associated with a first media product option and a third and fourth MBU associated with a second media product option; applying an optimization algorithm to the client-defined information, the number of business rules and the number of MBU relative values to obtain a number of selected MBUs included in a geographically-localized media plan; and outputting the geographically-localized media plan for use by a client in media planning. The first MBU associated with a first geography. The second MBU is associated with a second geography and the first geography, with the first geography being larger than the second geography and the first geography substantially covering the second geography. | 05-06-2010 |
David Sherr, Moraga, CA US
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20090077269 | DISTRIBUTED COMPUTING SYSTEM ARCHITECTURE - A computing system architecture is based upon a peer-to-peer, asynchronous model. The architecture specifies a set of infrastructure facilities that comprise an inter-prise operating system. The inter-prise operating system provides all the facilities that make application coding as easy in the peer-to-peer asynchronous model as it is in a hierarchical, synchronous model. Services, which reside in containers, are linked asynchronously by an inter-prise bus and use data from a virtual data store. | 03-19-2009 |
David Sherr, Pleasant Hill, CA US
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20120265915 | DISTRIBUTED COMPUTING SYSTEM ARCHITECTURE - A computing system architecture is based upon a peer-to-peer, asynchronous model. The architecture specifies a set of infrastructure facilities that comprise an inter-prise operating system. The inter-prise operating system provides all the facilities that make application coding as easy in the peer-to-peer asynchronous model as it is in a hierarchical, synchronous model. Services, which reside in containers, are linked asynchronously by an inter-prise bus and use data from a virtual data store. | 10-18-2012 |
David H. Sherr, West Roxbury, MA US
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20090028847 | MULTIPLE MYELOMA AND AL AMYLOID IMMUNOTHERAPY TARGETING IMMUNOGLOBULIN LIGHT CHAINS AND USES THEREOF - The present invention relates generally to the prevention and treatment of disease states, and more particularly to the treatment and prevention of plasma cell disorders and plasma cell dyscrasias and other malignancies, amyloidosis and amyloid-associated diseases. In particular, the present invention relates to methods and compositions comprising immunogenic peptides for the treatment and prevention of diseases and malignancies, for example plasma cell disorders, plasma cell dyscrasias and amyloidosis or amyloid-associated diseases. The present invention also provides methods for an assay to screen for therapeutic vaccines for plasma cell disorders, plasma cell dyscrasias and amyloidosis or amyloid-associated diseases. | 01-29-2009 |
20130281525 | ARYL HYDROCARBON RECEPTOR (AhR) MODIFIERS AS NOVEL CANCER THERAPEUTICS - Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness. | 10-24-2013 |
20140050711 | PRODUCTION OF RED BLOOD CELLS AND PLATELETS FROM STEM CELLS - This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a stem cell into a MEP in culture in the presence of an aryl hydrocarbon receptor (AhR) agonist. In some embodiments the stem cell is a pluripotent stem cell. In some embodiments the MEP co-expresses CD41 and CD235. In some embodiments the number of MEPs produced in the culture increases exponentially. Methods of making a red blood cell (RBC) by culturing a MEP in the presence of an AhR agonist are also provided. Methods of making a megakaryocyte and/or a platelet, comprising culturing a MEP in the presence of an AhR modulator are also provided. In some embodiments the AhR modulator is an AhR antagonist. This disclosure also provides compositions comprising at least 1 million MEPs per ml and compositions in which at least 50% of the cells are MEPs. | 02-20-2014 |
Evan Sherr, Ashland, MA US
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20120310083 | SYSTEMS AND METHODS FOR MONITORING TIME BASED PHOTO ACTIVE AGENT DELIVERY OR PHOTO ACTIVE MARKER PRESENCE - Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system. | 12-06-2012 |
20130060187 | SYSTEMS AND METHODS FOR CORNEAL CROSS-LINKING WITH PULSED LIGHT - A method for controlling activation of Riboflavin applied to an eye includes applying the Riboflavin to a selected region of a cornea of the eye and initiating cross-linking activity in the selected region by activating the Riboflavin with pulsed light illumination. The pulsed light illumination has an irradiance, dose, and an on/off duty cycle. The irradiance, the dose, and the on/off duty cycle are adjusted in response to a determination of photochemical kinetic pathways for Riboflavin cross-linking activity and to control photochemical efficiency. | 03-07-2013 |
20130085370 | SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY - In systems and methods for generating cross-linking activity in an eye, a feedback system monitors a biomechanical strength of the eye in response to the photoactivation of a cross-linking agent applied to an eye. The feedback system includes a perturbation system that applies a force to the eye and a characterization system that determines an effect of the force on the eye. The effect of the force provides an indicator of the biomechanical strength of the eye. The characterization system determines the effect of the force on the eye by measuring an amount of deformation caused by the force or a rate of recovery from the deformation. | 04-04-2013 |
20130245536 | SYSTEMS AND METHODS FOR CORNEAL CROSS-LINKING WITH PULSED LIGHT - A method for controlling activation of a cross-linking agent applied to an eye includes applying the cross-linking agent to a selected region of a cornea of the eye and initiating cross-linking activity in the selected region by activating the cross-linking agent with pulsed light illumination. The pulsed light illumination has a selectable wavelength, irradiance, dose, and on/off duty cycle. The wavelength, the irradiance, the dose, and the on/off duty cycle are adjusted in response to a determination of photochemical kinetic pathways for cross-linking activity and to control photochemical efficiency, depth of cross-linking, and density of cross-linking. | 09-19-2013 |
20140343480 | SYSTEMS, METHODS, AND COMPOSITIONS FOR CROSS-LINKING - Various agents and additives for cross-linking treatments are identified in disclosed studies. The characteristics of the various agents and additives may be advantageously employed in formulations applied in cross-linking treatments of the eye. In some embodiments, riboflavin is combined with Iron(II) to enhance the cross-linking activity generated by the riboflavin. In other embodiments, cross-linking treatments employ an Iron(II) solution in combination with a hydrogen peroxide pre-soak. In yet other embodiments, 2,3-butanedione is employed to increase the efficacy of corneal cross-linking with a photosensitizer, such as riboflavin. In further embodiments, folic acid is employed in combination with a photosensitizer, such as riboflavin, to enhance cross-linking activity. In yet further embodiments, 2,3-butanedione, folic acid, a quinoxaline, a quinoline, dibucaine, Methotrexate, menadione, or a derivative thereof is applied as a cross-linking agent. | 11-20-2014 |
Evan A. Sherr, Ashland, MA US
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20090041666 | Ophthalmic formulations of Amyloid-beta contrast agent and methods of use thereof - The invention provides ophthalmic formulations of Amyloid-β contrast agents. Also provided are methods of using such formulations in the diagnosis of Alzheimer's Disease or a predisposition thereto as well as methods for the prognosis of Alzheimer's Disease. | 02-12-2009 |
20110080559 | Ocular Imaging - A system for performing quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and scattered by the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye. | 04-07-2011 |
20130114042 | Ocular Imaging - A system for performing quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and scattered by the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye. | 05-09-2013 |
Evan Andrew Sherr, Ashland, MA US
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20090054956 | MULTIPLE WAVELENGTH LASER WORKSTATION - Lasers capable of lasing at least two wavelengths are provided having a lasing medium which is capable of lasing at a first wavelength and at a second wavelength. An output coupler is positioned along a longitudinal axis at a first end of the lasing medium and a first mirror, movable beam block shutter and second mirror are positioned sequentially along the longitudinal axis of the lasing medium at a second end of the lasing medium. The first mirror is highly reflective at a first wavelength, and the second mirror is highly reflective at a second wavelength while being transparent at the first wavelength. The beam block shutter is movable between a first position along the longitudinal axis of the lasing medium and between the first and second mirrors and a second position away from the longitudinal axis of the lasing medium. Also provided are laser workstations having two lasers driven by a single electronics drive system in which a single energy storage network is connected to a first laser pump chamber operative to excite a first laser medium and connected to a second laser pump chamber operative to excite a second laser medium. In certain embodiments, a switch connects the single energy storage network to a secondary winding of a high voltage trigger transformer, which is itself connected to the laser pump chambers. These high voltage trigger transformer serve to selectively ionize the excitation source in one of the laser pump chambers such that when the switch is closed, energy from the energy storage network will flow through the pump chamber whose excitation source(s) has been previously ionized. In other embodiments, the single energy storage network is connected to the excitation sources via active semiconductor switches that permit the release of portions of energy stored in the single energy storage network to one of the lasers, leaving additional energy to be immediately or rapidly released to the excitation source of the first or another laser. Also provided are methods of treating skin having a skin problem using multiple wavelengths of laser energy. | 02-26-2009 |
20130296835 | MULTIPLE WAVELENGTH LASER WORKSTATION - Lasers capable of lasing at least two wavelengths are provided having a lasing medium which is capable of lasing at a first wavelength and at a second wavelength. Also provided are laser workstations having two lasers driven by a single electronics drive system in which a single energy storage network is connected to a first laser pump chamber operative to excite a first laser medium and connected to a second laser pump chamber operative to excite a second laser medium. Also provided are methods of treating skin having a skin problem using multiple wavelengths of laser energy. | 11-07-2013 |
Micah Sherr, Washington, DC US
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20120278633 | METHOD AND SYSTEM FOR MANAGING INFORMATION ON MOBILE DEVICES - A system and method for protecting information on a mobile device. The method and apparatus obtain a predetermined portion of asymmetric information upon an input of the asymmetric information in the mobile device; generate an identifier by using a first generating algorithm that uses the predetermined portion of the asymmetric information as an algorithm input; generate an encryption key by using a second generating algorithm that uses the predetermined portion of the asymmetric information as an algorithm input; generate ciphered information by using an encryption algorithm that uses the encryption key and the information as algorithm inputs; associate the identifier with the ciphered information; and store the ciphered information as associated with the identifier. | 11-01-2012 |
20140329499 | METHOD AND SYSTEM FOR MANAGING INFORMATION ON MOBILE DEVICES - A method and apparatus that protect information on a mobile device. The method and mobile device obtain a predetermined portion of asymmetric information upon an input of the asymmetric information in the mobile device; generate an identifier by using a first generating algorithm that uses the predetermined portion of the asymmetric information as an algorithm input; generate an encryption key by using a second generating algorithm that uses the predetermined portion of the asymmetric information as an algorithm input; generate ciphered information by using an encryption algorithm that uses the encryption key and the information as algorithm inputs; associate the identifier with the ciphered information; and store the ciphered information as associated with the identifier. | 11-06-2014 |