Patent application number | Description | Published |
20090264635 | METHODS AND COMPOSITIONS FOR DEPLETING ABUNDANT RNA TRANSCRIPTS - The present invention concerns a system for isolating, depleting, and/or preventing the amplification of a targeted nucleic acid, such as mRNA or rRNA, from a sample comprising targeted and nontargeted nucleic acids. | 10-22-2009 |
20110257039 | REVERSE TRANSCRIPTION PRIMERS AND METHODS OF DESIGN - The present invention provides novel algorithms for designing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other transcripts. Such oligonucleotides are particularly useful as primers for reverse transcription. The invention also provides compositions containing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other transcripts. | 10-20-2011 |
20110301343 | METHODS AND COMPOSITIONS FOR DEPLETING ABUNDANT RNA TRANSCRIPTS - The present invention concerns a system for isolating, depleting, and/or preventing the amplification of a targeted nucleic acid, such as mRNA or rRNA, from a sample comprising targeted and nontargeted nucleic acids. | 12-08-2011 |
20130059759 | REVERSE TRANSCRIPTION PRIMERS AND METHODS OF DESIGN - The present invention provides novel algorithms for designing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other transcripts. Such oligonucleotides are particularly useful as primers for reverse transcription. The invention also provides compositions containing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other transcripts. | 03-07-2013 |
20130189758 | RECOMBINANT REVERSE TRANSCRIPTASES - The present invention relates to a gene that encodes a hyperactive reverse transcriptase having DNA polymerase activity and substantially reduced RNase H activity, vectors containing the gene and host cells transformed with the invention. The present invention also includes a method of producing the hyperactive reverse transcriptase, producing cDNA from mRNA using the reverse transcriptase of the invention, kits and assay templates made using the hyperactive reverse transcriptase. | 07-25-2013 |
20130302810 | MODIFIED SURFACES AS SOLID SUPPORTS FOR NUCLEIC ACID PURIFICATION - The invention relates to methods of separating polynucleotides, such as DNA, RNA and PNA, from solutions containing polynucleotides by reversibly binding the polynucleotides to a solid surface, such as a magnetic microparticle. | 11-14-2013 |
20150031584 | REVERSE TRANSCRIPTION PRIMERS AND METHODS OF DESIGN - The present invention provides novel algorithms for designing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other transcripts. Such oligonucleotides are particularly useful as primers for reverse transcription. The invention also provides compositions containing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other transcripts. | 01-29-2015 |