Patent application number | Description | Published |
20100162208 | MODELING TOOL BUILDER - GRAPHICAL EDITOR CONSTRUCTION - A modeling tool may be created directed from a drawing. A plurality of components and their relationships are deduced from the drawing and defined as a metamodel. One or more user operations performed while creating the drawing are also determined and used in building the metamodel. The metamodel may be used in a fixed mode to create a model with definition of the metamodel. The metamodel may be also used in a flexible mode to further redefine the metamodel or create a second metamodel. | 06-24-2010 |
20110023044 | SCHEDULING HIGHLY PARALLEL JOBS HAVING GLOBAL INTERDEPENDENCIES - A method of scheduling highly parallel jobs with global interdependencies is provided herein. The method includes the following steps: grouping input elements, each group being associated with an interdependency tag reflecting a level of interdependency between data associated with different input elements within a group; clustering the groups into collections of groups, wherein the clustered groups are associated with an interdependency tag reflecting a level of interdependency between groups, above a specified value; applying a conflict check to the collections of groups and to active jobs of a working set, to yield a conflict level between each collection of groups and each active job, by analyzing the interdependency tags of the collections of groups vis à vis interdependency tags associated with the active jobs; and adding collections of groups into the working set, wherein added collections of groups are associated with a conflict level below an acceptable conflict level. | 01-27-2011 |
20140122613 | CROSS-DOMAIN COLLABORATIVE CONFIGURATION MANAGEMENT - A computerized method for cross-domain collaborative revision management of a common product. The method comprises: Monitoring a plurality of local revisions for each of a plurality of projects associated with the common product, each of the plurality of projects managed in one of a plurality of domain-specific configuration management tools; creating a collaborative baseline within a collaborative relationship hub synchronizing between a group of the plurality of local revisions selected from each of the plurality of projects; and assembling instructions of generating the common product according to the collaborative baseline. | 05-01-2014 |
20140201706 | CREATING PLUGGABLE ANALYSIS VIEWPOINTS FOR AN OPTIMIZATION SYSTEM MODEL - A method of creating a system having pluggable analysis viewpoints over a design space model based on templates for analytical representation of different system aspects, comprising:
| 07-17-2014 |
20140324393 | CROSS-DOMAIN DATA ARTIFACTS CONSOLIDATION IN MODEL CONTEXT - A computerized method for consolidating data artifacts across domains in a context of an engineering reference model, said method comprising: generating a unified model data index by indexing a plurality of elements of a plurality of data artifacts, wherein said plurality of data artifacts describe a plurality of engineering and non-engineering domains; creating an engineering reference model describing said plurality of engineering and non-engineering domains; enriching said unified model data index by adding a plurality of relations between a plurality of elements of at least one instance of said engineering reference model and a plurality of elements of said unified model data index. | 10-30-2014 |
Patent application number | Description | Published |
20100071088 | Plant Expression Constructs and Methods of Utilizing Same - A Geminivirus based expression construct being capable of systemic symptomeless spread in a plant host is provided as well as methods of utilizing same for plant gene expression, gene silencing and plant protection. | 03-18-2010 |
20110162106 | PLANT EXPRESSION CONSTRUCTS COMPRISING AND USES THEREOF - Methods of expressing a molecule of interest in a plant are disclosed. One method comprises contacting roots of the plant in a solution comprising at least one Geminivirus based expression construct so as to allow the at least one Geminivirus based expression construct to be absorbed by the roots, the expression construct comprising a polynucleotide encoding the molecule of interest, and further the expression construct being capable of systemic symptomless spread in a plant host, thereby expressing a molecule of interest in a plant. Expression constructs capable of systemic symptomless spread in a host plant are also disclosed. | 06-30-2011 |
20120185967 | INTRODUCING DNA INTO PLANT CELLS - The present invention provides means and methods for simple and efficient introduction of foreign genetic material into the plant cell. Particularly, the present invention combines seed priming and virus-based DNA constructs for efficient introduction of heterologous DNA into plants. | 07-19-2012 |
20120258646 | Compositions for Controlling Varroa Mites in Bees - An isolated nucleic acid agent is disclosed comprising a nucleic acid sequence which downregulates expression of a gene product of a | 10-11-2012 |
20140250547 | PLANT EXPRESSION CONSTRUCTS COMPRISING AND USES THEREOF - Methods of expressing a molecule of interest in a plant are disclosed. One method comprises contacting roots of the plant in a solution comprising at least one Geminivirus based expression construct so as to allow the at least one Geminivirus based expression construct to be absorbed by the roots, the expression construct comprising a polynucleotide encoding the molecule of interest, and further the expression construct being capable of systemic symptomless spread in a plant host, thereby expressing a molecule of interest in a plant. Expression constructs capable of systemic symptomless spread in a host plant are also disclosed. | 09-04-2014 |
20140325707 | GROWTH ENHANCEMENT OF PLANTS - The present invention provides means and methods for producing plants with enhanced growth and yield. Particularly, the present invention provides plants to which an expression construct comprising the entire prn operon was introduced, wherein said plants produce pyrrolnitrin and show enhanced growth and yield production compared to corresponding control plants not harboring the prn operon. | 10-30-2014 |
20150133532 | Compositions for Controlling Varroa Mites in Bees - An isolated nucleic acid agent is disclosed comprising a nucleic acid sequence which downregulates expression of a gene product of a | 05-14-2015 |
20150232875 | INTRODUCING DNA INTO PLANT CELLS - The present invention provides means and methods for simple and efficient introduction of foreign genetic material into the plant cell. Particularly, the present invention combines seed priming and virus-based DNA constructs for efficient introduction of heterologous DNA into plants. | 08-20-2015 |
Patent application number | Description | Published |
20120000781 | Electro-blotting Devices, Systems, and Kits and Methods for Their use - The invention provides a dry electroblotting system for dry blotting gels, in which the system includes an electroblotting transfer stack that comprises an analysis gel and a blotting membrane, an anode, a body of anodic gel matrix juxtaposed with the anode between the anode and the transfer stack, a cathode, and a body of cathodic gel matrix juxtaposed with the cathode between the cathode and the transfer stack, in which the anodic gel matrix and the cathodic gel matrix each comprise an ion source for electrophoretic transfer. The dry electroblotting system does not use any liquid buffers that are added to the system just before electroblotting (such as when the transfer stack is being assembled). The anode, the cathode, or both can be separate from a power supply and provided as part of a disposable electrode assembly that also includes a body of gel matrix that includes ions for electrophoretic transfer. | 01-05-2012 |
20120138465 | ELECTRO-BLOTTING DEVICES, SYSTEMS, AND KITS AND METHODS FOR THEIR USE - The invention provides a dry electroblotting system for dry blotting gels, in which the system includes an electroblotting transfer stack that comprises an analysis gel and a blotting membrane, an anode, a body of anodic gel matrix juxtaposed with the anode between the anode and the transfer stack, a cathode, and a body of cathodic gel matrix juxtaposed with the cathode between the cathode and the transfer stack, in which the anodic gel matrix and the cathodic gel matrix each comprise an ion source for electrophoretic transfer. The dry electroblotting system does not use any liquid buffers that are added to the system just before electroblotting (such as when the transfer stack is being assembled). The anode, the cathode, or both can be separate from a power supply and provided as part of a disposable electrode assembly that also includes a body of gel matrix that includes ions for electrophoretic transfer. | 06-07-2012 |
20120211364 | ELECTRO-BLOTTING DEVICES, SYSTEMS, AND KITS AND METHODS FOR THEIR USE - The invention provides an electroblotting system for blotting gels, in which the system includes an electroblotting transfer stack that comprises an analysis gel and a blotting membrane, an anode, an ion source juxtaposed with the anode between the anode and the transfer stack, a cathode, and another ion source juxtaposed with the cathode between the cathode and the transfer stack, in which the each ion source is sufficient for electrophoretic transfer. The anode, the cathode, or both can be separate from a power supply and provided as part of a disposable electrode assembly that also includes a body of gel matrix that includes ions for electrophoretic transfer. | 08-23-2012 |
20140131205 | Electro-Blotting Devices, Systems, and Kits and Methods for Their Use - The invention provides a dry electroblotting system for dry blotting gels, in which the system includes an electroblotting transfer stack that comprises an analysis gel and a blotting membrane, an anode, a body of anodic gel matrix juxtaposed with the anode between the anode and the transfer stack, a cathode, and a body of cathodic gel matrix juxtaposed with the cathode between the cathode and the transfer stack, in which the anodic gel matrix and the cathodic gel matrix each comprise an ion source for electrophoretic transfer. The dry electroblotting system does not use any liquid buffers that are added to the system just before electroblotting (such as when the transfer stack is being assembled). The anode, the cathode, or both can be separate from a power supply and provided as part of a disposable electrode assembly that also includes a body of gel matrix that includes ions for electrophoretic transfer. | 05-15-2014 |
Patent application number | Description | Published |
20100298227 | Treatment of autoimmune conditions with Copolymer 1 and related copolymers - The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal. | 11-25-2010 |
20110171206 | ANTIBODY COMBINATIONS AND USE OF SAME FOR TREATING CANCER - A method of identifying a combination of antibodies with a combined improved anti-tumor activity is provided. The method comprising: (a) identifying binding epitopes of anti ErbB-2 antibodies; and (b) selecting a combination of at least two antibodies of the anti ErbB-2 antibodies exhibiting binding to different epitopes on the ErbB-2, at least one of the different epitopes being localized to a dimerization site of the ErbB-2, the combination of antibodies being with the combined improved anti-tumor activity. Also provided are novel antibody combinations uncovered according to the present teachings. | 07-14-2011 |
20110183437 | METHODS OF IDENTIFYING COMBINATIONS OF ANTIBODIES WITH AN IMPROVED ANTI-TUMOR ACTIVITY AND COMPOSITIONS AND METHODS USING THE ANTIBODIES - A method of identifying a combination of antibodies with a combined improved anti tumor activity is provided. The method comprising identifying at least two anti RTK antibodies capable of inducing synergistic endocytosis of the RTK in a cell expressing the RTK, thereby identifying the combination of antibodies with the combined improved anti-tumor activity. | 07-28-2011 |
20120077754 | COPOLYMER-1 IMPROVEMENTS IN COMPOSITIONS OF COPOLYMERS - The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons. | 03-29-2012 |
20140086917 | COMBINATIONS OF ANTI ErbB ANTIBODIES FOR THE TREATMENT OF CANCER - An article-of-manufacture is provided. The article-of-manufacture comprises a packaging material identified for treating cancer, packaging:
| 03-27-2014 |
20150030560 | TREATMENT OF AUTOIMMUNE CONDITIONS WITH COPOLYMER 1 AND RELATED COPOLYMERS - The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal. | 01-29-2015 |
20150056216 | ANTIBODY COMBINATIONS AND USE OF SAME FOR TREATING CANCER - A method of identifying a combination of antibodies with a combined improved anti-tumor activity is provided. The method comprising: (a) identifying binding epitopes of anti ErbB-2 antibodies; and (b) selecting a combination of at least two antibodies of the anti ErbB-2 antibodies exhibiting binding to different epitopes on the ErbB-2, at least one of the different epitopes being localized to a dimerization site of the ErbB-2, the combination of antibodies being with the combined improved anti-tumor activity. Also provided are novel antibody combinations uncovered according to the present teachings. | 02-26-2015 |
20150266970 | COMBINATIONS OF EPIDERMAL GROWTH FACTOR RECEPTOR TARGETING ANTIBODIES FOR TREATING CANCER - A method of treating triple negative breast cancer in a subject comprising administering to the subject a therapeutically effective amount of a combination of at least two anti epidermal growth factor receptor (EGF-R) antibodies exhibiting binding to different epitopes on the EGF-R, thereby treating triple negative breast cancer. | 09-24-2015 |
20150307883 | APTAMERS, MULTIMERIC APTAMERS AND USES THEREOF - Monomeric and multimeric aptamers are provided. Also provided are pharmaceutical compositions which comprise same and methods of using same. | 10-29-2015 |
Patent application number | Description | Published |
20110106324 | METHODS, DEVICES AND SYSTEMS FOR REMOTE WIND SENSING - A system for monitoring wind characteristics in a volume including a plurality of non-coherent laser anemometers operative to measure wind characteristics in a plurality of corresponding sub-volumes located within the volume and a data processing subsystem operative to receive data from the plurality of non-coherent laser anemometers and to provide output data representing the wind characteristics in the volume. | 05-05-2011 |
20120088955 | ARTERIAL DEVICE, SYSTEM AND METHOD - An arterial device, system and method are provided for use with a patient undergoing a cardiac procedure. The system is configured for enabling one or more arterial devices to be accommodated in the aorta of the patient in use of the system, and a perfusion lumen arrangement provides therethrough a target perfusion flow into the aorta having a target perfusion flow rate that is significantly greater than a nominal perfusion flow rate, by an excess perfusion flow rate. A suction lumen arrangement provides therethrough a suction flow out of the aorta at a suction flow rate. The target perfusion flow rate and the suction flow rate may be concurrently and selectively controlled to cause embolic debris that may be present in the aorta to be diverted to the suction inlet, while providing the nominal flow rate to the body circulation of the patient. | 04-12-2012 |
20130274643 | ARTERIAL DEVICE, SYSTEM AND METHOD FOR REMOVING EMBOLIC DEBRIS - An arterial device, system and method are provided for use with a patient undergoing a cardiac procedure. The system is configured for enabling one or more arterial devices to be accommodated in the aorta of the patient in use of the system, and a perfusion lumen arrangement provides therethrough a target perfusion flow into the aorta having a target perfusion flow rate that is significantly greater than a nominal perfusion flow rate, by an excess perfusion flow rate. A suction lumen arrangement provides therethrough a suction flow out of the aorta at a suction flow rate. The target perfusion flow rate and the suction flow rate may be concurrently and selectively controlled to cause embolic debris that may be present in the aorta to be diverted to the suction inlet, while providing the nominal flow rate to the body circulation of the patient. | 10-17-2013 |
20140309653 | ARTERIAL DEVICE, SYSTEM AND METHOD FOR REMOVING EMBOLIC DEBRIS - An arterial device, system and method are provided for use with a patient undergoing a cardiac procedure. The system is configured for enabling one or more arterial devices to be accommodated in the aorta of the patient in use of the system, and a perfusion lumen arrangement provides therethrough a target perfusion flow into the aorta having a target perfusion flow rate that is significantly greater than a nominal perfusion flow rate, by an excess perfusion flow rate. A suction lumen arrangement provides therethrough a suction flow out of the aorta at a suction flow rate. The target perfusion flow rate and the suction flow rate may be concurrently and selectively controlled to cause embolic debris that may be present in the aorta to be diverted to the suction inlet, while providing the nominal flow rate to the body circulation of the patient. | 10-16-2014 |
20150196310 | ARTERIAL DEVICE, SYSTEM AND METHOD FOR REMOVING EMBOLIC DEBRIS - An arterial device, system and method are provided for use with a patient undergoing a cardiac procedure. The system is configured for enabling one or more arterial devices to be accommodated in the aorta of the patient in use of the system, and a perfusion lumen arrangement provides therethrough a target perfusion flow into the aorta having a target perfusion flow rate that is significantly greater than a nominal perfusion flow rate, by an excess perfusion flow rate. A suction lumen arrangement provides therethrough a suction flow out of the aorta at a suction flow rate. The target perfusion flow rate and the suction flow rate may be concurrently and selectively controlled to cause embolic debris that may be present in the aorta to be diverted to the suction inlet, while providing the nominal flow rate to the body circulation of the patient. | 07-16-2015 |
Patent application number | Description | Published |
20120071011 | ADAPTER FOR HIGH-SPEED ETHERNET - An adapter includes a mechanical frame, which is configured to be inserted into a SFP-type receptacle and contains a socket for receiving a plug of a twisted-pair-type cable. First electrical terminals, held by the mechanical frame, are configured to mate with a connector in the receptacle. Second electrical terminals, held within the socket, are configured to mate with electrical connections of the plug. Circuitry connects the first and second electrical terminals so as to enable interoperation of the plug with the receptacle. | 03-22-2012 |
20130250760 | COMMUNICATION LINK WITH INTRA-PACKET FLOW CONTROL - A method for communication includes transmitting a data packet from a first port to a second port over a communication link. After transmission of a first portion of the data packet, the transmission is temporarily suspended, a flow-control message is sent from the first port to the second port over the communication link while the transmission is temporarily suspended, and then the transmission is resumed so as to transmit a second portion of the data packet. | 09-26-2013 |
20140115206 | METHODS AND SYSTEMS FOR RUNNING NETWORK PROTOCOLS OVER PERIPHERAL COMPONENT INTERCONNECT EXPRESS - Methods and devices for running network protocols over Peripheral Component Interconnect Express are disclosed. The methods and devices may receive an electronic signal comprising data. The methods and devices may also determine the data corresponds to a protocol selected from a set comprising a PCIe protocol and a network protocol. In addition, the methods and devices may also configure a CPU based on the determined protocol. The methods and devices may also receive a second electronic signal comprising second data at a pin or land of the CPU, wherein the pin or land is connected to a PCIe lane and wherein the second data is formatted in accordance with determined protocol. In addition, the methods and devices may process the second data in accordance with the determined protocol. | 04-24-2014 |
20140281840 | METHODS AND SYSTEMS FOR ERROR-CORRECTION DECODING - Methods and systems for efficient Reed-Solomon (RS) decoding are provided. The RS decoding unit includes both an RS pseudo decoder and an RS decoder. The RS pseudo decoder is configured to correct a small number of errors in a received codeword, while the RS decoder is configured to correct errors that are recoverable by the RS code. The RS pseudo decoder runs in parallel with the RS decoder. Once the RS pseudo decoder successfully decodes the codeword, the RS decoder may stop its processing, thereby reducing the RS decoding latency. | 09-18-2014 |
Patent application number | Description | Published |
20090192412 | SENSOR MOUNTED FLEXIBLE GUIDEWIRE - A flexible guidewire comprising a hollow tube, having a proximal section and a distal section, the distal section having a distal tip, the outer diameter of the distal section gradually decreasing toward the distal tip, the outer diameter of the distal tip being larger than the smallest outer diameter of the distal section, the flexible guidewire further comprising a plug coupled with the distal tip of the hollow tube for creating a non-traumatic tip, and the flexible guidewire further comprising a tubular spring, being place around the distal section of the hollow tube for maintaining the outer diameter of the hollow tube over the length thereof and for supporting compressive loads. | 07-30-2009 |
20090192413 | GUIDEWIRE INTERCONNECTING APPARATUS - A male coupler for a guidewire, the guidewire having a hollow walled tube, the male coupler comprising a connector section, coupled with the guidewire, a portion of the connector section having a diameter smaller than the diameter of the hollow tube, at least one conducting ring coupled with the connector section where the diameter of the connector section is smaller the diameter of the guidewire, wherein the diameter of connector section and the at least one conducting ring substantially equals the diameter of the guidewire. | 07-30-2009 |
20110118592 | REDUCING MECHANICAL STRESS ON CONDUCTORS AND CONNECTION POINTS IN A POSITION DETERMINABLE INTERVENTIONAL MEDICAL DEVICE - A medical device configured for diagnosis or treatment of tissues within a body is provided. The device includes an elongate, deformable member configured to be received within a lumen in the body and having proximal and distal ends. A position sensor is disposed at the distal end. In one embodiment, a conductor is wound about the member. The conductor is connected to the position sensor and has a first winding pitch over a first portion of the deformable member and a second winding pitch, different from the first winding pitch, over a second portion of the deformable member. In another embodiment, the member defines a neutral longitudinal axis extending between the proximal and distal ends. A conductor extending between the proximal and distal ends is connected to the position sensor at a connection node on the neutral axis. | 05-19-2011 |
20110152721 | SENSOR MOUNTED FLEXIBLE GUIDEWIRE - A medical device comprising a corewire, sensor core, and coupler is presented. A portion of the corewire is disposed within a first end of the coupler, and a portion of the sensor core is disposed within a second end. Alternatively, the device comprises a corewire and a sensor assembly comprising a sensor core having first and second ends and a bore in the first end. A portion of the corewire is disposed within the bore. A method of manufacture comprises providing a corewire, sensor core, and coupler. The method further comprises inserting a portion of the corewire into a first end of the coupler, and a portion of the sensor core into a second end. Alternatively, the method comprises providing a sensor core having first and second ends, and a corewire. The method further comprises forming a bore in the first end, and inserting the corewire into the bore. | 06-23-2011 |
20120172716 | ELECTROMAGNETIC COIL SENSOR FOR A MEDICAL DEVICE - A positioning sensor for use in a medical device wherein the device has a heat-fused layer comprising a first material having a first melting temperature. The sensor has a tubular core comprising a second material having a second melting temperature that is higher than the first temperature. The core has a central through-bore extending along an axis between opposing axial ends of the core, and where the core further has a radially-outermost outermost winding surface. The sensor includes an electrically conductive coil wound on the winding surface. | 07-05-2012 |
20120172761 | MEDICAL DEVICE GUIDEWIRE WITH A POSITION SENSOR - A guidewire for a medical device is disclosed. In one embodiment, the guidewire includes a corewire having a proximal end portion and a distal end portion, an elongate shroud disposed about the corewire, the shroud having a distal end, and a plug coupled with the distal end portion of the corewire and the distal end of the shroud, the plug having a distal, non-traumatic tip portion, an interior between the corewire and the shroud being configured to receive a sensor. | 07-05-2012 |
20120172842 | METHOD OF ASSEMBLING A POSITIONING SENSOR AND ASSOCIATED WIRING ON A MEDICAL TOOL - An elongate medical device having an axis comprises an inner liner, a jacket radially outward of the liner, a braid comprising metal embedded in the jacket, a sensor, and at least one wire electrically connected to said sensor. The at least one wire is one of: embedded in the jacket and optionally disposed helically around the braid; extending longitudinally within a tube which extends generally parallel to the device axis and wherein the tube is embedded in the jacket; and disposed within a lumen, wherein the lumen extends longitudinally within the jacket. | 07-05-2012 |
20140200556 | Method of assembling a positioning sensor and associated wiring on a medical tool - An elongate medical device having an axis comprises an inner liner, a jacket radially outward of the liner, a braid comprising metal embedded in the jacket, a sensor, and at least one wire electrically connected to said sensor. The at least one wire is one of: embedded in the jacket and optionally disposed helically around the braid; extending longitudinally within a tube which extends generally parallel to the device axis and wherein the tube is embedded in the jacket; and disposed within a lumen, wherein the lumen extends longitudinally within the jacket. | 07-17-2014 |
20140276226 | MEDICAL DEVICE GUIDEWIRE WITH A POSITION SENSOR - A guidewire for a medical device is disclosed. In one embodiment, the guidewire includes a corewire having a proximal end portion and a distal end portion, an elongate shroud disposed about the corewire, the shroud having a distal end, and a plug coupled with the distal end portion of the corewire and the distal end of the shroud, the plug having a distal, non-traumatic tip portion, an interior between the corewire and the shroud being configured to receive a sensor. | 09-18-2014 |
20140378869 | GUIDEWIRE INTERCONNECTING APPARATUS - A male coupler for a guidewire, the guidewire having a hollow walled tube, the male coupler comprising a connector section, coupled with the guidewire, a portion of the connector section having a diameter smaller than the diameter of the hollow tube, at least one conducting ring coupled with the connector section where the diameter of the connector section is smaller the diameter of the guidewire, wherein the diameter of connecter section and the at least one conducting ring substantially equals the diameter of the guidewire. | 12-25-2014 |
20160022958 | REDUCING MECHANICAL STRESS ON CONDUCTORS AND CONNECTION POINTS IN A POSITION DETERMINABLE INTERVENTIONAL MEDICAL DEVICE - A medical device configured for diagnosis or treatment of tissues within a body is provided. The device includes an elongate, deformable member configured to be received within a lumen in the body and having proximal and distal ends. A position sensor is disposed at the distal end. In one embodiment, a conductor is wound about the member. The conductor is connected to the position sensor and has a first winding pitch over a first portion of the deformable member and a second winding pitch, different from the first winding pitch, over a second portion of the deformable member. In another embodiment, the member defines a neutral longitudinal axis extending between the proximal and distal ends. A conductor extending between the proximal and distal ends is connected to the position sensor at a connection node on the neutral axis. | 01-28-2016 |
20160030718 | SENSOR MOUNTED FLEXIBLE GUIDEWIRE - A medical device comprising a corewire, sensor core, and coupler is presented. A portion of the corewire is disposed within a first end of the coupler, and a portion of the sensor core is disposed within a second end. Alternatively, the device comprises a corewire and a sensor assembly comprising a sensor core having first and second ends and a bore in the first end. A portion of the corewire is disposed within the bore. A method of manufacture comprises providing a corewire, sensor core, and coupler. The method further comprises inserting a portion of the corewire into a first end of the coupler, and a portion of the sensor core into a second end. Alternatively, the method comprises providing a sensor core having first and second ends, and a corewire. The method further comprises forming a bore in the first end, and inserting the corewire into the bore. | 02-04-2016 |
20160082228 | GUIDEWIRE INTERCONNECTING APPARATUS - A male coupler for a guidewire, the guidewire having a hollow walled tube, the male coupler comprising a connector section, coupled with the guidewire, a portion of the connector section having a diameter smaller than the diameter of the hollow tube, at least one conducting ring coupled with the connector section where the diameter of the connector section is smaller the diameter of the guidewire, wherein the diameter of connector section and the at least one conducting ring substantially equals the diameter of the guidewire. | 03-24-2016 |
Patent application number | Description | Published |
20090035369 | Composition and Methods for Treating and Preventing Age-Related Macular Degeneration - The present invention relates to methods and compositions effective in preventing, attenuating, inhibiting the progression of, and treating eye diseases, e.g., age-related macular degeneration (AMD). The compositions comprise, as an active ingredient, an effective amount of 3,3′-diindolylmethane (DIM) and/or its precursor indole-3-carbinol (I3C). The compositions can further comprise additional agents such as carotenoids and other phytochemicals, which produce a synergistic effect in preventing, attenuating, inhibiting the progression of, and treating AMD and other eye diseases such as glaucoma, cataracts and diabetic retinopathy (DR). The compositions are particularly effective in treating and preventing wet AMD, and in preventing or inhibiting the progression of dry AMD (non-neovascular) to wet AMD (neovascular). | 02-05-2009 |
20090069417 | CAROTENOID OXIDATION PRODUCTS AS CHEMOPREVENTIVE AND CHEMOTHERAPEUTIC AGENTS - The present invention relates to a method for the chemoprevention and treatment of cancer, by administering a pharmaceutical composition comprising a carotenoid derivative, such as a derivative of lycopene, a- and b-carotene, phytoene, phytofluene, lutein, zeaxanthin, α- and β-cryptoxanthin, canthaxanthin, astaxanthin, or other carotenoid. The carotenoid derivative is a carotenoid oxidation product, and is preferably an aldehyde derivative, a dialdehyde derivative or a ketone derivative. The carotenoid derivative can be a derivative of any naturally occurring carotenoid, such as those found in tomatoes and other fruits and vegetables. | 03-12-2009 |
20100291200 | FORMULATIONS FOR POORLY SOLUBLE DRUGS - The present invention provides a drug delivery system comprising nanoparticles or microparticles of a water poorly soluble drug dispersed in a polymeric bead containing essentially only of hydrophilic polymers (i.e. without hydrophobic polymers). The present invention further provides a method of producing the drug delivery system of the invention. | 11-18-2010 |
20100330178 | EXTENDED RELEASE COMPOSITIONS COMPRISING AS ACTIVE COMPOUND VENLAFAXINE HYDROCHLORIDE - The present invention relates to an extended release composition comprising as active compound Venlafaxine Hydrochloride, in which Venlafaxine Hydrochloride is coated on a non pareil inert core, which coated core is then coated with polymeric layer which enables the controlled release of the Venlafaxine Hydrochloride. | 12-30-2010 |
20110230513 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PARKINSONS DISEASE - Pharmaceutical compositions are provided for treatment of Parkinson's disease comprising a pharmaceutically acceptable carrier and a fixed dose combination of two active agents selected from compounds having either neuroprotective or symptomatic effects, or both, in Parkinson's disease patients, wherein the molar ratio of the two compounds is in the range of 1:1 to 1:100. The compositions are formulated for immediate release, controlled release, or both immediate and controlled release | 09-22-2011 |
20120135082 | EXTENDED RELEASE COMPOSITIONS COMPRISING AS ACTIVE COMPOUND VENLAFAXINE HYDROCHLORIDE - The present invention relates to an extended release composition comprising as active compound Venlafaxine Hydrochloride, in which Venlafaxine Hydrochloride is coated on a non pareil inert core, which coated core is then coated with polymeric layer which enables the controlled release of the Venlafaxine Hydrochloride. | 05-31-2012 |
20120301542 | EXTENDED RELEASE FORMULATIONS OF RASAGILINE AND USES THEREOF - The present invention provides various pharmaceutical compositions, in particular for oral administration, formulated for extended release of active compounds useful in the treatment of neurodegenerative diseases, in particular Parkinson's disease, and injuries to the nervous system. The active compound comprised within these compositions is preferably selected from N-propargyl-1-aminoindan, an enantiomer thereof, or a pharmaceutically acceptable salt thereof, more preferably rasagiline or a pharmaceutically acceptable salt thereof. | 11-29-2012 |
20130115298 | EXTENDED RELEASE COMPOSITIONS COMPRISING AS ACTIVE COMPOUND VENLAFAXINE HYDROCHLORIDE - The present invention relates to an extended release composition comprising as active compound Venlafaxine Hydrochloride, in which Venlafaxine Hydrochloride is coated on a non pareil inert core, which coated core is then coated with polymeric layer which enables the controlled release of the Venlafaxine Hydrochloride. | 05-09-2013 |
20150133513 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PARKINSONS DISEASE - Pharmaceutical compositions are provided for treatment of Parkinson's disease comprising a pharmaceutically acceptable carrier and a fixed dose combination of two active agents selected from compounds having either neuroprotective or symptomatic effects, or both, in Parkinson's disease patients, wherein the molar ratio of the two compounds is in the range of 1:1 to 1:100. The compositions are formulated for immediate release, controlled release, or both immediate and controlled release. | 05-14-2015 |