Patent application number | Description | Published |
20140135712 | Visual Indication of Rupture of Drug Reservoir - Devices and methods are provided for visualizing the opening of a drug reservoir of an implantable medical device. The disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker, and a plurality of barrier layers for separating the contents of the reservoirs from the anatomy. The method further includes irradiating at least one of the barrier layers such that at least one of the reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified. | 05-15-2014 |
20140148792 | Laser-Activated Drug Delivery Device - Devices and methods are provided for selectively delivering a drug by laser activation. The device includes structural elements forming a hermetic, enclosed reservoir, and at least one drug unit contained in the enclosed reservoir. The at least one drug unit includes a drug. The device is able to absorb laser irradiation effective to open the enclosed reservoir to permit release of the drug. The method includes implanting a drug delivery device into a tissue site of a patient, and irradiating at least a portion of the drug delivery device to breach the enclosed reservoir to permit the drug to be released in tissues at the tissue site. | 05-29-2014 |
20140336593 | DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF - Drug delivery devices are provided that are configured to release drug following passive or active activation of the device protecting the drug contained therein. In one aspect, the device may be configured to release a drug following selective application of light irradiation to the device. In another aspect, the device is configured to a release drug following degradation of at least a part of the device body that is formed, for example, from a bioerodible, hermetic material. An exemplary bioerodible, hermetic material is a biodegradable glass. Still other aspects provide for release of a drug upon a combination of both passive and active activation of the device. | 11-13-2014 |