Sampas
George P. Sampas, Santa Barbara, CA US
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20130081119 | MOBILE DEVICE-BASED AUTHENTICATION - Mobile device-based authentication is disclosed. A first biometric input corresponding to a first biometric feature of the user is captured on the mobile device. A first set of biometric data is derived from the captured first biometric input. The first set of biometric data is transmitted to a remote authentication server. Thereafter, a secondary authentication instruction is transmitted to the site resource in response. Access to the site resource is permitted based upon a validation of the first set of biometric data, and a second biometric input that is captured on the site resource in response to the secondary authentication instruction received thereon. The first set of biometric data and the second set of biometric data are validated by remote authentication server substantially contemporaneously. | 03-28-2013 |
20130254862 | MOBILE DEVICE-BASED AUTHENTICATION - Mobile device-based authentication is disclosed. A first biometric input corresponding to a first biometric feature of the user is captured on the mobile device. A first set of biometric data is derived from the captured first biometric input. The first set of biometric data is transmitted to a remote authentication server. Thereafter, a secondary authentication instruction is transmitted to the site resource in response. Access to the site resource is permitted based upon a validation of the first set of biometric data, and a second biometric input that is captured on the site resource in response to the secondary authentication instruction received thereon. The first set of biometric data and the second set of biometric data are validated by remote authentication server substantially contemporaneously. | 09-26-2013 |
20140201537 | MOBILE DEVICE-BASED AUTHENTICATION WITH ENHANCED SECURITY MEASURES PROVIDING FEEDBACK ON A REAL TIME BASIS - The tracking of user authentication is disclosed. A first user biometric data set is received from a mobile device on an authentication server, and a second user biometric data set is received from a site resource on the authentication server. The second user biometric is transmitted from the site resource in response to receipt of an authentication command from the mobile device on the site resource. The user is rejected for access to the site resource in the event of an authentication failure. A security procedure is initiated on at least one of the mobile device and a remote physical device separate from the mobile device in response to the rejecting of the user for access to the site resource. | 07-17-2014 |
Nicholas M. Sampas, San Francisco, CA US
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20100279883 | Probe Design Methods and Microarrays for Comparative Genomic Hybridization and Location Analysis - Methods and systems for identifying and selecting nucleic acid probes for detecting a target with a nucleic acid probe array or comparative genome hybridization microarray, comprising selecting a plurality of potential target sequences, generating a plurality of candidate probes from the target sequences, filtering the plurality of candidate probes by analyzing candidate probes for selected probe properties in silico. Microarrays comprising probes selected by the methods of the invention are particularly useful for comparative genome hybridization and location analysis. | 11-04-2010 |
Nicholas M. Sampas, San Jose, CA US
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20090035764 | Methods and systems for evaluating CGH candidate probe nucleic acid sequences - Methods of evaluating candidate CGH probe nucleic acid sequences are provided. Aspects of the methods include providing a candidate CGH probe nucleic acid sequence for a target sequence of a copy number variation (CNV) of a genome. A proximity score is then determined for the candidate CGH probe nucleic acid sequence and employed to evaluate the sequence. Aspects of the invention further include computer programming and systems that include the same which are configured to evaluate candidate CGH probe nucleic acid sequences using a proximity score. | 02-05-2009 |
20090036319 | Methods and systems for pairwise filtering candidate probe nucleic acid sequences - Aspects of the invention include methods of systems of pairwise filtering candidate probe nucleic acid sequences. Aspects of the invention further include methods and systems of selecting candidate probe nucleic acid sequences from plurality thereof, which methods and systems employ a pairwise elimination ranked record of a plurality of candidate probe nucleic acids for a genomic region of interest. | 02-05-2009 |
20090062138 | Array-based method for performing SNP analysis - An array-based method for performing SNP analysis is provided. In certain embodiments, the method may comprise: a) contacting a labeled genomic sample with an array comprising a first SNP-detecting oligonucleotide and a second SNP-detecting oligonucleotide that differ from each other by a single nucleotide, under hybridization conditions that provide binding equilibrium; and b) evaluating a SNP of said labeled genomic sample by comparing: i. binding of the labeled genomic sample to the first SNP-detecting oligonucleotide and ii. binding of the labeled genomic sample to said second SNP-detecting oligonucleotide. | 03-05-2009 |
20100076969 | METHODS AND SYSTEMS FOR CLUSTERING BIOLOGICAL ASSAY DATA - Methods for clustering a data set from a biological assay are provided. Aspects of the methods include applying statistical analyses to bisected subsets of the data at selected cut-of values to identify one or more break points in the data set. In certain aspects, the statistical analyses employed are based on determining the p-values of two-tailed t-tests calculated using the bisected data at each cut-off value. Aspects of the invention further include computer programming and systems which are configured to cluster data sets from biological assays according to the subject methods. | 03-25-2010 |
20110039716 | Analysis of Single Nucleotide Polymorphisms Using a Nicking Endonuclease - A method of genome analysis is provided. In certain embodiments, the method comprises: a) contacting a double-stranded genomic DNA with a site-specific nicking endonuclease that recognizes a sequence comprising a single nucleotide polymorphism (SNP), in which the endonuclease nicks the genomic DNA at a nick site only if a first allele of the SNP is present; b) denaturing the genomic sample; c) contacting the denatured genomic sample with an array comprising a first probe and a second probe, in which nicking results in less binding of the denatured sample to the first probe relative to a sample that is not nicked; and d) comparing the amount of hybridization to the first probe to the amount of hybridization to said second probe, in which decreased binding of the denatured genomic samples to the first probe relative to the second probe indicates that the first allele of the SNP is present. | 02-17-2011 |
20110250595 | ANALYSIS OF SINGLE NUCLEOTIDE POLYMORPHISMS USING END LABELING - A method for analyzing a sequence comprising a SNP site is provide. In general terms, the method comprises: a) contacting a first DNA sample with a first restriction enzyme to provide DNA fragments, wherein: i) the first restriction enzyme cleaves the sequence only if a first allele of a SNP is present at the SNP site; b) end-labeling the DNA fragments to produce an end-labeled sample; c) hybridizing the end-labeled sample to an array comprising a probe sequence; and d) comparing the amount of hybridization between the digested sample and the probe sequence to a reference signal | 10-13-2011 |
20110301854 | Method of Determining Allele-Specific Copy Number of a SNP - A method of estimating the allele-specific copy number of a SNP in a test genome is provided. In certain embodiments, the method involves: a) calculating a plurality of probability distribution functions that fit a plurality of log ratios indicating which alleles of a plurality of single nucleotide polymorphisms (SNPs) are present in diploid regions of a test and reference genome; and b) estimating the allele-specific copy number of a SNP of the test genome using said plurality of probability distribution functions. | 12-08-2011 |
Nicholas M. Sampas, Loveland, CO US
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20120283108 | METHOD FOR PHASED GENOTYPING OF A DIPLOID GENOME - A method of sample analysis is provided. In certain embodiments the method comprises: a) obtaining from a diploid individual a chromosomal sample that comprises maternally-derived chromosomes and homologous paternally-derived chromosomes; b) determining the parent of origin of a first chromosome of the sample by detecting a parent-specific copy number variation relative to a second chromosome that is homologous to the first chromosome; c) isolating the first chromosome; and d) genotyping the first chromosome. | 11-08-2012 |
20140255924 | TWIST-TIE OLIGONUCLEOTIDE PROBES - A composition comprising population of labeled oligonucleotides is provided herein. In some embodiments, the probes are of the formula: T | 09-11-2014 |
Nicholas M. Sampas, San Carlos, CA US
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20120004123 | SNP-DEPENDENT END LABELING METHOD - Certain embodiments described in this disclosure relate to a method of sample analysis. In certain cases, the method comprises: a) contacting a genomic sample comprising double-stranded genomic DNA with a first restriction endonuclease that recognizes a nucleotide sequence that comprises a SNP site in the double stranded genomic DNA, wherein: i. the restriction endonuclease cleaves the genomic DNA at the sequence regardless of the allele of the SNP present at the SNP site; and ii. cleavage of the sequence by the restriction enzyme creates a 5′ overhang that comprises the SNP site; b) contacting the digested genomic sample with a extension enzyme and a first labeled nucleotide that is used by the extension enzyme to fill in the overhang only if the overhang comprises a first allele of the SNP. | 01-05-2012 |
Nicholas M. Sampas, Santa Clara, CA US
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20140212869 | Nucleic Acid Proximity Assay Involving the Formation of a Three-way junction - Provided herein is a proximity assay that, in certain embodiments, involves: (a) hybridizing a first oligonucleotide and a second oligonucleotide with a target nucleic acid, wherein the first oligonucleotide comprises: i. a region that is complementary to a first sequence in the target nucleic acid and ii. a barcode sequence; and the second oligonucleotide comprises i. a region that is complementary to a second region in the target and ii. the complement of the barcode sequence; and (b) detecting hybridization between the barcode sequence and the complement of the barcode sequence, wherein hybridization between the barcode sequence and the complement of the barcode sequence indicates that the first and second target sequences are proximal to one another in the sample. | 07-31-2014 |
Nicholas Michael Sampas, San Jose, CA US
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20090035762 | Allele-specific copy number measurement using single nucleotide polymorphism and DNA arrays - Methods and systems for allelic detection and allele-specific copy number are provided herein. The described methods use identification of single nucleotide polymorphism using restriction enzymes and CGH analyses. Microarrays comprising probes designed by the described methods are provided. Also included are methods for identifying SNP sites and copy number in samples obtained from patient populations. | 02-05-2009 |