Patent application number | Description | Published |
20110034209 | WIRELESS TECHNOLOGY AS A DATA CONDUIT IN THREE-DIMENSIONAL ULTRASONOGRAY - An imaging system, having: an imaging data acquisition device; a remote image reconstruction and data processing facility; and a wireless data transfer to transmit raw data from the data acquisition device to the remote facility. At the facility, the raw data is processed to prepare a diagnostic image that can be transmitted to an expert or non-expert, or transmitted back to the display of the wireless data transfer device. | 02-10-2011 |
20110118732 | CONTROLLED IRREVERSIBLE ELECTROPORATION - Electrical pulses are applied to tissue in a manner which destroys targeted cells such as cancerous cells while sparing non-targeted cells such as nerve cells. The electrical pulses are controlled within ranges for voltage, wattage and duration of application. Multiple pulses or groups of pulses may be applied to obtain a desired result while maintaining any temperature increase below a level which destroys cells. | 05-19-2011 |
20110193575 | VOLUMETRIC INDUCTION PHASE SHIFT DETECTION SYSTEM FOR DETERMINING TISSUE WATER CONTENT PROPERTIES - A method of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample. An apparatus for determining the condition of a bulk tissue sample, having: a first induction coil (or antenna); a second induction coil (or antenna); an alternating current power supply connected to the first induction coil (or antenna), the alternating current power supply configured to generate a spectrum of currents (or voltage) in the first induction coil (or antenna); and a measurement system connected to the second induction coil (or antenna), wherein the measurement system is configured to measure a phase shift difference in the spectrum of currents (or voltages) between the first and second induction coils (or antennae) when the first and second induction coils (or antennae) are positioned on opposite sides of a tissue sample. | 08-11-2011 |
20120034131 | APPARATUS, SYSTEM AND METHOD FOR PREVENTING BIOLOGICAL CONTAMINATION TO MATERIALS DURING STORAGE USING PULSED ELECTRICAL ENERGY - A container having a main storage space for holding a matter, having an inlet/outlet opening and fitted with a PEF system. The PEF system comprises two or more electrodes disposed within said container and contacting the matter; and electric pulse source connected to the two or more electrodes and adapted to pass pulsed electric energy through the matter. The PEF system being activated to deliver a treatment protocol to the matter. | 02-09-2012 |
20120071874 | TISSUE ABLATION WITH IRREVERSIBLE ELECTROPORATION - A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable. | 03-22-2012 |
20120146621 | VOLUMETRIC INDUCTION PHASE SHIFT DETECTION SYSTEM FOR DETERMINING TISSUE WATER CONTENT PROPERTIES - A method and apparatus of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample. | 06-14-2012 |
20120179091 | GELS WITH PREDETERMINED CONDUCTIVITY USED IN ELECTROPORATION OF TISSUE - Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues. | 07-12-2012 |
20120226218 | EXTRACELLULAR MATRIX MATERIAL CREATED USING NON-THERMAL IRREVERSIBLE ELECTROPORATION - Extracellular matrix material is disclosed which is created by subjecting a target area to non-thermal irreversible electroporation (NTIRE) with a pulsed electrical field to kill cells in the absence of thermal damage. The dead cellular material may be removed and the remaining non-cellular matrix material may be implanted into a repair site to be treated medically or cosmetically. | 09-06-2012 |
20120277741 | TISSUE ABLATION WITH IRREVERSIBLE ELECTROPORATION - A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable. | 11-01-2012 |
20130187666 | VOLUMETRIC INDUCTION PHASE SHIFT DETECTION SYSTEM FOR DETERMINING TISSUE WATER CONTENT PROPERTIES - A method and apparatus of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample. | 07-25-2013 |
20130196441 | ELECTROPORATION ELECTRODE CONFIGURATION AND METHODS - Provided herein are the concept that “singularity-based configuration” electrodes design and method can produce in an ionic substance local high electric fields with low potential differences between electrodes. The singularity-based configuration described here includes: an anode electrode; a cathode electrode; and an insulator disposed between the anode electrode and the cathode electrode. The singularity-based electrode design concept refers to electrodes in which the anode and cathode are adjacent to each other, placed essentially co-planar and are separated by an insulator. The essentially co-planar anode/insulator/cathode configuration bound one surface of the volume of interest and produce desired electric fields locally, i.e., in the vicinity of the interface between the anode and cathode. In an ideal configuration, the interface dimension between the anode and the cathode tends to zero and becomes a point of singularity. | 08-01-2013 |
20130197425 | CURRENT CAGE FOR REDUCTION OF A NON-TARGET TISSUE EXPOSURE TO ELECTRIC FIELDS IN ELECTROPORATION BASED TREATMENT - The invention shows the relation between the volumes of tissue that experiences muscle contraction inducing electric fields, V | 08-01-2013 |
20130202766 | Composition, Methods and Devices for Reduction of Cells in a Volume of Matter Using Low Voltage High Electric Field (LVHEF) Electrical Energy - The present disclosure provides devices, systems, and methods for affecting cells using low voltage high electric fields (LVHEF). In one embodiment, the present disclosure provides for reduction of microbial contamination using low voltage high electric fields. The devices of the disclosure are generally capable of affecting cells in a portion of a volume of matter of interest using one or more arrangements of electrodes configured to generate high electric fields powered by low voltages (LVHEF). In one embodiment, the present disclosure provides for exposure of cells to a low voltage high electric field such that at least a portion of the cells in a portion of the volume of interest are killed. While only a portion of the matter is treated at a single time, the treatments are repeated. Over time, the portion of matter in the treated volume is mixed with untreated matter and re-treated with LVHEF until the entire volume of matter of interest is treated to the desired level. The voltage required to treat the volume of matter of interest with LVHEF is substantially lower than the voltage required for treating the volume of matter of interest through a single application of the high electric fields without mixing. In one aspect, electrodes are arranged in a co-planar configuration. The disclosure provides for a variety of applications and products, including consumer goods and pharmaceuticals. | 08-08-2013 |
20130345779 | TWO DIMENSIONAL AND ONE DIMENSIONAL FIELD ELECTROPORATION - The shape and relative positions of two or more electrodes connected to a shaped metal surface are adjusted. By adjusting the shape and position of the electrodes, as well as the shape of the metal surface, the shape of the electrical field generated from the metal surface is precisely defined. The metal surface is brought into contact with cells and the defined electrical field provides reversible or irreversible electroporation to cells in a precisely defined area. The metal surface may be comprised of copper, silver, gold or other conductive material and combinations thereof and the voltage, wattage and duration of electricity applied to the electrodes can be varied to obtain a desired result. | 12-26-2013 |
20140088578 | CRYOELECTRIC SYSTEMS AND METHODS FOR TREATMENT OF BIOLOGICAL MATTER - Systems and methods are disclosed for treating a target volume of biological matter, by cooling a volume of tissue to a temperature below freezing, and directing an electric field through the cooled volume of tissue or tissue adjacent to the cooled volume of tissue to generate at least a temporary physiological affect on one or more of the cooled volume of tissue and adjacent volume of tissue. The generated physiological affect may include shielding a region of tissue from treatment, focusing treatment on a particular region of tissue, and sterilization of tissue. | 03-27-2014 |
20140163551 | IRREVERSIBLE ELECTROPORATION DEVICE AND METHOD FOR ATTENUATING NEOINTIMAL FORMATION - Restenosis or neointimal formation may occur following angioplasty or other trauma to an artery such as by-pass surgery. This presents a major clinical problem which narrows the artery. The invention provides a device and a method whereby vascular cells in the area of the artery subjected to the trauma are subjected to irreversible electroporation which is a non-thermal, non-pharmaceutical method of applying electrical pulses to the cells so that substantially all of the cells in the area are ablated while leaving the structure of the vessel in place and substantially unharmed due to the non-thermal nature of the procedure. | 06-12-2014 |
20140176158 | Volumetric Induction Phase Shift Detection System for Determining Tissue Water Content Properties - A method and apparatus of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample. | 06-26-2014 |
20140309579 | BALLOON CATHETER METHOD FOR REDUCING RESTENOSIS VIA IRREVERSIBLE ELECTROPORATION - Restenosis or neointimal formation may occur following angioplasty or other trauma to an artery such as by-pass surgery. This presents a major clinical problem which narrows the artery. The invention provides a balloon catheter with a particular electrode configuration. Also provided is a method whereby vascular cells in the area of the artery subjected to the trauma are subjected to irreversible electroporation which is a non-thermal, non-pharmaceutical method of applying electrical pulses to the cells so that substantially all of the cells in the area are ablated while leaving the structure of the vessel in place and substantially unharmed due to the non-thermal nature of the procedure. | 10-16-2014 |
Patent application number | Description | Published |
20080224688 | Volumetric Induction Phase Shift Detection System for Determining Tissue Water Content Properties - A method of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample. An apparatus for determining the condition of a bulk tissue sample, having: a first induction coil (or antenna); a second induction coil (or antenna); an alternating current power supply connected to the first induction coil (or antenna), the alternating current power supply configured to generate a spectrum of currents (or voltage) in the first induction coil (or antenna); and a measurement system connected to the second induction coil (or antenna), wherein the measurement system is configured to measure a phase shift difference in the spectrum of currents (or voltages) between the first and second induction coils (or antennae) when the first and second induction coils (or antennae) are positioned on opposite sides of a tissue sample. | 09-18-2008 |
20090292342 | Methods and Systems for Treating BPH Using Electroporation - A system for treating benign prostate hyperplasia (BPH) of a prostate. At least first and second mono-polar electrodes are configured to be introduced at or near a BPH tissue site of the prostate gland of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the BPH tissue site, to create necrosis of cells of the BPH tissue site, but insufficient to create a thermal damaging effect to a majority of the BPH tissue site. | 11-26-2009 |
20100097081 | Volumetric Induction Phase Shift Detection System for Determining Tissue Water Content Properties - A method of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample. An apparatus for determining the condition of a bulk tissue sample, having: a first induction coil (or antenna); a second induction coil (or antenna); an alternating current power supply connected to the first induction coil (or antenna), the alternating current power supply configured to generate a spectrum of currents (or voltage) in the first induction coil (or antenna); and a measurement system connected to the second induction coil (or antenna), wherein the measurement system is configured to measure a phase shift difference in the spectrum of currents (or voltages) between the first and second induction coils (or antennae) when the first and second induction coils (or antennae) are positioned on opposite sides of a tissue sample. | 04-22-2010 |
20120071872 | Systems for Treating Tissue Sites Using Electroporation - A system for treating a tissue site. At least first and second mono-polar electrodes are configured to be introduced at or near a tissue site of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the tissue site, to create necrosis of cells of the tissue site, but insufficient to create a thermal damaging effect to a majority of the tissue site. | 03-22-2012 |
Patent application number | Description | Published |
20130202766 | Composition, Methods and Devices for Reduction of Cells in a Volume of Matter Using Low Voltage High Electric Field (LVHEF) Electrical Energy - The present disclosure provides devices, systems, and methods for affecting cells using low voltage high electric fields (LVHEF). In one embodiment, the present disclosure provides for reduction of microbial contamination using low voltage high electric fields. The devices of the disclosure are generally capable of affecting cells in a portion of a volume of matter of interest using one or more arrangements of electrodes configured to generate high electric fields powered by low voltages (LVHEF). In one embodiment, the present disclosure provides for exposure of cells to a low voltage high electric field such that at least a portion of the cells in a portion of the volume of interest are killed. While only a portion of the matter is treated at a single time, the treatments are repeated. Over time, the portion of matter in the treated volume is mixed with untreated matter and re-treated with LVHEF until the entire volume of matter of interest is treated to the desired level. The voltage required to treat the volume of matter of interest with LVHEF is substantially lower than the voltage required for treating the volume of matter of interest through a single application of the high electric fields without mixing. In one aspect, electrodes are arranged in a co-planar configuration. The disclosure provides for a variety of applications and products, including consumer goods and pharmaceuticals. | 08-08-2013 |
20130345779 | TWO DIMENSIONAL AND ONE DIMENSIONAL FIELD ELECTROPORATION - The shape and relative positions of two or more electrodes connected to a shaped metal surface are adjusted. By adjusting the shape and position of the electrodes, as well as the shape of the metal surface, the shape of the electrical field generated from the metal surface is precisely defined. The metal surface is brought into contact with cells and the defined electrical field provides reversible or irreversible electroporation to cells in a precisely defined area. The metal surface may be comprised of copper, silver, gold or other conductive material and combinations thereof and the voltage, wattage and duration of electricity applied to the electrodes can be varied to obtain a desired result. | 12-26-2013 |
20140088578 | CRYOELECTRIC SYSTEMS AND METHODS FOR TREATMENT OF BIOLOGICAL MATTER - Systems and methods are disclosed for treating a target volume of biological matter, by cooling a volume of tissue to a temperature below freezing, and directing an electric field through the cooled volume of tissue or tissue adjacent to the cooled volume of tissue to generate at least a temporary physiological affect on one or more of the cooled volume of tissue and adjacent volume of tissue. The generated physiological affect may include shielding a region of tissue from treatment, focusing treatment on a particular region of tissue, and sterilization of tissue. | 03-27-2014 |