Patent application number | Description | Published |
20080215002 | METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING - A method for cerebral and systemic cooling by circulating a cold liquid through a nasal catheter looped through the patient's nasal cavities and around the nasal septum. The nasal catheter is inserted into the patient's first nostril, advanced through the nasal cavity, around the nasal septum and out of the patient's second nostril. A cold fluid having a temperature between about −20° C. and about 37° C. is flowed though a lumen in the nasal catheter to cool the nasal cavity. The nasal catheter may have one or more flexible balloons mounted on the catheter such that when the catheter is looped around the nasal septum, the balloon(s) are positioned in a portion of the patient's first and second nasal cavities. When a cold liquid is circulated through the catheter lumen, the flexible balloons expand to a contact the inner walls of the nasal cavities and provide direct cooling of the nasal cavities. | 09-04-2008 |
20080249188 | METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING - A method for cerebral and systemic cooling by providing a nebulized liquid having a boiling point of 38-300° C. The nebulized liquid is delivered as a mist or a spray via the nasal and/or oral cavities of a patient. The mist causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. Compositions and medical devices for cerebral and systemic cooling are also provided. Cooling assemblies, and methods of use, are also provided that include flexible balloon assemblies that are inserted to various locations in a patient's body. The flexible balloons are then infused with a liquid having a temperature between about −20° C. and about 37° C. The flexible balloon assemblies can be inserted into the nasal cavity, oral cavity, throat, stomach, and other locations to effect cerebral cooling. | 10-09-2008 |
20090165786 | TRANSPULMONARY SYSTEMIC COOLING USING LIQUID MISTS - A method for transpulmonary cooling by providing a liquid having a boiling point of 38-300° C., more preferably 38-250° C., more preferably 38-200° C., more preferably 38-150° C., more preferably 38-80° C. The liquid is nebulized to form a mist. The mist is optionally cooled below room temperature and delivered to the airway of a patient so that the patient inhales the mist. The mist causes systemic cooling by evaporative heat loss when inhaled at room temperature and additionally by direct heat transfer when inhaled below room temperature. Compositions and medical devices for transpulmonary cooling are also provided. | 07-02-2009 |
20110028938 | METHODS AND DEVICES FOR TREATMENT OF MIGRAINES - Methods for treating a migraine by cooling a patient's nasopharyngeal cavity are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. The cooling assembly includes a flexible balloon defining a chamber and a first elongate tubular member having a lumen in fluid communication with the chamber. A liquid having a temperature between about −20° C. and about 37° C. is infused through the lumen of the first elongate tubular member into the chamber, wherein the flexible balloon expands to place it in contact with the nasal cavity. In another method, an elongate member having a plurality of ports is inserted into the nasal cavity. A perfluorocarbon spray and a gas are then delivered onto a surface of the nasal cavity through the plurality of ports. | 02-03-2011 |
20120083764 | METHODS AND DEVICES FOR TREATMENT OF MIGRAINES - Methods for treating a migraine by cooling a patient's nasopharyngeal cavity are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. The cooling assembly includes a flexible balloon defining a chamber and a first elongate tubular member having a lumen in fluid communication with the chamber. A liquid having a temperature between about −20° C. and about 37° C. is infused through the lumen of the first elongate tubular member into the chamber, wherein the flexible balloon expands to place it in contact with the nasal cavity. In another method, an elongate member having a plurality of ports is inserted into the nasal cavity. A perfluorocarbon spray and a gas are then delivered onto a surface of the nasal cavity through the plurality of ports. | 04-05-2012 |
Patent application number | Description | Published |
20100211140 | METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING - A method for providing and adjusting cerebral cooling in response to changes in a physiological parameter. A spray having a boiling point between 38-300° C. is delivered to the surface of a patient's nasal cavities. The spray causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. A physiological parameter, such as cerebral temperature, changes in cerebral blood flow or brain oxygenation is monitored. The delivery rate of the spray is adjusted in response to the physiological parameter. | 08-19-2010 |
20100324483 | DEVICES FOR COOLING THE NASAL CAVITY - A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure from the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon. | 12-23-2010 |
20120197362 | DEVICES FOR COOLING THE NASAL CAVITY - A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure front the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon. | 08-02-2012 |
20130073015 | METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING ALTERNATING LIQUID MIST/GAS FOR INDUCTION AND GAS FOR MAINTENANCE - Methods for cerebral and systemic cooling via a patient's nasopharyngeal cavity are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. A substantially dry gas is delivered through a lumen of the catheter onto the surface of the patient's nasal cavity. Evaporative heat loss cools the patient's nasal cavity. If additional cooling is needed, a liquid coolant is delivered through a separated lumen of the catheter. The liquid coolant is nebulized at a plurality of delivery ports on the distal end of the catheter and is delivered onto the surface of the patient's nasal cavity in combination with the dry gas. The dry gas enhances evaporation of the nebulized coolant and additional cooling is provided from the evaporative heat loss of the liquid coolant. | 03-21-2013 |
20130269692 | SYSTEM AND METHOD FOR IMPROVING OUTCOME OF CEREBRAL ISCHEMIA - A system for improving outcome following cerebral ischemia is provided. The system includes a source of nitric oxide and an elongate tubular member for insertion into a nose including at least one orifice thereon. The tubular member is coupled to the source of nitric oxide and the elongate tubular member configured for delivering the nitric oxide into a nasal cavity through the at least one orifice for absorption into a cerebral vasculature through a nasal vasculature. A means for controlling flow of the gas, a concentration of the nitric oxide in the gas, or both, is also provided. | 10-17-2013 |
20130273179 | SYSTEM AND METHOD FOR IMPROVING OUTCOME OF CEREBRAL ISCHEMIA - A method for improving outcome following cerebral ischemia is provided. The method includes delivering nitric oxide into the nasal cavity for absorption into the brain through the nasal vasculature and preventing the inhalation of nitric oxide into the lungs to prevent pulmonary vasodilatation. | 10-17-2013 |
20130273180 | SYSTEM AND METHOD FOR IMPROVING OUTCOME OF CEREBRAL ISCHEMIA - A method for improving outcome following cerebral ischemia is provided. The method includes delivering nitric oxide into the nasal cavity for absorption into the brain through the nasal vasculature and maintaining the nitric oxide in the nasal cavity. | 10-17-2013 |
20130274651 | SYSTEM AND METHOD FOR IMPROVING OUTCOME OF CEREBRAL ISCHEMIA - A system for improving outcome following cerebral ischemia is provided. The system includes a source of nitric oxide and an elongate tubular member for insertion into a nose including at least one orifice thereon. The tubular member is coupled to the source of nitric oxide and the elongate tubular member configured for delivering the nitric oxide into a nasal cavity through the at least one orifice for absorption into a cerebral vasculature through a nasal vasculature. A means for controlling flow of the gas, a concentration of the nitric oxide in the gas, or both, is also provided. | 10-17-2013 |
20130296443 | SYSTEM AND METHOD OF TRANS-VENOUS PRE-AORTIC GANGLION ABLATION - A method of modulating a physiological parameter of a patient is provided. The method includes disabling one or more pre-aortic ganglion cells within a pre-aortic ganglion trans-venously and improving the physiological parameter. The method further includes destroying a pre-aortic ganglion cell trans-venously to prevent regeneration. | 11-07-2013 |
20130296646 | NON-INVASIVE OR MINIMALLY INVASIVE PARASPINAL SYMPATHETIC ABLATION FOR THE TREATMENT OF RESISTANT HYPERTENSION - A method of ablating the sympathetic ganglionic cell bodies in the thoracic paravertebral space is provided. The method includes ablating the sympathetic ganglionic cell bodies in the thoracic paravertebral space through a posterior, non-invasive or minimally invasive approach for the treatment of resistant hypertension. The ablation may additionally involve various permutations of the gray and white rami and the dorsal root ganglion in addition to the sympathetic chain ganglionic cell bodies, all located in the triangular paravertebral space. | 11-07-2013 |
20130296836 | SYSTEM AND METHOD OF PRE-AORTIC GANGLION ABLATION - A method of modulating a physiological parameter of a patient is provided. The method includes disabling one or more pre-aortic ganglion cells within a pre-aortic ganglion and improving the physiological parameter. The method further includes destroying a pre-aortic ganglion cell to prevent regeneration. | 11-07-2013 |
20130302445 | APPARATUS AND METHOD FOR TREATING CEREBRAL ISCHEMIA USING NON-INHALED CARBON DIOXIDE - A non-invasive method of treating cerebral ischemia, involving the use of non-inhaled, intra-nasally delivered carbon dioxide (CO2), alone or in combination with other gases to augment cerebral perfusion and improve outcome following a stroke is provided. A vasodilator gas is delivered intranasally, alone or in combination with a second gas, for prolonged periods of time without systemic absorption. The second gas may be selected from NO, hydrogen, xenon, anesthetic gases, oxygen, nitrogen, nitrous oxide, carbon monoxide, or air. The treatment selectively increases cerebral perfusion and provides neuroprotection in the treatment of cerebral ischemia. | 11-14-2013 |
20130331813 | SYSTEM AND METHOD OF TRANS-ABDOMINAL PRE-AORTIC GANGLION ABLATION - A method of modulating a physiological parameter of a patient by percutaneously or transcutaneously disabling one or more pre-aortic ganglion cells within a pre-aortic ganglion via the anterior abdominal wall and improving the physiological parameter is provided. The pre-aortic ganglion cells may be disabled by applying radiofrequency, high intensity or low intensity focused ultrasound. | 12-12-2013 |
20130331915 | DEVICES FOR COOLING THE NASAL CAVITY - A method for cerebral cooling is described using a cooling assembly, which includes first and second elongate tubular members adapted for insertion into a nasal cavity of a patient through the patient's nostrils. The elongate tubular members each have a proximal end, a distal end, a lumen extending therebetween, and a plurality of ports in fluid communication with the lumen. The cooling assembly also includes a manifold and a reservoir, which contains a pressurized fluid that includes a propellant having a boiling point less than 22° C. The elongate tubular members are inserted into the nasal cavity through the patient's nostrils and pressurized fluid is delivered onto a surface of the nasal cavity by infusing the pressurized fluid from the reservoir through the manifold, into the lumens and through the plurality of ports of the first and second elongate tubular members. | 12-12-2013 |
20140088562 | SYSTEM AND METHOD OF PRE-AORTIC GANGLION ABLATION - A method of modulating a physiological parameter of a patient is provided. The method includes disabling one or more pre-aortic ganglion cells within a pre-aortic ganglion and improving the physiological parameter. The method further includes destroying a pre-aortic ganglion cell to prevent regeneration. | 03-27-2014 |
20150066056 | CLAMP DEVICE FOR MINIMALLY INVASIVE PROCEDURES AND USES THEREOF - Provided herein is a clamp device that can be used in minimally invasive procedures, including surgeries such as laparoscopic surgeries, for clamping a tissue or an organ or a portion of a tissue or organ. Also provided herein are methods of clamping a tissue or an organ or a portion thereof during minimally invasive surgery using the clamp device provided herein. Also provided are systems for performing a minimally invasive surgery that include the clamp device for minimally invasive surgery provided herein and an injection device configured to access an endoscopic port for the minimally invasive surgery. | 03-05-2015 |