Patent application number | Description | Published |
20100197006 | MOLECULAR CIRCUITS - Disclosed herein are autonomous molecular circuits that can function in cells. The circuits can process logical operations in which one or more input cues are among the operands and produce an appropriate output. Such circuits can be implemented in living cells, e.g., eukaryotic or prokaryotic cells that have been modified to include circuit components. The molecular circuits and cells containing the circuits can be used in a variety of applications including, e.g., diagnostics, therapeutics, and protein production. | 08-05-2010 |
20110237652 | Detection and destruction of cancer cells using programmed genetic vectors - In its various embodiments, the invention provides, first, a composition comprising a vector for transfecting a cell. The vector comprises a first nucleic acid encoding an antisense agent having thereon an RNA interference target for a transcript of a gene endogenous to the cell. The vector further comprises a second nucleic acid that encodes a cell-killing agent. The second nucleic acid further comprises a sequence of nucleotides transcribable into a non-coding region of a transcript of the second nucleic acid, such that the non-coding region becomes an RNA interference target for the antisense agent. In the transfected cell, the vector operates to interfere with the expression of the cell-killing agent unless and until the vector senses certain endogenous gene signals, whereupon it releases the cell-killing agent. Second, the invention provides a method of treating a disease in a patient by killing cells responsible for the disease, the method comprising administering the vector to the patient until the disease, or a symptom thereof, is ameliorated. | 09-29-2011 |
20110257041 | BIO-FIELD PROGRAMMABLE GATE ARRAY AND BIO-PROGRAMMABLE LOGIC ARRAY: RECONFIGURABLE CHASSIS CONSTRUCTION - Aspects of the invention relate to reconfigurable chassis that allow for rapid construction and optimization of biocircuits. | 10-20-2011 |
20120027786 | GENETICALLY PROGRAMMABLE PATHOGEN SENSE AND DESTROY - Aspects of the invention relate to compositions and methods for using recombinant cells to sense and destroy specific pathogens. | 02-02-2012 |
20130171626 | METHODS OF EVALUATING GENE EXPRESSION LEVELS - Described herein are methods of evaluating the expression levels of DNA parts encoding proteins in test circuits. In particular, the methods disclosed herein are useful to evaluate the expression of an output protein regulated by a regulatory protein-genetic element pair. | 07-04-2013 |
20130202532 | MULTIPLE INPUT BIOLOGIC CLASSIFIER CIRCUITS FOR CELLS - Provided herein are high-input detector modules and multi-input biological classifier circuits and systems that integrate sophisticated sensing, information processing, and actuation in living cells and permit new directions in basic biology, biotechnology and medicine. The multi-input biological classifier circuits described herein comprise synthetic, scaleable transcriptional/post-transcriptional regulatory circuits that are designed to interrogate the status of a cell by simultaneously sensing expression levels of multiple endogenous inputs, such as microRNAs. The classifier circuits then compute whether to trigger a desired output or response if the expression levels match a pre-determined profile of interest. | 08-08-2013 |
20140105964 | MODIFIED POLYNUCLEOTIDES ENCODING AQUAPORIN-5 - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. | 04-17-2014 |
20140105965 | MODIFIED POLYNUCLEOTIDES ENCODING COPPER METABOLISM (MURR1) DOMAIN CONTAINING 1 - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. | 04-17-2014 |
20140105966 | MODIFIED POLYNUCLEOTIDES ENCODING HEPATITIS A VIRUS CELLULAR RECEPTOR 2 - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. | 04-17-2014 |
20140107189 | MODIFIED POLYNUCLEOTIDES ENCODING APOPTOSIS INDUCING FACTOR 1 - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules. | 04-17-2014 |
20140113959 | MODIFIED POLYNUCLEOTIDES ENCODING CASPASE 6 - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules. | 04-24-2014 |
20140113960 | MODIFIED POLYNUCLEOTIDES ENCODING GRANULYSIN - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules. | 04-24-2014 |
20140141067 | MODIFIED POLYNUCLEOTIDES ENCODING SEPTIN-4 - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules. | 05-22-2014 |
20140141068 | MODIFIED POLYNUCLEOTIDES ENCODING SIAH E3 UBIQUITIN PROTEIN LIGASE 1 - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules. | 05-22-2014 |
20140148589 | RAPID ASSEMBLY OF MULTIPLE ARBITRARY LENGTH DNA FRAGMENTS - Aspects herein relate to composition, and related methods, for isolating and assembling DNA molecules without intermediate cloning steps. | 05-29-2014 |
20140161873 | MODIFIED POLYNUCLEOTIDES ENCODING ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. | 06-12-2014 |
20140171485 | MODIFIED POLYNUCLEOTIDES ENCODING CD28 MOLECULE - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. | 06-19-2014 |
20140186432 | MODIFIED POLYNUCLEOTIDES ENCODING CITED4 - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. | 07-03-2014 |
20140193482 | MODIFIED POLYNUCLEOTIDES ENCODING V-MYC AVIAN MYELOCYTOMATOSIS VIRAL ONCOGENE HOMOLOG - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. | 07-10-2014 |
20140199371 | MODIFIED POLYNUCLEOTIDES ENCODING BASIC HELIX-LOOP-HELIX FAMILY, MEMBER E41 - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. | 07-17-2014 |
20140255467 | MODIFIED POLYNUCLEOTIDES ENCODING CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 4 - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. | 09-11-2014 |
20140255468 | MODIFIED POLYNUCLEOTIDES ENCODING PROGRAMMED CELL DEATH 1 - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. | 09-11-2014 |
20140315753 | ENGINEERING A HETEROGENEOUS TISSUE FROM PLURIPOTENT STEM CELLS - Aspects of the present disclosure are directed to methods and compositions for the production of heterogeneous tissue from human induced pluripotent stem (hiPS) cells. | 10-23-2014 |
20150044277 | MODIFIED POLYNUCLEOTIDES ENCODING CASPASE 3 - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. | 02-12-2015 |