Ring, CA
Aaron Ring, Menlo Park, CA US
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20140046026 | SUPERAGONISTS AND ANTAGONISTS OF INTERLEUKIN-2 - Novel human interleukin-2 (IL-2) muteins or variants thereof, and nucleic acid molecules and variants thereof are provided. Methods for producing these muteins as well as methods for stimulating the immune system of an animal are also disclosed. In addition, the invention provides recombinant expression vectors comprising the nucleic acid molecules of this invention and host cells into which expression vectors have been introduced. Pharmaceutical compositions are included comprising a therapeutically effective amount of a human IL-2 mutein of the invention and a pharmaceutically acceptable carrier. The IL-2 muteins can be used in pharmaceutical compositions for use in treatment of cancer and in stimulating the immune response. | 02-13-2014 |
Aaron Ring, Palo Alto, CA US
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20150368339 | MUSCARINIC ACETYLCHOLINE RECEPTOR BINDING AGENTS AND USES THEREOF - Agents that specifically bind to a muscarinic acetylcholine receptor in a conformationally-specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure based drug design. | 12-24-2015 |
Aaron Michael Ring, Palo Alto, CA US
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20150071905 | High Affinity Sirp-Alpha Reagents - High affinity SIRP-α reagent are provided, which (i) comprise at least one amino acid change relative to the wild-type protein; and (ii) have an increased affinity for CD47 relative to the wild-type protein. Compositions and methods are provided for modulating phagocytosis in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity SIRPα reagent, which blocks the physiological binding interaction between SIRPα and its ligand CD47. | 03-12-2015 |
20150355200 | Method for Selecting Agents that Bind to Transmembrane Receptors in a Conformationally-Selective Manner - Provided herein are several methods for selecting agents that bind to transmembrane receptors in a conformationally-selective way. In some embodiments, the method may comprise producing: a transmembrane receptor in an active conformation; and said transmembrane receptor in an inactive conformation and using cell sorting to select, from a population of cells comprising a library of cell surface-tethered extracellular capture agents, cells that are specifically bound to either the transmembrane receptor in its active conformation or the transmembrane receptor in its inactive conformation, but not both. In other embodiments, the method may comprise: contacting a GPCR with a population of cells that comprise a library of surface-tethered extracellular proteins; labeling the cell population with a conformationally-specific binding agent, e.g., a G-protein or mimetic thereof; and using cell sorting to select from the cell population cells that bind to the agent. | 12-10-2015 |
Brian Z Ring, Aliso Viejo, CA US
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20150141278 | MULTIPLEXED ASSAY METHOD FOR LUNG CANCER CLASSIFICATION - A method for providing a composite image of a single biological sample from a patient suspected of having lung cancer, comprising the steps of generating a first image of the biological sample, generating a second image of the biological sample, and generating a composite image that provides the relative location of both the targeted proteins. Also provided is a method of analyzing a biological sample, comprising providing a composite image of the biological sample according to the method for providing a composite image, and analyzing the expression of the protein of interest from the composite image. Further provided are method for classification of lung cancer, as well as system and kit that comprise the means for executing the novel methods. | 05-21-2015 |
Brian Z. Ring, Foster City, CA US
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20080199891 | Reagents and Methods For Use In Cancer Diagnosis, Classification and Therapy - Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents and methods for the treatment of cancer. | 08-21-2008 |
20090155798 | TLE3 AS A MARKER FOR CHEMOTHERAPY - Methods of using TLE3 as a marker for predicting the likelihood that a patient's cancer will respond to chemotherapy. Methods of using TLE3 as a marker for selecting a chemotherapy for a cancer. | 06-18-2009 |
20100062444 | TLE3 AS A MARKER FOR CHEMOTHERAPY - Methods of using TLE3 as a marker for predicting the likelihood that a patient's cancer will respond to chemotherapy. Methods of using TLE3 as a marker for selecting a chemotherapy for a cancer. | 03-11-2010 |
20100143947 | REAGENTS AND METHODS FOR USE IN CANCER DIAGNOSIS, CLASSIFICATION AND THERAPY - Methods and reagents for classifying HER2+ breast tumors and for identifying new HER2+ breast tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents and methods for the treatment of HER2+ breast cancer. | 06-10-2010 |
20110003709 | REAGENTS AND METHODS FOR USE IN CANCER DIAGNOSIS, CLASSIFICATION AND THERAPY - Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents and methods for the treatment of cancer. | 01-06-2011 |
20110015259 | TLE3 AS A MARKER FOR CHEMOTHERAPY - Methods of using TLE3 as a marker for predicting the likelihood that a patient's cancer will respond to chemotherapy. Methods of using TLE3 as a marker for selecting a chemotherapy for a cancer. | 01-20-2011 |
20120065107 | REAGENTS AND METHODS FOR USE IN CANCER DIAGNOSIS, CLASSIFICATION AND THERAPY - Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents and methods for the treatment of cancer. | 03-15-2012 |
20130079392 | TLE3 AS A MARKER FOR CHEMOTHERAPY - Methods of using TLE3 as a marker for predicting the likelihood that a patient's cancer will respond to chemotherapy. Methods of using TLE3 as a marker for selecting a chemotherapy for a cancer. | 03-28-2013 |
20130210677 | REAGENTS AND METHODS FOR USE IN CANCER DIAGNOSIS, CLASSIFICATION AND THERAPY - Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents and methods for the treatment of cancer. | 08-15-2013 |
20150198599 | TLE3 AS A MARKER FOR CHEMOTHERAPY - Methods of using TLE3 as a marker for predicting the likelihood that a patient's cancer will respond to chemotherapy. Methods of using TLE3 as a marker for selecting a chemotherapy for a cancer. | 07-16-2015 |
Cameron T. Ring, Menlo Park, CA US
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20090043805 | VIRAL ENGINE FOR NETWORK DEPLOYMENT - A private network system operates over a public network to provide an asymmetric service to members with information from other members and non-members. The system includes central servers and databases connected via the public network to client systems of public network users. The users may be members who communicate with a private protocol or non-members who communicate with the public protocol. A process for the private service includes communication of information between users via the private service servers. The private service server implements the private service, which includes a viral engine for network deployment. Features of the viral engine include genetic algorithms, data mining, personalization, frictionless service setup, user maximization, and member-controlled privacy. A sample setup process and contact update wizard that include several viral engine features are described. | 02-12-2009 |
20100268742 | Contact Management Update Protocols - A system and a method are disclosed for synchronizing folders between one or more layers of folders. It includes selecting layers to link together, comparing folders in the selected layers using an immutable identifier, parsing the folders of each of the selected layers into fields, comparing the fields of parsed folders of the selected layers, and determining whether to synchronize the folders of the selected layers based on conflict rules triggered in response to the comparison of the fields of the parsed folders. Also disclosed is a system and method of merging two or more folders in a network into a single folder. It includes comparing entries between folders to identify duplicate entries, grouping the identified duplicate entries in each folder, generating a matrix from the duplicates grouping and assigning each matrix entry a value, and matching the matrix entries based on the assigned values to determine an extent to merge an identified duplicate entry. | 10-21-2010 |
20120101989 | Contact Management Update Protocols - Ways for synchronizing folders between one or more layers of folders are described. It includes selecting layers to link together, comparing folders in the selected layers using an immutable identifier, parsing the folders of each of the selected layers into fields, comparing the fields of parsed folders of the selected layers, and determining whether to synchronize the folders of the selected layers based on conflict rules triggered in response to the comparison of the fields of the parsed folders. Also disclosed are ways of merging two or more folders in a network into a single folder. It includes comparing entries between folders to identify duplicate entries, grouping the identified duplicate entries in each folder, generating a matrix from the duplicates grouping and assigning each matrix entry a value, and matching the matrix entries based on the assigned values to determine an extent to merge an identified duplicate entry. | 04-26-2012 |
20120191797 | Viral Engine for Network Deployment - A private network system operates over a public network to provide an asymmetric service to members with information from other members and non-members. The system includes central servers and databases connected via the public network to client systems of public network users. The users may be members who communicate with a private protocol or non-members who communicate with the public protocol. A process for the private service includes communication of information between users via the private service servers. The private service server implements the private service, which includes a viral engine for network deployment. Features of the viral engine include genetic algorithms, data mining, personalization, frictionless service setup, user maximization, and member-controlled privacy. A sample setup process and contact update wizard that include several viral engine features are described. | 07-26-2012 |
Francis J. Ring, Oceanside, CA US
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20120107181 | APPARATUS FOR SYNTHESIZING OLIGONUCLEOTIDES AND METHODS OF USE - The present invention relates to apparatus and methods for synthesizing oligonucleotides wherein a reaction zone has a variable volume based on the position of a piston, and the piston is adjusted to control the amount of headspace above solid support in the reaction zone. Methods and apparatus that limit the size or existence of the headspace are described. | 05-03-2012 |
Gary Joseph Ring, Lemon Grove, CA US
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20100133924 | COMPACT LINEAR ACTUATOR AND METHOD OF MAKING SAME - Disclosed herein are methods and apparatus for a guided single-phase or multi-phase linear motor actuator with a snap-together design. Some embodiments include the ability to monitor and/or adjust work being done, yet with a cost that is comparable to that of cams or pneumatic devices. In one embodiment, a coil is attached to a bobbin assembly that is secured behind a piston. To prevent rotation of the piston during operation, a spline bearing may be slidably fitted onto one or more grooves of a spline shaft disposed within the piston assembly. One or more cylindrical magnets surrounding the coil actuate the piston based upon the direction that current is traveling through the coil. Since the electromotive force generated is linear with respect to the spline shaft, unwanted lateral force acting upon the spline shaft can be reduced and/or eliminated. | 06-03-2010 |
Karen Ring, San Francisco, CA US
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20120269778 | METHODS OF GENERATING NEURAL STEM CELLS - The present disclosure provides methods of generating neural stem cells from differentiated somatic cells. The present disclosure also provides induced neural stem cells generated using a subject method, as well as differentiated cells generated from a subject induced neural stem cell. A subject neural stem cell, as well as differentiated cells derived from a subject neural stem cell, is useful in various applications, which are also provided in the present disclosure. | 10-25-2012 |
20150017139 | Methods of Generating Neural Stem Cells - The present disclosure provides methods of generating neural stem cells from differentiated somatic cells. The present disclosure also provides induced neural stem cells generated using a subject method, as well as differentiated cells generated from a subject induced neural stem cell. A subject neural stem cell, as well as differentiated cells derived from a subject neural stem cell, is useful in various applications, which are also provided in the present disclosure. | 01-15-2015 |
Kenneth M. Ring, Tustin, CA US
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20090203183 | Method for integrating SIGE NPN and Vertical PNP Devices - According to one exemplary embodiment, a method for forming an NPN and a vertical PNP device on a substrate comprises forming an insulating layer over an NPN region and a PNP region of the substrate. The method further comprises forming a buffer layer on the insulating layer and forming an opening in the buffer layer and the insulating layer in the NPN region, where the opening exposes the substrate. The method further comprises forming a semiconductor layer on the buffer layer and in the opening in the NPN region, where the semiconductor layer has a first portion situated in the opening and a second portion situated on the buffer layer in the PNP region. The first portion of the semiconductor layer forms a single crystal base of the NPN device and the second portion of the semiconductor layer forms a polycrystalline emitter of the vertical PNP device. | 08-13-2009 |
Lawrence Ring, Valencia, CA US
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20150290390 | DRUG DELIVERY DEVICE - A drug delivery device includes a blunt cannula and a reservoir. The blunt cannula has a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula. The wall has at least a first tapered region at the first end to define an opening in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula. The reservoir is connected to the second end of the blunt cannula. | 10-15-2015 |
Lawrence S. Ring, Valencia, CA US
Patent application number | Description | Published |
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20080234637 | Valves, Valved Fluid Transfer Devices and Ambulatory Infusion Devices Including The Same - Valves, valved fluid transfer devices and ambulatory infusion devices including the same. | 09-25-2008 |
20080306466 | Implantable Infusion Devices Including Apparatus For Confirming Side Port Access - Implantable infusion devices and systems with side port access detection capability and methods of detecting side port access. | 12-11-2008 |
20120323179 | Valves, Valved Fluid Transfer Devices and Ambulatory Infusion Devices Including the same - Valves, valved fluid transfer devices and ambulatory infusion devices including the same. | 12-20-2012 |
20130296786 | VALVES, VALVED FLUID TRANSFER DEVICES AND AMBULATORY INFUSION DEVICES INCLUDING THE SAME - Valves, valved fluid transfer devices and ambulatory infusion devices including the same. | 11-07-2013 |
20140088501 | IMPLANTABLE INFUSION DEVICES INCLUDING APPARATUS FOR CONFIRMING SIDE PORT ACCESS - Implantable infusion devices and systems with side port access detection capability and methods of detecting side port access. | 03-27-2014 |
20140121599 | Valves, Valved Fluid Transfer Devices and Ambulatory Infusion Devices Including The Same - Valves, valved fluid transfer devices and ambulatory infusion devices including the same. | 05-01-2014 |
20140121600 | Valves, Valved Fluid Transfer Devices and Ambulatory Infusion Devices Including The Same - Valves, valved fluid transfer devices and ambulatory infusion devices including the same. | 05-01-2014 |
20150025460 | Valves, Valved Fluid Transfer Devices and Ambulatory Infusion Devices Including The Same - Valves, valved fluid transfer devices and ambulatory infusion devices including the same. | 01-22-2015 |
20150238748 | VALVES, VALVED FLUID TRANSFER DEVICES AND AMBULATORY INFUSION DEVICES INCLUDING THE SAME - Valves, valved fluid transfer devices and ambulatory infusion devices including the same. | 08-27-2015 |
Peter Ring, San Diego, CA US
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20120056801 | METHODS AND APPARATUSES FOR GESTURE-BASED USER INPUT DETECTION IN A MOBILE DEVICE - Methods and apparatuses are provided that may be implemented in a mobile device to: determine whether the mobile device is in a gesture command input ready state based, at least in part, on a display portion of the mobile device remaining in a horizontal viewable position for a threshold period of time; with the mobile device in a gesture command input ready state, determine whether a detected movement of the mobile device represents a gesture command input; and in response to the determined gesture command input, affect a user perceivable output. | 03-08-2012 |
20150277577 | METHODS AND APPARATUSES FOR GESTURE-BASED USER INPUT DETECTION IN A MOBILE DEVICE - Methods and apparatuses are provided that may be implemented in a mobile device to: determine whether the mobile device is in a gesture command input ready state based, at least in part, on a display portion of the mobile device remaining in a horizontal viewable position for a threshold period of time; with the mobile device in a gesture command input ready state, determine whether a detected movement of the mobile device represents a gesture command input; and in response to the determined gesture command input, affect a user perceivable output. | 10-01-2015 |