Patent application number | Description | Published |
20120190728 | COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING IN A SUBJECT - Disclosed herein are compounds, compositions and methods for modulating splicing of SMN | 07-26-2012 |
20130289092 | COMPOUNDS AND METHODS FOR MODULATING INTERACTION BETWEEN PROTEINS AND TARGET NUCLEIC ACIDS - Provided herein are antisense compounds and methods for recruiting one or more non-cleaving protein to a target nucleic acid in a cell. In certain instances such recruitment of a non-cleaving protein alters the function or activity of the target nucleic acid. In certain such instances, the target nucleic acid a pre-mRNA and the recruitment of the non-cleaving protein results in a change in splicing of the pre-mRNA. | 10-31-2013 |
20140114057 | ANTISENSE COMPOUNDS TARGETING GENES ASSOCIATED WITH USHER SYNDROME - The present invention provides compounds comprising oligonucleotides complementary to an Usher transcript. Certain such compounds are useful for hybridizing to an Usher transcript, including but not limited, to an Usher transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the Usher transcript. In certain such embodiments, the Usher transcript includes a mutation that results in cryptic splicing and hybridization of the oligonucleotide results in a decrease in the amount of cryptic splicing. In certain embodiments, such compounds are used to treat Usher Syndrome. | 04-24-2014 |
20140357558 | COMPOSITIONS AND METHODS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY - Disclosed herein are compounds, compositions and methods for treatment of diseases and disorders, including spinal muscular atrophy. | 12-04-2014 |
20150025231 | COMPOSITIONS AND METHODS FOR MODULATION OF IKBKAP SPLICING - The present disclosure provides compounds comprising oligonucleotides complementary to a portion of the IKBKAP gene. Certain such compounds are useful for hybridizing to a portion of the IKBKAP gene, including but not limited to a portion of the IKBKAP gene in a cell. In certain embodiments, such hybridization results in modulation of splicing of the IKBKAP gene. In certain embodiments, the IKBKAP gene includes a mutation that results in defective splicing and a truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in a decrease in the amount of defective splicing and truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in an increase in the amount of normal splicing and functional, full-length IKAP protein. In certain embodiments, oligonucleotides are used to treat Familial Dysautonomia. | 01-22-2015 |
Patent application number | Description | Published |
20080249308 | Complexes of Ruthenium with 2-(Aminomethyl)Pyridines and Phosphines, their Preparation and Use as Catalysts - The invention relates to a new class of ruthenium (II) complexes containing as ligands 2-(aminomethyl)pyridines and phosphines, proven to be extremely active catalysts in the reduction of ketones to alcohols via hydrogen transfer. By using 2-propanol as the hydrogen source with the ruthenium complexes, high yields of the corresponding alcohol can be rapidly obtained starting from linear and cyclic alkyl aryl, dialkyl and diaryl ketones. The conversion of ketones to alcohols can reach 100% if operating in a gaseous hydrogen atmosphere (2-3 atm). Where the phosphines used are optically active, starting from prochiral ketone compounds various types of optically active alcohols can be produced, being important intermediates in the pharmaceutical industry, in the agrochemical industry and for fine chemicals generally. | 10-09-2008 |
20100152448 | LIGANDS OF THE BENZO [H] QUINOLINE CLASS AND TRANSITION METAL COMPLEXES CONTAINING THEM AND USE OF SAID COMPLEXES AS CATALYSTS - A new class of ligands derived from benzo[h]quinoline are described and these ligands are used to prepare several novel transition metal complexes. The complexes are preferably of the group VIII transition metals iron, ruthenium or osmium, with the benzo[h]quinoline ligands acting as tridentate ligands. The complexes described are proved to be very active catalysts for the reduction of ketones and aldehydes to alcohols, via hydrogen transfer and hydrogenation reactions. These compounds hence can be usefully employed as catalysts in said reduction reactions. | 06-17-2010 |
20140179923 | NEW LIGANDS OF THE BENZO[H]QUINOLINE CLASS AND TRANSITION METAL COMPLEXES CONTAINING THEM AND USE OF SAID COMPLEXES AS CATALYSTS - A new class of ligands derived from benzo[h]quinoline are described and these ligands are used to prepare several novel transition metal complexes. The complexes are preferably of the group VIII transition metals iron, ruthenium or osmium, with the benzo[h]quinoline ligands acting as tridentate ligands. The complexes described are proved to be very active catalysts for the reduction of ketones and aldehydes to alcohols, via hydrogen transfer and hydrogenation reactions. These compounds hence can be usefully employed as catalysts in said reduction reactions. | 06-26-2014 |
Patent application number | Description | Published |
20110017377 | OPTIMIZED LOAD-BEARING STRUCTURE FOR BEARING SUPPORT AND OPTIMIZED BEARING SUPPORT - A load-bearing structure for a bearing support intended to be mounted on a rim inside a tire fitted on a vehicle to support the tread of the tire in the event of a loss of inflation pressure is provided. The load-bearing structure includes a base, a crown, and an annular body connecting the base and the crown. The body includes a plurality of partitions distributed regularly circumferentially, extending axially substantially from one side to the other of the body and radially from the base to the crown with a mean orientation relative to the radial direction of between 10 and 50 degrees, in that two circumferentially adjacent partitions exhibit contrary orientations relative to the radial direction and in that two adjacent partitions define with the base and/or the crown cavities in the form of triangles or trapezoids. | 01-27-2011 |
20140290204 | METHOD OF MANUFACTURING A TWO-LAYER METAL CORD RUBBERIZED IN SITU USING AN UNSATURATED THERMOPLASTIC ELASTOMER - A method of manufacturing a metal cord with two concentric layers of wires is provided. The cord includes an internal layer of M wires, M having a value from 1 to 4, and an external layer of N wires. The cord is rubberized from within in situ. That is, during manufacture of the cord, the cord is rubberized from inside. According to the method, the internal layer is sheathed with rubber or a rubber compound by passing the internal layer through an extrusion head, and the N wires of the external layer are assembled around the sheathed internal layer to form a two-layer cord rubberized from the inside. The rubber is an unsaturated thermoplastic elastomer that is extruded in a molten state, and preferably is a thermoplastic styrene (TPS) type of thermoplastic elastomer, such as an SBS or an SIS block copolymer, for example. | 10-02-2014 |
20140311120 | TWO-LAYERED METAL CORD RUBBERIZED IN SITU BY AN UNSATURATED THERMOPLASTIC ELASTOMER - Metal cord (C-1) with two concentric layers (Ci, Ce) of M+N construction, comprising an internal first layer or core (Ci) made up of M wire(s) (10) of diameter d | 10-23-2014 |
20150030851 | COMPOSITE REINFORCER SHEATHED WITH A RUBBER SELF-ADHESIVE POLYMER LAYER - A composite reinforcer capable of adhering directly to a diene rubber matrix, which can be used in particular as a reinforcing element for a tyre, comprises: one or more reinforcing thread(s), for example a thread or cord made of carbon steel; and a layer of a polymer composition which covers the said thread, individually each thread or collectively several threads, this layer comprising at least one thermoplastic polymer, the glass transition temperature of which is positive, such as, for example, a polyamide, and an epoxidized diene elastomer, such as, for example, natural rubber or a butadiene homopolymer or copolymer. A process for the manufacture of such a composite reinforcer, and a finished article or semi-finished product made of rubber, in particular a tyre, incorporating such a composite reinforcer are also disclosed. | 01-29-2015 |
Patent application number | Description | Published |
20130177764 | Composite Reinforcement - Composite reinforcer (R- | 07-11-2013 |
20130220505 | Multi-Layered Metal Cord Rubberized in Situ by an Unsaturated Thermoplastic Elastomer - Metal cord with a plurality of concentric layers, of the type rubberized in situ, i.e. a cord that is rubberized from the inside, during its actual manufacture, with a rubber known as a filling rubber, in which all or some of the gaps situated between the wires of the cord contain a thermoplastic elastomer of the unsaturated type, particularly an unsaturated thermoplastic stirene (TPS) elastomer such as an SBS, SBBS, SIS or SBIS block copolymer for example. Such a thermoplastic elastomer, used in the molten state, presents no problems of parasitic stickiness if the filling rubber overspills out of the cord following manufacture; its unsaturated and therefore (co)vulcanizable nature makes it extremely compatible with the diene rubber matrices, notably natural rubber matrices as conventionally used as calendering rubber in the metal fabrics intended for reinforcing tires. | 08-29-2013 |
20130220506 | Triple-Layered Metal Cord Rubberized in Situ by an Unsaturated Thermoplastic Elastomer - Metal cord with three concentric layers including a first layer of diameter d | 08-29-2013 |
20130227924 | Method for the Production of a Multi-Layer Metal Cord that is Rubberized in Situ using an Unsaturated Thermoplastic Elastomer - Method of manufacturing a multi-layer metal cord having a plurality of concentric layers of wires, comprising one or more inner layer(s) and an outer layer, of the type “rubberized in situ.” The method includes the following steps: at least one step of sheathing at least one inner layer with the rubber or the rubber composition by passing through at least one extrusion head; and an assembling step in which the wires of the outer layer are assembled around the inner layer adjacent to it, in order to form the multi-layer cord thus rubberized from the inside. The rubber is an unsaturated thermoplastic elastomer extruded in the molten state, preferably a thermoplastic elastomer of the thermoplastic stirene (TPS) elastomer type such as an SBS, SBBS, SIS or SBIS block copolymer for example. | 09-05-2013 |
20130232936 | Method for the Production of a Three-Layer Metal Cord of the Type that is Rubberized in Situ - Method for manufacturing a metal cord with three concentric layers including a first layer of diameter d | 09-12-2013 |
20130273366 | Composite Reinforcement and Manufacturing Process Therefor - Composite reinforcer (R- | 10-17-2013 |
20130280511 | Tire Cover Comprising a Self-Adherent Composite Reinforcement - Pneumatic tire comprising a composite reinforcer (R-2) that is self-adhesive by curing to a diene rubber matrix, comprising: one or more reinforcing thread(s) ( | 10-24-2013 |
20140045983 | COMPOSITE REINFORCER SHEATHED WITH A LAYER OF POLYMER THAT IS SELF-ADHESIVE TO RUBBER - Composite reinforcer (R-2) capable of adhering directly to a diene rubber matrix, which can be used as a reinforcing element for a pneumatic tyre, comprising:
| 02-13-2014 |
20140045984 | Auto-Adhesive Composite Reinforcement - Composite reinforcer (R- | 02-13-2014 |
20140190604 | PNEUMATIC TYRE PROVIDED WITH A TREAD BASED ON A THERMOPLASTIC ELASTOMER - The present invention relates to a tyre provided with a tread, such that the tread comprises at least one thermoplastic elastomer, which is a block copolymer comprising at least one elastomer block and at least one thermoplastic block, and hollow microparticles. | 07-10-2014 |
Patent application number | Description | Published |
20130220505 | Multi-Layered Metal Cord Rubberized in Situ by an Unsaturated Thermoplastic Elastomer - Metal cord with a plurality of concentric layers, of the type rubberized in situ, i.e. a cord that is rubberized from the inside, during its actual manufacture, with a rubber known as a filling rubber, in which all or some of the gaps situated between the wires of the cord contain a thermoplastic elastomer of the unsaturated type, particularly an unsaturated thermoplastic stirene (TPS) elastomer such as an SBS, SBBS, SIS or SBIS block copolymer for example. Such a thermoplastic elastomer, used in the molten state, presents no problems of parasitic stickiness if the filling rubber overspills out of the cord following manufacture; its unsaturated and therefore (co)vulcanizable nature makes it extremely compatible with the diene rubber matrices, notably natural rubber matrices as conventionally used as calendering rubber in the metal fabrics intended for reinforcing tires. | 08-29-2013 |
20130220506 | Triple-Layered Metal Cord Rubberized in Situ by an Unsaturated Thermoplastic Elastomer - Metal cord with three concentric layers including a first layer of diameter d | 08-29-2013 |
20130227924 | Method for the Production of a Multi-Layer Metal Cord that is Rubberized in Situ using an Unsaturated Thermoplastic Elastomer - Method of manufacturing a multi-layer metal cord having a plurality of concentric layers of wires, comprising one or more inner layer(s) and an outer layer, of the type “rubberized in situ.” The method includes the following steps: at least one step of sheathing at least one inner layer with the rubber or the rubber composition by passing through at least one extrusion head; and an assembling step in which the wires of the outer layer are assembled around the inner layer adjacent to it, in order to form the multi-layer cord thus rubberized from the inside. The rubber is an unsaturated thermoplastic elastomer extruded in the molten state, preferably a thermoplastic elastomer of the thermoplastic stirene (TPS) elastomer type such as an SBS, SBBS, SIS or SBIS block copolymer for example. | 09-05-2013 |
20130232936 | Method for the Production of a Three-Layer Metal Cord of the Type that is Rubberized in Situ - Method for manufacturing a metal cord with three concentric layers including a first layer of diameter d | 09-12-2013 |
20130273366 | Composite Reinforcement and Manufacturing Process Therefor - Composite reinforcer (R- | 10-17-2013 |
20130280511 | Tire Cover Comprising a Self-Adherent Composite Reinforcement - Pneumatic tire comprising a composite reinforcer (R-2) that is self-adhesive by curing to a diene rubber matrix, comprising: one or more reinforcing thread(s) ( | 10-24-2013 |