Ravi K.
Ravi K. Amaravadi, Media, PA US
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20140050696 | NOVEL BISAMINOQUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS PREPARED THEREFROM AND THEIR USE - The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods of treating cancer in patients in need using compounds and/or compositions according to the present invention alone or in combination with at least one additional anticancer agent represent additional aspects of the invention. Methods of treating disease states and/or conditions in which inhibition of autophagy plays a favorable treatment role including rheumatoid arthritis, malaria, antiphospholipid antibody syndrome, lupus, chronic urticaria and Sjogren's disease, with compounds according to the present invention represent additional aspects of the invention. | 02-20-2014 |
20150233930 | METHODS AND COMPOSITIONS EMPLOYING SECRETED PROTEINS THAT REFLECT AUTOPHAGY DYNAMICS WITHIN TUMOR CELLS - A diagnostic reagent or device for determining the autophagy levels of cancer cells comprises a ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying a biomarker selected from IL-8, IL-1β, DKK-3, FAM-3C and/or LIF, or an isoform, pro-form, modified molecular form including posttranslational modification, or unique peptide fragment or nucleic acid fragment thereof. Another reagent contains ligands to two or more of these biomarkers. Optionally, such reagent or device includes a signaling molecule and/or a substrate on which the ligand is immobilized. Other reagents are useful in methods of measuring autophagy of cancer cells, e.g., melanoma and for monitoring cancer progression, chemoresistance, or predicting likely candidates for treatment with autophagy inhibitors. | 08-20-2015 |
Ravi K. Anchoori, Elkridge, MD US
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20160106725 | Novel bis-Benzylidine Piperidone Proteasome Inhibitor with Anticancer Activity - We describe a bis-benzylidine piperidone, RA190, which covalently binds to the ubiquitin receptor RPN13 (ADRM1) in the 19S regulatory particle and inhibits proteasome function, triggering rapid accumulation of polyubiquitinated proteins. Multiple myeloma lines, even those resistant to bortezomib, were sensitive to RA190 via ER stress-related apoptosis. RA190 stabilized targets of human papillomavirus (HPV) E6 oncoprotein, and preferentially killed HPV-transformed cells. After p.o. or i.p. dosing of mice, RA190 distributed to plasma and major organs excepting brain, and potently inhibited proteasome function in skin and muscle. RA190 administration i.p. profoundly reduced growth of multiple myeloma and ovarian cancer xenografts, and oral RA190 treatment retarded HPV+ syngeneic mouse tumor growth, without impacting spontaneous HPV-specific CD8+ T cell responses, suggesting its therapeutic potential. The bis-benzylidine piperidone RA190 is a new orally-available proteasome inhibitor. Multiple myeloma, cervical and ovarian cancers are particularly sensitive to RA190. | 04-21-2016 |
Ravi K. Armilli, Austin, TX US
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20090198906 | Techniques for Multi-Level Indirect Data Prefetching - A technique for performing data prefetching using multi-level indirect data prefetching includes determining a first memory address of a pointer associated with a data prefetch instruction. Content that is included in a first data block (e.g., a first cache line of a memory) at the first memory address is then fetched. A second memory address is then determined based on the content at the first memory address. Content that is included in a second data block (e.g., a second cache line) at the second memory address is then fetched (e.g., from the memory or another memory). A third memory address is then determined based on the content at the second memory address. Finally, a third data block (e.g., a third cache line) that includes another pointer or data at the third memory address is fetched (e.g., from the memory or the another memory). | 08-06-2009 |
Ravi K. Birla, Ann Arbor, MI US
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20100196322 | POLYMER FOR TISSUE ENGINEERING APPLICATIONS AND DRUG DELIVERY - A biocompatible and biodegradable elastomeric polymer material, the polymer material comprising: glycerol and dodecanedioic acid, wherein the molar ratio of glycerol to dodecanedioic acid is from about 5:1 to about 1:5. Methods for using the biocompatible and biodegradable elastomeric polymer material comprises providing an PGD elastomeric polymer comprising glycerol and dodecanedioic acid, in a molar ratio of glycerol to dodecanedioic acid of about 1:1 and administering the PGD elastomeric polymer to a soft tissue defect site in needs thereof. | 08-05-2010 |
Ravi K. Birla, Sugar Land, TX US
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20140328806 | ENERGETIC THREE-DIMENSIONAL ARTIFICIAL CARDIAC PATCH AND USES THEREOF - In some embodiments, the present disclosure provides a method for fabricating a three-dimensional artificial cardiac patch construct. In some embodiments, such method includes the steps of coating a substrate with an organic polymer; allowing the organic polymer coating to air dry; mounting anchors on the organic polymer coating; and sterilizing the organic polymer coating and the anchors. In further embodiments, the method includes the steps of forming a biodegradable gel-based support scaffold on top of the organic polymer coating and seeding the biodegradable gel-based support scaffold with neonatal cardiac cells. In yet further embodiments, the method comprises culturing the neonatal cardiac cells in vitro to form a real cardiac layer, under culture conditions that are suitable for the cells to self-organize into a monolayer and detach from the substrate to form the three-dimensional cardiac patch. In some embodiments, the present disclosure pertains to a method of treatment of cardiac tissue injury in a subject in need thereof. In some embodiments, the method includes implanting the three-dimensional artificial cardiac patch described above in the injured area of the subject. In another embodiment the present disclosure provides a composition comprising the three-dimensional artificial cardiac patch described above. Additional embodiments of the present disclosure pertain to a medicament including the three-dimensional artificial cardiac patch described above. | 11-06-2014 |
20150335417 | TWO STAGE CELLULARIZATION STRATEGY FOR THE FABRICATION OF BIOARTIFICIAL HEARTS - In some embodiments, the present disclosure pertains to a method of fabricating an artificial heart muscle (AHM) patch. In some embodiments, the method comprises obtaining and/or isolating cells from a subject. In some embodiments, the cells are primary cardiac cells. In some embodiments, the method further comprises forming a scaffold. In some embodiments, the method comprises seeding the cells in the fibrin gel scaffold. In some embodiments, the method comprises culturing the cells seeded in the fibrin gel scaffold under conditions appropriate for the formation of an artificial heart muscle (AHM) patch. In some embodiments, the present disclosure pertains to a method of fabricating a bioartificial heart (BAH). In some embodiments, the present disclosure pertains to a method of treatment of cardiac tissue injury in a subject in need thereof. In some embodiments, the method includes implanting the aforementioned artificial heart muscle patch in the injured area of the subject. In some embodiments, the present disclosure relates to a method of treating end stage cardiac disease in a subject in need thereof. | 11-26-2015 |
Ravi K. Dasaka, Danbury, CT US
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20150349121 | ASYMMETRIC STRESSOR DRAM - A stressor structure is formed within a drain region of an access transistor in a dynamic random access memory (DRAM) cell in a semiconductor-on-insulator (SOI) substrate without forming any stressor structure in a source region of the DRAM cell. The stressor structure induces a stress gradient within the body region of the access transistor, which induces a greater leakage current at the body-drain junction than at the body-source junction. The body potential of the access transistor has a stronger coupling to the drain voltage than to the source voltage. An asymmetric etch of a gate dielectric cap, application of a planarization material layer, and a non-selective etch of the planarization material layer and the gate dielectric cap can be employed to form the DRAM cell. | 12-03-2015 |
Ravi K. Desu, Irvine, CA US
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20100146531 | ESTIMATING REACH AND FREQUENCY OF ADVERTISEMENTS - Estimating the reach and device frequency of a proposed advertising campaign based on the probability that advertising content delivery devices (e.g., a television set top box, radio) were used to deliver advertising content (e.g. television ad, radio ad) during specific time periods on specific delivery device channels. | 06-10-2010 |
20120079519 | ESTIMATING REACH AND FREQUENCY OF ADVERTISEMENTS - Estimating the reach and device frequency of a proposed advertising campaign based on the probability that advertising content delivery devices (e.g., a television set top box, radio) were used to deliver advertising content (e.g. television ad, radio ad) during specific time periods on specific delivery device channels. | 03-29-2012 |
Ravi K. Gananathan, Richmond Hill CA
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20120177303 | Apparatus And Method For Creation Of Digital Art Forms From Other Digital Data - Apparatus and method for creation or transformation of digital art forms in 2D/3D images, photos, video, music, voice, etc. based on messages received on or sent from mobile or PC devices via email, SMS, Tweets and other messaging services, as well as other forms of accessible or streaming data such as voice calls, web page data, user input data such as button pushes, other downloadable or downloaded content including analog media converted to digital data, i.e. bit streams of any kind as input. There are no solutions today that use data from other sources as input to create new digital art forms or transform other existing digital art forms. | 07-12-2012 |
Ravi K. Kanipayor, London CA
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20130125673 | SYSTEMS AND METHODS FOR PREPARING SAMPLES FOR CHEMICAL ANALYSIS - A system for preparing samples for chemical analysis comprises at least one sample container, and a container receptacle apparatus for receiving the sample container. The sample container comprises an elongate tubular body having a crucible portion proximal to a closed end for receiving a sample therein, and an expansion portion proximal to an open end. The container receptacle apparatus comprising a housing having a heating compartment, a cooling compartment spaced apart from the heating compartment, and an insulating region located between the heating compartment and the cooling compartment. The heating compartment is shaped to receive the crucible portion of the sample container, and the cooling compartment is shaped to receive the expansion portion of the sample container. The apparatus also includes a heating mechanism for heating the sample within the crucible portion of the sample container, and a cooling mechanism for cooling the expansion portion of the sample container. | 05-23-2013 |
20140377880 | SYSTEMS AND METHODS FOR PREPARING SAMPLES FOR CHEMICAL ANALYSIS USING A COOLED DIGESTION ZONE - An apparatus for preparing samples for chemical analysis includes a container receptacle for receiving a sample container having a crucible portion and an expansion portion. The container receptacle includes a heating compartment and a cooling compartment spaced apart from the heating compartment. The heating compartment is shaped to receive the crucible portion of the sample container, and the cooling compartment is shaped to receive the expansion portion of the sample container. The apparatus also includes a heating mechanism for heating the sample within the crucible portion of the sample container, a first cooling mechanism for cooling the expansion portion of the sample container, and a second cooling mechanism for cooling the crucible portion of the sample container. | 12-25-2014 |
20150160106 | SYSTEMS AND METHODS FOR PREPARING SAMPLES FOR CHEMICAL ANALYSIS - A system for preparing samples for chemical analysis comprises at least one sample container, and a container receptacle apparatus for receiving the sample container. The sample container comprises an elongate tubular body having a crucible portion proximal to a closed end for receiving a sample therein, and an expansion portion proximal to an open end. The container receptacle apparatus comprising a housing having a heating compartment, a cooling compartment spaced apart from the heating compartment, and an insulating region located between the heating compartment and the cooling compartment. The heating compartment is shaped to receive the crucible portion of the sample container, and the cooling compartment is shaped to receive the expansion portion of the sample container. The apparatus also includes a heating mechanism for heating the sample within the crucible portion of the sample container, and a cooling mechanism for cooling the expansion portion of the sample container. | 06-11-2015 |
Ravi K. Kummaraguntla, Austin, TX US
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20130082780 | ACCURACY POWER DETECTION UNIT - Techniques are disclosed relating to radio frequency (RF) power detection. In one embodiment, a power detection unit is disclosed that includes a multiplier circuit configured to receive a first voltage of a voltage differential signal at gates of a first transistor pair and a second voltage of the voltage differential signal at gates of a second transistor pair. The first multiplier is configured to output a current that varies proportionally to a square of a voltage difference between the first and second voltages. In some embodiments, sources of the first transistor pair are coupled to sources of the second transistor pair, and the sources of the second transistor pair are coupled together. In some embodiments, the power detection unit is configured to compensate for mismatched transistors by applying offset voltages to bodies of transistors in the first and second transistor pairs. | 04-04-2013 |
Ravi K. Laveti, Hyderabad IN
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20140140837 | FLOW CONDITIONING FEATURE FOR SUCTION DIFFUSER - A suction diffuser or arrangement is provided featuring a main suction diffuser body and a flow conditioning arrangement. The main suction diffuser body is configured with an inlet to receive an incoming fluid flow, an interior cavity to receive the incoming fluid from the inlet, and an outlet to receive the incoming fluid from the interior cavity and provide an outgoing fluid. The flow conditioning arrangement is configured in relation to the inlet and also comprises a flow conditioning portion having at least one inwardly contoured surface, configured to extend into the interior cavity, diffuse the incoming fluid passing from the inlet into the interior cavity, and provide a flow conditioning that produces a uniform flow of the outgoing fluid by directing the incoming fluid towards the outlet, based at least partly on a contoured design corresponding to the at least one inwardly contoured surface. | 05-22-2014 |
Ravi K. Nareppa, Rochester, NY US
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20130257869 | METHOD FOR ENHANCING RECONSTRUCTED 3-D TOMOSYNTHESIS VOLUME IMAGE - A method for providing tomosynthesis 3-D volume image data, executed at least in part on a computer, acquires a number of radiographic projection images of a subject over a range of angles. Reconstructed volume image data is generated from the acquired projection images. A number of regions of interest are defined within the reconstructed volume image data, wherein each region of interest has a number of image voxels. Image voxel data values are conditioned within at least one of the regions of interest to enhance contrast within the at least one region of interest. The conditioned image voxel data values are adjusted within the at least one of the regions of interest according to interpolation with two or more neighboring regions of interest. An image slice having at least a plurality of the adjusted image voxel data values is displayed. | 10-03-2013 |
Ravi K. Palakodety, Redwood City, CA US
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20110106797 | DOCUMENT RELEVANCY OPERATOR - Systems, methods, and other embodiments associated with document relevancy are described. One example method includes receiving one or more query terms from a query on stored documents. A relevancy operator is run on a document clump that applies more than one type of matching operation between the query terms and the document clump in a single pass. The relevancy operator may also apply at least one heuristic on the document clump in a single pass. A document's relevancy to the query is predicted based, at least in part, on an output of the relevancy operator. | 05-05-2011 |
Ravi K. Saggar, Blue Ash, OH US
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20090255847 | Flexible Package with Opening Means - A flexible package for accommodating a multiplicity of articles, wherein the package comprises at least a side wall with an opening means. The opening means comprises a gripping means and a tearing means and the gripping means is formed in an external panel of the side wall. The opening means is adapted to create an opening in the side wall by tearing a tear-off portion of the side wall. The external panel further comprises a first strap, which after opening the package, remains adjacent to an upper edge of the package. | 10-15-2009 |
Ravi K. Singh, Austin, TX US
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20140040665 | MIDDLEWARE FOR MULTIPROCESSOR SOFTWARE TESTING - An apparatus having a memory and multiple processors coupled to the memory is disclosed. The memory may be configured to store middleware. One or more processors may be configured to (a) generate initial test vectors to test one or more software modules executed on the processors and (b) generate modified test vectors by translating the initial test vectors in the middleware to a format that matches multiple hardware dependencies of the processors and multiple software dependencies of multiple operating systems. The test vectors generally have another format that is independent of (a) the hardware dependencies of the processors and (b) the software dependencies of the operating systems executed by the processors. The processors may be configured to generate a plurality of test results by exercising the software modules with the modified test vectors. | 02-06-2014 |