Poul
Gregory D. Poul, St. Paul, MN US
Patent application number | Description | Published |
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20140117055 | SYRUP DISPENSER - A dispenser according to one example includes a container portion, a collar base portion and a lever portion. The container portion includes a sidewall, a bottom surface, a hollow interior and an open top. The open top includes an upwardly extending neck. The collar base portion includes a neck receiving recess defined therein, a flow aperture defined therein, a receiving cavity defined therein, a dispensing edge defined in a forward portion thereof, an upwardly extending first pivot member, and a handle portion extending from a rearward portion thereof. The lever portion includes an elongated body having a top surface, a bottom surface, a dispensing end and an actuating end. The lever portion defines a cutoff edge adjacent the dispensing end, a second pivot member extending downwardly from the lower surface, and a biasing member extending generally downwardly from the bottom surface. | 05-01-2014 |
20140246463 | BEVERAGE DISPENSING FLOW CONTROL DEVICE AND METHOD THEREOF - A beverage dispensing flow control device according to one example includes a body portion, an actuation lever and a sealing gasket. A sealing gasket is securable over the bottom surface of the body and has a bottom surface with a beverage flow aperture and a vent aperture. The apertures are configured to define a maximum flow position when the sealing gasket is rotationally aligned with respect to the body portion such that the beverage flow aperture does not block the flow aperture of the body portion, and a minimum flow position when the sealing gasket is rotationally aligned with respect to the body portion such that the beverage flow aperture blocks at least the majority of the body's flow aperture while leaving at least a portion of the vent channel unblocked. A plunger is in operable communication with the actuation lever to selectively seal the bottom surface of the gasket. | 09-04-2014 |
Laurence Poul, Paris FR
Patent application number | Description | Published |
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20120203050 | METALLIC NANOPARTICLES, PREPARATION AND USES THEREOF - The present application relates to activable nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cells, tissues or organs. It more particularly relates to nanoparticles which can generate a significantly efficient therapeutic effect, when exposed to ionizing radiations. The inventive nanoparticle is a metallic nanoparticle having, as the largest size, a size comprised between about 80 and 105 nm, the metal having preferably an atomic number (Z) of at least 25. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses. | 08-09-2012 |
Marie Alix Poul, San Francisco, CA US
Patent application number | Description | Published |
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20090105086 | Methods of selecting internalizing antibodies - This invention provides methods of selecting antibodies that are internalized into target cells. The methods generally involve contacting target cells with one or more members of an antibody phage display library. The members of the phage display library are also contacted with cells of a subtractive cell line. The target cells are then washed to remove the subtractive cell line cells and members of the phage display library that are non-specifically bound or weakly bound to the target cells. The target cells are cultured under conditions where members of the phage display library can be internalized if bound to an internalizing marker and internalized members of the phage display library are then identified. | 04-23-2009 |
20110218333 | Internalizing ErbB2 antibodies - This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided. | 09-08-2011 |
20130337039 | Internalizing ErBB2 Antibodies - This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided. | 12-19-2013 |
Marie-Alix Poul, Montpellier FR
Patent application number | Description | Published |
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20130045206 | ANTIBODIES DIRECTED AGAINST THE TRANSFERRIN RECEPTOR AND USES THEREOF FOR IMMUNOTHERAPY OF IRON-DEPENDENT TUMOURS - The present invention relates to a molecular structure characterised in that said structure includes at least one amino acid sequence selected from: SEQ. ID NO.: 1, SEQ. ID NO.: 2, SEQ. ID NO.: 3, SEQ. ID NO.: 4, SEQ. ID NO.: 5, SEQ. ID NO.: 6, SEQ. ID NO.: 7, SEQ. ID NO.: 8, SEQ. ID NO.: 9, SEQ. ID NO.: 10, SEQ. ID NO.: 11, SEQ. ID NO.: 12, SEQ. ID NO.: 13, SEQ. ID NO.: 14, SEQ. ID NO.: 15, SEQ. ID NO.: 16, SEQ. ID NO.: 17, SEQ. ID NO.: 18, SEQ. ID NO.: 19, SEQ. ID NO.: 20, SEQ. ID NO.: 21, SEQ. ID NO.: 22, SEQ. ID NO.: 23, SEQ. ID NO.: 24, SEQ. ID NO.: 25, SEQ. ID NO.: 26, SEQ. ID NO.: 27, SEQ. ID NO.: 28, SEQ. ID NO.: 29, SEQ. ID NO.: 30, SEQ. ID NO.: 31, SEQ. ID NO.: 32, SEQ. ID NO.: 33, SEQ. ID NO.: 34, SEQ. ID NO.: 35, SEQ. ID NO.: 36, said amino acid sequence corresponding to an antigen complementarity determining region (CDR) of the variable domain of the heavy chain (CDR-H) or the light chain (CDR-L) of an antibody targeting the human transferrin receptor (TfR). The present invention also relates to a pharmaceutical composition including a therapeutically effective amount of at least one molecular structure as defined in the present application, combined with a pharmaceutically acceptable carrier. | 02-21-2013 |