Patent application number | Description | Published |
20080292047 | Method for determining presence distributions with local three-dimensional resolution for a substance in a vascular system and corresponding facilities - A computer receives a volume data set describing a vascular system with local three-dimensional resolution and a temporal sequence of groups of x-ray images. An acquisition time is assigned to each group of x-ray images comprising at least one x-ray image. Each x-ray image shows an actual presence distribution with local two-dimensional resolution for a substance in the vascular system, as defined at the respective acquisition time. The computer uses an initial presence distribution with local three-dimensional resolution for the substance, as defined for a start time, to determine further presence distributions with local three-dimensional resolution for the substance automatically for determination times by iterative resolution of fluid dynamics movement equations, which are per se location-independent. It automatically corrects the further presence distributions, if their respective determination time corresponds to one of the acquisition times, based on the temporally corresponding group of x-ray images. | 11-27-2008 |
20090074277 | Registration method with three-dimensional representation of a vascular tree as a function of blood flow - A three-dimensional volume data record contains a vascular tree. A two-dimensional projection image is an image of an actual fill state, to which the vascular tree is filled with a contrast agent at an acquisition time. The volume data record and the projection image are registered in relation to one another by means of the set of imaging parameters. A computation facility determines an expected target fill state, which describes which parts of the vascular tree should be filled with contrast agent at acquisition time in the three-dimensional volume data record. The computation facility determines the set of imaging parameters based on the target fill state and the projection image. | 03-19-2009 |
20090082990 | Method and device for determining an optimum direction of projection for recording projection images - The invention relates to a method and a device for determination of an optimum direction of projection or position for recording a number of two-dimensional projection images of an object of interest, with the two-dimensional projection images being recorded by rotation or translation of an imaging system around the object. Inventively the process is as follows: a) estimating a position of the object at a point in time; b) determining at least one optimum imaging view from which the optimum direction of projection and/or position is produced, for the position estimated under a) with the aid of previously determined measurement. Preferably the measurement is expressed as a function of a transformation which is described by a spatial object-imaging system relationship. | 03-26-2009 |
Patent application number | Description | Published |
20100312423 | METHOD AND DEVICE FOR CONTROLLING A PARALLEL HYBRID DRIVE-TRAIN OF A VEHICLE - An method for controlling a parallel hybrid drive-train of a vehicle comprising an automatic transmission and a combustion engine which is connected, via a first shifting device, to an electrical machine, which is connected, via a drive shaft, a starting clutch positioned in the transmission. To guarantee safety and high drive comfort of the vehicle during failure of the starting clutch, shifting failures of the starting clutch are monitored. If a shifting failure is recognized, predetermined contingency procedures are initiated and executed in which either continued drive of the vehicle or slowing down of the vehicle to a stop is possible. A device comprises a monitor with a sensor and parts for analyzing and recognizing shifting failures of the starting clutch. Control parts initiate and execute contingency procedures such that a continued drive operation or slowing down of the vehicle to a stop is possible. | 12-09-2010 |
20120238404 | METHOD FOR OPERATING A DRIVETRAIN - A method of operating a drive train having a hybrid drive including a combustion engine and electric motor, a clutch located between the engine and the motor, a transmission, a starting element and a brake pedal. For electric crawling from a state in which the clutch is disengaged, the brake pedal is activated and the combustion engine is turned off, initially the starting element is brought to or maintained at a filling pressure. Next, the rotational speed of the electric motor is adjusted to be higher, by a defined slippage rotational speed, than a transmission side rotational speed. When this slippage is reached, the starting element is further engaged to create a crawl torque at the output. The electric motor continues at rotational speed control so that the slippage is maintained. | 09-20-2012 |
Patent application number | Description | Published |
20100205682 | HUMANIZED IMMUNOGLOBULIN LOCI - The present invention concerns methods and means to produce humanized antibodies from transgenic non-human animals. The invention specifically relates to novel immunoglobulin heavy and light chain constructs, recombination and transgenic vectors useful in making transgenic non-human animals expressing humanized antibodies, transgenic animals, and humanized immunoglobulin preparations. | 08-12-2010 |
20110219465 | Suppression of B-Cell Apoptosis in Transgenic Animals Expressing Humanized Immunoglobulin - The invention provides a novel approach to increase immunoglobulin expression in non-human transgenic animals. For instance, the invention provides a method to increase humanized immunoglobulin production in animals genetically engineered to express one or several human or humanized immunoglobulin transloci. This can be done by overexpressing the apoptosis inhibitor, i.e. a rabbit bcl-2, whose expression is driven by a B-cell specific promoter specifically in the B-cell of the animal, thereby enhancing the survival of B-cells. This invention further relates to a method for selectively enhancing the survival of exogenous B-cells, that is B-cells expressing any immunoglobulin transgene locus, over the survival of endogenous B-cells that do not express the transgene locus. Selectivity is achieved by expressing the apoptosis-inhibitor only within exogenous B-cells, that is, by coupling exogenous immunoglobulin expression with apoptosis inhibitor expression. This latter method allows for increased expression and production of the transgene encoded product(s) over the endogenously produced immunoglobulin of the transgenic animal. The invention also provides a novel apoptosis-inhibitor, rabbit bcl-2. | 09-08-2011 |
20130084637 | SINGLE B-CELL CULTIVATION METHOD - Herein is reported a method for obtaining a B-cell comprising the following steps a) labeling B-cells, b) depositing the labeled B-cells as single cells, c) co-cultivating the single cell deposited B-cells with feeder cells, d) selecting a B-cell proliferating and secreting IgG in step c) and thereby obtaining a B-cell. The labeling can be of IgG | 04-04-2013 |
20130102072 | SUPPRESSION OF B-CELL APOPTOSIS IN TRANSGENIC ANIMALS EXPRESSING HUMANIZED IMMUNOGLOBULIN - The invention provides a novel approach to increase immunoglobulin expression in non-human transgenic animals. For instance, the invention provides a method to increase humanized immunoglobulin production in animals genetically engineered to express one or several human or humanized immunoglobulin transloci. This can be done by overexpressing the apoptosis inhibitor, i.e. a rabbit bcl-2, whose expression is driven by a B-cell specific promoter specifically in the B-cell of the animal, thereby enhancing the survival of B-cells. This invention further relates to a method for selectively enhancing the survival of exogenous B-cells, that is B-cells expressing any immunoglobulin transgene locus, over the survival of endogenous B-cells that do not express the transgene locus. Selectivity is achieved by expressing the apoptosis-inhibitor only within exogenous B-cells, that is, by coupling exogenous immunoglobulin expression with apoptosis inhibitor expression. This latter method allows for increased expression and production of the transgene encoded product(s) over the endogenously produced immunoglobulin of the transgenic animal. The invention also provides a novel apoptosis-inhibitor, rabbit bcl-2. | 04-25-2013 |
20130189774 | HUMANIZED IMMUNOGLOBULIN LOCI - The present invention concerns methods and means to produce humanized antibodies from transgenic non-human animals. The invention specifically relates to novel immunoglobulin heavy and light chain constructs, recombination and transgenic vectors useful in making transgenic non-human animals expressing humanized antibodies, transgenic animals, and humanized immunoglobulin preparations. | 07-25-2013 |
20140315252 | CD40L EXPRESSING MAMMALIAN CELLS AND THEIR USE - Herein is reported a co-cultivation system for co-cultivating a pool of rabbit B-cells or single deposited rabbit B-cells wherein cells CD40L expressing CHO cells are used as feeder in the presence of IL-2 and IL-21. | 10-23-2014 |
Patent application number | Description | Published |
20090046203 | VIDEO DATA PROCESSING APPARATUS AND METHOD FOR GENERATING A DIGITAL VIDEO DATA STREAM - The invention relates to a video data processing apparatus and a method for generating a digital video data stream. The video data processing apparatus is equipped with an input for the input of at least digital video data (vi), a processing unit for the processing of at least the input video data (vi), an output for the output of the processed video data (vi) and a control interface for interrupt and/or status data (di, ds), the processing unit and/or a data insertion unit insert the interrupt and/or status data (di, ds) into the input digital video data (vi), and the output (O) generating, as digital output data stream (vo), the input video data (vi) having the interrupt and/or status data (di, ds) placed or incorporated thereinto. | 02-19-2009 |
20100014595 | AUDIO AND/OR VIDEO DATA PROCESSING DEVICE, COMMUNICATION OR DATA NETWORK FOR TRANSCODING AUDIO AND/OR VIDEO DATA, AND METHOD FOR DECODING AUDIO AND/OR VIDEO DATA - The invention relates to an audio and/or video data processing device having at least one interface for making available audio and/or video data as coded data (dsi, dso*), and an audio-video decoder (AVD) that decodes the data (dsi, dso) coded with at least one code (k) to produce decoded data (d), and a transcoding interface (IFT) that outputs unsuitably coded data (dso*), which are coded with a code (k*) unsuitable for the audio-video decoder (AVD) to a format conversion module (TC) and for receiving transcoded coded data (dso) transcoded to a code (k) suitable for the audio-video decoder (AVD). Transcoding interface (IFT) is a network interface for communication over the data network (N) for transmitting the unsuitably coded data (dso*) to the format conversion module (TC) and the transcoded coded data (dso) from the format conversion module (TC) via the communication or data network (N). | 01-21-2010 |
20140005976 | Measuring system for registering the absolute rotation angle of a rotating, measured object | 01-02-2014 |
20140125067 | ACTUATOR WITH AN ASSEMBLY FOR ELECTRICAL MANUAL ACTUATION OF AN ACTUATOR - An apparatus for automation technology, comprising an actuator and an assembly for manual actuation of the actuator, wherein an electrical drive or an electro hydraulic drive is provided as the driving element for the actuator. The assembly includes a generator and a manual actuating element for the generator and wherein the assembly can be electrically coupled with the driving element of the actuator. | 05-08-2014 |