Patent application number | Description | Published |
20130277548 | Method Of Mass Spectrometry And A Mass Spectrometer - The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas. | 10-24-2013 |
20140191123 | Ion Guide Coupled to MALDI Ion Source - A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other. | 07-10-2014 |
20140291501 | Photo-Dissociation of Proteins and Peptides in a Mass Spectrometer - A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser. | 10-02-2014 |
20140361162 | IMAGING MASS SPECTROMETER AND A METHOD OF MASS SPECTROMETRY - An imaging mass spectrometer comprising an energy source adapted to substantially simultaneously provide energy to multiple spots on a sample to produce ions from the sample by a desorption process; and an analyser adapted to detect the arrival time and spot origin of ions resulting from said desorption process. | 12-11-2014 |
20150034814 | MALDI Imaging and Ion Source - An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ≦300 mm. The laser beam is directed onto the target substrate at an angle θ with respect to the perpendicular to the target substrate, wherein θ≦3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror. | 02-05-2015 |
20160027625 | Automated Tuning for MALDI Ion Imaging - A method of ion imaging is disclosed comprising testing a first portion of a sample by automatically varying one or more parameters of a laser or other ionisation device and manually or automatically determining from the first portion one or more optimum or preferred parameters of the laser or other ionisation device. A second portion of the sample is then analysed using the one or more optimum or preferred parameters. | 01-28-2016 |
20160027626 | Data Directed Storage of Imaging Mass Spectra - A method of ion imaging is disclosed comprising scanning a sample and acquiring first mass spectral data related to a first pixel location at a first spatial resolution and determining whether or not the first mass spectral data satisfies a condition. If it is determined that the first mass spectral data does satisfy the condition then the first mass spectral data is stored, recorded or prioritized. If it is determined that the first mass spectral data does not satisfy the condition then the first mass spectral data is discarded or downgraded. Scanning of the sample then continues at the first spatial resolution and further mass spectral data related to further pixel locations is acquired. | 01-28-2016 |
20160049282 | Data Directed Acquisition of Imaging Mass - A method of ion imaging is disclosed comprising scanning a sample at a first resolution and acquiring first mass spectral data related to a first pixel location. A determination is then made as to whether or not the first mass spectral data satisfies a condition, wherein if it is determined that the first mass spectral data does satisfy the condition then the method further comprises: (i) switching to acquire second mass spectral data related to a second pixel location which is substantially adjacent to the first pixel location so that the second mass spectral data is acquired at a second resolution which is higher than the first resolution; and (ii) determining whether or not the second mass spectral data satisfies the condition, wherein if it is determined that the second mass spectral data does satisfy the condition then the method further comprises acquiring third mass spectral data related to a third pixel location which is substantially adjacent to the first or second pixel locations so that the third mass spectral is acquired at the second resolution and wherein if it is determined that the second or third mass spectral data does not satisfy the condition then the method further comprises switching back to scanning the sample at the first resolution. | 02-18-2016 |
20160071716 | MALDI IMAGING AND ION SOURCE - An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length≦300 mm. The laser beam is directed onto the target substrate at an angle θ with respect to the perpendicular to the target substrate, wherein θ≦3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror. | 03-10-2016 |