Patent application number | Description | Published |
20080214548 | 2-Cyano-Pyrimidines and-Triazines as Cysteine Protease Inhibitors - The invention relates to compounds of the formula I | 09-04-2008 |
20080234284 | Pyrazolo[1,5-a]Pyrimidin-7-Yl Amine Derivatives as Protein Kinase Inhibitors - The invention relates to pyrazolo[1,5a]pyrimidin-7-yl amine derivatives of formula (I) | 09-25-2008 |
20080261973 | Sulphonamidoaniline Derivatives Being Janus Kinase Inhibitors - The invention relates to sulphonamidoanilines of formula I, | 10-23-2008 |
20080262021 | 1H-Imidazoquinoline Derivatives as Prote In Kinase Inhibitors - The invention relates to imidazoquinolines of formula (I) for use in the treatment of protein kinase dependent diseases; pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease; novel imidazoquinolines; and a process for the preparation of the novel imidazoquinolines. | 10-23-2008 |
20080275054 | 3-(Substituted Amino)-Pyrazolo[3, 4-D]Pyrimidines as Ephb and Vegfr2 Kinase Inhibitors - The invention relates to novel pyrazolo[3,4-d]pyrimidines of the formula | 11-06-2008 |
20080287427 | Bicyclic Amides as Kinase Inhibitors - The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising en a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases. | 11-20-2008 |
20080300245 | Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acids as Ephb and Vegfr2 Kinase Inhibitors - The invention relates to novel pyrazolo[1,5a]pyridine-3-carboxylic acid compounds of the formula | 12-04-2008 |
20080312248 | Pyrimidinyl Aryl Urea Derivatives Being Fgf Inhibitors - The invention relates to heteroaryl aryl ureas of the formula IA, | 12-18-2008 |
20080319005 | Phenylacetamides Suitable as Protein Kinase Inhibitors - The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases. | 12-25-2008 |
20090012094 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS - Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors. | 01-08-2009 |
20090039811 | Inhibitors of HSP90 - The invention relates to the use of 1H-indazol-6-ol compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising 1H-indazol-6-ol compounds, novel 1H-indazol-6-ol compounds, and a process for the preparation of the novel 1H-indazol-6-ol compounds. | 02-12-2009 |
20090069341 | INHIBITORS OF HSP90 - The invention relates to the use of benzoimidazolone compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising benzoimidazolone compounds, novel benzoimidazolone compounds, and a process for the preparation of the novel benzoimidazolone compounds. | 03-12-2009 |
20090099167 | Organic compounds - The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds. | 04-16-2009 |
20090118277 | 3 Unsubstituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors - The invention relates to 3-unsubstituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidine compounds, their use as kinase inhibitors, new pharmaceutical formulations comprising said compounds, said compounds for use in the diagnostic or therapeutic treatment of warm-blooded animals, especially humans, their use in the treatment of diseases or for the manufacture of pharmaceutical formulations useful in the treatment of diseases that respond to modulation of kinase, especially tie-2 kinase, activity, methods of treatment comprising administration of said compounds to a warm-blooded animal, especially a human, and processes for the manufacture of said compounds. | 05-07-2009 |
20090131437 | DISUBSTITUTED UREAS AS KINASE INHIBITORS - The invention relates to compounds of the formula (I), their use as kinase inhibitors, new pharmaceutical formulations comprising said compounds, said compounds for use in the diagnostic or therapeutic treatment of warm-blooded animals, especially humans, their use in the treatment of diseases or for the manufacture of pharmaceutical formulations useful in the treatment of diseases that respond to modulation of kinase activity, methods of treatment comprising administration of said compounds to a warm-blooded animal, especially a human, and processes for the manufacture of said compounds. | 05-21-2009 |
20090137804 | Compounds and Compositions as Protein Kinase Inhibitors - The invention relates to compounds of formula (I) | 05-28-2009 |
20090258882 | 2,4-Substituted Quinazolines as Lipid Kinase Inhibitors - The invention relates to compounds of the formula I, | 10-15-2009 |
20090264649 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS - Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors. | 10-22-2009 |
20090275593 | 3 Substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors - The invention relates to 3-substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidine compounds, their use as kinase inhibitors, new pharmaceutical formulations comprising said compounds, said compounds for use in the diagnostic or therapeutic treatment of warm-blooded animals, especially humans, their use in the treatment of diseases or for the manufacture of pharmaceutical formulations useful in the treatment of diseases that respond to modulation of kinase, especially tie-2 kinase, activity, methods of treatment comprising administration of said compounds to a warm-blooded animal, especially a human, and processes for the manufacture of said compounds. | 11-05-2009 |
20090286821 | INHIBITORS OF TYROSINE KINASES - The invention relates to compounds of formula | 11-19-2009 |
20090318410 | IMIDAZOPYRIDAZINES AS LIPID KINASE INHIBITORS - The invention relates to novel compounds of the formula I, | 12-24-2009 |
20100029636 | Lck inhibitors - The invention relates to novel pyrazolo[1,5-A]pyrimidine compounds of Formula I | 02-04-2010 |
20100041662 | Heterocyclic compounds as antiinflammatory agents - A compound of Formula Ia or Ib in free or salt or solvate form, where R | 02-18-2010 |
20100056558 | 1,3-DIHYDRO-IMIDAZO[4,5-C]QUINOLIN-2-ONES AS LIPID KINASE INHIBITORS - The invention relates to novel organic compounds of formula (I) | 03-04-2010 |
20100069395 | Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid compounds as protein kinase inhibitors - Compounds of formula | 03-18-2010 |
20100075980 | Phenylacetamides being FLT3 Inhibitors - Compounds of formula | 03-25-2010 |
20100093821 | 3-Amino-pyrazole-4-carboxamide derivatives useful as inhibitors of protein kinases - The invention relates to novel heterocyclic compounds of the formula | 04-15-2010 |
20100105711 | Organic Compounds - The present invention relates to a compound of formula (I) | 04-29-2010 |
20110003818 | Substituted 2-Carboxamide Cycloamino Ureas - The present invention relates to compounds of formula I | 01-06-2011 |
20110039831 | 3-HETEROARYLMETHYL-IMIDAZO[1,2-B]PYRIDAZIN-6-YL DERIVATIVES - The invention relates to compounds of formula (I) and salts thereof | 02-17-2011 |
20110218187 | INHIBITORS OF TYROSINE KINASES - The invention relates to compounds of formula | 09-08-2011 |
20110251202 | 1,3-Dihydro-imidazo[4,5-c]quinolin-2-ones as Lipid Kinase Inhibitors - The invention relates to novel organic compounds of formula (I) | 10-13-2011 |
20110301157 | BICYCLIC AMIDES AS KINASE INHIBITORS - The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases. | 12-08-2011 |
20120149661 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS - The invention relates to tetra-substituted heteroarylic compounds of the formula (I) | 06-14-2012 |
20120165310 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS - The invention relates to compounds of formula I, | 06-28-2012 |
20120184561 | PHENYLACETAMIDES SUITABLE AS PROTEIN KINASE INHIBITORS - The invention relates to compounds of the formula I, | 07-19-2012 |
20120207751 | Imidazoquinolines as lipid kinase inhibitors - The invention relates to a combination comprising compounds of formula (I) | 08-16-2012 |
20120263712 | PYRROLIDINE-1,2-DICARBOXAMIDE DERIVATIVES - The present invention relates to a compound of formula (I) | 10-18-2012 |
20120289501 | Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls - The invention relates to new derivatives of formula I, wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a proliferative disease. | 11-15-2012 |
20120309741 | QUINOXALINE CARBOXAMIDE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS - The invention relates to compounds of formula (I) | 12-06-2012 |
20120309766 | QUINOXALINE CARBOXAMIDE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS - The invention relates to compounds of formula (I) | 12-06-2012 |
20130012476 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention relates to compounds of formula (I) | 01-10-2013 |
20130012704 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention relates to compounds of formula (I) | 01-10-2013 |
20130030171 | Pyrimidinyl Aryl Urea Derivatives being FGF Inhibitors - The invention relates to heteroaryl aryl ureas of the formula IA, | 01-31-2013 |
20130085161 | PIPERIDINYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES - The invention relates to new derivatives of formula (I), | 04-04-2013 |
20130090342 | BIPHENYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES - The invention relates to new derivatives of formula (I), | 04-11-2013 |
20130165436 | Dihydro-Benzo-Oxazine and Dihydro-Pyrido-Oxazine Derivatives - The invention relates to dihydro-benzo-oxazine and dihydro-pyrido-oxazine compounds of the formula (I) and/or pharmaceutically acceptable salts and/or solvates thereof, | 06-27-2013 |
20130225574 | OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF - The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K. | 08-29-2013 |
20130237519 | BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION - Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. | 09-12-2013 |
20130281473 | SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES - The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) | 10-24-2013 |
20130310395 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 - The present invention relates to compounds of formula (I): | 11-21-2013 |
20130317024 | PYRROLOPYRROLIDINONE COMPOUNDS - The invention relates to compounds of formula (I): | 11-28-2013 |
20130324519 | QUINOXALINE CARBOXAMIDE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS - The invention relates to compounds of formula (I) | 12-05-2013 |
20140005163 | 1H-IMIDAZO[4,5-C]QUINOLINONE DERIVATIVES | 01-02-2014 |
20140005232 | PYRROLIDINE-1,2-DICARBOXAMIDE DERIVATIVES | 01-02-2014 |
20140135306 | HDYROXY SUBSTITUTED ISOQUINOLINONE DERIVATIVES - The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof. | 05-15-2014 |
20140135330 | Oxazolidin-2-one-Pyrimidine Derivatives - The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K. | 05-15-2014 |
20140186469 | PYRROLIDINE-1,2-DICARBOXAMIDE DERIVATIVES - The present invention relates to a compound of formula (I) | 07-03-2014 |
20140249139 | Quinazoline Derivatives - The invention relates to substituted quinazoline derivative of the formula (I), wherein A, X | 09-04-2014 |
20140249177 | SALT FORMS OF BICYCLIC HETEROCYCLIC DERIVATIVES - The present invention provides novel solid forms of pharmaceutically active agents and therapeutic uses thereof. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition. | 09-04-2014 |
20140275158 | CYCLOHEXYL ISOQUINOLINONE COMPOUNDS - The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof. | 09-18-2014 |
20140336166 | NOVEL PURINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE - The invention relates to PI3K inhibitors of the formula (I) • in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenerative disorders, and to medicaments comprising them. | 11-13-2014 |
20140343084 | IMIDAZOPYRROLIDINONE COMPOUNDS - The invention relates to compounds of formula (I): | 11-20-2014 |
20140343086 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 - The present invention relates to compounds of formula (I): | 11-20-2014 |
20140350010 | Pyrazolopyrrolidine Compounds - The invention relates to compounds of formula (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds. | 11-27-2014 |
20140378450 | OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF - The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K. | 12-25-2014 |
20150025059 | BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION - Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. | 01-22-2015 |