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| 20120279298 | CONDUCTIVE PATTERNS AND METHODS FOR MAKING CONDUCTIVE PATTERNS - This document provides conductive patterns, electrical sensors including conductive patterns, and methods of making conductive patterns used in electrical sensors. In some cases, the conductive patterns can define one or more microelectrodes. For example, thermal transfer printing techniques are described. In some cases, a microfluidics device can include one or more microelectrodes in a micro-channel. | 11-08-2012 |
| 20130295588 | COUNTING PARTICLES USING AN ELECTRICAL DIFFERENTIAL COUNTER - This disclosure relates to methods and devices to count particles of interest, such as cells. The methods include obtaining a fluid sample that may contain particles of interest; counting all types of particles in a portion of the sample using a first electrical differential counter to generate a first total; removing any particles of interest from the portion of the fluid sample; counting any particles remaining in the portion of the fluid sample using a second electrical differential counter after the particles of interest are removed to generate a second total; and calculating a number of particles of interest originally in the fluid sample by subtracting the second total from the first total, wherein the difference is the number of particles of interest in the sample. These methods and related devices can be used, for example, to produce a robust, inexpensive diagnostic kit for CD4+ T cell counting in whole blood samples. | 11-07-2013 |
| 20150056717 | Microfluidic Metering of Fluids - This document provides methods and devices for metering fluids. In some cases, the methods and devices include intersecting channels that include capillary-stop geometries at each intersection point that guides the fluids on a desired path, which is controlled by the opening and closing of valves. For example, a metering channel can intersect a loading channel and intersect an outflow channel and a metering portion can be defined by the geometry of the metering channel between the intersection points. | 02-26-2015 |
| 20150190802 | FLUID DELIVERY DEVICES, SYSTEMS, AND METHODS - This document provides devices, systems, and methods for delivering fluids. In some cases, the devices, systems, and methods include a deformable reservoir being at least partially defined by rigid plastically-deformable web. An actuator can press against said rigid plastically-deformable web to plastically deform said web. In some cases, a controller is adapted to receive a cartridge including a deformable reservoir and control the pressing of an actuator against a rigid plastically-deformable web to deliver fluid from the deformable reservoir. | 07-09-2015 |
| 20150190805 | FLUID DELIVERY DEVICES, SYSTEMS, AND METHODS - This document provides devices, systems, and methods for delivering fluids. In some cases, the devices, systems, and methods include a reservoir including a sealed flexible material defining a cavity and a housing around the sealed flexible material. The cavity can contain a fluid to be delivered. The sealed flexible material includes at least one breakable seal. The housing includes a rigid side wall supporting said sealed flexible material. In some cases, methods provided herein can deliver fluid by pressing against a top surface of said sealed flexible material. In some cases, systems provided herein can include a controller adapted to receive said cartridge and press a top surface of said sealed flexible material to pressurize said fluid in said cavity to a pressure sufficient to deliver fluid past said breakable seal. | 07-09-2015 |
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| 20090311387 | HYDRATED FAT PIECE COMPOSITIONS AND DOUGH ARTICLES MADE THEREFROM - Disclosed are hydrated fat piece compositions along with various methods of making hydrated fat piece compositions. Also disclosed are dough compositions and baked articles made using the hydrated fat piece compositions of the invention. | 12-17-2009 |
| 20110008490 | DOUGH COMPOSITIONS HAVING A MOISTURE BARRIER, AND RELATED METHODS - Described are dough products that contain a hydrogel coating, wherein the hydrogel coating contains a hydrophilic colloid, oil, plasticizer, and water, and functions as a moisture barrier. | 01-13-2011 |
| 20110183046 | COATED FOOD PRODUCT AND METHOD OF PREPARATION - Coated snack products are provided whose coating are reminiscent of high fat compound fat coating, resistant to rub-off of a powdery or fat based topping as well as methods for preparing such coated snack products. The present invention provides methods for preparing such coated food product including providing a hot (about 60-85° C.), oil-in-water emulsion coating slurry containing a hydrated film forming hydrophilic colloid. The slurry comprises about 5%-30% of the emulsion of flavor solids in powder form. The methods include applying the hot emulsion to a food base to provide a wet emulsion coated food base. The methods include drying the wet slurry emulsion coated food product to a moisture content of about 1-4% at a temperature of less than the sugar melting point to provide a finished dried food product having non-powdered coating. | 07-28-2011 |
| 20120064193 | SHORTENING PARTICLE COMPOSITIONS AND PRODUCTS MADE THEREFROM - The invention relates to shortening particle compositions that are suitable for use in preparing batter or dough products such as biscuits, pizza crusts, pot pie crusts, cinnamon rolls, or dry mixes for same. Typically, the shortening compositions are low in trans fatty acids and in saturated fatty acids. For example, the shortening particle composition may comprise less than about 3% wt. total trans fatty acids and a total of about less than about 61% wt. saturated fatty acids and trans fatty acids. | 03-15-2012 |
| 20120064195 | SHORTENING PARTICLE COMPOSITIONS AND DOUGH PRODUCTS MADE THEREFROM - The invention relates to shortening particle compositions that are suitable for use in preparing baked goods such as biscuits, pizza crusts, pot pie crusts, and cinnamon rolls. Typically, the shortening compositions are low in trans fatty acids and in saturated fatty acids. For example, the shortening particle composition may comprise less than about 3% wt. total trans fatty acids and a total of about less than about 61% wt. saturated fatty acids and trans fatty acids. | 03-15-2012 |
| 20120308683 | DOUGH COMPOSITIONS AND RELATED METHODS INVOLVING HIGH-GLUTEN CONTENT - Described are dough compositions and related methods that involve the use of a preferment or sponge dough, and wherein the preferment or sponge dough composition includes a concentrated protein ingredient, optionally to produce an unproofed dough composition that can be baked without proofing. | 12-06-2012 |
| 20120308708 | Fat Compositions and Related Methods, Including Shortening Particles and Shortening Compositions without Added Non-Interestified Hardstock Fat, and Related Products - Described are fat compositions (e.g., shortening composition and shortening particles) that are suitable for use in preparing batter or dough products such as biscuits, pizza crusts, pot pie crusts, cinnamon rolls, or dry mixes for same; the fat compositions can be low in trans fatty acids with moderate levels of saturated fatty acids. For example, fat compositions may comprise less than about 2% wt. total trans fatty acids and a total of less than about 70% wt. saturated fatty acids and trans fatty acids. | 12-06-2012 |
| 20130337145 | SHORTENING PARTICLE COMPOSITIONS AND DOUGH PRODUCTS MADE THEREFROM - The invention relates to shortening particle compositions that are suitable for use in preparing baked goods such as biscuits, pizza crusts, pot pie crusts, and cinnamon rolls. Typically, the shortening compositions are low in trans fatty acids and in saturated fatty acids. For example, the shortening particle composition may comprise less than about 3% wt. total trans fatty acids and a total of about less than about 61% wt. saturated fatty acids and trans fatty acids. | 12-19-2013 |
| 20140037793 | SHORTENING PARTICLE COMPOSITIONS AND DOUGH PRODUCTS MADE THEREFROM - The invention relates to shortening particle compositions that are suitable for use in preparing batter or dough products such as biscuits, pizza crusts, pot pie crusts, cinnamon rolls, or dry mixes for same. Typically, the shortening compositions are low in trans fatty acids and in saturated fatty acids. For example, the shortening particle composition may comprise less than about 3% wt. total trans fatty acids and a total of about less than about 61% wt. saturated fatty acids and trans fatty acids. | 02-06-2014 |
| 20140205720 | Coated Food Product and Method of Preparation - Coated snack products are provided whose coating are reminiscent of high fat compound fat coating, resistant to rub-off of a powdery or fat based topping as well as methods for preparing such coated snack products. The present invention provides methods for preparing such coated food product including providing a hot (about 60-85° C.), oil-in-water emulsion coating slurry containing a hydrated film forming hydrophilic colloid. The slurry comprises about 5%-30% of the emulsion of flavor solids in powder form. The methods include applying the hot emulsion to a food base to provide a wet emulsion coated food base. The methods include drying the wet slurry emulsion coated food product to a moisture content of about 1-4% at a temperature of less than the sugar melting point to provide a finished dried food product having non-powdered coating. | 07-24-2014 |
| 20150050412 | FAT PARTICLE COMPOSITIONS CONTAINING SALT, DOUGH AND BAKED DOUGH ARTICLES MADE THEREFROM, AND RELATED METHODS - Fat particles useful in food compositions as doughs, methods of preparing the fat particles, method of preparing the food compositions (e.g., doughs) that contain the fat particles, and methods of preparing a baked food product from the food composition, wherein the fat particles contain flavorant salt. These fat particle can be used to prepare dough formulations that meet the desire of being more healthful than previous dough formulations due to a reduced sodium content, optional more healthful fat content (e.g., low trans fats or low saturated fats), or both. Additionally, the fat particles can be conveniently used in commercial or consumer scale dough processing. | 02-19-2015 |
| 20150216197 | SHORTENING PARTICLE COMPOSITIONS AND DOUGH PRODUCTS MADE THEREFROM - The invention relates to shortening particle compositions that are suitable for use in preparing batter or dough products such as biscuits, pizza crusts, pot pie crusts, cinnamon rolls, or dry mixes for same. Typically, the shortening compositions are low in trans fatty acids and in saturated fatty acids. For example, the shortening particle composition may comprise less than about 3% wt. total trans fatty acids and a total of about less than about 61% wt. saturated fatty acids and trans fatty acids. | 08-06-2015 |
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| 20080212219 | Astrometry and photometry with coronagraphs - In a first exemplary embodiment of the present invention, an optical device comprises a telescope, a coronagraph device coupled to the telescope and having a focal plane occulting mask to provide a coronagraphic image, and a reticulate grid element arranged in a light path propagated through the telescope, at a location relative to the coronagraphic image, to create controlled fiducial spots in the coronagraphic image. | 09-04-2008 |
| 20080259447 | Spectroscopy of exoplanets from a ground-based telescope - In a first exemplary embodiment of the present invention, an optical device comprises a telescope and a pipescope arranged as a spatial filter to light propagated through the telescope, to confine a field of view to θ | 10-23-2008 |
| 20100290111 | ASTROMETRY AND PHOTOMETRY WITH CORONAGRAPHS - In a first exemplary embodiment of the present invention, an optical device comprises a telescope, a coronagraph device coupled to the telescope and having a focal plane occulting mask to provide a coronagraphic image, and a reticulate grid element arranged in a light path propagated through the telescope, at a location relative to the coronagraphic image, to create controlled fiducial spots in the coronagraphic image. | 11-18-2010 |
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| 20090018136 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF VASCULAR DISEASE - The present invention is directed to a novel methods and compositions for the therapeutic intervention of vascular complications associated with diabetes, hyperlipidemias, and various cardiovascular disorders including but not limited to recalcitrant hypertension, coronary artery disease, pulmonary arterial hypertension, congestive heart failure, and hemolytic anemias. More specifically, the specification describes methods and compositions for treating such vascular disorders using compositions comprising BH4 and derivative thereof. Combination therapies of BH4 and other therapeutic regimens are contemplated. | 01-15-2009 |
| 20090076014 | Methods of Administering Tetrahydrobiopterin, Associated Compositions, And Methods of Measuring - The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample. | 03-19-2009 |
| 20100009996 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF METABOLIC DISORDERS - The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated. | 01-14-2010 |
| 20100009997 | METHOD OF TREATING A METABOLIC OR NEUROPSYCHIARTY DISORDER WITH A BH4 DERIVATIVE PRODRUG - Low dose therapeutic methods for use of BH4 derivatives to treat BH4-responsive disorders, such as hyperphenylalanemia and neuropsychiatric diseases, and combination therapies of BH4 derivatives and other therapeutic regimens, are described. | 01-14-2010 |
| 20100111918 | METHODS OF ADMINISTERING TETRAHYDROBIOPTERIN, ASSOCIATED COMPOSITIONS, AND METHODS OF MEASURING - The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample. | 05-06-2010 |
| 20110281880 | METHODS OF ADMINISTERING TETRAHYDROBIOPTERIN, ASSOCIATED COMPOSITIONS, AND METHODS OF MEASURING - The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample. | 11-17-2011 |
| 20120108599 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF METABOLIC DISORDERS - The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and compositions for treating various types of phenylketonurias using compositions comprising BH4. Combination therapies of BH4 and other therapeutic regimens are contemplated. | 05-03-2012 |
| 20130237543 | METHODS OF ADMINISTERING TETRAHYDROBIOPTERIN, ASSOCIATED COMPOSITIONS, AND METHODS OF MEASURING - The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample. | 09-12-2013 |
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| 20130086459 | Automatic Scoping of Data Entities - A system for creating a report in a spreadsheet includes a data source module programmed to identify sources of data items associated with the spreadsheet, an active module programmed to identify which of the data items are associated with the report that is generated in the spreadsheet, and a display module programmed to display on a field pane with an active tab and an all tab, the active tab displaying those data items that are determined to be associated with the report that is being generated in the spreadsheet, and the all tab displaying all of the data items associated with the spreadsheet. | 04-04-2013 |
| 20130086460 | Automatic Relationship Detection for Reporting on Spreadsheet Data - A system for creating a report in a spreadsheet includes: a central processing unit; and a memory encoding instructions that, when executed by the central processing unit, cause the central processing unit to create: a data source module programmed to identify tables associated with the spreadsheet; a relationship module programmed to analyze the tables and identify relationships between the items; and a display module programmed to display the relationships between the tables. | 04-04-2013 |
| 20130124957 | STRUCTURED MODELING OF DATA IN A SPREADSHEET - Data displayed on a spreadsheet and data from one or more data sources are used to create a model within the spreadsheet. The data may be obtained from many types of data sources, such as: relational databases, multidimensional sources, cloud services, data feeds, spreadsheet files, text files, data from the Web, and the like. A modeling engine of the spreadsheet application creates the model that structures the data, relates different pieces of data, and provides context for the data. The model that may be stored within the spreadsheet includes the raw data and metadata that describes the data and provides the context for the data. The model may be automatically updated based on performed operations of the spreadsheet. The model may be examined using a query language (e.g. MDX, DAX, SQL, Spreadsheet Functions and Formulas, . . . ) to examine the data and the relationships obtained from the spreadsheet and data sources. | 05-16-2013 |
| 20130124960 | AUTOMATED SUGGESTED SUMMARIZATIONS OF DATA - Technologies are described herein for generating field sets of a data summary table. Multiple fields in a spreadsheet document are identified. Multiple field scores for each field of the plurality of fields are determined. A field set incorporating two or more of the plurality of fields is generated based on the plurality of field scores. The field set is inserted into the data summary table, thereby transforming the data summary table without the field set to the data summary table with the field set. | 05-16-2013 |
| 20150193423 | AUTOMATIC RELATIONSHIP DETECTION FOR SPREADSHEET DATA ITEMS - A system for automatically detecting relationships in spreadsheet data is disclosed. The system may be configured to analyze data items in the spreadsheet to determine whether two or more data items are unrelated. If the two or more data items are unrelated, then the system may notify a user of a need to define the relationship, and automatically defines the relationship for the two or more data items, or suggests the relationship to the user. | 07-09-2015 |
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| 20080257134 | Method And Apparatus For Generating And Updating A Pre-Categorized Song Database From Which Consumers May Select And Then Download Desired Playlists - Apparatus, methods, systems, and data structures for organizing music files such that consumers can download single songs or entire predetermined libraries of songs with one or two clicks on an Internet browser. For passive listeners without the time to generate their own playlists, 500 to 30,000 song libraries can be downloaded to a PC, and then side loaded to an MP3 player. This will enable users to replicate the experience of listening to a favorite broadcast radio channel having songs most likely to please the listener, with zero interruptions. The stored and downloaded songs are individually categorized by song title, artist, mood/tempo, multiple genres, era, original song release date, and audience reach (e.g., audience crossover potential). For a subscription fee, the consumer will have continued access to listen to the downloaded and side loaded songs, but without the ability to copy or transfer the song. For an additional fee (or a higher subscription fee) the consumer can take actual ownership of downloaded song libraries and/or individual songs. | 10-23-2008 |
| 20090071316 | APPARATUS FOR CONTROLLING MUSIC STORAGE - Apparatus for controlling music storage includes a memory, and a processor configured to (i) control the storing of a plurality of digital song files in the memory, and (ii) control the storing in the memory of a plurality of song indicia corresponding to each digital song file. The plurality of song indicia for each digital song file preferably includes artist, song title, and at least one of (i) audience reach, (ii) song original release date, (iii) plural different genres, (iv) mood, and (v) era. The apparatus may comprise on or more of a portable music player, a personal computer, an Internet server, or a cable or satellite device. | 03-19-2009 |
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| 20090182168 | PROCESS FOR THE SELECTIVE DEPROTONATION AND FUNCTIONALIZATION OF 1-FLUORO-2-SUBSTITUTED-3-CHLOROBENZENES - 1-Fluoro-2-substituted-3-chlorobenzenes are selectively deprotonated and functionalized in the position adjacent to the fluoro substituent. | 07-16-2009 |
| 20130030213 | METHODS OF ISOLATING 4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYLBORONIC ACIDS - Provided herein are methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronic acid. The method comprises contacting a mixture of water, a water miscible organic solvent, and a 4-chloro-2-fluoro-3-substituted-phenylboronic acid with a salt to form a water miscible organic solvent layer and a water layer. The 4-chloro-2-fluoro-3-substituted-phenylboronic acid is partitioned into the water miscible organic solvent layer, which is separated from the water layer. Additional methods are disclosed, as is a 4-chloro-2-fluoro-3-substituted-phenylboronic acid produced by one of the methods, wherein the 4-chloro-2-fluoro-3-substituted-phenylboronic acid is obtained at a yield of greater than approximately 90%. | 01-31-2013 |
| 20130172566 | METHODS OF PRODUCING METHYL 4-AMINO-3-CHLORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL)PYRIDINE-2-CARBOXYL- ATE - Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate. One method comprises adding methyl isobutyl ketone to an aqueous solution comprising 4-chloro-2-fluoro-3-methoxyphenyl-boronic acid to form an organic phase comprising the 4-chloro-2-fluoro-3-methoxyphenylboronic acid and an aqueous phase. The organic phase and the aqueous phase are separated. The 4-chloro-2-fluoro-3-methoxyphenylboronic acid is reacted with methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate in methyl isobutyl ketone to produce methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate, which is deacetylated to produce methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate. | 07-04-2013 |
| 20130172567 | METHODS OF ISOLATING (4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYL)BORONATES AND METHODS OF USING THE SAME - Methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate include adding carbon dioxide gas or carbon dioxide solid (dry ice) to a solution comprising a 4-chloro-2-fluoro-3-substituted-phenylboronate, an inert organic solvent, and at least one lithium salt to react the at least one lithium salt with the carbon dioxide gas or carbon dioxide solid (dry ice) and form a mixture comprising the 4-chloro-2-fluoro-3-substituted-phenylboronate, the inert organic solvent, and a precipitated solid. The precipitated solid may be removed from the mixture. Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronates to produce methyl-4-amino-3-chloro-6-(4-chloro-2-fluoro-3-substituted-phenyl)pyridine-2-carboxylates are also disclosed. A 4-chloro-2-fluoro-3-substituted-phenylboronate produced by one of the methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate is also disclosed, wherein the 4-chloro-2-fluoro-3-substituted-phenylboronate may be obtained at a yield of greater than or equal to about 90%. | 07-04-2013 |
| 20140170058 | PROCESS FOR THE REMOVAL OF PALLADIUM FROM 4-AMINO-3-HALO-5-FLUORO-6-(ARYL) PYRIDINE-2-CARBOXYLATES AND 4-AMINO-3-HALO-6-(ARYL)PYRIDINE-2-CARBOXYLATES - Residual palladium is removed and recovered from 4-amino-3-halo-5-fluoro-6-(aryl)pyridine-2-carboxylates and 4-amino-3-halo-6-(aryl)pyridine-2-carboxylates by treatment with an aqueous solution containing from about 20 to about 50% of an alkali metal bisulfite at a temperature from about 60 to about 90° C. and a pH from about 3.8 to about 7.0. | 06-19-2014 |
| 20150065743 | METHODS FOR PRODUCING BORYLATED ARENES - Methods for the selective borylation of arenes, including arenes substituted with an electron-withdrawing group (e.g., 1-chloro-3-fluoro-2-substituted benzenes) are provided. The methods can be used, in some embodiments, to efficiently and regioselectively prepare borylated arenes without the need for expensive cryogenic reaction conditions. | 03-05-2015 |
| 20150203514 | METHODS OF FORMING 4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYLBORONIC ACID PINACOL ESTERS AND METHODS OF USING THE SAME - Methods include formation of 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. The method comprises contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene. The lithiated 1-chloro-3-fluoro-2-substituted benzene is contacted with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate. The 4-chloro-2-fluoro-3-substituted-phenylboronate is reacted with an aqueous base to form a (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate. The (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate is reacted with an acid to form a 4 chloro-2-fluoro-3-substituted-phenylboronic acid. The 4-chloro-2-fluoro-3-substituted-phenylboronic acid is reacted with 2,3-dimethyl-2,3-butanediol to form 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters . Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters to produce 6-(4-chloro-2-fluoro-3-substituted-phenyl)-4-aminopicolinates are also disclosed. | 07-23-2015 |
| 20150239843 | METHODS OF ISOLATING (4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYL)BORONATES AND METHODS OF USING THE SAME - Methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate include adding carbon dioxide gas or carbon dioxide solid (dry ice) to a solution comprising a 4-chloro-2-fluoro-3-substituted-phenylboronate, an inert organic solvent, and at least one lithium salt to react the at least one lithium salt with the carbon dioxide gas or carbon dioxide solid (dry ice) and form a mixture comprising the 4-chloro-2-fluoro-3-substituted-phenylboronate, the inert organic solvent, and a precipitated solid. The precipitated solid may be removed from the mixture. Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronates to produce methyl-4-amino-3-chloro-6-(4-chloro-2-fluoro-3-substituted-phenyl)pyridine-2-carboxylates are also disclosed. A 4-chloro-2-fluoro-3-substituted-phenylboronate produced by one of the methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate is also disclosed, wherein the 4-chloro-2-fluoro-3-substituted-phenylboronate may be obtained at a yield of greater than or equal to about 90%. | 08-27-2015 |
