Patent application number | Description | Published |
20090208134 | Image Processing and Analysis Framework - A system and method for processing and analyzing virtual microscopy digital images (“digital slides”) is provided. The system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slides. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. The digital slide can be accessed locally or remotely across a network. Similarly, the image processing routines can be obtained from local storage or across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely obtained routines. Access to image processing and analysis may be restricted through a monitor process that authenticates requests to process or view digital slides. Variations in restrictions to images provide a rich diversity in access levels that allow sharing of digital slides and demonstrations of image processing algorithms. | 08-20-2009 |
20090303321 | System and Computer Readable Medium for Pre-focus of Digital Slides - Methods and apparatus are provided for computing focus information prior to scanning digital microscope slides with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation. | 12-10-2009 |
20100027856 | Method for Pre-focus of Digital Slides - Methods and apparatus are provided for computing focus information prior to scanning digital microscope slides with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation. | 02-04-2010 |
20100141753 | Optimizing Virtual Slide Image Quality - Systems and methods for assessing and optimizing virtual microscope slide image quality are provided. In order to determine whether a virtual slide image has any out of focus areas and is therefore a candidate for manual inspection, the various focus points used to scan the virtual slide image are used to calculate a best fit surface for the virtual slide image. The distance of each focus point from the best fit surface is then calculated and the largest distance is compared to a predetermined value. If the largest distance from a focus point to the best fit surface is larger than the predetermined value, then the virtual slide image is designated as needing a manual inspection and possible re-scan. | 06-10-2010 |
20110141263 | Achieving Focus in a Digital Pathology System - Methods and apparatus are provided for computing focus information prior to scanning digital microscope slide data with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation. | 06-16-2011 |
20120014576 | Signal to Noise Ratio in Digital Pathology Image Analysis - A digital slide analysis system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slide images. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. Prior to the application of selected routine, the system employs a digital pre-processing module to create a metadata mask that reduces undesirable image data such that the image data processed by the selected routine has an improved signal to noise ratio. The pre-processing module uses a classifier that may be implemented as a pattern recognition module, for example. Undesirable image data is therefore excluded from the image data that is processed by the digital pathology image processing and analysis routine, which significantly improves the digital pathology image analysis. | 01-19-2012 |
20120114204 | Optimizing Virtual Slide Image Quality - Systems and methods for assessing and optimizing virtual microscope slide image quality are provided. In order to determine whether any of multiple virtual slide images has an out of focus area and is therefore a candidate for manual inspection or rescanning, various focus points used to scan each virtual slide image are used to calculate a best fit surface for each virtual slide image. The best fit surface is then used to determine whether any of the various focus points are outliers. If it is determined that a virtual slide image is associated with outlying focus points, it is identified as a candidate for manual inspection or rescanning. | 05-10-2012 |
20120269409 | SIGNAL TO NOISE RATIO IN DIGITAL PATHOLOGY IMAGE ANALYSIS - A digital slide analysis system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slide images. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. Prior to the application of selected routine, the system employs a digital pre-processing module to create a metadata mask that reduces undesirable image data such that the image data processed by the selected routine has an improved signal to noise ratio. The pre-processing module uses a classifier that may be implemented as a pattern recognition module, for example. Undesirable image data is therefore excluded from the image data that is processed by the digital pathology image processing and analysis routine, which significantly improves the digital pathology image analysis. | 10-25-2012 |
20120281931 | Image Processing and Analysis Framework - A system and method for processing and analyzing virtual microscopy digital images (“digital slides”) is provided. The system comprises an algorithm server that accesses a plurality of image processing and analysis routines. The algorithm server additionally accesses a plurality of digital slides. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. The digital slide is accessed locally or remotely across a network. Similarly, the image processing and analysis routines are accessed locally or remotely across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely accessed routines. Use of image processing and analysis routines may be restricted through a monitor process that authenticates requests to process or view digital slides. Variations in restrictions to images provide rich diversity in access levels that allow sharing of digital slides and demonstrations of image processing algorithms. | 11-08-2012 |
20130271594 | ACHIEVING FOCUS IN A DIGITAL PATHOLOGY SYSTEM - Methods and apparatus are provided for computing focus information during scanning digital microscope slide data with a line scan camera. The systems and methods include a dynamically interleaved procedure that works by moving the specimen relative to the objective lens while the height of the objective lens is adjusted relative to the stage. Imagery data is acquired at a plurality of objective lens heights the image data from the objective lens height having maximum contrast is stored and combined into a composite digital image of at least a portion of the specimen. | 10-17-2013 |
20130279807 | IMAGE PROCESSING AND ANALYSIS FRAMEWORK - A system and method for processing and analyzing virtual microscopy digital images (“digital slides”) is provided. The system comprises an algorithm server that accesses a plurality of image processing and analysis routines. The algorithm server additionally accesses a plurality of digital slides. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. The digital slide is accessed locally or remotely across a network. Similarly, the image processing and analysis routines are accessed locally or remotely across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely accessed routines. Use of image processing and analysis routines may be restricted through a monitor process that authenticates requests to process or view digital slides. Variations in restrictions to images provide rich diversity in access levels that allow sharing of digital slides and demonstrations of image processing algorithms. | 10-24-2013 |
20140300724 | OPTIMIZING VIRTUAL SLIDE IMAGE QUALITY - Systems, methods, and media for assessing the quality of a microscope slide image. In an embodiment, a plurality of focus point values are acquired for a sample on a microscope slide. Each focus point value comprises x-y coordinates indicating a location on the sample and a z coordinate indicating a focus height for the location on the sample. A best-fit surface is calculated based on the focus point values, and it is determined whether or not outlying focus point values exist based on the best-fit surface and the z coordinate for one or more of the focus point values. A scanned image of the microscope slide may be displayed which comprises, for each outlying focus point value, an overlay that identifies the location on the sample of the outlying focus point value based on the x-y coordinates for the outlying focus point value. | 10-09-2014 |
20140301664 | IMAGE PROCESSING AND ANALYSIS FRAMEWORK - Method, systems, and media for processing a digital slide image. In an embodiment, an identification of a macro, representing a plurality of algorithms, and an identification of digital slide image(s) are received over a network. Parameter data is obtained for the identified macro, and the digital slide image(s) are retrieved. The plurality of algorithms represented by the identified macro are executed on the digital slide image(s) according to the parameter data. | 10-09-2014 |
Patent application number | Description | Published |
20090028414 | Data Management in a Linear-Array-Based Microscope Slide Scanner - Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays. | 01-29-2009 |
20110044518 | Data Management in a Linear-Array-Based Microscope Slide Scanner - Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays. | 02-24-2011 |
20110221882 | Data Management in a Linear-Array-Based Microscope Slide Scanner - Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays. | 09-15-2011 |
20120113242 | Data Management in a Linear-Array-Based Microscope Slide Scanner - Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays. | 05-10-2012 |
20140313314 | Data Management in a Linear-Array-Based Microscope Slide Scanner - Systems and methods for capturing image data using a line scan camera. In an embodiment, a line scan camera captures image data of a sample as a plurality of image stripes. A processor may coarsely align two or more of the plurality of image stripes according to a synchronization process while the line scan camera is capturing at least one of the plurality of image stripes. Subsequently, the processor may also finely align the two or more image stripes using pattern matching. | 10-23-2014 |
Patent application number | Description | Published |
20090139730 | MECHANICAL SEAL AND LOCK FOR TUBING CONVEYED PUMP SYSTEM - A through tubing conveyed electrical submersible pumping system for use in a wellbore. The system includes a tubing string with an attached deployed drive system having a pump motor and a pump engaging receptacle, a pumping assembly insertable into the tubing deployed system, and sealing elements on both the tubing string and pumping assembly. Engaging the sealing elements while inserting the pumping assembly forms a seal. The system further includes mating latch members on the pumping assembly and the tubing string, the latch members selectively activated by engaging one another. The latch may include locking fingers disposed on the pumping system and a shoulder protruding into the tubing string; wherein inserting the pumping system into the tubing deployed system locking fingers with the shoulder for securing the pumping system to the tubing string. | 06-04-2009 |
20090145612 | High Velocity String for Well Pump and Method for Producing Well Fluid - A method of producing a well fluid includes securing a motor to a string of outer tubing and lowering the outer tubing and motor into the well. A rotary pump is secured to a string of inner tubing and lowered into the outer tubing. The pump stabs into cooperative engagement with the motor. Supplying power to the motor rotates the pump, causing well fluid to flow into the outer tubing to an intake of the pump, which pumps the well fluid through the inner tubing to an upper end of the well. Removing the well fluid allows gas to flow up an annulus surrounding the outer tubing to the upper end of the well. | 06-11-2009 |
20110284238 | INSERTABLE SURFACE-DRIVEN PUMP - Wellbore tubing having an annular seating member and an annular anti-rotation member can be used for one or more types of surface driven submersible pumps. In one embodiment, a stator and a rotor of a surface driven progressing cavity pump can be inserted into the tubing after the tubing is deployed. In one embodiment, a surface driven reciprocating pump can be inserted into the tubing, later withdrawn from the tubing, and then a progressing cavity pump can be inserted into the same tubing. | 11-24-2011 |
20120175131 | ID Centralizer - An apparatus and methods of spacing a tool from walls of tubing are provided as embodiments of the present invention. The apparatus can include a centralizer that is inserted in the tubing, the centralizer having inwardly arched sides or inwardly arched bow springs so that an inner diameter of the centralizer increases from a longitudinal midpoint to a longitudinal end point of the centralizer. The centralizer has a smaller diameter than the tubing so that it can be positioned inside of the tubing downstream of a seating ring in a relaxed position so that when the tool passes through the centralizer, the inwardly arched sides or inverted bow springs expand towards an inner wall of the tubing to centralize and inhibit radial movement of the tool when deployed through the inwardly arched sides of the centralizer. | 07-12-2012 |
Patent application number | Description | Published |
20100093295 | Direct conversion tuner - A direct conversion tuner down-converts television signals, cable signals, or other signals directly from an RF frequency to an IF frequency and/or baseband, without an intermediate up-conversion step for image rejection. The direct conversion tuner includes a pre-select filter, an amplifier, an image reject mixer, and a poly-phase filter. The pre-select filter, amplifier, and the image reject mixer can be calibrated to provide sufficient image rejection to meet the NTSC requirements for TV signals. The entire direct conversion tuner can be fabricated on a single semiconductor substrate without requiring any off-chip components. The tuner configuration described herein is not limited to processing TV signals, and can be utilized to down-convert other RF signals to an IF frequency or baseband. | 04-15-2010 |
20100216504 | WIRELESS DEVICE AUTHENTICATION AT MUTUAL REDUCED TRANSMIT POWER - A system and method for facilitating the authentication of wireless devices in an environment with multiple wireless networks. A user wishing to join an operating wireless network can bring his wireless device within close physical proximity, for example, less than one meter, of a device in the network that he wishes to join. The user then presses an authenticate button, which causes both devices to enter a low transmission power mode. In such case, the devices are only capable of operation within the close proximity. Being in low power mode will diminish the possibility of eavesdropping on the authentication process. Power down mode also reduces the amount of message traffic in the area and saves scarce power and processing resources at the nodes, which are now out of range. Authentication then takes place in low power mode and once completed, both devices resume normal power levels and continue communicating normally. | 08-26-2010 |
Patent application number | Description | Published |
20080259498 | PERPENDICULAR WRITE HEAD WITH INDEPENDENT TRAILING SHIELD DESIGNS - A magnetic write head having independent trailing and side magnetic shields. The side shields and trailing shields are independently of one another so that they can have throat heights that are different from one another. This advantageously allows the magnetic potential between the write pole and side shields to be controlled independently of one another without relying on the side gap and trailing gap thicknesses. Furthermore, magnetic performance of the write head can be improved because the side shields can be constructed with varying tapered throat heights, while the throat height of the trailing shield can remain constant. | 10-23-2008 |
20080316630 | USING INDUCTANCE TO MEASURE WRITER SPACING IN PERPENDICULAR MAGNETIC RECORDING - A magnetic data recording system that can directly measure soft underlayer spacing of a perpendicular magnetic write head during operation. The soft underlayer spacing of the magnetic write head can be determined by measuring the magnetic inductance of the write head. The inductance of the write head varies with changes in the distance between the write pole and the soft underlayer of the magnetic medium. By connecting the write head with magnetic inductance measuring circuitry, the soft underlayer spacing can be constantly monitored during operation of the magnetic data recording system. The system can also include active fly height control such as a thermal fly height control capability. By directly measuring the soft underlayer spacing in real time during use of the data recording system, the actively fly height controlling features can be operated efficiently to precisely maintain a desired spacing between the write pole and the soft underlayer of the magnetic medium. | 12-25-2008 |
20090155627 | DISCRETE TRACK MEDIA WITH A CAPPED MEDIA STRUCTURE HAVING HIGH MOMENT AND EXCHANGE - A media architecture is optimized for discrete track recording. A capped or exchange-spring media uses a thin media structure and incorporates higher moment density magnetic layers. A thin exchange coupling layer is used in conjunction with a cap layer to control the reversal mechanism and exchange. Thus, the exchange coupling layer mediates the interaction between the two outer magnetic layers. The thickness of the exchange coupling layer is tuned by monitoring the media signal-to-noise ratio, track width and bit error rate. The recording performance is enhanced by tuning the intergranular exchange in the system through the use of the high-moment cap as writeability, resolution and noise are improved. | 06-18-2009 |
20090195902 | METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR ESTIMATING ADJACENT TRACK ERASURE RISK BY DETERMINING ERASE BAND WIDTH GROWTH RATES - A method according to one embodiment comprises determining a growth rate of an erase band width between an aggressor track and a substantially unerased portion of a data track on a magnetic medium during a first number of write cycles on the aggressor track; and estimating the erase band width, or derived parameter thereof, for or after a second number of write cycles on the aggressor track, the second number of write cycles being greater than the first number of write cycles. | 08-06-2009 |
20090290454 | Thermally assisted recording head with magnetic pole integrated into optical aperture for dual gradient recording - A write head structure for perpendicular recording having a pole tip integrated into the metal film surrounding a C aperture near field light source is disclosed. The close proximity of the pole tip to the light source enables more precise location of data cells written into the magnetic media, through the use of dual gradient thermally assisted recording. In dual gradient recording, data is fixed by the effect of both a thermal gradient, which affects the coercivity of the magnetic media, combined with a magnetic field gradient imposed by the pole tip. | 11-26-2009 |
20100277827 | Correcting Errors in Position of an HDD Write-Head - A hard-disk drive (HDD) with a current adjustment component is provided. The current adjustment component changes an amount of current to a magnetic-recording head of the HDD to cause a change in the strength of a magnetic write field produced by the magnetic-recording head in response to a determination that a present position of the magnetic-head head is not in a desired position. To illustrate, in response to a determination that the present position of the magnetic-recording head is further away from an edge of a current track being written than a desired position of the magnetic-recording head, the current adjustment component increases the current to the magnetic-recording head to cause an increase in the strength of the magnetic write field. The change in the strength of the magnetic write field causes data, written by the magnetic-recording head, to be located at a desired location on the magnetic-recording disk. | 11-04-2010 |
20110069413 | CURRENT-PERPENDICULAR-TO-THE-PLANE (CPP) MAGNETORESISTIVE READ HEAD WITH MULTIPLE SENSING ELEMENTS FOR PATTERNED-MEDIA - A magnetoresistive (MR) sensor or read head for a magnetic recording disk drive has multiple independent current-perpendicular-to-the-plane (CPP) MR sensing elements. The sensing elements are spaced-apart in the cross-track direction and separated by an insulating separation region so as to be capable of reading data from multiple data tracks on the disk. The sensing elements have independent CPP sense currents, each of which is directed to independent data detection electronics, respectively. Each sensing element comprises a stack of layers formed on a common electrically conducting base layer, which may be a bottom magnetic shield layer formed of electrically conducting magnetically permeable material. Each sensing element has a top electrical lead layer. A top magnetic shield layer is located above the sensing elements in contact with the top lead layers. The top shield layer is formed of soft magnetically permeable material, but is electrically insulating, so that the independent sense currents can be passed to the independent sensing elements. | 03-24-2011 |
Patent application number | Description | Published |
20090098588 | BETA GALACTOSIDASE DONOR FRAGMENTS - Truncated fragments of the small fragment of β-galactosidase are provided that have low affinity for the large fragment of β-galactosidase and provide for robust signals when two fusion proteins are complexed due to the binding of the proteins to which the β-galactosidase fragments are fused. The truncated fragments do not interfere with the complexing of the two proteins and allow for the two proteins to function and be responsive to candidate compounds that affect complex formation. | 04-16-2009 |
20100041052 | Receptor Tyrosine Kinase Assays - Methods for detecting phosphorylation of receptor tyrosine kinases (“RTKs”) upon activation are provided. The method employs cells comprising two fusion products: (1) an RTK fused to a small fragment of β-galactosidase and (2) a phosphotyrosine binding peptide fused to the large fragment of β-galactosidase, where the 2 fragments weakly complex to form an active enzyme, and optionally a construct for a cytosolic RTK phosphorylating kinase, when the RTK does not autophosphoryate. To detect phosphorylation a β-galactosidase substrate is added to the cells, whereby product formation indicates the occurrence of phosphorylation. | 02-18-2010 |
20100120063 | GPCR Arrestin Assays - Sensitive assays for candidate compounds affecting GPCR activity are provided using a cell containing fusion proteins comprising a first fusion protein comprising (a) a target GPCR fused to a small fragment of β-galactosidase through a linker comprising a phosphorylation site or (b) a GPCR or a protein of interest, where the GPCR and protein of interest form a complex and one of them is fused to the small fragment of β-galactosidase; and a second fusion protein comprising arrestin fused to a large fragment of β-galactosidase. In (a), the affinity of the small and large fragments is optimized based on the background to signal ratio and the absolute signal observed. The assay is performed using a β-galactosidase substrate that provides a detectable optical signal. | 05-13-2010 |
20100151496 | ASSAYS FOR NUCLEAR HORMONE RECEPTOR BINDING - Methods and genetic constructs are provided for detecting the binding of nuclear hormone receptors to a coactivator/corepressor. The methods employ enzyme fragment complementation using fragments of β-galactosidase as the detection system. Cells are transformed to express the large fragment of β-galactosidase fused to a member of the complex with NHR for initiation of transcription and have it localized in the nucleus and to express the small fragment of β-galactosidase fused to the nuclear hormone receptor for binding to the member upon stimulation with a ligand. | 06-17-2010 |
20120040372 | RECEPTOR TYROSINE KINASE ASSAYS - Methods for detecting phosphorylation of receptor tyrosine kinases (“RTKs”) upon activation and the modulation of activation by a candidate compound are provided. The method employs cells comprising two fusion products: (1) an RTK fused to a small fragment of β-galactosidase and (2) a phosphotyrosine binding peptide fused to the large fragment of β-galactosidase, where the 2 fragments weakly complex to form an active enzyme, and optionally a construct for a cytosolic RTK phosphorylating kinase, when the RTK does not autophosphoryate. To detect phosphorylation a β-galactosidase substrate is added to the cells, whereby product formation indicates the occurrence of phosphorylation. | 02-16-2012 |
Patent application number | Description | Published |
20080293637 | Cross-linked collagen and uses thereof - The present invention discloses collagen cross-linked in a micro to non-fibrillar form and at a high concentration. The cross-linked collagen gel has improved volume stability or persistence than collagen cross-linked at a neutral pH. Also disclosed are methods for preparing the inventive cross-linked collagen and using such for augmenting soft tissues in mammals. | 11-27-2008 |
20090093755 | CROSSED-LINKED HYALURONIC ACID AND COLLAGEN AND USES THEREOF - The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone. Also disclosed are methods for preparing cross-linked hyaluronic acid/collagen formulations and using such for augmenting soft tissues in mammals. | 04-09-2009 |
20100099623 | Cross-Linked Collagen and Uses Thereof - The present invention discloses collagen cross-linked in a micro to non-fibrillar form and at a high concentration. The cross-linked collagen gel has improved volume stability or persistence than collagen cross-linked at a neutral pH. Also disclosed are methods for preparing the inventive cross-linked collagen and using such for augmenting soft tissues in mammals. | 04-22-2010 |
20100099624 | CROSS-LINKED COLLAGEN AND USES THEREOF - The present invention discloses collagen cross-linked in a micro to non-fibrillar form and at a high concentration. The cross-linked collagen gel has improved volume stability or persistence than collagen cross-linked at a neutral pH. Also disclosed are methods for preparing the inventive cross-linked collagen and using such for augmenting soft tissues in mammals. | 04-22-2010 |
20120164098 | CROSSED-LINKED HYALURONIC ACID AND COLLAGEN AND USES THEREOF - The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone. Also disclosed are methods for preparing cross-linked hyaluronic acid/collagen formulations and using such for augmenting soft tissues in mammals. | 06-28-2012 |
Patent application number | Description | Published |
20110029367 | Systems and Methods to Generate Transactions According to Account Features - Systems and methods are provided to facilitate the generation and notification of transactions associated with account features. In one aspect, a system includes a transaction handler to process transactions and a data warehouse to store transaction data recording the transactions, account data identifying at least one account feature of an account, and rules data identifying at least one qualification requirement. The system further includes a feature offer engine to use the rules data to monitor the transactions in the account to identify a first transaction, a notification engine to provide the account holder with an offer associated with a first account feature in real time with processing of the first transaction, and a portal to receive an approval of a second transaction in accordance with the offer. | 02-03-2011 |
20110029430 | Systems and Methods to Provide Benefits of Account Features to Account Holders - Systems and methods are provided to facilitate the sharing of account features. In one aspect, a system includes a transaction handler to process transactions and a data warehouse to record the transactions and store account data identifying account features of separate accounts, such as a second account having a feature and a first account without this feature. Account holders of the first and second accounts are in a same household and thus, in accordance with a set of rules, eligible to share the account features. A portal is configured to receive a request identifying the first account and to determine whether a transaction initiated in the first account and qualified for a benefit of the account feature is entitled to the benefit; and if so, a notification engine is to transmit a notification message to an account holder of the first account. | 02-03-2011 |
20130054463 | Dynamic Level Assessment - Embodiments of the present invention include a dynamic and auditable rules-based spend requirement management (SRM) server configured to receive transaction data associated with a payment transaction involving an issuer of an account, where the account is associated with a first set of account level requirements (e.g., a minimum spend requirement) and a first interchange rate. The SRM is further configured to determine that the transaction data is not within the first set of account level requirements, but is within a second set of account level requirements associated with a second interchange rate, and associate the account to the second set of account level requirements by way of a final product identifier stored in a database accessible by a payment processing network (PPN). | 02-28-2013 |
Patent application number | Description | Published |
20090278233 | BONDED INTERMEDIATE SUBSTRATE AND METHOD OF MAKING SAME - A method includes growing a first epitaxial layer of III-nitride material, forming a damaged region by implanting ions into an exposed surface of the first epitaxial layer, and growing a second epitaxial layer of III-nitride material on the exposed surface of the first epitaxial layer. A level of defects present in the second epitaxial layer is less than a level of defects present in the first epitaxial layer. | 11-12-2009 |
20130022731 | HIGH PROTEIN, LOW CARBOHYDRATE MEAL REPLACEMENTS AND FOOD - Protein-based meal replacements and foods, methods of manufacturing the protein-based meal replacements and foods, and different forms of the protein-based meal replacements and foods are disclosed. Implementations of the invention include combinations of egg based materials and value-added ingredients processed to form desired end products. Examples of end products include, but are not limited to, snack chips, crisps, croutons, French fries, cookies, donuts, breads, taco shells, tortillas, cereal, coatings, and other types of fried, baked, puffed, and/or otherwise cooked products. | 01-24-2013 |
Patent application number | Description | Published |
20100121349 | TERMINATION DEVICES AND RELATED METHODS - Devices and methods for locking and/or cutting tethers during a tissue modification procedure are described. In some variations, a tether may be used to tighten tissue by bringing two pieces or sections of the tissue together. The tether, which may be under tension, may be locked to maintain the tension, and excess tether may be severed, using one or more of the devices and/or methods. The devices and/or methods may be used, for example, in minimally invasive procedures. | 05-13-2010 |
20140188140 | TERMINATION DEVICES AND RELATED METHODS - Devices and methods for locking and/or cutting tethers during a tissue modification procedure are described. In some variations, a tether may be used to tighten tissue by bringing two pieces or sections of the tissue together. The tether, which may be under tension, may be locked to maintain the tension, and excess tether may be severed, using one or more of the devices and/or methods. The devices and/or methods may be used, for example, in minimally invasive procedures. | 07-03-2014 |
Patent application number | Description | Published |
20100009338 | Novel gold nanostructures and methods of use - The invention is drawn to novel nanostructures comprising hollow nanospheres and nanotubes for use as chemical sensors, conduits for fluids, and electronic conductors. The nanostructures can be used in microfluidic devices, for transporting fluids between devices and structures in analytical devices, for conducting electrical currents between devices and structure in analytical devices, and for conducting electrical currents between biological molecules and electronic devices, such as bio-microchips. | 01-14-2010 |
20120045754 | NOVEL GOLD NANOSTRUCTURES AND METHODS OF USE - The invention is drawn to novel nanostructures comprising hollow nanospheres and nanotubes for use as chemical sensors, conduits for fluids, and electronic conductors. The nanostructures can be used in microfluidic devices, for transporting fluids between devices and structures in analytical devices, for conducting electrical currents between devices and structure in analytical devices, and for conducting electrical currents between biological molecules and electronic devices, such as bio-microchips. | 02-23-2012 |
20140012224 | Targeted hollow gold nanostructures and methods of use - Provided are novel nanostructures comprising hollow nanospheres (HGNs) and nanotubes for use as chemical sensors, molecular specific photothermal coupling agents, and photothermal ablation compounds. The nanostructures can be used in electromagnetic radiation-induced phototherapy for treatment of cancer and other disorders. The nanostructures can also be used as a sensor that detects molecules. The nanostructures are of particular use in the fields of clinical diagnosis, clinical therapy, clinical treatment, and clinical evaluation of various diseases and disorders, manufacture of compositions for use in the treatment of various diseases and disorders, for use in molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. The hollow gold nanospheres have a unique combination of spherical shape, small size, and strong, tunable, and narrow surface plasmon resonance absorption covering the entire visible to near IR region. | 01-09-2014 |
Patent application number | Description | Published |
20090168712 | Rapid search for optimal wireless network configuration - A search algorithm to find a globally optimal radio plan for a wireless network, including assignments of frequency and transmission power to multiple access points. Two different evaluation metrics are used in order to provide an optimal solution in a reasonable time period. Frequency searches are performed using a special rapid evaluation metric. Transmission powers are selected using a more refined metric that estimates data throughput. The search results are deterministic and execution time is also substantially deterministic. | 07-02-2009 |
20090235077 | NETWORK INFRASTRUCTURE VALIDATION OF NETWORK MANAGEMENT FRAMES - A detection-based defense to a wireless network. Elements of the infrastructure, e.g., access points or scanning-only access points, detect intruders by detecting spoofed frames, such as from rogue access points. Access points include a signature, such as a message integrity check, with their management frames in a manner that enables neighboring access points to be able to validate the management frames, and to detect spoofed frames. When a neighboring access point receives a management frame, obtains a key for the access point sending the frame, and validates the management frame using the key. | 09-17-2009 |
20120134290 | RAPID SEARCH FOR OPTIMAL WIRELESS NETWORK CONFIGURATION - A search algorithm to find a globally optimal radio plan for a wireless network, including assignments of frequency and transmission power to multiple access points. Two different evaluation metrics are used in order to provide an optimal solution in a reasonable time period. Frequency searches are performed using a special rapid evaluation metric. Transmission powers are selected using a more refined metric that estimates data throughput. The search results are deterministic and execution time is also substantially deterministic. | 05-31-2012 |
20120210395 | NETWORK INFRASTRUCTURE VALIDATION OF NETWORK MANAGEMENT FRAMES - A detection-based defense to a wireless network. Elements of the infrastructure, e.g., access points or scanning-only access points, detect intruders by detecting spoofed frames, such as from rogue access points. Access points include a signature, such as a message integrity check, with their management frames in a manner that enables neighboring access points to be able to validate the management frames, and to detect spoofed frames. When a neighboring access point receives a management frame, obtains a key for the access point sending the frame, and validates the management frame using the key. | 08-16-2012 |
20130333012 | NETWORK INFRASTRUCTURE VALIDATION OF NETWORK MANAGEMENT FRAMES - A detection-based defense to a wireless network. Elements of the infrastructure, e.g., access points or scanning-only access points, detect intruders by detecting spoofed frames, such as from rogue access points. Access points include a signature, such as a message integrity check, with their management frames in a manner that enables neighboring access points to be able to validate the management frames, and to detect spoofed frames. When a neighboring access point receives a management frame, obtains a key for the access point sending the frame, and validates the management frame using the key. | 12-12-2013 |
Patent application number | Description | Published |
20080250500 | Man-In-The-Middle Attack Detection in Wireless Networks - Detection of a man-in-the-middle attack. In particular implementations, a method includes detecting a first event comprising notification of an invalid wireless management frame operable to cause a termination of a connection between a wireless client and a wireless access point, wherein the notification is based on a failed verification of a management integrity code (MIC) appended to the wireless management frame. The method also includes detecting a second event involving notification of either an authentication failure associated with the wireless client or a connection between the wireless client and a rogue access point. The method also includes performing one or more actions upon detection of the first event and the second event within a threshold period of time of each other. | 10-09-2008 |
20090168676 | Wireless Interface Control To Reduce Power Consumption - A wireless mobile unit includes a first wireless interface configured to at least receive communication over a first wireless network. A second wireless interface is configured to provide for bidirectional communication over a second wireless network. An interface control is operative to control activation of the second wireless interface from an off state to an on state in response to a predefined radio frequency (RF) stimulus, the first wireless interface remaining in an on state regardless of the state of the second wireless interface. | 07-02-2009 |
20090170501 | SCANNING FOR A WIRELESS DEVICE - A system and method are disclosed to achieve improvements in scanning that can be implemented by a wireless device. A method to control scanning performed by a mobile unit includes detecting the presence or absence of audio for transmission from the mobile unit. A performance of a scan can be deferred depending on the detection of the presence or absence of audio. | 07-02-2009 |
20090262733 | DYNAMIC CALL ANCHORING - A system for dynamically anchoring a call initiated by a mobile unit can include call anchor logic programmed with anchoring criteria to determine if a new outbound call being initiated from the mobile unit should be anchored at an anchor point located outside of a service provider network for the mobile unit based on application of the anchoring criteria to input data. The call anchor logic provides an anchor control signal to cause the outbound call to be one of (i) anchored at the anchor point and (ii) connected to a called party without anchoring at the anchor point. Memory that stores the input data, the memory being accessible by the call anchor logic. | 10-22-2009 |
20100009674 | CLIENT-CONTROLLED HANDOVER BETWEEN RADIO TECHNOLOGIES - In one embodiment a mobile client includes a first voice interface configured to communicate voice media via a first radio technology. A second voice interface is configured to communicate voice media via a second radio technology, which is different from the first radio technology. A data interface can communicate data via at least one of the first radio technology and the second radio technology. Call control is programmed to control the data interface to perform signaling from the mobile client for establishing parameters for a voice media session between the mobile client and a third party via a selected one of the first voice interface and the second voice interface The call control controls the signaling from the mobile client depending on which of the first voice interface and the second voice interface the call control determines to utilize for the voice media session. | 01-14-2010 |
20100048180 | SYSTEM AND METHOD FOR VOICEMAIL SERVICE MOBILITY - A method for utilizing a common voicemail box for a fixed-mobile convergence device includes automatically providing a confirmation message from a mobile client to an enterprise system in response to an enterprise call from the enterprise system being answered by a user at the mobile client. An incoming call from a calling party is connected with the mobile client in response to the confirmation message being received by the enterprise system to indicate that the enterprise call has been answered by the user at the mobile client. The incoming call is connected to a voicemail box associated with the mobile client (e.g., enterprise voicemail) in response to determining that the user did not answer the incoming call at the mobile client. | 02-25-2010 |
20120002553 | Troubleshooting Link and Protocol in a Wireless Network - Methods, apparatuses, and systems directed to facilitating troubleshooting wireless connectivity issues in a wireless network. In accordance with one embodiment of the present invention, either a diagnostic supplicant in the wireless client or a diagnostic manager initiates a troubleshooting protocol between the diagnostic supplicant and the diagnostic manager over a diagnostic link in response to one or more events. In one embodiment, after the diagnostic supplicant establishes a link to a diagnostic manager via a diagnostic link, the diagnostic supplicant generates and transmits a problem report to the diagnostic manager. The problem report initiates a troubleshooting protocol between the diagnostic manager and the diagnostic supplicant. | 01-05-2012 |
20120149380 | COMPUTER READABLE MEDIUM AND METHOD TO FACILITATE HANDOVER - A computer readable medium has machine readable instructions that can include a fingerprint detector to evaluate input data relative to mobility fingerprint data that defines at least one predetermined zone that is a proper subset of overlap in coverage areas between first and second radio technologies to determine whether to trigger a handover between the first and second radio technologies for a mobile unit based on an evaluation of the mobility fingerprint data relative to the input data | 06-14-2012 |
20120309389 | DYNAMIC CALL ANCHORING - A non-transitory computer-readable medium can include includes instructions to perform dynamic call anchoring. The instructions can include call anchor logic programmed to determine if an outbound call leg being initiated from a mobile unit should be anchored at an anchor point based on evaluating anchoring criteria to input data. The call anchor logic can providing an anchor control signal to cause the outbound call leg to be one of (i) anchored at the anchor point or (ii) connected to a called party without anchoring at the anchor point. The anchor point can correspond to a node in an associated private network where the outbound call leg and another call leg are connected together that is outside of a service provider network for the mobile unit. | 12-06-2012 |
20130295854 | Troubleshooting Link and Protocol in a Wireless Network - Methods, apparatuses, and systems directed to facilitating troubleshooting wireless connectivity issues in a wireless network. In accordance with one embodiment of the present invention, either a diagnostic supplicant in the wireless client or a diagnostic manager initiates a troubleshooting protocol between the diagnostic supplicant and the diagnostic manager over a diagnostic link in response to one or more events. In one embodiment, after the diagnostic supplicant establishes a link to a diagnostic manager via a diagnostic link, the diagnostic supplicant generates and transmits a problem report to the diagnostic manager. The problem report initiates a troubleshooting protocol between the diagnostic manager and the diagnostic supplicant. | 11-07-2013 |
20130337780 | COMPUTER READABLE MEDIUM AND SYSTEM FOR VOICEMAIL SERVICE MOBILITY - A non-transitory computer readable medium can include instructions for performing a method. The method can include receiving, at a mobile client, an enterprise call from an enterprise system in response to an incoming call from a calling party to the enterprise system. The method can also include determining, at the mobile client, whether the enterprise call is anchored in the enterprise system. If the enterprise call is determined to be anchored in the enterprise system, a confirmation message can be provided from the mobile client to the enterprise system in response to the enterprise call being answered for voice communication at the mobile client. | 12-19-2013 |
20140274200 | COMMUNICATIONS CONTROL BETWEEN MOBILE DEVICE AND PERIPHERAL DEVICE - A non-transitory computer-readable medium can include instructions for performing a method that includes docking a mobile device with a docking station using at least one physical connection and at least one wireless connection to provide communication between the mobile device and the docking station. One of the physical or wireless connections can be selected for providing a signaling channel for communication of signaling data between the mobile device and the docking station. Independently of the signaling channel, one of the physical or wireless connections can be selected for providing a media channel for communication of media data between the mobile device and the docking station. | 09-18-2014 |
Patent application number | Description | Published |
20100021183 | RF Signal Power Regulation in Optical Transmitters - A circuit controlling the gain of an amplifier in an optical transmitter used for optical communication, including a detection circuit for measuring the power of the RF input to said laser; a gain controller for controlling a gain of said amplifier, and a switch connected to said gain controller, wherein said gain controller is adapted, in response to an activation of said switch, to: (i) automatically vary said gain of said amplifier, and (ii) set said gain of said amplifier at a level corresponding to a reduction in the noise and/or distortion associated with the transmitter. | 01-28-2010 |
20100158062 | Adapted Semiconductor Laser Package - An adapted semiconductor laser package that may convert a first type of package pin-out arrangement to a desired pin-out arrangement. The laser package may include a laser package including a laser, an isolator, a lens, a fiber sleeve, and a pin-out arrangement. The isolator and the fiber sleeve may be jointly arranged away from the laser. The laser package may also include an adapter with a first section with a plurality of holes geometrically arranged and mated with the package pin-out arrangement, a second section with an adapter pin-out arrangement with two rows of pins extending along opposite sides of the package, and electrical connections between the plurality of holes and the pins. | 06-24-2010 |
Patent application number | Description | Published |
20100155366 | METHOD FOR CREATING A MAGNETIC WRITE POLE HAVING A STEPPED PERPENDICULAR POLE VIA CMP-ASSISTED LIFTOFF - A method for manufacturing a magnetic write head having a stepped, recessed, high magnetic moment pole connected with a write pole. The stepped pole structure helps to channel magnetic flux to the write pole without leaking write field to the magnetic medium. This allows the write head to maintain a high write field strength at very small bit sizes. The method includes depositing a dielectric layer and a first CMP layer over substrate that can include a magnetic shaping layer. A mask is formed over the dielectric layer, the mask having an opening to define the stepped pole structure. The image of the mask is transferred into the dielectric layer. A high magnetic moment material is deposited and a chemical mechanical polishing is performed to planarize the magnetic material and dielectric layer. | 06-24-2010 |
20100157470 | METHODS FOR CREATING SLANTED PERPENDICULAR MAGNETIC POLE VIA METAL LIFTOFF - A method in one embodiment includes forming a resist structure above an upper surface of a substrate, wherein a portion of the upper surface of the substrate is a shaping layer, wherein the resist structure has an undercut; depositing a layer of magnetic material above exposed regions of the substrate, wherein a portion of the layer of magnetic material tapers towards the substrate as it approaches the undercut; removing the resist structure; and forming a write pole above the layer of magnetic material. Additional methods are disclosed. | 06-24-2010 |
20100159154 | METHODS FOR CREATING A STEPPED PERPENDICULAR MAGNETIC POLE VIA MILLING AND/OR METAL LIFTOFF - A method in one embodiment includes forming a layer of a nonmagnetic material above an upper surface of a substrate; forming a resist structure above the layer of nonmagnetic material, wherein the resist structure has an undercut; removing a portion of the layer of nonmagnetic material not covered by the resist structure; depositing a layer of magnetic material above the substrate adjacent a remaining portion of the layer of nonmagnetic material such that at least portions of the layer of magnetic material and the remaining portion of the layer of nonmagnetic material lie in a common plane; removing the resist structure; and forming a write pole above the layer of magnetic material and the remaining portion of the layer of nonmagnetic material. Additional methods are also presented. | 06-24-2010 |
20110075299 | MAGNETIC WRITE HEADS FOR HARD DISK DRIVES AND METHOD OF FORMING SAME - Embodiments provide a write pole and a magnetic shield for write heads. The write pole includes a trailing step, while the magnetic shield includes a slanted bump. The slanted bump and the trailing step provides maximize magnetic flux for writing to a magnetic media such as a magnetic storage disk in a hard disk drive, while avoiding saturation. One embodiment of a method for forming the write pole includes depositing non-magnetic gap material on the write pole and trailing step. An ion beam milling process is used to form a taper in the non-magnetic gap material. The magnetic shield is then deposited on the taper, forming the slanted bump of the shield. | 03-31-2011 |
20110076393 | TRAILING PLATED STEP - Methods for fabrication of magnetic write heads, and more specifically to fabrication of magnetic poles and trailing magnetic pole steps. A write pole may first be patterned on a substrate. Then a side gap material may be patterned along sidewall portions of the write pole. Thereafter, a masking layer may be deposited and patterned to expose a portion of the write pole. A trailing magnetic pole step may be formed on the exposed portion of the write pole. | 03-31-2011 |
Patent application number | Description | Published |
20100125253 | Dual-tip Catheter System for Boring through Blocked Vascular Passages - A dual-tip catheter equipped with both a rotating cutting bit and a cavity for a probing guidewire tip for passage through chronic total occlusions or other refractory atherosclerotic plaque from diseased arteries. The catheter's guidewire tip and rotating cutting bit reside safely within an outer protective catheter sheath head when not in use, and alternately either the cutting bit or the guidewire tip will protrude out of the same distal opening of the sheath head as needed. By first drilling through refractory occlusions, and then inserting a guidewire tip into the occlusion opening formed by the cutting bit, the catheter can force the guidewire tip past the occlusion. After the guidewire tip has been fully inserted, the dual-tip catheter can be withdrawn, and an alternate catheter inserted and directed up the guidewire to the occlusion site, where the alternate catheter can perform further occlusion enlargement or therapeutic activity. | 05-20-2010 |
20120016395 | HIGH CAPACITY DEBULKING CATHETER WITH DISTAL DRIVEN CUTTING WHEEL - The present invention is an atherectomy catheter with a rotary cutting knife that is driven from the distal (nose) or side (circumference) direction. The catheter collects plaque shavings in a hollow collection chamber mounted in between the rotary cutting knife and the main catheter tubing. In contrast to prior art designs, which utilized nose mounted plaque collection chambers, the present design is able to store a substantially larger volume of removed plaque, thus increasing the length of time and amount of plaque removal that can be accomplished before the catheter must be removed from the body and cleaned. This decreases medical procedure time, allows for more complete and careful plaque removal, and reduces the burden on the patient and physician. | 01-19-2012 |
20130289590 | HIGH CAPACITY DEBULKING CATHETER WITH DISTAL DRIVEN CUTTING WHEEL - The present invention is an atherectomy catheter with a rotary cutting knife that is driven from the distal (nose) or side (circumference) direction. The catheter collects plaque shavings in a hollow collection chamber mounted in between the rotary cutting knife and the main catheter tubing. In contrast to prior art designs, which utilized nose mounted plaque collection chambers, the present design is able to store a substantially larger volume of removed plaque, thus increasing the length of time and amount of plaque removal that can be accomplished before the catheter must be removed from the body and cleaned. This decreases medical procedure time, allows for more complete and careful plaque removal, and reduces the burden on the patient and physician. | 10-31-2013 |
20130296901 | DEBULKING CATHETER - A catheter includes a rotatable cutter in a catheter body adjacent a window and operatively connected to a rotatable shaft for rotation therewith. The rotatable cutter includes a proximally-facing cutting edge. The rotatable cutter is selectively positionable to a cutting position in which the rotatable cutter extends partially outside the window to expose the cutting edge such that the catheter can be moved proximally within the body lumen as the rotatable cutter is rotating to remove tissue from the lumen and direct the removed tissue through the window and into a removed-tissue lumen. | 11-07-2013 |