Patent application number | Description | Published |
20110105533 | Heterocyclic Sulfonamides, Uses and Pharmaceutical Compositions Thereof - The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: | 05-05-2011 |
20110172297 | Oxopiperdinyl And Pyranyl Sulfonamides and Pharmaceutical Compositions Thereof - The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of Formula (I): as defined in the specification. The invention is also directed to compositions containing the compounds of Formula (I) as AMPA modulators. | 07-14-2011 |
20110178165 | TETRAHYDROFURANYL SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF - The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula (I): as defined in the specification. The invention is also directed to compositions containing the compounds of formula (I). They are useful in the treatment of CNS disorders. | 07-21-2011 |
20120202787 | Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I; | 08-09-2012 |
20120252758 | Novel Bicyclic Pyridinones - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 10-04-2012 |
20120295923 | Aminocyclohexanes and Aminotetrahydropyrans and Related Compounds As Gamma-Secretase Modulators - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 11-22-2012 |
20120322823 | HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF - The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: | 12-20-2012 |
20130129753 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF - The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer. | 05-23-2013 |
20140045790 | Novel Bicyclic Pyridinones - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 02-13-2014 |
20140088111 | Novel Bicyclic Pyridinones - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 03-27-2014 |
20140134193 | SPLICEOSTATIN ANALOGS AND METHODS FOR THEIR PREPARATION - The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer. | 05-15-2014 |
20140323502 | HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF - The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: | 10-30-2014 |
20140363452 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF - The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer. | 12-11-2014 |
20150072990 | Novel Pyrido[1,2-a]Pryazines And Their Use In The Treatment of Neurodegenerative and Neurological Disorders - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 03-12-2015 |
20150209445 | BIFUNCTIONAL CYTOTOXIC AGENTS - Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions. | 07-30-2015 |
20150307551 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF - The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer. | 10-29-2015 |
20160022626 | SPLICEOSTATIN ANALOGS AND METHODS FOR THEIR PREPARATION - The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer. | 01-28-2016 |
20160024088 | Novel Pyrido[1,2-a]Pryazines And Their Use in the Treatment of Neurodegenerative and Neurological Disorders - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 01-28-2016 |
Patent application number | Description | Published |
20100292716 | ATTACHABLE CLAMP FOR USE WITH SURGICAL INSTRUMENTS - An attachable clamp for use with a surgical instrument is disclosed. The attachable clamp comprises a body portion, a first jaw member, a second jaw member and an actuation mechanism. The body portion defines a longitudinal axis and has attachment members configured to attach to an elongate portion of a surgical instrument. Each of the first jaw member and second jaw member extends distally from the body portion. The actuation mechanism is disposed in mechanical cooperation with at least one of the first jaw member and the second jaw member. Actuation of the actuation mechanism moves at least one of the first and second jaw members between an approximated position and an open position with respect to the other jaw member. | 11-18-2010 |
20110068147 | SURGICAL INSTRUMENT WITH SEQUENTIAL CLAMPING AND CUTTING - A surgical fastening instrument including a handle portion, an elongated portion, an end effector and a clamp is disclosed. The elongated portion extends distally from the handle portion. The end effector includes a pair of jaws having a tissue contacting surface disposed substantially transverse to the longitudinal axis of the elongated portion. The end effector is disposed adjacent a distal end of the elongated portion, and at least one of the jaw members is movable with respect to the other between an open position and an approximated position for engaging body tissue therebetween. The clamp has a clamping surface extending substantially transversely from an elongated member and has a height exceeding a height of the elongated member to extend adjacent a side surface of the jaw containing the plurality of fasteners. The clamp is movable from a proximal position to a distal position for engaging body tissue. | 03-24-2011 |
20130317530 | ATTACHABLE CLAMP FOR USE WITH SURGICAL INSTRUMENTS - An attachable clamp for use with a surgical instrument is disclosed. The attachable clamp comprises a body portion, a first jaw member, a second jaw member and an actuation mechanism. The body portion defines a longitudinal axis and has attachment members configured to attach to an elongate portion of a surgical instrument. Each of the first jaw member and second jaw member extends distally from the body portion. The actuation mechanism is disposed in mechanical cooperation with at least one of the first jaw member and the second jaw member. Actuation of the actuation mechanism moves at least one of the first and second jaw members between an approximated position and an open position with respect to the other jaw member. | 11-28-2013 |
20140239048 | SURGICAL INSTRUMENT WITH SEQUENTIAL CLAMPING AND CUTTING - A surgical fastening instrument including a handle portion, an elongated portion, an end effector and a clamp is disclosed. The elongated portion extends distally from the handle portion. The end effector includes a pair of jaws having a tissue contacting surface disposed substantially transverse to the longitudinal axis of the elongated portion. The end effector is disposed adjacent a distal end of the elongated portion, and at least one of the jaw members is movable with respect to the other between an open position and an approximated position for engaging body tissue therebetween. The clamp has a clamping surface extending substantially transversely from an elongated member and has a height exceeding a height of the elongated member to extend adjacent a side surface of the jaw containing the plurality of fasteners. The clamp is movable from a proximal position to a distal position for engaging body tissue. | 08-28-2014 |
20150097017 | SURGICAL INSTRUMENT WITH SEQUENTIAL CLAMPING AND CUTTING - A surgical fastening instrument including a handle portion, an elongated portion, an end effector and a clamp is disclosed. The elongated portion extends distally from the handle portion. The end effector includes a pair of jaws having a tissue contacting surface disposed substantially transverse to the longitudinal axis of the elongated portion. The end effector is disposed adjacent a distal end of the elongated portion, and at least one of the jaw members is movable with respect to the other between an open position and an approximated position for engaging body tissue therebetween. The clamp has a clamping surface extending substantially transversely from an elongated member and has a height exceeding a height of the elongated member to extend adjacent a side surface of the jaw containing the plurality of fasteners. The clamp is movable from a proximal position to a distal position for engaging body tissue. | 04-09-2015 |
Patent application number | Description | Published |
20080270323 | System, Method, and Computer Program Product for Providing Stabilized Annuity Payments and Control of Investments in a Variable Annuity Patent Application - A system, method, and computer program product for providing stabilized annuity payments and control of investments in a variable annuity, the system comprising a processor, a memory, and a computer program stored in the memory. The computer program allocates the short and long term risks associated with an investment to the potential beneficiaries of the annuitant by controlling the allocation of assets between two investment pools. The annuitant pool is the pool on which annuity payments are based and the beneficiary pool contains assets that are provided to the beneficiaries upon the death of the annuitant. The beneficiary pool is used as a cushion to isolate the contents of the annuitant pool from fluctuations in value. The beneficiary pool is initially funded with sufficient assets to minimize the likelihood of its depletion under fairly conservative estimates of market conditions. If the underlying investments perform poorly, assets from the beneficiary pool are reallocated to the annuity pool in order to maintain the existing annuity payment. Thus, for as long as the beneficiary pool is not depleted, the annuity payment is stabilized and will not decrease. If the underlying investments perform favorably, increasing in value, excess amounts above a set trigger level amount will be periodically transferred to the annuitant pool. As these gains are transferred to the annuity pool, the annuity payment amounts will be increased accordingly. | 10-30-2008 |
20100185560 | System, Method, and Computer Program Product for Allocating Assets Among a Plurality of Investments to Guarantee a Predetermined Value at the End of a Predetermined Period - A system, method, and computer program product for allocating assets among a plurality of investments to guarantee a predetermined value at the end of a predetermined time period. A computer program controls the allocation of assets in the investment vehicle, which allows the investor to initially invest one hundred percent of the initial deposit in non-secure, high risk investments. At the end of the each trading day, the computer program determines if assets should be reallocated from the non-secure investments to the secure investments, from the secure investments to the non-secure investments, or if no reallocation is necessary. | 07-22-2010 |
20100318473 | System, Method, and Computer Program Product for Cost Effective, Dynamic Allocation of Assets Among a Plurality of Investments - A system, method, and computer program product for dynamic, cost effective reallocation of assets among a plurality of investment products comprising a processor, a memory and a computer program stored in the memory. The computer program implementing the present invention controls the reallocation of assets to reduce the transactions costs associated with rebalancing the investor's composite assets according to a composite asset allocation model. Information relating to the composite asset allocation model, the investor's assets, and the investor are stored in memory. Periodically, or upon occurrence of an event, the composite assets are evaluated to determine if rebalancing is necessary. If rebalancing is necessary, the transaction costs associated with the available transactions for performing the rebalancing are compared to select the most economically favorable transaction. Thus, the reallocation is achieved by selecting the least costly transaction that will serve to realize the composite asset allocation model, which is independent of the structure of the investor's portfolio among particular accounts or products. In addition, the computer program compares the available options for recovery of the transaction fees to select the most economically favorable means of recovering the fees associated with the transaction to further reduce the transaction cost of the reallocations. | 12-16-2010 |
20120284205 | SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR ALLOCATING ASSETS AMONG A PLURALITY OF INVESTMENTS TO GUARANTEE A PREDETERMINED VALUE AT THE END OF A PREDETERMINED PERIOD - A system, method, and computer program product for allocating assets among a plurality of investments to guarantee a predetermined value at the end of a predetermined time period. A computer program controls the allocation of assets in the investment vehicle, which allows the investor to initially invest one hundred percent of the initial deposit in non-secure, high risk investments. At the end of the each trading day, the computer program determines if assets should be reallocated from the non-secure investments to the secure investments, from the secure investments to the non-secure investments, or if no reallocation is necessary. | 11-08-2012 |