Patent application number | Description | Published |
20100035845 | TIGECYCLINE FORMULATIONS - The invention is directed to a frozen pharmaceutical formulation suitable for administration to a subject parenterally, comprising a therapeutically effective amount of tigecycline and an agent selected from the group consisting of lactose, dextrose, glucose, mannose, sucrose, ribose, xylose and a combination thereof, wherein the formulation in a pre-frozen state at about 22° C. or in an unfrozen state at about 22° C. has a pH in the range of from 4.0 to 5.5. Preferably, the formulation is suitable for storage at or below about −20° C. over a period of at least about 2 months, preferably 6 months, more preferably 26 months. Alternatively, the formulation is suitable for storage at about 22° C. over a period of about 24 hours. | 02-11-2010 |
20100249169 | FORMULATIONS FOR PARENTERAL DELIVERY OF COMPOUNDS AND USES THEREOF - The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids. | 09-30-2010 |
20120277197 | TIGECYCLINE FORMULATIONS - The invention is directed to a frozen pharmaceutical formulation suitable for administration to a subject parenterally, comprising a therapeutically effective amount of tigecycline and an agent selected from the group consisting of lactose, dextrose, glucose, mannose, sucrose, ribose, xylose and a combination thereof, wherein the formulation in a pre-frozen state at about 22° C. or in an unfrozen state at about 22° C. has a pH in the range of from 4.0 to 5.5. Preferably, the formulation is suitable for storage at or below about −20° C. over a period of at least about 2 months, preferably 6 months, more preferably 26 months. Alternatively, the formulation is suitable for storage at about 22° C. over a period of about 24 hours. | 11-01-2012 |
20150025100 | FORMULATIONS FOR PARENTERAL DELIVERY OF COMPOUNDS AND USES THEREOF - The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids. | 01-22-2015 |
Patent application number | Description | Published |
20120123402 | Method and Apparatus for Vascular Tissue Sealing with Reduced Energy Consumption - An end effector assembly for use with an electrosurgical instrument is provided. The end effector assembly includes a pair of opposing jaw members configured to grasp tissue therebetween. Each of the opposing jaw members includes a non conducting tissue contact surface and an energy delivering element configured to perforate the tissue to create an opening, extract elastin and collagen from the tissue and denaturize the elastin and the collagen in the vicinity of the opening. | 05-17-2012 |
20120123413 | Method and Apparatus for Vascular Tissue Sealing with Active Cooling of Jaws at the End of the Sealing Cycle - An end effector assembly for use with an electrosurgical instrument is provided. The end effector assembly has a first jaw member and a second jaw member. The second jaw member includes a channel defined therein and coupled to a cooling agent source and at least one venting port defined therein and fluidly coupled to the channel. During active cooling of the second jaw member, the cooling agent source is configured to supply a cooling agent to the channel. | 05-17-2012 |
20120226272 | System and Methods for Identifying Tissue and Vessels - A surgical system and corresponding methods for identifying tissue or vessels and assessing their conditions includes a probing signal source for applying a probing signal to the tissue and a response signal monitor for monitoring a response signal that varies according to the level of blood circulation in the tissue or vessels. The response signal monitor monitors the response signal over an interval equal to or longer than an interval between two successive cardiac contractions. The surgical system includes a microprocessor that analyzes the amplitude and/or phase of the response signal to determine the level of blood circulation in the tissue or in different portions of the tissue, and determines a tissue parameter based upon the level of blood circulation. The surgical system may monitor a cardiac signal related to cardiac contractions and correlate the response signal and the cardiac signal to determine a level of blood circulation in the tissue. | 09-06-2012 |
20120296205 | Optical Recognition of Tissue and Vessels - Methods and apparatus for optically recognizing tissue parameters during an energy-based tissue-sealing procedure involve grasping tissue with a tissue-sealing instrument, illuminating the grasped tissue or tissue adjacent to the grasped tissue with light, analyzing the light that is transmitted, scattered, or reflected by the tissue, and recognizing the tissue based on the result of analyzing the light. The wavelength of the light may be selected so that a vessel is sufficiently recognizable in tissue containing the vessel. A marker may also be introduced into fluid flowing in the vessel to increase the contrast between the vessel and tissue containing the vessel. Analyzing the light includes analyzing the spatial and spectral distribution of light. Analyzing the light may also include forming the light into an image of the illuminated tissue. The image of the illuminated tissue may be projected onto the eyes of a surgeon or sensed by a matrix of light detectors disposed on a jaw member of the tissue-sealing instrument and transmitted to a display. | 11-22-2012 |
20120296238 | System and Methods for Energy-Based Sealing of Tissue with Optical Feedback - An energy-based tissue-sealing system and method provide higher sealing quality by measuring and using optical feedback parameters that are directly correlated to structural changes of tissue. The tissue-sealing system includes a sealing energy source, an instrument having a mechanism for grasping and deforming the tissue and for delivering sealing energy to the tissue, a light source, optical sensors, and a controller for controlling parameters of the sealing energy generated by the sealing energy source based upon the optical parameters of the tissue structure sensed by the optical sensors. At the beginning of a sealing procedure, the controller may monitor an initial optical parameter of the tissue and select a target trajectory of tissue optical parameters based on the initial optical parameter. During the sealing procedure, the controller monitors at least one optical parameter of the tissue structure and controls at least one parameter of the sealing energy based on the at least one optical parameter. | 11-22-2012 |
20120296239 | Destruction of Vessel Walls for Energy-Based Vessel Sealing Enhancement - An end effector assembly for use with an electrosurgical instrument is provided. The end effector assembly includes a pair of opposing jaw members configured to grasp tissue therebetween, at least one jaw member adapted to connect to a source of electrosurgical energy to seal tissue disposed between jaw members during a sealing process. At least one of the jaw members includes an activator configured to selectively impart mechanical perturbations to the at least one jaw member during the sealing process. | 11-22-2012 |
20120296317 | Optical Energy-Based Methods and Apparatus for Tissue Sealing - Optical energy-based methods and apparatus for sealing vascular tissue involves deforming vascular tissue to bring different layers of the vascular tissue into contact each other and illuminating the vascular tissue with a light beam having at least one portion of its spectrum overlapping with the absorption spectrum of the vascular tissue. The apparatus may include two deforming members configured to deform the vascular tissue placed between the deforming members. The apparatus may also include an optical system that has a light source configured to generate light, a light distribution element configured to distribute the light across the vascular tissue, and a light guide configured to guide the light from the light source to the light distribution element. The apparatus may further include a cutting member configured to cut the vascular tissue and to illuminate the vascular tissue with light to seal at least one cut surface of the vascular tissue. | 11-22-2012 |
20120296323 | Optical Energy-Based Methods and Apparatus for Tissue Sealing - Optical energy-based methods and apparatus for sealing vascular tissue involves deforming vascular tissue to bring different layers of the vascular tissue into contact each other and illuminating the vascular tissue with a light beam having at least one portion of its spectrum overlapping with the absorption spectrum of the vascular tissue. The apparatus may include two deforming members configured to deform the vascular tissue placed between the deforming members. The apparatus may also include an optical system that has a light source configured to generate light, a light distribution element configured to distribute the light across the vascular tissue, and a light guide configured to guide the light from the light source to the light distribution element. The apparatus may further include a cutting member configured to cut the vascular tissue and to illuminate the vascular tissue with light to seal at least one cut surface of the vascular tissue. | 11-22-2012 |
20120296324 | Optical Energy-Based Methods and Apparatus for Tissue Sealing - Optical energy-based methods and apparatus for sealing vascular tissue involves deforming vascular tissue to bring different layers of the vascular tissue into contact each other and illuminating the vascular tissue with a light beam having at least one portion of its spectrum overlapping with the absorption spectrum of the vascular tissue. The apparatus may include two deforming members configured to deform the vascular tissue placed between the deforming members. The apparatus may also include an optical system that has a light source configured to generate light, a light distribution element configured to distribute the light across the vascular tissue, and a light guide configured to guide the light from the light source to the light distribution element. The apparatus may further include a cutting member configured to cut the vascular tissue and to illuminate the vascular tissue with light to seal at least one cut surface of the vascular tissue. | 11-22-2012 |
20120296332 | Thread-Like Knife for Tissue Cutting - An end effector assembly for use with an electrosurgical instrument is provided. The end effector assembly includes a pair of opposing jaw members configured to grasp tissue therebetween. The assembly also includes a thread-like member having a first end coupled to at least one jaw member and a drive member coupled to a second end of the thread-like member. The drive member is configured to position the thread-like member between a first position and a second position, wherein the thread-like member cuts tissue when positioned in the second position. | 11-22-2012 |
20130018364 | Stand Alone Energy-Based Tissue ClipsAANM Misuchenko; IgorisAACI Saint-PetersburgAACO RUAAGP Misuchenko; Igoris Saint-Petersburg RUAANM Martsinovskiy; GeorgyAACI Saint-PetersburgAACO RUAAGP Martsinovskiy; Georgy Saint-Petersburg RUAANM Verbitsky; MikhailAACI StougtonAAST MAAACO USAAGP Verbitsky; Mikhail Stougton MA USAANM Chernova; NataliyaAACI Saint-PetersburgAACO RUAAGP Chernova; Nataliya Saint-Petersburg RU - The present disclosure is directed to a tissue clip for use in electrosurgical procedures. The tissue clip includes an arm having a first electrode formed thereon. The tissue clip also includes a body pivotally coupled to the arm. The body includes a power source and a second electrode. The arm is moveable from a first position relative to the body for approximating tissue and a second position closer to the body for grasping tissue therebetween | 01-17-2013 |
Patent application number | Description | Published |
20140377667 | Lithium-2-Methoxy-1,1,2,2-Tetrafluoro-Ethanesulfonate and Use Thereof as Conductive Salt in Lithium-Based Energy Accumulators - The invention relates to lithium-2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate, to the use thereof as conductive salt in lithium-based energy accumulators, and ionic liquids comprising 2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate as an anion. | 12-25-2014 |
20150044573 | ELECTROLYTE SALT FOR LITHIUM-BASED ENERGY STORES - The invention relates to lithium 1-trifluoromethoxy-1,2,2,2-tetra-fluoroethanesulphonate, the use of lithium 1-trifluoromethoxy-1,2,2,2-tetra-fluoroethanesulphonate as electrolyte salt in lithium-based energy stores and also ionic liquids comprising 1-trifluoro-methoxy-1,2,2,2-tetrafluoro-ethanesulphonate as anion. | 02-12-2015 |
20150099165 | ELECTROLYTE ADDITIVE FOR A LITHIUM-BASED ENERGY STORAGE DEVICE - The invention relates to an electrolyte for a lithium-based energy storage device comprising at least one lithium salt, a solvent and at least one compound of general formula (1), and to their use in lithium-based energy storage devices. | 04-09-2015 |
20150188191 | 1,2,4-THIADIAZINANE-3,5-DIONE-1,1-DIOXIDE DERIVATIVES, PRODUCTION AND USE THEREOF - The present invention provides a compound with a general formula (I) | 07-02-2015 |
Patent application number | Description | Published |
20090282463 | EFFICIENT ATTACHMENT OF USER-SELECTED FILES TO E-MAIL FROM HANDHELD DEVICE - A wireless telecommunications system includes facilities in a wireless hand-held device (WHHD) that allows a user to browse files available to that user on storage devices in an enterprise network, and to identify one or more such files to be attached to an e-mail message to be composed on or transmitted from the handheld. The system includes facilities in an enterprise network, such as a file delivery server, that cooperates with the WHHD to provide the file browsing service. A mail agent cooperates with the WHHD, responsive to instruction from the handheld to send an e-mail message that is to contain an attachment, to request the file delivery server to retrieve the identified files and assemble an e-mail containing those files as attachments. The WHHD may receive from the user appropriate credentials needed to access files available to that user on storage devices in the enterprise network, and may forward the credential to the file delivery server and the mail agent. These components may use the credentials to provide the file browsing service and to retrieve the identified files. | 11-12-2009 |
20100069068 | System And Methods For Data Communications In A Wireless Communication System - In one embodiment, a mobile communication device is configured to selectively enable user data communications after registration in a wireless communication network. The mobile device sends, via its radio, feature compliance information to the network. In response to the feature compliance information being sent, the mobile device receives, via the radio, configuration information which is derived based on the feature compliance information and location information of the mobile device. The mobile device then selectively enables the user data communications based on the received configuration information. In particular, the mobile device enables the user data communications when the location information indicates that the mobile device is operating in a particular country and the feature compliance information indicates feature compliance for the particular country. On the other hand, the mobile device disables the user data communications when the location information indicates that the mobile device is operating in the particular country and the feature compliance information indicates a lack of feature compliance for the particular country. | 03-18-2010 |
20100241480 | System and Method for Dynamic Manipulation of Data Describing User Availability - In one embodiment, a scheme is disclosed for processing data in relation to a user's availability. The data relates to one or more time slots identified as available or unavailable, each time slot having a start time and an end time as well as an availability status indicator. The scheme involves determining an earliest of start times and a latest of end times associated with the time slots, and storing only the earliest of start times and latest of end times for the user so as to condense the availability information on a user-by-user basis. | 09-23-2010 |
20110076997 | System And Methods For Data Communications In A Wireless Communication System - In one embodiment, a method of operating a mobile device comprises receiving an enable message at the mobile device, the enable message being indicative of a pending message to be retrieved; opening an application at the mobile device subsequent to the receiving of the enable message; and sending a fetch message to retrieve the pending message, the sending occurring pursuant to the opening of the application. | 03-31-2011 |
20120071136 | System And Methods For Data Communications In A Wireless Communication System - In one illustrative example, a mobile device receives from a relay services node an enable message which indicates a pending data message to be retrieved from a host service. The pending data message may comprise a body of text. Subsequent to the receiving of the enable message, a messaging application is opened at the mobile device. In response to the opening of the messaging application, the mobile device communicates directly with the host service without use of the relay services node, for retrieving the pending data message from the host service via a wireless network. | 03-22-2012 |
20120083247 | System And Methods For Wireless Messaging - A mobile device receives via a wireless network an enable message which indicates that a data message has been received and is ready for retrieval. The mobile device then provides an indication which indicates that the data message has been received, and includes a subset of the data message. After providing the indication, the mobile device detects a user-initiated entry into a messaging application. In response to detecting the user-initiated entry, the mobile device examines a setting in a data store which is provided in response to the enable message. If the setting is provided in the data store, the mobile device requests the data message by sending via the wireless network a fetch message and subsequently receives the data message. If the setting is not provided in the data store, the mobile device refrains from sending the fetch message. | 04-05-2012 |
20130065560 | System And Methods For Data Communications In A Wireless Communication System - Techniques for use by a mobile device configured to operate in a wireless network for the communication of data messages with a server are described. When the mobile device does not have an open session with the server, the mobile device receives from a service node via the wireless network a message which informs the mobile device that a data message has arrived at the server and needs to be retrieved. The message includes an identifier which identifies the data message at the server. In response to opening an application at the mobile device, the mobile device communicates directly with the server via the wireless network for retrieving the data message. This involves commencing an open session with the server, sending to the server a command for retrieving the data message, and receiving from the server the data message in response to sending the command. The mobile device may use the identifier for retrieving the data message from the server. | 03-14-2013 |
20130107814 | SYSTEM AND METHODS FOR WIRELESS MESSAGING | 05-02-2013 |
20140199997 | SYSTEM AND METHODS FOR DATA COMMUNICATIONS IN A WIRELESS COMMUNICATION SYSTEM - Techniques for use by a mobile device configured to operate in a wireless network for the communication of data messages with a server are described. When the mobile device does not have an open session with the server, the mobile device receives from a service node via the wireless network a message which informs the mobile device that a data message has arrived at the server and needs to be retrieved. The message includes an identifier which identifies the data message at the server. In response to opening an application at the mobile device, the mobile device communicates directly with the server via the wireless network for retrieving the data message. This involves commencing an open session with the server, sending to the server a command for retrieving the data message, and receiving from the server the data message in response to sending the command. The mobile device may use the identifier for retrieving the data message from the server. | 07-17-2014 |
Patent application number | Description | Published |
20090278086 | Nanocrystalline Composite for Storage of Hydrogen - The invention relates to a method for preparation of a material adapted to reversible storage of hydrogen, including steps consisting of providing a first powder of a magnesium-based material, hydrogenating the first powder to convert at least part of the first powder into metal hydrides, mixing the first hydrogenating powder with a second powder additive, the proportion by mass of the second powder in the mix obtained being between 1% and 20% by mass, wherein the additive is formed from an alloy with a centred cubic structure based on titatnium, vanadium and at least one other metal chosen from chromium or manganese, and grinding the mix of first and second powders. | 11-12-2009 |
20130111736 | METHOD FOR PREPARING A MATERIAL FOR STORING HYDROGEN, INCLUDING AN EXTREME PLASTIC DEFORMATION OPERATION - A material for storing hydrogen is prepared by a method including an extreme plastic deformation operation selected from cold-rolling, quick-forging and extrusion-bending performed on a metallic material selected from among a metal and an alloy containing said metal, or on a compound containing a metal material selected from among a metal and an alloy containing said metal and to which a hydride of said metal or a hydride of said alloy has been added. When the extreme plastic deformation operation is carried out on the metallic material, it is followed by an operation of adding, to the metal material, a hydride of said metal or a hydride of said alloy, as well as by a dispersing operation. | 05-09-2013 |
Patent application number | Description | Published |
20080213907 | Protein markers for the diagnosis and prognosis of ovarian and breast cancer - Plasma samples of ovarian and breast cancer patients were used to search for markers of cancer, using two-dimensional gel electrophoresis and MALDI TOF mass spectrometry. Truncated forms of cytosolic serine hydroxymethyl transferase (cSHMT), T-box transcription factor 3 (Tbx3) and utrophin were aberrantly expressed in samples from cancer patients, as compared to samples from noncancer cases. Aberrant expression of proteins was validated by immunoblotting of plasma samples with specific antibodies to cSHMT, Tbx3 and utrophin. A cohort of 79 breast and 39 ovarian cancer patients, and 31 individuals who were either healthy or had noncancerous conditions was studied. We observed increased expression of truncated cSHMT, Tbx3 and utrophin in plasma samples obtained from patients at early stages of disease. The results indicate that cSHMT, Tbx3, utrophin and truncated forms thereof can be used as components of multiparameter monitoring of ovarian and breast cancer. | 09-04-2008 |
20120238478 | PROTEIN MARKERS FOR THE DIAGNOSIS AND PROGNOSIS OF OVARIAN AND BREAST CANCER - Plasma samples of ovarian and breast cancer patients were used to search for markers of cancer, using two-dimensional gel electrophoresis and MALDI TOF mass spectrometry. Truncated forms of cytosolic serine hydroxymethyl transferase (cSHMT), T-box transcription factor 3 (Tbx3) and utrophin were aberrantly expressed in samples from cancer patients, as compared to samples from noncancer cases. Aberrant expression of proteins was validated by immunoblotting of plasma samples with specific antibodies to cSHMT, Tbx3 and utrophin. A cohort of 79 breast and 39 ovarian cancer patients, and 31 individuals who were either healthy or had noncancerous conditions was studied. We observed increased expression of truncated cSHMT, Tbx3 and utrophin in plasma samples obtained from patients at early stages of disease. The results indicate that cSHMT, Tbx3, utrophin and truncated forms thereof can be used as components of multiparameter monitoring of ovarian and breast cancer. | 09-20-2012 |