Morgans
David Morgans, Mill Valley, CA US
Patent application number | Description | Published |
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20140327158 | METHOD FOR IDENTIFYING MODULATORS OF UBIQUITIN LIGASES - The present invention provides a screen which exploits mechanism-based activity probes that specifically and covalently modify the active site cysteine thiol residue of E3 Ub ligases including, but not limited to the HECT and RBR family. The activity probes are used to screen for activators and inhibitors of E3 Ub ligases, and to interrogate the functional state of E3 Ub ligases in human disease. | 11-06-2014 |
David J. Morgans, South San Francisco, CA US
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20080255182 | Certain chemical entities, compositions, and methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 10-16-2008 |
David J. Morgans, Los Altos, CA US
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20080242695 | Certain Chemical Entities, Compositions, and Methods - Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of muscle weakness and/or cachexia, as part of a rehabilitation or conditioning exercise regimen, or in the treatment of fraility, post-polio syndrome, obesity, sarcopenia, wasting syndrome, muscle spasm, and other indications. | 10-02-2008 |
20130296335 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS - Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure. | 11-07-2013 |
20130324549 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS - Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure. | 12-05-2013 |
20140038983 | UREAS AND THEIR USE IN THE TREATMENT OF HEART FAILURE - Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure. | 02-06-2014 |
Nathan Morgans, Jacksonville, FL US
Patent application number | Description | Published |
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20100208485 | Modular EL wire bicycle and vehicle kit - A modular electroluminescent lighting kit to apply to a bicycle, car, or other vehicle for increased safety, visibility and design style. The kit is comprised of a battery driver which can be further powered by solar or kinetic devices, an EL wire or other illuminated filament configuration that conforms to the frame of the bicycle or form of the vehicle interior/exterior taking into account the areas of said vehicles that have moving parts. The kit includes basic or custom brackets to affix the wires in place in any design configuration that pleases the end user. The kit may be designed to be upgradable in modular stages and including but not limited to LED devices, motion sensing stand-alone wheel lighting, or plastic molded mountable lighting devices. | 08-19-2010 |
Richard Christie Morgans, Kilburn AU
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20110153282 | Method of designing a sound waveguide surface - A method for designing a sound waveguide surface is described. The method includes the steps of forming a parametric model of the sound waveguide surface where the parametric model has at least one input parameter and then simulating a sound field that is formed by the sound waveguide surface. A frequency dependent spatial distribution measure is then determined for the sound field associated with the sound waveguide surface and the at least one input parameter is varied to change the sound waveguide surface to adjust the value of the frequency dependent spatial distribution measure. | 06-23-2011 |
Scott Richard Morgans, Encinitas, CA US
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20140259253 | APPARATUSES, SYSTEMS AND METHODS FOR PROVIDING PROTECTION AGAINST HAZARDS - An apparatus for protecting the face, head, and neck of a user against hazards including an eye protector with a lower area and an upper area for protecting the eye area of a user from hazards and a face protector having at least one fastener for removably attaching the upper edge area of the face protector to the lower edge area of an eye protector. The fastener sealably fastens the area between the face protector and the eye protector so that the face area and the eye area are protected from hazards. Other configurations may be used to protect other areas of the user's body and the fasteners may be magnetic, hook and look or any other suitable type of fastener. The eye protector may also be configured with a removeably attachable lens and the one or more removably attachable light emitters positioned on the outwardly facing surface of said face protector may also be used. Systems and methods of using the apparatus are also disclosed. | 09-18-2014 |
Shawn Morgans, Chelsea, MI US
Patent application number | Description | Published |
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20110274483 | BOLTED JOINT ASSEMBLY - A bolted joint assembly is described. The joint assembly includes a tubular reinforcement member for adding strength to the anchor assembly. The member having an aperture punched through-and-through the member substantially perpendicular to the longitudinal axis of the member. The anchor assembly further includes a hollow spacer tube extending through the aperture, the spacer diameter being substantially equal to the aperture diameter. Moreover, the assembly includes a bolt with a bolt head extended through the spacer. The bolt diameter is substantially equal to the spacer diameter. A nut threadably receives the anchor bolt. | 11-10-2011 |
Shawn Michael Morgans, Chelsea, MI US
Patent application number | Description | Published |
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20100314911 | Vehicle Roof Reinforcement Feature - A vehicle body structure comprises body side panels each comprising a roof mounting surface, a roof panel having opposing sides, and a brazed joint attaching the roof panel to the body side panels along a line of contact. The roof panel comprises a raised bead portion on each side of a central portion, character lines having sloped surfaces extending downward from each raised bead portion to the central portion, and a side mounting flange at each side of the roof panel that curls under the raised bead portions. Each side mounting flange has a line of contact with a corresponding roof mounting surface. | 12-16-2010 |
20110093105 | COMPUTERIZED SYSTEM AND METHOD FOR RECOMMENDING PART MATERIALS - A computer-implemented method for recommending one or more materials used in designing and manufacturing parts may include receiving data from at least three data sources. The data sources may include a sourcing, manufacturing, and design data source. The data source data may be standardized to obtain a collection of data including a dataset of materials for consideration in recommending one or more materials for use in one or more parts. The method may also include receiving optimization metrics and constraints for the dataset of materials. Optimization values for each material based on the dataset of materials and the one or more optimization metrics may be determined. An optimization algorithm on each material may be performed based at least on the optimization values and the constraints to obtain one or more recommended materials from the dataset of materials for use in a design of one or more parts. | 04-21-2011 |
20110093107 | Computer-Implemented Method and System for Determining a Material Utilization for Part Assemblies - Various embodiments may include determining a material utilization for one or more assemblies having a plurality of parts. Offal data for one or more parts comprising one or more part assemblies and a blank material utilization status for each of the one or more part assemblies may be received. The blank material utilization status for the one or more part assemblies may be based on a blank material utilization status for each of the one or more parts. The offal data may be standardized to obtain standardized offal data. One or more offal utilization assignments for the part assemblies having a plurality of parts may be determined based on the standardized offal data and the blank material utilization status for the part assemblies. The offal utilization assignments may then be transmitted for assignment to the one or more part assemblies. | 04-21-2011 |
20110172794 | COMPUTERIZED METHOD AND SYSTEM FOR SELECTING TECHNOLOGY USED IN VEHICLE PRODUCTION - Various embodiments may include a computerized system and method for determining a selection of technologies or processes for use in part production. A dataset of technologies or processes may be considered and standardized. Generic CAD models may be generated from the standardized dataset. Optimization metrics for each generic CAD model may be received. Data from a sourcing, a manufacturing and a design data source may also be received. An optimization algorithm may be used for each generic CAD model based on the optimization metrics and the data from the data sources. One or more optimized CAD models may be generated and one or more optimized technologies or processes for use in part manufacturing may be obtained. The optimized technologies or processes may be based on the one or more optimized CAD models. The optimized technologies or processes may be transmitted for selection and use in producing manufactured parts. | 07-14-2011 |
20140123495 | BONDING OF ROOF PANELS - A method for attaching a roof panel to a roof rail of a vehicle bodyside frame, wherein the roof rail prohibiting access to an underside of an area at which the roof panel attaches to the roof panel, can include applying a single-component adhesive to a roof rail or to a portion of a roof panel that rests on the roof rail, placing the roof panel onto the roof rail, attaching the roof panel to the roof rail using single-sided spot welds, and heating the roof panel and vehicle bodyside frame to a temperature that cures the single-component adhesive. | 05-08-2014 |