Mohile
Ajey Avinash Mohile, West Bloomfield, MI US
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20120191311 | METHOD AND APPARATUS FOR AIDING A DRIVER TO PARK A VEHICLE - In order to avoid a sudden jerk when a vehicle is parked on a slope and its parking pawl engages with a toothed wheel on the transmission output shaft, a method is performed that detects that the vehicle's gear selector has been put into its parking mode and then gradually reduces the brake force until the vehicle starts moving. If the vehicle stops, the brake force will slowly be further reduced until the vehicle has reached its final position. | 07-26-2012 |
Swapnil Surendra Mohile, Pune IN
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20150344919 | PROCESS FOR THE PREPARATION OF PREGABALIN - The present invention provides an improved process for the preparation of a compound of formula (I), which comprises the steps of: formula (I), (a) reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) optionally in presence of salts of weak acid and weak base or weak base in a suitable solvent to get 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV); (b) reacting 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV) with a suitable cyanide source in water or in an organic solvent or mixture thereof to get 2-isobutylsuccinonitrile of formula (V); (c) obtaining optionally 2-isobutylsuccinonitrile of formula (V) by reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) in presence of suitable cyanide source in water or in an organic solvent or mixture thereof in single step; (d) converting 2-isobutylsuccinonitrile of formula pa (V) to racemic 3-cyano-5-methyl-hexanoic acid or salt thereof of formula (VI) with a genetically modified nitrilase enzyme (Nit pt 9N_56_2) in water or optionally with an organic co-solvent at appropriate pH and temperature; (e) converting racemic 3-cyano-5-methyl-hexanoic acid or salt thereof of formula (VI) to racemic alkyl 3-cyano-5-methyl-hexanoate of formula (VII) by treatment with alcohol (R3OH) and acidic catalyst or alkyl halide (R3X) in presence of a base in a suitable solvent or a mixture of solvents thereof; (f) obtaining (S)-alkyl 3-cyano-5-methyl-hexanoate of formula (VIII) and (R)-3-cyano-5-methyl-hexanoic acid or salt thereof of formula (X) by enzymatic enantioselective hydrolysis in water or organic solvent or a mixture thereof from racemic alkyl 3-cyano-5-methyl-hexanoate of formula (VII); (g) obtaining optionally the compound of formula (VII) by racemizing unwanted (R)-3-cyano-5-methyl-hexanoic acid or salt thereof of formula (X) or substantially enriched (R)-3-cyano-5-methyl-hexanoic acid salt thereof of formula (X) in presence of a base in organic solvent or a mixture thereof; (h) converting (S)-alkyl 3-cyano-5-methyl-hexanoate of formula (VIII) to pregabalin of formula (I) by hydrolyzing ester group with suitable alkali or alkaline earth metal base followed by hydrogenation optionally in one pot in a solvent selected from water or other organic solvents or a mixture thereof in presence of a suitable hydrogenation catalyst. | 12-03-2015 |
Vivek V. Mohile, West Bloomfield, MI US
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20150162145 | STEERING COLUMN CONTROL MODULE - A steering column control module comprises a housing having at least two receptacles. A printed circuit board is mounted in the housing, the printed circuit board carrying first and second electrical connectors. A third electrical connector is mounted in the housing remote from the printed circuit board. A ribbon cable is connected between the second and third electrical connectors. The receptacles are adapted to receive respective switch modules. The first and third electrical connectors are positioned and configures so that, when plugged into respective receptacles, the switch modules connect to respective ones of the first and third electrical connectors. | 06-11-2015 |