Mishkin, US
Allison Fine Mishkin, New York, NY US
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20140274254 | LITERATURE CARD GAME - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for a literature card game. In one aspect, a method includes receiving a request to view a book; displaying the book on a display device. The method further includes displaying an activity indicator at a location in the book. The method further includes receiving a selection of the activity indicator. The method further includes displaying an activity on the display device, the activity being associated with the book and the location of the activity indicator within the book. The method further includes receiving a response to the displayed activity from the user; determining that the response to the activity meets specified criteria. The method further includes awarding a playing card that is associated with the book, the playing card configured to be used in a card game played by the user. | 09-18-2014 |
Bernard Mishkin, Los Angeles, CA US
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20100065058 | Full face respirator mask - A full face respirator mask includes a rigid plastic integrally molded lens member that has a transparent viewing portion and a central integrally molded port portion. The central port portion is disposed beneath the viewing portion when the mask is viewed from a front elevation. An integrally molded exhalation port is disposed in the central port portion of the rigid plastic lens. First and second air intake ports are disposed in the integrally molded lens member to either side of the central port portion of the rigid plastic lens member. Each air intake port is adapted to support either a plug member to close off the air intake ports or a filter cartridge to filter air passing through the air intake port. An integrally molded portion forming a connector is located within the central port portion of the integrally molded lens member to receive either an outside supply of air when the air intake ports each hold a plug member to close off the air intake ports or a plug member to close off the connector when the air intake ports support the filter cartridges. A face seal is attached to the lens member at an outside edge of the lens member and is adapted to mate with the wearer's face, and the face seal is attached by overmolding the face seal around the outside edge of the lens member to form an adhesive bond between the face seal and the lens member. | 03-18-2010 |
20120030912 | Adjustable buckle for a respriator mask - An adjustable buckle located around a resilience strap for a respirator including a resilient strap material having a particular length, width and thickness. An adjustable buckle is molded around the strap at a particular position and formed of two interlocking members each located at an end position of the strap and having at least one portion that interlocks with a corresponding portion of the other member. This provide for locking and unlocking of the members with each other. At least one of the interlocking members includes a plurality of such portions that interlocks with the corresponding portion of the other member. The plurality of portions are spaced from each other along the length of the strap so that an individual one of the plurality of portions may be interlocked with the corresponding portion of the other member to adjust the length of the strap. | 02-09-2012 |
Bryan J. Mishkin, Bellevue, WA US
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20140298219 | Visual Selection and Grouping - Techniques for visual selection and grouping are described. In at least some embodiments, multiple visuals can be selected and grouped such that visuals can be manipulated as a group and various actions can be applied to visuals as a group. For example, in response to a user placing a group of visuals in a display region, the visuals can be arranged in the display region based on a specific arrangement order. According to one or more embodiments, visuals can be rearranged to reduce gaps between visuals, such as to present a consolidated view of visuals and to conserve display space. Visuals can be grouped together (e.g., based on user selection), and selectable options presented that are selectable to apply various actions to the grouped visuals. | 10-02-2014 |
Eric Mishkin, Winter Springs, FL US
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20090117581 | Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS) - The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. | 05-07-2009 |
20100159443 | DISEASE MODEL INCORPORATION INTO AN ARTIFICIAL IMMUNE SYSTEM (AIS) - The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising a three-dimensional matrix comprising lymphoid tissue, a three-dimensional matrix comprising epithelial and/or endothelial cells, and diseased cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. | 06-24-2010 |
20100166763 | METHOD FOR DETERMINING THE IMMUNOGENICITY OF AN ANTIGEN - The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. | 07-01-2010 |
20100184148 | IN VITRO GERMINAL CENTERS - The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days. | 07-22-2010 |
20100287630 | MODELS FOR VACCINE ASSESSMENT - The present invention is directed to methods for constructing and using in vivo and in vitro models of aspects of human immunity and, in particular, construction of a human immune system model for the testing of, for example, vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. The present invention comprises both in vivo and in vitro models of aspects of human immunity that are useful for assessing the interaction of substances with the immune system, and thus can be used to accelerate and improve the accuracy and predictability of, for example, vaccine, drug, biologic, immunotherapy, cosmetic and chemical development. The invention is also useful for the generation of human monoclonal and polyclonal antibodies. | 11-11-2010 |
20110250620 | METHODS OF EVALUATING AN IMMUNE RESPONSE TO AN ANTIGEN - The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days. | 10-13-2011 |
20110269176 | METHODS FOR ASSAYING RESPONSES TO VACCINES - The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days. | 11-03-2011 |
20140248640 | METHODS FOR TESTING AN IMMUNE RESPONSE USING CULTURES OF T CELLS, B CELLS, DENDRITIC CELLS AND FOLLICULAR DENDRITIC CELLS - The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. | 09-04-2014 |
Eric M. Mishkin, Winter Springs, FL US
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20090011455 | DISEASE MODEL INCORPORATION INTO AN ARTIFICIAL IMMUNE SYSTEM (AIS) - The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and other materials in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system, coupled with disease models to provide a more complete representation of an immune response. | 01-08-2009 |
20100279277 | METHODS OF EVALUATING A TEST AGENT IN A DISEASED CELL MODEL - The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and other materials in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system, coupled with disease models to provide a more complete representation of an immune response. | 11-04-2010 |
20120009561 | METHODS OF EVALUATING A TEST AGENT IN A DISEASED CELL MODEL - The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and other materials in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system, coupled with disease models to provide a more complete representation of an immune response. | 01-12-2012 |
Gary Mishkin, Potomac, MD US
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20110120930 | DOUBLE FIBER BUNDLE DIALYZER - A dialyzer composed of: first and second dialyzation chambers, and an intermediate chamber interposed between the first and second dialyzation chambers. Each dialyzation chamber has opposed first and second ends and contains a filter member that separates the chamber into a blood compartment and a dialysate compartment. Each of the compartments extends between first and second ends. Each of the chambers has a respective one of a blood inlet or outlet and a dialysate inlet or outlet arranged so that blood and dialysate flow in counter-current to one another in both chambers. The intermediate chamber is connected to form a dialysate-free blood flow passage between the blood compartments. | 05-26-2011 |
20140158605 | DOUBLE FIBER BUNDLE DIALYZER - A dialyzer composed of: first and second dialyzation chambers, and an intermediate chamber interposed between the first and second dialyzation chambers. Each dialyzation chamber has opposed first and second ends and contains a filter member that separates the chamber into a blood compartment and a dialysate compartment. Each of the compartments extends between first and second ends. Each of the chambers has a respective one of a blood inlet or outlet and a dialysate inlet or outlet arranged so that blood and dialysate flow in counter-current to one another in both chambers. The intermediate chamber is connected to form a dialysate-free blood flow passage between the blood compartments. | 06-12-2014 |
Gary Joel Mishkin, Potomac, MD US
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20090171261 | METHOD AND APPARATUS FOR CALCULATING FLUID FLOW RATE - A switch valve for use in an extracorporeal blood flow circuit comprises a valve housing having a chamber, four openings communicating with the chamber, and a valve member located in the valve chamber. A first opening is to be connected to a patient via an arterial cannula, a second opening is to be connected to a patient via an venous cannula, a third opening is to be connected to a first inlet/outlet of a blood treatment device, and a fourth opening is to be connected to a second inlet/outlet of a blood treatment device. The valve member is movable within the valve housing to fluidly connect the first opening to either the third or the fourth opening and to fluidly connect the second opening to either the third or the fourth opening. The width of the valve member is smaller than a peripheral dimension of the openings. | 07-02-2009 |
Gary Joel Mishkin, Gaithersburg, MD US
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20150115172 | APPLIANCE FOR DISINFECTING HAND-HELD DEVICES - An appliance for disinfecting hand-held devices each having a surface that is contacted manually when the device is in use, composed of: a source of disinfecting radiation; and a conveyer system operative to convey the devices past the source with the top and/or bottom surfaces of each device facing the source, wherein the conveyor system is composed of a plurality of hollow, transparent rollers; and the source of disinfecting radiation includes a plurality of lamps, each housed in a respective one of the trans parent rollers. | 04-30-2015 |
Gregory Evan Mishkin, Cumming, GA US
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20100261449 | Determining Telecommunication Subscriber Metrics - Information associated with a communication is gathered at a switching point during the routing process to determine subscriber metric information associated with an active service identifier. The information relates to the originator of the communication and the target. The information is compared to a provider database to determine a carrier originally associated with the active service identifier. The information is then compared to a porting database to determine if the active service identifier was ported, and if so, to which carrier the active service identifier was ported. A determination can then be made regarding which carrier is associated with the active service identifier. The data may be aggregated for a large amount of switched communications, representing a large amount of active service identifiers for a given market. Thus, a number of subscribers for a given carrier in a given market may be determined. | 10-14-2010 |
20120163225 | Determining Telecommunication Subscriber Metrics - Information associated with a communication is gathered at a switching point during the routing process to determine subscriber metric information associated with an active service identifier. The information relates to the originator of the communication and the target. The information is compared to a provider database to determine a carrier originally associated with the active service identifier. The information is then compared to a porting database to determine if the active service identifier was ported, and if so, to which carrier the active service identifier was ported. A determination can then be made regarding which carrier is associated with the active service identifier. Various systems and methods may be used to determine a number of subscribers, a number of new subscribers, and a number of disconnected subscribers for a given carrier in a given market. | 06-28-2012 |
20140235196 | DETERMINING TELECOMMUNICATION SUBSCRIBER METRICS - Information associated with a communication is gathered at a switching point during the routing process to determine subscriber metric information associated with an active service identifier. The information relates to the originator of the communication and the target. The information is compared to a provider database to determine a carrier originally associated with the active service identifier. The information is then compared to a porting database to determine if the active service identifier was ported, and if so, to which carrier the active service identifier was ported. A determination can then be made regarding which carrier is associated with the active service identifier. The data may be aggregated for a large amount of switched communications, representing a large amount of active service identifiers for a given market. Thus, a number of subscribers for a given carrier in a given market may be determined. | 08-21-2014 |
20140323080 | DETERMINING TELECOMMUNICATION SUBSCRIBER METRICS - Information associated with a communication is gathered at a switching point during the routing process to determine subscriber metric information associated with an active service identifier. The information relates to the originator of the communication and the target. The information is compared to a provider database to determine a carrier originally associated with the active service identifier. The information is then compared to a porting database to determine if the active service identifier was ported, and if so, to which carrier the active service identifier was ported. A determination can then be made regarding which carrier is associated with the active service identifier. Various systems and methods may be used to determine a number of subscribers, a number of new subscribers, and a number of disconnected subscribers for a given carrier in a given market. | 10-30-2014 |
20140370845 | DETERMINING TELECOMMUNICATION SUBSCRIBER METRICS - Information associated with a communication is gathered at a switching point during the routing process to determine subscriber metric information associated with an active service identifier. The information relates to the originator of the communication and the target. The information is compared to a provider database to determine a carrier originally associated with the active service identifier. The information is then compared to a porting database to determine if the active service identifier was ported, and if so, to which carrier the active service identifier was ported. A determination can then be made regarding which carrier is associated with the active service identifier. The data may be aggregated for a large amount of switched communications, representing a large amount of active service identifiers for a given market. Thus, a number of subscribers for a given carrier in a given market may be determined. | 12-18-2014 |
Martin Alfred Mishkin, Loveland, OH US
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20100269846 | Cosmetic Applicator - An apparatus for applying a cosmetic, such as mascara to eyelashes, includes a handle, a stem, and an applicator head coupled to the stem and supported for rotation relative to the handle. An actuator moves the applicator head in a rotational oscillating motion, in which the applicator head automatically rotates in both a first rotational direction and a second rotational direction in response to operation of the actuator. Additionally or alternatively, the actuator may also radially translate the applicator head, move the applicator head through an angle of rotation less than 360 degrees, and vary the rotational speed of the applicator head. The applicator head may include protrusions that are spaced to define gaps during rotation, thereby to promote coverage and separation of eyelashes. | 10-28-2010 |
Paul B. Mishkin, Burlingame, CA US
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20150314198 | ONLINE GAME CREATION USING DATA SETS - The disclosed embodiments provide a system that facilitates creation of an online game. During operation, the system obtains a data set and a game template for the online game. Next, the system enables a user to select one or more subsets of the data set for use with the game template. Finally, the system creates the online game from the game template and data from the one or more subsets without requiring manual input of the data into the game template by the user. | 11-05-2015 |