Patent application number | Description | Published |
20080220040 | Nitric Oxide Donating Medical Devices and Methods of Making Same - Disclosed are implantable medical devices comprising nitric oxide (NO) donating polymers comprising polymer backbones having at least one cyclic amine disposed thereon. Methods are further disclosed for providing nitric oxide-donating polymers. | 09-11-2008 |
20080220046 | Terpolymers for Controlled Release of Bioactive Agents From Implantable Medical Devices - Disclosed herein are implantable medical devices comprising controlled release terpolymers and at least one drug releasable from said terpolymers coating. The terpolymers of the present invention are comprised of acrylate and/or vinyl monomers. | 09-11-2008 |
20080233168 | Medical Devices And Coatings Therefore Comprising Biodegradable Polymers With Enhanced Functionality - Biodegradable polymers useful for fabricating implantable medical devices and as coatings for medical devices are provided. The biodegradable polymers are biocompatible and can be tuned to provide optimum bioactive agent elution rates as well as degradation rates. Also provided are methods for making medical devices and medical device coatings using the biodegradable polymers. | 09-25-2008 |
20080233169 | 4-Aza-Caprolactone-Based Polymeric Compositions Useful for the Manufacture of Biodegradable Medical Devices and as Medical Device Coatings - N-substituted 4-aza-caprolactone biodegradable polymers, including derivatives thereof, useful for making implantable medical devices and coatings therefore are provided. The medical devices and coatings of the present invention can also be used for in situ controlled release drug delivery and are useful for treating or preventing medical conditions such as restenosis, aneurisms and vulnerable plaque. | 09-25-2008 |
20080254085 | Degradable Polymers Incorporating Gamma-Butyrolactone - Disclosed herein are implantable medical devices having controlled release biodegradable polymer coatings thereon wherein the polymer is formed from ring opening of γ-butyrolactone and at least one additional monomer selected from the group consisting of trimethylene carbonate, lactide, polyethylene glycol, glycolide, the monomers formed from ring opening of ε-caprolactone, 4-tert-butyl caprolactone, and N-acetyl caprolactone, and combinations thereof, and at least one drug releasable from the biodegradable polymer. Also disclosed are implantable medical devices form of the biodegradable polymers and processes for forming the polymers. | 10-16-2008 |
20080305143 | Controlled Radical Polymerization-Derived Block Copolymer Compositions for Medical Device Coatings - Controlled radical polymerization-derived biocompatible block copolymer coatings for medical devices are disclosed. Specifically, block copolymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed. The present application also discloses providing vascular stents with drug-eluting controlled release block copolymer coatings and related methods for making these medical devices and coatings. | 12-11-2008 |
20090022769 | Medical Devices Comprising Polymeric Drug Delivery Systems With Drug Solubility Gradients - Disclosed are drug delivery systems comprising drugs admixed with polymers having drug solubility gradients and methods of making the polymers. Also disclosed are medical devices having coatings thereon comprising the drug solubility gradient-containing polymers and at least one drug. | 01-22-2009 |
20090028966 | Methods for Introducing Reactive Secondary Amines Pendant to Polymers Backbones that are Useful for Diazeniumdiolation - Biocompatible polymers having polymer backbones with at least one secondary amine suitable for diazeniumdiolation are disclosed. Specifically, methods for providing secondary amines-containing polymers using epoxide-opening reactions are provided. More specifically, nitric oxide-releasing medical devices made using these polymers are disclosed. | 01-29-2009 |
20090043378 | Biocompatible Polymer System for Extended Drug Release - A self-orienting biocompatible polymer system incorporating a hydrophilic surface and a hydrophobic core are disclosed. The hydrophilic surface aids in biocompatibility while the hydrophobic core allows the polymer system to accommodate a hydrophobic drug. Medical devices coated with the polymer system are also disclosed. | 02-12-2009 |
20090222088 | Secondary Amine Containing Nitric Oxide Releasing Polymer Composition - Disclosed herein are polymers used to coat or form implantable medical devices. The polymers comprise secondary amines useful in binding nitric oxide (NO). After diazeniumdiolation, the polymers can sustain controlled release of NO. In one embodiment, the secondary amines are linked to a functionalized dendrimer. In another embodiment, secondary amines are chelated with copper (II) which in turn serve as a catalyst for NO production. | 09-03-2009 |
20090232863 | Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers - Disclosed herein are implantable medical devices coated with or comprising bioabsorbable carbon-based nitric oxide-donating polymers that upon exposure to physiological environments donate nitric oxide (NO). | 09-17-2009 |
20090232868 | Nitric Oxide Releasing Polymer Composition - Disclosed herein are biocompatible carbon-based nitric oxide (NO) donating polymers suitable for forming and coating medical devices. These polymers have acrylate backbones and are comprised of substantially hydrophobic monomers. The NO donating polymers are carbon based wherein the diazeniumdiolate group is attached to the acetate group on an acetate based monomer. Incorporating a vinyl acetate monomer into an acrylate based polymer allows diazeniumdiolation of a polymer that would otherwise not accommodate the diazeniumdiolate group. | 09-17-2009 |
20100159119 | Dry Diazeniumdiolation Methods for Producing Nitric Oxide Releasing Medical Devices - The methods of the present disclosure in a broad aspect provide for dry diazeniumdiolation procedures for producing nitric oxide releasing medical devices. These medical devices may alternatively have cap coats applied prior to dry diazeniumdiolation to produce nitric oxide releasing medical devices with cap coats. | 06-24-2010 |
20100198338 | Hydrogen Sulfide Donating Polymers - Described herein are hydrogen sulfide (H | 08-05-2010 |
20100247597 | Biocompatible Polymers for Coating or Fabricating Implantable Medical Devices - The present disclosure generally relates to biocompatible polymers for coating or fabricating implantable medical devices and to implantable medical devices having the present biocompatible polymers. The disclosed biocompatible polymers exhibit superior biocompatibility and therefore minimize unwanted immune reaction from a patient into whom a medical device is implanted. | 09-30-2010 |
20100262238 | Diazeniumdiolated Phosphorylcholine Polymers for Nitric Oxide Release - The present disclosure in a broad aspect provides for diazeniumdiolated phosphorylcholine polymers and associated methods for achieving nitric oxide release. The present polymers have superior biocompatibility and are useful for coating or fabricating medical devices such as a vascular stent. | 10-14-2010 |
20110104234 | Biodegradable Modified Carpolactone Polymers for Fabrication and Coating Medical Devices - Disclosed herein are biodegradable modified caprolactone polymers for coating and forming medical devices. The properties of the polymers are fine tuned for optimal performance depending on the medical purpose. Moreover, the polymers are suitable for the controlled in situ release of drugs at the treatment site. | 05-05-2011 |
20110150966 | DEGRADABLE POLYMERS INCORPORATING GAMMA-BUTYROLACTONE - Disclosed herein are implantable medical devices having controlled release biodegradable polymer coatings thereon wherein the polymer is formed from ring opening of γ-butyrolactone and at least one additional monomer selected from the group consisting of trimethylene carbonate, lactide, polyethylene glycol, glycolide, the monomers formed from ring opening of ε-caprolactone, 4-tert-butyl caprolactone, and N-acetyl caprolactone, and combinations thereof, and at least one drug releasable from the biodegradable polymer. Also disclosed are implantable medical devices form of the biodegradable polymers and processes for forming the polymers. | 06-23-2011 |
20110165216 | Hydrogen Sulfide Generating Polymers - Described herein are hydrogen sulfide (H | 07-07-2011 |
20110301299 | Medical Devices and Polymers Therefor Having PTFE Surfaces Modified With Nitric Oxide-Releasing Polymers - Described herein are polymers useful for forming or coating implantable medical devices and such medical devices. The polymers are biocompatible and hemocompatible and comprise PTFE surfaces modified by covalently linking a nitric oxide releasing polymer to the PTFE surface through a linking group. Further described are precursor polymers and processes for preparing such polymers and precursor polymers. | 12-08-2011 |
20120239131 | METHODS AND APPARATUS FOR TREATMENT OF ANEURYSMAL TISSUE - Methods and apparatus for aiding aneurysm repair are provided. Such apparatus is constructed to support or bolster the aneurysmal site and supply a therapeutic agent to aid in healing the surrounding aneurysmal tissue. | 09-20-2012 |
20120269897 | POLY(TETRAFLUOROETHYLENE) POLYMER WITH NITRIC OXIDE DONATING SURFACE - Described herein are nitric oxide (NO)-donating poly(tetrafluoroethylene) (PTFE) polymers and polymer surfaces and methods of making and using the same. The NO-donating PTFE polymers can be used to fabricate at least a portion of an implantable medical device, coat at least a portion of an implantable medical device or form at least a portion of an implantable medical device. The NO-donating PTFE polymers provide controlled release of NO once implanted at or within the target site. | 10-25-2012 |
20130345314 | Compositions and methods for treating a damaged cardiovascular element - In the present invention, the applicants describe methods and compositions of treating damaged cardiovascular elements and cardiovascular conditions including hypotension, atherosclerotic lesions, vulnerable plaque, and acute myocardial infarct. The applicants demonstrate the ability of a biomembrane sealing agent to accumulate on the walls of damaged blood vessels and help improving mean arterial pressure following tissue injury. The applicants describe the use of formulations comprising at least one biomembrane sealing agent and one bioactive agent for prophylactic treatment such as they could be administered concurrently to an invasive therapeutic intervention or after the insult (i.e. post-injury or post-surgery). Alternatively, these methods and compositions could be used to reduce the severity of cardiovascular diseases after onset. | 12-26-2013 |
20140276791 | Treatment Device With Electrode Contact Surface Configured for Enhancing Uniformity of Electrical Energy Distribution and Associated Devices and Methods - Treatment devices with electrode contact surfaces configured for enhancing uniformity of electrical energy distribution are provided. In one embodiment, a treatment device includes a tubular electrode having a wall, a contact surface defined by the wall, and cut shapes at least partially extending through the wall. The tubular electrode is configured to transmit electrical energy to a treatment site within a body lumen via the contact surface, and the individual cut shapes are configured to draw a portion of the electrical energy toward an interior region of the contact surface. A shaft having a distal end portion operably coupled to the tubular electrode can locate the tubular electrode at the treatment site. | 09-18-2014 |
20140277337 | Medical Device and Plasticized Nylon - A medical device, such as a dilatation balloon, including plasticized nylon, and plasticized nylon. | 09-18-2014 |
20140370071 | Medical Devices Comprising Polymeric Drug Delivery Systems With Drug Solubility Gradients - Disclosed are drug delivery systems comprising drugs admixed with polymers having drug solubility gradients and methods of making the polymers. Also disclosed are medical devices having coatings thereon comprising the drug solubility gradient-containing polymers and at least one drug. | 12-18-2014 |